FB2020_03, released Jun 16, 2020

Gene: Dmel\Hrb98DE

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General Information
Symbol
Dmel\Hrb98DE
Species
D. melanogaster
Name
Heterogeneous nuclear ribonucleoprotein at 98DE
Annotation Symbol
CG9983
Feature Type
protein_coding_gene
FlyBase ID
FBgn0001215
Gene Model Status
Current
Stock Availability
18 publicly available
Gene Snapshot
Heterogeneous nuclear ribonucleoprotein at 98DE (Hrb98DE) encodes a nuclear RNA-binding protein. It controls hnRNA stability, splicing, IRES-dependent translation, and translational repression. It represents one of the main targets of the poly(ADP-ribosyl)ation pathway. It also regulates tissue polarity patterning and germ-line stem cell fate. [Date last reviewed: 2019-03-07]
Other Summaries
Also Known As

hrp38

Key Links
Genomic Location
Cytogenetic map
98D6-98D6
Sequence location
3R:28,599,834..28,605,777 [+]
Recombination map

3-96

RefSeq locus
NT_033777 REGION:28599834..28605777
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (19 terms)
Molecular Function (7 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
mRNA 5'-UTR binding
inferred from direct assay
(Ji and Tulin, 2012)
sequence-specific DNA binding
inferred from direct assay
(Borah et al., 2009)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
mRNA 3'-UTR binding
inferred from biological aspect of ancestor with PANTHER:PTN002689981
(assigned by GO_Central )
(Gaudet et al., 2011)
mRNA binding
inferred from sequence or structural similarity
(Lasko, 2000)
poly(G) binding
inferred from biological aspect of ancestor with PANTHER:PTN002689981
(assigned by GO_Central )
(Gaudet et al., 2011)
poly(U) RNA binding
inferred from biological aspect of ancestor with PANTHER:PTN002689981
(assigned by GO_Central )
(Gaudet et al., 2011)
RNA binding
inferred from biological aspect of ancestor with PANTHER:PTN002689974
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (9 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
compound eye morphogenesis
inferred from genetic interaction with HGNC:2549
(Sofola et al., 2007)
female germ-line stem cell population maintenance
inferred from mutant phenotype
(Ji and Tulin, 2012)
negative regulation of RNA splicing
inferred from mutant phenotype
(Ji and Tulin, 2009)
oogenesis
inferred from mutant phenotype
(Ji and Tulin, 2012)
positive regulation of translation
inferred from mutant phenotype
(Ji and Tulin, 2012)
regulation of alternative mRNA splicing, via spliceosome
inferred from mutant phenotype
(Borah et al., 2009)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
positive regulation of mRNA splicing, via spliceosome
inferred from biological aspect of ancestor with PANTHER:PTN002689981
(assigned by GO_Central )
(Gaudet et al., 2011)
regulation of RNA metabolic process
inferred from biological aspect of ancestor with PANTHER:PTN002689974
(assigned by GO_Central )
(Gaudet et al., 2011)
spermatogenesis
inferred from biological aspect of ancestor with PANTHER:PTN001924359
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
nucleus
inferred from direct assay
(Ji and Tulin, 2012)
inferred from high throughput direct assay
(Lye et al., 2014)
polytene chromosome puff
inferred from direct assay
(Ji and Tulin, 2009)
ribonucleoprotein complex
inferred from direct assay
(Matunis et al., 1992)
inferred from physical interaction with FLYBASE:sqd; FB:FBgn0263396
(Matunis et al., 1992)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
nucleus
inferred from biological aspect of ancestor with PANTHER:PTN002309896
(assigned by GO_Central )
(Gaudet et al., 2011)
ribonucleoprotein complex
inferred from biological aspect of ancestor with PANTHER:PTN002689974
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity with HGNC:5031
(Matunis et al., 1992)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
SPLICEOSOME COMPLEX A -
Nuclear pre-mRNA splicing is catalyzed by the spliceosome which assembles in a step-wise manner. Complex A, the pre-spliceosome, is composed of U1 and U2 snRNPs and proteins involved in recognition of the 5' splice site and branch point. (Adapted from PMID:24452469 and PMID:23118483).
Protein Function (UniProtKB)
This protein is a component of ribonucleosomes.
(UniProt, P07909)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
Hrb1: hnRNA-binding protein 1 (S. Haynes)
Homology to the mammalian A and B hnRNP proteins based on amino acid sequence inferred from nucleotide sequence.
Gene Model and Products
Number of Transcripts
6
Number of Unique Polypeptides
4

Please see the GBrowse view of Dmel\Hrb98DE or the JBrowse view of Dmel\Hrb98DE for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Hrb98DE-RA
FBtr0085298
NM_170370
2265
364
Hrb98DE-RB
FBtr0085300
NM_079819
1542
365
Hrb98DE-RC
FBtr0085301
NM_170372
2261
365
Hrb98DE-RD
FBtr0085302
NM_170373
1913
361
Hrb98DE-RE
FBtr0085299
NM_170371
2253
360
Hrb98DE-RF
FBtr0085303
NM_170374
1530
361
Additional Transcript Data and Comments
Reported size (kB)

2.3, 1.6 (northern blot)

(Haynes et al., 1990)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Hrb98DE-PA
FBpp0084667
39.0
364
9.05
NP_733249
AAF56800
Hrb98DE-PB
FBpp0084669
39.0
365
9.48
NP_524543
AAF56801
Hrb98DE-PC
FBpp0084670
39.0
365
9.48
NP_733251
AAN14142
Hrb98DE-PD
FBpp0084671
38.6
361
9.62
NP_733252
AAN14143
Hrb98DE-PE
FBpp0084668
38.6
360
9.30
NP_733250
AAN14141
Hrb98DE-PF
FBpp0084672
38.6
361
9.62
NP_733253
AAN14144
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

361 aa isoforms: Hrb98DE-PD, Hrb98DE-PF
365 aa isoforms: Hrb98DE-PB, Hrb98DE-PC
Additional Polypeptide Data and Comments
Reported size (kDa)

38 (kD observed)

(Matunis et al., 1992, Matunis et al., 1992)

365, 364, 361, 360 (aa)

(Haynes et al., 1990)

365 (aa)

(Haynes et al., 1987)
Comments

One of several protein products generated by alternative splicing.

(FlyBase, 1992-)
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hrb98DE using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | female
ovary
(Pisa et al., 2009)
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
nucleus
inferred from direct assay
(Ji and Tulin, 2012)
inferred from high throughput direct assay
(Lye et al., 2014)
polytene chromosome puff
inferred from direct assay
(Ji and Tulin, 2009)
ribonucleoprotein complex
inferred from direct assay
(Matunis et al., 1992)
inferred from physical interaction with FLYBASE:sqd; FB:FBgn0263396
(Matunis et al., 1992)
Expression Deduced from Reporters
Reporter: Mi{PT-GFSTF.1}Hrb98DEMI10594-GFSTF.1
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
embryonic/larval brain
(Nagarkar-Jaiswal et al., 2015)
Reporter: P{PTT-GC}Hrb98DEZCL0588
Stage
Tissue/Position (including subcellular localization)
Reference
oogenesis & adult stage | female
follicle cell
• nucleus
(Cooley et al., 2002.10-2003.5)
nurse cell
• nucleus
(Cooley et al., 2002.10-2003.5)
Reporter: PBac{602.P.SVS-1}Hrb98DECPTI000165
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain cell body rind
(Knowles-Barley, 2011.8.24)
spermatogenesis
primary spermatocyte
(Lowe et al., 2014)
Y chromosome loop
(Lowe et al., 2014)
oogenesis
nurse cell
(Lowe et al., 2014)
follicle cell
(Lowe et al., 2014)
Reporter: PBac{602.P.SVS-1}Hrb98DECPTI000205
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain cell body rind
(Knowles-Barley, 2011.8.24)
spermatogenesis
primary spermatocyte
(Lowe et al., 2014)
Y chromosome loop
(Lowe et al., 2014)
oogenesis
nurse cell
(Lowe et al., 2014)
follicle cell
(Lowe et al., 2014)
Reporter: PBac{768.FSVS-0}Hrb98DECPTI003669
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain cell body rind

Comment: punctate expression in adult brain cortex

(Knowles-Barley, 2011.8.24)
adult gnathal ganglion
(Knowles-Barley, 2011.8.24)
adult brain

Comment: low expression throughout adult brain

(Knowles-Barley, 2011.8.24)
spermatogenesis
primary spermatocyte
(Lowe et al., 2014)
Y chromosome loop
(Lowe et al., 2014)
oogenesis
nurse cell
(Lowe et al., 2014)
follicle cell
(Lowe et al., 2014)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Hrb98DE in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 20 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 15 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Hrb98DE
Transgenic constructs containing regulatory region of Hrb98DE
Deletions and Duplications ( 1 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4Act5C.PI
lethal, with Scer\GAL4αTub84B.PL
lethal | female limited, with Scer\GAL4dome-PG14
partially lethal - majority die, with Scer\GAL4VGlut-OK371
partially lethal - majority die (with Df(3R)Exel6209)
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
female semi-sterile, with Scer\GAL4VP16.otu
female semi-sterile (with Df(3R)Exel6209)
fertile
Other Phenotypes
Allele
body color defective, with Scer\GAL4pnr-MD237
cell adhesion defective | oogenesis, with Scer\GAL4slbo.2.6
cell migration defective | oogenesis | oogenesis, with Scer\GAL4slbo.2.6
flightless, with Scer\GAL4Mef2.PR
locomotor behavior defective | adult stage, with Scer\GAL4elav.PU
majority die during pharate adult stage, with Scer\GAL4VGlut-OK371
pain response defective | adult stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
planar polarity defective, with Scer\GAL4pnr-MD237
short lived, with Scer\GAL4elav.PU
some die during larval stage (with Df(3R)Exel6209)
visible, with Scer\GAL4Mhc.PW
visible, with Scer\GAL4nub-AC-62
visible, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
border follicle cell, with Scer\GAL4slbo.2.6
chaeta | supernumerary, with Scer\GAL4pnr-MD237
egg chamber | anterior (with Df(3R)Exel6209)
egg chamber | lateral (with Df(3R)Exel6209)
embryonic/larval fat body | third instar larval stage, with Scer\GAL4Cg.PA
female germline stem cell (with Df(3R)Exel6209)
indirect flight muscle, with Scer\GAL4Mhc.PW
indirect flight muscle | progressive, with Scer\GAL4Mhc.PW
mesothoracic tergum, with Scer\GAL4pnr-MD237
mitochondrion | third instar larval stage, with Scer\GAL4Cg.PA
myofibril, with Scer\GAL4Mef2.PR
oocyte (with Df(3R)Exel6209)
sarcomere, with Scer\GAL4Mef2.PR
trichogen cell, with Scer\GAL4pnr-MD237
wing, with Scer\GAL4Mhc.PW
wing, with Scer\GAL4nub-AC-62
Z disc, with Scer\GAL4Mef2.PR
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (30)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\HNRNPA2B1
12 of 15
Yes
Yes
4  
Hsap\HNRNPA1
9 of 15
No
Yes
3  
Hsap\HNRNPA1L2
9 of 15
No
Yes
Hsap\HNRNPA3
9 of 15
No
Yes
Hsap\HNRNPA0
5 of 15
No
Yes
Hsap\DAZAP1
2 of 15
No
No
Hsap\HNRNPAB
2 of 15
No
No
Hsap\BOLL
1 of 15
No
No
1  
Hsap\CIRBP
1 of 15
No
Yes
Hsap\DAZL
1 of 15
No
No
1  
Hsap\EIF4B
1 of 15
No
No
Hsap\EIF4H
1 of 15
No
No
Hsap\HNRNPC
1 of 15
No
No
1  
Hsap\HNRNPCL2
1 of 15
No
No
Hsap\HNRNPCL3
1 of 15
No
No
Hsap\HNRNPCL4
1 of 15
No
No
Hsap\HNRNPD
1 of 15
No
No
Hsap\HNRNPDL
1 of 15
No
No
3  
Hsap\MIR4444-1
1 of 15
No
Yes
Hsap\RALY
1 of 15
No
No
Hsap\RALYL
1 of 15
No
No
Hsap\RBM3
1 of 15
No
Yes
Hsap\RBM34
1 of 15
No
No
Hsap\SLIRP
1 of 15
No
No
Hsap\SRSF10
1 of 15
No
No
Hsap\SRSF12
1 of 15
No
No
Hsap\TRA2A
1 of 15
No
No
1  
Hsap\TRA2B
1 of 15
No
No
Hsap\TRNAU1AP
1 of 15
No
No
Hsap\ZCRB1
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (34)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Hnrnpa2b1
12 of 15
Yes
Yes
Mmus\Hnrnpa1
11 of 15
No
Yes
Mmus\Hnrnpa3
8 of 15
No
Yes
Mmus\Hnrnpa0
5 of 15
No
Yes
Mmus\Dazap1
2 of 15
No
No
Mmus\Gm6793
2 of 15
No
Yes
Mmus\Hnrnpa1l2-ps2
2 of 15
No
Yes
Mmus\Hnrnpab
2 of 15
No
No
Mmus\Boll
1 of 15
No
No
Mmus\Cirbp
1 of 15
No
Yes
Mmus\Dazl
1 of 15
No
No
Mmus\Eif4b
1 of 15
No
No
Mmus\Eif4h
1 of 15
No
No
Mmus\Gm9242
1 of 15
No
Yes
Mmus\Gm9833
1 of 15
No
No
Mmus\Gm12666
1 of 15
No
No
Mmus\Gm21379
1 of 15
No
No
Mmus\Hnrnpc
1 of 15
No
No
Mmus\Hnrnpdl
1 of 15
No
No
Mmus\Hnrnpd
1 of 15
No
No
Mmus\Larp7
1 of 15
No
No
Mmus\Myef2
1 of 15
No
No
Mmus\Ralyl
1 of 15
No
No
Mmus\Raly
1 of 15
No
No
Mmus\Rbm3
1 of 15
No
Yes
Mmus\Rbm31y
1 of 15
No
No
Mmus\Rbm34
1 of 15
No
No
Mmus\Slirp
1 of 15
No
No
Mmus\Srsf10
1 of 15
No
No
Mmus\Srsf12
1 of 15
No
No
Mmus\Tra2a
1 of 15
No
No
Mmus\Tra2b
1 of 15
No
No
Mmus\Trnau1ap
1 of 15
No
No
Mmus\Zcrb1
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (29)
Rnor\Hnrnpa2b1
10 of 13
Yes
Yes
Rnor\Hnrnpa1
9 of 13
No
Yes
Rnor\Hnrnpa3
8 of 13
No
Yes
Rnor\LOC681410
4 of 13
No
Yes
Rnor\Dazap1
2 of 13
No
No
Rnor\LOC679581
2 of 13
No
Yes
Rnor\LOC103689931
2 of 13
No
No
Rnor\Boll
1 of 13
No
No
Rnor\Cirbp
1 of 13
No
Yes
Rnor\Dazl
1 of 13
No
No
Rnor\Eif4b
1 of 13
No
No
Rnor\Eif4h
1 of 13
No
No
Rnor\Hnrnpab
1 of 13
No
No
Rnor\Hnrnpc
1 of 13
No
No
Rnor\Hnrnpdl
1 of 13
No
No
Rnor\Hnrnpd
1 of 13
No
No
Rnor\Larp7
1 of 13
No
No
Rnor\LOC100911576
1 of 13
No
No
Rnor\Myef2
1 of 13
No
No
Rnor\Ralyl
1 of 13
No
No
Rnor\Raly
1 of 13
No
No
Rnor\Rbm3
1 of 13
No
Yes
Rnor\Rbm31y
1 of 13
No
No
Rnor\Rbm34
1 of 13
No
No
Rnor\Slirp
1 of 13
No
No
Rnor\Srsf10
1 of 13
No
No
Rnor\Tra2a
1 of 13
No
No
Rnor\Tra2b
1 of 13
No
No
Rnor\Zcrb1
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (23)
Xtro\hnrnpa2b1
7 of 12
Yes
Yes
Xtro\hnrnpa1
5 of 12
No
Yes
Xtro\hnrnpa3
5 of 12
No
Yes
Xtro\hnrnpa0
4 of 12
No
Yes
Xtro\hnrnpab
2 of 12
No
No
Xtro\cirbp
1 of 12
No
Yes
Xtro\dazap1
1 of 12
No
No
Xtro\dazl
1 of 12
No
No
Xtro\eif4b
1 of 12
No
No
Xtro\eif4h
1 of 12
No
No
Xtro\hnrnpc
1 of 12
No
No
Xtro\hnrnpdl
1 of 12
No
No
Xtro\hnrnpd
1 of 12
No
No
Xtro\larp7
1 of 12
No
No
Xtro\ralyl
1 of 12
No
No
Xtro\raly
1 of 12
No
No
Xtro\rbm34
1 of 12
No
No
Xtro\srsf10
1 of 12
No
No
Xtro\srsf12
1 of 12
No
No
Xtro\tra2a
1 of 12
No
No
Xtro\tra2b
1 of 12
No
No
Xtro\trnau1ap
1 of 12
No
No
Xtro\zcrb1
1 of 12
No
Yes
Danio rerio (Zebrafish) (32)
Drer\hnrnpa3
8 of 15
Yes
Yes
Drer\hnrnpa1b
7 of 15
No
Yes
Drer\hnrnpa0a
5 of 15
No
Yes
Drer\hnrnpa0b
5 of 15
No
Yes
Drer\hnrnpa1a
5 of 15
No
Yes
Drer\hnrnpa0l
4 of 15
No
Yes
Drer\dazap1
2 of 15
No
No
Drer\hnrnpaba
2 of 15
No
No
Drer\hnrnpabb
2 of 15
No
No
Drer\cirbpa
1 of 15
No
Yes
Drer\cirbpb
1 of 15
No
Yes
Drer\dazl
1 of 15
No
No
Drer\eif4ba
1 of 15
No
No
Drer\eif4bb
1 of 15
No
No
Drer\eif4h
1 of 15
No
No
Drer\hnrnpc
1 of 15
No
No
Drer\hnrnpd
1 of 15
No
No
Drer\hnrnpdl
1 of 15
No
No
Drer\larp7
1 of 15
No
No
Drer\ncl
1 of 15
No
No
Drer\ncoa5
1 of 15
No
No
Drer\raly
1 of 15
No
No
Drer\ralyl
1 of 15
No
No
Drer\rbm34
1 of 15
No
No
Drer\slirp
1 of 15
No
No
Drer\srsf10a
1 of 15
No
No
Drer\tra2a
1 of 15
No
No
Drer\tra2b
1 of 15
No
No
Drer\trnau1apa
1 of 15
No
No
Drer\trnau1apb
1 of 15
No
No
Drer\zcrb1
1 of 15
No
Yes
Drer\zgc:55733
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (8)
Cele\hrp-1
10 of 15
Yes
Yes
Cele\daz-1
1 of 15
No
No
Cele\H28G03.1
1 of 15
No
No
Cele\rbm-34
1 of 15
No
No
Cele\slrp-1
1 of 15
No
No
Cele\T07F10.3
1 of 15
No
No
Cele\tdp-1
1 of 15
No
No
Cele\ZK616.61
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (40)
Atha\AT5G40490
4 of 9
Yes
Yes
Atha\AT3G13224
3 of 9
No
No
Atha\AT2G22100
2 of 9
No
Yes
Atha\AT2G33410
2 of 9
No
No
Atha\AT4G14300
2 of 9
No
No
Atha\ARP1
1 of 9
No
Yes
Atha\AT1G01080
1 of 9
No
Yes
Atha\AT1G22910
1 of 9
No
Yes
Atha\AT1G60000
1 of 9
No
No
Atha\AT1G78260
1 of 9
No
No
Atha\AT2G14160
1 of 9
No
Yes
Atha\AT2G19380
1 of 9
No
No
Atha\AT2G22088
1 of 9
No
Yes
Atha\AT2G35410
1 of 9
No
No
Atha\AT2G37220
1 of 9
No
Yes
Atha\AT2G41060
1 of 9
No
Yes
Atha\AT2G46780
1 of 9
No
Yes
Atha\AT3G06970
1 of 9
No
Yes
Atha\AT3G15010
1 of 9
No
No
Atha\AT4G09040
1 of 9
No
Yes
Atha\AT4G36960
1 of 9
No
No
Atha\AT5G03495
1 of 9
No
Yes
Atha\AT5G06210
1 of 9
No
Yes
Atha\AT5G19030
1 of 9
No
Yes
Atha\AT5G51730
1 of 9
No
Yes
Atha\AT5G53680
1 of 9
No
No
Atha\AT5G53700
1 of 9
No
Yes
Atha\AT5G53720
1 of 9
No
No
Atha\AT5G59865
1 of 9
No
Yes
Atha\CP29
1 of 9
No
Yes
Atha\CP31B
1 of 9
No
No
Atha\CP33
1 of 9
No
No
Atha\GR-RBP3
1 of 9
No
Yes
Atha\GR-RBP5
1 of 9
No
Yes
Atha\NUC-L1
1 of 9
No
Yes
Atha\NUC-L2
1 of 9
No
Yes
Atha\PHIP1
1 of 9
No
Yes
Atha\RBP31
1 of 9
No
No
Atha\UBA1A
1 of 9
No
Yes
Atha\UBA2A
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (17)
Scer\HRP1
3 of 15
Yes
No
Scer\NGR1
2 of 15
No
No
Scer\CWC2
1 of 15
No
No
Scer\GBP2
1 of 15
No
No
Scer\HRB1
1 of 15
No
No
Scer\LHP1
1 of 15
No
No
Scer\MRN1
1 of 15
No
Yes
Scer\MUD1
1 of 15
No
No
Scer\NAB3
1 of 15
No
No
Scer\NAB6
1 of 15
No
Yes
Scer\NAM8
1 of 15
No
No
Scer\NOP12
1 of 15
No
No
Scer\PUB1
1 of 15
No
No
Scer\SBP1
1 of 15
No
Yes
Scer\TIF3
1 of 15
No
No
Scer\WHI3
1 of 15
No
No
Scer\WHI4
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (4)
Spom\SPBC660.15
2 of 12
Yes
No
Spom\gar2
1 of 12
No
No
Spom\msa1
1 of 12
No
Yes
Spom\tcg1
1 of 12
No
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190E5G )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila simulans
Dsim\GD28673
Drosophila sechellia
Dsec\GM16385
Drosophila erecta
Dere\GG11603
Drosophila yakuba
Dyak\GE23791
Drosophila ananassae
Dana\GF18582
Drosophila pseudoobscura pseudoobscura
Dpse\GA26796
Drosophila persimilis
Dper\GL13791
Drosophila willistoni
Dwil\GK12096
Drosophila virilis
Dvir\GJ22934
Drosophila mojavensis
Dmoj\GI10577
Drosophila grimshawi
Dgri\GH17116
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091509JW )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17012906
Musca domestica
House fly
Mdoa\17012219
Musca domestica
House fly
Mdoa\17007490
Glossina morsitans
Tsetse fly
Gmor\GMOY011801
Glossina morsitans
Tsetse fly
Gmor\GMOY011807
Glossina morsitans
Tsetse fly
Gmor\GMOY004983
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_11849
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_07866
Mayetiola destructor
Hessian fly
Mdes\Mdes000181
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL010467
Anopheles darlingi
American malaria mosquito
Adar\ADAC010434
Anopheles gambiae
Malaria mosquito
Agam\AGAP002374
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ001612
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0C1B )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA007822
Bombyx mori
Silkmoth
Bmor\BGIBMGA006405
Danaus plexippus
Monarch butterfly
Dple\DPOGS210978-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS210987-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL025015
Heliconius melpomene
Postman butterfly
Hmel\HMEL025014
Apis florea
Little honeybee
Aflo\2304947460
Apis mellifera
Western honey bee
Amel\GB41392
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP13295
Bombus terrestris
Buff-tailed bumblebee
Bter\15206642
Linepithema humile
Argentine ant
Lhum\LH16171
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00127b
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008807
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_11231
Tribolium castaneum
Red flour beetle
Tcas\TC004556
Pediculus humanus
Human body louse
Phum\PHUM050860
Rhodnius prolixus
Kissing bug
Rpro\RPRC006072
Rhodnius prolixus
Kissing bug
Rpro\RPRC014833
Cimex lectularius
Bed bug
Clec\CLEC002407
Cimex lectularius
Bed bug
Clec\CLEC001845
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002060
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI009542
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001865
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002624
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI003661
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_05654
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_09984
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_01707
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0BZ0 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR005105
Strigamia maritima
European centipede
Smar\SMAR010196
Strigamia maritima
European centipede
Smar\SMAR010292
Ixodes scapularis
Black-legged tick
Isca\ISCW011438
Stegodyphus mimosarum
African social velvet spider
Smim\KFM70891.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM61723.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g08180
Tetranychus urticae
Two-spotted spider mite
Turt\tetur30g00180
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_307331
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G1CPI )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_022512gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hnrpa
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Dazap
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Msi1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hnrpa2B1L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Unk_9
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Dazap_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_007318gn
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000022958
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000017374
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000003877
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000003362
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000013663
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000018579
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000004062
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000016737
Gallus gallus
Domestic chicken
Ggal\DAZAP1
Gallus gallus
Domestic chicken
Ggal\HNRNPA0
Gallus gallus
Domestic chicken
Ggal\HNRNPA2B1
Gallus gallus
Domestic chicken
Ggal\HNRNPAB
Gallus gallus
Domestic chicken
Ggal\HNRNPA3
Gallus gallus
Domestic chicken
Ggal\HNRPDL
Gallus gallus
Domestic chicken
Ggal\MSI2
Gallus gallus
Domestic chicken
Ggal\HNRNPD
Gallus gallus
Domestic chicken
Ggal\MSI2
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000028932
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (34)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Hrb87F
8 of 10
Rb97D
8 of 10
Rbp4
4 of 10
Hrb27C
3 of 10
Rbp6
3 of 10
SLIRP2
3 of 10
sqd
3 of 10
CG5213
2 of 10
CG34354
2 of 10
msi
2 of 10
Secp43
2 of 10
SLIRP1
2 of 10
ssx
2 of 10
tra2
2 of 10
bol
1 of 10
Caper
1 of 10
CG2931
1 of 10
CG3335
1 of 10
CG4612
1 of 10
CG7903
1 of 10
CG11726
1 of 10
CG12288
1 of 10
CG33278
1 of 10
CG34334
1 of 10
CG42458
1 of 10
cocoon
1 of 10
eIF4B
1 of 10
eIF4H1
1 of 10
eIF4H2
1 of 10
Larp7
1 of 10
Sxl
1 of 10
Syp
1 of 10
TBPH
1 of 10
trv
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 2 )
Potential Models Based on Orthology ( 3 )
Modifiers Based on Experimental Evidence ( 4 )
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
HNRNPA2B1; heterogeneous nuclear ribonucleoprotein A2/B1
12 of 15
600124
 
HNRNPA1; heterogeneous nuclear ribonucleoprotein A1
9 of 15
164017
 
HNRNPA1L2; heterogeneous nuclear ribonucleoprotein A1 like 2
9 of 15
      HNRNPA3; heterogeneous nuclear ribonucleoprotein A3
      9 of 15
      605372
          HNRNPA0; heterogeneous nuclear ribonucleoprotein A0
          5 of 15
          609409
              Functional Complementation Data
              Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
              Interactions
              Summary of Physical Interactions
              esyN Network Diagram
              Show neighbor-neighbor interactions:
              Select Layout:
              Legend:
              Protein
              RNA
              Selected Interactor(s)
              Interactions Browser
              View in Interactions Browser
              Please see the Physical Interaction reports below for full details
              protein-protein
              Physical Interaction
              Assay
              References
              Hrb98DE - CG9106
              two hybrid
              (Hu et al., 2017.6.13)
              Hrb98DE - Hrb27C
              pull down, autoradiography
              (Horan et al., 2015)
              Hrb98DE - Hrb87F
              experimental knowledge based
              (Guruharsha et al., 2011)
              Hrb98DE - InR
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              Hrb98DE - Nca
              two hybrid
              (Hu et al., 2017.6.13)
              Hrb98DE - PGRP-LB
              experimental knowledge based
              (Guruharsha et al., 2011)
              Hrb98DE - Parp
              anti tag coimmunoprecipitation, western blot
              (Ji and Tulin, 2009)
              Hrb98DE - Pi3K21B
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              Hrb98DE - S6kII
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              Hrb98DE - Su(var)205
              anti tag coimmunoprecipitation, western blot
              (Tan et al., 2012)
              Hrb98DE - TBPH
              far western blotting, Identification by mass spectrometry
              (Romano et al., 2014)
              Hrb98DE - foxo
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              Hrb98DE - gig
              anti tag coimmunoprecipitation, Identification by mass spectrometry
              (Vinayagam et al., 2016)
              Hrb98DE - glo
              experimental knowledge based
              (Guruharsha et al., 2011)
              Hrb98DE - kel
              proximity-dependent biotin identification, Identification by mass spectrometry
              (Mannix et al., 2019)
              Hrb98DE - mrj
              anti tag coimmunoprecipitation, anti tag western blot
              (Li et al., 2016)
              Hrb98DE - sqd
              anti bait coimmunoprecipitation, molecular weight estimation by staining, molecular weight estimation by autoradiography
              (Amero et al., 1993, Matunis et al., 1992)
              RNA-protein
              Physical Interaction
              Assay
              References
              Hrb98DE - Dscam1
              anti bait coimmunoprecipitation, nucleotide sequence identification
              (Olson et al., 2007)
              Hrb98DE - how
              anti bait coimmunoprecipitation, reverse transcription pcr
              (Ji and Tulin, 2016)
              Hrb98DE - lncRNA:Hsrω
              anti tag coimmunoprecipitation, quantitative reverse transcription pcr
              (Ji and Tulin, 2009)
              Hrb98DE - nos
              anti tag coimmunoprecipitation, nucleic acid uv cross-linking assay, tag visualisation, anti bait coimmunoprecipitation, reverse transcription pcr
              (Ji and Tulin, 2016)
              Hrb98DE - pelo
              anti bait coimmunoprecipitation, reverse transcription pcr
              (Ji and Tulin, 2016)
              Hrb98DE - pros
              pull down, Identification by mass spectrometry
              (Borah et al., 2009)
              Hrb98DE - pum
              anti bait coimmunoprecipitation, reverse transcription pcr
              (Ji and Tulin, 2016)
              Hrb98DE - shg
              anti bait coimmunoprecipitation, quantitative reverse transcription pcr, electrophoretic mobility shift assay, tag visualisation, reverse transcription pcr, nucleic acid uv cross-linking assay
              (Ji and Tulin, 2016, Ji and Tulin, 2012)
              Hrb98DE - shu
              anti bait coimmunoprecipitation, reverse transcription pcr
              (Ji and Tulin, 2016)
              RNA-RNA
              Physical Interaction
              Assay
              References
              Hrb98DE - mir-1
              luminiscence technology
              (King et al., 2011)
              Summary of Genetic Interactions
              esyN Network Diagram
              esyN Network Key:
              Suppression
              Enhancement
              View in Interactions Browser
              Please look at the allele data for full details of the genetic interactions
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              Hrb98DE
              suppressible
              mrj
              (Li et al., 2016)
              Hrb98DE
              enhanceable
              Parg
              (Ji and Tulin, 2012)
              Hrb98DE
              suppressible
              shg
              (Ji and Tulin, 2012)
              Hrb98DE|Parg
              suppressible
              shg
              (Ji and Tulin, 2012)
              Hrb98DE
              enhanceable
              TBPH
              (Romano et al., 2014)
              Starting gene(s)
              Interaction type
              Interacting gene(s)
              Reference
              TBPH
              enhanceable
              Hrb98DE
              (Romano et al., 2014)
              TBPH
              suppressible
              Hrb98DE
              (Appocher et al., 2017)
              External Data
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Pathways
              Signaling Pathways (FlyBase)
              Metabolic Pathways
              External Data
              Linkouts
              KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              Genomic Location and Detailed Mapping Data
              Chromosome (arm)
              3R
              Recombination map

              3-96

              Cytogenetic map
              98D6-98D6
              Sequence location
              3R:28,599,834..28,605,777 [+]
              FlyBase Computed Cytological Location
              Cytogenetic map
              Evidence for location
              98D6-98D6
              Limits computationally determined from genome sequence between P{PZ}l(3)0648706487 and P{EP}EP3390EP3390
              Experimentally Determined Cytological Location
              Cytogenetic map
              Notes
              References
              98D-98E
              (determined by in situ hybridisation)
              (Matunis et al., 1992, Haynes et al., 1991, Haynes et al., 1990, Haynes et al., 1987)
              Experimentally Determined Recombination Data
              Location

              3-96

              (FlyBase, 2016)

              3-93.8

              (Comeron et al., 2012)
              Left of (cM)
              Right of (cM)
              Notes
              Stocks and Reagents
              Stocks (18)
              Genomic Clones (17)
               

              Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

              cDNA Clones (373)
               

              Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

              cDNA clones, fully sequenced
              BDGP DGC clones
              Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               

              monoclonal

              (Li et al., 2016, Matunis et al., 1992)

              polyclonal

              (Blanchette et al., 2009, Borah et al., 2009)
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of
              Source for database merge of
              Additional comments
              Other Comments

              Area matching Drosophila hnRNP gene Acc. No. M28870.

              (Davies, 2001.3.15)

              The relationship between the mutationally defined genes in the 98D region (l(3)98Da, l(3)98Dh, l(3)98Di, l(3)98Dj, l(3)98Dc, l(3)98Dd, l(3)98Dk and l(3)98Dm) and molecularly defined genes (anon-98Da, anon-98Db, anon-98Dc, anon-98Dd, dfk and Hrb98DE) has not yet been determined.

              (Cass, 1997.7.17)

              The consequences of HRB overexpression and absence in living flies is examined.

              (Zu et al., 1996)

              Complete deletion of Hrb87F has no obvious defect on viability or fertility, but when in combined with hypodosage of Hrb98DE leads to reduced male and female fertility.

              (Haynes et al., 1995)

              Overexpression of Hrb98DE leads to skipping of all internal exons in the Ddc pre-mRNA in vivo, regardless of the normal Ddc splice site choice. These results indicate Hrb98DE has a splicing activity that promotes the use of terminal splice sites.

              (Shen et al., 1995)

              An Hrb98DE cDNA clone has been isolated and sequenced.

              (Matunis et al., 1992)

              Hrb98DE has been cloned and sequenced. Eight transcripts, which can generate four protein isoforms, are produced by the use of alternative exons and splice acceptor sites.

              (Haynes et al., 1990)

              Transcription unit defined during molecular analysis of the fkh gene region.

              (Weigel et al., 1989)

              Isolated from a pupal cDNA library, using a fragment of the fs(1)h coding region containing "pen" repetitive sequences (GGN, where N is any nucleotide) as the probe.

              (Haynes et al., 1987)

              A Hrb98DE cDNA has been cloned and sequenced. The predicted amino acid sequence has strong homology to a rat single-stranded nucleic acid binding protein.

              (Haynes et al., 1987)

              This gene was also isolated by Knust et al. (1987) as a clone that cross-hybridized to a Delta probe.

              Origin and Etymology
              Discoverer
              Etymology
              Identification
              External Crossreferences and Linkouts ( 72 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              modMine - A data warehouse for the modENCODE project
              Linkouts
              BioGRID - A database of protein and genetic interactions.
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FLIGHT - Cell culture data for RNAi and other high-throughput technologies
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              FlyMine - An integrated database for Drosophila genomics
              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
              KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
              MIST (protein-protein) - An integrated Molecular Interaction Database
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              Synonyms and Secondary IDs (20)
              Reported As
              Symbol Synonym
              CG9983
              (Kolkhof et al., 2017, Brooks et al., 2015, Horan et al., 2015, Hosono et al., 2015, Rosa-Ferreira et al., 2015, Ellis and Carney, 2011, Ni et al., 2010.12.1, Ji and Tulin, 2009, Pisa et al., 2009, Andersen and Tapon, 2008, Ni et al., 2008, Quinones-Coello, 2007, Huang et al., 2005, Whitfield, 2000.4.28, Whitfield, 2000.5.9)
              E7Δ6
              (Weigel et al., 1989)
              HDP(P9)
              (Voelker et al., 1991)
              HRB98DE
              (Kim et al., 2013, Sofola et al., 2007)
              HRB98DE/hrp38
              (Beyer et al., 1996)
              Hrb1
              Hrb98 de
              (Sofola et al., 2007)
              Hrb98DE
              (Fingerhut et al., 2019, Foley et al., 2019, Mannix et al., 2019, Raza et al., 2019, Zhang et al., 2018, Hu et al., 2017.6.13, Ishiguro et al., 2017, Clandinin and Owens, 2016-, Ji and Tulin, 2016, Kuleesha et al., 2016, Lee et al., 2016, Li et al., 2016, Zhang et al., 2016, Angrisani et al., 2015, Brooks et al., 2015, Gene Disruption Project members, 2015-, Horan et al., 2015, Khan et al., 2015, Nagarkar-Jaiswal et al., 2015, Ugrankar et al., 2015, He et al., 2014, Lowe et al., 2014, Romano et al., 2014, Yan et al., 2014, Kim et al., 2013, Kwon et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Tan et al., 2012, Ellis and Carney, 2011, Friedman et al., 2011, Napoletano et al., 2011, Pisa et al., 2009, Zhou et al., 2008, Buszczak et al., 2007, Curtis et al., 2007, Pinnola et al., 2007, Quinones-Coello, 2007, Sofola et al., 2007, Jolly and Lakhotia, 2006)
              Hrb98DE/Hrp38
              (Ji et al., 2013)
              Hrp38
              (Ustaoglu et al., 2019, Appocher et al., 2017, Ji and Tulin, 2016, Romano et al., 2014, Ji et al., 2013, Venables et al., 2012)
              Pen9
              anon-E7Δ6
              hnRNP A2/B1
              (Tan et al., 2012)
              hrb98 de
              (Sofola et al., 2007)
              hrb98DE
              (Mao et al., 2016, King et al., 2011, Clyne et al., 2003)
              hrp38
              (Horan et al., 2015, Ji and Tulin, 2012, Venables et al., 2012, Blanchette et al., 2009, Borah et al., 2009, Ji and Tulin, 2009, Olson et al., 2007, Sofola et al., 2007, Amero et al., 1993, Matunis et al., 1992, Matunis et al., 1992)
              p9
              (Haynes et al., 1987)
              Name Synonyms
              Heterogeneous nuclear ribonucleoprotein at 98DE
              (Pisa et al., 2009)
              hnRNA-binding protein 1
              s
              (Jolly and Lakhotia, 2006)
              Secondary FlyBase IDs
              • FBgn0003056
              • FBgn0014945
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              References (138)