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FB2025_02
,
released April 17, 2025
Please see the JBrowse view of Dmel\H2.0 for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.51
1.85 (northern blot)
There is only one protein coding transcript and one polypeptide associated with this gene
410 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\H2.0 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
H2.0 transcripts are expressed throughout development with the greatest abundance in 6-24hr embryos. They are first detected at stage 10 at the point of flexure where the invaginating posterior midgut primordium folds back against the extended germ band. In stage 11, H2.0 expression is found in a single layer of mesodermal cells nearest the yolk, along the entire length of the germ band from the posterior midgut to the anterior midgut invagination. This expression occurs in two bands that lie on either side of the midline. From late stage 11, H2.0 is expressed in all cells that are destined to form visceral musculature. Transcripts also begin to accumulate in ectodermal cells just anterior to the tracheal pits in each parasegment. At later stages, expression is limited to a thin sheet of visceral muscle cells enveloping the midgut, to a segmentally repeated structure of the ventro-lateral hypoderm and to a small patch of muscle in dorsal anterior T1.
JBrowse - Visual display of RNA-Seq signals
View Dmel\H2.0 in JBrowse
2-18
2-19.5
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
H2.0 is not essential for normal gut morphogenesis, visceral muscle actin organization or larval peristalsis.
H2.0 is not expressed in tin1 embryos.
Isolated from a genomic DNA library under low stringency using a genomic fragment containing the Scr homeobox as a probe.
H2.0 has been cloned and characterised. It is a homeobox gene which encodes a very diverged homeobox.
Encodes a novel, tissue-specific homeobox. A large deletion including H2.0 is homozygous lethal, but the lethality may not be due to the homeobox gene. Although the structure of most organs as well as the epidermis appears to be normal in these lethal embryos, the midgut forms a balloon like yolk-filled sac.
