swi, EG:171E4.2 , singed wings
Gene model reviewed during 5.39
Gene model reviewed during 5.46
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\hfw using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\hfw in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Complementation test between the "hfw1" allele described by FBrf0018667 with any "swi" mutant alleles has not been possible, since the "hfw1" stock was lost by the time that "swi" mutant alleles were obtained. "hfw" and "swi" map to the same cytological interval and mutants show similar phenotypes, making it very likely that they are allelic.
hfw has been located within a puff on the telomeric chromosome of D.funebris, D.virilis, D.hydei, D.repleta, D.mercatorum and D.paranaensis, within a puff on the distal part of the X chromosome of D.kanekoi and within a puff on the proximal portion of the X chromosome of D.pseudoobscura.pseudoobscura.
Hormone incubation of mutant salivary glands in vitro and hormone injection of mutants demonstrates the hfw gene product is necessary for induction of late puffs.
Some swi mutants exhibit puparium formation of the anterior half of the body only, this phenomenon is characteristic of the mutant hfw, localised to the same region. These results suggest the swi mutants belongs to the hfw group.
Recessive lethal; for some alleles, development arrested in third instar, the anterior half initiating puparium formation while the posterior half remains larval. Extent of development influenced by administration of ecdysone and by temperature; pupariation occasionally completed at 18oC. Some alleles yield a few survivors with characteristic wing abnormalities and occasionally swollen abdomens.