GSI, Glutamine synthetase, mitochondrial glutamine synthetase
Gene model reviewed during 5.48
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.44
Gene model reviewed during 5.51
Low-frequency RNA-Seq exon junction(s) not annotated.
2.3, 2.2, 1.8 (northern blot)
399 (aa); 44.5 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gs1 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Gs1 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Gs1 and Gs2 have been isolated and sequenced. Evolutionary analysis is in agreement with the hypothesis that the two genes are derived from a duplication event that occurred near the time of divergence between Insecta and Vertebrata. Both isoforms catalyse all reactions catalysed by other glutamine synthetases, but the different kinetic parameters and the different cellular compartmentalisation suggests strong functional specialisation. Gs1 and Gs2 gene products are essential for the early stages of embryonic development. Preliminary results show strikingly distinct spatial and temporal patterns of expression of the two isoforms at later stages of development.
Mutations in Gs1 do not affect the Gs2 enzyme (Caggese et al., 1988).