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Gene Dmel\H2.0

General Information
Symbol	Dmel\H2.0	Species	D. melanogaster
Name	Homeodomain protein 2.0	Annotation symbol	CG11607
Feature type	protein_coding_gene	FlyBase ID	FBgn0001170
Gene Model Status	Current	Stock availability	3 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	26B2-26B3	Sequence location	2L:6,013,059..6,019,402 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Homeodomain protein 2.0 is referred to in FlyBase by the symbol Dmel\H2.0 (CG11607, FBgn0001170). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: sequence-specific DNA binding transcription factor activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: regulation of transcription, DNA-dependent. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Homeobox, conserved site; Homeodomain; Homeodomain, metazoa; Homeodomain-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 06-24 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1633895_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of H2.0. Gene sequence location is 2L:6013057..6019398.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	H2.0: Homeobox 2.0 Encodes a novel, tissue-specific homeobox. A large deletion including H2.0 is homozygous lethal, but the lethality may not be due to the homeobox gene. Although the structure of most organs as well as the epidermis appears to be normal in these lethal embryos, the midgut forms a balloon like yolk-filled sac.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 26B2-26B3   Limits computationally determined from genome sequence between P{EP}chicEP713&P{EP}chicEP1095 and P{lacW}Gef26k13720
Experimentally Determined Cytological Location
Cytogenetic map Notes References 26B1-26B3   (determined by in situ hybridisation)   (Barad et al., 1988)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\H2.0 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.51
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) H2.0-RA FBtr0079227  NM_078764   1662   418
Additional Transcript Data & Comments
Reported size (kB)	1.85 (northern blot) (Barad et al., 1988)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein H2.0-PA   FBpp0078858   45.8   418   8.36     NP_523488   AAF52323
Additional Polypeptide Data & Comments
Reported size (kDa)	410 (aa) (Barad et al., 1988)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Homeobox, conserved site (IPR017970) Homeodomain (IPR001356) Homeodomain-like (IPR009057) Homeodomain, metazoa (IPR020479)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF52323   AY119136 AAM50996   BI240824   BT025227   GH738835   GH740278   GH741393   GH742153   GH767346   GH834750   GH836710   GH888919   Y00843 CAA68766
UniProtKB/Swiss-Prot	P10035
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11 -- 12   circular visceral muscle primordium   (Fisher et al., 2012) dorsal epidermis primordium   (Fisher et al., 2012) visceral muscle primordium   (Fisher et al., 2012) embryonic stage 11 -- 17   visceral mesoderm   (Bodmer et al., 1990) embryonic stage 13 -- 16   embryonic dorsal epidermis   (Fisher et al., 2012) embryonic ventral epidermis   (Fisher et al., 2012) embryonic/larval visceral muscle   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Barad et al., 1988) embryonic stage 11 -- 17   visceral mesoderm of embryonic/larval midgut   (Barad et al., 1988) embryonic stage 12 -- 17   ectoderm   (Barad et al., 1988)
Additional Descriptive Data
	H2.0 is primarily expressed in the visceral primordia of the mesoderm and the expression persists throughout visceral development. H2.0 transcripts are located at approximately the same position and depth in the embryo as tin transcripts. (Bodmer et al., 1990) H2.0 transcripts are expressed throughout development with the greatest abundance in 6-24hr embryos. They are first detected at stage 10 at the point of flexure where the invaginating posterior midgut primordium folds back against the extended germ band. In stage 11, H2.0 expression is found in a single layer of mesodermal cells nearest the yolk, along the entire length of the germ band from the posterior midgut to the anterior midgut invagination. This expression occurs in two bands that lie on either side of the midline. From late stage 11, H2.0 is expressed in all cells that are destined to form visceral musculature. Transcripts also begin to accumulate in ectodermal cells just anterior to the tracheal pits in each parasegment. At later stages, expression is limited to a thin sheet of visceral muscle cells enveloping the midgut, to a segmentally repeated structure of the ventro-lateral hypoderm and to a small patch of muscle in dorsal anterior T1. (Barad et al., 1988)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1.825 Larval Midgut    25.9 Larval Hindgut    3.2 Larval Malpighian Tubules    2.8 Larval Fat Body    5.5 Larval Salivary Gland    2.5 Larval Trachea    2.9 Larval Carcass    7.3 Adult Head    3.6 Adult Eye    1.1 Adult Brain    0.9 Adult Thoracic-Abdominal Ganglion    1.3 Adult Crop    2.9 Adult Midgut    33 Adult Hindgut    4.5 Adult Malpighian Tubules    2.2 Adult Fat Body    2.8 Adult Salivary Gland    10.7 Adult Heart    1.65 Adult VirginFemale Spermatheca    4.5 Adult InseminatedFemale Spermatheca    5.1 Adult Ovary    1.5 Adult Testis    9.2 Adult Male Accessory Gland    1.4 Adult Carcass    2.5 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    1.825 Larval Midgut    25.9 Larval Hindgut    3.2 Larval Malpighian Tubules    2.8 Larval Fat Body    5.5 Larval Salivary Gland    2.5 Larval Trachea    2.9 Larval Carcass    7.3 Adult Head    3.6 Adult Eye    1.1 Adult Brain    0.9 Adult Thoracic-Abdominal Ganglion    1.3 Adult Crop    2.9 Adult Midgut    33 Adult Hindgut    4.5 Adult Malpighian Tubules    2.2 Adult Fat Body    2.8 Adult Salivary Gland    10.7 Adult Heart    1.65 Adult VirginFemale Spermatheca    4.5 Adult InseminatedFemale Spermatheca    5.1 Adult Ovary    1.5 Adult Testis    9.2 Adult Male Accessory Gland    1.4 Adult Carcass    2.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    1.825 Larval Midgut    25.9 Larval Hindgut    3.2 Larval Malpighian Tubules    2.8 Larval Fat Body    5.5 Larval Salivary Gland    2.5 Larval Trachea    2.9 Larval Carcass    7.3 Adult Head    3.6 Adult Eye    1.1 Adult Brain    0.9 Adult Thoracic-Abdominal Ganglion    1.3 Adult Crop    2.9 Adult Midgut    33 Adult Hindgut    4.5 Adult Malpighian Tubules    2.2 Adult Fat Body    2.8 Adult Salivary Gland    10.7 Adult Heart    1.65 Adult VirginFemale Spermatheca    4.5 Adult InseminatedFemale Spermatheca    5.1 Adult Ovary    1.5 Adult Testis    9.2 Adult Male Accessory Gland    1.4 Adult Carcass    2.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1.825 Larval Midgut    25.9 Larval Hindgut    3.2 Larval Malpighian Tubules    2.8 Larval Fat Body    5.5 Larval Salivary Gland    2.5 Larval Trachea    2.9 Larval Carcass    7.3 Adult Head    3.6 Adult Eye    1.1 Adult Brain    0.9 Adult Thoracic-Abdominal Ganglion    1.3 Adult Crop    2.9 Adult Midgut    33 Adult Hindgut    4.5 Adult Malpighian Tubules    2.2 Adult Fat Body    2.8 Adult Salivary Gland    10.7 Adult Heart    1.65 Adult VirginFemale Spermatheca    4.5 Adult InseminatedFemale Spermatheca    5.1 Adult Ovary    1.5 Adult Testis    9.2 Adult Male Accessory Gland    1.4 Adult Carcass    2.5 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1.825 Larval Midgut    25.9 Larval Hindgut    3.2 Larval Malpighian Tubules    2.8 Larval Fat Body    5.5 Larval Salivary Gland    2.5 Larval Trachea    2.9 Larval Carcass    7.3 Adult Head    3.6 Adult Eye    1.1 Adult Brain    0.9 Adult Thoracic-Abdominal Ganglion    1.3 Adult Crop    2.9 Adult Midgut    33 Adult Hindgut    4.5 Adult Malpighian Tubules    2.2 Adult Fat Body    2.8 Adult Salivary Gland    10.7 Adult Heart    1.65 Adult VirginFemale Spermatheca    4.5 Adult InseminatedFemale Spermatheca    5.1 Adult Ovary    1.5 Adult Testis    9.2 Adult Male Accessory Gland    1.4 Adult Carcass    2.5 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    1.825 Larval Midgut    25.9 Larval Hindgut    3.2 Larval Malpighian Tubules    2.8 Larval Fat Body    5.5 Larval Salivary Gland    2.5 Larval Trachea    2.9 Larval Carcass    7.3 Adult Head    3.6 Adult Eye    1.1 Adult Brain    0.9 Adult Thoracic-Abdominal Ganglion    1.3 Adult Crop    2.9 Adult Midgut    33 Adult Hindgut    4.5 Adult Malpighian Tubules    2.2 Adult Fat Body    2.8 Adult Salivary Gland    10.7 Adult Heart    1.65 Adult VirginFemale Spermatheca    4.5 Adult InseminatedFemale Spermatheca    5.1 Adult Ovary    1.5 Adult Testis    9.2 Adult Male Accessory Gland    1.4 Adult Carcass    2.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    1.825 Larval Midgut    25.9 Larval Hindgut    3.2 Larval Malpighian Tubules    2.8 Larval Fat Body    5.5 Larval Salivary Gland    2.5 Larval Trachea    2.9 Larval Carcass    7.3 Adult Head    3.6 Adult Eye    1.1 Adult Brain    0.9 Adult Thoracic-Abdominal Ganglion    1.3 Adult Crop    2.9 Adult Midgut    33 Adult Hindgut    4.5 Adult Malpighian Tubules    2.2 Adult Fat Body    2.8 Adult Salivary Gland    10.7 Adult Heart    1.65 Adult VirginFemale Spermatheca    4.5 Adult InseminatedFemale Spermatheca    5.1 Adult Ovary    1.5 Adult Testis    9.2 Adult Male Accessory Gland    1.4 Adult Carcass    2.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1.825 Larval Midgut    25.9 Larval Hindgut    3.2 Larval Malpighian Tubules    2.8 Larval Fat Body    5.5 Larval Salivary Gland    2.5 Larval Trachea    2.9 Larval Carcass    7.3 Adult Head    3.6 Adult Eye    1.1 Adult Brain    0.9 Adult Thoracic-Abdominal Ganglion    1.3 Adult Crop    2.9 Adult Midgut    33 Adult Hindgut    4.5 Adult Malpighian Tubules    2.2 Adult Fat Body    2.8 Adult Salivary Gland    10.7 Adult Heart    1.65 Adult VirginFemale Spermatheca    4.5 Adult InseminatedFemale Spermatheca    5.1 Adult Ovary    1.5 Adult Testis    9.2 Adult Male Accessory Gland    1.4 Adult Carcass    2.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    3.6   NA  Eye    1.1   NA  Brain    0.9   1.825  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1.3   NA  Crop    2.9   no informative data  Midgut    no informative data   3.2  Hindgut    4.5   2.8  Malpighian Tubules    2.2   5.5  Fat Body    2.8   2.5  Salivary Gland    no informative data   NA  Heart    1.65   2.9  Trachea    NA   NA  VirginFemale Spermatheca    4.5   NA  InseminatedFemale Spermatheca    5.1   NA  Ovary    1.5   NA  Testis    9.2   NA  Male Accessory Gland    1.4   7.3  Carcass    2.5 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    1 head, mated 20-day female    0 head, mated 1-day male    2 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    1 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    2 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    1 head, mated 20-day female    0 head, mated 1-day male    2 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    1 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    2 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    1 head, mated 20-day female    0 head, mated 1-day male    2 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    1 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    2 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    1 head, mated 20-day female    0 head, mated 1-day male    2 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    1 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    2 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    1 head, mated 20-day female    0 head, mated 1-day male    2 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    1 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    2 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    1 head, mated 20-day female    0 head, mated 1-day male    2 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    1 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    2 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    1 head, mated 20-day female    0 head, mated 1-day male    2 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    1 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    2 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    2 central nervous system, larvae L3    0 central nervous system, pupae P8    0 head, virgin 1-day female    1 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    1 head, mated 20-day female    0 head, mated 1-day male    2 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    1 digestive system, 4-day adult    3 digestive system, 20-day adult    2 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    2 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderate expression to a trough of extremely low expression. Peak expression observed within 06-24 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    4 embryo 08-10hr    6 embryo 10-12hr    11 embryo 12-14hr    9 embryo 14-16hr    7 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    3 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    1 adult male 01day    0 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    4 embryo 08-10hr    6 embryo 10-12hr    11 embryo 12-14hr    9 embryo 14-16hr    7 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    3 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    1 adult male 01day    0 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    4 embryo 08-10hr    6 embryo 10-12hr    11 embryo 12-14hr    9 embryo 14-16hr    7 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    3 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    1 adult male 01day    0 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    4 embryo 08-10hr    6 embryo 10-12hr    11 embryo 12-14hr    9 embryo 14-16hr    7 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    3 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    1 adult male 01day    0 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    4 embryo 08-10hr    6 embryo 10-12hr    11 embryo 12-14hr    9 embryo 14-16hr    7 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    3 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    1 adult male 01day    0 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    4 embryo 08-10hr    6 embryo 10-12hr    11 embryo 12-14hr    9 embryo 14-16hr    7 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    3 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    1 adult male 01day    0 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    4 embryo 08-10hr    6 embryo 10-12hr    11 embryo 12-14hr    9 embryo 14-16hr    7 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    3 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    1 adult male 01day    0 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    4 embryo 08-10hr    6 embryo 10-12hr    11 embryo 12-14hr    9 embryo 14-16hr    7 embryo 16-18hr    4 embryo 18-20hr    5 embryo 20-22hr    5 embryo 22-24hr    6 larva L1    3 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    1 pupae 3d postWPP    0 pupae 4d postWPP    1 adult male 01day    0 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    1 cold shock, 4-day adult    1 heat shock, 4-day adult    0 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    0 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    1 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    0 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    1 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_11
External Data & Images
Linkouts	BDGP expression data • CG11607 RE37758 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001170 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11607-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for H2.0 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage, with Scer\GAL4pnr-MD237 H2.0GD4057 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of H2.0 Class Mutagen Stocks Known lesion H2.0MB06569 1 --
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of H2.0 Class Mutagen Stocks Known lesion H2.0GD4057 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)AP1 (Barad et al., 1991) Df(2L)Exel8017 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4057} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}H2.0MB06569 No
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
sequence-specific DNA binding inferred from electronic annotation with InterPro:IPR001356, InterPro:IPR017970 (FlyBase Curators et al., 2004-) sequence-specific DNA binding transcription factor activity inferred from sequence or structural similarity with UniProtKB:Q14774 (FlyBase, 1992-)
Biological Process
CV term Evidence References
regulation of transcription, DNA-dependent inferred from electronic annotation with InterPro:IPR001356, InterPro:IPR012287, InterPro:IPR017970 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity with UniProtKB:Q14774 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1989.3.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
H2.0 - CG6617 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) H2.0 - Gp210 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) H2.0 - Hsc70-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) H2.0 - Rpb8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) H2.0 - mRpS24 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions H2.0 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60006 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0001170 DroID - A comprehensive database of gene and protein interactions. • FBgn0001170 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33841
Orthologs
OrthoDB Orthologs (36) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6G7CJR Dipteran inclusive ortholog search EOG6N04Q6 Insect inclusive ortholog search EOG6KWHPZ Arthropod inclusive ortholog search EOG6C868J Metazoa inclusive ortholog search EOG6H4JZN
Orthologs in Drosophila Species (EOG6G7CJR)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\H2.0     Drosophila simulans   Dsim\GD22610 Y   Drosophila sechellia   Dsec\GM17974 Y   Drosophila erecta   Dere\GG10151 Y   Drosophila yakuba   Dyak\GE18959 Y   Drosophila ananassae   Dana\GF14286 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA11095 Y   Drosophila persimilis   Dper\GL19089 Y   Drosophila willistoni   Dwil\GK15402 Y   Drosophila virilis   Dvir\GJ12503 Y   Drosophila mojavensis   Dmoj\GI11292 Y   Drosophila grimshawi   Dgri\GH10711 Y
Orthologs in non-Drosophila Dipterans (EOG6N04Q6)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL005974 Y Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012150 Y Anopheles gambiae Malaria mosquito  Agam\AGAP005727 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ015450 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ016099 Y
Orthologs in non-Dipteran Insects (EOG6KWHPZ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC725302   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG012793   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH25837   Atta cephalotes Leafcutter ant  Acep\ACEP14997   Camponotus floridanus Florida carpenter ant  Cflo\CFLO15593   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL21191   Linepithema humile Argentine ant  Lhum\LH20205   Pogonomyrmex barbatus Red harvester ant  Pbar\PB23680   Solenopsis invicta Red fire ant  Sinv\SINV11867   Acyrthosiphon pisum Pea aphid  Apim\ACYPI48371   Bombyx mori Silkmoth  Bmor\BGIBMGA008482   Pediculus humanus Human body louse  Phum\PHUM604510   Tribolium castaneum Red flour beetle  Tcas\GLEAN_08368
Orthologs in non-Insect Arthropods (EOG6C868J)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\TAS2R7
Orthologs in non-Arthropod Metazoa (EOG6H4JZN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_014802gn   Danio rerio Zebrafish  Drer\hlx1   Xenopus tropicalis Western clawed frog  Xtro\hlx   Rattus norvegicus Norway rat  Rnor\Hlx   Homo sapiens Human  Hsap\HLX
Human Orthologs (1)
Gene OMIM HGNC Hsap\HLX
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD22610 Drosophila sechellia Dsec\GM17974 Drosophila erecta Dere\GG10151 Drosophila yakuba Dyak\GE18959 Drosophila ananassae Dana\GF14286 Drosophila pseudoobscura pseudoobscura Dpse\GA11095 Drosophila persimilis Dper\GL19089 Drosophila willistoni Dwil\GK15402 Drosophila virilis Dvir\GJ12503 Drosophila mojavensis Dmoj\GI11292 Drosophila grimshawi Dgri\GH10711
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	25626 w1118; Mi{ET1}H2.0MB06569
VDRC	v15876 w1118; P{GD4057}v15876 v15875 w1118; P{GD4057}v15875/TM3
Genomic Clones ( 1 )
	BACR10M11 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 11 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE37758
Other clones	DPiM_FI01011 FI01011
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	RP01476 RP001006286 RP001019044 RP001021546 RP001031823 RP003449480 RP003477292 RP003550405
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0001170 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33841
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	H2.0 is not essential for normal gut morphogenesis, visceral muscle actin organization or larval peristalsis. (Barad et al., 1991) H2.0 is not expressed in tin1 embryos. (Bodmer et al., 1991) Isolated from a genomic DNA library under low stringency using a genomic fragment containing the Scr homeobox as a probe. (Barad et al., 1988) H2.0 has been cloned and characterised. It is a homeobox gene which encodes a very diverged homeobox. (Barad et al., 1988) Encodes a novel, tissue-specific homeobox. A large deletion including H2.0 is homozygous lethal, but the lethality may not be due to the homeobox gene. Although the structure of most organs as well as the epidermis appears to be normal in these lethal embryos, the midgut forms a balloon like yolk-filled sac.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078764 RefSeq (Proteins) • NP_523488 DDBJ / EMBL / GenBank • AAF52323 AAM50996 AY119136 BI240824 CAA68766 Y00843 Entrez Gene - A searchable database of RefSeq genes. • 33841 UniProtKB/Swiss-Prot • P10035
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Homeobox, conserved site (IPR017970) Homeodomain (IPR001356) Homeodomain-like (IPR009057) Homeodomain, metazoa (IPR020479) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • CG11607 RE37758
Linkouts
	BioGRID - A database of protein and genetic interactions • 60006 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0001170 DroID - A comprehensive database of gene and protein interactions. • FBgn0001170 DRSC - Results from RNAi screens. • FBgn0001170 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001170 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG11607-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0001170 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33841 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33841 modMine - Data generated by the modENCODE project. • FBgn0001170
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	CG11607   H2.0 (Copley, 2005, Lacin et al., 2009, Nfonsam et al., 2012)
Name Synonym	Homeodomain protein 2.0
Secondary FlyBase IDs
References ( 30 )
Generate a list of	All references relating to this gene ( 30 )
List References by type	Research paper  ( 11 ) Supplementary material  ( 3 ) Review  ( 1 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 1 ) FlyBase analysis  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 ) Book  ( 1 )
Recent research papers ( 1 )
	Nfonsam et al., 2012, PLoS ONE 7(8): e44583 Analysis of the Transcriptomes Downstream of Eyeless and the Hedgehog, Decapentaplegic and Notch Signaling Pathways in Drosophila melanogaster. [FBrf0219414] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...