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Gene Dmel\His2Av

General Information
Symbol	Dmel\His2Av	Species	D. melanogaster
Name	Histone H2A variant	Annotation symbol	CG5499
Feature type	protein_coding_gene	FlyBase ID	FBgn0001197
Gene Model Status	Current	Stock availability	19 publicly available
Also Known As	H2Av, H2AvD, His2AvD, H2A.Z, l(3)05146, H2AX, γ-His2Av, l(3)97Dd, Hist
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	97D3-97D3	Sequence location	3R:22,692,653..22,694,630 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Histone H2A variant is referred to in FlyBase by the symbol Dmel\His2Av (CG5499, FBgn0001197). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: DNA binding. There is experimental evidence that it is involved in the biological process: response to DNA damage stimulus. 38 alleles are reported. The phenotypes of these alleles are annotated with: eye; anterior crossvein; tarsal segment; mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: Histone H2A; Histone core; Histone-fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, larval hindgut, larval salivary gland, larval trachea, adult ovary, adult male reproductive system, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult thoracico-abdominal ganglion, adult crop, larval/adult midgut, adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, adult spermathecae, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1639087_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of His2Av. Gene sequence location is 3R:22692653..22694630.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Wang et al., 2011, PLoS Genet. 7(8): e1002227
FB2012_01	References Matsuda et al., 2010, PLoS ONE 5(9): e12768 Bryson et al., 2010, Fly 4(3): 258--265 Lancaster et al., 2010, PLoS Genet. 6(10): e1001179 Lake et al., 2011, PLoS Genet. 7(2): e1002005 Metzstein and Krasnow, 2006, PLoS Gen. 2(12): Sequence features HFA16702 BKN28652
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 97D3-97D3   Limits computationally determined from genome sequence between P{lacW}scribj7B3 and P{lacW}His2AvL1602
Experimentally Determined Cytological Location
Cytogenetic map Notes References 97D3-97D6   (determined by in situ hybridisation)   (Spradling et al., 1999) 97D3-97D6     (BDGP Project Members, 1994-1999) 97C-97D   (determined by in situ hybridisation)   (van Daal et al., 1988)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes	The order from centromere to telomere is l(3)97Da l(3)97Db l(3)97Dc. His2Av is likely to map near to l(3)97Db. (Knibb et al., 1993)
Gene Model & Products
Please see the GBrowse view of Dmel\His2Av for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) His2Av-RA FBtr0085062  NM_079795   910   141
Additional Transcript Data & Comments
Reported size (kB)	0.9 (northern blot) (van Daal and Elgin, 1992)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein His2Av-PA   FBpp0084434   15.0   141   10.94     NP_524519   AAF56631
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Histone H2A (IPR002119) Histone core (IPR007125) Histone-fold (IPR009072)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202275   AA247059   AA439001   AA441058   AA538925   AA539608   AA539670   AA696092   AA696558   AA697053   AA735581   AA941746   AA941799   AA948887   AA949016   AA949372   AA949445   AA979213   AA979366   AE014297 AAF56631   AI239040   AI259713   AI260944   AI294230   AI296090   AI389887   AI455166   AI512673   AI518577   AI519027   AI520415   AI543447   AQ026206   AQ026244   AQ073083   AY118910 AAM50770   BG635623   BG636860   BI164805   BI166826   BI169862   BI170297   BI170780   BI171122   BI172363   BI172827   BI213258   BI215288   BI215508   BI216984   BI228208   BI229511   BI232698   BI232752   BI232817   BI236833   BI237147   BI238689   BI238817   BI239092   BI240023   BI356520   BI361732   BI366661   BI367845   BI368094   BI368170   BI368517   BI368642   BI374441   BI483327   BI485416   BI485582   BI486326   BI486742   BI639364   BP543249   BP543250   BP543981   BP543982   BP545413   BP545414   BP546257   BP546304   BP547559   BP548340   BP554608   BP554609   BP555441   BP555442   BP557934   BP557935   BP559320   BP559321   BQ103008   BQ103261   BX008098   CO177038   CO180007   CO189301   CO273789   CO277141   CO280490   CO287140   CO291811   CO293734   CO294761   CO295295   CO295316   CO296982   CO307900   CO310001   CO312134   CO313000   CO319874   CO323049   CO331914   CO335368   CO342974   EC060528   EC065123   EC072909   EC075801   EC078567   EC080218   EC086843   EC087469   EC194826   EC198305   EC200676   EC201640   EC201651   EC204417   EC207171   EC209414   EC211647   EC212743   EC212909   EC213561   EC215770   EC221374   EC228148   EC232235   EC247473   EC252363   EC264126   EC264941   EL881954   EV575537   EV577860   EV578359   EV579487   EV579943   EV580092   EV580964   EV583788   EV584421   EV585105   EV593072   EV595137   EV598361   GH748326   GH759925   GH790605   GH823222   GH824984   GH842890   GH849388   GH861167   GH861886   GH862226   GH862328   GH870014   GH876038   GH895494   GH895916   GH896308   GH916951   GH917190   GH929129   S42733 AAB22897   X07485 CAA30370   X15549 CAA33555
UniProtKB/Swiss-Prot	P08985
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 15     (van Daal and Elgin, 1992) Comment:reference states 0-12 hr AEL northern blot Stage Tissue/Position (including subcellular localization) Reference adult stage | female     (van Daal and Elgin, 1992)
Additional Descriptive Data
	His2Av810 RNA accumulates to approximately the same level as the wild type RNA. (van Daal and Elgin, 1992) His2Av transcripts are abundant in adult females and in embryos throughout the first 12 hours. (van Daal and Elgin, 1992)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Dorus et al., 2006) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
	The His2Av protein is present at nearly constant levels in all developmental stages tested. (van Daal and Elgin, 1992)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0001197    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0001197 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0001197 expression level Developmental Stage   Expression Level embryo 00-02hr    48736 embryo 02-04hr    83257 embryo 04-06hr    92038 embryo 06-08hr    92575 embryo 08-10hr    77290 embryo 10-12hr    42946 embryo 12-14hr    31002 embryo 14-16hr    27027 embryo 16-18hr    20341 embryo 18-20hr    11245 embryo 20-22hr    21867 embryo 22-24hr    17066 larva L1    9255 larva L2    11172 larva L3 12hr old    5828 larva L3 puffstage 1-2    7915 larva L3 puffstage 3-6    10904 larva L3 puffstage 7-9    11712 white prepupae new    12166 white prepupae 12hr    13231 white prepupae 24hr    15339 pupae 2d postWPP    5593 pupae 3d postWPP    2919 pupae 4d postWPP    4421 adult male 01day    2963 adult male 05day    3717 adult male 30day    3859 adult female 01day    16410 adult female 05day    25917 adult female 30day    24555 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (48736) embryo 02-04hr  (83257) embryo 04-06hr  (92038) embryo 06-08hr  (92575) embryo 08-10hr  (77290) embryo 10-12hr  (42946) embryo 12-14hr  (31002) embryo 14-16hr  (27027) embryo 16-18hr  (20341) embryo 18-20hr  (11245) embryo 20-22hr  (21867) embryo 22-24hr  (17066) larva L1  (9255) larva L2  (11172) larva L3 12hr old  (5828) larva L3 puffstage 1-2  (7915) larva L3 puffstage 3-6  (10904) larva L3 puffstage 7-9  (11712) white prepupae new  (12166) white prepupae 12hr  (13231) white prepupae 24hr  (15339) pupae 2d postWPP  (5593) pupae 3d postWPP  (2919) pupae 4d postWPP  (4421) adult male 01day  (2963) adult male 05day  (3717) adult male 30day  (3859) adult female 01day  (16410) adult female 05day  (25917) adult female 30day  (24555) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (48736) embryo 02-04hr  (83257) embryo 04-06hr  (92038) embryo 06-08hr  (92575) embryo 08-10hr  (77290) embryo 10-12hr  (42946) embryo 12-14hr  (31002) embryo 14-16hr  (27027) embryo 16-18hr  (20341) embryo 18-20hr  (11245) embryo 20-22hr  (21867) embryo 22-24hr  (17066) larva L1  (9255) larva L2  (11172) larva L3 12hr old  (5828) larva L3 puffstage 1-2  (7915) larva L3 puffstage 3-6  (10904) larva L3 puffstage 7-9  (11712) white prepupae new  (12166) white prepupae 12hr  (13231) white prepupae 24hr  (15339) pupae 2d postWPP  (5593) pupae 3d postWPP  (2919) pupae 4d postWPP  (4421) adult male 01day  (2963) adult male 05day  (3717) adult male 30day  (3859) adult female 01day  (16410) adult female 05day  (25917) adult female 30day  (24555) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (48736) embryo 02-04hr  (83257) embryo 04-06hr  (92038) embryo 06-08hr  (92575) embryo 08-10hr  (77290) embryo 10-12hr  (42946) embryo 12-14hr  (31002) embryo 14-16hr  (27027) embryo 16-18hr  (20341) embryo 18-20hr  (11245) embryo 20-22hr  (21867) embryo 22-24hr  (17066) larva L1    9255 larva L2  (11172) larva L3 12hr old    5828 larva L3 puffstage 1-2    7915 larva L3 puffstage 3-6  (10904) larva L3 puffstage 7-9  (11712) white prepupae new  (12166) white prepupae 12hr  (13231) white prepupae 24hr  (15339) pupae 2d postWPP    5593 pupae 3d postWPP    2919 pupae 4d postWPP    4421 adult male 01day    2963 adult male 05day    3717 adult male 30day    3859 adult female 01day  (16410) adult female 05day  (25917) adult female 30day  (24555) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    48736 embryo 02-04hr    83257 embryo 04-06hr    92038 embryo 06-08hr    92575 embryo 08-10hr    77290 embryo 10-12hr    42946 embryo 12-14hr    31002 embryo 14-16hr    27027 embryo 16-18hr    20341 embryo 18-20hr    11245 embryo 20-22hr    21867 embryo 22-24hr    17066 larva L1    9255 larva L2    11172 larva L3 12hr old    5828 larva L3 puffstage 1-2    7915 larva L3 puffstage 3-6    10904 larva L3 puffstage 7-9    11712 white prepupae new    12166 white prepupae 12hr    13231 white prepupae 24hr    15339 pupae 2d postWPP    5593 pupae 3d postWPP    2919 pupae 4d postWPP    4421 adult male 01day    2963 adult male 05day    3717 adult male 30day    3859 adult female 01day    16410 adult female 05day    25917 adult female 30day    24555 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0001197 expression level Developmental Stage   Expression Level embryo 00-02hr    48736 embryo 02-04hr    83257 embryo 04-06hr    92038 embryo 06-08hr    92575 embryo 08-10hr    77290 embryo 10-12hr    42946 embryo 12-14hr    31002 embryo 14-16hr    27027 embryo 16-18hr    20341 embryo 18-20hr    11245 embryo 20-22hr    21867 embryo 22-24hr    17066 larva L1    9255 larva L2    11172 larva L3 12hr old    5828 larva L3 puffstage 1-2    7915 larva L3 puffstage 3-6    10904 larva L3 puffstage 7-9    11712 white prepupae new    12166 white prepupae 12hr    13231 white prepupae 24hr    15339 pupae 2d postWPP    5593 pupae 3d postWPP    2919 pupae 4d postWPP    4421 adult male 01day    2963 adult male 05day    3717 adult male 30day    3859 adult female 01day    16410 adult female 05day    25917 adult female 30day    24555 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (48736) embryo 02-04hr  (83257) embryo 04-06hr  (92038) embryo 06-08hr  (92575) embryo 08-10hr  (77290) embryo 10-12hr  (42946) embryo 12-14hr  (31002) embryo 14-16hr  (27027) embryo 16-18hr  (20341) embryo 18-20hr  (11245) embryo 20-22hr  (21867) embryo 22-24hr  (17066) larva L1  (9255) larva L2  (11172) larva L3 12hr old  (5828) larva L3 puffstage 1-2  (7915) larva L3 puffstage 3-6  (10904) larva L3 puffstage 7-9  (11712) white prepupae new  (12166) white prepupae 12hr  (13231) white prepupae 24hr  (15339) pupae 2d postWPP  (5593) pupae 3d postWPP  (2919) pupae 4d postWPP  (4421) adult male 01day  (2963) adult male 05day  (3717) adult male 30day  (3859) adult female 01day  (16410) adult female 05day  (25917) adult female 30day  (24555) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (48736) embryo 02-04hr  (83257) embryo 04-06hr  (92038) embryo 06-08hr  (92575) embryo 08-10hr  (77290) embryo 10-12hr  (42946) embryo 12-14hr  (31002) embryo 14-16hr  (27027) embryo 16-18hr  (20341) embryo 18-20hr  (11245) embryo 20-22hr  (21867) embryo 22-24hr  (17066) larva L1  (9255) larva L2  (11172) larva L3 12hr old  (5828) larva L3 puffstage 1-2  (7915) larva L3 puffstage 3-6  (10904) larva L3 puffstage 7-9  (11712) white prepupae new  (12166) white prepupae 12hr  (13231) white prepupae 24hr  (15339) pupae 2d postWPP  (5593) pupae 3d postWPP  (2919) pupae 4d postWPP  (4421) adult male 01day  (2963) adult male 05day  (3717) adult male 30day  (3859) adult female 01day  (16410) adult female 05day  (25917) adult female 30day  (24555) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (48736) embryo 02-04hr  (83257) embryo 04-06hr  (92038) embryo 06-08hr  (92575) embryo 08-10hr  (77290) embryo 10-12hr  (42946) embryo 12-14hr  (31002) embryo 14-16hr  (27027) embryo 16-18hr  20341 embryo 18-20hr  11245 embryo 20-22hr  (21867) embryo 22-24hr  17066 larva L1    9255 larva L2  11172 larva L3 12hr old    5828 larva L3 puffstage 1-2    7915 larva L3 puffstage 3-6  10904 larva L3 puffstage 7-9  11712 white prepupae new  12166 white prepupae 12hr  13231 white prepupae 24hr  15339 pupae 2d postWPP    5593 pupae 3d postWPP    2919 pupae 4d postWPP    4421 adult male 01day    2963 adult male 05day    3717 adult male 30day    3859 adult female 01day  16410 adult female 05day  (25917) adult female 30day  (24555) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    48736 embryo 02-04hr    83257 embryo 04-06hr    92038 embryo 06-08hr    92575 embryo 08-10hr    77290 embryo 10-12hr    42946 embryo 12-14hr    31002 embryo 14-16hr    27027 embryo 16-18hr    20341 embryo 18-20hr    11245 embryo 20-22hr    21867 embryo 22-24hr    17066 larva L1    9255 larva L2    11172 larva L3 12hr old    5828 larva L3 puffstage 1-2    7915 larva L3 puffstage 3-6    10904 larva L3 puffstage 7-9    11712 white prepupae new    12166 white prepupae 12hr    13231 white prepupae 24hr    15339 pupae 2d postWPP    5593 pupae 3d postWPP    2919 pupae 4d postWPP    4421 adult male 01day    2963 adult male 05day    3717 adult male 30day    3859 adult female 01day    16410 adult female 05day    25917 adult female 30day    24555 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0001197    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0001197 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, larval hindgut, larval salivary gland, larval trachea, adult ovary, adult male reproductive system, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult thoracico-abdominal ganglion, adult crop, larval/adult midgut, adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, adult spermathecae, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0001197 expression level Tissue   Expression Level Larval Central Nervous System    2113.925 Larval Midgut    199.9 Larval Hindgut    540 Larval Malpighian Tubules    188.3 Larval Fat Body    229.5 Larval Salivary Gland    1670.6 Larval Trachea    1583.7 Larval Carcass    801.2 Adult Head    345.9 Adult Eye    555.325 Adult Brain    577.9 Adult Thoracic-Abdominal Ganglion    372.2 Adult Crop    272 Adult Midgut    333 Adult Hindgut    238 Adult Malpighian Tubules    247.9 Adult Fat Body    187.1 Adult Salivary Gland    242.7 Adult Heart    243.7 Adult VirginFemale Spermatheca    254.7 Adult InseminatedFemale Spermatheca    307.8 Adult Ovary    2182.6 Adult Testis    563.8 Adult Male Accessory Gland    501.9 Adult Carcass    185.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2113.925) Larval Midgut    199.9 Larval Hindgut  (540) Larval Malpighian Tubules    188.3 Larval Fat Body    229.5 Larval Salivary Gland  (1670.6) Larval Trachea  (1583.7) Larval Carcass  (801.2) Adult Head    345.9 Adult Eye  (555.325) Adult Brain  (577.9) Adult Thoracic-Abdominal Ganglion    372.2 Adult Crop    272 Adult Midgut    333 Adult Hindgut    238 Adult Malpighian Tubules    247.9 Adult Fat Body    187.1 Adult Salivary Gland    242.7 Adult Heart    243.7 Adult VirginFemale Spermatheca    254.7 Adult InseminatedFemale Spermatheca    307.8 Adult Ovary  (2182.6) Adult Testis  (563.8) Adult Male Accessory Gland  501.9 Adult Carcass    185.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2113.925) Larval Midgut    199.9 Larval Hindgut    540 Larval Malpighian Tubules    188.3 Larval Fat Body    229.5 Larval Salivary Gland  (1670.6) Larval Trachea  (1583.7) Larval Carcass    801.2 Adult Head    345.9 Adult Eye    555.325 Adult Brain    577.9 Adult Thoracic-Abdominal Ganglion    372.2 Adult Crop    272 Adult Midgut    333 Adult Hindgut    238 Adult Malpighian Tubules    247.9 Adult Fat Body    187.1 Adult Salivary Gland    242.7 Adult Heart    243.7 Adult VirginFemale Spermatheca    254.7 Adult InseminatedFemale Spermatheca    307.8 Adult Ovary  (2182.6) Adult Testis    563.8 Adult Male Accessory Gland    501.9 Adult Carcass    185.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2113.925 Larval Midgut    199.9 Larval Hindgut    540 Larval Malpighian Tubules    188.3 Larval Fat Body    229.5 Larval Salivary Gland    1670.6 Larval Trachea    1583.7 Larval Carcass    801.2 Adult Head    345.9 Adult Eye    555.325 Adult Brain    577.9 Adult Thoracic-Abdominal Ganglion    372.2 Adult Crop    272 Adult Midgut    333 Adult Hindgut    238 Adult Malpighian Tubules    247.9 Adult Fat Body    187.1 Adult Salivary Gland    242.7 Adult Heart    243.7 Adult VirginFemale Spermatheca    254.7 Adult InseminatedFemale Spermatheca    307.8 Adult Ovary    2182.6 Adult Testis    563.8 Adult Male Accessory Gland    501.9 Adult Carcass    185.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0001197 expression level Tissue   Expression Level Larval Central Nervous System    2113.925 Larval Midgut    199.9 Larval Hindgut    540 Larval Malpighian Tubules    188.3 Larval Fat Body    229.5 Larval Salivary Gland    1670.6 Larval Trachea    1583.7 Larval Carcass    801.2 Adult Head    345.9 Adult Eye    555.325 Adult Brain    577.9 Adult Thoracic-Abdominal Ganglion    372.2 Adult Crop    272 Adult Midgut    333 Adult Hindgut    238 Adult Malpighian Tubules    247.9 Adult Fat Body    187.1 Adult Salivary Gland    242.7 Adult Heart    243.7 Adult VirginFemale Spermatheca    254.7 Adult InseminatedFemale Spermatheca    307.8 Adult Ovary    2182.6 Adult Testis    563.8 Adult Male Accessory Gland    501.9 Adult Carcass    185.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2113.925) Larval Midgut    199.9 Larval Hindgut  540 Larval Malpighian Tubules    188.3 Larval Fat Body    229.5 Larval Salivary Gland  (1670.6) Larval Trachea  (1583.7) Larval Carcass  801.2 Adult Head    345.9 Adult Eye  555.325 Adult Brain  577.9 Adult Thoracic-Abdominal Ganglion    372.2 Adult Crop    272 Adult Midgut    333 Adult Hindgut    238 Adult Malpighian Tubules    247.9 Adult Fat Body    187.1 Adult Salivary Gland    242.7 Adult Heart    243.7 Adult VirginFemale Spermatheca    254.7 Adult InseminatedFemale Spermatheca    307.8 Adult Ovary  (2182.6) Adult Testis  563.8 Adult Male Accessory Gland  501.9 Adult Carcass    185.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2113.925) Larval Midgut    199.9 Larval Hindgut    540 Larval Malpighian Tubules    188.3 Larval Fat Body    229.5 Larval Salivary Gland  1670.6 Larval Trachea  1583.7 Larval Carcass    801.2 Adult Head    345.9 Adult Eye    555.325 Adult Brain    577.9 Adult Thoracic-Abdominal Ganglion    372.2 Adult Crop    272 Adult Midgut    333 Adult Hindgut    238 Adult Malpighian Tubules    247.9 Adult Fat Body    187.1 Adult Salivary Gland    242.7 Adult Heart    243.7 Adult VirginFemale Spermatheca    254.7 Adult InseminatedFemale Spermatheca    307.8 Adult Ovary  (2182.6) Adult Testis    563.8 Adult Male Accessory Gland    501.9 Adult Carcass    185.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2113.925 Larval Midgut    199.9 Larval Hindgut    540 Larval Malpighian Tubules    188.3 Larval Fat Body    229.5 Larval Salivary Gland    1670.6 Larval Trachea    1583.7 Larval Carcass    801.2 Adult Head    345.9 Adult Eye    555.325 Adult Brain    577.9 Adult Thoracic-Abdominal Ganglion    372.2 Adult Crop    272 Adult Midgut    333 Adult Hindgut    238 Adult Malpighian Tubules    247.9 Adult Fat Body    187.1 Adult Salivary Gland    242.7 Adult Heart    243.7 Adult VirginFemale Spermatheca    254.7 Adult InseminatedFemale Spermatheca    307.8 Adult Ovary    2182.6 Adult Testis    563.8 Adult Male Accessory Gland    501.9 Adult Carcass    185.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    345.9   NA  Eye    555.325   NA  Brain    577.9   2113.925  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    372.2   NA  Crop    272   199.9  Midgut    333   540  Hindgut    238   188.3  Malpighian Tubules    247.9   229.5  Fat Body    187.1   1670.6  Salivary Gland    242.7   NA  Heart    243.7   1583.7  Trachea    NA   NA  VirginFemale Spermatheca    254.7   NA  InseminatedFemale Spermatheca    307.8   NA  Ovary    2182.6   NA  Testis    563.8   NA  Male Accessory Gland    501.9   801.2  Carcass    185.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001197 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5499-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for His2Av Stages(s) 4-6 Stages(s) 7-8 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal His2Av810 His2AvCC00358 His2Avnm136 lethal, with Scer\GAL429BD His2AvGS3052 His2AvGS3127 lethal, with Scer\GAL4c355 His2AvGS3052 His2AvGS3127 lethal | larval stage His2Av810 lethal | larval stage | recessive His2Av810 lethal | recessive His2Av05146 His2AvL1602 His2Avn1 His2AvYD0140 semi-lethal His2Av05146 semi-lethal, with Scer\GAL4hs.2sev His2AvGS3127 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 His2AvGD4747 semi-lethal | recessive His2Av05146 viable His2Av72b Other Phenotypes Allele enhancer of variegation, with P{hsp26-pt-T}39C-3 His2Av810 suppressor of variegation, with P{hsp26-pt-T}118E-10 His2Av810 suppressor of variegation, with P{hsp26-pt-T}gw39C-33 His2Av810 suppressor of variegation | dominant His2Av810 suppressor of variegation | dominant, with In(1)wm4 His2Av810 visible, with Scer\GAL4dpp.blk1 His2AvGS3052 His2AvGS3127 visible, with Scer\GAL4hs.2sev His2AvGS3052 His2AvGS3127 visible, with Scer\GAL4pnr-MD237 His2AvGD4747 wild-type His2Av+t4.0 His2Av+t4.1 His2Av+tM5 His2AvT:Avic\GFP-S65T His2AvtCT Phenotype manifest in Allele anterior crossvein, with Scer\GAL4dpp.blk1 His2AvGS3052 eye, with Scer\GAL4hs.2sev His2AvGS3052 His2AvGS3127 mesothoracic tergum, with Scer\GAL4pnr-MD237 His2AvGD4747 tarsal segment, with Scer\GAL4dpp.blk1 His2AvGS3127
Classical Alleles ( 13 )
For All Classical Alleles Show
Allele of His2Av Class Mutagen Stocks Known lesion His2Av810 amorphic allele - genetic evidence ethyl methanesulfonate 1 Yes His2Av05146 P-element activity 1 -- His2AvEY04892 1 -- His2AvGS3052 Delta2-3 1 Yes His2Avn1 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- His2Av72b Delta2-3 0 Yes His2AvCC00358 P-element activity 0 Yes His2AvEP3641 P-element activity 0 -- His2AvG280 P-element activity 0 Yes His2AvGS3127 Delta2-3 0 Yes His2AvL1602 P-element activity 0 -- His2Avnm136 Delta2-3 0 Yes His2AvYD0140 piggyBac transposase 0 --
Alleles Carried on Transgenic Constructs ( 25 )
For All Alleles Carried on Transgenic Constructs Show
Allele of His2Av Class Mutagen Stocks Known lesion His2AvT:Avic\GFP-S65T in vitro construct - coding region fusion 6 Yes His2AvT:Disc\RFP-mRFP in vitro construct - coding region fusion in vitro construct - genomic fragment in vitro construct 6 Yes His2AvcCa.T:Avic\GFP-EGFP in vitro construct 1 Yes His2AvGD4747 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes His2AvHM05177 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes His2AvHMS00162 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes His2Av+t4.0 in vitro construct - genomic fragment 0 Yes His2Av+t4.1 in vitro construct - genomic fragment 0 Yes His2Av+tM5 in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes His2AvBole\ovo.T:Avic\GFP-YFP in vitro construct - regulatory fusion 0 Yes His2AvKK108652 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes His2Avovo.T:Avic\GFP-YFP in vitro construct - regulatory fusion 0 Yes His2AvScer\UAS.T:Avic\GFP-S65T in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes His2AvT:Avic\GFP-EGFP in vitro construct - coding region fusion 0 Yes His2AvT:Avic\GFP-PA in vitro construct - coding region fusion 0 Yes His2AvT:Disc\RFP in vitro construct - coding region fusion 0 Yes His2AvtCH322-97I07 in vitro construct - genomic fragment 0 Yes His2AvtCT in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes His2AvtM1 in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes His2AvtM2 in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes His2AvtM3 in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes His2AvtM4 in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes His2AvtM6 in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes His2AvtM7 in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes His2AvUbi-p63E.T:Avic\GFP-EYFP in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)BSC496 (Christensen et al., 2008.4.15) Df(3R)BSC524 (Christensen et al., 2008.6.11) Df(3R)ro80b (Kidd et al., 1999, Cook and Carpenter, 2002) Df(3R)ro-XB3 (Kidd et al., 1999, Knibb et al., 1993, Strutt and White, 1994, Yasuda et al., 1995) Df(3R)Tl-I (Cook and Carpenter, 2002) Df(3R)Tl-P (Spradling et al., 1999, Cook and Carpenter, 2002, BDGP Project Members, 1994-1999)
Not disrupted in	Df(3R)CC1.2 (Strutt and White, 1994) Df(3R)Espl3 (Cook and Carpenter, 2002) Df(3R)M1.1 (Strutt and White, 1994) Df(3R)ME61 (Cook and Carpenter, 2002) Df(3R)ms(3)K81-2 (Yasuda et al., 1995) Df(3R)ms(3)K81-3 (Yasuda et al., 1995) Df(3R)ms(3)K81-4 (Yasuda et al., 1995) Df(3R)ms(3)K81-5 (Yasuda et al., 1995) Df(3R)T2.1 (Strutt and White, 1994) Df(3R)Tl-X (Kidd et al., 1999, Cook and Carpenter, 2002) Df(3R)V2.1 (Strutt and White, 1994) Df(3R)X3.1 (Strutt and White, 1994)
Partially disrupted in	Df(3R)nm136 (Martinek et al., 2008)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4747} NA P{KK108652} NA P{TRiP.HM05177} NA P{TRiP.HMS00162} NA P{UAS-His2Av-GFP} NA characterization construct P{His2AvT:Avic\GFP-S65T} NA P{His2AvD} NA P{His2AvD+t4.0} NA P{His2AvD+tM5} NA P{His2AvDtCT} NA P{His2AvDtM1} NA P{His2AvDtM2} NA P{His2AvDtM3} NA P{His2AvDtM4} NA P{His2AvDtM6} NA P{His2AvDtM7} NA P{His2Av-EGFP.C} NA P{His2Av-EGFP} NA P{His2Av-mRFP1} NA P{His2Av-RFP.W} NA P{Ubi-p63E-His2avD.EYFP} NA PBac{CH322-97I07} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}His2AvL1602 No P{lacW}l(3)SH047SH047 No P{PZ}His2Av05146 No insertion of mobile activating element P{EP}His2AvEP3641 NA P{EPgy2}His2AvEY04892 NA P{GSV1}His2AvGS3052 NA P{GSV1}His2AvGS3127 NA miscellaneous insertions P{PTT-GC}His2AvCC00358 NA P{PTT-GC}His2AvG280 NA PBac{HpaI-GFP.A}His2AvYD0140 NA
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
response to DNA damage stimulus inferred from mutant phenotype (Ravi et al., 2009)
Cellular Component
CV term Evidence References
chromosome inferred from direct assay (Leach et al., 2000) lipid particle inferred from direct assay (Beller et al., 2006, Cermelli et al., 2006) nucleus inferred from direct assay (Leach et al., 2000) polytene chromosome inferred from direct assay (Leach et al., 2000)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
DNA binding inferred from electronic annotation with InterPro:IPR002119, InterPro:IPR007125, InterPro:IPR009072 (FlyBase Curators et al., 2004-) non-traceable author statement (Swiss-Prot Project Members, 1988.11.1)
Biological Process
CV term Evidence References
chromatin assembly or disassembly non-traceable author statement (Swiss-Prot Project Members, 1988.11.1) nucleosome assembly inferred from electronic annotation with InterPro:IPR002119 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
nucleosome inferred from electronic annotation with InterPro:IPR002119 (FlyBase Curators et al., 2004-) non-traceable author statement (Swiss-Prot Project Members, 1988.11.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions His2Av allele Gene References His2Av810 trx (Swaminathan et al., 2005) His2Av05146 os (Bach et al., 2003) trx (Swaminathan et al., 2005) unspecified pbl (Gregory et al., 2007) Pc (Swaminathan et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68120 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0001197 DroID - A comprehensive database of gene and protein interactions. • FBgn0001197 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43229
Orthologs
Genome-wide drosophilid orthologs	Dana\GF16458 Dere\GG11506 Dgri\GH10352 Dmoj\GI23052 Dper\GL27227 Dpse\GA18930 Dsec\GM10348 Dsim\GD21310 Dvir\GJ15170 Dwil\GK13546 Dyak\GE23696
Curated drosophilid orthologs	Dpse\GA18930
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL007609-PA Aedes aegypti (mosquito) AGAP000306-PA Anopheles gambiae (mosquito) XP_624167.1 Apis mellifera (honey bee) XP_001944895.1 Acyrthosiphon pisum (pea aphid) At3g54560.1 Arabidopsis thaliana (wall cress) 72473 Branchiostoma floridae (lancelet) 72478 Branchiostoma floridae (lancelet) BGIBMGA013449-PA Bombyx mori (silk worm) ENSBTAP00000022576 Bos taurus (bovine) CAL0004711 Candida albicans (a form of yeast) CN21826 Caenorhabditis brenneri (small nematode) CBP00449 Caenorhabditis briggsae (nematode) CE07426 Caenorhabditis elegans (worm) ENSCAFP00000015623 Canis familiaris (dog) CAGL0E02315g Candida glabrata (haploid yeast) Chro.50293 Cryptosporidium hominis (obligate parasite) ENSCINP00000011952 Ciona intestinalis (sea squirt) JA16704 Caenorhabditis japonica (nematode) CMR457C Cyanidioschyzon merolae (red alga) cn09269 Cryptococcus neoformans (yeast-like fungus) cgd5_940 Cryptosporidium parvum (protozoan parasite) CPIJ008494 Culex pipens (mosquito) ENSCPOP00000000687 Cavia porcellus (guinea pig) 187884 Chlamidomonas reinhardtii (green alga) RP13860 Caenorhabditis remanei (nematode) ENSCSAVP00000015497 Ciona savignyi (sedentary tunicate) 170341 Capitella spl (polychaete worm) DDB0216302 Dictyostelium discoideum (amoeba) DEHA2E05720g Debaryomyces Hansenii (yeast) 300571 Daphnia pulex (daphnia) ENSDARP00000068975 Danio rerio (zebra fish) ENSDARP00000090434 Danio rerio (zebra fish) ENSECAP00000014243 Equus caballus (horse) ENSGACP00000019299 Gymnopilus aculeatus (mushroom) ENSGALP00000028277 Gallus gallus (chicken) 157365 Hypsipyla robusta (cedar shoot borer) ENSP00000308405 Homo sapiens (human) KLLA0C05918g Kluyveromyces lactis (yeast) 156627 Lottia gigantea (owl limpet) LmjF17.0280 Leishmania major (virus) ENSMODP00000020077 Monodelphis domestica (gray opossum) ENSMMUP00000006168 Macaca mulatta (rhesus monkey) ENSMUSP00000036907 Mus musculus (house mouse) 180812 Nematostella vectensis (starlet anemone) XP_001605065.1 Nasonia vitripennis (wasp) ENSOANP00000014916 Ornithorynchus anatinus (platypus) ENSORLP00000015255 Oryzias latipes (japanese killifish) LOC_Os03g06670.1 Oryza sativa (asian rice) 8126 Ostreococcus tauri (green alga) PFC0920w Plasmodium falciparum (protozoal parasite) PHUM001526-PA Pediculus humanus (human body louse) 144787 Physcomitrella patens (moss) 226746 Physcomitrella patens (moss) ENSPPYP00000019708 Pongo pygmaeus (orangutan) 45574 Phytophthora ramorum (sudden oak death pathogen) 710129 Populus trichocarpa (black cottonwood) ENSPTRP00000028020 Pan troglodytes (chimpanzee) PVX_095190 Plasmodium vivax (protozoal parasite) ENSRNOP00000013919 Rattus norvegicus (norway rat) ENSRNOP00000045180 Rattus norvegicus (norway rat) 144529 Sorghum bicolor (sorghum) YOL012C Saccharomyces cerevisiae (budding yeast) SPBC11B10.10c Schizosaccharomyces pombe (fission yeast) XP_001176112.1 Strongylocentrotus purpuratus (purple sea urchin) 35819 Trichoplax adhaerens (metazoa) TA14155 Theileria annulata (apicomplexan parasite) XP_975468.1 Tribolium castaneum (red flour beetle) Tc00.1047053511323.40 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000018703 Tetraodon nigroviridis (green spotted pufferfish) TP02_0611 Theileria parva (parasitic protozoan) 268117 Thalassiosira pseudonana (marine diatom) ENSTRUP00000040984 Takifugu rubripes (pufferfish Takifugu) 3702.m00093 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000002709 Xenopus tropicalis (frog) YALI0F02827g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV16472 LH24911 ISCW004473 FBgn0240855 FBgn0215554 FBgn0202367 FBgn0192748 FBgn0165299 JGI_V11_300571 FBgn0078929 FBgn0164808 FBgn0145779 FBgn0117833 FBgn0103804 FBgn0097266 FBgn0093479 CPIJ008494 BGIBMGA013449 ACYPI005340 GB12991 AGAP000306 AAEL015390 AAEL007609 PHUM368550 GLEAN_00931
Stocks & Reagents
Stocks Listed in FlyBase ( 19 )
Bloomington	23651 w*; P{His2Av-mRFP1}II.2 23650 w*; P{His2Av-mRFP1}III.1 24163 w*; P{His2Av-EGFP.C}2/SM6a 28966 y1 v1; P{TRiP.HM05177}attP2 9264 w*; His2Av810/TM3, Sb1 5941 w1118; P{His2AvT:Avic\GFP-S65T}62A 25377 w*; P{Hsp83-GFP.lacI}2, P{His2Av-mRFP1}II.1 34498 w1118; P{His2Av-mRFP1}III.1 P{FRT(whs)}2A 34499 w1118; P{His2Av-mRFP1}III.1 P{neoFRT}80B/TM6B, Tb1 34844 y1 sc* v1; P{TRiP.HMS00162}attP2/TM3, Sb1
Kyoto	108494 w1118; P{His2AvT:Avic\GFP-S65T}62A
VDRC	v12768 w1118; P{GD4747}v12768
	More stocks available...
Genomic Clones ( 1 )
	BACR24O14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 166 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD21568
Other clones	DPiM_LD21568
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH15210 GH21178 GM05050 GM07879 GM09014 LD02533 LD06266 LD13419 LD15832 LD17837 LD17953 LD18591 LD25923 LD26003 LD27562 LD27752 LD28243 LD29456 LD33538 LD33886 LD38125 LD38160 LD40570 LD44612 LP03192 LP04992 LP07551 LP09903 RE04552 RE07048 RE11158 RE11701 RE12360 RE12808 RE14819 RE15516 RE18623 RE21650 RE22024 RE24490 RE25672 RE27308 RE28813 RE28874 RE28940 RE32954 RE33318 RE35205 RE35490 RE36665 RE41886 RE42689 RE46071 RE52247 RE53693 RE54009 RE54089 RE54501 RE54648 RE62030 RE66203 RE68735 RE68943 RE69745 RE70206 SD10195 SD13081 SD14657 SD21928
Other clones	1747 11674 11791 15397 20854 33729 59142 63901 76041 76190 78418 78460 79526 79678 82172 97531 101514 105808 173549 174299 176358 214317.8 274570 533804 542768 CK01.22B.F1 CK01.64B.H1 Dmel_dig_003874_0683_3551 Dmel_dig_004023_0681_1091 Dmel_dig_008073_0697_0288 Dmel_dig_009095_0613_0701 Dmel_dig_009707_0632_2732 Dmel_dig_011638_0649_0747 Dmel_dig_017980_0587_1551 Dmel_dig_019134_0584_2939 Dmel_dig_019588_0684_1967 Dmel_dig_020204_0594_0800 Dmel_neb_003824_0636_1253 Dmel_neb_007790_0654_0657 Dmel_neb_014175_0906_0839 EC00759 EK043840 EK052222 EK065029 EK112158 EK123143 EK154202 EK189554 EK198407 EK204406 EK207618 EK209346 EK209416 EK215610 EK220228 EK227929 EK230915 EK256101 EK281249 EK302011 EN10212 EP15844 FGC019D12 FGC023D10 FGC031B08 FGH104E02 FGH105A02 FGH118C03 FGH126F11 FGM230G07 FGM235C09 FGM312A08 FGM320C01 IP11757 RP003020193 RP003155167 RP003164854 RP003165600 RP003252342 RP003257419 RP003259290 RP003277955 RP003301260 RP003335485 RP003350359 RP003356560 RP003425799 RP003478100 RP003565038 RP003646259 RP003651162 RP003654725 RP003671396 UUGC0404 UUGC0664
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0001197 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43229
Antibody Information
	polyclonal (van Daal and Elgin, 1992, Mehrotra and McKim, 2006, Madigan et al., 2002, Lancaster et al., 2010)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: His2Av l(3)05146 (Spradling et al., 1999)
Additional comments
Other Comments
	The C terminal region of His2Av, excluding the last 12 amino acids, is critical for function. This region is buried inside the histone core and is not responsible for interactions with DNA, but is possibly involved in protein-protein interactions. (Clarkson et al., 1999) In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes. (Kliman and Eyre-Walker, 1998) His2Av function is essential for nucleosome assembly and is continuously expressed. (van Daal and Elgin, 1992) His2Av has been cloned and sequenced. (van Daal et al., 1990) Isolated from a cDNA library, using a Tetrahymena histone H2A variant hv1 cDNA as a probe. (van Daal et al., 1988) A His2Av cDNA has been cloned and sequenced. (van Daal et al., 1988)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079795 RefSeq (Proteins) • NP_524519 DDBJ / EMBL / GenBank • AA441058 AA735581 AAB22897 AAF56631 AAM50770 AI455166 AQ026206 AQ026244 AQ073083 AY118910 CAA30370 CAA33555 S42733 X07485 X15549 Entrez Gene - A searchable database of RefSeq genes. • 43229 UniProtKB/Swiss-Prot • P08985
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Histone H2A (IPR002119) Histone core (IPR007125) Histone-fold (IPR009072)
Linkouts
	BioGRID - A database of protein and genetic interactions • 68120 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0001197 DroID - A comprehensive database of gene and protein interactions. • FBgn0001197 DRSC - Results from RNAi screens. • FBgn0001197 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001197 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5499-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0001197 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43229 InParanoid A subset of ortholog calls from InParanoid. • AAEL007609-PA Aedes aegypti (mosquito) AGAP000306-PA Anopheles gambiae (mosquito) XP_624167.1 Apis mellifera (honey bee) XP_001944895.1 Acyrthosiphon pisum (pea aphid) At3g54560.1 Arabidopsis thaliana (wall cress) 72473 Branchiostoma floridae (lancelet) 72478 Branchiostoma floridae (lancelet) BGIBMGA013449-PA Bombyx mori (silk worm) ENSBTAP00000022576 Bos taurus (bovine) CAL0004711 Candida albicans (a form of yeast) CN21826 Caenorhabditis brenneri (small nematode) CBP00449 Caenorhabditis briggsae (nematode) CE07426 Caenorhabditis elegans (worm) ENSCAFP00000015623 Canis familiaris (dog) CAGL0E02315g Candida glabrata (haploid yeast) Chro.50293 Cryptosporidium hominis (obligate parasite) ENSCINP00000011952 Ciona intestinalis (sea squirt) JA16704 Caenorhabditis japonica (nematode) CMR457C Cyanidioschyzon merolae (red alga) cn09269 Cryptococcus neoformans (yeast-like fungus) cgd5_940 Cryptosporidium parvum (protozoan parasite) CPIJ008494 Culex pipens (mosquito) ENSCPOP00000000687 Cavia porcellus (guinea pig) 187884 Chlamidomonas reinhardtii (green alga) RP13860 Caenorhabditis remanei (nematode) ENSCSAVP00000015497 Ciona savignyi (sedentary tunicate) 170341 Capitella spl (polychaete worm) DDB0216302 Dictyostelium discoideum (amoeba) DEHA2E05720g Debaryomyces Hansenii (yeast) 300571 Daphnia pulex (daphnia) ENSDARP00000068975 Danio rerio (zebra fish) ENSDARP00000090434 Danio rerio (zebra fish) ENSECAP00000014243 Equus caballus (horse) ENSGACP00000019299 Gymnopilus aculeatus (mushroom) ENSGALP00000028277 Gallus gallus (chicken) 157365 Hypsipyla robusta (cedar shoot borer) ENSP00000308405 Homo sapiens (human) KLLA0C05918g Kluyveromyces lactis (yeast) 156627 Lottia gigantea (owl limpet) LmjF17.0280 Leishmania major (virus) ENSMODP00000020077 Monodelphis domestica (gray opossum) ENSMMUP00000006168 Macaca mulatta (rhesus monkey) ENSMUSP00000036907 Mus musculus (house mouse) 180812 Nematostella vectensis (starlet anemone) XP_001605065.1 Nasonia vitripennis (wasp) ENSOANP00000014916 Ornithorynchus anatinus (platypus) ENSORLP00000015255 Oryzias latipes (japanese killifish) LOC_Os03g06670.1 Oryza sativa (asian rice) 8126 Ostreococcus tauri (green alga) PFC0920w Plasmodium falciparum (protozoal parasite) PHUM001526-PA Pediculus humanus (human body louse) 144787 Physcomitrella patens (moss) 226746 Physcomitrella patens (moss) ENSPPYP00000019708 Pongo pygmaeus (orangutan) 45574 Phytophthora ramorum (sudden oak death pathogen) 710129 Populus trichocarpa (black cottonwood) ENSPTRP00000028020 Pan troglodytes (chimpanzee) PVX_095190 Plasmodium vivax (protozoal parasite) ENSRNOP00000013919 Rattus norvegicus (norway rat) ENSRNOP00000045180 Rattus norvegicus (norway rat) 144529 Sorghum bicolor (sorghum) YOL012C Saccharomyces cerevisiae (budding yeast) SPBC11B10.10c Schizosaccharomyces pombe (fission yeast) XP_001176112.1 Strongylocentrotus purpuratus (purple sea urchin) 35819 Trichoplax adhaerens (metazoa) TA14155 Theileria annulata (apicomplexan parasite) XP_975468.1 Tribolium castaneum (red flour beetle) Tc00.1047053511323.40 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000018703 Tetraodon nigroviridis (green spotted pufferfish) TP02_0611 Theileria parva (parasitic protozoan) 268117 Thalassiosira pseudonana (marine diatom) ENSTRUP00000040984 Takifugu rubripes (pufferfish Takifugu) 3702.m00093 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000002709 Xenopus tropicalis (frog) YALI0F02827g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /polycomb/histoneh2av-1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43229 modMine - Data generated by the modENCODE project. • FBgn0001197 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV16472 LH24911 ISCW004473 FBgn0240855 FBgn0215554 FBgn0202367 FBgn0192748 FBgn0165299 JGI_V11_300571 FBgn0078929 FBgn0164808 FBgn0145779 FBgn0117833 FBgn0103804 FBgn0097266 FBgn0093479 CPIJ008494 BGIBMGA013449 ACYPI005340 GB12991 AGAP000306 AAEL015390 AAEL007609 PHUM368550 GLEAN_00931
Synonyms & Secondary IDs ( 45 )
Reported As
Symbol Synonym	5499 (Ravi et al., 2009) CG5499 (Kusch et al., 2004, Rebollo et al., 2004, Laviolette et al., 2005, Cermelli et al., 2006, Wagner et al., 2007, Quinones-Coello, 2007, Quinones-Coello, 2007, Perkins et al., 2009, Keleman et al., 2009.8.5, Ni et al., 2011.7.19, Cammarato et al., 2011) H2A (Wang et al., 2011) H2A.F/Z (Zhu et al., 2007) H2a.V (Wagner et al., 2007) H2A.X   H2A.Z (Raisner, 2006, Varga-Weisz, 2006, Lippman and Martienssen, 2004, Mavrich et al., 2008, Frydrychova et al., 2008, Cui and Zhurkin, 2009, Rach et al., 2011, Weber et al., 2010, Egelhofer et al., 2011) H2Av (Henikoff et al., 2009, Polo, 2006, Ivanovska et al., 2005, Heeger et al., 2005, Webber et al., 2004, Kusch et al., 2004, Kusch et al., 2004, Kusch et al., 2004, Madigan et al., 2002, Glaser et al., 2002, Leach et al., 2000, Tulin et al., 2007, Langley and Karpen, 2007, Klattenhoff et al., 2007, Oikemus et al., 2007, Cermelli et al., 2006, Jin, 2005, Wagner et al., 2007, Haynes et al., 2007, Sakaguchi and Steward, 2007, Takada et al., 2007, Zhang and Pugh, 2011, Yan et al., 2011, Brasaemle and Hansen, 2006, Zhang and Karpen, 2008, Langley and Karpen, 2008, Wagner et al., 2007, Lu et al., 2007, Hong et al., 2007, Johansson et al., 2007, Pauli et al., 2008, Mavrich et al., 2008, Royou et al., 2008, Pandey et al., 2007, Martinek et al., 2008, McCleland et al., 2009, Narbonne-Reveau and Lilly, 2009, Peng and Karpen, 2009, Dronamraju and Mason, 2009, Nie et al., 2009, Hanai et al., 2008, Macalpine et al., 2010, Deal et al., 2010, Huang et al., 2010, Pinnola et al., 2007, Schittenhelm et al., 2010, Andreyeva et al., 2008, Kriston-Vizi et al., 2011, Weber et al., 2010, Bryson et al., 2010) H2AV (Bandura, 2005, Garcia et al., 2007, Purdy et al., 2005, Mehrotra et al., 2008, Klovstad et al., 2008, Sakai et al., 2009) H2av (Lam et al., 2005) H2AV_DROM (Storm and Sonnhammer, 2003) H2AvD (Kamakaka, 2005, Redon et al., 2002, van Daal, 1992.10.26, Rogakou et al., 1999, Spradling et al., 1999, Strutt and White, 1994, Clarkson et al., 1994, van Daal and Elgin, 1992, van Daal et al., 1990, Elgin and van Daal, 1990, van Daal et al., 1988, Tanabe et al., 2008, Corona et al., 2007, Pandey et al., 2005, Rathke et al., 2007, Vardanyan et al., 2008, Bosveld et al., 2008, Bosveld et al., 2008, Siriaco et al., 2009, Lerit and Gavis, 2011, Matsuda et al., 2010) H2avD (Manak et al., 2007, Wen et al., 2008) h2AvD (Rong, 2008, Gao et al., 2009) H2AX (Klattenhoff et al., 2007, Yan et al., 2011, Klattenhoff et al., 2009) H2AZ (Redon et al., 2002, ) his (Pokrywka et al., 2009) His2 (Ninov et al., 2010) His2Av (Beller et al., 2006, Dudu, 2006, Laviolette et al., 2005, Dudu et al., 2006, Gregory et al., 2007, Heidmann, 2007.2, Langille and Clark, 2007, Schubiger, 2007.9.19, Schuh et al., 2007, Raja and Renkawitz-Pohl, 2005, Schuh et al., 2007, Buszczak et al., 2007, Quinones-Coello, 2007, Lott et al., 2011, Christensen et al., 2008.4.15, Christensen et al., 2008.6.11, Lake et al., 2007, Mehrotra and McKim, 2006, Dorus et al., 2006, Maurange et al., 2008, Zhong and Belote, 2007, Jang et al., 2003, Baldinger and Gossen, 2009, Pauli et al., 2008, Bischoff and Cseresnyés, 2009, Venken et al., 2009, Hanai et al., 2008, Little et al., 2011, Kuranaga et al., 2011, Taliaferro et al., 2011, Abreu-Blanco et al., 2011, Nakayama et al., 2009, Lake et al., 2011) HIS2AV (McCaffrey et al., 2006, Joyce and McKim, 2009, Joyce et al., 2009) His2AV (Blumenstiel et al., 2009) His2AvD (Haigh, 2005, Post and Arndt-Jovin, 2003, Heidmann et al., 2004, Saint and Clarkson, 2000, Kidd et al., 1999, Clarkson et al., 1999, Clarkson and Saint, 1999, Toba et al., 1999, Kliman and Eyre-Walker, 1998, Lindsley and Zimm, 1992, Crest et al., 2007, Barry et al., 2011, Lee et al., 2006, Savoian and Rieder, 2002, Siller et al., 2005, da Silva and Vincent, 2007, Dyer et al., 2007, Katsani et al., 2008, Pandey et al., 2005, Wen et al., 2008, Schittenhelm et al., 2009, Orsi et al., 2010, Venkei et al., 2011) HIS2AVD (Staudt et al., 2006) HisH2Av (Quinones-Coello, 2007) Hist (Coppey et al., 2008, Tipping et al., 2010) Hist2av (Parma et al., 2007) l(3)97Dd (Yasuda et al., 1995, Knibb et al., 1993) l(3)810   l(3)05146 (Berkeley Drosophila Genome Project, 1993.6.1, Kidd et al., 1999, Meister and Braun, 1995.10, BDGP Project Members, 1994-1999, ) l(3)L1602 (Beaton, 2000.1.31) γ-H2Av (Klattenhoff et al., 2009) γH2Av (Lancaster et al., 2010) γ-His2Av (Mehrotra and McKim, 2006, Peretz et al., 2009) γ-HIS2AV (Gong et al., 2005)
Name Synonym	H2A variant (D and Emerson, 2006) histone (Frydman et al., 2006, Yu et al., 2006, Savoian and Rieder, 2002, McCleland et al., 2009, McCleland and O'Farrell, 2008, Coppey et al., 2008, Wang et al., 2010, Puah et al., 2011) histone2A (Skold et al., 2005) Histone-2A (Taliaferro et al., 2011) Histone2Av (Kuranaga et al., 2011) histone 2A variant (Schuh et al., 2007) histone2AvD (Schneider et al., 2006) histone H2Av (Pandey et al., 2007, Kondo and Perrimon, 2011) Histone H2A variant (Cammarato et al., 2011) histone H2A variant (Cermelli et al., 2006, Pandey et al., 2007) histone variant H2Av (Bulchand et al., 2010)
Secondary FlyBase IDs
	FBgn0010859
References ( 247 )
Generate a list of	All references relating to this gene ( 247 )
List References by type	Research paper  ( 177 ) Supplementary material  ( 17 ) Review  ( 11 ) Personal communication to FlyBase  ( 13 ) Abstract  ( 16 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Letter  ( 1 ) Computer file  ( 3 ) Book  ( 1 ) Conference report  ( 1 ) Protein sequence record  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 31 )
	Abreu-Blanco et al., 2011, J. Cell Biol. 193(3): 455--464 Cell wound repair in Drosophila occurs through three distinct phases of membrane and cytoskeletal remodeling. [FBrf0213583] Barry et al., 2011, Development 138(9): 1759--1769 The Drosophila STUbL protein Degringolade limits HES functions during embryogenesis. [FBrf0213458] Egelhofer et al., 2011, Nat. Struct. Mol. Biol. 18(1): 91--93 An assessment of histone-modification antibody quality. [FBrf0212707] Gibson et al., 2011, Cell 144(3): 427--438 Control of the mitotic cleavage plane by local epithelial topology. [FBrf0214365] Kondo and Perrimon, 2011, Sci. Signal. 4(154): rs1 A Genome-Wide RNAi Screen Identifies Core Components of the G2-M DNA Damage Checkpoint. [FBrf0212700] Kriston-Vizi et al., 2011, BMC Bioinformatics 12: 232 Gebiss: an ImageJ plugin for the specification of ground truth and the performance evaluation of 3d segmentation algorithms. [FBrf0214312] Kuranaga et al., 2011, Development 138(8): 1493--1499 Apoptosis controls the speed of looping morphogenesis in Drosophila male terminalia. [FBrf0213320] Lake et al., 2011, PLoS Genet. 7(2): e1002005 The Drosophila zinc finger protein trade embargo is required for double strand break formation in meiosis. [FBrf0213142] Lerit and Gavis, 2011, Curr. Biol. 21(6): 439--448 Transport of germ plasm on astral microtubules directs germ cell development in Drosophila. [FBrf0213255] Little et al., 2011, PLoS Biol. 9(3): e1000596 The formation of the bicoid morphogen gradient requires protein movement from anteriorly localized mRNA. [FBrf0213215] Lott et al., 2011, PLoS Biol. 9(2): e1000590 Noncanonical Compensation of Zygotic X Transcription in Early Drosophila melanogaster Development Revealed through Single-Embryo RNA-Seq. [FBrf0213135] Puah et al., 2011, BioTechniques 51(1): 49--54 TLM-Converter: reorganization of long time-lapse microscopy datasets for downstream image analysis. [FBrf0214451] Rach et al., 2011, PLoS Genet. 7(1): e1001274 Transcription initiation patterns indicate divergent strategies for gene regulation at the chromatin level. [FBrf0214353] Taliaferro et al., 2011, Genes Dev. 25(6): 608--620 Evolution of a tissue-specific splicing network. [FBrf0213285] Venkei et al., 2011, Genetics 187(1): 131--140 Drosophila mis12 complex acts as a single functional unit essential for anaphase chromosome movement and a robust spindle assembly checkpoint. [FBrf0212773] Wang et al., 2011, PLoS Genet. 7(8): e1002227 PP2A-Twins Is Antagonized by Greatwall and Collaborates with Polo for Cell Cycle Progression and Centrosome Attachment to Nuclei in Drosophila Embryos. [FBrf0214683] Yan et al., 2011, FASEB J. 25(1): 232--241 Unphosphorylated STAT and heterochromatin protect genome stability. [FBrf0212715] Zhang and Pugh, 2011, PLoS ONE 6(6): e20511 Genomic Organization of H2Av Containing Nucleosomes in Drosophila Heterochromatin. [FBrf0214284] Bryson et al., 2010, Fly 4(3): 258--265 Baculovirus-encoded protein expression for epigenomic profiling in Drosophila cells. [FBrf0216359] Bulchand et al., 2010, J. Cell Sci. 123(16): 2697--2707 Muscle wasted: a novel component of the Drosophila histone locus body required for muscle integrity. [FBrf0211459] Deal et al., 2010, Science 328(5982): 1161--1164 Genome-wide kinetics of nucleosome turnover determined by metabolic labeling of histones. [FBrf0210910] Huang et al., 2010, J. Cell Sci. 123(16): 2853--2861 Drosophila CAF-1 regulates HP1-mediated epigenetic silencing and pericentric heterochromatin stability. [FBrf0211452] Lancaster et al., 2010, PLoS Genet. 6(10): e1001179 The Meiotic Recombination Checkpoint Suppresses NHK-1 Kinase to Prevent Reorganisation of the Oocyte Nucleus in Drosophila. [FBrf0212208] Macalpine et al., 2010, Genome Res. 20(2): 201--211 Drosophila ORC localizes to open chromatin and marks sites of cohesin complex loading. [FBrf0209851] Matsuda et al., 2010, PLoS ONE 5(9): e12768 Condensed Mitotic Chromosome Structure at Nanometer Resolution Using PALM and EGFP- Histones. [FBrf0211844] Ninov et al., 2010, Curr. Biol. 20(6): 513--520 Dpp signaling directs cell motility and invasiveness during epithelial morphogenesis. [FBrf0210385] Orsi et al., 2010, J. Cell Sci. 123(20): 3515--3524 Drosophila I-R hybrid dysgenesis is associated with catastrophic meiosis and abnormal zygote formation. [FBrf0212012] Schittenhelm et al., 2010, J. Cell Sci. 123(21): 3768--3779 Detrimental incorporation of excess Cenp-A/Cid and Cenp-C into Drosophila centromeres is prevented by limiting amounts of the bridging factor Cal1. [FBrf0212150] Tipping et al., 2010, EMBO J. 29(19): 3222--3235 β-arrestin Kurtz inhibits MAPK and Toll signalling in Drosophila development. [FBrf0211995] Wang et al., 2010, Cytoskeleton (Hoboken) 67(11): 715--728 Coupling between microtubule sliding, plus-end growth and spindle length revealed by kinesin-8 depletion. [FBrf0212142] Weber et al., 2010, Nat. Struct. Mol. Biol. 17(12): 1500--1507 H2A.Z nucleosomes enriched over active genes are homotypic. [FBrf0212462] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...