FB2020_06, released Dec 22, 2020

Gene: Dmel\His2A

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General Information
Symbol
Dmel\His2A
Species
D. melanogaster
Name
Histone H2A
Annotation Symbol
Feature Type
protein_coding_gene
FlyBase ID
FBgn0001196
Gene Model Status
Not Applicable
Stock Availability
21 publicly available
Other Summaries
Also Known As

H2A, histone, core histone, HisC, H2A.1

Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (8 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables DNA binding
inferred from electronic annotation with InterPro:IPR002119, InterPro:IPR007125
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables protein heterodimerization activity
inferred from electronic annotation with InterPro:IPR009072
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in larval somatic muscle development
inferred from mutant phenotype
(Schnorrer et al., 2010)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
located_in chromosome
inferred from direct assay
(Leach et al., 2000)
located_in nucleus
inferred from direct assay
(Leach et al., 2000)
located_in polytene chromosome band
inferred from direct assay
(Leach et al., 2000)
located_in polytene chromosome
inferred from direct assay
(Leach et al., 2000)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
part_of nucleosome
traceable author statement
(Leach et al., 2000)
inferred from electronic annotation with InterPro:IPR002119
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the histone H2A family. (P84051)
Protein Signatures (InterPro)
Summaries
Protein Function (UniProtKB)
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
(UniProt, P84051)
Summary (Interactive Fly)

Chromatin component - a core histone that can be modified by ubiquitination - a target of polycomb gene silencing - involved in trans-histone regulation through histone H3 - H2A monoubiquitination promotes histone H3 methylation in Polycomb repression

Gene Model and Products
Number of Transcripts
0
Number of Unique Polypeptides
0
Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Sequence Ontology: Class of Gene
member_gene_array
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Polypeptides with Identical Sequences

 

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

(UniProt, P84051)
Post Translational Modification

The chromatin-associated form, but not the free cytoplasmic form, is phosphorylated on Thr-120 by NHK-1 during mitosis, and dephosphorylated during S-phase. Also phosphorylated on Thr-120 by NHK-1 during prophase I of meiosis; which is required for acetylation of H3 'Lys-14' and H4 'Lys-5', diassembly of the synaptonemal complex, and karyosome formation.

Monoubiquitination of Lys-119 by sce/dRING gives a specific tag for epigenetic transcriptional repression.

Phosphorylation on Ser-2 is enhanced during mitosis. Phosphorylation on Ser-2 directly represses transcription (By similarity).

(UniProt, P84051)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\His2A using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 14
central nervous system

Comment: replicating cells

(Lanzotti et al., 2002)
midgut | restricted

Comment: endoreplicating cells

(Lanzotti et al., 2002)
Additional Descriptive Data

His2A transcript is restricted to replicating cells.

(Lanzotti et al., 2002)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
fertilized egg stage
female pronucleus
(Loppin et al., 2001)
male pronucleus
(Loppin et al., 2001)
adult stage
spermatozoon
(Loppin et al., 2001)
spermatogenesis
elongation stage spermatid
(Loppin et al., 2001)
pre-elongation spermatid
(Loppin et al., 2001)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data

His4 and His2A that was mono or poly acetylated is detected associated with nuclei of developing spermatids until late stages. During late spermatid development and in mature spermatazoa these proteins can no longer be detected (and are presumably replaced by sperm specific chromatin packaging proteins). However, shortly after fertilization His4 and His2A immunoreactivity reappears associated with the male pronuclear DNA.

(Loppin et al., 2001)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in chromosome
inferred from direct assay
(Leach et al., 2000)
located_in nucleus
inferred from direct assay
(Leach et al., 2000)
located_in polytene chromosome band
inferred from direct assay
(Leach et al., 2000)
located_in polytene chromosome
inferred from direct assay
(Leach et al., 2000)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\His2A in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 1 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of His2A
Transgenic constructs containing regulatory region of His2A
Deletions and Duplications ( 3 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4pnr-MD237
lethal - all die during larval stage, with Scer\GAL4Mef2.PR
Phenotype manifest in
Allele
embryonic/larval somatic muscle, with Scer\GAL4Mef2.PR
sarcomere, with Scer\GAL4Mef2.PR
Z disc, with Scer\GAL4Mef2.PR
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (0)
No records found.
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (0)
No records found.
Rattus norvegicus (Norway rat) (0)
No records found.
Xenopus tropicalis (Western clawed frog) (0)
No records found.
Danio rerio (Zebrafish) (0)
No records found.
Caenorhabditis elegans (Nematode, roundworm) (0)
No records found.
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( None identified )
No orthologies identified
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( None identified )
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( None identified )
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( None identified )
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )
No non-Arthropod Metazoa orthologies identified
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser
    View in Interactions Browser
    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    His2A
    pull down, western blot, split luciferase complementation, luminiscence technology
    (Kolkhof et al., 2017, Fei et al., 2015)
    His2A - Acf
    pull down, molecular weight estimation by staining
    (Eberharter et al., 2004)
    His2A - CG11700
    split luciferase complementation, luminiscence technology
    (Kolkhof et al., 2017)
    His2A - Caf1-55
    pull down, autoradiography
    (Tie et al., 2007)
    His2A - Dek
    affinity technology, ion exchange chromatography, Identification by mass spectrometry, pull down, western blot, anti tag coimmunoprecipitation
    (Sawatsubashi et al., 2010)
    His2A - E(z)
    pull down, Identification by mass spectrometry
    (Kalb et al., 2014)
    His2A - Fkbp39
    anti tag coimmunoprecipitation, Identification by mass spectrometry
    (Edlich-Muth et al., 2015)
    His2A - His1
    cosedimentation, molecular weight estimation by staining, nuclear magnetic resonance, predetermined participant
    (Zhou et al., 2016, Zhou et al., 2013)
    His2A - His2Av
    split luciferase complementation, luminiscence technology
    (Kolkhof et al., 2017)
    His2A - His2B
    cosedimentation, molecular weight estimation by staining, split luciferase complementation, luminiscence technology, cross-linking study, affinity chromatography technology, molecular sieving, cosedimentation through density gradient
    (Kolkhof et al., 2017, Fei et al., 2015, Klinker et al., 2014, Anderson et al., 2010, Ito et al., 1996, Ito et al., 1996, Bulger et al., 1995)
    His2A - His3
    cosedimentation, molecular weight estimation by staining, cosedimentation through density gradient, molecular sieving
    (Fei et al., 2015, Klinker et al., 2014, Ito et al., 1996, Ito et al., 1996, Bulger et al., 1995)
    His2A - His4
    cosedimentation, molecular weight estimation by staining, molecular sieving, cosedimentation through density gradient, split luciferase complementation, luminiscence technology
    (Kolkhof et al., 2017, Fei et al., 2015, Klinker et al., 2014, Ito et al., 1996, Ito et al., 1996, Bulger et al., 1995)
    His2A - Jabba
    split luciferase complementation, luminiscence technology
    (Kolkhof et al., 2017)
    His2A - Jarid2
    pull down, Identification by mass spectrometry
    (Kalb et al., 2014)
    His2A - Nap1
    cosedimentation through density gradient, molecular weight estimation by staining, cosedimentation, anti bait coimmunoprecipitation, western blot
    (Emelyanov et al., 2014, Ito et al., 1996, Ito et al., 1996, Bulger et al., 1995)
    His2A - Nlp
    anti bait coimmunoprecipitation, molecular weight estimation by staining, cosedimentation through density gradient, cosedimentation
    (Emelyanov et al., 2014, Ito et al., 1996)
    His2A - Nph
    cosedimentation through density gradient, molecular weight estimation by staining
    (Emelyanov et al., 2014)
    His2A - P32
    cosedimentation through density gradient, molecular weight estimation by staining
    (Emelyanov et al., 2014)
    His2A - Parp
    pull down, western blot
    (Thomas et al., 2014)
    His2A - Pc
    affinity technology, peptide array, western blot
    (Stein et al., 2013)
    His2A - Sce
    enzymatic study, western blot
    (Lagarou et al., 2008)
    His2A - Tip60
    enzymatic study, autoradiography
    (Kusch et al., 2014)
    His2A - cid
    anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, Identification by mass spectrometry
    (Zhang et al., 2012, Dalal et al., 2007)
    His2A - esc
    pull down, Identification by mass spectrometry
    (Kalb et al., 2014)
    His2A - mof
    enzymatic study, autoradiography
    (Smith et al., 2000)
    RNA-protein
    Physical Interaction
    Assay
    References
    His2A - vig
    anti tag coimmunoprecipitation, quantitative reverse transcription pcr, electrophoretic mobility shift assay, autoradiography
    (Tsui et al., 2018)
    His2A - vig2
    anti tag coimmunoprecipitation, quantitative reverse transcription pcr
    (Tsui et al., 2018)
    Summary of Genetic Interactions
    esyN Network Diagram
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
    (UniProt, P84051 )
    Linkouts
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    Recombination map

    2-55

    Cytogenetic map
    39D3-39E1
    Sequence location
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    39D3-39E1
    Left limit from in situ hybridisation (FBrf0029738) Right limit from inclusion within Df(2L)L138D-XR (citation unavailable)
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    39D-39E
    (determined by in situ hybridisation)
    (Fitch et al., 1990, Lifton et al., 1978)
    39D3-39E2
    (determined by in situ hybridisation)
    (Pardue et al., 1977)
    Experimentally Determined Recombination Data
    Location

    2-55

    Left of (cM)
    Right of (cM)
    Notes

    2-54.6

    Stocks and Reagents
    Stocks (21)
    Genomic Clones (0)
     
      cDNA Clones (0)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
              Other clones
                RNAi and Array Information
                Linkouts
                Antibody Information
                Laboratory Generated Antibodies
                 

                polyclonal

                (Doyen et al., 2013, Egelhofer et al., 2011)

                monoclonal

                (Egelhofer et al., 2011)
                Commercially Available Antibodies
                 
                Other Information
                Relationship to Other Genes
                Other Comments

                The ATPase activity of Iswi is completely inhibited by each of the four histone tails (His2A, His2B, His3 and His4), results indicate a novel role for the flexible histone tails in chromatin remodeling by Iswi.

                (Georgel et al., 1997)

                The codon bias of the histone genes from D.melanogaster and D.hydei illustrates that the generalisation that abundantly expressed genes have a high codon bias and low rates of silent substitution does not hold for the histone genes.

                (Fitch and Strausbaugh, 1993)

                The position of the homologous histone gene repeats within the nuclei of early embryo cells has been investigated. The two homologous histone gene clusters are distinct and separate through all stages of the cell cycle up to nuclear cycle 13. During interphase of cycle 14, the two clusters colocalise with high frequency, and move from near the midline of the nucleus towards the apical side.

                (Hiraoka et al., 1993)

                DNA replication of the 5kb histone gene repeating unit in tissue culture cells (Drosophila Kc cells) initiates at multiple sites located within the repeating unit. Several replication pause sites are located at 5' upstream regions of some histone genes.

                (Shinomiya and Ina, 1993)

                DNaseI footprinting analysis reveals core histones His2A, His2B, His3 and His4 (but not His1) bind to the kni, Kr and Ubx minimal enhancer elements in a periodic manner.

                (Kerrigan and Kadonaga, 1992)

                The genomic organisation of the histone genes in D.hydei closely resembles that of D.melanogaster.

                (Kremer and Hennig, 1990)

                One H2A-like sequence variant has been found (Donahue, Palmer, Condie, Sabatini, and Blumenfeld, 1986); see His2Av.

                Encodes Histone-2A. See HIS-C record.

                Origin and Etymology
                Discoverer
                Etymology
                Identification
                External Crossreferences and Linkouts ( 15 )
                Sequence Crossreferences
                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                Other crossreferences
                InterPro - A database of protein families, domains and functional sites
                Linkouts
                FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                Synonyms and Secondary IDs (22)
                Reported As
                Symbol Synonym
                DmeH2a
                (Fitch and Strausbaugh, 1993)
                H2A
                (Amati and Gasser, 1990)
                H2A
                (Kolesnikova et al., 2020, Pirani et al., 2020, Chittori et al., 2019, Yang et al., 2019, Daou et al., 2018, Tsui et al., 2018, Zheng et al., 2018, Khuong et al., 2017, Kitevski-LeBlanc et al., 2017, Kolkhof et al., 2017, Ramachandran et al., 2017, Rowley et al., 2017, Strom et al., 2017, Yang and Ioshikhes, 2017, Bayona-Feliu et al., 2016, Doiguchi et al., 2016, Elnfati et al., 2016, Kahn et al., 2016, Kavi et al., 2016, Messina et al., 2016, Nakashima et al., 2016, Ozawa et al., 2016, Shih et al., 2016, Zhou et al., 2016, Edlich-Muth et al., 2015, Fei et al., 2015, Horard and Loppin, 2015, Pengelly et al., 2015, Emelyanov et al., 2014, Fereres et al., 2014, Klinker et al., 2014, Kusch et al., 2014, Messina et al., 2014, Thomas et al., 2014, Bharadwaj et al., 2013, Doyen et al., 2013, Eichinger et al., 2013, Guglielmi et al., 2013, Schaaf et al., 2013, Stein et al., 2013, Wang et al., 2013, Xing et al., 2013, Zhou et al., 2013, Dunlap et al., 2012, Gutiérrez et al., 2012, Ito et al., 2012, Li et al., 2012, Li et al., 2012, Lo et al., 2012, Villar-Garea et al., 2012, Xie et al., 2012, Zhou et al., 2012, Chen et al., 2011, Egelhofer et al., 2011, Gibert and Karch, 2011, Lorbeck et al., 2011, Olins et al., 2011, Regnard et al., 2011, Siudeja et al., 2011, Anderson et al., 2010, Beck et al., 2010, Bryson et al., 2010, Deal et al., 2010, Guertin and Lis, 2010, Lancaster et al., 2010, Makde et al., 2010, Sawatsubashi et al., 2010, Scheuermann et al., 2010, Weber et al., 2010, Kolesnikova et al., 2009, Lu et al., 2009, Morciano et al., 2009, Sakai et al., 2009, Sullivan et al., 2009, Bao et al., 2008, Barreau et al., 2008, Cakouros et al., 2008, Clapier et al., 2008, Frydrychova et al., 2008, Hanai et al., 2008, Krajewski, 2008, Lagarou et al., 2008, Bell et al., 2007, Camporeale et al., 2007, Corona et al., 2007, Dalal et al., 2007, Dalal et al., 2007, Isogai et al., 2007, Pinnola et al., 2007, Rathke et al., 2007, Tie et al., 2007, Wagner et al., 2007, Wagner et al., 2007, Brasaemle and Hansen, 2006, Camporeale et al., 2006, Furuyama et al., 2006, Mendjan et al., 2006, Raisner and Madhani, 2006, Santoso and Kadonaga, 2006, Dudnik et al., 2005, Ivanovska et al., 2005, Jin, 2005, Lusser et al., 2005, Aihara et al., 2004, Kusch et al., 2004, Kusch et al., 2004, Lippman and Martienssen, 2004, Morales et al., 2004, Wang et al., 2004, Furukawa et al., 2003, Kakita et al., 2003, Schwartz et al., 2003, Staeva-Vieira et al., 2003, Blower and Karpen, 2002, Cao et al., 2002, Clapier et al., 2002, Levenstein and Kadonaga, 2002, Smith, 2002, Yu and Wolfner, 2002, Berloco et al., 2001, Hamiche et al., 2001, Katsani et al., 2001, Loppin et al., 2001, Mello and Almouzni, 2001, Mizuguchi et al., 2001, Nakagawa et al., 2001, Kal et al., 2000, Leach et al., 2000, Mizzen and Allis, 2000, Pham and Sauer, 2000, Smith et al., 2000, Verreault, 2000, Baldo et al., 1999, Borgnetto et al., 1999, Carrier et al., 1999, Hamiche et al., 1999, Reim et al., 1999, Stuckenholz et al., 1999, Schienman et al., 1998, Sobel et al., 1998, Strausbaugh et al., 1998, Walker and Bownes, 1998, Georgel et al., 1997, Grunstein, 1997, Ito et al., 1996, Ito et al., 1996, Sommer and Strausbaugh, 1996, Strausbaugh and Williams, 1996, Wolffe and Pruss, 1996, Blank and Becker, 1995, Sobel et al., 1994, O'Brien and Lis, 1993, Shinomiya and Ina, 1993, Becker and Wu, 1992, Kas and Laemmli, 1992, Kerrigan and Kadonaga, 1992, Pauli et al., 1992, Harisanova and Ralchev, 1991, Harisanova et al., 1991, O'Brien and Lis, 1991, Udvardy and Schedl, 1991, Fitch et al., 1990, Kremer and Hennig, 1990, Domier et al., 1986, Levinger and Varshavsky, 1982)
                H2A.1
                (Clarkson et al., 1999, van Daal et al., 1988)
                H2A1
                (Redon et al., 2002)
                H2a
                (Welch et al., 2015, Salzler et al., 2013, Godfrey et al., 2006, Dominski et al., 2002, Lanzotti et al., 2002, Rodriguez-Trelles et al., 2000, Shinomiya and Ina, 1991)
                His2A
                (Kirkland et al., 2020, Liu et al., 2020, Sherer et al., 2020, Shindo and Amodeo, 2019, Kwong et al., 2015, McKay et al., 2015, Colinet et al., 2013, Kozhevnikova et al., 2012, Aldaz et al., 2010, Günesdogan et al., 2010, Oliveira et al., 2010, Schnorrer et al., 2010, Graham et al., 2009, Gilchrist et al., 2008, Keranen et al., 2006, Emery et al., 2005)
                His2a
                (Shopland and Lis, 1996)
                HisC
                (Greil et al., 2003, van Steensel et al., 2001)
                dH2A
                (Brittle et al., 2007, Dominski et al., 2005)
                dH2a
                (Yang et al., 2009)
                his
                (Matsushima and Kaguni, 2007)
                hist
                (Häsemeyer et al., 2009)
                histone
                (Corpet and Almouzni, 2007)
                Name Synonyms
                Histone
                (Hutterer et al., 2006, Parsons et al., 2003, Breiling et al., 1999)
                Histone 2A
                (Lu et al., 2009)
                Histone H2A
                Histone2A
                (Keranen et al., 2006)
                HistoneH2A
                (Kurihara et al., 2020)
                core histone
                (Xia et al., 2003, Livengood et al., 2002)
                histone
                (Wagner et al., 2008, Machida et al., 2005, Alexiadis et al., 2004, Bao et al., 2004, Ishii et al., 2004, Kagansky et al., 2004, Korber and Horz, 2004, Matsushima et al., 2004, McKee, 2004, Schwanbeck et al., 2004, Duringer et al., 2003, McBryant et al., 2003, Crevel et al., 2001, Crevel et al., 2001, Donaghue et al., 2001, Gemkow et al., 2001, Brent et al., 2000, Foe et al., 2000, Marley et al., 2000, McKee et al., 2000, Fitch and Wakimoto, 1998, Fung et al., 1998, Troyer et al., 1998, Baker et al., 1993)
                histone H2A
                (Scheuermann et al., 2010, Bao et al., 2008, Lagarou et al., 2008, Hyllus et al., 2007, Pinnola et al., 2007, Rathke et al., 2007, Rathke et al., 2007, Ringrose and Paro, 2007, Muller and Kassis, 2006)
                histone H2a
                (Godfrey et al., 2006, Lanzotti et al., 2002)
                Secondary FlyBase IDs
                  Datasets (0)
                  Study focus (0)
                  Experimental Role
                  Project
                  Project Type
                  Title
                  References (321)