FB2021_01, released Feb 18, 2021

Gene: Dmel\Hsc70-1

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General Information
Symbol
Dmel\Hsc70-1
Species
D. melanogaster
Name
Heat shock protein cognate 1
Annotation Symbol
CG8937
Feature Type
protein_coding_gene
FlyBase ID
FBgn0001216
Gene Model Status
Current
Stock Availability
4 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Also Known As

Hsc70, Hsc1

Key Links
Genomic Location
Cytogenetic map
70C9-70C9
Sequence location
3L:13,974,061..13,977,761 [+]
Recombination map

3-41

RefSeq locus
NT_037436 REGION:13974061..13977761
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (15 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
enables ATP binding
inferred from biological aspect of ancestor with PANTHER:PTN002321897
(assigned by GO_Central )
(Gaudet et al., 2011)
enables ATPase activity
inferred from sequence or structural similarity with UniProtKB:P10591
(FlyBase Curators, 2008--)
inferred from biological aspect of ancestor with PANTHER:PTN002321897
(assigned by GO_Central )
(Gaudet et al., 2011)
enables heat shock protein binding
inferred from biological aspect of ancestor with PANTHER:PTN002321897
(assigned by GO_Central )
(Gaudet et al., 2011)
enables misfolded protein binding
inferred from biological aspect of ancestor with PANTHER:PTN002321897
(assigned by GO_Central )
(Gaudet et al., 2011)
enables protein folding chaperone
inferred from biological aspect of ancestor with PANTHER:PTN002321897
(assigned by GO_Central )
(Gaudet et al., 2011)
enables unfolded protein binding
inferred from biological aspect of ancestor with PANTHER:PTN002321897
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (5 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
involved_in cellular response to unfolded protein
inferred from biological aspect of ancestor with PANTHER:PTN002321897
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in chaperone cofactor-dependent protein refolding
inferred from biological aspect of ancestor with PANTHER:PTN002321897
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in protein folding
inferred from sequence or structural similarity with UniProtKB:P10591
(FlyBase Curators, 2008--)
involved_in protein refolding
inferred from biological aspect of ancestor with PANTHER:PTN002321897
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in vesicle-mediated transport
inferred from biological aspect of ancestor with PANTHER:PTN002500132
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
located_in cytoplasm
inferred from sequence or structural similarity with UniProtKB:P10591
(FlyBase Curators, 2008--)
inferred from biological aspect of ancestor with PANTHER:PTN002321897
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in cytosol
inferred from biological aspect of ancestor with PANTHER:PTN002500132
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in nucleus
inferred from sequence or structural similarity with UniProtKB:P10591
(FlyBase Curators, 2008--)
inferred from biological aspect of ancestor with PANTHER:PTN002500132
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN002500132
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the heat shock protein 70 family. (P29843)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
HEAT SHOCK PROTEIN 70 CHAPERONES -
The Heat Shock Protein 70 (Hsp70) superfamily of chaperones assist in numerous folding processes and are upregulated by heat stress and toxic chemicals. Hsp70 chaperones share a highly conserved bipartite domain structure composed of an ATPase domain and a substrate-binding domain. (Adapted from PMID:17441502, FBrf0232269 and FBrf0174945).
SPLICEOSOME COMPLEX C -
Nuclear pre-mRNA splicing is catalyzed by the spliceosome which assembles in a step-wise manner. Complex B undergoes a number of structural rearrangements and U4 and U1 snRNPs dissociate to generate complex C, the catalytic spliceosome. (Adapted from PMID:24452469 and PMID:23118483).
SPLICEOSOME COMPLEX P -
Nuclear pre-mRNA splicing is catalyzed by the spliceosome which assembles in a step-wise manner. Complex P, the post-spliceosomal complex, is formed after the catalytic removal of the intron by complex C. Complex P contains the lariat intron and spliced exons. (Adapted from PMID:24452469 and PMID:23118483).
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Hsc70-1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Hsc70-1-RA
FBtr0075762
NM_079339
2168
641
Hsc70-1-RC
FBtr0075761
NM_168568
2611
555
Hsc70-1-RD
FBtr0075763
NM_168569
2543
555
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Hsc70-1-PA
FBpp0075504
70.7
641
5.14
NP_524063
AAF49782
Hsc70-1-PC
FBpp0075503
61.3
555
5.10
NP_729940
AAN11819
Hsc70-1-PD
FBpp0075505
61.3
555
5.10
NP_729941
AAN11820
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

555 aa isoforms: Hsc70-1-PC, Hsc70-1-PD
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hsc70-1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Hsc70-1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 1 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Hsc70-1
Transgenic constructs containing regulatory region of Hsc70-1
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation
Inferred from location
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (20)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\HSPA8
9 of 15
Yes
No
1  
Hsap\HSPA2
8 of 15
No
Yes
Hsap\HSPA1B
7 of 15
No
No
Hsap\HSPA6
7 of 15
No
Yes
Hsap\HSPA1L
6 of 15
No
No
9  
Hsap\HSPA1A
5 of 15
No
No
3  
Hsap\HSPA5
4 of 15
No
No
Hsap\HSPA9
3 of 15
No
No
4  
Hsap\HSPA7
2 of 15
No
Yes
Hsap\HSPA13
2 of 15
No
Yes
Hsap\ANKRD45
1 of 15
No
Yes
Hsap\HSPA4
1 of 15
No
No
1  
Hsap\HSPA4L
1 of 15
No
No
1  
Hsap\HSPA12A
1 of 15
No
No
Hsap\HSPA12B
1 of 15
No
No
Hsap\HSPA14
1 of 15
No
No
Hsap\HSPH1
1 of 15
No
No
1  
Hsap\HYOU1
1 of 15
No
No
1  
Hsap\NKX2-6
1 of 15
No
No
Hsap\SLC9C2
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (16)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Hspa1a
8 of 15
Yes
No
Mmus\Hspa8
8 of 15
Yes
No
Mmus\Hspa1b
7 of 15
No
No
Mmus\Hspa1l
7 of 15
No
No
Mmus\Hspa2
7 of 15
No
Yes
Mmus\Hspa5
3 of 15
No
No
Mmus\Hspa9
3 of 15
No
No
Mmus\Hspa13
2 of 15
No
Yes
Mmus\Ankrd45
1 of 15
No
Yes
Mmus\Hspa4l
1 of 15
No
No
Mmus\Hspa4
1 of 15
No
No
Mmus\Hspa12a
1 of 15
No
No
Mmus\Hspa12b
1 of 15
No
No
Mmus\Hspa14
1 of 15
No
No
Mmus\Hsph1
1 of 15
No
No
Mmus\Hyou1
1 of 15
No
No
Rattus norvegicus (Norway rat) (19)
Rnor\Hspa2
7 of 13
Yes
Yes
Rnor\Hspa8
7 of 13
Yes
No
Rnor\Hspa1l
5 of 13
No
No
Rnor\Hspa5
4 of 13
No
No
Rnor\Hspa1a
3 of 13
No
No
Rnor\Hspa9
3 of 13
No
No
Rnor\Hspa1b
2 of 13
No
No
Rnor\LOC689955
2 of 13
No
Yes
Rnor\LOC108348108
2 of 13
No
No
Rnor\Hspa4l
1 of 13
No
No
Rnor\Hspa4
1 of 13
No
No
Rnor\Hspa12a
1 of 13
No
No
Rnor\Hspa12b
1 of 13
No
No
Rnor\Hspa13
1 of 13
No
Yes
Rnor\Hspa14
1 of 13
No
No
Rnor\Hsph1
1 of 13
No
No
Rnor\Hyou1
1 of 13
No
No
Rnor\LOC680121
1 of 13
No
No
Rnor\LOC100912578
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (16)
Xtro\hsp70
7 of 12
Yes
No
Xtro\hspa1b
6 of 12
No
Yes
Xtro\hspa1l
6 of 12
No
Yes
Xtro\hspa2
6 of 12
No
Yes
Xtro\hspa8
6 of 12
No
Yes
Xtro\hspa1a
5 of 12
No
No
Xtro\hspa5
3 of 12
No
No
Xtro\hspa9
3 of 12
No
No
Xtro\hspa13
2 of 12
No
Yes
Xtro\ankrd45
1 of 12
No
Yes
Xtro\hspa4
1 of 12
No
No
Xtro\hspa12a
1 of 12
No
Yes
Xtro\hspa12b
1 of 12
No
No
Xtro\hspa14
1 of 12
No
No
Xtro\hsph1
1 of 12
No
No
Xtro\hyou1
1 of 12
No
No
Danio rerio (Zebrafish) (22)
Drer\hsp70.3
8 of 15
Yes
No
Drer\hspa8
8 of 15
Yes
No
Drer\si:ch211-199o1.2
8 of 15
Yes
No
Drer\hsc70
7 of 15
No
No
Drer\hsp70l
6 of 15
No
Yes
0  
Drer\si:dkey-4p15.3
6 of 15
No
No
Drer\hsp70.2
5 of 15
No
No
Drer\hsp70.1
4 of 15
No
Yes
Drer\hspa5
4 of 15
No
No
Drer\hspa9
3 of 15
No
No
Drer\hspa13
2 of 15
No
Yes
Drer\ankrd45
1 of 15
No
Yes
Drer\hspa4a
1 of 15
No
No
Drer\hspa4b
1 of 15
No
No
Drer\hspa4l
1 of 15
No
No
Drer\hspa8l
1 of 15
No
Yes
Drer\hspa12a
1 of 15
No
No
Drer\hspa14
1 of 15
No
No
Drer\hsph1
1 of 15
No
No
Drer\hyou1
1 of 15
No
No
Drer\si:ch211-250m6.2
1 of 15
No
Yes
Drer\si:dkey-61p9.6
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (11)
Cele\hsp-1
9 of 15
Yes
No
Cele\F44E5.4
4 of 15
No
Yes
Cele\F44E5.5
4 of 15
No
No
Cele\hsp-70
4 of 15
No
No
Cele\hsp-3
3 of 15
No
No
Cele\hsp-4
3 of 15
No
No
Cele\hsp-6
3 of 15
No
No
Cele\F11F1.1
2 of 15
No
Yes
Cele\stc-1
2 of 15
No
Yes
Cele\T14G8.3
1 of 15
No
No
Cele\T24H7.2
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (14)
Atha\AT3G09440
9 of 9
Yes
Yes
Atha\ERD2
8 of 9
No
Yes
Atha\HSC70-1
8 of 9
No
No
Atha\Hsp70-2
8 of 9
No
Yes
Atha\HSP70
8 of 9
No
Yes
Atha\Hsp70b
8 of 9
No
Yes
Atha\BIP1
2 of 9
No
No
Atha\BIP2
2 of 9
No
No
Atha\BIP3
2 of 9
No
No
Atha\HSP70T-2
2 of 9
No
Yes
Atha\cpHsc70-1
1 of 9
No
No
Atha\cpHsc70-2
1 of 9
No
No
Atha\mtHsc70-1
1 of 9
No
No
Atha\MTHSC70-2
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (14)
Scer\SSA2
11 of 15
Yes
No
Scer\SSA1
10 of 15
No
Yes
Scer\SSA3
10 of 15
No
Yes
Scer\SSA4
10 of 15
No
No
Scer\SSB1
6 of 15
No
Yes
Scer\SSB2
6 of 15
No
Yes
Scer\KAR2
3 of 15
No
No
Scer\ECM10
2 of 15
No
No
Scer\LHS1
2 of 15
No
No
Scer\SSC1
2 of 15
No
No
Scer\SSQ1
2 of 15
No
No
Scer\SSE1
1 of 15
No
No
Scer\SSE2
1 of 15
No
No
Scer\SSZ1
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (6)
Spom\ssa1
9 of 12
Yes
No
Spom\ssa2
9 of 12
Yes
No
Spom\sks2
4 of 12
No
Yes
Spom\bip1
2 of 12
No
No
Spom\lsh1
1 of 12
No
No
Spom\ssc1
1 of 12
No
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091904NJ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00004023
Drosophila simulans
Dsim\GD14466
Drosophila sechellia
Dsec\GM25439
Drosophila erecta
Dere\GG15660
Drosophila yakuba
Dyak\GE21989
Drosophila ananassae
Dana\GF24052
Drosophila pseudoobscura pseudoobscura
Dpse\GA23772
Drosophila persimilis
Dper\GL15719
Drosophila willistoni
Dwil\GK20316
Drosophila virilis
Dvir\GJ11309
Drosophila mojavensis
Dmoj\GI11627
Drosophila grimshawi
Dgri\GH14643
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502RJ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17017108
Musca domestica
House fly
Mdoa\17020123
Glossina morsitans
Tsetse fly
Gmor\GMOY012049
Glossina morsitans
Tsetse fly
Gmor\GMOY004286
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_14242
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_00809
Mayetiola destructor
Hessian fly
Mdes\Mdes007256
Mayetiola destructor
Hessian fly
Mdes\Mdes007255
Anopheles darlingi
American malaria mosquito
Adar\ADAC010350
Anopheles darlingi
American malaria mosquito
Adar\ADAC005135
Anopheles gambiae
Malaria mosquito
Agam\AGAP002076
Anopheles gambiae
Malaria mosquito
Agam\AGAP004944
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ008915
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ006534
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W02J2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA002428
Bombyx mori
Silkmoth
Bmor\BGIBMGA014536
Bombyx mori
Silkmoth
Bmor\BmHSC70-4
Danaus plexippus
Monarch butterfly
Dple\DPOGS208954-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS210048-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS213900-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS212775-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS213925-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS210250-PA
Heliconius melpomene
Postman butterfly
Hmel\Hem
Heliconius melpomene
Postman butterfly
Hmel\HMEL010425
Heliconius melpomene
Postman butterfly
Hmel\HMEL014657
Heliconius melpomene
Postman butterfly
Hmel\HMEL014163
Heliconius melpomene
Postman butterfly
Hmel\HMEL006064
Apis florea
Little honeybee
Aflo\2484227444
Apis florea
Little honeybee
Aflo\2994796276
Apis florea
Little honeybee
Aflo\2354233092
Apis mellifera
Western honey bee
Amel\LOC410620
Apis mellifera
Western honey bee
Amel\GB50246
Apis mellifera
Western honey bee
Amel\Hsc70-4
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP16151
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP14904
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25428
Bombus terrestris
Buff-tailed bumblebee
Bter\15203980
Bombus terrestris
Buff-tailed bumblebee
Bter\15207411
Bombus terrestris
Buff-tailed bumblebee
Bter\15209666
Linepithema humile
Argentine ant
Lhum\LH12354
Linepithema humile
Argentine ant
Lhum\LH21302
Linepithema humile
Argentine ant
Lhum\LH21803
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001e42
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002430
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002c83
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001ed9
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG008319
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG002344
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG002830
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG007999
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003712
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG002346
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_11145
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06831
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06803
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_01683
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06804
Tribolium castaneum
Red flour beetle
Tcas\TC033493
Tribolium castaneum
Red flour beetle
Tcas\TC010172
Tribolium castaneum
Red flour beetle
Tcas\TC031639
Tribolium castaneum
Red flour beetle
Tcas\hsp68b
Tribolium castaneum
Red flour beetle
Tcas\Hem
Tribolium castaneum
Red flour beetle
Tcas\TC000188
Pediculus humanus
Human body louse
Phum\PHUM126800
Pediculus humanus
Human body louse
Phum\PHUM333930
Pediculus humanus
Human body louse
Phum\PHUM588610
Pediculus humanus
Human body louse
Phum\PHUM018540
Rhodnius prolixus
Kissing bug
Rpro\RPRC004310
Rhodnius prolixus
Kissing bug
Rpro\RPRC009759
Rhodnius prolixus
Kissing bug
Rpro\RPRC012193
Cimex lectularius
Bed bug
Clec\CLEC002869
Cimex lectularius
Bed bug
Clec\CLEC002762
Cimex lectularius
Bed bug
Clec\CLEC010952
Cimex lectularius
Bed bug
Clec\CLEC025196
Cimex lectularius
Bed bug
Clec\CLEC010950
Cimex lectularius
Bed bug
Clec\CLEC005841
Cimex lectularius
Bed bug
Clec\CLEC025196-PB
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007961
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000474
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000903
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001597
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI080190
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008763
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004809
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI067751
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI073873
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI080139
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_05273
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_04366
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_06862
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X02GG )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR004960
Strigamia maritima
European centipede
Smar\SMAR013707
Strigamia maritima
European centipede
Smar\SMAR004796
Ixodes scapularis
Black-legged tick
Isca\ISCW009279
Ixodes scapularis
Black-legged tick
Isca\ISCW024910
Ixodes scapularis
Black-legged tick
Isca\ISCW017456
Ixodes scapularis
Black-legged tick
Isca\ISCW011425
Stegodyphus mimosarum
African social velvet spider
Smim\KFM80380.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM78034.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM83474.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM76829.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM83484.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM78035.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM69762.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM83486.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM57777.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM69761.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g03320
Tetranychus urticae
Two-spotted spider mite
Turt\tetur11g01700
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g03330
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_227800
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_302856
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_303127
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_256736
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G03SF )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hsp701E
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hsp701C
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hsp701A
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hsp701D
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hsp703A
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hsp701B
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Nckap1_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Nckap1
Ciona intestinalis
Vase tunicate
Cint\LOC100187210
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000003184
Ciona intestinalis
Vase tunicate
Cint\hsp70
Gallus gallus
Domestic chicken
Ggal\NCKAP1
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000027417
Gallus gallus
Domestic chicken
Ggal\HSP70
Gallus gallus
Domestic chicken
Ggal\HSPA8
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (14)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Hsc70-4
8 of 10
Hsc70-2
6 of 10
Hsc70-3
6 of 10
Hsp68
6 of 10
Hsp70Aa
6 of 10
Hsp70Ba
6 of 10
Hsp70Bbb
6 of 10
Hsc70-5
5 of 10
Hsp70Ab
5 of 10
Hsp70Bb
5 of 10
Hsp70Bc
5 of 10
CG7182
3 of 10
CG2918
2 of 10
Hsc70Cb
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    Hsc70-1GD13532
    ameliorates  Machado-Joseph disease
    modeled by Hsap\ATXN3tr.Q78.UAS.Tag:HA
    (Voßfeldt et al., 2012)
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    HSPA8; heat shock protein family A (Hsp70) member 8
    9 of 15
    600816
         
        HSPA2; heat shock protein family A (Hsp70) member 2
        8 of 15
        140560
            HSPA1B; heat shock protein family A (Hsp70) member 1B
            7 of 15
            603012
                HSPA6; heat shock protein family A (Hsp70) member 6
                7 of 15
                140555
                    HSPA1L; heat shock protein family A (Hsp70) member 1 like
                    6 of 15
                    140559
                         
                        HSPA1A; heat shock protein family A (Hsp70) member 1A
                        5 of 15
                        140550
                             
                            HSPA5; heat shock protein family A (Hsp70) member 5
                            4 of 15
                            138120
                                HSPA9; heat shock protein family A (Hsp70) member 9
                                3 of 15
                                600548
                                 
                                Functional Complementation Data
                                Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                Interactions
                                Summary of Physical Interactions
                                Summary of Genetic Interactions
                                esyN Network Diagram
                                Starting gene(s)
                                Interaction type
                                Interacting gene(s)
                                Reference
                                Starting gene(s)
                                Interaction type
                                Interacting gene(s)
                                Reference
                                External Data
                                Linkouts
                                DroID - A comprehensive database of gene and protein interactions.
                                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                MIST (protein-protein) - An integrated Molecular Interaction Database
                                Pathways
                                Genomic Location and Detailed Mapping Data
                                Chromosome (arm)
                                3L
                                Recombination map

                                3-41

                                Cytogenetic map
                                70C9-70C9
                                Sequence location
                                3L:13,974,061..13,977,761 [+]
                                FlyBase Computed Cytological Location
                                Cytogenetic map
                                Evidence for location
                                70C9-70C9
                                Limits computationally determined from genome sequence between P{EP}EP3561EP3561 and P{PZ}l(3)70Da02402&P{PZ}btl00208
                                Experimentally Determined Cytological Location
                                Cytogenetic map
                                Notes
                                References
                                Experimentally Determined Recombination Data
                                Location

                                3-41

                                (FlyBase, 2016)

                                3-35.4

                                (Comeron et al., 2012)
                                Left of (cM)
                                Right of (cM)
                                Notes
                                Stocks and Reagents
                                Stocks (4)
                                Genomic Clones (19)
                                cDNA Clones (52)
                                 

                                Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                                cDNA clones, fully sequenced
                                BDGP DGC clones
                                Other clones
                                Drosophila Genomics Resource Center cDNA clones

                                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                cDNA Clones, End Sequenced (ESTs)
                                BDGP DGC clones
                                Other clones
                                RNAi and Array Information
                                Linkouts
                                DRSC - Results frm RNAi screens
                                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                Antibody Information
                                Laboratory Generated Antibodies
                                 
                                Commercially Available Antibodies
                                 
                                Other Information
                                Relationship to Other Genes
                                Source for database identify of

                                Source for identity of: Hsc70-1 CG8937

                                (Bayraktaroglu, 1999.11)
                                Source for database merge of

                                Source for merge of: Hsc70-1 BcDNA:RH49358

                                (FlyBase, 1996-)
                                Additional comments

                                Source for merge of Hsc70-1 BcDNA:RH49358 was a shared cDNA ( date:030728 ).

                                (FlyBase, 1996-)
                                Other Comments

                                Members of the hsc70 gene family (heat shock cognate genes) that reside within the same intracellular compartment in different organisms share greater amino acid identity than hsc70 proteins from the same organism but different organelles. This pattern of conservation indicates specialisation of hsc70 function.

                                (Rubin et al., 1993)

                                transcript abundance embryo: \+ transcript abundance larva: \- transcript abundance adult: ++ the codon specifying amino acid 66 is interrupted by an 1.7 kb insertion

                                First recognised by sequence similarity to Hsp70. Transcription is developmentally regulated, but is temperature independent.

                                Origin and Etymology
                                Discoverer
                                Etymology
                                Identification
                                External Crossreferences and Linkouts ( 69 )
                                Sequence Crossreferences
                                NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                Other crossreferences
                                Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                Flygut - An atlas of the Drosophila adult midgut
                                GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                                iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                                InterPro - A database of protein families, domains and functional sites
                                KEGG Genes - Molecular building blocks of life in the genomic space.
                                modMine - A data warehouse for the modENCODE project
                                Linkouts
                                DPiM - Drosophila Protein interaction map
                                DroID - A comprehensive database of gene and protein interactions.
                                DRSC - Results frm RNAi screens
                                FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                                FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                FlyMine - An integrated database for Drosophila genomics
                                InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                                KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                                MIST (protein-protein) - An integrated Molecular Interaction Database
                                Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                Synonyms and Secondary IDs (19)
                                Datasets (0)
                                Study focus (0)
                                Experimental Role
                                Project
                                Project Type
                                Title
                                References (95)