Gαs, Gs, Gsα, dgs, G-sα60A
s-α subunit of heterotrimeric G protein - regulates cyclic AMP second messenger system - functions in learning
Please see the JBrowse view of Dmel\Gαs for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.52
A non-AUG start codon may be used for translation of one or more transcripts of this gene; based on the presence of conserved protein signatures within the 5' UTR without an in-frame AUG (FBrf0243886).
1.9 (unknown)
G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gαs using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: reported as muscle system primordium
Comment: reported as muscle system primordium
G-sα60A transcript of 1.9 kb appears in 2-6 hr embryos, and persists at constant levels through embryonic, larval and pupal stages.
G-sα60A protein is associated with all cell membranes by germ band extension.
G-sα60A protein is detected in the cortex of follicle cells during oogenesis. Undetectable early in embryogenesis, it is detected after gastrulation, and is associated with all cell membranes by germ band extension.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Gαs in JBrowse
2-105
2-109.8
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
G-salpha60A signaling mediates odor identity discrimination in conditioned flies.
One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders.
G-sα60A is necessary for the death and resorption of wing blade cells after eclosion.
G-sα60A is required for growth and function of neuromuscular synapses.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
One of a class of genes with TATA-less promoters that have the conserved DPE sequence.
Olfactory learning depends on regulated Gs signalling in mushroom bodies.
Genetic studies indicate that the G-sα60A pathway mediates its primary effects by a novel pathway in differentiating wing epithelial cells.
Dominant adult phenotypes can be caused by the overexpression of activated Gα proteins.
G proteins belong to a family of membrane-associated guanine nucleotide-binding proteins that couple specific receptors for extracellular signals to specific intracellular effectors, thus regulating the activity of these effectors. When not interacting with the receptor, G proteins are usually in the form of a heterotrimer made up of α, β and γ subunits, with the α subunit bound to GDP. Upon activation by the receptor, the α subunit exchanges GDP for GTP, dissociates from the β-γ subunits and interacts with the effector. Afterwards GTP is hydrolyzed and the heterotrimer of α, β and γ subunits is formed again.
Identification: Isolated from a cDNA library using a bovine Gsα cDNA fragment as a probe.
Encodes a stimulatory G protein α subunit with high homology to mammalian Gsα that is responsible for the coupling of extracellular receptors to adenylate cyclase and an increase in the second messenger cAMP.
Source for identity of: G-sα60A CG2835
Source for identity of: Gαs G-sα60A
Genes encoding Gα subunits that have been named for their molecular function/orthology have had their symbols and names standardized following the format used in FBrf0220456, which also reflects popular usage in the Drosophila literature.
