Gene Dmel\Hsc70-6

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General Information

Symbol

Dmel\Hsc70-6

Species

D. melanogaster

Name

Heat shock protein cognate 6

Annotation symbol

Feature type

gene

FlyBase ID

FBgn0001221

Gene Model Status

Unannotated

Stock availability

None publicly available

Also Known As

Hsc70

Genomic Location

Chromosome (arm)

Recombination map

1-[14]

Cytogenetic map

5C-5C

Sequence location

Summary Information

Automatically generated summary

See sections below for more information

The gene Heat shock protein cognate 6 is referred to in FlyBase by the symbol Dmel\Hsc70-6 (FBgn0001221). It is a gene from Drosophila melanogaster. Its molecular function is unknown. Based on sequence similarity, it is predicted to be involved in the biological process: protein folding. No alleles are reported. It has no annotated transcripts. Gene has not been localized to the genome sequence.

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2012_01

FB2011_10

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

5C-5C

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-[14]

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Mapped Features

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Notes

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Notes

High-Throughput Expression Data

Expression Clusters

External Data & Images

Linkouts

Alleles & Phenotypes

Summary of Allele Phenotypes

Phenotype manifest in

Allele

Classical Alleles ( 0 )

For All Classical Alleles Show

Allele of Hsc70-6	Class	Mutagen	Stocks	Known lesion

Alleles Carried on Transgenic Constructs ( 0 )

For All Alleles Carried on Transgenic Constructs Show

Allele of Hsc70-6	Class	Mutagen	Stocks	Known lesion

Aneuploid Aberrations

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

Insertions

Type of insertions

Name

Expression data

Gene Ontology: Function, Process & Cellular Component ( 1 unique term )

Terms Based on Experimental Evidence ( 0 terms )

Terms Based on Predictions or Assertions ( 1 term )

Molecular Function ( 0 terms)

Biological Process

CV term

Evidence

References

protein folding

inferred from sequence or structural similarity with Saccharomyces SSE1

(FlyBase, 1992-)

Cellular Component ( 0 terms)

Sequence Ontology: Class of Gene

gene

Interactions & Pathways

Summary of Physical Interactions

Protein-protein

Interacting group

Assay

References

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

Hsc70-6 allele

Gene

References

External Data

Linkouts

Orthologs

Genome-wide drosophilid orthologs

Curated drosophilid orthologs

Linkouts

Stocks & Reagents

Stocks Listed in FlyBase ( 0 )

Genomic Clones ( 0 )

cDNA Clones ( 0 )

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

5656927

Antibody Information

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

Other Comments

External Crossreferences & Linkouts

Sequence Crossreferences

Other Crossreferences

Linkouts

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

5656927

Synonyms & Secondary IDs ( 9 )

Reported As

Symbol Synonym

dhsc70

(Rabindran et al., 1994)

hsc6

(Shopland and Lis, 1996)

Hsc6

Hsc70

(Wellington and Zinsmaier, 2005, Tatar et al., 2003, Yue et al., 1999, Wilke et al., 1994)

HSC-70

(Richmond and Broadie, 2002)

HSC70

(Gunawardena et al., 2003, Singh and Lakhotia, 1995, Folk et al., 2006)

hsc70

(Mehta et al., 1995, Mehta et al., 1991, Ornelles and Penman, 1990)

Hsc70-6

Name Synonym

Heat shock protein cognate 6

Secondary FlyBase IDs

References ( 14 )

Research paper

Folk et al., 2006, J. exp. Biol. 209(Pt 20): 3964--3973: Selection on knockdown performance in Drosophila melanogaster impacts thermotolerance and heat-shock response differently in females and males. [FBrf0192281]
Yue et al., 1999, Genetics 151(3): 1065--1079: Genetic analysis of viable hsp90 alleles reveals a critical role in Drosophila spermatogenesis. [FBrf0108102]
Shopland and Lis, 1996, Chromosoma 105(3): 158--171: HSF recruitment and loss at most Drosophila heat shock loci is coordinated and depends on proximal promoter sequences. [FBrf0090797]
Singh and Lakhotia, 1995, Curr. Sci. 69(2): 178--182: The non-induction of HSP70 in heat shocked Malpighian tubules of Drosophila larvae is not due to constitutive presence of HSP70 or HSC70. [FBrf0085945]
Rabindran et al., 1994, Molec. Cell. Biol. 14(10): 6552--6560: Interaction between heat shock factor and hsp70 is insufficient to suppress induction of DNA-binding activity in vivo. [FBrf0076951]
Wilke et al., 1994, Experientia Suppl. 71: 49--59: Effects of alcohol on gene expression in neural cells. [FBrf0074793]
Ornelles and Penman, 1990, J. Cell Sci. 95(3): 393--404: Prompt heat-shock and heat-shifted proteins associated with the nuclear matrix-intermediate filament scaffold in Drosophila melanogaster cells. [FBrf0052268]

Review

Tatar et al., 2003, Science 299(5611): 1346--1351: The endocrine regulation of aging by insulin-like signals. [FBrf0157214]
Richmond and Broadie, 2002, Curr. Opin. Neurobiol. 12(5): 499--507: The synaptic vesicle cycle: exocytosis and endocytosis in Drosophila and C. elegans. [FBrf0151878]

Abstract

Wellington and Zinsmaier, 2005, A. Dros. Res. Conf. 46: 720C: The small glutamine-rich tetratricopeptide containing protein (SGT) is required for neurotransmitter release at Drosophila motor nerve terminals. [FBrf0183618]
Gunawardena et al., 2003, A. Dros. Res. Conf. 44: 115: Molecular motors, cargo vesicles and axonal transport in Huntington's disease. [FBrf0154390]
Mehta et al., 1995, Molec. Biol. Cell 6(Suppl.): 67a: Purification and characterization of DROE1, a Drosophila homolog of bacterial GRPE. [FBrf0085561]
Mehta et al., 1991, J. Cell Biol. 115(3/2): 256a: Purification and properties of Drosophila heat shock cognate proteins. [FBrf0054370]

FlyBase analysis

FlyBase, 1992-, FlyBase curation: FlyBase curation. [FBrf0105495]