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Gene Dmel\hfw

General Information
Symbol	Dmel\hfw	Species	D. melanogaster
Name	halfway	Annotation symbol	CG3095
Feature type	protein_coding_gene	FlyBase ID	FBgn0001189
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	swi, EG:171E4.2
Genomic Location
Chromosome (arm)	X	Recombination map	1-0.4
Cytogenetic map	2B5-2B6	Sequence location	X:1,563,626..1,567,143 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene halfway is referred to in FlyBase by the symbol Dmel\hfw (CG3095, FBgn0001189). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: intracellular signal transduction; response to ecdysone; pupariation. 15 alleles are reported. The phenotypes of these alleles are annotated with: adult abdomen; wing. It has one annotated transcript and one annotated polypeptide. Protein features are: Leucine-rich repeat. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1634614_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of hfw. Gene sequence location is X:1563626..1567143.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	hfw: halfway Recessive lethal; for some alleles, development arrested in third instar, the anterior half initiating puparium formation while the posterior half remains larval. Extent of development influenced by administration of ecdysone and by temperature; pupariation occasionally completed at 18. Some alleles yield a few survivors with characteristic wing abnormalities and occasionally swollen abdomens.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features HFA18506 BKN25374
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 2B5-2B6   Limits computationally determined from genome sequence between P{EP}brEP1515 and P{EP}EP1444&P{EP}CG14818EP1190
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	1-0.4 (Aizenzon and Belyaeva, 1982)
Left of (cM)	l(1)2Bh (Aizenzon and Belyaeva, 1982)
Right of (cM)	br dor (Aizenzon and Belyaeva, 1982)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\hfw for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.39
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) hfw-RA FBtr0070270  NM_130577   2517   611
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein hfw-PA   FBpp0070260   68.5   611   6.43     NP_569933   AAF45654
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Leucine-rich repeat (IPR001611)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF45654   AJ626646 CAF25166   AL021726 CAA16810   AY070931 AAL48553   BG633283   BI163705   BI357974   BT050442   BT126076   CA804113   CO272462   CO273171   CO323714   CO331597   CO331603   EC067701   EC197464   EC197891   EC235179   EC239662   EC254965   EL870374
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9W568
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0001189    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0001189 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0001189 expression level Developmental Stage   Expression Level embryo 00-02hr    1427 embryo 02-04hr    1433 embryo 04-06hr    1852 embryo 06-08hr    1967 embryo 08-10hr    2104 embryo 10-12hr    2126 embryo 12-14hr    2148 embryo 14-16hr    1902 embryo 16-18hr    1534 embryo 18-20hr    1258 embryo 20-22hr    780 embryo 22-24hr    831 larva L1    1094 larva L2    1030 larva L3 12hr old    1058 larva L3 puffstage 1-2    1805 larva L3 puffstage 3-6    1971 larva L3 puffstage 7-9    2174 white prepupae new    2247 white prepupae 12hr    2515 white prepupae 24hr    2938 pupae 2d postWPP    2162 pupae 3d postWPP    1322 pupae 4d postWPP    1237 adult male 01day    1529 adult male 05day    1483 adult male 30day    1724 adult female 01day    1758 adult female 05day    1304 adult female 30day    1325 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1427) embryo 02-04hr  (1433) embryo 04-06hr  (1852) embryo 06-08hr  (1967) embryo 08-10hr  (2104) embryo 10-12hr  (2126) embryo 12-14hr  (2148) embryo 14-16hr  (1902) embryo 16-18hr  (1534) embryo 18-20hr  (1258) embryo 20-22hr  (780) embryo 22-24hr  (831) larva L1  (1094) larva L2  (1030) larva L3 12hr old  (1058) larva L3 puffstage 1-2  (1805) larva L3 puffstage 3-6  (1971) larva L3 puffstage 7-9  (2174) white prepupae new  (2247) white prepupae 12hr  (2515) white prepupae 24hr  (2938) pupae 2d postWPP  (2162) pupae 3d postWPP  (1322) pupae 4d postWPP  (1237) adult male 01day  (1529) adult male 05day  (1483) adult male 30day  (1724) adult female 01day  (1758) adult female 05day  (1304) adult female 30day  (1325) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1427 embryo 02-04hr  1433 embryo 04-06hr  (1852) embryo 06-08hr  (1967) embryo 08-10hr  (2104) embryo 10-12hr  (2126) embryo 12-14hr  (2148) embryo 14-16hr  (1902) embryo 16-18hr  (1534) embryo 18-20hr    1258 embryo 20-22hr    780 embryo 22-24hr    831 larva L1    1094 larva L2    1030 larva L3 12hr old    1058 larva L3 puffstage 1-2  (1805) larva L3 puffstage 3-6  (1971) larva L3 puffstage 7-9  (2174) white prepupae new  (2247) white prepupae 12hr  (2515) white prepupae 24hr  (2938) pupae 2d postWPP  (2162) pupae 3d postWPP    1322 pupae 4d postWPP    1237 adult male 01day  (1529) adult male 05day  1483 adult male 30day  (1724) adult female 01day  (1758) adult female 05day    1304 adult female 30day    1325 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1427 embryo 02-04hr    1433 embryo 04-06hr    1852 embryo 06-08hr    1967 embryo 08-10hr    2104 embryo 10-12hr    2126 embryo 12-14hr    2148 embryo 14-16hr    1902 embryo 16-18hr    1534 embryo 18-20hr    1258 embryo 20-22hr    780 embryo 22-24hr    831 larva L1    1094 larva L2    1030 larva L3 12hr old    1058 larva L3 puffstage 1-2    1805 larva L3 puffstage 3-6    1971 larva L3 puffstage 7-9    2174 white prepupae new    2247 white prepupae 12hr    2515 white prepupae 24hr    2938 pupae 2d postWPP    2162 pupae 3d postWPP    1322 pupae 4d postWPP    1237 adult male 01day    1529 adult male 05day    1483 adult male 30day    1724 adult female 01day    1758 adult female 05day    1304 adult female 30day    1325 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1427 embryo 02-04hr    1433 embryo 04-06hr    1852 embryo 06-08hr    1967 embryo 08-10hr    2104 embryo 10-12hr    2126 embryo 12-14hr    2148 embryo 14-16hr    1902 embryo 16-18hr    1534 embryo 18-20hr    1258 embryo 20-22hr    780 embryo 22-24hr    831 larva L1    1094 larva L2    1030 larva L3 12hr old    1058 larva L3 puffstage 1-2    1805 larva L3 puffstage 3-6    1971 larva L3 puffstage 7-9    2174 white prepupae new    2247 white prepupae 12hr    2515 white prepupae 24hr    2938 pupae 2d postWPP    2162 pupae 3d postWPP    1322 pupae 4d postWPP    1237 adult male 01day    1529 adult male 05day    1483 adult male 30day    1724 adult female 01day    1758 adult female 05day    1304 adult female 30day    1325 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0001189 expression level Developmental Stage   Expression Level embryo 00-02hr    1427 embryo 02-04hr    1433 embryo 04-06hr    1852 embryo 06-08hr    1967 embryo 08-10hr    2104 embryo 10-12hr    2126 embryo 12-14hr    2148 embryo 14-16hr    1902 embryo 16-18hr    1534 embryo 18-20hr    1258 embryo 20-22hr    780 embryo 22-24hr    831 larva L1    1094 larva L2    1030 larva L3 12hr old    1058 larva L3 puffstage 1-2    1805 larva L3 puffstage 3-6    1971 larva L3 puffstage 7-9    2174 white prepupae new    2247 white prepupae 12hr    2515 white prepupae 24hr    2938 pupae 2d postWPP    2162 pupae 3d postWPP    1322 pupae 4d postWPP    1237 adult male 01day    1529 adult male 05day    1483 adult male 30day    1724 adult female 01day    1758 adult female 05day    1304 adult female 30day    1325 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1427) embryo 02-04hr  (1433) embryo 04-06hr  (1852) embryo 06-08hr  (1967) embryo 08-10hr  (2104) embryo 10-12hr  (2126) embryo 12-14hr  (2148) embryo 14-16hr  (1902) embryo 16-18hr  (1534) embryo 18-20hr  (1258) embryo 20-22hr  (780) embryo 22-24hr  (831) larva L1  (1094) larva L2  (1030) larva L3 12hr old  (1058) larva L3 puffstage 1-2  (1805) larva L3 puffstage 3-6  (1971) larva L3 puffstage 7-9  (2174) white prepupae new  (2247) white prepupae 12hr  (2515) white prepupae 24hr  (2938) pupae 2d postWPP  (2162) pupae 3d postWPP  (1322) pupae 4d postWPP  (1237) adult male 01day  (1529) adult male 05day  (1483) adult male 30day  (1724) adult female 01day  (1758) adult female 05day  (1304) adult female 30day  (1325) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1427 embryo 02-04hr  1433 embryo 04-06hr  1852 embryo 06-08hr  1967 embryo 08-10hr  2104 embryo 10-12hr  2126 embryo 12-14hr  2148 embryo 14-16hr  1902 embryo 16-18hr  1534 embryo 18-20hr    1258 embryo 20-22hr    780 embryo 22-24hr    831 larva L1    1094 larva L2    1030 larva L3 12hr old    1058 larva L3 puffstage 1-2  1805 larva L3 puffstage 3-6  1971 larva L3 puffstage 7-9  2174 white prepupae new  2247 white prepupae 12hr  (2515) white prepupae 24hr  (2938) pupae 2d postWPP  2162 pupae 3d postWPP    1322 pupae 4d postWPP    1237 adult male 01day  1529 adult male 05day  1483 adult male 30day  1724 adult female 01day  1758 adult female 05day    1304 adult female 30day    1325 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1427 embryo 02-04hr    1433 embryo 04-06hr    1852 embryo 06-08hr    1967 embryo 08-10hr    2104 embryo 10-12hr    2126 embryo 12-14hr    2148 embryo 14-16hr    1902 embryo 16-18hr    1534 embryo 18-20hr    1258 embryo 20-22hr    780 embryo 22-24hr    831 larva L1    1094 larva L2    1030 larva L3 12hr old    1058 larva L3 puffstage 1-2    1805 larva L3 puffstage 3-6    1971 larva L3 puffstage 7-9    2174 white prepupae new    2247 white prepupae 12hr    2515 white prepupae 24hr    2938 pupae 2d postWPP    2162 pupae 3d postWPP    1322 pupae 4d postWPP    1237 adult male 01day    1529 adult male 05day    1483 adult male 30day    1724 adult female 01day    1758 adult female 05day    1304 adult female 30day    1325 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1427 embryo 02-04hr    1433 embryo 04-06hr    1852 embryo 06-08hr    1967 embryo 08-10hr    2104 embryo 10-12hr    2126 embryo 12-14hr    2148 embryo 14-16hr    1902 embryo 16-18hr    1534 embryo 18-20hr    1258 embryo 20-22hr    780 embryo 22-24hr    831 larva L1    1094 larva L2    1030 larva L3 12hr old    1058 larva L3 puffstage 1-2    1805 larva L3 puffstage 3-6    1971 larva L3 puffstage 7-9    2174 white prepupae new    2247 white prepupae 12hr    2515 white prepupae 24hr    2938 pupae 2d postWPP    2162 pupae 3d postWPP    1322 pupae 4d postWPP    1237 adult male 01day    1529 adult male 05day    1483 adult male 30day    1724 adult female 01day    1758 adult female 05day    1304 adult female 30day    1325 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0001189    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0001189 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0001189 expression level Tissue   Expression Level Larval Central Nervous System    83.15 Larval Midgut    274.6 Larval Hindgut    251.7 Larval Malpighian Tubules    161.9 Larval Fat Body    191.6 Larval Salivary Gland    159.8 Larval Trachea    157.125 Larval Carcass    117.125 Adult Head    100.9 Adult Eye    98.45 Adult Brain    46 Adult Thoracic-Abdominal Ganglion    74.6 Adult Crop    205.2 Adult Midgut    219.1 Adult Hindgut    127.9 Adult Malpighian Tubules    169 Adult Fat Body    187.1 Adult Salivary Gland    256.8 Adult Heart    116.75 Adult VirginFemale Spermatheca    266.1 Adult InseminatedFemale Spermatheca    272.6 Adult Ovary    114 Adult Testis    47.4 Adult Male Accessory Gland    408.2 Adult Carcass    148.9 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    83.15 Larval Midgut    274.6 Larval Hindgut    251.7 Larval Malpighian Tubules    161.9 Larval Fat Body    191.6 Larval Salivary Gland    159.8 Larval Trachea    157.125 Larval Carcass    117.125 Adult Head    100.9 Adult Eye    98.45 Adult Brain    46 Adult Thoracic-Abdominal Ganglion    74.6 Adult Crop    205.2 Adult Midgut    219.1 Adult Hindgut    127.9 Adult Malpighian Tubules    169 Adult Fat Body    187.1 Adult Salivary Gland    256.8 Adult Heart    116.75 Adult VirginFemale Spermatheca    266.1 Adult InseminatedFemale Spermatheca    272.6 Adult Ovary    114 Adult Testis    47.4 Adult Male Accessory Gland    408.2 Adult Carcass    148.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    83.15 Larval Midgut    274.6 Larval Hindgut    251.7 Larval Malpighian Tubules    161.9 Larval Fat Body    191.6 Larval Salivary Gland    159.8 Larval Trachea    157.125 Larval Carcass    117.125 Adult Head    100.9 Adult Eye    98.45 Adult Brain    46 Adult Thoracic-Abdominal Ganglion    74.6 Adult Crop    205.2 Adult Midgut    219.1 Adult Hindgut    127.9 Adult Malpighian Tubules    169 Adult Fat Body    187.1 Adult Salivary Gland    256.8 Adult Heart    116.75 Adult VirginFemale Spermatheca    266.1 Adult InseminatedFemale Spermatheca    272.6 Adult Ovary    114 Adult Testis    47.4 Adult Male Accessory Gland    408.2 Adult Carcass    148.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    83.15 Larval Midgut    274.6 Larval Hindgut    251.7 Larval Malpighian Tubules    161.9 Larval Fat Body    191.6 Larval Salivary Gland    159.8 Larval Trachea    157.125 Larval Carcass    117.125 Adult Head    100.9 Adult Eye    98.45 Adult Brain    46 Adult Thoracic-Abdominal Ganglion    74.6 Adult Crop    205.2 Adult Midgut    219.1 Adult Hindgut    127.9 Adult Malpighian Tubules    169 Adult Fat Body    187.1 Adult Salivary Gland    256.8 Adult Heart    116.75 Adult VirginFemale Spermatheca    266.1 Adult InseminatedFemale Spermatheca    272.6 Adult Ovary    114 Adult Testis    47.4 Adult Male Accessory Gland    408.2 Adult Carcass    148.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0001189 expression level Tissue   Expression Level Larval Central Nervous System    83.15 Larval Midgut    274.6 Larval Hindgut    251.7 Larval Malpighian Tubules    161.9 Larval Fat Body    191.6 Larval Salivary Gland    159.8 Larval Trachea    157.125 Larval Carcass    117.125 Adult Head    100.9 Adult Eye    98.45 Adult Brain    46 Adult Thoracic-Abdominal Ganglion    74.6 Adult Crop    205.2 Adult Midgut    219.1 Adult Hindgut    127.9 Adult Malpighian Tubules    169 Adult Fat Body    187.1 Adult Salivary Gland    256.8 Adult Heart    116.75 Adult VirginFemale Spermatheca    266.1 Adult InseminatedFemale Spermatheca    272.6 Adult Ovary    114 Adult Testis    47.4 Adult Male Accessory Gland    408.2 Adult Carcass    148.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    83.15 Larval Midgut    274.6 Larval Hindgut    251.7 Larval Malpighian Tubules    161.9 Larval Fat Body    191.6 Larval Salivary Gland    159.8 Larval Trachea    157.125 Larval Carcass    117.125 Adult Head    100.9 Adult Eye    98.45 Adult Brain    46 Adult Thoracic-Abdominal Ganglion    74.6 Adult Crop    205.2 Adult Midgut    219.1 Adult Hindgut    127.9 Adult Malpighian Tubules    169 Adult Fat Body    187.1 Adult Salivary Gland    256.8 Adult Heart    116.75 Adult VirginFemale Spermatheca    266.1 Adult InseminatedFemale Spermatheca    272.6 Adult Ovary    114 Adult Testis    47.4 Adult Male Accessory Gland    408.2 Adult Carcass    148.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    83.15 Larval Midgut    274.6 Larval Hindgut    251.7 Larval Malpighian Tubules    161.9 Larval Fat Body    191.6 Larval Salivary Gland    159.8 Larval Trachea    157.125 Larval Carcass    117.125 Adult Head    100.9 Adult Eye    98.45 Adult Brain    46 Adult Thoracic-Abdominal Ganglion    74.6 Adult Crop    205.2 Adult Midgut    219.1 Adult Hindgut    127.9 Adult Malpighian Tubules    169 Adult Fat Body    187.1 Adult Salivary Gland    256.8 Adult Heart    116.75 Adult VirginFemale Spermatheca    266.1 Adult InseminatedFemale Spermatheca    272.6 Adult Ovary    114 Adult Testis    47.4 Adult Male Accessory Gland    408.2 Adult Carcass    148.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    83.15 Larval Midgut    274.6 Larval Hindgut    251.7 Larval Malpighian Tubules    161.9 Larval Fat Body    191.6 Larval Salivary Gland    159.8 Larval Trachea    157.125 Larval Carcass    117.125 Adult Head    100.9 Adult Eye    98.45 Adult Brain    46 Adult Thoracic-Abdominal Ganglion    74.6 Adult Crop    205.2 Adult Midgut    219.1 Adult Hindgut    127.9 Adult Malpighian Tubules    169 Adult Fat Body    187.1 Adult Salivary Gland    256.8 Adult Heart    116.75 Adult VirginFemale Spermatheca    266.1 Adult InseminatedFemale Spermatheca    272.6 Adult Ovary    114 Adult Testis    47.4 Adult Male Accessory Gland    408.2 Adult Carcass    148.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    100.9   NA  Eye    98.45   NA  Brain    46   83.15  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    74.6   NA  Crop    205.2   274.6  Midgut    219.1   251.7  Hindgut    127.9   161.9  Malpighian Tubules    169   191.6  Fat Body    187.1   159.8  Salivary Gland    256.8   NA  Heart    116.75   157.125  Trachea    NA   NA  VirginFemale Spermatheca    266.1   NA  InseminatedFemale Spermatheca    272.6   NA  Ovary    114   NA  Testis    47.4   NA  Male Accessory Gland    408.2   117.125  Carcass    148.9 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_23
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001189 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3095-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for hfw Stages(s) 1-3 Stages(s) 4-6 Stages(s) 11-12
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal hfw1 hfw2 hfw3 hfw4 hfw5 hfw7 lethal | pupal stage hfw7 lethal | recessive hfw3 hfw4 hfw7 viable, with Scer\GAL4pnr-MD237 hfwGD6373 viable | male hfw6 viable | reduced hfw5 Other Phenotypes Allele visible | recessive hfw5 Phenotype manifest in Allele adult abdomen hfw5 wing hfw5
Classical Alleles ( 9 )
For All Classical Alleles Show
Allele of hfw Class Mutagen Stocks Known lesion hfwG706 P-element activity 1 -- hfwNP7175 1 -- hfw1 0 -- hfw2 ethyl methanesulfonate 0 -- hfw3 ethyl methanesulfonate 0 -- hfw4 ethyl methanesulfonate 0 -- hfw5 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- hfw6 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- hfw7 ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of hfw Class Mutagen Stocks Known lesion hfwGD6373 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes hfwHM05047 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes hfwKK104414 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes hfw+tSWI3 in vitro construct - genomic fragment 0 Yes hfw+tSWI4 in vitro construct - genomic fragment 0 Yes hfwtSWI1 in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Duplicated in	Dp(1;f)1337 (Rayle and Hoar, 1969) Dp(1;Y)2E (Aizenzon and Belyaeva, 1982) Dp(1;Y)2E-C (Rayle and Hoar, 1969) Dp(1;Y)dor9T (Belyaeva et al., 1982) Dp(1;Y)dor13T (Belyaeva et al., 1982) Dp(1;Y)Sz280 (Belyaeva et al., 1987) Dp(1;Y)y221T (Belyaeva et al., 1980, Belyaeva et al., 1982) Dp(1;Y)y240T (Belyaeva et al., 1980) Dp(1;Y)y253T (Belyaeva et al., 1980, Belyaeva et al., 1982, Aizenzon and Belyaeva, 1982) Dp(1;Y)y267g19.1 (Belyaeva et al., 1980, Aizenzon and Belyaeva, 1982) Dp(1;Y)y267g24.2 (Belyaeva et al., 1980, Belyaeva et al., 1982, Aizenzon and Belyaeva, 1982, Protopopov et al., 1991)
Not duplicated in	Dp(1;f)3 (Rayle and Hoar, 1969) Dp(1;f)18 (Rayle and Hoar, 1969) Dp(1;f)101 (Rayle and Hoar, 1969, Belyaeva et al., 1980, Aizenzon and Belyaeva, 1982) Dp(1;Y)Sz280 (Belyaeva et al., 1982, Aizenzon and Belyaeva, 1982, Protopopov et al., 1991) Dp(1;Y)y59b (Belyaeva et al., 1980, Aizenzon and Belyaeva, 1982)
Disrupted in	Df(1)RA19 (Belyaeva et al., 1980, Belyaeva et al., 1982, Aizenzon and Belyaeva, 1982) Df(1)St472 (Aizenzon and Belyaeva, 1982) Ts(1Lt;YLt)G20 (Belyaeva et al., 1987) Ts(1Lt;YSt)B131 (Belyaeva et al., 1987)
Not disrupted in	Df(1)At127 (Aizenzon and Belyaeva, 1982) Df(1)br25 (Belyaeva et al., 1980, Belyaeva et al., 1987) Df(1)br-rv1 (Belyaeva et al., 1987) Df(1)S39 (Belyaeva et al., 1980, Belyaeva et al., 1982, Aizenzon and Belyaeva, 1982, Belyaeva et al., 1987, Protopopov et al., 1991) Df(1)St490 (Belyaeva et al., 1987) Df(1)sta (Belyaeva et al., 1980, Aizenzon and Belyaeva, 1982, Belyaeva et al., 1987) In(1)br103 (Belyaeva et al., 1987)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6373} NA P{KK104414} NA P{TRiP.HM05047} NA characterization construct P{SWI1} NA P{SWI3} NA P{SWI4} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system P{GawB}hfwNP7175 No insertion of mobile activating element P{EP}hfwG706 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
	There is no information supporting a cellular component or molecular function term for this gene. (Based on a review of available data on: 2006-10-26)
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
intracellular signal transduction inferred from mutant phenotype (assigned by UniProtKB) (Schwartz et al., 2004) pupariation inferred from mutant phenotype (assigned by UniProtKB) (Schwartz et al., 2004) response to ecdysone inferred from mutant phenotype (assigned by UniProtKB) (Schwartz et al., 2004)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions hfw allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 57671 DroID - A comprehensive database of gene and protein interactions. • FBgn0001189 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31120
Orthologs
Genome-wide drosophilid orthologs	Dana\GF22167 Dere\GG12873 Dgri\GH24532 Dmoj\GI16497 Dper\GL14268 Dpse\GA15922 Dsec\GM19159 Dsim\GD16565 Dvir\GJ16041 Dwil\GK25026 Dyak\GE16702
Curated drosophilid orthologs	Dfun\hfw   Dhyd\hfw   Dkan\hfw   Dmer\hfw   Dpar\hfw   Dpse\GA15922   Drep\hfw   Dvir\hfw
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL011387-PA Aedes aegypti (mosquito) AGAP000601-PA Anopheles gambiae (mosquito) XP_395627.3 Apis mellifera (honey bee) BGIBMGA009839-PA Bombyx mori (silk worm) CPIJ014039 Culex pipens (mosquito) 311374 Daphnia pulex (daphnia) ENSGACP00000006832 Gymnopilus aculeatus (mushroom) ISCW020221-PA Ixodes scapularis (deer tick) XP_001599400.1 Nasonia vitripennis (wasp) XP_967806.2 Tribolium castaneum (red flour beetle) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14619 NV18058 LH12124 FBgn0234199 FBgn0226985 FBgn0203226 FBgn0174061 JGI_V11_311374 FBgn0086366 FBgn0151873 FBgn0139245 FBgn0131988 FBgn0105147 FBgn0099166 CPIJ014039 BGIBMGA009839 ACYPI26723 GB19822 AGAP000601 AAEL012958 AAEL011387 PHUM097950 GLEAN_03404
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	26596 P{EP}hfwG706 w* 28561 y1 v1; P{TRiP.HM05047}attP2
Kyoto	114120 P{GawB}hfwNP7175 w* / FM7c
VDRC	v104214 P{KK104414}VIE-260B v14524 w1118; P{GD6373}v14524
Genomic Clones ( 2 )
	BACR03E12 BACR33A08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 18 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE03173
Other clones	FI03214 RT10243
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE44618
Other clones	8658 65000 214481.48 273613 273649 CK01.142A.H1 EK107243 EK109907 EK191231 EK300630 EK300661 ESG0112a.B21.1_G03 GH23628 IP02470
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0001189 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31120
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: hfw CG3095 (FlyBase, 1996-)
Additional comments	Source for merge of hfw CG3095 was sequence comparison (date:040402). (FlyBase, 1996-)
Other Comments
	Complementation test between the "hfw1" allele described by FBrf0018667 with any "swi" mutant alleles has not been possible, since the "hfw1" stock was lost by the time that "swi" mutant alleles were obtained. "hfw" and "swi" map to the same cytological interval and mutants show similar phenotypes, making it very likely that they are allelic. (Schwartz et al., 2004) Localisation of hfw, dor and br are clustered in the X chromosomes of taxonomically distant Drosophila species, suggesting an evolutionary significance of such an organisation. (Kokoza et al., 1992) hfw has been located within a puff on the telomeric chromosome of D.funebris, D.virilis, D.hydei, D.repleta, D.mercatorum and D.paranaensis, within a puff on the distal part of the X chromosome of D.kanekoi and within a puff on the proximal portion of the X chromosome of D.pseudoobscura.pseudoobscura. (Kokoza et al., 1991) The hfw locus is subject to T(1;2)dorvar7 position effect variegation. (Demakova et al., 1988) Hormone incubation of mutant salivary glands in vitro and hormone injection of mutants demonstrates the hfw gene product is necessary for induction of late puffs. (Belyaeva and Zhimulev, 1982) Some swi mutants exhibit puparium formation of the anterior half of the body only, this phenomenon is characteristic of the mutant hfw, localised to the same region. These results suggest the swi mutants belongs to the hfw group. (Belyaeva et al., 1980) Recessive lethal; for some alleles, development arrested in third instar, the anterior half initiating puparium formation while the posterior half remains larval. Extent of development influenced by administration of ecdysone and by temperature; pupariation occasionally completed at 18oC. Some alleles yield a few survivors with characteristic wing abnormalities and occasionally swollen abdomens.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_130577 RefSeq (Proteins) • NP_569933 DDBJ / EMBL / GenBank • AAF45654 AAL48553 AJ626646 AL021726 AY070931 BI163705 CAA16810 CAF25166 Entrez Gene - A searchable database of RefSeq genes. • 31120 UniProtKB/TrEMBL • Q9W568
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Leucine-rich repeat (IPR001611)
Linkouts
	BioGRID - A database of protein and genetic interactions • 57671 DroID - A comprehensive database of gene and protein interactions. • FBgn0001189 DRSC - Results from RNAi screens. • FBgn0001189 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001189 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3095-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0001189 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31120 InParanoid A subset of ortholog calls from InParanoid. • AAEL011387-PA Aedes aegypti (mosquito) AGAP000601-PA Anopheles gambiae (mosquito) XP_395627.3 Apis mellifera (honey bee) BGIBMGA009839-PA Bombyx mori (silk worm) CPIJ014039 Culex pipens (mosquito) 311374 Daphnia pulex (daphnia) ENSGACP00000006832 Gymnopilus aculeatus (mushroom) ISCW020221-PA Ixodes scapularis (deer tick) XP_001599400.1 Nasonia vitripennis (wasp) XP_967806.2 Tribolium castaneum (red flour beetle) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31120 modMine - Data generated by the modENCODE project. • FBgn0001189 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14619 NV18058 LH12124 FBgn0234199 FBgn0226985 FBgn0203226 FBgn0174061 JGI_V11_311374 FBgn0086366 FBgn0151873 FBgn0139245 FBgn0131988 FBgn0105147 FBgn0099166 CPIJ014039 BGIBMGA009839 ACYPI26723 GB19822 AGAP000601 AAEL012958 AAEL011387 PHUM097950 GLEAN_03404
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	CG3095 (Schwartz et al., 2004, Benos, 2000.12.13, Murthy et al., 2008, Keleman et al., 2009.8.5, Perkins et al., 2009) CT10406 (Hynes and Zhao, 2000) EG:171E4.2 (Schwartz et al., 2004, Benos et al., 2001, Benos et al., 2000, Giot et al., 2003, ) hfw   l(1)2Bf   l(1)nfw   swi (Schwartz et al., 2004, Makunin et al., 1999, Mizzen and Allis, 1998, Kokoza et al., 1992, Kokoza et al., 1991, Protopopov et al., 1991, Solovyeva and Belyaeva, 1989, Demakova et al., 1988, Demakova and Belyaeva, 1988, Belyaeva et al., 1987, Aizenzon and Belyaeva, 1982, Belyaeva et al., 1982, Belyaeva et al., 1981, Belyaeva et al., 1980, Schwartz, 2004.2.1, Schwartz et al., 2004) SWI (Gellon and McGinnis, 1998, Cairns, 1998)
Name Synonym	halfway   singed wings (Schwartz et al., 2004, Schwartz, 2004.2.1, Murthy et al., 2008) singed-wings
Secondary FlyBase IDs
	FBgn0023532
References ( 44 )
Generate a list of	All references relating to this gene ( 44 )
List References by type	Research paper  ( 19 ) Supplementary material  ( 5 ) Review  ( 6 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 1 ) FlyBase analysis  ( 4 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Book  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2010 Show research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...