FlyBase Gene Report: Dmel\Gαo

General Information

Symbol

Dmel\Gαo

Species

D. melanogaster

Name

G protein α o subunit

Annotation Symbol

CG2204

Feature Type

protein_coding_gene

FlyBase ID

FBgn0001122

Gene Model Status

Stock Availability

25 publicly available

Gene Snapshot

G protein α o subunit (Gαo) encodes the most abundant G protein in the nervous tissue and is involved in signaling by a variety of GPCRs. It contributes to heart development, axonogenesis, neuro-muscular junction formation, asymmetric cell division, planar cell polarity, blood-brain barrier establishment, Wnt signaling, and gustatory and olfactory sensory perception. [Date last reviewed: 2019-03-07]

Other Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Red Book
Interactive Fly

Also Known As

G-oα47A, G-oalpha47A, Go, Goα, Gα_o

Key Links

Genomic Location

Cytogenetic map

Sequence location

2R:10,437,985..10,465,701 [+]

Recombination map

2-62

RefSeq locus

NT_033778 REGION:10437985..10465701

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (23 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables GTP binding

inferred from direct assay

(Cooper et al., 2011)

enables protein binding

inferred from physical interaction with FLYBASE:Dhit; FB:FBgn0028743

(Lin et al., 2014)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables G protein-coupled receptor binding

inferred from biological aspect of ancestor with PANTHER:PTN000026392

(assigned by GO_Central )

(Gaudet et al., 2011)

enables G-protein beta/gamma-subunit complex binding

inferred from biological aspect of ancestor with PANTHER:PTN000026392

(assigned by GO_Central )

(Gaudet et al., 2011)

enables GTPase activity

inferred from biological aspect of ancestor with PANTHER:PTN000026392

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (16 terms)

Terms Based on Experimental Evidence (14 terms)

CV Term

Evidence

References

involved_in asymmetric cell division

inferred from mutant phenotype

(Katanaev and Tomlinson, 2006)

involved_in axon ensheathment in central nervous system

inferred from mutant phenotype

(assigned by UniProt )

(Schwabe et al., 2005)

involved_in behavioral response to starvation

inferred from mutant phenotype

(Koon and Budnik, 2012)

involved_in calcium-mediated signaling

inferred from mutant phenotype

(Ignatious Raja et al., 2014)

involved_in cell adhesion involved in heart morphogenesis

inferred from mutant phenotype

(Yi et al., 2008)

involved_in cortical actin cytoskeleton organization

inferred from mutant phenotype

(Schwabe et al., 2005)

involved_in establishment of glial blood-brain barrier

inferred from mutant phenotype

(Schwabe et al., 2005)

involved_in establishment of imaginal disc-derived wing hair orientation

inferred from mutant phenotype

(Katanaev et al., 2005)

involved_in G protein-coupled receptor signaling pathway

inferred from mutant phenotype

(assigned by UniProt )

(Schwabe et al., 2005)

involved_in negative regulation of synaptic growth at neuromuscular junction

inferred from mutant phenotype

(Koon and Budnik, 2012)

involved_in non-canonical Wnt signaling pathway

inferred from mutant phenotype

(Katanaev et al., 2005)

involved_in sensory perception of sweet taste

inferred from mutant phenotype

(Bredendiek et al., 2011)

involved_in septate junction assembly

inferred from mutant phenotype

(Schwabe et al., 2005)

involved_in ventral cord development

inferred from mutant phenotype

(Schwabe et al., 2005)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN000026392

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in heart development

traceable author statement

(Cripps and Olson, 2002)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

part_of heterotrimeric G-protein complex

inferred from direct assay

(Katanayeva et al., 2010)

located_in plasma membrane

inferred from high throughput direct assay

(Tan et al., 2009)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

part_of heterotrimeric G-protein complex

inferred from biological aspect of ancestor with PANTHER:PTN000026392

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

HETEROTRIMERIC G-PROTEIN ALPHA SUBUNITS

Protein Family (UniProt)

Belongs to the G-alpha family. G(i/o/t/z) subfamily. (P16378)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

HETEROTRIMERIC G-PROTEIN ALPHA SUBUNITS -: The Heterotrimeric G-protein alpha subunits (Gα) can bind guanine nucleotide. When inactive, Gα is bound to GDP and associates with Gβγ forming an heterotrimer. Upon GTP binding, Gα dissociates from the heterotrimer Gαβγ. Gα has an intrinsic guanosine triphosphatase (GTPase) activity. (Adapted from FBrf0209904 and FBrf0183798).

Protein Function (UniProtKB)

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Plays a role in glial cell differentiation during embryogenesis; loco, Galphai and the G-protein coupled receptor, moody, are required in the surface glia to achieve effective insulation of the nerve cord.

(UniProt, P16378)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

Gα47A: G protein α subunit at 47A

Encodes a G protein α subunit that is expressed mainly in the nervous system (DeSousa et al., 1989; Thambi et al., 1989) and shows homology to mammalian Goα. Low levels of this G protein are found in the embryo until completion of germband shortening; then high levels begin to be expressed in the neuropil (Wolfgang, et al., 1990).

Summary (Interactive Fly)

G protein alpha subunit - regulates mesenchymal-epithelial transition that takes place in cardial cells and precursor cells of the visceral musculature

Interactive Fly

Gene Model and Products

Number of Transcripts

10

Number of Unique Polypeptides

3

Please see the JBrowse view of Dmel\Gαo for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated

Sequence Ontology: Class of Gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0088266

3462

354

FBtr0088264

2312

354

FBtr0088265

2367

354

FBtr0088267

2239

354

FBtr0088268

2294

354

FBtr0088269

2212

354

FBtr0088270

2322

354

FBtr0088271

2194

354

FBtr0088272

5457

354

FBtr0333064

1785

127

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

FBpp0087361

40.5

354

5.20

FBpp0087359

40.5

354

5.20

FBpp0087360

40.5

354

5.20

FBpp0087362

40.5

354

5.20

FBpp0087363

40.5

354

5.20

FBpp0087364

40.5

354

5.20

FBpp0087365

40.5

354

5.20

FBpp0089315

40.5

354

5.20

FBpp0089316

40.5

354

5.20

FBpp0305278

14.6

127

4.48

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

354 aa isoforms: Gαo-PB, Gαo-PD, Gαo-PE, Gαo-PF, Gαo-PG, Gαo-PH

354 aa isoforms: Gαo-PA, Gαo-PC, Gαo-PI

Additional Polypeptide Data and Comments

Reported size (kDa)

39-40 (kD)

(Guillen et al., 1990)

Comments

External Data

Subunit Structure (UniProtKB)

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

(UniProt, P16378)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gαo using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

distribution deduced from reporter

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 13

embryonic dorsal vessel

(Zaffran et al., 2001)

ventral nerve cord

(Zaffran et al., 2001)

visceral mesoderm of midgut

(Zaffran et al., 2001)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 11

cardiogenic mesoderm | segmentally repeated

Comment: one cell cluster per segment

(Fremion et al., 1999)

embryonic stage 11 -- 13

embryonic cardioblast

(Fremion et al., 1999)

embryonic stage 13 -- 14

dorsal vessel primordium

(Fremion et al., 1999)

embryonic stage 15 -- 17

embryonic dorsal vessel

(Fremion et al., 1999)

neuron of embryonic/larval central nervous system

(Fremion et al., 1999)

embryonic stage 11 -- 12

visceral muscle primordium

(Fisher et al., 2012, Fremion et al., 1999)

dorsal vessel primordium

Comment: reported as dorsal vessel specific anlage

(Fisher et al., 2012)

embryonic stage 13 -- 17

embryonic visceral muscle

(Fremion et al., 1999)

neuron of embryonic/larval peripheral nervous system

(Fremion et al., 1999)

embryonic stage 11 -- 15

procephalic neuroblast

(Fremion et al., 1999)

neuroblast of ventral nervous system

(Fremion et al., 1999)

embryonic stage 12 -- 15

neuroblast of embryonic/larval central nervous system

(Fremion et al., 1999)

embryonic stage 1 -- 3

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic/larval dorsal vessel

(Fisher et al., 2012)

embryonic/larval visceral muscle

(Fisher et al., 2012)

ventral nerve cord

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 4

Comment: reference states 0-2 hr AEL

(Wolfgang et al., 1991)

embryonic stage -- pupal stage

(Wolfgang et al., 1991)

radioisotope in situ

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage & oogenesis

(Wolfgang et al., 1991)

(Wolfgang et al., 1991)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

(Boto et al., 2010)

third segment of antenna

(Boto et al., 2010)

maxillary palpus

Comment: all isoforms except Go-RA, Go-RC and Go-RI (G-oα47A-RA, G-oα47A-RC and G-oα47A-RI)

(Boto et al., 2010)

(Yao and Carlson, 2010)

(Bredendiek et al., 2011)

adult stage | male

(McGurk et al., 2008)

Additional Descriptive Data

RT-PCR analysis shows that all isoforms of G-oα47A except G-oα47A-RA, G-oα47A-RC and G-oα47A-RI are expressed in the adult head, third segment of the antenna and maxillary palps. The latter 3 isoforms are only detected in the adult head and third segment of the antenna.

(Boto et al., 2010)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

lamina | restricted

(Wolfgang et al., 1990)

adult antennal nerve | restricted

(Wolfgang et al., 1990)

adult brain cell body rind

(Wolfgang et al., 1990)

ocellar nerve | proximal

(Wolfgang et al., 1990)

embryonic stage 15 -- 17

embryonic/larval digestive system

(Fremion et al., 1999)

embryonic/larval central nervous system

(Fremion et al., 1999)

embryonic/larval dorsal vessel

(Fremion et al., 1999)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 7 of adulthood -- day 49 of adulthood

(Cammarato et al., 2011)

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Up to stage 13 of embryogenesis, G-oα47A protein is detected only at low levels. After germ band retraction, and through the rest of embryogenesis, G-oα47A protein is detected in the neuropil of the brain and ventral ganglion.

(Wolfgang et al., 1991)

G-oα47A protein is more abundant in heads than bodies. No changes in protein levels were seen in para, sev, ora and norpA mutants. G-oα47A protein levels are decreased in gust mutants and increased in rut, dnc and tur mutants and the over-expression is sex-dependent in the rut mutant.

(Guillen et al., 1990)

G-oα47A protein is detected in the neuropil of the brain and the thoracic ganglion, and at lower levels in cortical regions. Some staining was detected in the distal lamina and in the synaptic zone of the lamina. The proximal half of the ocellar nerve, and a bundle of axons in the antennal nerve also stained for G-oα47A protein.

(Wolfgang et al., 1990)

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of heterotrimeric G-protein complex

inferred from direct assay

(Katanayeva et al., 2010)

located_in plasma membrane

inferred from high throughput direct assay

(Tan et al., 2009)

Expression Deduced from Reporters

Reporter: P{lacW}Gαo^k06915

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 15 -- 17

embryonic/larval gut

(Fremion et al., 1999)

Reporter: P{lacW}Gαo^k07810

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 15 -- 17

embryonic/larval digestive system

(Fremion et al., 1999)

embryonic/larval central nervous system

(Fremion et al., 1999)

embryonic/larval dorsal vessel

(Fremion et al., 1999)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Gαo in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Gαo

View exonic expression by tissue for Dmel\Gαo

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0001122

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0001122

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG2204-RB

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG2204

Flygut - An atlas of the Drosophila adult midgut

FBgn0001122

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Gαo

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 11-12
Stages(s) 13-16

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 44 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 22 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Gαo

Transgenic constructs containing regulatory region of Gαo

Deletions and Duplications ( 6 )

Disrupted in

(Guillen et al., 1995)

(Katanaev et al., 2005, Fremion et al., 1999)

Not disrupted in

(BDGP Project Members, 1994-1999)

(BDGP Project Members, 1994-1999)

(BDGP Project Members, 1994-1999)

(BDGP Project Members, 1994-1999)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Gαo^GD8640

lethal (with Df(2R)47A)

Gαo⁰⁶¹¹

lethal | recessive

lethal - all die during embryonic stage, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Gαo^GD8640

partially lethal - majority die

Gαo^CA06658

viable, with Scer\GAL4^Mef2.PR

Gαo^GD8640

viable, with Scer\GAL4^pnr-MD237

Gαo^GD8640

viable, with Scer\GAL4^tin.CΔ4

Gαo^GD8640

Other Phenotypes

Allele

cell polarity defective, with Scer\GAL4^Bx-MS1096

Gαo^UAS.cKa

cell polarity defective, with Scer\GAL4^pnr-MD237

Gαo^GTP.UAS

cell polarity defective | somatic clone

Gαo⁰⁰⁷

circadian rhythm defective, with Scer\GAL4^P0.5.Pdf

heat stress response defective | third instar larval stage, with Scer\GAL4^ppk.1.9

Gαo^JF02844

memory defective | adult stage, with Scer\GAL4^GH146

Gαo^GD8640

memory defective | adult stage, with Scer\GAL4^NP2631

Gαo^GD8640

mitotic cell cycle defective, with Scer\GAL4^Bx-MS1096

Gαo^UAS.cKa

neuroanatomy defective, with Scer\GAL4^repo

neuroanatomy defective | third instar larval stage, with Scer\GAL4^BG439

neuroanatomy defective | third instar larval stage, with Scer\GAL4^futsch-C380

neuroanatomy defective | third instar larval stage, with Scer\GAL4^ppk.1.9

Gαo^JF02844

neuroanatomy defective | third instar larval stage, with Scer\GAL4^Tdc2.PC

neurophysiology defective

Gαo^EP2154

neurophysiology defective, with Scer\GAL4^Gr5a.PUn

Gαo^VDRC.cUa

neurophysiology defective | dominant

Gαo^NP3200

neurophysiology defective | heat sensitive, with Scer\GAL4^hs.PB

Gαo^VDRC.cUa

planar polarity defective, with Scer\GAL4^Bx-MS1096

Gαo^UAS.cKa

planar polarity defective, with Scer\GAL4^pnr-MD237

Gαo^GTP.UAS

planar polarity defective | cell autonomous, with Scer\GAL4^Bx-MS1096

Gαo^GTP.UAS

planar polarity defective | cell non-autonomous | recessive | somatic clone

Gαo⁰⁰⁷

planar polarity defective | recessive | somatic clone

planar polarity defective | somatic clone

Gαo⁰⁰⁷

starvation stress response defective | third instar larval stage, with Scer\GAL4^Tdc2.PC

Gαo^KK109018

taste perception defective

Gαo^EP2154

taste perception defective, with Scer\GAL4^Gr5a.PUn

Gαo^VDRC.cUa

taste perception defective | dominant

Gαo^NP3200

taste perception defective | heat sensitive, with Scer\GAL4^hs.PB

Gαo^VDRC.cUa

visible, with Scer\GAL4^Bx-MS1096

Gαo^GD8640

visible | somatic clone

Gαo⁰⁰⁷

Phenotype manifest in

Allele

dendrite | third instar larval stage, with Scer\GAL4^ppk.1.9

Gαo^JF02844

embryonic/first instar larval cuticle

embryonic/larval dorsal vessel

embryonic/larval neuromuscular junction | third instar larval stage, with Scer\GAL4^Tdc2.PC

embryonic/larval visceral muscle

Gαo⁰⁰⁷

embryonic pericardial cell

Gαo^unspecified

eo glial cell, with Scer\GAL4^sca-537.4

Gαo^GTP.UAS

eo glial cell | ectopic, with Scer\GAL4^sca-537.4

Gαo^GTP.UAS

eo neuron, with Scer\GAL4^pnr-MD237

Gαo^GTP.UAS

eo neuron | ectopic, with Scer\GAL4^pnr-MD237

Gαo^GTP.UAS

eo neuron | ectopic | somatic clone

Gαo⁰⁰⁷

eo neuron | somatic clone

Gαo⁰⁰⁷

eo sensory structure, with Scer\GAL4^pnr-MD237

Gαo^GTP.UAS

eo sensory structure, with Scer\GAL4^sca-537.4

Gαo^GTP.UAS

eo sensory structure | ectopic, with Scer\GAL4^pnr-MD237

Gαo^GTP.UAS

eo sensory structure | ectopic | somatic clone

Gαo⁰⁰⁷

eo sensory structure | somatic clone

Gαo⁰⁰⁷

heart primordium | embryonic stage

Gαo^unspecified

large labellar taste bristle

large labellar taste bristle, with Scer\GAL4^Gr5a.PUn

Gαo^VDRC.cUa

large labellar taste bristle | heat sensitive, with Scer\GAL4^hs.PB

Gαo^VDRC.cUa

larval dorsal multidendritic neuron ddaC | third instar larval stage, with Scer\GAL4^ppk.1.9

Gαo^JF02844

longitudinal connective

Gαo⁰⁰⁷

macrochaeta, with Scer\GAL4^pnr-MD237

Gαo^GTP.UAS

macrochaeta | somatic clone

Gαo⁰⁰⁷

mechanosensory sensory organ, with Scer\GAL4^pnr-MD237

Gαo^GTP.UAS

medial triple row, with Scer\GAL4^pnr-MD237

Gαo^GTP.UAS

medial triple row & eo neuron, with Scer\GAL4^pnr-MD237

Gαo^UAS.cKa

medial triple row & eo sensory structure, with Scer\GAL4^pnr-MD237

Gαo^UAS.cKa

medial triple row & sensory organ cell, with Scer\GAL4^pnr-MD237

Gαo^UAS.cKa

medial triple row & socket, with Scer\GAL4^pnr-MD237

Gαo^UAS.cKa

motor neuron | embryonic stage

Gαo⁰⁰⁷

Gαo^B97

neuroblast, with Scer\GAL4^{VP16.mat.αTub67C}

Gαo^Q205L.UAS

neuroblast & spindle, with Scer\GAL4^{VP16.mat.αTub67C}

Gαo^II.UAS

pupa, with Scer\GAL4^CCAP.PP

Gαo^UAS.cKa

scolopidial neuron, with Scer\GAL4^sca-537.4

Gαo^GTP.UAS

scolopidial neuron | ectopic, with Scer\GAL4^sca-537.4

Gαo^GTP.UAS

sensory mother cell, with Scer\GAL4^sca-537.4

Gαo^GTP.UAS

sensory organ cell, with Scer\GAL4^pnr-MD237

Gαo^GTP.UAS

sensory organ cell | ectopic, with Scer\GAL4^pnr-MD237

Gαo^GTP.UAS

sensory organ cell | ectopic | somatic clone

Gαo⁰⁰⁷

sensory organ cell | somatic clone

Gαo⁰⁰⁷

thecogen cell, with Scer\GAL4^sca-537.4

Gαo^GTP.UAS

thecogen cell | ectopic, with Scer\GAL4^sca-537.4

Gαo^GTP.UAS

tormogen cell, with Scer\GAL4^pnr-MD237

Gαo^GTP.UAS

tormogen cell, with Scer\GAL4^sca-537.4

Gαo^GTP.UAS

tormogen cell | ectopic, with Scer\GAL4^pnr-MD237

Gαo^GTP.UAS

tormogen cell | ectopic, with Scer\GAL4^sca-537.4

Gαo^GTP.UAS

tormogen cell | ectopic | somatic clone

Gαo⁰⁰⁷

tormogen cell | somatic clone

Gαo⁰⁰⁷

type I bouton | supernumerary | third instar larval stage, with Scer\GAL4^BG439

type I bouton | supernumerary | third instar larval stage, with Scer\GAL4^futsch-C380

type II bouton | supernumerary | third instar larval stage, with Scer\GAL4^futsch-C380

Gαo^KK109018

type II bouton | supernumerary | third instar larval stage, with Scer\GAL4^Tdc2.PC

wing, with Scer\GAL4^Bx-MS1096

Gαo^GD8640

wing | somatic clone

wing hair | cell autonomous | supernumerary, with Scer\GAL4^Bx-MS1096

Gαo^GTP.UAS

wing hair | somatic clone | supernumerary

wing hair | supernumerary, with Scer\GAL4^Bx-MS1096

wing margin | somatic clone

Gαo⁰⁰⁷

wing margin bristle, with Scer\GAL4^Bx-MS1096

wing margin bristle, with Scer\GAL4^pnr-MD237

Gαo^GTP.UAS

wing margin bristle | cell non-autonomous | somatic clone

Gαo⁰⁰⁷

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (16)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

14 of 15

Yes

Yes

4

4 of 15

No

No

4 of 15

No

No

3 of 15

No

No

3 of 15

No

No

3 of 15

No

No

3 of 15

No

No

2 of 15

No

No

1

2 of 15

No

No

2 of 15

No

No

1

2 of 15

No

No

2 of 15

No

No

2 of 15

No

No

2 of 15

No

No

1 of 15

No

No

1 of 15

No

No

2

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (16)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

13 of 15

Yes

Yes

4 of 15

No

No

4 of 15

No

No

3 of 15

No

No

3 of 15

No

No

3 of 15

No

No

3 of 15

No

No

2 of 15

No

No

2 of 15

No

No

2 of 15

No

No

2 of 15

No

No

2 of 15

No

No

2 of 15

No

No

2 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Rattus norvegicus (Norway rat) (14)

12 of 13

Yes

Yes

3 of 13

No

No

3 of 13

No

No

3 of 13

No

No

3 of 13

No

No

3 of 13

No

No

2 of 13

No

No

2 of 13

No

No

2 of 13

No

No

2 of 13

No

No

2 of 13

No

No

2 of 13

No

No

2 of 13

No

No

1 of 13

No

No

Xenopus tropicalis (Western clawed frog) (14)

8 of 12

Yes

Yes

2 of 12

No

No

2 of 12

No

No

2 of 12

No

No

2 of 12

No

No

2 of 12

No

No

2 of 12

No

No

2 of 12

No

No

2 of 12

No

No

2 of 12

No

No

2 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

Danio rerio (Zebrafish) (27)

11 of 15

Yes

Yes

11 of 15

Yes

Yes

4 of 15

No

No

3 of 15

No

No

3 of 15

No

No

3 of 15

No

No

3 of 15

No

No

3 of 15

No

No

3 of 15

No

No

3 of 15

No

No

2 of 15

No

No

2 of 15

No

No

2 of 15

No

No

2 of 15

No

No

2 of 15

No

No

2 of 15

No

No

2 of 15

No

No

2 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Caenorhabditis elegans (Nematode, roundworm) (20)

13 of 15

Yes

Yes

6 of 15

No

Yes

5 of 15

No

Yes

5 of 15

No

No

4 of 15

No

No

4 of 15

No

Yes

4 of 15

No

Yes

4 of 15

No

No

4 of 15

No

Yes

4 of 15

No

Yes

4 of 15

No

Yes

4 of 15

No

Yes

2 of 15

No

No

2 of 15

No

No

2 of 15

No

No

2 of 15

No

No

2 of 15

No

No

2 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Arabidopsis thaliana (thale-cress) (4)

Atha\GP ALPHA 1

7 of 9

Yes

No

2 of 9

No

No

2 of 9

No

No

2 of 9

No

No

Saccharomyces cerevisiae (Brewer's yeast) (2)

9 of 15

Yes

Yes

8 of 15

No

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

10 of 12

Yes

Yes

6 of 12

No

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190A4T )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Drosophila persimilis

Drosophila willistoni

Drosophila virilis

Drosophila mojavensis

Drosophila grimshawi

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150A85 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Glossina morsitans

Tsetse fly

Gmor\GMOY009170

Mayetiola destructor

Hessian fly

Mdes\Mdes006286

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL008641

Anopheles darlingi

American malaria mosquito

Adar\ADAC010290

Anopheles gambiae

Malaria mosquito

Agam\AGAP005773

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ000066

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0CGF )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA004022

Danaus plexippus

Monarch butterfly

Dple\DPOGS211768-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL007940

Apis florea

Little honeybee

Aflo\2781951188

Apis florea

Little honeybee

Aflo\3155208596

Apis mellifera

Western honey bee

Apis mellifera

Western honey bee

Bombus impatiens

Common eastern bumble bee

Bombus impatiens

Common eastern bumble bee

Bombus terrestris

Buff-tailed bumblebee

Bombus terrestris

Buff-tailed bumblebee

Linepithema humile

Argentine ant

Linepithema humile

Argentine ant

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0029c8

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000c30

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG037232

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG019514

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG017607

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG031438

Dendroctonus ponderosae

Mountain pine beetle

Dendroctonus ponderosae

Mountain pine beetle

Tribolium castaneum

Red flour beetle

Tribolium castaneum

Red flour beetle

Pediculus humanus

Human body louse

Phum\PHUM378990

Pediculus humanus

Human body louse

Phum\PHUM527150

Rhodnius prolixus

Kissing bug

Rpro\RPRC005906

Rhodnius prolixus

Kissing bug

Rpro\RPRC011274

Cimex lectularius

Bed bug

Clec\CLEC002916

Cimex lectularius

Bed bug

Clec\CLEC007940

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI005077

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI009431

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_03729

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_11464

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0CE7 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR013384

Strigamia maritima

European centipede

Smar\SMAR010110

Ixodes scapularis

Black-legged tick

Isca\ISCW008109

Ixodes scapularis

Black-legged tick

Isca\ISCW017464

Stegodyphus mimosarum

African social velvet spider

Smim\KFM75456.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM59373.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM79146.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM61420.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur05g01580

Tetranychus urticae

Two-spotted spider mite

Turt\tetur04g03270

Tetranychus urticae

Two-spotted spider mite

Turt\tetur15g03060

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_37840

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_211929

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_59367

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_188187

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_193276

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0VUT )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Gol/Dup

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Gicterm

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000003915

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000000283

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000000839

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000005305

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000018963

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000028697

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000004639

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000028452

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000000041

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000003238

Gallus gallus

Domestic chicken

Gallus gallus

Domestic chicken

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (7)

Gene Symbol

Score

Source

Alignment

7 of 10

5 of 10

5 of 10

5 of 10

4 of 10

4 of 10

3 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

neurological disorders, GNAO1-related

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

GNAO1; G protein subunit alpha o1

model of early infantile epileptic encephalopathy 17

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

DOES NOT ameliorate Alzheimer's disease

modeled by Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}

(Lüchtenborg and Katanaev, 2014)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

GNAO1; G protein subunit alpha o1

14 of 15

early infantile epileptic encephalopathy 17

GNAI1; G protein subunit alpha i1

4 of 15

GNAI2; G protein subunit alpha i2

4 of 15

VENTRICULAR TACHYCARDIA, FAMILIAL

GNAI3; G protein subunit alpha i3

3 of 15

AURICULOCONDYLAR SYNDROME 1; ARCND1

GNAT2; G protein subunit alpha transducin 2

3 of 15

ACHROMATOPSIA 4; ACHM4

achromatopsia 4

GNAT3; G protein subunit alpha transducin 3

3 of 15

GNAZ; G protein subunit alpha z

3 of 15

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

pull down, western blot, two hybrid

(Lüchtenborg et al., 2014)

pull down, molecular weight estimation by staining

(Egger-Adam and Katanaev, 2010)

two hybrid, molecular sieving, molecular weight estimation by staining, pull down, western blot, enzymatic study, anti tag western blot

(Lin et al., 2014, Tishchenko et al., 2013)

pull down, peptide massfingerprinting

(Katanayeva et al., 2010)

pull down, peptide massfingerprinting

(Katanayeva et al., 2010)

pull down, anti tag western blot

(Purvanov et al., 2010)

pull down, anti tag western blot, western blot

(Purvanov et al., 2010)

(Kopein and Katanaev, 2009)

anti tag coimmunoprecipitation, western blot

(Yoshiura et al., 2012)

anti tag coimmunoprecipitation, peptide massfingerprinting, pull down, autoradiography

(Schaefer et al., 2000)

pull down, anti tag western blot, western blot

(Lin and Katanaev, 2013)

pull down, anti tag western blot, two hybrid, enzymatic study

(Lin et al., 2014, Kopein and Katanaev, 2009)

anti tag coimmunoprecipitation, anti tag western blot

(Patel et al., 2016)

anti tag coimmunoprecipitation, western blot, fluorescent resonance energy transfer, experimental knowledge based, pull down, anti bait coimmunoprecipitation, two hybrid, autoradiography

(Lüchtenborg et al., 2015, Yoshiura et al., 2012, Guruharsha et al., 2011, Kopein and Katanaev, 2009, Katanaev and Tomlinson, 2006, Schaefer et al., 2000)

Gαo - βTub56D

pull down, peptide massfingerprinting

(Katanayeva et al., 2010)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Lin et al., 2014)

enhanceable

(Katanaev and Tomlinson, 2006)

enhanceable

(Katanaev et al., 2005)

suppressible

(Katanaev and Tomlinson, 2006, Katanaev et al., 2005)

suppressible

(Katanaev and Tomlinson, 2006)

suppressible

(Lin and Katanaev, 2013)

enhanceable

(Katanaev and Tomlinson, 2006)

suppressible

(Dahdal et al., 2010)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Katanaev and Tomlinson, 2006)

enhanceable

(Katanaev et al., 2005)

enhanceable

(Lin and Katanaev, 2013)

enhanceable

(Katanaev and Tomlinson, 2006)

External Data

Subunit Structure (UniProtKB)

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

(UniProt, P16378 )

Linkouts

BioGRID - A database of protein and genetic interactions.

61922

DroID - A comprehensive database of gene and protein interactions.

FBgn0001122

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

36104

MIST (genetic) - An integrated Molecular Interaction Database

Galphao

MIST (protein-protein) - An integrated Molecular Interaction Database

Galphao

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

2R

Recombination map

2-62

Cytogenetic map

Sequence location

2R:10,437,985..10,465,701 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

47A7-47A9

Limits computationally determined from genome sequence between P{lacW}Hr46^k10308 and P{PZ}lola⁰⁰³⁴⁹&P{EP}lola^EP952

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

47A-47A

(determined by in situ hybridisation)

(de Sousa et al., 1989, Schmidt et al., 1989, Yoon et al., 1989)

Experimentally Determined Recombination Data

Location

2-62

(FlyBase, 2016)

2-61.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (25)

81099

w¹¹¹⁸; Gαo^G45E/CyO

81097

w¹¹¹⁸; Gαo^A221D/CyO

81098

w¹¹¹⁸; TI{TI}Gαo^KO/CyO

28010

y¹ v¹; P{TRiP.JF02844}attP2

33090

y¹ w^*; Mi{MIC}Gαo^MI00833

22924

y¹ w^67c23; Mi{ET1}Gαo^MB00893

13714

y¹ w^67c23; P{SUPor-P}Gαo^KG01266

113107

w^*; P{GawB}Gαo^NP3108

123567

w¹¹¹⁸; P{RS3}Gαo^CB-5328-3

104410

y^* w^*; P{GawB}Gαo^NP3200 / SM1

v110552

P{KK109018}VIE-260B

v19124

w¹¹¹⁸; P{GD8640}v19124

More stocks available...

Genomic Clones (28)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (108)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0001122

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0001122

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

36104

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Lüchtenborg et al., 2014, Schaefer et al., 2001, Wolfgang et al., 1990)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: G-oα47A CG2204

(Shue, 1999.11)

Source for identity of: Gαo G-oα47A

(FlyBase, 2009-)

Source for database merge of

Additional comments

FlyBase curator comment: Genes encoding Gα subunits that have been named for their molecular function/orthology have had their symbols and names standardized following the format used in FBrf0220456, which also reflects popular usage in the Drosophila literature.

(FlyBase, 2009-)

Other Comments

G-oα47A is required for the transduction of both the Wnt and planar polarity pathways.

(Katanaev et al., 2005)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

dsRNA made from templates generated with primers against this gene tested in a cl-8 cell reporter assay to examine any role of G-oα47A in the hh signalling pathway.

(Lum, 2003)

Area matching Drosophila GO protein alpha subunit homolog class II gene, Acc. No. M29602.

(Davies, 2001.3.15)

G-oα47A function is required for the formation of the heart, visceral musculature and the nervous system.

(Fremion et al., 1999)

Mutants show defects in the heart, visceral musculature and nervous system.

(Fremion et al., 1999)

Mutation rate at microsatellite loci in 119 lines maintained for approximately 250 generations is estimated to be 6.3x10^-6, at least one order of magnitude lower than the mutation rate in mammals.

(Schlotterer et al., 1998)

Mutant analysis demonstrates G-oα47A is required for embryonic development.

(Guillen et al., 1995)

G proteins belong to a family of membrane-associated guanine nucleotide-binding proteins that couple specific receptors for extracellular signals to specific intracellular effectors, thus regulating the activity of these effectors. When not interacting with the receptor, G proteins are usually in the form of a heterotrimer made up of α, β and γ subunits, with the α subunit bound to GDP. Upon activation by the receptor, the α subunit exchanges GDP for GTP, dissociates from the β-γ subunits and interacts with the effector. Afterwards GTP is hydrolyzed and the heterotrimer of α, β and γ subunits is formed again.

(Lindsley and Zimm, 1992)

Identification: Isolated from a genomic library using a bovine α_i1 cDNA probe.

(Schmidt et al., 1989)

Origin and Etymology

Discoverer

Etymology

The gene is named "brokenheart" based on the phenotype of mutant embryos.

(Fremion et al., 1999)

Identification

External Crossreferences and Linkouts ( 103 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

36104

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P16378

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

D5AEN0

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0001122

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0001122

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG2204

Flygut - An atlas of the Drosophila adult midgut

FBgn0001122

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

36104

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG2204

modMine - A data warehouse for the modENCODE project

FBgn0001122

Linkouts

BioGRID - A database of protein and genetic interactions.

61922

DPiM - Drosophila Protein interaction map

FBgn0001122

DroID - A comprehensive database of gene and protein interactions.

FBgn0001122

DRSC - Results frm RNAi screens

FBgn0001122

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0001122

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG2204-RB

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0001122

FlyMine - An integrated database for Drosophila genomics

FBgn0001122

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

36104

MIST (genetic) - An integrated Molecular Interaction Database

Galphao

MIST (protein-protein) - An integrated Molecular Interaction Database

Galphao

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (47)

Reported As

Symbol Synonym

Bkh

(Zaffran et al., 2001)

CG2204

(Honjo et al., 2016, Hanlon and Andrew, 2015, Rosa-Ferreira et al., 2015, Christis and Munro, 2012, Cammarato et al., 2011, Boto et al., 2010, Khanna et al., 2010, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Strub et al., 2008, Huang et al., 2007, Quinones-Coello, 2007, Colicelli, 2004)

DG_o

(Lee et al., 1990)

DGα0

DGα_o

(Schmidt et al., 1989)

DROGPAD

(Schlotterer et al., 1998, Schug et al., 1998, Schug et al., 1997)

G(o)α47A

(Madalan et al., 2012, Ferris et al., 2006)

G-oalpha

(Mack et al., 2006)

G-oalpha47A

(Ugrankar et al., 2018, Van Bortle et al., 2015, Ashwal-Fluss et al., 2014, Zhang et al., 2013, Murray et al., 2012, Friedman et al., 2011, Toku et al., 2011, Tan et al., 2009, Bakal et al., 2007, Buszczak et al., 2007, Minidorff et al., 2007, Quinones-Coello, 2007, Giot et al., 2003)

G-oα

(Hanlon and Andrew, 2015)

G-oα47A

(Song et al., 2018, Hanlon and Andrew, 2015, Muliyil and Narasimha, 2014, Tan et al., 2012, Dahdal et al., 2010, Mummery-Widmer et al., 2009, McGurk et al., 2008, Ogden et al., 2008, Strub et al., 2008, Yi et al., 2008, Stuart et al., 2007, Zhang et al., 2007, Mack et al., 2006)

G-oα47a

(Bandyopadhyay et al., 2006)

G-α-47A

G_o

(Ignatious Raja et al., 2014, Boto et al., 2010)

G_oα

(de Sousa et al., 1991)

G_oα

(Guillen et al., 1991)

Galpha47A

(Lum, 2003)

Galpha₀

(Kaltschmidt and Brand, 2002)

Galphao

(Mast and DiPrimio, 2019.3.13, Gene Disruption Project members, 2016-, Gene Disruption Project members, 2015-, Morozova et al., 2015, Tishchenko et al., 2013, Segalen et al., 2007)

Go

(Zhou et al., 2019, Katanaev et al., 2018, Yi et al., 2013, Bredendiek et al., 2011, Boto et al., 2010, Dahdal et al., 2010, Boto et al., 2007, Katanaev and Tomlinson, 2006, Katanaev and Tomlinson, 2005, Katanaev et al., 2005, Wolfgang et al., 1991)

Go-alpha

(Zaffran et al., 1995, Lineruth and Davis, 1992, Schmidt, 1992.2.10)

Goa

(Fremion et al., 1999, Fremion et al., 1998)

Goα

(Potdar and Sheeba, 2013, Yoshiura et al., 2012, Bredendiek et al., 2011, Guo et al., 2011, Chatterjee et al., 2009, Guillen et al., 1995, Horgan et al., 1995, Wolfgang et al., 1991, Wolfgang et al., 1990)

Goα-47A

(Wei et al., 2020)

Goα47a

(Singh et al., 2014)

Gα47A

(Schaefer et al., 2000)

Gα_047A

(Schweisguth, 2000)

Gα_o

(Cooper et al., 2011, Yao and Carlson, 2010, Ogden et al., 2008, Quaiser, 2006, Gonczy, 2002)

Gα_o47A

(Vecsey et al., 2014)

Gαi/o

(Krishnan et al., 2015)

Gαo47A

(Patel et al., 2016, Im et al., 2015, Yu et al., 2003)

alpha(o)

(Garen-Fazio et al., 1991)

bkh

(Singh and Mlodzik, 2012, Boto et al., 2010, Zaffran et al., 2006, Fremion et al., 1999, Fremion et al., 1999)

dGαo

(Solis et al., 2017)

dgo

(Hall et al., 2019, Shortridge et al., 1991, Yoon et al., 1989)

dgoα

(Buchner, 1991)

drogpad

(Boto et al., 2010)

goα

(Koon and Budnik, 2012)

like GNAO

(Krishnan et al., 2015)

Name Synonyms

Drogpad

(Schlötterer and Agis, 2002, Harr and Schlotterer, 2000)

G protein o alpha 47A

(Honjo et al., 2016)

G protein oalpha 47A

(Cammarato et al., 2011)

G protein oα 47A

(Tan et al., 2012, Khanna et al., 2010)

G protein α o subunit

brokenheart

(Singh and Mlodzik, 2012, Quaiser, 2006, Fremion et al., 1999, Fremion et al., 1999)

brokenhearted

(Fuse and Hirose, 2005, Cripps and Olson, 2002)

Secondary FlyBase IDs

FBgn0026838

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (205)