FlyBase Gene Report: Dmel\gsb

PAIRED HOMEOBOX TRANSCRIPTION FACTORS -: Paired homeobox transcription factors are sequence-specific DNA binding proteins that regulate transcription. They have a characteristic paired domain in association with the homeodomain. (Adapted from FBrf0135231 and PMID:1672661).

Protein Function (UniProtKB)

Expressed in segmentally repeating pattern to define the polarity of embryonic segments.

(UniProt, P09082)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

gsb: gooseberry

Homozygous lethal; embryos show segment-polarity defects. The posterior portion of each segment is deleted and the anterior portion duplicated in mirror image fashion; the ventral segments are almost entirely covered with denticles, the posterior fraction of which point anteriorly. Segment boundaries persist normally and segments maintain their individuality. The mutants show alterations in the identity of neurons, both underneath and outside the modified ectoderm (Patel, Schafer, Goodman, and Holmgren, 1989, Genes Dev. 3: 890-904); posterior commissures are almost totally absent.

Summary (Interactive Fly)

transcription factor - homeodomain - paired domain - regulates neuroblast cell fate

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\gsb or the JBrowse view of Dmel\gsb for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

gsb-RA

FBtr0072444

NM_079139

1649

427

Additional Transcript Data and Comments

Reported size (kB)

2.6, 2.4, 1.8 (northern blot)

(Baumgartner et al., 1987)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

gsb-PA

FBpp0072349

45.5

427

9.52

NP_523863

AAF47315

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

427 (aa)

(Baumgartner et al., 1987)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

P09082

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\gsb using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

gsb_1

Linkouts

Gene Ontology (10 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

RNA polymerase II regulatory region sequence-specific DNA binding

inferred from direct assay

(Li and Noll, 1994)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (7 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

chemical synaptic transmission

inferred from direct assay

(Marie et al., 2010)

neurogenesis

inferred from mutant phenotype

(He and Noll, 2013)

inferred from genetic interaction with FLYBASE:gsb-n; FB:FBgn0001147

(He and Noll, 2013)

regulation of synaptic activity

inferred from direct assay

(Marie et al., 2010)

salivary gland morphogenesis

inferred from mutant phenotype

(Vining et al., 2005)

segment polarity determination

inferred from genetic interaction with FLYBASE:gsb-n; FB:FBgn0001147

(He and Noll, 2013)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

regulation of transcription, DNA-templated

inferred from electronic annotation with InterPro:IPR001523, InterPro:IPR017970

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

segment polarity determination

non-traceable author statement

(Davis and Patel, 2003)

ventral cord development

traceable author statement

(Skeath and Thor, 2003)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

cytoplasm

inferred from mutant phenotype

(Vining et al., 2005)

nucleus

inferred from mutant phenotype

(Vining et al., 2005)

Terms Based on Predictions or Assertions (0 terms)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 5 -- 7

organism | pair rule expression pattern

(Nasiadka and Krause, 1999)

embryonic stage 4 -- 6

central brain anlage in statu nascendi

(Fisher et al., 2012)

dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

hypopharynx anlage in statu nascendi

(Fisher et al., 2012)

organism | segmentally repeated

(Fisher et al., 2012)

ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

antennal anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

dorsal head epidermis anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

visual anlage in statu nascendi

Comment: reported as procephalic ectoderm anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 7 -- 8

antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

visual anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal ectoderm

(Fisher et al., 2012)

hypopharynx anlage

(Fisher et al., 2012)

organism | segmentally repeated

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

antennal primordium

(Fisher et al., 2012)

dorsal ectoderm

(Fisher et al., 2012)

hypopharynx inclusive primordium

(Fisher et al., 2012)

organism | segmentally repeated

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

antennal primordium

(Fisher et al., 2012)

clypeo-labral primordium

(Fisher et al., 2012)

hypopharynx proper primordium

(Fisher et al., 2012)

organism | segmentally repeated

(Fisher et al., 2012)

ventral epidermis primordium

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic anal pad

(Fisher et al., 2012)

embryonic hypopharynx

(Fisher et al., 2012)

embryonic ventral epidermis

(Fisher et al., 2012)

organism | segmentally repeated

(Fisher et al., 2012)

embryonic stage

ventral midline

(Wheeler et al., 2009)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 9 -- 12

Comment: reference states 4-8 hr AEL

(Baumgartner et al., 1987)

radioisotope in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic cycle 14A

organism | 70-80% egg length

Comment: reference states 75% egg length

(Baumgartner et al., 1987)

organism | 70% egg length

(Baumgartner et al., 1987)

gastrula stage -- extended germ band stage

organism | striped

(Cote et al., 1987, Bopp et al., 1986)

embryonic stage 17

embryonic/larval pharynx | restricted

(Baumgartner et al., 1987)

anal pad

(Baumgartner et al., 1987)

embryonic stage 10 -- 12

mesoderm

(Baumgartner et al., 1987)

embryonic stage 10 -- 14

ectoderm

(Baumgartner et al., 1987)

embryonic stage 5 -- 13

organism | anterior

(Cote et al., 1987)

embryonic stage 13

ventral nerve cord | anterior

Comment: early embryonic stage 13

(Baumgartner et al., 1987)

embryonic stage 5 -- 17

head segment | segmentally repeated

(Baumgartner et al., 1987)

thoracic segment | posterior | segmentally repeated

(Baumgartner et al., 1987)

abdominal segment 1 -- abdominal segment 11

Comment: posterior & segmentally repeated

(Baumgartner et al., 1987)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

neuroblast | subset

Comment: row 5 neuroblast

(Chu-LaGraff and Doe, 1993)

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 9 -- 13

abdominal segment 9 -- abdominal segment 11

(Gutjahr et al., 1993)

embryonic stage 10 -- 12

neuroblast

(Gutjahr et al., 1993)

mesoderm

(Gutjahr et al., 1993)

embryonic stage 10

ventral neurectoderm | segmentally repeated

(Gutjahr et al., 1993)

organism | striped

(Bouchard et al., 2000)

embryonic stage 4 -- 13

organism | segmentally repeated

(Gutjahr et al., 1993)

embryonic stage 14

anal pad | restricted

(Gutjahr et al., 1993)

embryonic/larval pharynx | restricted

(Gutjahr et al., 1993)

third instar larval stage

male genital disc | restricted

(Freeland and Kuhn, 1996)

female genital disc | restricted

(Freeland and Kuhn, 1996)

embryonic stage 8 -- 13

embryonic intercalary segment

(Gutjahr et al., 1993)

embryonic stage 11

tritocerebral neuroblast | subset

(Urbach and Technau, 2003)

organism | striped

(Bouchard et al., 2000)

organism | segment polarity expression pattern

(Bouchard et al., 2000)

embryonic stage 8 -- 11

ventral neurectoderm & embryonic ocular segment | restricted

(Urbach and Technau, 2003)

ventral neurectoderm & embryonic antennal segment | anterior | restricted

(Urbach and Technau, 2003)

embryonic stage 10 -- 13

labral segment | restricted

(Gutjahr et al., 1993)

blastoderm stage

parasegment | subset

Comment: odd parasegments

(Li et al., 1993)

embryonic stage 6 -- 17

epidermis | segmentally repeated

(Li et al., 1993)

embryonic segment posterior compartment

(Li et al., 1993)

embryonic stage 12 -- 13

trunk mesoderm of embryonic thoracic segment

(Li et al., 1993)

embryonic stage 13

abdominal segment motor neuron | subset of segmental nerve branch SNa of A1-7

(He and Noll, 2013)

Additional Descriptive Data

gsb-protein is expressed in medial SNa motor neurons which derive from NB5-4 and co-express B-H1.

(He and Noll, 2013)

gsb-d protein is expressed in a segmental pattern in the procephalic region with stripes of expression corresponding to and anterior to and partly overlap those of en in this region. These regions produce neuroblasts primarily in the deuto and tritocerbrum with a single protocerbral neuroblast expressing gsb.

(Urbach and Technau, 2003)

Expression in procephalic neuroblasts stage 9-11: tritocerebrum - d2-4, v3; deuterocerebrum - d1, d5, d7; protocerebrum - pd3, pd10

(Urbach and Technau, 2003)

gsb protein was used as a neuroblast marker. It is expressed in rows 5 and 6/7 neuroblasts.

(Chu-LaGraff and Doe, 1993)

gsb protein is detected in a segmentally repeated pattern a the end of cellularization. Odd-numbered stripes 1-13 plus an anterior stripe 0 appear first, and are followed by the appearance of even stripes 2-12 at mid-gastrulation, and of stripe 14 at the start of germ band extension. Towards the end of germ band extension, stripes 4-14 become restricted to neurectoderm. gsb protein expression is highest at this stage, with expression also detected in 4 anterior and 3 posterior regions. Expression is also detected in the most medial neuroblasts of row 5. Anterior and posterior accumulation decreases after this stage. At the end of germ band retraction, ectodermal expression increases once more, to disappear again by stage 14. During germ band extension, all neuroblasts of row 5 and 6 express gsb-n protein, and those of row 7 express it transiently. Additional cells which may be the VUM precursors also express gsb-n protein transiently. Low levels of expression persist in a few neuroblasts and ganglion mother cells until germ band retraction. Mesodermal gsb-n protein expression is first detected at mid-germ-band extension, persists in three patches in thoracic segments that subsequently merge, and dissapears around head involution. Intercalary segment primordium expression is detected starting at mid germ band extension. Expression is detected in a dorsal patch of the labral segment and in additional patches in the presumptive head during the slow phase of germ band extension. Additional stripes (stripes 15-17) appear in the tail region during germ band extension. gsb-n protein is expressed transiently in the pharynx and anal pad during head involution.

(Gutjahr et al., 1993)

Marker for

Subcellular Localization

CV Term

Evidence

References

cytoplasm

inferred from mutant phenotype

(Vining et al., 2005)

nucleus

inferred from mutant phenotype

(Vining et al., 2005)

Expression Deduced from Reporters

Reporter: P{9Z3}

Stage

Tissue/Position (including subcellular localization)

Reference

blastoderm stage

parasegment | subset

Comment: odd parasegments

(Li et al., 1993)

embryonic stage 6 -- 17

organism | segmentally repeated

(Li et al., 1993)

embryonic segment posterior compartment

(Li et al., 1993)

embryonic stage 12 -- 13

trunk mesoderm of embryonic thoracic segment

(Li et al., 1993)

Reporter: P{gsb-lacZ.IV}

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 6 -- 11

organism | segment polarity expression pattern

(Bouchard et al., 2000)

Reporter: P{PZ}gsb⁰¹¹⁵⁵

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

embryonic/larval central nervous system | restricted

(Marie et al., 2010)

motor neuron | subset

(Marie et al., 2010)

first instar larval stage

larval abdominal ganglion Leucokinin neuron

(Benito-Sipos et al., 2010)

abdominal ventro-medial neuroblast

(Estacio-Gómez et al., 2013)

abdominal ventro-lateral neuroblast

(Estacio-Gómez et al., 2013)

adult stage

adult abdominal ganglion Leucokinin neuron

(Estacio-Gómez et al., 2013)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\gsb in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\gsb

View exonic expression by tissue for Dmel\gsb

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0001148

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0001148

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG3388-RA

Flygut - An atlas of the Drosophila adult midgut

FBgn0001148

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\gsb

Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 10 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 29 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of gsb

Transgenic constructs containing regulatory region of gsb

Deletions and Duplications ( 7 )

Not disrupted in

Df(2R)bw^VDe2LPx^KR

(Spradling et al., 1999, Beaton, 1997.12.27)

Df(2R)M60E

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Partially disrupted in

Df(2R)gsb^db

(He and Noll, 2013)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

gsb^N.prd

lethal | heat sensitive

gsb^hs.PZ

lethal | recessive

gsb⁰¹¹⁵⁵

lethal - all die before end of embryonic stage | heat sensitive

gsb^hs.PBH

lethal - all die before end of embryonic stage | recessive

gsb⁰¹¹⁵⁵

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

gsb^GD1600

viable, with Scer\GAL4^pnr-MD237

gsb^GD1600

viable, with Scer\GAL4^tin.CΔ4

gsb^GD1600

Other Phenotypes

Allele

flight defective, with Scer\GAL4^Mef2.PR

gsb^GD1600

pair rule phenotype | embryonic stage

gsb^hs.PBH

some die during embryonic stage | heat sensitive

gsb^hs.PBH

some die during embryonic stage | recessive

gsb⁰¹¹⁵⁵

visible, with Scer\GAL4^Bx-MS1096

gsb^{UAS.ORF.GW.Tag:HA}

visible, with Scer\GAL4^ey.PH

wild-type

wild-type, with Scer\GAL4^ey.PH

Phenotype manifest in

Allele

abdominal 1 ventral denticle belt | heat sensitive

gsb^hs.PBH

abdominal 2 ventral denticle belt | embryonic stage

gsb^hs.PBH

abdominal 2 ventral denticle belt | heat sensitive

gsb^hs.PBH

abdominal 3 ventral denticle belt | heat sensitive

gsb^hs.PBH

abdominal 4 ventral denticle belt | embryonic stage

gsb^hs.PBH

abdominal 4 ventral denticle belt | heat sensitive

gsb^hs.PBH

abdominal 5 ventral denticle belt | heat sensitive

gsb^hs.PBH

abdominal 6 ventral denticle belt | embryonic stage

gsb^hs.PBH

abdominal 6 ventral denticle belt | heat sensitive

gsb^hs.PBH

abdominal 7 ventral denticle belt | heat sensitive

gsb^hs.PBH

abdominal 8 ventral denticle belt | embryonic stage

gsb^hs.PBH

aCC neuron

gsb^IIX62

aCC neuron | heat sensitive

gsb^hs.PZ

adult head, with Scer\GAL4^ey.PH

antenna, with Scer\GAL4^ey.PH

cuticle

gsb⁰¹¹⁵⁵

denticle belt

gsb⁰¹¹⁵⁵

denticle belt | ectopic

EL neuron

gsb^hs.PBH

embryonic central nervous system & neuroblast

gsb^IIX62

embryonic central nervous system & neuroblast | conditional ts

gsb^hs.PZ

embryonic dorsal epidermis

gsb^IIX62

embryonic epidermis | heat sensitive

gsb^hs.PZ

embryonic head

gsb^IIX62

embryonic segment posterior compartment

epidermis

gsb⁵²⁵

eye, with Scer\GAL4^ey.PH

Keilin's organ | heat sensitive

gsb^hs.PZ

neuroblast MP2

gsb^hs.PZ

neuroblast NB4-2

gsb⁵²⁵

neuroblast NB6-4

gsb^IIX62

neuroblast NB6-4 | ectopic, with Scer\GAL4^en-e16E

gsb^UAS.cDa

neuroblast NB7-3, with Scer\GAL4^en-e16E

gsb^UAS.cDa

neuroblast NB7-3 | ectopic

gsb^IIX62

pCC neuron

gsb^IIX62

pCC neuron | heat sensitive

gsb^hs.PZ

posterior commissure

presumptive embryonic salivary gland

gsb⁵²⁵

presumptive embryonic salivary gland, with Scer\GAL4^twi.PG

gsb^UAS.cJa

presumptive embryonic salivary gland (with Df(2R)gsb)

gsb⁵²⁵

RP2 motor neuron

RP2 motor neuron | ectopic

gsb^unspecified

RP2sib neuron

gsb^hs.PBH

RP2sib neuron | ectopic

gsb^unspecified

wing, with Scer\GAL4^Bx-MS1096

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v7.1)

Homo sapiens (Human) (10)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\PAX3

8 of 15

Yes

Hsap\PAX7

7 of 15

Hsap\DUX4

1 of 15

Yes

Hsap\MIXL1

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v7.1)

Mus musculus (laboratory mouse) (15)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Pax3

7 of 15

Yes

Mmus\Pax7

7 of 15

Yes

Mmus\Cphx1

1 of 15

Mmus\Cphx3

1 of 15

Yes

Mmus\Duxbl1

1 of 15

Yes

Mmus\Duxbl2

1 of 15

Yes

Mmus\Duxbl3

1 of 15

Yes

Mmus\Gm4981

1 of 15

Yes

Mmus\Mixl1

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (8)

Rnor\Pax3

7 of 13

Yes

Rnor\Pax7

7 of 13

Yes

Rnor\Dux4

1 of 13

Yes

Rnor\Mixl1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (10)

Xtro\pax3

7 of 12

Yes

Xtro\pax7

4 of 12

Xtro\bix1.1

1 of 12

Yes

Xtro\LOC100491743

1 of 12

Yes

Xtro\mixl1

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (14)

Drer\pax3a

8 of 15

Yes

Drer\pax3b

7 of 15

Drer\pax7a

5 of 15

Yes

Drer\pax7b

5 of 15

Drer\mixl1

1 of 15

Yes

Drer\mxtx1

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (11)

Cele\pax-3

4 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Arabidopsis thaliana (thale-cress) (4)

Atha\HB-1

1 of 9

Yes

Atha\HB-7

1 of 9

Yes

Atha\HB-12

1 of 9

Yes

Atha\HB52

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190B89 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA17419

Drosophila persimilis

Dper\GL17644

Drosophila willistoni

Dwil\GK21576

Drosophila virilis

Dvir\GJ21022

Drosophila mojavensis

Dmoj\GI21167

Drosophila grimshawi

Dgri\GH22657

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091506LL )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17013955

Musca domestica

House fly

Mdoa\17013956

Musca domestica

House fly

Mdoa\17025417

Glossina morsitans

Tsetse fly

Gmor\GMOY005892

Glossina morsitans

Tsetse fly

Gmor\GMOY001037

Glossina morsitans

Tsetse fly

Gmor\GMOY005893

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_02945

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_02914

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_02912

Mayetiola destructor

Hessian fly

Mdes\Mdes014706

Mayetiola destructor

Hessian fly

Mdes\Mdes015783

Mayetiola destructor

Hessian fly

Mdes\Mdes009107

Anopheles darlingi

American malaria mosquito

Adar\ADAC005776

Anopheles darlingi

American malaria mosquito

Adar\ADAC007025

Anopheles gambiae

Malaria mosquito

Agam\AGAP010359

Anopheles gambiae

Malaria mosquito

Agam\AGAP010358

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ006496

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ014198

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W09TG )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA013359

Bombyx mori

Silkmoth

Bmor\BGIBMGA000787

Bombyx mori

Silkmoth

Bmor\BGIBMGA013358

Bombyx mori

Silkmoth

Bmor\BGIBMGA009025

Danaus plexippus

Monarch butterfly

Dple\DPOGS216059-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS214473-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS214474-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS212842-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS216048-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL003749

Heliconius melpomene

Postman butterfly

Hmel\HMEL004481

Heliconius melpomene

Postman butterfly

Hmel\HMEL015048

Heliconius melpomene

Postman butterfly

Hmel\HMEL015047

Apis florea

Little honeybee

Aflo\2343747636

Apis florea

Little honeybee

Aflo\2865844996

Apis florea

Little honeybee

Aflo\4720701908

Apis florea

Little honeybee

Aflo\2147493041

Apis florea

Little honeybee

Aflo\3671096548

Apis florea

Little honeybee

Aflo\2167044690

Apis mellifera

Western honey bee

Amel\Pax-1

Apis mellifera

Western honey bee

Amel\LOC411374

Apis mellifera

Western honey bee

Amel\LOC411373

Apis mellifera

Western honey bee

Amel\Prd

Apis mellifera

Western honey bee

Amel\GB53162

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP24352

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP13822

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP19750

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP12026

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP24354

Bombus terrestris

Buff-tailed bumblebee

Bter\15206117

Bombus terrestris

Buff-tailed bumblebee

Bter\15216105

Bombus terrestris

Buff-tailed bumblebee

Bter\15204464

Bombus terrestris

Buff-tailed bumblebee

Bter\15215547

Linepithema humile

Argentine ant

Lhum\LH21528

Linepithema humile

Argentine ant

Lhum\LH25546

Linepithema humile

Argentine ant

Lhum\LH21527

Linepithema humile

Argentine ant

Lhum\LH25622

Linepithema humile

Argentine ant

Lhum\LH16584

Linepithema humile

Argentine ant

Lhum\LH16582

Linepithema humile

Argentine ant

Lhum\LH16581

Linepithema humile

Argentine ant

Lhum\LH14615

Linepithema humile

Argentine ant

Lhum\LH15339

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0010d5

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:00252d

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000d38

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000d37

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:0007af

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG002995

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG014844

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG022761

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_12494

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_12760

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_12360

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_12759

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_12361

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_10902

Tribolium castaneum

Red flour beetle

Tcas\sv

Tribolium castaneum

Red flour beetle

Tcas\prd

Tribolium castaneum

Red flour beetle

Tcas\Poxm

Tribolium castaneum

Red flour beetle

Tcas\gsb

Tribolium castaneum

Red flour beetle

Tcas\gsb-n

Pediculus humanus

Human body louse

Phum\PHUM375940

Pediculus humanus

Human body louse

Phum\PHUM515110

Pediculus humanus

Human body louse

Phum\PHUM134580

Pediculus humanus

Human body louse

Phum\PHUM596310

Pediculus humanus

Human body louse

Phum\PHUM596300

Rhodnius prolixus

Kissing bug

Rpro\RPRC008887

Rhodnius prolixus

Kissing bug

Rpro\RPRC009438

Rhodnius prolixus

Kissing bug

Rpro\RPRC001909

Rhodnius prolixus

Kissing bug

Rpro\RPRC001180

Rhodnius prolixus

Kissing bug

Rpro\RPRC001908

Cimex lectularius

Bed bug

Clec\CLEC002253

Cimex lectularius

Bed bug

Clec\CLEC006620

Cimex lectularius

Bed bug

Clec\CLEC009744

Cimex lectularius

Bed bug

Clec\CLEC012019

Cimex lectularius

Bed bug

Clec\CLEC006618

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI002777

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI067723

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI005583

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI004907

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI000633

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0HFF )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR007866

Strigamia maritima

European centipede

Smar\SMAR013763

Strigamia maritima

European centipede

Smar\SMAR008441

Strigamia maritima

European centipede

Smar\SMAR015380

Ixodes scapularis

Black-legged tick

Isca\ISCW003096

Ixodes scapularis

Black-legged tick

Isca\ISCW006352

Ixodes scapularis

Black-legged tick

Isca\ISCW014979

Ixodes scapularis

Black-legged tick

Isca\ISCW011634

Ixodes scapularis

Black-legged tick

Isca\ISCW021772

Stegodyphus mimosarum

African social velvet spider

Smim\KFM66998.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM62957.1

Stegodyphus mimosarum

African social velvet spider

Smim\KFM76871.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur29g01000

Tetranychus urticae

Two-spotted spider mite

Turt\tetur09g00660

Tetranychus urticae

Two-spotted spider mite

Turt\tetur07g04480

Tetranychus urticae

Two-spotted spider mite

Turt\tetur18g01460

Tetranychus urticae

Two-spotted spider mite

Turt\tetur29g00530

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_65647

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_311027

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_334067

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_9094

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_38922

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_45999

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_307722

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_15023

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_249978

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_265088

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_118064

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_122807

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_311028

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_249991

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_7942

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0S4E )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-PaxA

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Pax6_1

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Alx

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-PaxB

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Pax2-5-8

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Pax6

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Hbn

Ciona intestinalis

Vase tunicate

Cint\pax2/5/8-b

Ciona intestinalis

Vase tunicate

Cint\LOC778727

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000024971

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000012916

Ciona intestinalis

Vase tunicate

Cint\pax6

Gallus gallus

Domestic chicken

Ggal\PAX2

Gallus gallus

Domestic chicken

Ggal\PAX7

Gallus gallus

Domestic chicken

Ggal\PAX5

Gallus gallus

Domestic chicken

Ggal\PAX6

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000028576

Gallus gallus

Domestic chicken

Ggal\PAX9

Gallus gallus

Domestic chicken

Ggal\ENSGALG00000005246

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v7.1)

Drosophila melanogaster (Fruit fly) (23)

Gene Symbol

Score

Source

Alignment

5 of 10

prd

4 of 10

3 of 10

eyg

3 of 10

Poxn

3 of 10

toe

3 of 10

Poxm

2 of 10

toy

2 of 10

1 of 10

CG9876

1 of 10

CG11294

1 of 10

CG32532

1 of 10

eve

1 of 10

Gsc

1 of 10

otp

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 5 )

Human Ortholog

Disease

Evidence

References

PAX3; paired box 3

model of Waardenburg syndrome type 1

IEA

(FlyBase, 2019-)

model of craniofacial-deafness-hand syndrome

IEA

(FlyBase, 2019-)

model of alveolar rhabdomyosarcoma

IEA

(FlyBase, 2019-)

model of Waardenburg syndrome type 3

IEA

(FlyBase, 2019-)

PAX7; paired box 7

model of alveolar rhabdomyosarcoma

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

8 of 15

7 of 15

alveolar rhabdomyosarcoma

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

gsb - Fbp2

experimental knowledge based

(Guruharsha et al., 2011)

gsb - Rab14

experimental knowledge based

(Guruharsha et al., 2011)

gsb - βTub85D

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

gsb

suppressible

CycE

(Jiao et al., 2001)

gsb

suppressible

(Jiao et al., 2001)

gsb

suppressible

Myc

(Jiao et al., 2001)

GluRIIA|gsb

suppressible

(Marie et al., 2010)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

GluRIIA

suppressible

gsb

(Marie et al., 2010)

GluRIIA|wg

suppressible

gsb

(Marie et al., 2010)

prd

suppressible

gsb

(Xue and Noll, 2002, Xue et al., 2001)

suppressible

gsb

(Bhat, 1996)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

63573

DroID - A comprehensive database of gene and protein interactions.

FBgn0001148

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

38005

MIST (genetic) - An integrated Molecular Interaction Database

MIST (protein-protein) - An integrated Molecular Interaction Database

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-107

Cytogenetic map

60F2-60F2

Sequence location

2R:25,061,964..25,064,643 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

60F2-60F2

Limits computationally determined from genome sequence between P{EP}CG2790^EP412&P{EP}CG3776^EP835 and P{EP}zip^EP856&P{PZ}l(2)10481⁰³²⁶³

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

60F1-60F3

(determined by in situ hybridisation)

(Spradling et al., 1999, Perrimon et al., 1996, BDGP Project Members, 1994-1999)

60F1-60F3

(Beaton, 1997.12.27)

60F1-60F1

(determined by in situ hybridisation)

(Baumgartner et al., 1987)

60E9-60F1

(determined by in situ hybridisation)

(Cote et al., 1987)

60E9-60F2

(determined by in situ hybridisation)

(Bopp et al., 1986)

Experimentally Determined Recombination Data

Location

2-107

(FlyBase, 2016, Tearle and Nusslein-Volhard, 1987)

2-111.8

(Comeron et al., 2012)

2-107.6

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (11)

Bloomington

29600

y¹ v¹; P{TRiP.JF03279}attP2

44548

y¹ v¹; P{TRiP.HMC02944}attP2

10999

cn¹ P{PZ}gsb⁰¹¹⁵⁵/CyO; ry⁵⁰⁶

80182

y¹ sc^* v¹ sev²¹; P{TOE.GS02326}attP40

80769

y¹ sc^* v¹ sev²¹; P{TOE.GS02391}attP40

2528

Df(2R)gsb, cn¹ bw¹ zip^IIX62 gsb^IIX62/CyO

FlyORF

F000603

M{UAS-gsb.ORF.3xHA.GW}ZH-86Fb

Kyoto

107384

y^* w^*; Df(2R)gsb, cn¹ bw¹ zip^IIX62 gsb^IIX62/SM1, sp²

VDRC

v107940

P{KK112553}VIE-260B

v9277

w¹¹¹⁸; P{GD1600}v9277/TM3

v318024

PBac{fTRG00058.sfGFP-TVPTBF}VK00033

Genomic Clones (14)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (10)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences

BDGP DGC clones

IP01408

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0001148

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0001148

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

38005

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Gutjahr et al., 1993)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Additional comments

Other Comments

Transcription of gsb-n depends largely, but not completely, on the expression of the gsb product.

(He and Noll, 2013)

Both gsb-n and gsb are involved in specification of the SNa motor neurons, but gsb appears to play the more important role (since while two doses of gsb or gsb-n are required to properly determine SNa fate, one of the doses must be gsb, whereas gsb-n is dispensible when two copies of gsb are present). gsb and gsb-n have partially redundant functions in embryonic segmentation.

(He and Noll, 2013)

gsb is not required for the rapid induction of synaptic homeostasis.

(Marie et al., 2010)

gsb antagonizes wg signaling during embryonic cell fate specification and synaptic homeostasis.

(Marie et al., 2010)

Segment polarity gene expression is necessary for the survival of specific rows of epidermal cells.

(Pazdera et al., 1998)

CrebA gsb double mutant phenotype confirms that CrebA is not involved in segment polarity.

(Andrew et al., 1997)

Either en or inv is required to uncouple the ptc-gsb regulatory circuit in row 5 neuroblasts during neurogenesis.

(Bhat and Schedl, 1997)

gsb antagonises the wg signal that confers neuroblast 4-2 fate.

(Duman-Scheel et al., 1997)

Novel gsb mutants are isolated that exhibit CNS defects but have only weak or no segmentation defects.

(Duman-Scheel et al., 1997)

ptc and gsb interact during specification of the NB4-2 identity, but not during delamination of NB4-2 from the neuroectoderm.

(Bhat, 1996)

Loss of gsb function transforms NB5-3 to NB4-2 thus duplicating the RP2 lineage. The autocrine wg signal is responsible for conferring NB4-2 identity to NB5-3 in mutants.

(Bhat, 1996)

ptc signalling pathway directly represses the gsb expression in row 4 neuroblasts and their precursor neuroectoderm.

(Bhat, 1996)

The expression pattern of a number of genes in the larval genital discs, including gsb, has been studied to determine the segment-parasegment organisation of the genital discs.

(Freeland and Kuhn, 1996)

Four segment polarity genes, hh, wg, gsb and en all function in concert to determine the formation and specifications of three hh-dependent eg-neuroblasts (6-4, 7-3 and 2-4).

(Matsuzaki and Saigo, 1996)

gsb and prd show functional equivalence; gsb is able to substitute for all functions of prd required to support development to adults.

(Xue and Noll, 1996)

gsb expression is lineage specific suggesting that gsb functions as a selector gene in the patterning of the CNS.

(Buenzow and Holmgren, 1995)

gsb is necessary and sufficient to specify row 5 neuroblast identity autonomously.

(Skeath et al., 1995)

Lack of gsb transforms row 5 neuroblasts into row 3 neuroblasts whereas ubiquitous expression generates the reciprocal transformation.

(Skeath et al., 1995)

gsb and gsb-n both share the same upstream sequence which includes the enhancer elements for gsb and gsb-n.

(Li and Noll, 1994)

Ectopic expression analysis demonstrates that the gsb gene product can substitute the function of the prd gene product during early embryonic development and prd gene product can substitute gsb gene product during late embryonic development in regulating expression of wg and en.

(Li and Noll, 1994)

Comparisons of early development to that in other insects have revealed conservation of some aspects of development, as well as differences that may explain variations in early patterning events.

(Patel, 1994)

Repeated pulses of ptc lead to transcriptional repression of the segment polarity genes wg and gsb in the embryonic trunk and a wg like phenotype in the larval cuticle.

(Schuske et al., 1994)

Ectopic expression of either gsb or gsb-n protein causes cell fate transformations that are reciprocal to those of a gooseberry deletion mutant. gsb protein is required for the specification of naked cuticle in the epidermis and specific neuroblasts in the CNS.

(Zhang et al., 1994)

gsb transactivates gsb-n, and is sufficient to rescue the gsb phenotype in the absence of gsb-n.

(Gutjahr et al., 1993)

The main function of the gsb is the maintenance of wg expression by a wg-gooseberry autoregulatory loop after 6 hours of development. A temporal asymmetry in the regulatory interactions between wg, en and the gsb explains the difference in phenotypes between the mutants.

(Li and Noll, 1993)

The establishment and maintenance of gsb stripes is under the control of two separable and consecutively acting cis-regulatory elements, the gsb-early element, or GEE, and the gsb-late element, or GLE. The GEE is activated by pair-rule proteins, to establish the gsb stripes while the GLE controls their maintenance in response to the wg signal rather than to the gsb protein itself.

(Li et al., 1993)

Mirror segmentation phenotype of mutant embryos (Df(2R)gsb) is not altered by wg^hs.PN.

(Sampedro et al., 1993)

gsb, gsb-n mutants are homozygous lethal; embryos show segment-polarity defects. The posterior portion of each segment is deleted and the anterior portion duplicated in mirror image fashion; the ventral segments are almost entirely covered with denticles, the posterior fraction of which point anteriorly. Segment boundaries persist normally and segments maintain their individuality.

(Lindsley and Zimm, 1992)

gsb and nkd segment polarity gene products are responsible for maintaining the AP borders of ac expressing ectodermal cell clusters.

(Skeath et al., 1992)

gsb cannot completely rescue the ptc phenotype when in double mutant combinations.

(Hidalgo, 1991)

Mutations in zygotic polarity genes gsb-n and gsb do not interact with RpII140^wimp.

(Parkhurst and Ish-Horowicz, 1991)

wg expression is initiated normally in gsb-n and gsb embryos but by stage 11 the expression disappear from the ventral region whilst persisting in the dorsal region.

(Hidalgo and Ingham, 1990)

gsb-n and gsb have a specific role in the control of cell fates during neurogenesis. Mutants display a complex series of alterations in neuronal identity, both underneath and outside the modified ectoderm; posterior commissures are almost totally absent.

(Patel et al., 1989)

The gsb region is defined by the proximal breakpoint of Df(2R)Kr10 (map position 0 to +3.5) and by the distal breakpoint of Df(2R)gsb (map position +40 to +42.5).

(Cote et al., 1987)

Included in genetic and molecular analysis of the zipper-gooseberry region: no point mutations in gsb were obtained.

(Cote et al., 1987)

gsb-n and gsb are not autonomous at the level of the single cell.

(Wieschaus and Riggleman, 1987)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 39 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

38005

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P09082

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0001148

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0001148

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

gsb_1

Flygut - An atlas of the Drosophila adult midgut

FBgn0001148

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

38005

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG3388

modMine - A data warehouse for the modENCODE project

FBgn0001148

Linkouts

BioGRID - A database of protein and genetic interactions.

63573

DPiM - Drosophila Protein interaction map

FBgn0001148

DroID - A comprehensive database of gene and protein interactions.

FBgn0001148

DRSC - Results frm RNAi screens

FBgn0001148

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0001148

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG3388-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0001148

FlyMine - An integrated database for Drosophila genomics

FBgn0001148

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

38005

MIST (genetic) - An integrated Molecular Interaction Database

MIST (protein-protein) - An integrated Molecular Interaction Database

Synonyms and Secondary IDs (21)

Reported As

Symbol Synonym

BSH-9

(Barad et al., 1988)

BSH9

(Hoshiyama et al., 1998, Finkelstein and Perrimon, 1991, Bopp et al., 1989, Baumgartner et al., 1987)

BSH9c2

CG3388

(Shanshan and Laixin, 2015, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009, Klebes et al., 2005)

GSB-D

(Bassett et al., 1997)

Gsb

(Sarov et al., 2016, Li et al., 2015, Slattery et al., 2014)

Gsb-d

(Bossing and Brand, 2006, Schuldt, 2000)

gsb

(Sen et al., 2019, Rickert et al., 2018, Karaiskos et al., 2017, Transgenic RNAi Project members, 2017-, Bürglin and Affolter, 2016, Sarov et al., 2016, Sitnik et al., 2016, Urbach et al., 2016, Bivik et al., 2015, Gurdziel et al., 2015, Schertel et al., 2015, Ugrankar et al., 2015, He and Noll, 2013, McKay and Lieb, 2013, Saunders et al., 2013, Webber et al., 2013, Friedrich and Caravas, 2011, Kuzin et al., 2011, Marie et al., 2010, Gaziova and Bhat, 2009, Liu et al., 2009, Wheeler et al., 2009, Colomb et al., 2008, Baumgardt et al., 2007, Curtis et al., 2007, Magalhaes et al., 2007, Sandmann et al., 2007, Xing et al., 2007, Galindo et al., 2006, Oakley et al., 2006, Copley, 2005, Davis et al., 2005, Goldstein et al., 2005, Hoskins et al., 2005, Grad et al., 2004, Stanyon et al., 2004, Urbach and Technau, 2003)

gsb-2

(Andrew et al., 1997)

gsb-d

(Urbach et al., 2006, Urbach and Technau, 2004, Urbach and Technau, 2003, Urbach and Technau, 2003, Ashburner et al., 1999, Schuldt and Brand, 1999, Spradling et al., 1999, Chu et al., 1998, Dormand and Brand, 1998, Jones and Beckendorf, 1998, Srere, 1998, Balczarek et al., 1997, Dahl et al., 1997, He et al., 1997, McDonald and Doe, 1997, Agosti et al., 1996, Bhat, 1996, Copeland et al., 1996, Duman Scheel and Patel, 1996, Kaiser and Holmgren, 1996, Matsuzaki and Saigo, 1996, Miskiewicz et al., 1996, Broadus et al., 1995, Buenzow and Holmgren, 1995, Buenzow et al., 1995, Chu-LaGraff et al., 1995, McDonald et al., 1995, Meister and Braun, 1995.10, Skeath et al., 1995, BDGP Project Members, 1994-1999, Bouchard et al., 1994, Klingensmith and Nusse, 1994, Manak and Scott, 1994, Nusslein-Volhard, 1994, Patel, 1994, Perrimon, 1994, Zhang et al., 1994, Chu-LaGraff and Doe, 1993, Doe and Technau, 1993, Wilson et al., 1993, Zhang and Holmgren, 1993, Zhang et al., 1993, Grueneberg et al., 1992, Lindsley and Zimm, 1992, Skeath et al., 1992, Treisman et al., 1992, Hidalgo, 1991, Parkhurst and Ish-Horowicz, 1991, Ungar et al., 1991, Hidalgo and Ingham, 1990, McGinnis et al., 1990, Burri et al., 1989, Nakano et al., 1989, Patel et al., 1989, Cote et al., 1987, Wieschaus and Riggleman, 1987, Bopp et al., 1986, Nusslein-Volhard et al., 1984, Nusslein-Volhard and Wieschaus, 1980)

gsb-distal

(Ouellette et al., 1992)

gsbBSH9

(Matsuzaki et al., 1992)

gsbd

(Galliot et al., 1999)

l(2)01155

(Beaton, 1997.12.27, Perrimon et al., 1996)

l(2)gsb

(Perrimon and Mahowald, 1987)

Name Synonyms

Gooseberry

(Frank, 2014, Gaziova and Bhat, 2009, Beckervordersandforth et al., 2008, Colomb et al., 2008)

Gooseberry distal

(Bossing and Brand, 2006)

Gooseberry-Distal

(Tursun, 2012)

Gooseberry-distal

(McDonald et al., 2003)

gooseberry

(Urbach et al., 2016, Wieschaus and Nüsslein-Volhard, 2016, Li et al., 2014, He and Noll, 2013, McKay and Lieb, 2013, Friedrich and Caravas, 2011, Biehs et al., 2010, Marie et al., 2010, Ishihara and Shibata, 2008, Schwartz and Pirrotta, 2007, Xing et al., 2007, Galindo et al., 2006, Jones et al., 2006, Lucchetta et al., 2006, Goldstein et al., 2005, Pazdera et al., 1997, Bloom, 1996, Lipshitz et al., 1996)

gooseberry distal

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