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General Information
Symbol
Dmel\Hn
Species
D. melanogaster
Name
Henna
Annotation Symbol
CG7399
Feature Type
FlyBase ID
FBgn0001208
Gene Model Status
Stock Availability
Enzyme Name (EC)
Phenylalanine 4-monooxygenase (1.14.16.1)
Gene Snapshot
Henna (Hn) encodes a tryptophan phenylalanine hydroxylase. It is a dual function enzyme: it hydroxylates both phenylalanine to generate tyrosine, as well as tryptophan to generate the precursor for peripheral (non-neuronal) serotonin. It is also involved in pteridine synthesis. [Date last reviewed: 2019-03-07]
Also Known As

DTPH, Pah, TPH, phenylalanine hydroxylase, DTPHu

Key Links
Genomic Location
Cytogenetic map
Sequence location
3L:7,760,453..7,763,166 [+]
Recombination map

3-21

RefSeq locus
NT_037436 REGION:7760453..7763166
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (7 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
inferred from direct assay
inferred from mutant phenotype
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from electronic annotation with InterPro:IPR001273, InterPro:IPR018301
(assigned by InterPro )
inferred from biological aspect of ancestor with PANTHER:PTN000895564
(assigned by GO_Central )
Biological Process (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
inferred from genetic interaction with FLYBASE:Ddc; FB:FBgn0000422
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000895564
(assigned by GO_Central )
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Protein Family (UniProt)
Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. (P17276)
Catalytic Activity (EC)
Experimental Evidence
L-phenylalanine + tetrahydrobiopterin + O(2) = L-tyrosine + 4a-hydroxytetrahydrobiopterin (1.14.16.1)
Predictions / Assertions
L-phenylalanine + tetrahydrobiopterin + O(2) = L-tyrosine + 4a-hydroxytetrahydrobiopterin (1.14.16.1)
Summaries
Gene Group (FlyBase)
PAIRED DONOR OXIDOREDUCTASES, INCORPORATION OF MOLECULAR OXYGEN, PTERIDINE AS DONOR -
Paired donor oxidoreductases, incorporation of molecular oxygen, pteridine as donor include, dehydrogenases that catalyze an oxidation-reduction reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor.
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
Hn: Henna
A recessive eye color mutant, amorphic alleles of which show slight dominance. The first allele described, being associated with a deficiency, was homozygous lethal, and therefore only the slight dominant phenotype of homogenously dark, dull brown eye color could be scored; thus the dominant symbol Hn was applied. All subsequent alleles homozygous viable, exhibiting dark brown sepia-like or clot-like eyecolor in homozygous flies. Red pteridine eye pigments, drosopterins, reduced and sepiapterin accumulates; sepiapterin reductase levels reduced (Barthelmess and Robertson, 1970, Genet. Res. 15: 65-86). Eye color of Hnr and Hnr3 autonomous in transplants of optic disk into wild-type hosts (Beadle and Ephrussi, 1936, Genetics 21: 230). Larval Malpighian tubes bright yellow as in wild type (Beadle, 1937, Genetics 22: 587-611). RK1 or 2 as homozygote.
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
3

Please see the JBrowse view of Dmel\Hn for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0076811
1625
452
FBtr0100225
1617
447
FBtr0334645
1527
452
FBtr0334646
1821
178
Additional Transcript Data and Comments
Reported size (kB)

1.75 (northern blot)

1.5 (northern blot)

Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0076523
51.7
452
5.66
FBpp0099602
51.0
447
5.49
FBpp0306707
51.7
452
5.66
FBpp0306708
20.1
178
4.34
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

452 aa isoforms: Hn-PA, Hn-PC
Additional Polypeptide Data and Comments
Reported size (kDa)

453 (aa); 50 (kD observed)

50-52 (kD observed); 50-52 (kD)

Comments
External Data
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hn using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

The Hn transcript is present in the adult head and body, and in early embryos. The transcript localizes to the fat body in third instar larval sections, and is also detected in the mouthparts and cuticle. Embryonic Hn transcript is ubiquitous, and appears to be concentrated in yolk granules.

Hn transcript is detected at low levels in 0-12 hr embryos and at high levels in 12-24 hr embryos and in larval stages. Hn transcript is expressed at high levels in the larval fat body.

Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

Hn is expressed ubiquitously in early embryos. It is expressed in cells surrounding invaginating tissues in 2--6-hour embryos. Later it is expressed in fat body and in a subset of neuroblasts. Expression is restricted to dopaminergic neurons.

The Hn protein is present in larval and pupal stages, as well as in the adult head. A 50 kD Hn protein is detected starting in 12-18 hr embryos, and persists through pupal and larval stages, and in adult heads. An additional 45 kD protein is detected in early embryos and in female abdomens. Immunolocalization to central nervous systems dissected from different larval stages stains distinct neurons in the ventral ganglia and brain lobes. Pairs of ventral lateral neurons staining with Hn protein match the position of serotonin-pos tive neurons. The position of dorsolateral neurons in the abdominal neuromeres and medial unpaired neurons staining with Hn match the position of catecholamine-positive neurons. In 0-6 hr embryos, Hn protein is detected in yolk granules.

An antibody against monkey liver phenylalanine hydroxylase cross reacts with a Drosophila protein present in samples from third instar larvae to adult. The strongest signal was seen at pupation with a secondary peak at the end of the pupal stage. Levels quickly decrease in the adult. The protein was also studied in isolated tissues and was detected in 3rd instar larval fat body and in the adult head. Reduced enzyme activity and CRM are observed in Hn(r) and Hn(r3) mutants.

Hn protein is detected from late third instar larval to early adult stages, with highest levels at pupariation and a smaller peak at the end of the pupal stage. In dissected third instar larval tissue, only the fat body showed expression of Hn protein. In young adult flies, expression was detected in the head.

Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
Reporter: P{Hn.493-Gal4}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{Hn.819-Gal4}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{Hn.996-Gal4}
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Hn in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 13-16
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 18 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Hn
Transgenic constructs containing regulatory region of Hn
Deletions and Duplications ( 9 )
Phenotypes
Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
14 of 15
Yes
Yes
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
14 of 15
Yes
Yes
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (4)
12 of 13
Yes
Yes
2 of 13
No
No
2 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (4)
12 of 12
Yes
Yes
2 of 12
No
No
1 of 12
No
No
1 of 12
No
No
Danio rerio (Zebrafish) (6)
13 of 15
Yes
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (3)
14 of 15
Yes
Yes
3 of 15
No
No
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919070D )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150515 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0403 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X054P )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G05MZ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (2)
4 of 10
3 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map

    3-21

    Cytogenetic map
    Sequence location
    3L:7,760,453..7,763,166 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    66A12-66A12
    Limits computationally determined from genome sequence between P{PZ}l(3)0721708223&P{EP}Rac2EP3118 and P{lacW}Nmtj1C7
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    66A11-66A12
    (determined by in situ hybridisation)
    66A-66A
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Location

    3-23.0

    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (22)
    Genomic Clones (13)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (52)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for database merge of
      Additional comments
      Other Comments

      S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.

      Homologous genetic loci in D.subobscura and D.melanogaster tend to show a similar ultrastructure in the two species.

      Hn is involved in the Trp metabolism and pteridine synthesis.

      Isolation and characterisation of Hn.

      Tryptophan hydrolase catalyses the tetrahydopterin-dependent hydroxylation of L-Phe to yield L-Tyr, the only significant endogenous synthesis of Tyr and the irreversible first step in the phenylalanine degradation pathway. Tryptophan hydrolase activity peaks in pupation and has a minor peak at adult emergence. More likely that H4Bip is the natural cofactor of Hn than H4Ptr.

      Chromatographic pattern of pteridine eye pigments neodrosopterin, sepiapterin, pterin, aurodrosopterin, acetyldihidrohomopterin, isoxanthopterin, biopterin and drosopterin measured in Hn alleles.

      Analysis of variance of developmental time and viability of pteridine pathway mutants in sf, se, Hn, dke and bw, indicated that viability of induced and natural population alleles is the same whereas developmental time tends to be longer for induced mutations as compared to natural population alleles.

      Isolated from a Drosophila adult head cDNA library using a rabbit tryptophan hydroxylase cDNA as a probe under reduced stringency conditions.

      A Hn cDNA has been cloned and sequenced.

      A monoclonal antibody against monkey liver phenylalanine hydroxylase (PH8) (recognising an epitope of residues 139 to 154 of the monkey protein) cross-reacts with a Drosophila protein whose distribution parallels the pattern of phenylalanine hydroxylase activity distribution, with maxima at pupariation and pharate adult formation. Hn mutants show reduced phenylalanine hydroxylase enzyme activity and decreased amounts of protein as assayed in Western blots.

      Isolated from a second larval instar cDNA library using a human pah cDNA as a probe.

      A Hn cDNA has been cloned and sequenced, and its expression pattern has been analysed.

      A mutant of Hn has been shown to influence the level of in vivo detectable 5,6,7,8-tetrahydroperin and 5,6,7,8-tetrahydrobioperin.

      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 78 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      FlyMine - An integrated database for Drosophila genomics
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Synonyms and Secondary IDs (21)
      Reported As
      Secondary FlyBase IDs
      • FBgn0003737
      • FBgn0004089
      • FBgn0005770
      • FBgn0024922
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      References (132)