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Gene Dmel\Hrb98DE

General Information
Symbol	Dmel\Hrb98DE	Species	D. melanogaster
Name	Heterogeneous nuclear ribonucleoprotein at 98DE	Annotation symbol	CG9983
Feature type	protein_coding_gene	FlyBase ID	FBgn0001215
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	hrp38
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	98D6-98D6	Sequence location	3R:24,425,556..24,431,499 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Heterogeneous nuclear ribonucleoprotein at 98DE is referred to in FlyBase by the symbol Dmel\Hrb98DE (CG9983, FBgn0001215). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: sequence-specific DNA binding; mRNA 5'-UTR binding. There is experimental evidence that it is involved in the biological process: negative regulation of RNA splicing; positive regulation of translation; oogenesis; female germ-line stem cell maintenance; regulation of alternative mRNA splicing, via spliceosome; compound eye morphogenesis. 22 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; oocyte; mesothoracic tergum; female germline stem cell. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: Nucleotide-binding, alpha-beta plait; RNA recognition motif domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval midgut, larval Malpighian tubules, adult fat body, adult carcass. Gene sequence location is 3R:24425556..24431499.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Hrb1: hnRNA-binding protein 1 (S. Haynes) Homology to the mammalian A and B hnRNP proteins based on amino acid sequence inferred from nucleotide sequence.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 98D6-98D6   Limits computationally determined from genome sequence between P{PZ}l(3)0648706487 and P{EP}EP3390EP3390
Experimentally Determined Cytological Location
Cytogenetic map Notes References 98D-98E   (determined by in situ hybridisation)   (Matunis et al., 1992) 98D-98E   (determined by in situ hybridisation)   (Haynes et al., 1991) 98D-98E   (determined by in situ hybridisation)   (Haynes et al., 1990) 98D-98E   (determined by in situ hybridisation)   (Haynes et al., 1987)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Hrb98DE for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.46
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Hrb98DE-RA FBtr0085298  NM_170370   2265   364 Hrb98DE-RB FBtr0085300  NM_079819   1542   365 Hrb98DE-RC FBtr0085301  NM_170372   2261   365 Hrb98DE-RD FBtr0085302  NM_170373   1913   361 Hrb98DE-RE FBtr0085299  NM_170371   2253   360 Hrb98DE-RF FBtr0085303  NM_170374   1530   361
Additional Transcript Data & Comments
Reported size (kB)	2.3, 1.6 (northern blot) (Haynes et al., 1990)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Hrb98DE-PA   FBpp0084667   39.0   364   9.05     NP_733249   AAF56800 Hrb98DE-PB   FBpp0084669   39.0   365   9.48     NP_524543   AAF56801 Hrb98DE-PC   FBpp0084670   39.0   365   9.48     NP_733251   AAN14142 Hrb98DE-PD   FBpp0084671   38.6   361   9.62     NP_733252   AAN14143 Hrb98DE-PE   FBpp0084668   38.6   360   9.30     NP_733250   AAN14141 Hrb98DE-PF   FBpp0084672   38.6   361   9.62     NP_733253   AAN14144
Additional Polypeptide Data & Comments
Reported size (kDa)	365 (aa) (Haynes et al., 1987) 365, 364, 361, 360 (aa) (Haynes et al., 1990) 38 (kD observed) (Matunis et al., 1992, Matunis et al., 1992)
Comments	One of several protein products generated by alternative splicing. (FlyBase, 1992-, FlyBase, 1992-, FlyBase, 1992-, FlyBase, 1992-)
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • RNA recognition motif domain (IPR000504) Nucleotide-binding, alpha-beta plait (IPR012677)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201805   AA202129   AA202540   AA246208   AA247078   AA263556   AA263930   AA264091   AA264202   AA264694   AA264977   AA390782   AA391081   AA391352   AA391716   AA392376   AA392386   AA438365   AA439293   AA439619   AA440522   AA441073   AA441686   AA536428   AA536485   AA538791   AA539521   AA540176   AA540260   AA540361   AA540761   AA540901   AA541213   AA694750   AA695124   AA698048   AA735119   AA735321   AA735410   AA735665   AA816777   AA816794   AA820083   AA820277   AA820687   AA941490   AA941508   AA941608   AA941781   AA941784   AA942455   AA942607   AA949079   AA951000   AA951940   AA951953   AA952095   AA979621   AE014297 AAF56800   AE014297 AAF56801   AE014297 AAN14141   AE014297 AAN14142   AE014297 AAN14143   AE014297 AAN14144   AI061749   AI063814   AI109848   AI134702   AI256996   AI293892   AI295253   AI295440   AI386548   AI387509   AI388962   AI389362   AI389774   AI402521   AI402763   AI404550   AI405597   AI454974   AI455008   AI455080   AI455795   AI456242   AI456288   AI456548   AI511713   AI512203   AI512266   AI512572   AI512825   AI513467   AI513619   AI514407   AI514509   AI514727   AI514796   AI515234   AI516477   AI516478   AI517648   AI518753   AI518754   AI519093   AI519281   AI519467   AI530970   AI532708   AI543890   AI544238   AI546147   AI945431   AI945763   AW943425   AX093913   AY061448 AAL28996   BE975251   BE975756   BE975757   BE976685   BE976785   BE977416   BF487070   BF488548   BF489446   BF491647   BF491779   BF493784   BF494123   BF495228   BF497863   BF500297   BF502539   BF503802   BG634262   BG634676   BG634698   BG634933   BG635061   BG635405   BG636067   BG637713   BG638173   BG640986   BG641467   BI162496   BI162864   BI164835   BI165656   BI171362   BI172099   BI173459   BI173770   BI212446   BI213101   BI213242   BI213941   BI213996   BI214295   BI214574   BI214653   BI215081   BI215091   BI216053   BI216841   BI227509   BI227961   BI228144   BI228380   BI228943   BI229263   BI229671   BI231201   BI234105   BI235498   BI235608   BI235824   BI235896   BI236258   BI236784   BI237072   BI237764   BI237804   BI240111   BI240142   BI240772   BI242878   BI243189   BI243202   BI353318   BI354965   BI355618   BI357453   BI361657   BI364018   BI364582   BI366150   BI366164   BI368064   BI369788   BI369901   BI369968   BI370191   BI370721   BI371230   BI371838   BI374527   BI374688   BI374965   BI375192   BI482975   BI484266   BI566897   BI567324   BI567915   BI568434   BI574850   BI576295   BI580736   BI585690   BI585816   BI587513   BI589619   BI605745   BI615307   BI618637   BI619643   BI624385   BI625139   BI628541   BI629816   BI633070   BI633789   BI639941   BP541534   BP543529   BP543530   BP548887   BP553000   BP553001   BP554700   BP554777   BP554778   BP554781   BP554782   BP558359   BP558360   BT099813   BT125883   BT125888   BZ665559   CK132155   CK657882   CK661595   CK662101   CO192141   CO193318   CO195203   CO264653   CO265734   CO268075   CO268476   CO270087   CO272139   CO275230   CO278273   CO294041   CO295844   CO297413   CO298386   CO301890   CO306062   CO307792   CO309609   CO310695   CO311331   CO312946   CO314992   CO320098   CO321955   CO333279   CO337505   CO341381   CO343393   DN154158   EC059732   EC061108   EC063279   EC076010   EC076518   EC076613   EC076812   EC077160   EC079147   EC079853   EC083917   EC084313   EC087002   EC087407   EC201413   EC202993   EC203654   EC212730   EC216697   EC223225   EC225898   EC227214   EC227542   EC236392   EC240931   EC241018   EC244028   EC246309   EC248021   EC254651   EC258776   EC259372   EC259559   EC265204   EL875972   EL875973   EL884769   EL884770   EV575810   EV577805   EV583074   EV591203   EV591527   EV592566   EV594700   GH941561   GH942089   GH942995   GH943639   GH944806   GH944980   GH945603   GH946420   GH946447   GH946516   GH947391   GH949784   GH949871   GH949875   GH950116   GH951613   GH951883   GH951918   GH953199   GH955671   GH955866   GH956877   GH957839   GH957940   GH958476   GH958940   GH959040   GH959401   GH959482   GH959958   GH961381   GH962483   GH962932   GH962998   GH963439   GH964494   GH964630   GH964788   GH966632   GH967231   GH968308   GH968782   GH969040   GH969495   GH969616   GH971243   GH971258   GH972490   GH972880   GH973910   GH974061   GH974346   GH976499   GH976523   GH977012   GH977340   GH977656   GH979085   GH979089   GH979410   GH979431   GH981545   GH983635   M15766 AAA70426   M25545 AAA28621   M25545 AAA28622   M25545 AAA28623   M25545 AAA28624   M28870   M28871   M28872   M31560   M33955   M34319   M60339
UniProtKB/Swiss-Prot	P07909
UniProtKB/TrEMBL	A4V3J6 A4V3J5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   dorsal head epidermis primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 11 -- 12   central brain primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early     (Haynes et al., 1990) embryonic stage     (Haynes et al., 1990) Comment:0-20 hr AEL pupal stage     (Haynes et al., 1990) oogenesis & adult stage | female   ovary   (Haynes et al., 1990) pcr Stage Tissue/Position (including subcellular localization) Reference embryonic stage 16 -- 17     (Haynes et al., 1990) Comment:12-20 hr AEL pupal stage | late     (Haynes et al., 1990) oogenesis & adult stage | female   ovary   (Haynes et al., 1990)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nucleus inferred from direct assay (Ji and Tulin, 2012) polytene chromosome puff inferred from direct assay (Ji and Tulin, 2009) ribonucleoprotein complex inferred from direct assay (Matunis et al., 1992) inferred from physical interaction with sqd (Matunis et al., 1992)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval midgut, larval Malpighian tubules, adult fat body, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    245 central nervous system, larvae L3    283 central nervous system, pupae P8    182 head, virgin 1-day female    51 head, virgin 4-day female    72 head, virgin 20-day female    50 head, mated 1-day female    51 head, mated 4-day female    75 head, mated 20-day female    50 head, mated 1-day male    73 head, mated 4-day male    96 head, mated 20-day male    105 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    28 digestive system, larvae L3 wandering    36 digestive system, 1-day adult    40 digestive system, 4-day adult    69 digestive system, 20-day adult    49 fat body, larvae L3 wandering    24 fat body, white prepupae    83 fat body, pupae P8    96 carcass, larvae L3 wandering    140 carcass, 1-day adult    33 carcass, 4-day adult    57 carcass, 20-day adult    41 ovary, virgin 4-day female    176 ovary, mated 4-day female    214 testis, mated 4-day male    162 accessory gland, mated 4-day male    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (245) central nervous system, larvae L3  (283) central nervous system, pupae P8  (182) head, virgin 1-day female  (51) head, virgin 4-day female  (72) head, virgin 20-day female  (50) head, mated 1-day female  (51) head, mated 4-day female  (75) head, mated 20-day female  (50) head, mated 1-day male  (73) head, mated 4-day male  (96) head, mated 20-day male  (105) salivary gland, larvae L3 wandering    13 salivary gland, white prepupae  (28) digestive system, larvae L3 wandering  (36) digestive system, 1-day adult  (40) digestive system, 4-day adult  (69) digestive system, 20-day adult  (49) fat body, larvae L3 wandering    24 fat body, white prepupae  (83) fat body, pupae P8  (96) carcass, larvae L3 wandering  (140) carcass, 1-day adult  (33) carcass, 4-day adult  (57) carcass, 20-day adult  (41) ovary, virgin 4-day female  (176) ovary, mated 4-day female  (214) testis, mated 4-day male  (162) accessory gland, mated 4-day male  (45) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (245) central nervous system, larvae L3  (283) central nervous system, pupae P8  (182) head, virgin 1-day female    51 head, virgin 4-day female    72 head, virgin 20-day female    50 head, mated 1-day female    51 head, mated 4-day female    75 head, mated 20-day female    50 head, mated 1-day male    73 head, mated 4-day male    96 head, mated 20-day male  105 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    28 digestive system, larvae L3 wandering    36 digestive system, 1-day adult    40 digestive system, 4-day adult    69 digestive system, 20-day adult    49 fat body, larvae L3 wandering    24 fat body, white prepupae    83 fat body, pupae P8    96 carcass, larvae L3 wandering  (140) carcass, 1-day adult    33 carcass, 4-day adult    57 carcass, 20-day adult    41 ovary, virgin 4-day female  (176) ovary, mated 4-day female  (214) testis, mated 4-day male  (162) accessory gland, mated 4-day male    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    245 central nervous system, larvae L3    283 central nervous system, pupae P8    182 head, virgin 1-day female    51 head, virgin 4-day female    72 head, virgin 20-day female    50 head, mated 1-day female    51 head, mated 4-day female    75 head, mated 20-day female    50 head, mated 1-day male    73 head, mated 4-day male    96 head, mated 20-day male    105 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    28 digestive system, larvae L3 wandering    36 digestive system, 1-day adult    40 digestive system, 4-day adult    69 digestive system, 20-day adult    49 fat body, larvae L3 wandering    24 fat body, white prepupae    83 fat body, pupae P8    96 carcass, larvae L3 wandering    140 carcass, 1-day adult    33 carcass, 4-day adult    57 carcass, 20-day adult    41 ovary, virgin 4-day female    176 ovary, mated 4-day female    214 testis, mated 4-day male    162 accessory gland, mated 4-day male    45 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    245 central nervous system, larvae L3    283 central nervous system, pupae P8    182 head, virgin 1-day female    51 head, virgin 4-day female    72 head, virgin 20-day female    50 head, mated 1-day female    51 head, mated 4-day female    75 head, mated 20-day female    50 head, mated 1-day male    73 head, mated 4-day male    96 head, mated 20-day male    105 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    28 digestive system, larvae L3 wandering    36 digestive system, 1-day adult    40 digestive system, 4-day adult    69 digestive system, 20-day adult    49 fat body, larvae L3 wandering    24 fat body, white prepupae    83 fat body, pupae P8    96 carcass, larvae L3 wandering    140 carcass, 1-day adult    33 carcass, 4-day adult    57 carcass, 20-day adult    41 ovary, virgin 4-day female    176 ovary, mated 4-day female    214 testis, mated 4-day male    162 accessory gland, mated 4-day male    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (245) central nervous system, larvae L3  (283) central nervous system, pupae P8  (182) head, virgin 1-day female  (51) head, virgin 4-day female  (72) head, virgin 20-day female  (50) head, mated 1-day female  (51) head, mated 4-day female  (75) head, mated 20-day female  (50) head, mated 1-day male  (73) head, mated 4-day male  (96) head, mated 20-day male  (105) salivary gland, larvae L3 wandering    13 salivary gland, white prepupae  28 digestive system, larvae L3 wandering  (36) digestive system, 1-day adult  (40) digestive system, 4-day adult  (69) digestive system, 20-day adult  (49) fat body, larvae L3 wandering    24 fat body, white prepupae  (83) fat body, pupae P8  (96) carcass, larvae L3 wandering  (140) carcass, 1-day adult  (33) carcass, 4-day adult  (57) carcass, 20-day adult  (41) ovary, virgin 4-day female  (176) ovary, mated 4-day female  (214) testis, mated 4-day male  (162) accessory gland, mated 4-day male  (45) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (245) central nervous system, larvae L3  (283) central nervous system, pupae P8  (182) head, virgin 1-day female    51 head, virgin 4-day female    72 head, virgin 20-day female    50 head, mated 1-day female    51 head, mated 4-day female    75 head, mated 20-day female    50 head, mated 1-day male    73 head, mated 4-day male    96 head, mated 20-day male  105 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    28 digestive system, larvae L3 wandering    36 digestive system, 1-day adult    40 digestive system, 4-day adult    69 digestive system, 20-day adult    49 fat body, larvae L3 wandering    24 fat body, white prepupae    83 fat body, pupae P8    96 carcass, larvae L3 wandering  140 carcass, 1-day adult    33 carcass, 4-day adult    57 carcass, 20-day adult    41 ovary, virgin 4-day female  (176) ovary, mated 4-day female  (214) testis, mated 4-day male  (162) accessory gland, mated 4-day male    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    245 central nervous system, larvae L3    283 central nervous system, pupae P8    182 head, virgin 1-day female    51 head, virgin 4-day female    72 head, virgin 20-day female    50 head, mated 1-day female    51 head, mated 4-day female    75 head, mated 20-day female    50 head, mated 1-day male    73 head, mated 4-day male    96 head, mated 20-day male    105 salivary gland, larvae L3 wandering    13 salivary gland, white prepupae    28 digestive system, larvae L3 wandering    36 digestive system, 1-day adult    40 digestive system, 4-day adult    69 digestive system, 20-day adult    49 fat body, larvae L3 wandering    24 fat body, white prepupae    83 fat body, pupae P8    96 carcass, larvae L3 wandering    140 carcass, 1-day adult    33 carcass, 4-day adult    57 carcass, 20-day adult    41 ovary, virgin 4-day female    176 ovary, mated 4-day female    214 testis, mated 4-day male    162 accessory gland, mated 4-day male    45 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    211 embryo 02-04hr    406 embryo 04-06hr    543 embryo 06-08hr    424 embryo 08-10hr    393 embryo 10-12hr    208 embryo 12-14hr    232 embryo 14-16hr    181 embryo 16-18hr    125 embryo 18-20hr    77 embryo 20-22hr    131 embryo 22-24hr    116 larva L1    88 larva L2    72 larva L3 12hr old    65 larva L3 puffstage 1-2    50 larva L3 puffstage 3-6    102 larva L3 puffstage 7-9    122 white prepupae new    115 white prepupae 12hr    145 white prepupae 24hr    173 pupae 2d postWPP    140 pupae 3d postWPP    83 pupae 4d postWPP    74 adult male 01day    89 adult male 05day    128 adult male 30day    130 adult female 01day    87 adult female 05day    138 adult female 30day    129 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (211) embryo 02-04hr  (406) embryo 04-06hr  (543) embryo 06-08hr  (424) embryo 08-10hr  (393) embryo 10-12hr  (208) embryo 12-14hr  (232) embryo 14-16hr  (181) embryo 16-18hr  (125) embryo 18-20hr  (77) embryo 20-22hr  (131) embryo 22-24hr  (116) larva L1  (88) larva L2  (72) larva L3 12hr old  (65) larva L3 puffstage 1-2  (50) larva L3 puffstage 3-6  (102) larva L3 puffstage 7-9  (122) white prepupae new  (115) white prepupae 12hr  (145) white prepupae 24hr  (173) pupae 2d postWPP  (140) pupae 3d postWPP  (83) pupae 4d postWPP  (74) adult male 01day  (89) adult male 05day  (128) adult male 30day  (130) adult female 01day  (87) adult female 05day  (138) adult female 30day  (129) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (211) embryo 02-04hr  (406) embryo 04-06hr  (543) embryo 06-08hr  (424) embryo 08-10hr  (393) embryo 10-12hr  (208) embryo 12-14hr  (232) embryo 14-16hr  (181) embryo 16-18hr  (125) embryo 18-20hr    77 embryo 20-22hr  (131) embryo 22-24hr  (116) larva L1    88 larva L2    72 larva L3 12hr old    65 larva L3 puffstage 1-2    50 larva L3 puffstage 3-6  102 larva L3 puffstage 7-9  (122) white prepupae new  (115) white prepupae 12hr  (145) white prepupae 24hr  (173) pupae 2d postWPP  (140) pupae 3d postWPP    83 pupae 4d postWPP    74 adult male 01day    89 adult male 05day  (128) adult male 30day  (130) adult female 01day    87 adult female 05day  (138) adult female 30day  (129) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    211 embryo 02-04hr    406 embryo 04-06hr    543 embryo 06-08hr    424 embryo 08-10hr    393 embryo 10-12hr    208 embryo 12-14hr    232 embryo 14-16hr    181 embryo 16-18hr    125 embryo 18-20hr    77 embryo 20-22hr    131 embryo 22-24hr    116 larva L1    88 larva L2    72 larva L3 12hr old    65 larva L3 puffstage 1-2    50 larva L3 puffstage 3-6    102 larva L3 puffstage 7-9    122 white prepupae new    115 white prepupae 12hr    145 white prepupae 24hr    173 pupae 2d postWPP    140 pupae 3d postWPP    83 pupae 4d postWPP    74 adult male 01day    89 adult male 05day    128 adult male 30day    130 adult female 01day    87 adult female 05day    138 adult female 30day    129 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    211 embryo 02-04hr    406 embryo 04-06hr    543 embryo 06-08hr    424 embryo 08-10hr    393 embryo 10-12hr    208 embryo 12-14hr    232 embryo 14-16hr    181 embryo 16-18hr    125 embryo 18-20hr    77 embryo 20-22hr    131 embryo 22-24hr    116 larva L1    88 larva L2    72 larva L3 12hr old    65 larva L3 puffstage 1-2    50 larva L3 puffstage 3-6    102 larva L3 puffstage 7-9    122 white prepupae new    115 white prepupae 12hr    145 white prepupae 24hr    173 pupae 2d postWPP    140 pupae 3d postWPP    83 pupae 4d postWPP    74 adult male 01day    89 adult male 05day    128 adult male 30day    130 adult female 01day    87 adult female 05day    138 adult female 30day    129 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (211) embryo 02-04hr  (406) embryo 04-06hr  (543) embryo 06-08hr  (424) embryo 08-10hr  (393) embryo 10-12hr  (208) embryo 12-14hr  (232) embryo 14-16hr  (181) embryo 16-18hr  (125) embryo 18-20hr  (77) embryo 20-22hr  (131) embryo 22-24hr  (116) larva L1  (88) larva L2  (72) larva L3 12hr old  (65) larva L3 puffstage 1-2  (50) larva L3 puffstage 3-6  (102) larva L3 puffstage 7-9  (122) white prepupae new  (115) white prepupae 12hr  (145) white prepupae 24hr  (173) pupae 2d postWPP  (140) pupae 3d postWPP  (83) pupae 4d postWPP  (74) adult male 01day  (89) adult male 05day  (128) adult male 30day  (130) adult female 01day  (87) adult female 05day  (138) adult female 30day  (129) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (211) embryo 02-04hr  (406) embryo 04-06hr  (543) embryo 06-08hr  (424) embryo 08-10hr  (393) embryo 10-12hr  (208) embryo 12-14hr  (232) embryo 14-16hr  (181) embryo 16-18hr  125 embryo 18-20hr    77 embryo 20-22hr  131 embryo 22-24hr  116 larva L1    88 larva L2    72 larva L3 12hr old    65 larva L3 puffstage 1-2    50 larva L3 puffstage 3-6  102 larva L3 puffstage 7-9  122 white prepupae new  115 white prepupae 12hr  (145) white prepupae 24hr  (173) pupae 2d postWPP  140 pupae 3d postWPP    83 pupae 4d postWPP    74 adult male 01day    89 adult male 05day  128 adult male 30day  130 adult female 01day    87 adult female 05day  138 adult female 30day  129 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    211 embryo 02-04hr    406 embryo 04-06hr    543 embryo 06-08hr    424 embryo 08-10hr    393 embryo 10-12hr    208 embryo 12-14hr    232 embryo 14-16hr    181 embryo 16-18hr    125 embryo 18-20hr    77 embryo 20-22hr    131 embryo 22-24hr    116 larva L1    88 larva L2    72 larva L3 12hr old    65 larva L3 puffstage 1-2    50 larva L3 puffstage 3-6    102 larva L3 puffstage 7-9    122 white prepupae new    115 white prepupae 12hr    145 white prepupae 24hr    173 pupae 2d postWPP    140 pupae 3d postWPP    83 pupae 4d postWPP    74 adult male 01day    89 adult male 05day    128 adult male 30day    130 adult female 01day    87 adult female 05day    138 adult female 30day    129 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    236 Schneider line 2 Sg4    108 embryonic 1182-4H    187 embryonic GM2    83 embryonic Kc167    158 embryonic S1    225 embryonic S3    163 leg disc CME L1    127 wing disc CME-W2    102 wing disc ML-DmD8    188 wing disc ML-DmD9    202 wing disc ML-DmD16-c3    192 wing disc ML-DmD21    131 wing disc ML-DmD32    142 haltere disc ML-DmD17-c3    191 eye-antennal disc ML-DmD11    182 antennal disc ML-DmD20-c5    102 mixed discs ML-DmD4-c1    127 CNS ML-DmBG1-c1    227 CNS ML-DmBG2-c2    89 tumorous blood cells mbn2    159 ovary fGS/OSS    302 ovary OSC    200 ovary OSS    173 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (236) Schneider line 2 Sg4  (108) embryonic 1182-4H  (187) embryonic GM2  (83) embryonic Kc167  (158) embryonic S1  (225) embryonic S3  (163) leg disc CME L1  (127) wing disc CME-W2  (102) wing disc ML-DmD8  (188) wing disc ML-DmD9  (202) wing disc ML-DmD16-c3  (192) wing disc ML-DmD21  (131) wing disc ML-DmD32  (142) haltere disc ML-DmD17-c3  (191) eye-antennal disc ML-DmD11  (182) antennal disc ML-DmD20-c5  (102) mixed discs ML-DmD4-c1  (127) CNS ML-DmBG1-c1  (227) CNS ML-DmBG2-c2  (89) tumorous blood cells mbn2  (159) ovary fGS/OSS  (302) ovary OSC  (200) ovary OSS  (173) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (236) Schneider line 2 Sg4  (108) embryonic 1182-4H  (187) embryonic GM2    83 embryonic Kc167  (158) embryonic S1  (225) embryonic S3  (163) leg disc CME L1  (127) wing disc CME-W2  102 wing disc ML-DmD8  (188) wing disc ML-DmD9  (202) wing disc ML-DmD16-c3  (192) wing disc ML-DmD21  (131) wing disc ML-DmD32  (142) haltere disc ML-DmD17-c3  (191) eye-antennal disc ML-DmD11  (182) antennal disc ML-DmD20-c5  102 mixed discs ML-DmD4-c1  (127) CNS ML-DmBG1-c1  (227) CNS ML-DmBG2-c2    89 tumorous blood cells mbn2  (159) ovary fGS/OSS  (302) ovary OSC  (200) ovary OSS  (173) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    236 Schneider line 2 Sg4    108 embryonic 1182-4H    187 embryonic GM2    83 embryonic Kc167    158 embryonic S1    225 embryonic S3    163 leg disc CME L1    127 wing disc CME-W2    102 wing disc ML-DmD8    188 wing disc ML-DmD9    202 wing disc ML-DmD16-c3    192 wing disc ML-DmD21    131 wing disc ML-DmD32    142 haltere disc ML-DmD17-c3    191 eye-antennal disc ML-DmD11    182 antennal disc ML-DmD20-c5    102 mixed discs ML-DmD4-c1    127 CNS ML-DmBG1-c1    227 CNS ML-DmBG2-c2    89 tumorous blood cells mbn2    159 ovary fGS/OSS    302 ovary OSC    200 ovary OSS    173 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    236 Schneider line 2 Sg4    108 embryonic 1182-4H    187 embryonic GM2    83 embryonic Kc167    158 embryonic S1    225 embryonic S3    163 leg disc CME L1    127 wing disc CME-W2    102 wing disc ML-DmD8    188 wing disc ML-DmD9    202 wing disc ML-DmD16-c3    192 wing disc ML-DmD21    131 wing disc ML-DmD32    142 haltere disc ML-DmD17-c3    191 eye-antennal disc ML-DmD11    182 antennal disc ML-DmD20-c5    102 mixed discs ML-DmD4-c1    127 CNS ML-DmBG1-c1    227 CNS ML-DmBG2-c2    89 tumorous blood cells mbn2    159 ovary fGS/OSS    302 ovary OSC    200 ovary OSS    173 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (236) Schneider line 2 Sg4  (108) embryonic 1182-4H  (187) embryonic GM2  (83) embryonic Kc167  (158) embryonic S1  (225) embryonic S3  (163) leg disc CME L1  (127) wing disc CME-W2  (102) wing disc ML-DmD8  (188) wing disc ML-DmD9  (202) wing disc ML-DmD16-c3  (192) wing disc ML-DmD21  (131) wing disc ML-DmD32  (142) haltere disc ML-DmD17-c3  (191) eye-antennal disc ML-DmD11  (182) antennal disc ML-DmD20-c5  (102) mixed discs ML-DmD4-c1  (127) CNS ML-DmBG1-c1  (227) CNS ML-DmBG2-c2  (89) tumorous blood cells mbn2  (159) ovary fGS/OSS  (302) ovary OSC  (200) ovary OSS  (173) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (236) Schneider line 2 Sg4  108 embryonic 1182-4H  (187) embryonic GM2    83 embryonic Kc167  (158) embryonic S1  (225) embryonic S3  (163) leg disc CME L1  127 wing disc CME-W2  102 wing disc ML-DmD8  (188) wing disc ML-DmD9  (202) wing disc ML-DmD16-c3  (192) wing disc ML-DmD21  131 wing disc ML-DmD32  142 haltere disc ML-DmD17-c3  (191) eye-antennal disc ML-DmD11  (182) antennal disc ML-DmD20-c5  102 mixed discs ML-DmD4-c1  127 CNS ML-DmBG1-c1  (227) CNS ML-DmBG2-c2    89 tumorous blood cells mbn2  (159) ovary fGS/OSS  (302) ovary OSC  (200) ovary OSS  (173) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    236 Schneider line 2 Sg4    108 embryonic 1182-4H    187 embryonic GM2    83 embryonic Kc167    158 embryonic S1    225 embryonic S3    163 leg disc CME L1    127 wing disc CME-W2    102 wing disc ML-DmD8    188 wing disc ML-DmD9    202 wing disc ML-DmD16-c3    192 wing disc ML-DmD21    131 wing disc ML-DmD32    142 haltere disc ML-DmD17-c3    191 eye-antennal disc ML-DmD11    182 antennal disc ML-DmD20-c5    102 mixed discs ML-DmD4-c1    127 CNS ML-DmBG1-c1    227 CNS ML-DmBG2-c2    89 tumorous blood cells mbn2    159 ovary fGS/OSS    302 ovary OSC    200 ovary OSS    173 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    110 cold shock, 4-day adult    88 heat shock, 4-day adult    109 Cadmium 50 mM 6 hrs, larvae L3    42 Cadmium 50 mM 12 hrs, larvae L3    53 Cadmium 50 mM 48 hrs, 4-day adult    95 Cadmium 100 mM 48 hrs, 4-day adult    172 Copper 0.5 mM 12 hrs, larvae L3    82 Copper 15 mM 48 hrs, 4-day adult    173 Zinc 5 mM 12 hrs, larvae L3    60 Zinc 4.5 mM 48 hrs, 4-day adult    129 Ethanol 2.5% 3 hrs, larvae L3    164 Ethanol 5% 3 hrs, larvae L3    28 Ethanol 10% 3 hrs, larvae L3    55 Caffeine 1.5 mg/ml 4 hrs, larvae L3    25 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    148 Caffeine 25 mg/ml 48 hrs, 4-day adult    127 Paraquat 5 mM 48 hrs, 4-day adult    145 Paraquat 10 mM 48 hrs, 4-day adult    151 Rotenone 2 μg 12 hrs, larvae L3    48 Rotenone 8 μg 12 hrs, larvae L3    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (110) cold shock, 4-day adult  (88) heat shock, 4-day adult  (109) Cadmium 50 mM 6 hrs, larvae L3  (42) Cadmium 50 mM 12 hrs, larvae L3  (53) Cadmium 50 mM 48 hrs, 4-day adult  (95) Cadmium 100 mM 48 hrs, 4-day adult  (172) Copper 0.5 mM 12 hrs, larvae L3  (82) Copper 15 mM 48 hrs, 4-day adult  (173) Zinc 5 mM 12 hrs, larvae L3  (60) Zinc 4.5 mM 48 hrs, 4-day adult  (129) Ethanol 2.5% 3 hrs, larvae L3  (164) Ethanol 5% 3 hrs, larvae L3  (28) Ethanol 10% 3 hrs, larvae L3  (55) Caffeine 1.5 mg/ml 4 hrs, larvae L3    25 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (148) Caffeine 25 mg/ml 48 hrs, 4-day adult  (127) Paraquat 5 mM 48 hrs, 4-day adult  (145) Paraquat 10 mM 48 hrs, 4-day adult  (151) Rotenone 2 μg 12 hrs, larvae L3  (48) Rotenone 8 μg 12 hrs, larvae L3  (38) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (110) cold shock, 4-day adult    88 heat shock, 4-day adult  (109) Cadmium 50 mM 6 hrs, larvae L3    42 Cadmium 50 mM 12 hrs, larvae L3    53 Cadmium 50 mM 48 hrs, 4-day adult    95 Cadmium 100 mM 48 hrs, 4-day adult  (172) Copper 0.5 mM 12 hrs, larvae L3    82 Copper 15 mM 48 hrs, 4-day adult  (173) Zinc 5 mM 12 hrs, larvae L3    60 Zinc 4.5 mM 48 hrs, 4-day adult  (129) Ethanol 2.5% 3 hrs, larvae L3  (164) Ethanol 5% 3 hrs, larvae L3    28 Ethanol 10% 3 hrs, larvae L3    55 Caffeine 1.5 mg/ml 4 hrs, larvae L3    25 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (148) Caffeine 25 mg/ml 48 hrs, 4-day adult  (127) Paraquat 5 mM 48 hrs, 4-day adult  (145) Paraquat 10 mM 48 hrs, 4-day adult  (151) Rotenone 2 μg 12 hrs, larvae L3    48 Rotenone 8 μg 12 hrs, larvae L3    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    110 cold shock, 4-day adult    88 heat shock, 4-day adult    109 Cadmium 50 mM 6 hrs, larvae L3    42 Cadmium 50 mM 12 hrs, larvae L3    53 Cadmium 50 mM 48 hrs, 4-day adult    95 Cadmium 100 mM 48 hrs, 4-day adult    172 Copper 0.5 mM 12 hrs, larvae L3    82 Copper 15 mM 48 hrs, 4-day adult    173 Zinc 5 mM 12 hrs, larvae L3    60 Zinc 4.5 mM 48 hrs, 4-day adult    129 Ethanol 2.5% 3 hrs, larvae L3    164 Ethanol 5% 3 hrs, larvae L3    28 Ethanol 10% 3 hrs, larvae L3    55 Caffeine 1.5 mg/ml 4 hrs, larvae L3    25 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    148 Caffeine 25 mg/ml 48 hrs, 4-day adult    127 Paraquat 5 mM 48 hrs, 4-day adult    145 Paraquat 10 mM 48 hrs, 4-day adult    151 Rotenone 2 μg 12 hrs, larvae L3    48 Rotenone 8 μg 12 hrs, larvae L3    38 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    110 cold shock, 4-day adult    88 heat shock, 4-day adult    109 Cadmium 50 mM 6 hrs, larvae L3    42 Cadmium 50 mM 12 hrs, larvae L3    53 Cadmium 50 mM 48 hrs, 4-day adult    95 Cadmium 100 mM 48 hrs, 4-day adult    172 Copper 0.5 mM 12 hrs, larvae L3    82 Copper 15 mM 48 hrs, 4-day adult    173 Zinc 5 mM 12 hrs, larvae L3    60 Zinc 4.5 mM 48 hrs, 4-day adult    129 Ethanol 2.5% 3 hrs, larvae L3    164 Ethanol 5% 3 hrs, larvae L3    28 Ethanol 10% 3 hrs, larvae L3    55 Caffeine 1.5 mg/ml 4 hrs, larvae L3    25 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    148 Caffeine 25 mg/ml 48 hrs, 4-day adult    127 Paraquat 5 mM 48 hrs, 4-day adult    145 Paraquat 10 mM 48 hrs, 4-day adult    151 Rotenone 2 μg 12 hrs, larvae L3    48 Rotenone 8 μg 12 hrs, larvae L3    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (110) cold shock, 4-day adult  (88) heat shock, 4-day adult  (109) Cadmium 50 mM 6 hrs, larvae L3  (42) Cadmium 50 mM 12 hrs, larvae L3  (53) Cadmium 50 mM 48 hrs, 4-day adult  (95) Cadmium 100 mM 48 hrs, 4-day adult  (172) Copper 0.5 mM 12 hrs, larvae L3  (82) Copper 15 mM 48 hrs, 4-day adult  (173) Zinc 5 mM 12 hrs, larvae L3  (60) Zinc 4.5 mM 48 hrs, 4-day adult  (129) Ethanol 2.5% 3 hrs, larvae L3  (164) Ethanol 5% 3 hrs, larvae L3  28 Ethanol 10% 3 hrs, larvae L3  (55) Caffeine 1.5 mg/ml 4 hrs, larvae L3    25 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (148) Caffeine 25 mg/ml 48 hrs, 4-day adult  (127) Paraquat 5 mM 48 hrs, 4-day adult  (145) Paraquat 10 mM 48 hrs, 4-day adult  (151) Rotenone 2 μg 12 hrs, larvae L3  (48) Rotenone 8 μg 12 hrs, larvae L3  (38) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  110 cold shock, 4-day adult    88 heat shock, 4-day adult  109 Cadmium 50 mM 6 hrs, larvae L3    42 Cadmium 50 mM 12 hrs, larvae L3    53 Cadmium 50 mM 48 hrs, 4-day adult    95 Cadmium 100 mM 48 hrs, 4-day adult  (172) Copper 0.5 mM 12 hrs, larvae L3    82 Copper 15 mM 48 hrs, 4-day adult  (173) Zinc 5 mM 12 hrs, larvae L3    60 Zinc 4.5 mM 48 hrs, 4-day adult  129 Ethanol 2.5% 3 hrs, larvae L3  (164) Ethanol 5% 3 hrs, larvae L3    28 Ethanol 10% 3 hrs, larvae L3    55 Caffeine 1.5 mg/ml 4 hrs, larvae L3    25 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (148) Caffeine 25 mg/ml 48 hrs, 4-day adult  127 Paraquat 5 mM 48 hrs, 4-day adult  (145) Paraquat 10 mM 48 hrs, 4-day adult  (151) Rotenone 2 μg 12 hrs, larvae L3    48 Rotenone 8 μg 12 hrs, larvae L3    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    110 cold shock, 4-day adult    88 heat shock, 4-day adult    109 Cadmium 50 mM 6 hrs, larvae L3    42 Cadmium 50 mM 12 hrs, larvae L3    53 Cadmium 50 mM 48 hrs, 4-day adult    95 Cadmium 100 mM 48 hrs, 4-day adult    172 Copper 0.5 mM 12 hrs, larvae L3    82 Copper 15 mM 48 hrs, 4-day adult    173 Zinc 5 mM 12 hrs, larvae L3    60 Zinc 4.5 mM 48 hrs, 4-day adult    129 Ethanol 2.5% 3 hrs, larvae L3    164 Ethanol 5% 3 hrs, larvae L3    28 Ethanol 10% 3 hrs, larvae L3    55 Caffeine 1.5 mg/ml 4 hrs, larvae L3    25 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    148 Caffeine 25 mg/ml 48 hrs, 4-day adult    127 Paraquat 5 mM 48 hrs, 4-day adult    145 Paraquat 10 mM 48 hrs, 4-day adult    151 Rotenone 2 μg 12 hrs, larvae L3    48 Rotenone 8 μg 12 hrs, larvae L3    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_30 mE1_20_mRNA_expression_cluster_10
External Data & Images
Linkouts	BDGP expression data • LD38464 RE34829 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001215 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9983-RB;CG9983-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Hrb98DECA06921 Hrb98DEd05172 lethal, with Scer\GAL4Act5C.PI Hrb98DEGD14939 lethal, with Scer\GAL4αTub84B.PL Hrb98DEGD14939 partially lethal - majority die | larval stage (with Df(3R)Exel6209) Hrb98DEd05172 viable Hrb98DECC01563 Hrb98DEZCL0588 viable, with Scer\GAL4pnr-MD237 Hrb98DEGD14939 Sterility Allele female semi-sterile (with Df(3R)Exel6209) Hrb98DEd05172 fertile Hrb98DEZCL0588 Other Phenotypes Allele body color defective, with Scer\GAL4pnr-MD237 Hrb98DEGD14939 planar polarity defective, with Scer\GAL4pnr-MD237 Hrb98DEGD14939 visible, with Scer\GAL4pnr-MD237 Hrb98DEGD14939 Phenotype manifest in Allele chaeta | supernumerary, with Scer\GAL4pnr-MD237 Hrb98DEGD14939 egg chamber | anterior (with Df(3R)Exel6209) Hrb98DEd05172 egg chamber | lateral (with Df(3R)Exel6209) Hrb98DEd05172 female germline stem cell (with Df(3R)Exel6209) Hrb98DEd05172 mesothoracic tergum, with Scer\GAL4pnr-MD237 Hrb98DEGD14939 oocyte (with Df(3R)Exel6209) Hrb98DEd05172 trichogen cell, with Scer\GAL4pnr-MD237 Hrb98DEGD14939
Classical Alleles ( 13 )
For All Classical Alleles Show
Allele of Hrb98DE Class Mutagen Stocks Known lesion Hrb98DEA544 1 -- Hrb98DEd05172 hypomorphic allele - molecular evidence 1 -- Hrb98DENP3125 1 -- Hrb98DEZCL0588 P-element activity 1 -- Hrb98DECA06921 P-element activity 0 Yes Hrb98DECC01563 P-element activity 0 Yes Hrb98DECPTI000165 piggyBac transposase 0 Yes Hrb98DECPTI000205 piggyBac transposase 0 Yes Hrb98DECPTI003669 piggyBac transposase 0 Yes Hrb98DEDG25708 P-element activity 0 -- Hrb98DEEY01550 P-element activity 0 -- Hrb98DES038907 P-element activity 0 -- Hrb98DEWee-P25 0 Yes
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Hrb98DE Class Mutagen Stocks Known lesion Hrb98DEGD14939 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Hrb98DEHMS00342 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Hrb98DEJF01249 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Hrb98DE1A.hs in vitro construct - regulatory fusion 0 Yes Hrb98DE1B.hs in vitro construct - regulatory fusion 0 Yes Hrb98DENIG.9983R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Hrb98DEScer\UAS.cSa in vitro construct - regulatory fusion 0 Yes Hrb98DEScer\UAS.P\T.T:Disc\RFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Hrb98DEScer\UAS.T:Disc\RFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6209 (Ji and Tulin, 2009, Ji and Tulin, 2012)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD14939} NA P{NIG.9983R} NA P{TRiP.HMS00342} NA P{TRiP.JF01249} NA P{UAS-Hrb98DE.RFP} NA P{UAS-Hrb98DE.S} NA P{UASp-Hrb98DE.RFP} NA heat-shock construct P{L3} NA P{ov12} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system P{GawB}Hrb98DENP3125 No insertion of mobile activating element P{EPgy2}Hrb98DEEY01550 NA P{XP}Hrb98DEd05172 NA miscellaneous insertions P{PTT-GA}Hrb98DECA06921 NA P{PTT-GC}Hrb98DECC01563 NA P{PTT-GC}Hrb98DEZCL0588 NA P{Wee-P.ph0}Hrb98DEWee-P25 NA P{wHy}Hrb98DEDG25708 NA PBac{5HPw+}Hrb98DEA544 NA PBac{602.P.SVS-1}Hrb98DECPTI000165 NA PBac{602.P.SVS-1}Hrb98DECPTI000205 NA PBac{768.FSVS-0}Hrb98DECPTI003669 NA insertion of enhancer trap P{lacW}Hrb98DES038907 No
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 11 terms )
Molecular Function
CV term Evidence References
mRNA 5'-UTR binding inferred from direct assay (Ji and Tulin, 2012) sequence-specific DNA binding inferred from direct assay (Borah et al., 2009)
Biological Process
CV term Evidence References
compound eye morphogenesis inferred from genetic interaction with human CELF1 (Sofola et al., 2007) female germ-line stem cell maintenance inferred from mutant phenotype (Ji and Tulin, 2012) negative regulation of RNA splicing inferred from mutant phenotype (Ji and Tulin, 2009) oogenesis inferred from mutant phenotype (Ji and Tulin, 2012) positive regulation of translation inferred from mutant phenotype (Ji and Tulin, 2012) regulation of alternative mRNA splicing, via spliceosome inferred from mutant phenotype (Borah et al., 2009)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Ji and Tulin, 2012) polytene chromosome puff inferred from direct assay (Ji and Tulin, 2009) ribonucleoprotein complex inferred from direct assay (Matunis et al., 1992) inferred from physical interaction with sqd (Matunis et al., 1992)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
mRNA binding inferred from sequence or structural similarity (Lasko, 2000) non-traceable author statement (Swiss-Prot Project Members, 1988.8.1) nucleotide binding inferred from electronic annotation with InterPro:IPR012677 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
ribonucleoprotein complex inferred from sequence or structural similarity with human HNRPA1 (Matunis et al., 1992) non-traceable author statement (Swiss-Prot Project Members, 1988.8.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Hrb98DE - Hrb87F experimental knowledge based (Guruharsha et al., 2011) Hrb98DE - PGRP-LB experimental knowledge based (Guruharsha et al., 2011) Hrb98DE - glo experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Hrb98DE allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68261 DroID - A comprehensive database of gene and protein interactions. • FBgn0001215 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43385
Orthologs
OrthoDB Orthologs (155) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6H46Q5 Dipteran inclusive ortholog search EOG6W3SX3 Insect inclusive ortholog search EOG65TBJ9 Arthropod inclusive ortholog search EOG6X69RF Metazoa inclusive ortholog search EOG6G20CW
Orthologs in Drosophila Species (EOG6H46Q5)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Hrb98DE     Drosophila sechellia   Dsec\GM16385 Y   Drosophila erecta   Dere\GG11603 Y   Drosophila yakuba   Dyak\GE23791 Y   Drosophila ananassae   Dana\GF18582 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA26796 Y   Drosophila persimilis   Dper\GL13791 Y   Drosophila willistoni   Dwil\GK12096 Y   Drosophila virilis   Dvir\GJ22934 Y   Drosophila mojavensis   Dmoj\GI10577 Y   Drosophila grimshawi   Dgri\GH17116 Y
Orthologs in non-Drosophila Dipterans (EOG6W3SX3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL010467 Y Anopheles gambiae Malaria mosquito  Agam\AGAP002374 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ001612 Y
Orthologs in non-Dipteran Insects (EOG65TBJ9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB41392 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008807 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19277 Y Atta cephalotes Leafcutter ant  Acep\ACEP15101 Y Linepithema humile Argentine ant  Lhum\LH16171 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB17027 Y Solenopsis invicta Red fire ant  Sinv\SINV24695 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI009542 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI001865 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI002624 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI003661 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI002060 Y Bombyx mori Silkmoth  Bmor\BGIBMGA007822 Y Bombyx mori Silkmoth  Bmor\BGIBMGA006405 Y Pediculus humanus Human body louse  Phum\PHUM050860 Y Pediculus humanus Human body louse  Phum\PHUM451750 Y Tribolium castaneum Red flour beetle  Tcas\TC004556 Y
Orthologs in non-Insect Arthropods (EOG6X69RF)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_307331 Y Ixodes scapularis Deer tick  Isca\ISCW011438 Y
Orthologs in non-Arthropod Metazoa (EOG6G20CW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\sqd-1 Y Caenorhabditis elegans Nematode  Cele\hrp-1 Y Caenorhabditis elegans Nematode  Cele\H28G03.1 Y Caenorhabditis elegans Nematode  Cele\msi-1 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_022512gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008172gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015676gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020274gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026906gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002003gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007318gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_017609gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024306gn Y Danio rerio Zebrafish  Drer\hnrnpd Y Danio rerio Zebrafish  Drer\hnrnpa1 Y Danio rerio Zebrafish  Drer\zgc:66127 Y Danio rerio Zebrafish  Drer\dazap1 Y Danio rerio Zebrafish  Drer\msi2a Y Danio rerio Zebrafish  Drer\hnrnpab Y Danio rerio Zebrafish  Drer\msi2b Y Danio rerio Zebrafish  Drer\hnrnpa0l Y Danio rerio Zebrafish  Drer\hnrpdl Y Danio rerio Zebrafish  Drer\zgc:77366 Y Danio rerio Zebrafish  Drer\msi1 Y Danio rerio Zebrafish  Drer\zgc:77052 Y Danio rerio Zebrafish  Drer\hnrnpa3 Y Danio rerio Zebrafish  Drer\hnrnpa0 Y Xenopus tropicalis Western clawed frog  Xtro\dazap1 Y Xenopus tropicalis Western clawed frog  Xtro\msi1 Y Xenopus tropicalis Western clawed frog  Xtro\hnrnpd Y Xenopus tropicalis Western clawed frog  Xtro\hnrnpa2b1 Y Xenopus tropicalis Western clawed frog  Xtro\hnrpdl Y Xenopus tropicalis Western clawed frog  Xtro\hnrnpa0 Y Xenopus tropicalis Western clawed frog  Xtro\hnrnpa1 Y Xenopus tropicalis Western clawed frog  Xtro\hnrnpa3 Y Xenopus tropicalis Western clawed frog  Xtro\hnrnpab Y Gallus gallus Domestic chicken  Ggal\DAZAP1 Y Gallus gallus Domestic chicken  Ggal\HNRNPA0 Y Gallus gallus Domestic chicken  Ggal\HNRNPA2B1 Y Gallus gallus Domestic chicken  Ggal\HNRNPAB Y Gallus gallus Domestic chicken  Ggal\HNRNPA3 Y Gallus gallus Domestic chicken  Ggal\HNRPDL Y Gallus gallus Domestic chicken  Ggal\MSI2 Y Gallus gallus Domestic chicken  Ggal\HNRNPD Y Gallus gallus Domestic chicken  Ggal\MSI2 Y Mus musculus House mouse  Mmus\Gm6793 Y Mus musculus House mouse  Mmus\Dazap1 Y Mus musculus House mouse  Mmus\Hnrnpa3 Y Mus musculus House mouse  Mmus\Hnrpdl Y Mus musculus House mouse  Mmus\Hnrnpa1 Y Mus musculus House mouse  Mmus\Gm7551 Y Mus musculus House mouse  Mmus\Gm8991 Y Mus musculus House mouse  Mmus\Msi1 Y Mus musculus House mouse  Mmus\ENSMUSG00000004980 Y Mus musculus House mouse  Mmus\Hnrnpab Y Mus musculus House mouse  Mmus\Rbm31y Y Mus musculus House mouse  Mmus\Hnrnpa0 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000031608 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000021254 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000013650 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000030250 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000032168 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000023438 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000031972 Y Rattus norvegicus Norway rat  Rnor\Msi1 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000031316 Y Rattus norvegicus Norway rat  Rnor\Hnrpdl Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000021280 Y Rattus norvegicus Norway rat  Rnor\RGD1564416 Y Rattus norvegicus Norway rat  Rnor\Msi2 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000025891 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000024652 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000042093 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000021929 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000032584 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000017651 Y Rattus norvegicus Norway rat  Rnor\Dazap1 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000029641 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000039436 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000005951 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000007252 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000027915 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000021986 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000024895 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000042377 Y Rattus norvegicus Norway rat  Rnor\Hnrnpa2b1 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000011100 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000005671 Y Rattus norvegicus Norway rat  Rnor\Hnrnpa1 Y Rattus norvegicus Norway rat  Rnor\Hnrpd Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000017364 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000029434 Y Rattus norvegicus Norway rat  Rnor\Hnrnpab Y Rattus norvegicus Norway rat  Rnor\LOC100360986 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000039876 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000029531 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000033211 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000042924 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000043173 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000039983 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000038905 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000033182 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000027605 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000022655 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000025482 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000029898 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000030901 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000032616 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000027006 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000038392 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000022285 Y Homo sapiens Human  Hsap\HNRNPA0 Y Homo sapiens Human  Hsap\DAZAP1 Y Homo sapiens Human  Hsap\HNRNPA2B1 Y Homo sapiens Human  Hsap\ENSG00000197451 Y Homo sapiens Human  Hsap\HNRNPD Y Homo sapiens Human  Hsap\MSI2 Y Homo sapiens Human  Hsap\HNRNPA1L2 Y Homo sapiens Human  Hsap\ENSG00000135486 Y Homo sapiens Human  Hsap\HNRNPA3 Y Homo sapiens Human  Hsap\HNRPDL Y Homo sapiens Human  Hsap\MSI1 Y
Human Orthologs (11)
Gene OMIM HGNC Hsap\HNRNPA0     Hsap\DAZAP1     Hsap\HNRNPA2B1     Hsap\ENSG00000197451     Hsap\HNRNPD     Hsap\MSI2     Hsap\HNRNPA1L2     Hsap\ENSG00000135486     Hsap\HNRNPA3     Hsap\HNRPDL     Hsap\MSI1
AAA Orthologs (10) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila sechellia Dsec\GM16385 Drosophila erecta Dere\GG11603 Drosophila yakuba Dyak\GE23791 Drosophila ananassae Dana\GF18582 Drosophila pseudoobscura pseudoobscura Dpse\GA26796 Drosophila persimilis Dper\GL13791 Drosophila willistoni Dwil\GK12096 Drosophila virilis Dvir\GJ22934 Drosophila mojavensis Dmoj\GI10577 Drosophila grimshawi Dgri\GH17116
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	31303 y1 v1; P{TRiP.JF01249}attP2 32351 y1 sc* v1; P{TRiP.HMS00342}attP2 6822 y1 w1118; P{PTT-GC}Hrb98DEZCL0588 16137 y1 w1118; PBac{5HPw+}Hrb98DEA544/TM3, Sb1 Ser1
Harvard	- P{XP}Hrb98DEd05172
Kyoto	113115 w*; P{GawB}Hrb98DENP3125
VDRC	v29523 w1118; P{GD14939}v29523 v29524 w1118; P{GD14939}v29524/CyO
Genomic Clones ( 1 )
	BACR09F18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 376 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT02853 LD38464 LD46071
Other clones	RE34829
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT02135 AT02547 AT04104 AT05010 AT12166 AT15143 AT18204 AT21745 AT24011 AT25566 AT28443 AT28687 AT30419 AT30971 AT31005 AT31340 AT31522 AT31986 GH03903 GH09229 GH18056 GH20026 GH21032 GH28689 GM01472 GM02175 GM23115 GM29074 GM31621 LD01528 LD02251 LD03733 LD05150 LD05993 LD07191 LD08618 LD08811 LD09958 LD10215 LD10333 LD10370 LD11228 LD11239 LD14233 LD15853 LD16693 LD19572 LD19827 LD20565 LD20774 LD21056 LD21108 LD21262 LD21704 LD22221 LD24536 LD25674 LD26685 LD29150 LD34849 LD35489 LD36180 LD39073 LD40901 LD41038 LD42358 LD42359 LD44044 LD44480 LD44886 LD45558 LD45819 LD46239 LD46488 LD46971 LD47709 LP04261 LP08834 LP13455 LP21196 RE01792 RE02122 RE05589 RE14063 RE17539 RE19671 RE20061 RE20432 RE20521 RE21290 RE22858 RE24123 RE25353 RE25918 RE26610 RE29116 RE29746 RE31348 RE31496 RE31847 RE32903 RE33228 RE34053 RE36792 RE37688 RE40352 RE40753 RE43946 RE49738 RE51617 RE53974 RE56084 RE56238 RE56323 RE56621 RE57449 RE58842 RE62345 RE65787 RE67341 RE74962 SD01782 SD04301 SD12184 SD12818 SD13656 SD22667 SD27041 SD27949
Other clones	14489 17406 31168 33038 58748 60684 65345 75975 76017 78153 83093 83873 97983 99541 105492 106844 117520 118718 119056 122882 149622 172719 177251 214447.2 273418 281133 297887 bs12g09 bs16f02 bs40e09 bs44f02 bs54f06 bs55g11 bs63g05 CK01.5C.E4 CK01.33B.D7 CK01.37D.F6 CK01.127A.B6 Dmel_dig_009821_0650_1568 Dmel_dig_013435_0635_1226 Dmel_dig_018998_0580_2353 Dmel_neb_011998_0585_1304 Dmel_neb_012392_0404_2461 Dmel_neb_013177_0577_1746 Dmel_neb_014055_0315_2316 EC33238 EC35586 EC39859 EC254651 EC258776 EC259372 EK090106 EK091618 EK097339 EK106008 EK116827 EK129616 EK139819 EK143514 EK172901 EK182519 EK186857 EK192518 EK205548 EK211736 EK216922 EK218561 EK222313 EK224149 EK230728 EK238660 EK250206 EK255658 EK282219 EK306364 EN14660 EP12345 EP16713 FGC002F11 FGC021A01 FGM002D06 FGM222A06 FGM231C06 FGM231F09 FGM231F11 FGM314E06 GH12236 GH16663 GH20512 GH21758 GH22051 GH24303 GH25657 HL03679 IP05864 IP16016 LD01095 LD01110 LD02228 LD03753 LD07066 LD07784 LD07818 LD08501 LD11662 LD12626 LD13413 LD13821 LD17038 LD17115 LD17689 LD18395 LD19684 LD19980 LD23811 LD25654 LD25833 LD25966 LD25971 LD26925 LD27835 LD31214 LD32857 LD32872 LD34318 LD36128 LD36605 LD38386 LD38463 LD38809 LD41226 LD43205 LD43965 LD45750 LP07146 LP09067 LP22071 RE04585 RE13117 RE16390 RE16870 RE18427 RE18607 RE19592 RE20629 RE21307 RE24579 RE25589 RE27013 RE27502 RE31762 RE32291 RE34121 RE36760 RE40767 RE45974 RE49042 RE51640 RE58079 RE62144 RE62662 RE62945 RH03079 RH25322 RH25490 RH27092 RH28207 RH32830 RH36686 RH37455 RH39227 RH39880 RH44912 RH49512 RH50718 RH56975 RH58735 RH63936 RH65121 RH71646 RP004016129 RP004018686 RP004032542 RP004046964 RP004049060 RP004070379 RP004089976 RP004092561 RP004133387 RP004151829 RP004152617 RP004156601 RP004177020 RP004179210 RP004179598 RP004179764 RP004207789 RP004209958 RP004219226 RP004219823 RP004220074 RP004228607 RP004230247 RP004234300 RP004237658 RP004248798 RP004250413 RP004251232 RP004252193 RP004254778 RP004255178 RP004259967 RP004266236 RP004284047 RP004294914 RP004304698 RP004317515 RP004317917 RP004366070 RP004370640 RP004373772 RP004389999 RP004395843 RP004415036 RP004415438 RP004438901 RP004441525 RP004447242 RP004450198 RP004456866 RP004470039 RP004477154 RP004499114 RP004501815 RP004503463 RP004514539 RP004519173 RP004520037 RP004524665 RP004535990 RP004550311 RP004557927 RP004560042
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0001215 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43385
Antibody Information
	monoclonal (Matunis et al., 1992) polyclonal (Blanchette et al., 2009, Borah et al., 2009)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	Area matching Drosophila hnRNP gene Acc. No. M28870. (Davies, 2001.3.15) The relationship between the mutationally defined genes in the 98D region (l(3)98Da, l(3)98Dh, l(3)98Di, l(3)98Dj, l(3)98Dc, l(3)98Dd, l(3)98Dk and l(3)98Dm) and molecularly defined genes (anon-98Da, anon-98Db, anon-98Dc, anon-98Dd, dfk and Hrb98DE) has not yet been determined. (Cass, 1997.7.17) The consequences of HRB overexpression and absence in living flies is examined. (Zu et al., 1996) Complete deletion of Hrb87F has no obvious defect on viability or fertility, but when in combined with hypodosage of Hrb98DE leads to reduced male and female fertility. (Haynes et al., 1995) Overexpression of Hrb98DE leads to skipping of all internal exons in the Ddc pre-mRNA in vivo, regardless of the normal Ddc splice site choice. These results indicate Hrb98DE has a splicing activity that promotes the use of terminal splice sites. (Shen et al., 1995) An Hrb98DE cDNA clone has been isolated and sequenced. (Matunis et al., 1992) Hrb98DE has been cloned and sequenced. Eight transcripts, which can generate four protein isoforms, are produced by the use of alternative exons and splice acceptor sites. (Haynes et al., 1990) Transcription unit defined during molecular analysis of the fkh gene region. (Weigel et al., 1989) Isolated from a pupal cDNA library, using a fragment of the fs(1)h coding region containing "pen" repetitive sequences (GGN, where N is any nucleotide) as the probe. (Haynes et al., 1987) A Hrb98DE cDNA has been cloned and sequenced. The predicted amino acid sequence has strong homology to a rat single-stranded nucleic acid binding protein. (Haynes et al., 1987) This gene was also isolated by Knust et al. (1987) as a clone that cross-hybridized to a Delta probe.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079819 NM_170370 NM_170371 NM_170372 NM_170373 NM_170374 RefSeq (Proteins) • NP_524543 NP_733249 NP_733250 NP_733251 NP_733252 NP_733253 DDBJ / EMBL / GenBank • AAA28621 AAA28622 AAA28623 AAA28624 AAA70426 AAF56800 AAF56801 AAL28996 AAN14141 AAN14142 AAN14143 AAN14144 AI293892 AI404550 AI518754 AI945431 AI945763 AW943425 AX093913 AY061448 BZ665559 M15766 M25545 M28870 M28871 M28872 M31560 M33955 M34319 M60339 Entrez Gene - A searchable database of RefSeq genes. • 43385 UniProtKB/Swiss-Prot • P07909 UniProtKB/TrEMBL • A4V3J5 A4V3J6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • RNA recognition motif domain (IPR000504) Nucleotide-binding, alpha-beta plait (IPR012677) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD38464 RE34829
Linkouts
	BioGRID - A database of protein and genetic interactions • 68261 DroID - A comprehensive database of gene and protein interactions. • FBgn0001215 DRSC - Results from RNAi screens. • FBgn0001215 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001215 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9983-RB;CG9983-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0001215 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43385 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 43385 modMine - Data generated by the modENCODE project. • FBgn0001215
Synonyms & Secondary IDs ( 17 )
Reported As
Symbol Synonym	anon-E7Δ6   CG9983 (Whitfield, 2000.5.9, Whitfield, 2000.4.28, Huang et al., 2005, Quinones-Coello, 2007, Andersen and Tapon, 2008, Pisa et al., 2009, Ji and Tulin, 2009, Ni et al., 2008, Ni et al., 2010.12.1, Ellis and Carney, 2011) E7Δ6 (Weigel et al., 1989) HDP(P9) (Voelker et al., 1991) hnRNP A2/B1 (Tan et al., 2012) Hrb1   hrb98DE (Clyne et al., 2003) Hrb98DE (Sofola et al., 2007, Buszczak et al., 2007, Quinones-Coello, 2007, Pisa et al., 2009, Zhou et al., 2008, Pinnola et al., 2007, Curtis et al., 2007, Ellis and Carney, 2011, Tan et al., 2012, Japanese National Institute of Genetics, 2012.5.21) Hrb98 de (Sofola et al., 2007) hrb98 de (Sofola et al., 2007) HRB98DE (Sofola et al., 2007) HRB98DE/hrp38 (Beyer et al., 1996) hrp38 (Matunis et al., 1992, Matunis et al., 1992, Sofola et al., 2007, Blanchette et al., 2009, Borah et al., 2009, Ji and Tulin, 2009, Olson et al., 2007, Ji and Tulin, 2012) p9 (Haynes et al., 1987) Pen9
Name Synonym	Heterogeneous nuclear ribonucleoprotein at 98DE (Pisa et al., 2009) hnRNA-binding protein 1
Secondary FlyBase IDs
	FBgn0003056 FBgn0014945
References ( 69 )
Generate a list of	All references relating to this gene ( 69 )
List References by type	Research paper  ( 31 ) Supplementary material  ( 6 ) Review  ( 1 ) Personal communication to FlyBase  ( 19 ) Abstract  ( 3 ) FlyBase analysis  ( 2 ) Stock list  ( 1 ) Patent  ( 1 ) DNA/RNA sequence record  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 3 )
	Ji and Tulin, 2012, Nat. Commun. 3: 760 Poly(ADP-ribose) controls DE-cadherin-dependent stem cell maintenance and oocyte localization. [FBrf0217856] Tan et al., 2012, Hum. Mol. Genet. 21(1): 57--65 Retrotransposon activation contributes to fragile X premutation rCGG-mediated neurodegeneration. [FBrf0216915] Ellis and Carney, 2011, Genetics 187(1): 157--169 Socially-Responsive Gene Expression in Male Drosophila melanogaster Is Influenced by the Sex of the Interacting Partner. [FBrf0212780] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...