FlyBase Gene Report: Dmel\Gs2

General Information

Symbol

Dmel\Gs2

Species

D. melanogaster

Name

Glutamine synthetase 2

Annotation Symbol

CG1743

Feature Type

protein_coding_gene

FlyBase ID

FBgn0001145

Gene Model Status

Current

Stock Availability

12 publicly available

Enzyme Name (EC)

Glutamine synthetase (6.3.1.2)

Gene Summary

Glutamine synthetase 2 (Gs2) encodes an enzyme that converts glutamate to glutamine. It is expressed in the embryonic nervous system and regulates the size of glutamate neurotransmitter pools and synapse assembly. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Red Book
Interactive Fly

Also Known As

GsII

Key Links

Genomic Location

Cytogenetic map

10B11-10B11

Sequence location

X:11,422,832..11,430,197 [+]

Recombination map

1-34

RefSeq locus

NC_004354 REGION:11422832..11430197

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (6 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables glutamate-ammonia ligase activity

inferred from direct assay

(Caggese et al., 1994)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables glutamate-ammonia ligase activity

inferred from biological aspect of ancestor with PANTHER:PTN000465001

(assigned by GO_Central )

(Gaudet et al., 2011)

non-traceable author statement

(Featherstone et al., 2002)

Biological Process (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

involved_in glutamate catabolic process

inferred from mutant phenotype

(Featherstone et al., 2002)

involved_in neurotransmitter receptor metabolic process

inferred from mutant phenotype

(Featherstone et al., 2002)

involved_in synapse assembly

inferred from mutant phenotype

(Featherstone et al., 2002)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in glutamine biosynthetic process

inferred from biological aspect of ancestor with PANTHER:PTN000465001

(assigned by GO_Central )

(Gaudet et al., 2011)

non-traceable author statement

(Featherstone et al., 2002)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000465001

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in cytoplasm

inferred from sequence or structural similarity with HGNC:4341

(Caggese et al., 1994)

Gene Group (FlyBase)

ACID-AMMONIA LIGASES

Protein Family (UniProt)

Belongs to the glutamine synthetase family. (P20478)

Protein Signatures (InterPro)

Catalytic Activity (EC)

Experimental Evidence

ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine (6.3.1.2)

Predictions / Assertions

ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine (6.3.1.2)

Summaries

Gene Snapshot

Gene Group (FlyBase)

ACID-AMMONIA LIGASES -: Acid-ammonia ligases catalyze the ligation of an acid to ammonia (NH3) or an amide via a carbon-nitrogen bond.

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

GsII: Glutamine synthetase II

Structural gene for glutamine synthetase II. Completely separable from glutamine synthetase I by DEAE chromatography. The GSII protein was purified from adult Drosophila (Scalenghe and Ritossa, 1976) and was isolated by sequence identity with the hamster gene (De Pinto et al., 1987). The enzyme is a multimer of a single subunit (MW 42,000). The complete enzyme has an approximate molecular weight of 360,000 and differs from the GSI enzyme in both subunit molecular weight and in isoelectric point. 90% of glutamine synthetase activity is due to GSII, which is the most abundant adult form.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Gs2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P20478)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Supported by strand-specific RNA-Seq data.

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Gs2-RA

FBtr0073496

NM_206685

1812

266

Gs2-RB

FBtr0073494

NM_167284

1906

369

Gs2-RC

FBtr0073495

NM_078568

1619

369

Gs2-RD

FBtr0343561

NM_001298192

1918

373

Gs2-RE

FBtr0343562

NM_001298193

1829

369

Gs2-RF

FBtr0343563

NM_001298194

1990

369

Additional Transcript Data and Comments

Reported size (kB)

2.0 (northern blot)

(Caizzi et al., 1990)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Gs2-PA

FBpp0089332

29.5

266

5.91

NP_996408

AAS65314

Gs2-PB

FBpp0073344

41.3

369

5.30

NP_727525

AAF48043

Gs2-PC

FBpp0073345

41.3

369

5.31

NP_511123

AAN09632

Gs2-PD

FBpp0310162

41.7

373

5.47

NP_001285121

AHN59591

Gs2-PE

FBpp0310163

41.3

369

5.31

NP_001285122

AHN59592

Gs2-PF

FBpp0310164

41.3

369

5.31

NP_001285123

AHN59593

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

369 aa isoforms: Gs2-PC, Gs2-PE, Gs2-PF

Additional Polypeptide Data and Comments

Reported size (kDa)

365 (aa); 41 (kD predicted)

(Caizzi et al., 1990)

Comments

External Data

Subunit Structure (UniProtKB)

Homooctamer.

(UniProt, P20478)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gs2 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Gs2_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 9 -- 10

amnioserosa

(Fisher et al., 2012)

yolk nucleus

(Fisher et al., 2012)

embryonic stage 11 -- 12

yolk nucleus

(Fisher et al., 2012)

embryonic stage 14 -- 17

longitudinal glial cell

(Kerr et al., 2014)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

first instar larval stage

(Caizzi et al., 1990)

second instar larval stage

(Caizzi et al., 1990)

adult stage

(Caizzi et al., 1990)

Additional Descriptive Data

The Gs2 transcript is abundant in first and second instar larvae and in adults.

(Caizzi et al., 1990)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

larval neuropil glial cell

(Losada-Perez et al., 2016)

pupal stage

precursor of adult central brain neuropil glia

(Losada-Perez et al., 2016)

adult stage

glial cell of spur of adult mushroom body

(Sinakevitch et al., 2010)

glial cell of lobe system of adult mushroom body

(Sinakevitch et al., 2010)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

(Sinakevitch et al., 2010)

adult brain

(Sinakevitch et al., 2010)

Additional Descriptive Data

Gs2 protein colocalizes with Eeat1 expression in glial cells in the spur of the adult mushroom body. Gs1 immunoreactivity is distributed over all mushroom body lobes, excepting the core neurons.

(Sinakevitch et al., 2010)

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: PBac{566.P.SVS-1}Gs2^CPTI100002

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult gnathal ganglion

(Knowles-Barley, 2011.8.24)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Gs2 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Gs2

View exonic expression by tissue for Dmel\Gs2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0001145

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32087/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0001145

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0001145

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0001145

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1743

Flygut - An atlas of the Drosophila adult midgut

FBgn0001145

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Gs2

Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 10 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Gs2

Transgenic constructs containing regulatory region of Gs2

Aberrations (Deficiencies and Duplications) ( 4 )

Inferred from experimentation ( 4 )

Gene disrupted in

Df(1)DA622

(Caggese et al., 1994)

Df(1)m13

(Caggese et al., 1994)

Df(1)N71

(Caggese et al., 1994, Caggese et al., 1986)

Df(1)RA37

(Caggese et al., 1994, Caggese et al., 1986)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal, with Scer\GAL4^tin.CΔ4

Gs2^GD9378

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Gs2^GD9378

viable, with Scer\GAL4^Mef2.PR

Gs2^GD9378

viable, with Scer\GAL4^pnr-MD237

Gs2^GD9378

Other Phenotypes

Allele

abnormal locomotor behavior | third instar larval stage, with Scer\GAL4^GMR83E12

Gs2^GD9378

abnormal neurophysiology

Gs2^m13

short lived | heat sensitive, with Scer\GAL4^tin.CΔ4

Gs2^GD9378

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\GLUL

14 of 15

Yes

Hsap\LGSN

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Glul

12 of 15

Yes

Mmus\Lgsn

1 of 15

Rattus norvegicus (Norway rat) (2)

Rnor\Glul

9 of 13

Yes

Rnor\Lgsn

1 of 13

Xenopus tropicalis (Western clawed frog) (4)

Xtro\glul

7 of 12

Yes

Xtro\glul

5 of 12

Yes

Xtro\lgsn

1 of 12

Yes

Xtro\LOC100498257

1 of 12

Yes

Danio rerio (Zebrafish) (5)

Drer\glula

13 of 15

Yes

Drer\glulb

12 of 15

Yes

Drer\glulc

9 of 15

Yes

Drer\lgsn

1 of 15

Drer\LOC100535016

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (5)

Cele\gln-3

14 of 15

Yes

Cele\gln-1

8 of 15

Yes

Cele\gln-5

8 of 15

Yes

Cele\gln-2

7 of 15

Yes

Cele\gln-6

6 of 15

Yes

Arabidopsis thaliana (thale-cress) (6)

Atha\GLN1.3

9 of 9

Yes

Atha\GLN1;4

8 of 9

Atha\GLN1;5

8 of 9

Yes

Atha\GS2

8 of 9

Yes

Atha\GSR 1

8 of 9

Atha\GSR2

8 of 9

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\GLN1

13 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\gln1

10 of 12

Yes

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (1)

Gene Symbol

Score

Source

Alignment

Gs1

7 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

GLUL; glutamate-ammonia ligase

14 of 15

138290

GLUTAMINE DEFICIENCY, CONGENITAL

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Gs2

x-ray crystallography, cosedimentation, molecular weight

(Chen et al., 2020)

Gs2 - Traf-like

two hybrid

(Hu et al., 2017.6.13)

RNA-protein

Physical Interaction

Assay

References

Gs2 - Sxl

electrophoretic mobility shift assay, autoradiography

(Banerjee and Singh, 2021)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

Homooctamer.

(UniProt, P20478 )

Linkouts

BioGRID - A database of protein and genetic interactions.

58498

DroID - A comprehensive database of gene and protein interactions.

FBgn0001145

MIST (protein-protein) - An integrated Molecular Interaction Database

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

L-glutamine biosynthesis I

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0001145

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-34

Cytogenetic map

10B11-10B11

Sequence location

X:11,422,832..11,430,197 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

10B11-10B11

Limits computationally determined from genome sequence between P{EP}CG11756^EP1610 and P{EP}CG32666^EP1452

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

10B-10B

(determined by in situ hybridisation)

(Caizzi et al., 1990)

10B8-10B11

(determined by in situ hybridisation)

(Caggese et al., 1986)

Experimentally Determined Recombination Data

Location

1-34

(FlyBase, 2016)

1-36.3

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (12)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

92838

w^*; P{UAS-Gs2.RNAi}221

12563

w¹¹¹⁸ P{GT1}Gs2^BG01223

6001

Df(1)m13, Gs2^m13/FM7a, w⁺

40949

y¹ v¹; P{TRiP.HMS02197}attP40

59704

y¹ w^* Mi{MIC}Gs2^MI14499

66847

y¹ w^* Mi{Trojan-GAL4.1}Gs2^{MI14499-TG4.1}

76492

y¹ sc^* v¹ sev²¹; P{TKO.GS00941}attP40

68135

y¹ sc^* v¹ sev²¹; P{TOE.GS00532}attP40/CyO

Kyoto

115073

w¹¹¹⁸ PBac{566.P.SVS-1}Gs2^CPTI100002

115528

w¹¹¹⁸ PBac{681.P.FSVS-1}Gs2^CPTI001918

VDRC

v330302

P{VSH330302}attP40

v32929

w¹¹¹⁸; P{GD9378}v32929

Genomic Clones (11)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (253)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_LP04559

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0001145

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0001145

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32087

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Gs2 CG1743

(Zhong, 1999.11)

Source for database merge of

Additional comments

Other Comments

Gs1 and Gs2 have been isolated and sequenced. Evolutionary analysis is in agreement with the hypothesis that the two genes are derived from a duplication event that occurred near the time of divergence between Insecta and Vertebrata. Both isoforms catalyse all reactions catalysed by other glutamine synthetases, but the different kinetic parameters and the different cellular compartmentalisation suggests strong functional specialisation. Gs1 and Gs2 gene products are essential for the early stages of embryonic development. Preliminary results show strikingly distinct spatial and temporal patterns of expression of the two isoforms at later stages of development.

(Caggese et al., 1994)

Gs2 has been cloned and sequenced.

(Caizzi et al., 1990)

Isolated from a genomic library using a DNA fragment comprising 80% of the coding region of glutamine synthetase from Chinese hamster ovary cells as a probe.

(Caggese et al., 1986)

Gs2 has been cloned.

(Caggese et al., 1986)

Structural gene for glutamine synthetase II. Completely separable from glutamine synthetase I by DEAE chromatography. The GSII protein was purified from adult Drosophila (Scalenghe and Ritossa, 1976) and was isolated by sequence identity with the hamster gene (De Pinto, Caggese, Prezioso and Ritossa, 1987). The enzyme is a multimer of a single subunit (MW 42,000). The complete enzyme has an approximate molecular weight of 360,000 and differs from the GSI enzyme in both subunit molecular weight and in isoelectric point. 90% of glutamine synthetase activity is due to GSII, which is the most abundant adult form.

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 71 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

32087

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P20478

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P20478

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P20478

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0001145

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0001145

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

32087/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0001145

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Gs2_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0001145

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0001145

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1743

Flygut - An atlas of the Drosophila adult midgut

FBgn0001145

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0001145

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

32087

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC002601

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG1743

MARRVEL_MODEL - MARRVEL (model organism gene)

32087

modMine - A data warehouse for the modENCODE project

FBgn0001145

Linkouts

BioGRID - A database of protein and genetic interactions.

58498

DroID - A comprehensive database of gene and protein interactions.

FBgn0001145

DRSC - Results frm RNAi screens

FBgn0001145

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0001145

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

L-glutamine biosynthesis I

FlyMine - An integrated database for Drosophila genomics

FBgn0001145

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

MIST (protein-protein) - An integrated Molecular Interaction Database

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (14)

Reported As

Symbol Synonym

CG1743

(Meadows, 2017.1.11, Rosa-Ferreira et al., 2015, Ni et al., 2010.12.1, Baltzer et al., 2009, Mohammad et al., 2009, Pan and Zhang, 2009, Nair et al., 2007, Fulton et al., 2001)

DmGS2

(Chen et al., 2020)

GS2

(Otto et al., 2018, de la Cova et al., 2014, Kato et al., 2011, Rees et al., 2011, Sinakevitch et al., 2010, Caizzi, 1992.12.2, Caizzi et al., 1990)