A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Gene Dmel\Hsp22

General Information
SymbolDmel\Hsp22SpeciesD. melanogaster
NameHeat shock protein 22Annotation symbolCG4460
Feature typeprotein_coding_geneFlyBase IDFBgn0001223
Gene Model StatusCurrent Stock availability 9 publicly available
Also Known AsCG32041, DmHsp22
Genomic Location
Chromosome (arm)3LRecombination map
Cytogenetic map67B2-67B2Sequence location3L:9,366,031..9,368,064 [+]

Genomic Maps

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Automatically generated summary

See sections below for more information
The gene Heat shock protein 22 is referred to in FlyBase by the symbol Dmel\Hsp22 (CG4460, FBgn0001223). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: determination of adult lifespan; response to oxidative stress; response to heat. 14 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Alpha crystallin/Heat shock protein; Alpha crystallin/Hsp20 domain; HSP20-like chaperone. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed during late pupal stages. This gene is annotated by FlyBase as a dicistronic gene, meaning that some or all of its transcripts encode two or more polypeptide-coding open reading frames (ORFs) , with each ORF assigned to a different gene. The distribution of RNA-Seq coverage data amongst the different encoded genes cannot be determined. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: larval/adult Malpighian tubules, larval salivary gland, adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult crop, larval hindgut, adult heart, larval fat body, adult ovary, adult carcass. Gene sequence location is 3L:9366031..9368064.

User Contributed Data
hide Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage
Hsp22 - Hsp-G3
There are seven closely related heat-shock genes at 67B (Ayme and Tissieres, 1985; Pauli, Arrigo, Vasquez, Tonka, and Tissieres, 1989, Genome 31: 671-76). In addition to the four small heat-shock genes previously identified (Hsp22, Hsp23, Hsp26, and Hsp27), three more genes (Hsp-G1, Hsp-G2, and Hsp-G3, formerly called Gene1, Gene2, and Gene3) have been found clustered within 15 kb of DNA at the same 67B cytological location. All seven genes are heat-shock inducible in almost all cells at the stages tested (Ayme and Tissieres, 1985). The genes are also transcribed during certain developmental stages in the absence of heat shock (Sirotkin and Davidson, 1982, Dev. Biol. 89: 196-210). Pauli et al (1989) report that the maximum accumulation of developmental rRNA in a majority of these small heat-shock genes occurs in the white pupae stage; in Hsp-G2, however, a small transcipt is found in embryos, first and second instar larvae, and young pupae; and a larger transcript in the pupal and adult stages of males (Pauli and Tonka, 1987, J. Mol. Biol. 198: 235-40; Pauli, Tonka, and Ayme-Southgate, 1988, J. Mol. Biol. 200: 47-53). In absence of stress, the expression of Hsp26 has been observed in spermatocytes, nurse cells, epithelium, imaginal discs, proventriculus, and neurocytes (Glaser, Wolfner, and Lis, 1986, EMBO 5: 747-54). Transcripts of Hsp26 and Hsp27 accumulate in adult ovaries, apparently originating in nurse cells (Zimmerman, Petri, and Meselson, 1983, Cell 32: 1161-70).
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Description
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FB2013_03
Transgenic Constructs
P{Hsp22-DsRed.322}
FB2013_02
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
67B2-67B2  
Limits computationally determined from genome sequence between P{PZ}l(3)0162901629&P{PZ}mRpL1210534 and P{EP}Hsp26EP3336&P{EP}Hsp26EP3315  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
67B-67B  
(determined by in situ hybridisation)  
(Corces et al., 1980)
 
A probe containing both Hsp22 and Hsp26 hybridises to cytological locations 67B1--67B2 and 67B4--67B5.  
(Cuenca et al., 1998)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
(Peterson et al., 1979)
Notes
hide Gene Model & Products
Please see the GBrowse view of Dmel\Hsp22 for information on other features GBrowse View Help
To submit a correction to a gene model please use the Contact FlyBase form
detailed view FBtr0076498 FBtr0303475 FBtr0076497 FBtr0303473 FBtr0303474 FBtr0100655 FBtr0100653 FBtr0100558 FBtr0100559 FBtr0076452 FBtr0076496 FBpp0292527 FBpp0076226 FBpp0076225 FBpp0100114 FBpp0292526 FBpp0292525 FBpp0100115 FBpp0100011 FBpp0100010 FBpp0076180 FBpp0076224 FBti0043464 FBti0046959 FBti0070598 FBti0042837 FBti0066366 FBti0045986 FBti0150171 FBti0036591 FBti0045920 FBti0112644 FBti0011419 FBti0105080 FBti0056449 FBti0109742 FBti0039806 FBti0054206 FBti0017718 FBti0069755 FBti0034581
Comments on Gene Model
gene_with_dicistronic_mRNA ; SO:0000722
Gene model reviewed during 5.46
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
Hsp22-RA
FBtr0100558
 NM_001031944
  1900
  174
Hsp22-RB
FBtr0100559
 NM_001031943
  968
  174
Additional Transcript Data & Comments
Reported size (kB)
1.03 (northern blot)
(Corces et al., 1980)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
Hsp22-PA  
FBpp0100010  
19.8  
174  
4.95  
  NP_001027115
  AAF50290
Hsp22-PB  
FBpp0100011  
19.8  
174  
4.95  
  NP_001027114
  AAN11962
Additional Polypeptide Data & Comments
Reported size (kDa)
174 (aa); 19.705 (kD predicted)
(Southgate et al., 1983)
22 (kD observed)
(Craig and McCarthy, 1980)
22.666 (kD predicted)
(Ingolia and Craig, 1982)
Comments
Size determined by in vitro translation.
(Craig and McCarthy, 1980)
External Data
Linkouts
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Alpha crystallin/Heat shock protein (IPR001436)
Alpha crystallin/Hsp20 domain (IPR002068)
HSP20-like chaperone (IPR008978)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AA536253
 
AA536255
 
AE014296
AAF50290
 
AE014296
AAN11962
 
AI257387
 
AI456272
 
AI520460
 
AQ073854
 
AW943326
 
AX093926
 
AX154789
 
AY060412
AAL25451
 
AY119034
AAM50894
 
BE978184
 
BG638118
 
BP550847
 
BP551679
 
CL610262
 
CO156081
 
CO182502
 
CO185064
 
CO300605
 
EC085636
 
EC201226
 
EC264820
 
J01098
AAA28635
 
M13478
 
M29138
 
V00216
 
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
hide Mapped Features
Mapped Features have been reorganized, please see this article for details.
Additional mapped features and mutations can be found on GBrowse or related reports.
Type
Symbol & Location
Additional Notes
References
hide External Data
Linkouts
Crossreferences
EPD - Eukarytoic Promoter Database, an annotated collection of POL II promoters
•
hide Expression Data
hideTranscript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11  
ectoderm | segmentally repeated  
(Leemans et al., 2000)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
prepupal stage  
 
(Pauli et al., 1989)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
hide Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term
Evidence
References
hide Expression Deduced from Reporters
hide High-Throughput Expression Data
Associated Tools
Reference
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
hide FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)


   Styles
   Scales

Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: larval/adult Malpighian tubules, larval salivary gland, adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult crop, larval hindgut, adult heart, larval fat body, adult ovary, adult carcass.
[download data (TSV)]

Guide to FlyAtlas expression level colors
 
 No expression (0 - 9.999)
 
 Low expression (10 - 99.999)
 
 Moderate expression (100 - 499.999)
 
 High level expression (500 - 999.999)
 
 Very high expression (>999.999)

Heatmap
Tissue   Expression Level
Larval Central Nervous System
 
 
Larval Midgut
 
 
Larval Hindgut
 
 
Larval Malpighian Tubules
 
 
Larval Fat Body
 
 
Larval Salivary Gland
 
 
Larval Trachea
 
 
Larval Carcass
 
 
Adult Head
 
 
Adult Eye
 
 
Adult Brain
 
 
Adult Thoracic-Abdominal Ganglion
 
 
Adult Crop
 
 
Adult Midgut
 
 
Adult Hindgut
 
 
Adult Malpighian Tubules
 
 
Adult Fat Body
 
 
Adult Salivary Gland
 
 
Adult Heart
 
 
Adult VirginFemale Spermatheca
 
 
Adult InseminatedFemale Spermatheca
 
 
Adult Ovary
 
 
Adult Testis
 
 
Adult Male Accessory Gland
 
 
Adult Carcass
 
 

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
hide modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)


   Styles
   Scales


[download data (TSV)]

Guide to modENCODE expression level colors
 
 No/Extremely low expression (0 - 0)
 
 Very low expression (1 - 3)
 
 Low expression (4 - 10)
 
 Moderate expression (11 - 25)
 
 Moderately high expression (26 - 50)
 
 High expression (51 - 100)
 
 Very high expression (101 - 1000)
 
 Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 20
central nervous system, larvae L3
 
 2
central nervous system, pupae P8
 
 25
head, virgin 1-day female
 
 1
head, virgin 4-day female
 
 1
head, virgin 20-day female
 
 6
head, mated 1-day female
 
 2
head, mated 4-day female
 
 1
head, mated 20-day female
 
 6
head, mated 1-day male
 
 2
head, mated 4-day male
 
 1
head, mated 20-day male
 
 9
salivary gland, larvae L3 wandering
 
 3
salivary gland, white prepupae
 
 4
digestive system, larvae L3 wandering
 
 14
digestive system, 1-day adult
 
 24
digestive system, 4-day adult
 
 19
digestive system, 20-day adult
 
 11
fat body, larvae L3 wandering
 
 14
fat body, white prepupae
 
 10
fat body, pupae P8
 
 46
carcass, larvae L3 wandering
 
 3
carcass, 1-day adult
 
 72
carcass, 4-day adult
 
 46
carcass, 20-day adult
 
 30
ovary, virgin 4-day female
 
 10
ovary, mated 4-day female
 
 6
testis, mated 4-day male
 
 32
accessory gland, mated 4-day male
 
 6
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
Linear, scaled to Moderate expression
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 20
central nervous system, larvae L3
 
 2
central nervous system, pupae P8
 
 25
head, virgin 1-day female
 
 1
head, virgin 4-day female
 
 1
head, virgin 20-day female
 
 6
head, mated 1-day female
 
 2
head, mated 4-day female
 
 1
head, mated 20-day female
 
 6
head, mated 1-day male
 
 2
head, mated 4-day male
 
 1
head, mated 20-day male
 
 9
salivary gland, larvae L3 wandering
 
 3
salivary gland, white prepupae
 
 4
digestive system, larvae L3 wandering
 
 14
digestive system, 1-day adult
 
 24
digestive system, 4-day adult
 
 19
digestive system, 20-day adult
 
 11
fat body, larvae L3 wandering
 
 14
fat body, white prepupae
 
 10
fat body, pupae P8
 (46)
carcass, larvae L3 wandering
 
 3
carcass, 1-day adult
 (72)
carcass, 4-day adult
 (46)
carcass, 20-day adult
 (30)
ovary, virgin 4-day female
 
 10
ovary, mated 4-day female
 
 6
testis, mated 4-day male
 (32)
accessory gland, mated 4-day male
 
 6
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 20
central nervous system, larvae L3
 
 2
central nervous system, pupae P8
 
 25
head, virgin 1-day female
 
 1
head, virgin 4-day female
 
 1
head, virgin 20-day female
 
 6
head, mated 1-day female
 
 2
head, mated 4-day female
 
 1
head, mated 20-day female
 
 6
head, mated 1-day male
 
 2
head, mated 4-day male
 
 1
head, mated 20-day male
 
 9
salivary gland, larvae L3 wandering
 
 3
salivary gland, white prepupae
 
 4
digestive system, larvae L3 wandering
 
 14
digestive system, 1-day adult
 
 24
digestive system, 4-day adult
 
 19
digestive system, 20-day adult
 
 11
fat body, larvae L3 wandering
 
 14
fat body, white prepupae
 
 10
fat body, pupae P8
 
 46
carcass, larvae L3 wandering
 
 3
carcass, 1-day adult
 
 72
carcass, 4-day adult
 
 46
carcass, 20-day adult
 
 30
ovary, virgin 4-day female
 
 10
ovary, mated 4-day female
 
 6
testis, mated 4-day male
 
 32
accessory gland, mated 4-day male
 
 6
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 20
central nervous system, larvae L3
 
 2
central nervous system, pupae P8
 
 25
head, virgin 1-day female
 
 1
head, virgin 4-day female
 
 1
head, virgin 20-day female
 
 6
head, mated 1-day female
 
 2
head, mated 4-day female
 
 1
head, mated 20-day female
 
 6
head, mated 1-day male
 
 2
head, mated 4-day male
 
 1
head, mated 20-day male
 
 9
salivary gland, larvae L3 wandering
 
 3
salivary gland, white prepupae
 
 4
digestive system, larvae L3 wandering
 
 14
digestive system, 1-day adult
 
 24
digestive system, 4-day adult
 
 19
digestive system, 20-day adult
 
 11
fat body, larvae L3 wandering
 
 14
fat body, white prepupae
 
 10
fat body, pupae P8
 
 46
carcass, larvae L3 wandering
 
 3
carcass, 1-day adult
 
 72
carcass, 4-day adult
 
 46
carcass, 20-day adult
 
 30
ovary, virgin 4-day female
 
 10
ovary, mated 4-day female
 
 6
testis, mated 4-day male
 
 32
accessory gland, mated 4-day male
 
 6
Expression Level Scale
 Extremely high 
log, scaled to maximum expression level
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 20
central nervous system, larvae L3
 
 2
central nervous system, pupae P8
 
 25
head, virgin 1-day female
 
 1
head, virgin 4-day female
 
 1
head, virgin 20-day female
 
 6
head, mated 1-day female
 
 2
head, mated 4-day female
 
 1
head, mated 20-day female
 
 6
head, mated 1-day male
 
 2
head, mated 4-day male
 
 1
head, mated 20-day male
 
 9
salivary gland, larvae L3 wandering
 
 3
salivary gland, white prepupae
 
 4
digestive system, larvae L3 wandering
 
 14
digestive system, 1-day adult
 
 24
digestive system, 4-day adult
 
 19
digestive system, 20-day adult
 
 11
fat body, larvae L3 wandering
 
 14
fat body, white prepupae
 
 10
fat body, pupae P8
 
 46
carcass, larvae L3 wandering
 
 3
carcass, 1-day adult
 
 72
carcass, 4-day adult
 
 46
carcass, 20-day adult
 
 30
ovary, virgin 4-day female
 
 10
ovary, mated 4-day female
 
 6
testis, mated 4-day male
 
 32
accessory gland, mated 4-day male
 
 6
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Moderate expression
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 20
central nervous system, larvae L3
 
 2
central nervous system, pupae P8
 
 25
head, virgin 1-day female
 
 1
head, virgin 4-day female
 
 1
head, virgin 20-day female
 
 6
head, mated 1-day female
 
 2
head, mated 4-day female
 
 1
head, mated 20-day female
 
 6
head, mated 1-day male
 
 2
head, mated 4-day male
 
 1
head, mated 20-day male
 
 9
salivary gland, larvae L3 wandering
 
 3
salivary gland, white prepupae
 
 4
digestive system, larvae L3 wandering
 
 14
digestive system, 1-day adult
 
 24
digestive system, 4-day adult
 
 19
digestive system, 20-day adult
 
 11
fat body, larvae L3 wandering
 
 14
fat body, white prepupae
 
 10
fat body, pupae P8
 (46)
carcass, larvae L3 wandering
 
 3
carcass, 1-day adult
 (72)
carcass, 4-day adult
 (46)
carcass, 20-day adult
 30
ovary, virgin 4-day female
 
 10
ovary, mated 4-day female
 
 6
testis, mated 4-day male
 32
accessory gland, mated 4-day male
 
 6
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 20
central nervous system, larvae L3
 
 2
central nervous system, pupae P8
 
 25
head, virgin 1-day female
 
 1
head, virgin 4-day female
 
 1
head, virgin 20-day female
 
 6
head, mated 1-day female
 
 2
head, mated 4-day female
 
 1
head, mated 20-day female
 
 6
head, mated 1-day male
 
 2
head, mated 4-day male
 
 1
head, mated 20-day male
 
 9
salivary gland, larvae L3 wandering
 
 3
salivary gland, white prepupae
 
 4
digestive system, larvae L3 wandering
 
 14
digestive system, 1-day adult
 
 24
digestive system, 4-day adult
 
 19
digestive system, 20-day adult
 
 11
fat body, larvae L3 wandering
 
 14
fat body, white prepupae
 
 10
fat body, pupae P8
 
 46
carcass, larvae L3 wandering
 
 3
carcass, 1-day adult
 
 72
carcass, 4-day adult
 
 46
carcass, 20-day adult
 
 30
ovary, virgin 4-day female
 
 10
ovary, mated 4-day female
 
 6
testis, mated 4-day male
 
 32
accessory gland, mated 4-day male
 
 6
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 20
central nervous system, larvae L3
 
 2
central nervous system, pupae P8
 
 25
head, virgin 1-day female
 
 1
head, virgin 4-day female
 
 1
head, virgin 20-day female
 
 6
head, mated 1-day female
 
 2
head, mated 4-day female
 
 1
head, mated 20-day female
 
 6
head, mated 1-day male
 
 2
head, mated 4-day male
 
 1
head, mated 20-day male
 
 9
salivary gland, larvae L3 wandering
 
 3
salivary gland, white prepupae
 
 4
digestive system, larvae L3 wandering
 
 14
digestive system, 1-day adult
 
 24
digestive system, 4-day adult
 
 19
digestive system, 20-day adult
 
 11
fat body, larvae L3 wandering
 
 14
fat body, white prepupae
 
 10
fat body, pupae P8
 
 46
carcass, larvae L3 wandering
 
 3
carcass, 1-day adult
 
 72
carcass, 4-day adult
 
 46
carcass, 20-day adult
 
 30
ovary, virgin 4-day female
 
 10
ovary, mated 4-day female
 
 6
testis, mated 4-day male
 
 32
accessory gland, mated 4-day male
 
 6
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 
central nervous system, larvae L3
 
 
central nervous system, pupae P8
 
 
head, virgin 1-day female
 
 
head, virgin 4-day female
 
 
head, virgin 20-day female
 
 
head, mated 1-day female
 
 
head, mated 4-day female
 
 
head, mated 20-day female
 
 
head, mated 1-day male
 
 
head, mated 4-day male
 
 
head, mated 20-day male
 
 
salivary gland, larvae L3 wandering
 
 
salivary gland, white prepupae
 
 
digestive system, larvae L3 wandering
 
 
digestive system, 1-day adult
 
 
digestive system, 4-day adult
 
 
digestive system, 20-day adult
 
 
fat body, larvae L3 wandering
 
 
fat body, white prepupae
 
 
fat body, pupae P8
 
 
carcass, larvae L3 wandering
 
 
carcass, 1-day adult
 
 
carcass, 4-day adult
 
 
carcass, 20-day adult
 
 
ovary, virgin 4-day female
 
 
ovary, mated 4-day female
 
 
testis, mated 4-day male
 
 
accessory gland, mated 4-day male
 
 

hide modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)


   Styles
   Scales

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed during late pupal stages. This gene is annotated by FlyBase as a dicistronic gene, meaning that some or all of its transcripts encode two or more polypeptide-coding open reading frames (ORFs) , with each ORF assigned to a different gene. The distribution of RNA-Seq coverage data amongst the different encoded genes cannot be determined.
[download data (TSV)]

Guide to modENCODE expression level colors
 
 No/Extremely low expression (0 - 0)
 
 Very low expression (1 - 3)
 
 Low expression (4 - 10)
 
 Moderate expression (11 - 25)
 
 Moderately high expression (26 - 50)
 
 High expression (51 - 100)
 
 Very high expression (101 - 1000)
 
 Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 16
embryo 02-04hr
 
 12
embryo 04-06hr
 
 5
embryo 06-08hr
 
 5
embryo 08-10hr
 
 10
embryo 10-12hr
 
 16
embryo 12-14hr
 
 9
embryo 14-16hr
 
 7
embryo 16-18hr
 
 5
embryo 18-20hr
 
 7
embryo 20-22hr
 
 10
embryo 22-24hr
 
 8
larva L1
 
 4
larva L2
 
 5
larva L3 12hr old
 
 6
larva L3 puffstage 1-2
 
 3
larva L3 puffstage 3-6
 
 4
larva L3 puffstage 7-9
 
 8
white prepupae new
 
 13
white prepupae 12hr
 
 71
white prepupae 24hr
 
 57
pupae 2d postWPP
 
 203
pupae 3d postWPP
 
 27
pupae 4d postWPP
 
 116
adult male 01day
 
 17
adult male 05day
 
 19
adult male 30day
 
 27
adult female 01day
 
 6
adult female 05day
 
 7
adult female 30day
 
 8
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 16
embryo 02-04hr
 
 12
embryo 04-06hr
 
 5
embryo 06-08hr
 
 5
embryo 08-10hr
 
 10
embryo 10-12hr
 
 16
embryo 12-14hr
 
 9
embryo 14-16hr
 
 7
embryo 16-18hr
 
 5
embryo 18-20hr
 
 7
embryo 20-22hr
 
 10
embryo 22-24hr
 
 8
larva L1
 
 4
larva L2
 
 5
larva L3 12hr old
 
 6
larva L3 puffstage 1-2
 
 3
larva L3 puffstage 3-6
 
 4
larva L3 puffstage 7-9
 
 8
white prepupae new
 
 13
white prepupae 12hr
 (71)
white prepupae 24hr
 (57)
pupae 2d postWPP
 (203)
pupae 3d postWPP
 (27)
pupae 4d postWPP
 (116)
adult male 01day
 
 17
adult male 05day
 
 19
adult male 30day
 (27)
adult female 01day
 
 6
adult female 05day
 
 7
adult female 30day
 
 8
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 16
embryo 02-04hr
 
 12
embryo 04-06hr
 
 5
embryo 06-08hr
 
 5
embryo 08-10hr
 
 10
embryo 10-12hr
 
 16
embryo 12-14hr
 
 9
embryo 14-16hr
 
 7
embryo 16-18hr
 
 5
embryo 18-20hr
 
 7
embryo 20-22hr
 
 10
embryo 22-24hr
 
 8
larva L1
 
 4
larva L2
 
 5
larva L3 12hr old
 
 6
larva L3 puffstage 1-2
 
 3
larva L3 puffstage 3-6
 
 4
larva L3 puffstage 7-9
 
 8
white prepupae new
 
 13
white prepupae 12hr
 
 71
white prepupae 24hr
 
 57
pupae 2d postWPP
 (203)
pupae 3d postWPP
 
 27
pupae 4d postWPP
 (116)
adult male 01day
 
 17
adult male 05day
 
 19
adult male 30day
 
 27
adult female 01day
 
 6
adult female 05day
 
 7
adult female 30day
 
 8
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 16
embryo 02-04hr
 
 12
embryo 04-06hr
 
 5
embryo 06-08hr
 
 5
embryo 08-10hr
 
 10
embryo 10-12hr
 
 16
embryo 12-14hr
 
 9
embryo 14-16hr
 
 7
embryo 16-18hr
 
 5
embryo 18-20hr
 
 7
embryo 20-22hr
 
 10
embryo 22-24hr
 
 8
larva L1
 
 4
larva L2
 
 5
larva L3 12hr old
 
 6
larva L3 puffstage 1-2
 
 3
larva L3 puffstage 3-6
 
 4
larva L3 puffstage 7-9
 
 8
white prepupae new
 
 13
white prepupae 12hr
 
 71
white prepupae 24hr
 
 57
pupae 2d postWPP
 
 203
pupae 3d postWPP
 
 27
pupae 4d postWPP
 
 116
adult male 01day
 
 17
adult male 05day
 
 19
adult male 30day
 
 27
adult female 01day
 
 6
adult female 05day
 
 7
adult female 30day
 
 8
Expression Level Scale
 Extremely high 
log, scaled to maximum expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 16
embryo 02-04hr
 
 12
embryo 04-06hr
 
 5
embryo 06-08hr
 
 5
embryo 08-10hr
 
 10
embryo 10-12hr
 
 16
embryo 12-14hr
 
 9
embryo 14-16hr
 
 7
embryo 16-18hr
 
 5
embryo 18-20hr
 
 7
embryo 20-22hr
 
 10
embryo 22-24hr
 
 8
larva L1
 
 4
larva L2
 
 5
larva L3 12hr old
 
 6
larva L3 puffstage 1-2
 
 3
larva L3 puffstage 3-6
 
 4
larva L3 puffstage 7-9
 
 8
white prepupae new
 
 13
white prepupae 12hr
 
 71
white prepupae 24hr
 
 57
pupae 2d postWPP
 
 203
pupae 3d postWPP
 
 27
pupae 4d postWPP
 
 116
adult male 01day
 
 17
adult male 05day
 
 19
adult male 30day
 
 27
adult female 01day
 
 6
adult female 05day
 
 7
adult female 30day
 
 8
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 16
embryo 02-04hr
 
 12
embryo 04-06hr
 
 5
embryo 06-08hr
 
 5
embryo 08-10hr
 
 10
embryo 10-12hr
 
 16
embryo 12-14hr
 
 9
embryo 14-16hr
 
 7
embryo 16-18hr
 
 5
embryo 18-20hr
 
 7
embryo 20-22hr
 
 10
embryo 22-24hr
 
 8
larva L1
 
 4
larva L2
 
 5
larva L3 12hr old
 
 6
larva L3 puffstage 1-2
 
 3
larva L3 puffstage 3-6
 
 4
larva L3 puffstage 7-9
 
 8
white prepupae new
 
 13
white prepupae 12hr
 (71)
white prepupae 24hr
 (57)
pupae 2d postWPP
 (203)
pupae 3d postWPP
 27
pupae 4d postWPP
 (116)
adult male 01day
 
 17
adult male 05day
 
 19
adult male 30day
 27
adult female 01day
 
 6
adult female 05day
 
 7
adult female 30day
 
 8
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 16
embryo 02-04hr
 
 12
embryo 04-06hr
 
 5
embryo 06-08hr
 
 5
embryo 08-10hr
 
 10
embryo 10-12hr
 
 16
embryo 12-14hr
 
 9
embryo 14-16hr
 
 7
embryo 16-18hr
 
 5
embryo 18-20hr
 
 7
embryo 20-22hr
 
 10
embryo 22-24hr
 
 8
larva L1
 
 4
larva L2
 
 5
larva L3 12hr old
 
 6
larva L3 puffstage 1-2
 
 3
larva L3 puffstage 3-6
 
 4
larva L3 puffstage 7-9
 
 8
white prepupae new
 
 13
white prepupae 12hr
 
 71
white prepupae 24hr
 
 57
pupae 2d postWPP
 (203)
pupae 3d postWPP
 
 27
pupae 4d postWPP
 116
adult male 01day
 
 17
adult male 05day
 
 19
adult male 30day
 
 27
adult female 01day
 
 6
adult female 05day
 
 7
adult female 30day
 
 8
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 16
embryo 02-04hr
 
 12
embryo 04-06hr
 
 5
embryo 06-08hr
 
 5
embryo 08-10hr
 
 10
embryo 10-12hr
 
 16
embryo 12-14hr
 
 9
embryo 14-16hr
 
 7
embryo 16-18hr
 
 5
embryo 18-20hr
 
 7
embryo 20-22hr
 
 10
embryo 22-24hr
 
 8
larva L1
 
 4
larva L2
 
 5
larva L3 12hr old
 
 6
larva L3 puffstage 1-2
 
 3
larva L3 puffstage 3-6
 
 4
larva L3 puffstage 7-9
 
 8
white prepupae new
 
 13
white prepupae 12hr
 
 71
white prepupae 24hr
 
 57
pupae 2d postWPP
 
 203
pupae 3d postWPP
 
 27
pupae 4d postWPP
 
 116
adult male 01day
 
 17
adult male 05day
 
 19
adult male 30day
 
 27
adult female 01day
 
 6
adult female 05day
 
 7
adult female 30day
 
 8
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Developmental Stage   Expression Level
embryo 00-02hr
 
 
embryo 02-04hr
 
 
embryo 04-06hr
 
 
embryo 06-08hr
 
 
embryo 08-10hr
 
 
embryo 10-12hr
 
 
embryo 12-14hr
 
 
embryo 14-16hr
 
 
embryo 16-18hr
 
 
embryo 18-20hr
 
 
embryo 20-22hr
 
 
embryo 22-24hr
 
 
larva L1
 
 
larva L2
 
 
larva L3 12hr old
 
 
larva L3 puffstage 1-2
 
 
larva L3 puffstage 3-6
 
 
larva L3 puffstage 7-9
 
 
white prepupae new
 
 
white prepupae 12hr
 
 
white prepupae 24hr
 
 
pupae 2d postWPP
 
 
pupae 3d postWPP
 
 
pupae 4d postWPP
 
 
adult male 01day
 
 
adult male 05day
 
 
adult male 30day
 
 
adult female 01day
 
 
adult female 05day
 
 
adult female 30day
 
 

modENCODE Temporal Expression Data (Graveley et al., 2011)
hide modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)


   Styles
   Scales


[download data (TSV)]

Guide to modENCODE expression level colors
 
 No/Extremely low expression (0 - 0)
 
 Very low expression (1 - 3)
 
 Low expression (4 - 10)
 
 Moderate expression (11 - 25)
 
 Moderately high expression (26 - 50)
 
 High expression (51 - 100)
 
 Very high expression (101 - 1000)
 
 Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line   Expression Level
Schneider line 2 S2R+
 
 7
Schneider line 2 Sg4
 
 43
embryonic 1182-4H
 
 3
embryonic GM2
 
 62
embryonic Kc167
 
 96
embryonic S1
 
 246
embryonic S3
 
 50
leg disc CME L1
 
 48
wing disc CME-W2
 
 42
wing disc ML-DmD8
 
 10
wing disc ML-DmD9
 
 23
wing disc ML-DmD16-c3
 
 12
wing disc ML-DmD21
 
 14
wing disc ML-DmD32
 
 11
haltere disc ML-DmD17-c3
 
 9
eye-antennal disc ML-DmD11
 
 5
antennal disc ML-DmD20-c5
 
 9
mixed discs ML-DmD4-c1
 
 75
CNS ML-DmBG1-c1
 
 31
CNS ML-DmBG2-c2
 
 151
tumorous blood cells mbn2
 
 96
ovary fGS/OSS
 
 83
ovary OSC
 
 28
ovary OSS
 
 10
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Moderate expression
Cell Line   Expression Level
Schneider line 2 S2R+
 
 7
Schneider line 2 Sg4
 (43)
embryonic 1182-4H
 
 3
embryonic GM2
 (62)
embryonic Kc167
 (96)
embryonic S1
 (246)
embryonic S3
 (50)
leg disc CME L1
 (48)
wing disc CME-W2
 (42)
wing disc ML-DmD8
 
 10
wing disc ML-DmD9
 
 23
wing disc ML-DmD16-c3
 
 12
wing disc ML-DmD21
 
 14
wing disc ML-DmD32
 
 11
haltere disc ML-DmD17-c3
 
 9
eye-antennal disc ML-DmD11
 
 5
antennal disc ML-DmD20-c5
 
 9
mixed discs ML-DmD4-c1
 (75)
CNS ML-DmBG1-c1
 (31)
CNS ML-DmBG2-c2
 (151)
tumorous blood cells mbn2
 (96)
ovary fGS/OSS
 (83)
ovary OSC
 (28)
ovary OSS
 
 10
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Cell Line   Expression Level
Schneider line 2 S2R+
 
 7
Schneider line 2 Sg4
 
 43
embryonic 1182-4H
 
 3
embryonic GM2
 
 62
embryonic Kc167
 
 96
embryonic S1
 (246)
embryonic S3
 
 50
leg disc CME L1
 
 48
wing disc CME-W2
 
 42
wing disc ML-DmD8
 
 10
wing disc ML-DmD9
 
 23
wing disc ML-DmD16-c3
 
 12
wing disc ML-DmD21
 
 14
wing disc ML-DmD32
 
 11
haltere disc ML-DmD17-c3
 
 9
eye-antennal disc ML-DmD11
 
 5
antennal disc ML-DmD20-c5
 
 9
mixed discs ML-DmD4-c1
 
 75
CNS ML-DmBG1-c1
 
 31
CNS ML-DmBG2-c2
 (151)
tumorous blood cells mbn2
 
 96
ovary fGS/OSS
 
 83
ovary OSC
 
 28
ovary OSS
 
 10
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Cell Line   Expression Level
Schneider line 2 S2R+
 
 7
Schneider line 2 Sg4
 
 43
embryonic 1182-4H
 
 3
embryonic GM2
 
 62
embryonic Kc167
 
 96
embryonic S1
 
 246
embryonic S3
 
 50
leg disc CME L1
 
 48
wing disc CME-W2
 
 42
wing disc ML-DmD8
 
 10
wing disc ML-DmD9
 
 23
wing disc ML-DmD16-c3
 
 12
wing disc ML-DmD21
 
 14
wing disc ML-DmD32
 
 11
haltere disc ML-DmD17-c3
 
 9
eye-antennal disc ML-DmD11
 
 5
antennal disc ML-DmD20-c5
 
 9
mixed discs ML-DmD4-c1
 
 75
CNS ML-DmBG1-c1
 
 31
CNS ML-DmBG2-c2
 
 151
tumorous blood cells mbn2
 
 96
ovary fGS/OSS
 
 83
ovary OSC
 
 28
ovary OSS
 
 10
Expression Level Scale
 Extremely high 
log, scaled to maximum expression level
Cell Line   Expression Level
Schneider line 2 S2R+
 
 7
Schneider line 2 Sg4
 
 43
embryonic 1182-4H
 
 3
embryonic GM2
 
 62
embryonic Kc167
 
 96
embryonic S1
 
 246
embryonic S3
 
 50
leg disc CME L1
 
 48
wing disc CME-W2
 
 42
wing disc ML-DmD8
 
 10
wing disc ML-DmD9
 
 23
wing disc ML-DmD16-c3
 
 12
wing disc ML-DmD21
 
 14
wing disc ML-DmD32
 
 11
haltere disc ML-DmD17-c3
 
 9
eye-antennal disc ML-DmD11
 
 5
antennal disc ML-DmD20-c5
 
 9
mixed discs ML-DmD4-c1
 
 75
CNS ML-DmBG1-c1
 
 31
CNS ML-DmBG2-c2
 
 151
tumorous blood cells mbn2
 
 96
ovary fGS/OSS
 
 83
ovary OSC
 
 28
ovary OSS
 
 10
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Moderate expression
Cell Line   Expression Level
Schneider line 2 S2R+
 
 7
Schneider line 2 Sg4
 (43)
embryonic 1182-4H
 
 3
embryonic GM2
 (62)
embryonic Kc167
 (96)
embryonic S1
 (246)
embryonic S3
 (50)
leg disc CME L1
 (48)
wing disc CME-W2
 (42)
wing disc ML-DmD8
 
 10
wing disc ML-DmD9
 
 23
wing disc ML-DmD16-c3
 
 12
wing disc ML-DmD21
 
 14
wing disc ML-DmD32
 
 11
haltere disc ML-DmD17-c3
 
 9
eye-antennal disc ML-DmD11
 
 5
antennal disc ML-DmD20-c5
 
 9
mixed discs ML-DmD4-c1
 (75)
CNS ML-DmBG1-c1
 31
CNS ML-DmBG2-c2
 (151)
tumorous blood cells mbn2
 (96)
ovary fGS/OSS
 (83)
ovary OSC
 28
ovary OSS
 
 10
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Cell Line   Expression Level
Schneider line 2 S2R+
 
 7
Schneider line 2 Sg4
 
 43
embryonic 1182-4H
 
 3
embryonic GM2
 
 62
embryonic Kc167
 
 96
embryonic S1
 (246)
embryonic S3
 
 50
leg disc CME L1
 
 48
wing disc CME-W2
 
 42
wing disc ML-DmD8
 
 10
wing disc ML-DmD9
 
 23
wing disc ML-DmD16-c3
 
 12
wing disc ML-DmD21
 
 14
wing disc ML-DmD32
 
 11
haltere disc ML-DmD17-c3
 
 9
eye-antennal disc ML-DmD11
 
 5
antennal disc ML-DmD20-c5
 
 9
mixed discs ML-DmD4-c1
 
 75
CNS ML-DmBG1-c1
 
 31
CNS ML-DmBG2-c2
 (151)
tumorous blood cells mbn2
 
 96
ovary fGS/OSS
 
 83
ovary OSC
 
 28
ovary OSS
 
 10
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Cell Line   Expression Level
Schneider line 2 S2R+
 
 7
Schneider line 2 Sg4
 
 43
embryonic 1182-4H
 
 3
embryonic GM2
 
 62
embryonic Kc167
 
 96
embryonic S1
 
 246
embryonic S3
 
 50
leg disc CME L1
 
 48
wing disc CME-W2
 
 42
wing disc ML-DmD8
 
 10
wing disc ML-DmD9
 
 23
wing disc ML-DmD16-c3
 
 12
wing disc ML-DmD21
 
 14
wing disc ML-DmD32
 
 11
haltere disc ML-DmD17-c3
 
 9
eye-antennal disc ML-DmD11
 
 5
antennal disc ML-DmD20-c5
 
 9
mixed discs ML-DmD4-c1
 
 75
CNS ML-DmBG1-c1
 
 31
CNS ML-DmBG2-c2
 
 151
tumorous blood cells mbn2
 
 96
ovary fGS/OSS
 
 83
ovary OSC
 
 28
ovary OSS
 
 10
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Cell Line   Expression Level
Schneider line 2 S2R+
 
 
Schneider line 2 Sg4
 
 
embryonic 1182-4H
 
 
embryonic GM2
 
 
embryonic Kc167
 
 
embryonic S1
 
 
embryonic S3
 
 
leg disc CME L1
 
 
wing disc CME-W2
 
 
wing disc ML-DmD8
 
 
wing disc ML-DmD9
 
 
wing disc ML-DmD16-c3
 
 
wing disc ML-DmD21
 
 
wing disc ML-DmD32
 
 
haltere disc ML-DmD17-c3
 
 
eye-antennal disc ML-DmD11
 
 
antennal disc ML-DmD20-c5
 
 
mixed discs ML-DmD4-c1
 
 
CNS ML-DmBG1-c1
 
 
CNS ML-DmBG2-c2
 
 
tumorous blood cells mbn2
 
 
ovary fGS/OSS
 
 
ovary OSC
 
 
ovary OSS
 
 

hide modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)


   Styles
   Scales


[download data (TSV)]

Guide to modENCODE expression level colors
 
 No/Extremely low expression (0 - 0)
 
 Very low expression (1 - 3)
 
 Low expression (4 - 10)
 
 Moderate expression (11 - 25)
 
 Moderately high expression (26 - 50)
 
 High expression (51 - 100)
 
 Very high expression (101 - 1000)
 
 Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment   Expression Level
extended cold, 4-day adult
 
 33
cold shock, 4-day adult
 
 11
heat shock, 4-day adult
 
 541
Cadmium 50 mM 6 hrs, larvae L3
 
 9
Cadmium 50 mM 12 hrs, larvae L3
 
 20
Cadmium 50 mM 48 hrs, 4-day adult
 
 43
Cadmium 100 mM 48 hrs, 4-day adult
 
 175
Copper 0.5 mM 12 hrs, larvae L3
 
 36
Copper 15 mM 48 hrs, 4-day adult
 
 62
Zinc 5 mM 12 hrs, larvae L3
 
 19
Zinc 4.5 mM 48 hrs, 4-day adult
 
 25
Ethanol 2.5% 3 hrs, larvae L3
 
 484
Ethanol 5% 3 hrs, larvae L3
 
 17
Ethanol 10% 3 hrs, larvae L3
 
 14
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 15
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 21
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 19
Paraquat 5 mM 48 hrs, 4-day adult
 
 10
Paraquat 10 mM 48 hrs, 4-day adult
 
 149
Rotenone 2 μg 12 hrs, larvae L3
 
 11
Rotenone 8 μg 12 hrs, larvae L3
 
 39
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Moderate expression
Treatment   Expression Level
extended cold, 4-day adult
 (33)
cold shock, 4-day adult
 
 11
heat shock, 4-day adult
 (541)
Cadmium 50 mM 6 hrs, larvae L3
 
 9
Cadmium 50 mM 12 hrs, larvae L3
 
 20
Cadmium 50 mM 48 hrs, 4-day adult
 (43)
Cadmium 100 mM 48 hrs, 4-day adult
 (175)
Copper 0.5 mM 12 hrs, larvae L3
 (36)
Copper 15 mM 48 hrs, 4-day adult
 (62)
Zinc 5 mM 12 hrs, larvae L3
 
 19
Zinc 4.5 mM 48 hrs, 4-day adult
 
 25
Ethanol 2.5% 3 hrs, larvae L3
 (484)
Ethanol 5% 3 hrs, larvae L3
 
 17
Ethanol 10% 3 hrs, larvae L3
 
 14
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 15
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 21
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 19
Paraquat 5 mM 48 hrs, 4-day adult
 
 10
Paraquat 10 mM 48 hrs, 4-day adult
 (149)
Rotenone 2 μg 12 hrs, larvae L3
 
 11
Rotenone 8 μg 12 hrs, larvae L3
 (39)
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Treatment   Expression Level
extended cold, 4-day adult
 
 33
cold shock, 4-day adult
 
 11
heat shock, 4-day adult
 (541)
Cadmium 50 mM 6 hrs, larvae L3
 
 9
Cadmium 50 mM 12 hrs, larvae L3
 
 20
Cadmium 50 mM 48 hrs, 4-day adult
 
 43
Cadmium 100 mM 48 hrs, 4-day adult
 (175)
Copper 0.5 mM 12 hrs, larvae L3
 
 36
Copper 15 mM 48 hrs, 4-day adult
 
 62
Zinc 5 mM 12 hrs, larvae L3
 
 19
Zinc 4.5 mM 48 hrs, 4-day adult
 
 25
Ethanol 2.5% 3 hrs, larvae L3
 (484)
Ethanol 5% 3 hrs, larvae L3
 
 17
Ethanol 10% 3 hrs, larvae L3
 
 14
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 15
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 21
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 19
Paraquat 5 mM 48 hrs, 4-day adult
 
 10
Paraquat 10 mM 48 hrs, 4-day adult
 (149)
Rotenone 2 μg 12 hrs, larvae L3
 
 11
Rotenone 8 μg 12 hrs, larvae L3
 
 39
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Treatment   Expression Level
extended cold, 4-day adult
 
 33
cold shock, 4-day adult
 
 11
heat shock, 4-day adult
 
 541
Cadmium 50 mM 6 hrs, larvae L3
 
 9
Cadmium 50 mM 12 hrs, larvae L3
 
 20
Cadmium 50 mM 48 hrs, 4-day adult
 
 43
Cadmium 100 mM 48 hrs, 4-day adult
 
 175
Copper 0.5 mM 12 hrs, larvae L3
 
 36
Copper 15 mM 48 hrs, 4-day adult
 
 62
Zinc 5 mM 12 hrs, larvae L3
 
 19
Zinc 4.5 mM 48 hrs, 4-day adult
 
 25
Ethanol 2.5% 3 hrs, larvae L3
 
 484
Ethanol 5% 3 hrs, larvae L3
 
 17
Ethanol 10% 3 hrs, larvae L3
 
 14
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 15
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 21
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 19
Paraquat 5 mM 48 hrs, 4-day adult
 
 10
Paraquat 10 mM 48 hrs, 4-day adult
 
 149
Rotenone 2 μg 12 hrs, larvae L3
 
 11
Rotenone 8 μg 12 hrs, larvae L3
 
 39
Expression Level Scale
 Extremely high 
log, scaled to maximum expression level
Treatment   Expression Level
extended cold, 4-day adult
 
 33
cold shock, 4-day adult
 
 11
heat shock, 4-day adult
 
 541
Cadmium 50 mM 6 hrs, larvae L3
 
 9
Cadmium 50 mM 12 hrs, larvae L3
 
 20
Cadmium 50 mM 48 hrs, 4-day adult
 
 43
Cadmium 100 mM 48 hrs, 4-day adult
 
 175
Copper 0.5 mM 12 hrs, larvae L3
 
 36
Copper 15 mM 48 hrs, 4-day adult
 
 62
Zinc 5 mM 12 hrs, larvae L3
 
 19
Zinc 4.5 mM 48 hrs, 4-day adult
 
 25
Ethanol 2.5% 3 hrs, larvae L3
 
 484
Ethanol 5% 3 hrs, larvae L3
 
 17
Ethanol 10% 3 hrs, larvae L3
 
 14
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 15
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 21
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 19
Paraquat 5 mM 48 hrs, 4-day adult
 
 10
Paraquat 10 mM 48 hrs, 4-day adult
 
 149
Rotenone 2 μg 12 hrs, larvae L3
 
 11
Rotenone 8 μg 12 hrs, larvae L3
 
 39
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
log, scaled to Moderate expression
Treatment   Expression Level
extended cold, 4-day adult
 (33)
cold shock, 4-day adult
 
 11
heat shock, 4-day adult
 (541)
Cadmium 50 mM 6 hrs, larvae L3
 
 9
Cadmium 50 mM 12 hrs, larvae L3
 
 20
Cadmium 50 mM 48 hrs, 4-day adult
 (43)
Cadmium 100 mM 48 hrs, 4-day adult
 (175)
Copper 0.5 mM 12 hrs, larvae L3
 (36)
Copper 15 mM 48 hrs, 4-day adult
 (62)
Zinc 5 mM 12 hrs, larvae L3
 
 19
Zinc 4.5 mM 48 hrs, 4-day adult
 
 25
Ethanol 2.5% 3 hrs, larvae L3
 (484)
Ethanol 5% 3 hrs, larvae L3
 
 17
Ethanol 10% 3 hrs, larvae L3
 
 14
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 15
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 21
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 19
Paraquat 5 mM 48 hrs, 4-day adult
 
 10
Paraquat 10 mM 48 hrs, 4-day adult
 (149)
Rotenone 2 μg 12 hrs, larvae L3
 
 11
Rotenone 8 μg 12 hrs, larvae L3
 (39)
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Treatment   Expression Level
extended cold, 4-day adult
 
 33
cold shock, 4-day adult
 
 11
heat shock, 4-day adult
 (541)
Cadmium 50 mM 6 hrs, larvae L3
 
 9
Cadmium 50 mM 12 hrs, larvae L3
 
 20
Cadmium 50 mM 48 hrs, 4-day adult
 
 43
Cadmium 100 mM 48 hrs, 4-day adult
 (175)
Copper 0.5 mM 12 hrs, larvae L3
 
 36
Copper 15 mM 48 hrs, 4-day adult
 
 62
Zinc 5 mM 12 hrs, larvae L3
 
 19
Zinc 4.5 mM 48 hrs, 4-day adult
 
 25
Ethanol 2.5% 3 hrs, larvae L3
 (484)
Ethanol 5% 3 hrs, larvae L3
 
 17
Ethanol 10% 3 hrs, larvae L3
 
 14
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 15
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 21
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 19
Paraquat 5 mM 48 hrs, 4-day adult
 
 10
Paraquat 10 mM 48 hrs, 4-day adult
 (149)
Rotenone 2 μg 12 hrs, larvae L3
 
 11
Rotenone 8 μg 12 hrs, larvae L3
 
 39
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Treatment   Expression Level
extended cold, 4-day adult
 
 33
cold shock, 4-day adult
 
 11
heat shock, 4-day adult
 
 541
Cadmium 50 mM 6 hrs, larvae L3
 
 9
Cadmium 50 mM 12 hrs, larvae L3
 
 20
Cadmium 50 mM 48 hrs, 4-day adult
 
 43
Cadmium 100 mM 48 hrs, 4-day adult
 
 175
Copper 0.5 mM 12 hrs, larvae L3
 
 36
Copper 15 mM 48 hrs, 4-day adult
 
 62
Zinc 5 mM 12 hrs, larvae L3
 
 19
Zinc 4.5 mM 48 hrs, 4-day adult
 
 25
Ethanol 2.5% 3 hrs, larvae L3
 
 484
Ethanol 5% 3 hrs, larvae L3
 
 17
Ethanol 10% 3 hrs, larvae L3
 
 14
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 15
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 21
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 19
Paraquat 5 mM 48 hrs, 4-day adult
 
 10
Paraquat 10 mM 48 hrs, 4-day adult
 
 149
Rotenone 2 μg 12 hrs, larvae L3
 
 11
Rotenone 8 μg 12 hrs, larvae L3
 
 39
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Treatment   Expression Level
extended cold, 4-day adult
 
 
cold shock, 4-day adult
 
 
heat shock, 4-day adult
 
 
Cadmium 50 mM 6 hrs, larvae L3
 
 
Cadmium 50 mM 12 hrs, larvae L3
 
 
Cadmium 50 mM 48 hrs, 4-day adult
 
 
Cadmium 100 mM 48 hrs, 4-day adult
 
 
Copper 0.5 mM 12 hrs, larvae L3
 
 
Copper 15 mM 48 hrs, 4-day adult
 
 
Zinc 5 mM 12 hrs, larvae L3
 
 
Zinc 4.5 mM 48 hrs, 4-day adult
 
 
Ethanol 2.5% 3 hrs, larvae L3
 
 
Ethanol 5% 3 hrs, larvae L3
 
 
Ethanol 10% 3 hrs, larvae L3
 
 
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 
Paraquat 5 mM 48 hrs, 4-day adult
 
 
Paraquat 10 mM 48 hrs, 4-day adult
 
 
Rotenone 2 μg 12 hrs, larvae L3
 
 
Rotenone 8 μg 12 hrs, larvae L3
 
 

hide Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
(The modENCODE Consortium, 2010)
hide External Data & Images
Linkouts
BDGP expression data
•
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
•
hide Alleles & Phenotypes
hide Summary of Allele Phenotypes
Lethality
Allele
viable
Sterility
Allele
fertile
Other Phenotypes
Allele
cold stress response defective, with Scer\GAL4Act5C.PI
heat stress response defective | tetracycline conditional, with Tn10\tetRAct5C.T:Hsim\VP16
locomotor behavior defective
long lived, with Scer\GAL4Act5C.PI
oxidative stress response defective | tetracycline conditional, with Tn10\tetRAct5C.T:Hsim\VP16
short lived
short lived | :heat sensitive | tetracycline conditional, with Tn10\tetRAct5C.T:Hsim\VP16
Phenotype manifest in
Allele
hide Classical Alleles ( 11 )
For All Classical Alleles Show

Allele of Hsp22ClassMutagenStocksKnown lesion
Hsp22BG02409
1 Yes
Hsp22c06661
1 --
Hsp22d00797
1 --
Hsp22d07618
1 --
Hsp22EY099091 Yes
Hsp22MI06285
1 --
Hsp22NP2055
1 --
Hsp22NP5403
1 --
Hsp22d07456
0 --
Hsp22EP32470 Yes
Hsp22EP3583-11
0 Yes
hide Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show

Allele of Hsp22ClassMutagenStocksKnown lesion
Hsp22GD8704
1 --
Hsp22T6BV10 Yes
Hsp22Tn10\tetO.cBa0 Yes
hide Aneuploid Aberrations
Disrupted in
(Sudi et al., 2008)
(Sudi et al., 2008)
(Sudi et al., 2008)
hide Transgenic Constructs & Insertions
Transgenic Constructs
Type of construct
Name
Expression data
reporter construct
P{Hsp22-lacZ.5'Δ-114}
No
P{Hsp22-lacZ.5'Δ-314.mut}
No
P{Hsp22-lacZ.5'Δ-314}
No
UAS construct
P{tetO-Hsp22.B}
NA
heat-shock construct
P{GD8704}
NA
P{tetO-Hsp22.B}
NA
characterization construct
P{Hsp22-DsRed.322}
NA
Insertions
Type of insertions
Name
Expression data
insertion of mobile activating element
P{EP}EP3583-10
NA
P{EP}EP3583-12
NA
P{EP}EP3583-18
NA
P{EP}Hsp22EP3583-11
NA
P{EP}Hsp67BbEP3247
NA
P{EPgy2}Hsp22EY09909
NA
P{XP}Hsp22d00797
NA
P{XP}Hsp22d07456
NA
P{XP}Hsp22d07618
NA
miscellaneous insertions
Mi{MIC}Hsp22MI06285
NA
P{GT1}Hsp22BG02409
NA
PBac{PB}Hsp22c06661
NA
insertion of enhancer trap binary system
P{GawB}Hsp22NP2055
No
P{GawB}Hsp22NP5403
No
hide Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
hide Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term
Evidence
References
determination of adult lifespan
inferred from mutant phenotype
(Morrow et al., 2004, Morrow et al., 2004)
response to heat
inferred from mutant phenotype
(Morrow et al., 2004)
response to oxidative stress
inferred from mutant phenotype
(Morrow et al., 2004)
Cellular Component ( 0 terms)
hide Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term
Evidence
References
protein refolding
non-traceable author statement
(Swiss-Prot Project Members, 1986.7.21)
response to heat
inferred from sequence or structural similarity with EMBL:U96099
(FlyBase, 1992-)
non-traceable author statement
(Swiss-Prot Project Members, 1986.7.21)
Cellular Component ( 0 terms)
hide Sequence Ontology: Class of Gene
gene_with_dicistronic_mRNA
(FlyBase Genome Annotators, 2002-2003)
nuclear_gene
 
protein_coding_gene
 
hide Interactions & Pathways
hide Summary of Physical Interactions
protein-protein
Interacting group
Assay
References
Hsp22 - 140up
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - Arpc4
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - Art2
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - Ate1
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - Atg18
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - Bx
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG10877
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG10996
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG11191
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG11504
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG11534
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG11679
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG11815
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG12084
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG12123
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG12289
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG13601
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG13900
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG14109
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG14262
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG14717
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG14891
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG15220
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG1561
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG15735
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG16815
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG16979
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG17565
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG17834
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG18004
experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting
(Guruharsha et al., 2011, Mintseris et al., 2009.11.23)
Hsp22 - CG2010
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG2076
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG2616
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG2812
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG30350
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG30487
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG3091
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG31229
experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting
(Guruharsha et al., 2011, Mintseris et al., 2009.11.23)
Hsp22 - CG31835
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG3224
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG3689
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG42678
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG4525
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG4810
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG5037
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG5718
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG5805
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG5840
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG5961
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG6034
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG6506
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG7168
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG7730
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG8026
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG8043
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG8520
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG8531
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG8678
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG8950
experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting
(Guruharsha et al., 2011, Mintseris et al., 2009.11.23)
Hsp22 - CG9062
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CG9596
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - Cdc5
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - Corp
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - Csp
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - CycA
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - FK506-bp2
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - Fmr1
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - Gad1
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - Gadd34
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - Gfrl
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - Gs1
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - GstE8
experimental knowledge based
(Guruharsha et al., 2011)
Hsp22 - Hcf
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - Hph
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - Hsp23
experimental knowledge based
(Guruharsha et al., 2011)
Hsp22 - Hsp26
experimental knowledge based
(Guruharsha et al., 2011)
Hsp22 - Hsp27
experimental knowledge based
(Guruharsha et al., 2011)
Hsp22 - Hsp68
experimental knowledge based
(Guruharsha et al., 2011)
Hsp22 - Hsp70Aa
experimental knowledge based
(Guruharsha et al., 2011)
Hsp22 - Imp
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - LKR
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - MRG15
anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
(Mintseris et al., 2009.11.23, Guruharsha et al., 2011)
Hsp22 - Mcm3
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - NHP2
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - Nle
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - Ns1
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - OdsH
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - Patsas
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - Pgam5
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - Pk17E
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - Pp2B-14D
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - Pp4-19C
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - Prosα7
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - Prosβ2R2
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - Rad9
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - RagC-D
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - Rbp1-like
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - Rpb4
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - Rpt1
experimental knowledge based
(Guruharsha et al., 2011)
Hsp22 - Rrp4
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - Saf-B
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - Shawn
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - Socs44A
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - TH1
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - Tgt
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - Trh
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - dpr5
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - eIF3-S8
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - eIF6
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - frc
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - hyd
experimental knowledge based
(Guruharsha et al., 2011)
Hsp22 - igl
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - kay
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - ldbr
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - mRpL44
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - mRpS24
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - morgue
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - mts
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - nmo
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - pic
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - ppa
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - ref(2)P
experimental knowledge based
(Guruharsha et al., 2011)
Hsp22 - sa
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - thoc7
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
Hsp22 - βTub85D
anti tag coimmunoprecipitation, peptide massfingerprinting
(Mintseris et al., 2009.11.23)
hide Summary of Genetic Interactions
Interacts with
Please look at the allele data for full details of the genetic interactions
Hsp22 allele
Gene
References
Hsp22EP3247
pnr
(Pena-Rangel et al., 2002)
hide External Data
Linkouts
BioGRID - A database of protein and genetic interactions
•
DPiM - DPiM, Drosophila Protein interaction Map
•
DroID - A comprehensive database of gene and protein interactions.
•
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
•
hide Orthologs
hide OrthoDB Orthologs (76) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
OrthoDB orthology group searches
(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)
Drosophila inclusive ortholog search
EOG6RXZKN
Dipteran inclusive ortholog search
No orthologs identified
Insect inclusive ortholog search
EOG6QZ6H9
Arthropod inclusive ortholog search
No orthologs identified
Metazoa inclusive ortholog search
EOG6FJN62
hideOrthologs in Drosophila Species (EOG6RXZKN)
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly 
 
 
Drosophila simulans
 
Y
 
Drosophila sechellia
 
Y
 
Drosophila erecta
 
Y
 
Drosophila yakuba
 
Y
 
Drosophila ananassae
 
Y
 
Drosophila pseudoobscura pseudoobscura
 
Y
 
Drosophila persimilis
 
Y
 
Drosophila willistoni
 
Y
 
Drosophila virilis
 
Y
 
Drosophila mojavensis
 
Y
 
Drosophila grimshawi
 
 
 
Drosophila grimshawi
 
Y
 
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
hideOrthologs in non-Dipteran Insects (EOG6QZ6H9)
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Tribolium castaneum
Red flour beetle 
 
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
hideOrthologs in non-Arthropod Metazoa (EOG6FJN62)
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Caenorhabditis elegans
Nematode 
Y
Caenorhabditis elegans
Nematode 
Y
Caenorhabditis elegans
Nematode 
Y
Caenorhabditis elegans
Nematode 
Y
Caenorhabditis elegans
Nematode 
Y
Caenorhabditis elegans
Nematode 
Y
Caenorhabditis elegans
Nematode 
Y
Caenorhabditis elegans
Nematode 
Y
Caenorhabditis elegans
Nematode 
Y
Caenorhabditis elegans
Nematode 
Y
Caenorhabditis elegans
Nematode 
Y
Caenorhabditis elegans
Nematode 
Y
Caenorhabditis elegans
Nematode 
Y
Strongylocentrotus purpuratus
Purple sea urchin 
Y
Strongylocentrotus purpuratus
Purple sea urchin 
Y
Strongylocentrotus purpuratus
Purple sea urchin 
Y
Danio rerio
Zebrafish 
Y
Danio rerio
Zebrafish 
Y
Danio rerio
Zebrafish 
Y
Danio rerio
Zebrafish 
Y
Danio rerio
Zebrafish 
Y
Danio rerio
Zebrafish 
Y
Danio rerio
Zebrafish 
Y
Danio rerio
Zebrafish 
Y
Danio rerio
Zebrafish 
Y
Danio rerio
Zebrafish 
Y
Xenopus tropicalis
Western clawed frog 
Y
Xenopus tropicalis
Western clawed frog 
Y
Xenopus tropicalis
Western clawed frog 
Y
Xenopus tropicalis
Western clawed frog 
Y
Xenopus tropicalis
Western clawed frog 
Y
Xenopus tropicalis
Western clawed frog 
Y
Xenopus tropicalis
Western clawed frog 
Y
Xenopus tropicalis
Western clawed frog 
Y
Gallus gallus
Domestic chicken 
Y
Gallus gallus
Domestic chicken 
Y
Gallus gallus
Domestic chicken 
Y
Gallus gallus
Domestic chicken 
Y
Gallus gallus
Domestic chicken 
Y
Gallus gallus
Domestic chicken 
Y
Mus musculus
House mouse 
Y
Mus musculus
House mouse 
Y
Mus musculus
House mouse 
Y
Mus musculus
House mouse 
Y
Mus musculus
House mouse 
Y
Mus musculus
House mouse 
Y
Mus musculus
House mouse 
Y
Rattus norvegicus
Norway rat 
Y
Rattus norvegicus
Norway rat 
Y
Rattus norvegicus
Norway rat 
Y
Rattus norvegicus
Norway rat 
Y
Rattus norvegicus
Norway rat 
Y
Rattus norvegicus
Norway rat 
Y
Rattus norvegicus
Norway rat 
Y
Homo sapiens
Human 
Y
Homo sapiens
Human 
Y
Homo sapiens
Human 
Y
Homo sapiens
Human 
Y
Homo sapiens
Human 
Y
Homo sapiens
Human 
Y
Homo sapiens
Human 
Y
Homo sapiens
Human 
Y
hide Human Orthologs (8)
Gene
OMIM
HGNC
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
hideAAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism
Gene
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
hide Stocks & Reagents
hide Stocks Listed in FlyBase ( 9 )
Bloomington
12683
w1118; P{GT1}Hsp22BG02409 Hsp67BbBG02409
42382
y1 w*; Mi{MIC}Hsp22MI06285 Hsp67BbMI06285
20055
y1 w67c23; P{EPgy2}Hsp22EY09909 Hsp67BbEY09909
Harvard
-
P{XP}Hsp22d00797
-
P{XP}Hsp22d07618
-
PBac{PB}Hsp22c06661
Kyoto
113720
w*; P{GawB}Hsp22NP5403 / TM6, P{UAS-lacZ.UW23-1}UW23-1
104072
w*; P{GawB}Hsp22NP2055 / TM3, Sb1 Ser1
VDRC
v43632
w1118; P{GD8704}v43632
hide Genomic Clones ( 1 )

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
hide cDNA Clones ( 16 )

Please Note
This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
hide RNAi & Array Information
Linkouts
DRSC - Results from RNAi screens.
•
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
•
hide Antibody Information
hide Other Information
hide Discoverer
hide Etymology
hide Identification
hide Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Dicistronic annotation CG32041 split out into separate annotations for each open reading frame, CG4456 and CG4460, in release 4.2 of the genome annotation. CG4456 corresponds to Hsp67Bb and CG4460 corresponds to Hsp22.
(FlyBase Genome Annotators, 2005)
One or more of the processed transcripts for this gene contain(s) two non-overlapping open reading frames (ORFs). The non-overlapping ORFs are represented by Hsp67Bb and Hsp22.
(FlyBase Genome Annotators, 2002-2003)
hide Other Comments
Expression is rapidly induced in the testis after heat stress. Activation of Hsp22 in testes and heads necessitates the presence of a functional Hsf.
(Michaud et al., 1997)
Increase in RNA levels is observed with aging.
(Wheeler et al., 1995)
Chromosome staining reveals that Trl and heat shock transcription factors (HSF) colocalises at Hsp22.
(Tsukiyama et al., 1994)
In vivo UV cross-linking and nuclear run-on assays shows that RNA polymerase II density on the Hsp22 gene is rapidly increased by heat shock.
(O'Brien and Lis, 1993)
In unshocked cells Hsp83 is moderately transcribed while transcription from the other heat shock genes is undetectable. Engaged but paused RNA molecules are found at the various Hsp70 and Hsp26 genes but not at the other heat shock genes. Increased transcription of the heat shock genes is observed within 1-2 mins of heat shock and maximal rates were reached within 2-5 minutes. Rates of transcription vary over a 20-fold range.
(Vazquez et al., 1993)
Exposure of cells to pulses of elevated temperature initiates the heat-shock response. A restricted subset of genes, the Hsp genes, is activated and the majority of transcription and translation is shut down. 3H-uridine incorporation ceases at its usual positions and commences at new puff sites. Preexisting polysomes disaggregate and within a few minutes a new population of polysomes appears containing newly transcribed mRNA; this RNA hybridizes to some of the heat-shock puffs. Similar response inducible by other stressful treatments. The response may be elicited at all stages of the life cycle and in cultured cells.
(Lindsley and Zimm, 1992)
Hsp22 regulatory regions involved in heat shock expression and ecdysterone-induced expression have been identified.
(Rudolph et al., 1991)
Translation of Hsp70 mRNAs and to a lesser extent the mRNAs for the small heat shock proteins is almost independent of eIF-4E.
(Zapata et al., 1991)
Mutations at br reduce the transcription rate or stability of the small heat shock protein mRNAs.
(Dubrovsky et al., 1990)
Heat shock induces the accumulation of a dicistronic mRNA which contains both the Hsp22 and Hsp67Bb open reading frames. Overall orientation not stated: Hsp27- Hsp23- Hsp67Ba+ Hsp26+ Hsp22- Hsp67Bb- Hsp67Bc+
(Pauli et al., 1988)
Heat-shock inducible in almost all cells at the stages tested.
(Ayme-Southgate and Tissieres, 1985)
Activation of transcription of Hsp genes apparently involves the sequential binding of two or more protein factors in vicinity of TATA box.
(Wu, 1984)
Polymerase II dissociates from most chromosome regions and accumulates at the new heat shock puff sites upon heat shock.
(Bonner and Kerby, 1982)
The binding sites for the protein factors required for activation of transcription of Hsp genes are multiple short upstream sequence elements called HSEs or heat shock consensus elements.
(Pelham, 1982, Xiao and Lis, 1988)
Hsp22 is transcribed during certain developmental stages in the absence of heat shock.
(Sirotkin and Davidson, 1982)
The effects of heat shock may be abrogated to some degree by pretreatment with a pulse of a slightly lower temperature.
(Mitchell et al., 1979, Petersen and Mitchell, 1981)
Mitochondrial and histone-gene activities persist transcription and translation.
(Spradling et al., 1977)
In polytene cells, during heat shock response, existing puffs regress and a novel group quickly appear at 33B, 63C, 64F, 67B, 70A, 87A, 87C, 93D, 95D.
(Tissieres et al., 1974)
The heat shock response follows a pulse of 36oC to 40oC; treatments above 40oC inhibit all activity and lead to death; treatments of 30oC-35oC induce heat-shock-protein synthesis without repressing normal protein synthesis.
(Tissieres et al., 1974)
In polytene cells, during heat shock response, existing puffs regress and a novel group quickly appear at cytological locations 33B, 63C, 64F, 67B, 70A, 87A, 87C, 93D, 95D.
(Ashburner, 1970)
hide External Crossreferences & Linkouts
Sequence Crossreferences
RefSeq (Transcripts)
•
RefSeq (Proteins)
•
DDBJ / EMBL / GenBank
•
Entrez Gene - A searchable database of RefSeq genes.
•
UniProtKB/Swiss-Prot
•
Other Crossreferences
EPD - Eukarytoic Promoter Database, an annotated collection of POL II promoters
•
InterPro domains - A database of protein families, domains, and functional sites
•
Alpha crystallin/Heat shock protein (IPR001436)
Alpha crystallin/Hsp20 domain (IPR002068)
HSP20-like chaperone (IPR008978)
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
•
Linkouts
BioGRID - A database of protein and genetic interactions
•
DPiM - DPiM, Drosophila Protein interaction Map
•
DroID - A comprehensive database of gene and protein interactions.
•
DRSC - Results from RNAi screens.
•
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
•
FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
•
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
•
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
•
modMine - Data generated by the modENCODE project.
•
hide Synonyms & Secondary IDs ( 15 )
Reported As
Symbol Synonym
22
(Petersen and Lindquist, 1988)
anon-WO0118547.50
 
anon-WO0140519.138
 
CG4460
 
CG32041
(Giot et al., 2003, Lai et al., 2007, Birch-Machin et al., 2005, Kim et al., 2010)
DmHsp22
(Morrow et al., 2000, Wadhwa et al., 2010)
EP(3)3247
(Pena-Rangel et al., 2002)
Hsp22
(Sudi et al., 2008, Geiger-Thornsberry and Mackay, 2004, Gruenewald et al., 2009, Morettini et al., 2011, Yepiskoposyan et al., 2006, Walser et al., 2006, Moskalev et al., 2009, Harvey et al., 2008, Takahashi et al., 2011, Gilchrist et al., 2008, Bettencourt et al., 2008, Morrow et al., 2004, Gim et al., 2001, Fernández-Ayala et al., 2010, Tian et al., 2010, Xi et al., 2008, Takahashi et al., 2010, Wadhwa et al., 2010, Colinet et al., 2010, Lorbeck et al., 2010, Kim et al., 2010, Neal et al., 2006, Duncan, 2005, Colinet et al., 2010, Groebe et al., 2010, Kim et al., 2010, Duncan, 2008, Hirano et al., 2012, Navarro et al., 2011, Thomas et al., 2012, Fredriksson et al., 2012)
hsp22
(Landis et al., 2004, Morrow et al., 2004, Kurapati et al., 2000, Aigaki et al., 2002, Bhole et al., 2001, Ayme-Southgate, 1993.2.23, Tatar, 1999, King and Tower, 1999, Otsuka et al., 1997, Shopland and Lis, 1996, Wheeler et al., 1995, Champlin and Lis, 1994, O'Brien and Lis, 1993, Molto et al., 1993, Heikkila, 1993, Vazquez et al., 1993, Pauli et al., 1992, Berger et al., 1992, Vazquez, 1991, Dobens et al., 1991, Zapata et al., 1991, Rudolph et al., 1991, Bendena et al., 1991, Yost et al., 1990, Ornelles and Penman, 1990, Thummel, 1990, Pauli et al., 1989, Pauli et al., 1988, Pauli and Tonka, 1987, Ayme-Southgate and Tissieres, 1985, Southgate et al., 1983, Ingolia and Craig, 1981, Bhole et al., 2004, Zhao et al., 2005, Hull-Thompson et al., 2009, Kurapati et al., 2004, Grover et al., 2009, Zhao et al., 2005, Yang and Tower, 2009, Morrow et al., 2004, Curtis et al., 2007, Chan et al., 2011, Sharma et al., 2011, Grover et al., 2008, Magdalena et al., 2012, Sharma et al., 2012)
small hsp locus 67B
(Yao et al., 2007)
Name Synonym
Heat shock protein 22
(Gim et al., 2001, Kim et al., 2010)
heat shock protein 22
(Lorbeck et al., 2010)
heat-shock protein 22
(Hirano et al., 2012)
heat shock protein hsp22
(Ingolia, 1985.2.22)
Protein 22
(Bournias-Vardiabasis et al., 1990)
Secondary FlyBase IDs
  • FBgn0044743
  • FBgn0052041
  • FBgn0061943
  • FBpp0076176
  • FBpp0076177
  • FBpp0076178
  • FBpp0076179
  • FBtr0076448
  • FBtr0076449
  • FBtr0076450
  • FBtr0076451
hide References ( 156 )
Generate a list of
List References by type
hide Recent research papers ( 13 )
Baradaran-Heravi et al., 2012, Hum. Mol. Genet. 21(11): 2572--2587
Penetrance of biallelic SMARCAL1 mutations is associated with environmental and genetic disturbances of gene expression. [FBrf0218299]
Fredriksson et al., 2012, Aging Cell 11(4): 634--643
Effects of aging and reproduction on protein quality control in soma and gametes of Drosophila melanogaster. [FBrf0218923]
Hirano et al., 2012, Genes Brain Behav. 11(1): 79--86
Reactive oxygen species are not involved in the onset of age-related memory impairment in Drosophila. [FBrf0217142]
Landis et al., 2012, Aging 4(11): 768--789
Gene expression changes in response to aging compared to heat stress, oxidative stress and ionizing radiation in Drosophila melanogaster. [FBrf0220226]
Magdalena et al., 2012, Genet. Mol. Res. 11(1): 739--745
Downregulation of hsp22 gene expression in Drosophila melanogaster from sites located near chemical plants. [FBrf0218293]
Mathieu et al., 2012, Nucleic Acids Res. 40(11): 4879--4891
Recruitment of the ATP-dependent chromatin remodeler dMi-2 to the transcribed region of active heat shock genes. [FBrf0219222]
Sharma et al., 2012, J. Hazard. Mater. 221-222: 275--287
Organochlorine pesticide, endosulfan induced cellular and organismal response in Drosophila melanogaster. [FBrf0218375]
Thomas et al., 2012, PLoS ONE 7(7): e40276
A Versatile Method for Cell-Specific Profiling of Translated mRNAs in Drosophila. [FBrf0218903]
Chan et al., 2011, Hum. Mol. Genet. 20(9): 1738--1750
Expanded polyglutamine domain possesses nuclear export activity which modulates subcellular localization and toxicity of polyQ disease protein via exportin-1. [FBrf0214367]
Morettini et al., 2011, Nucleic Acids Res. 39(8): 3103--3115
The chromodomains of CHD1 are critical for enzymatic activity but less important for chromatin localization. [FBrf0213515]
Navarro et al., 2011, PLoS ONE 6(7): e21017
Overexpression of human and fly frataxins in Drosophila provokes deleterious effects at biochemical, physiological and developmental levels. [FBrf0214483]
Sharma et al., 2011, Chemosphere 82(3): 370--376
Transcriptome analysis provides insights for understanding the adverse effects of endosulfan in Drosophila melanogaster. [FBrf0212610]
Takahashi et al., 2011, PLoS ONE 6(4): e17295
Environmental Stress-Dependent Effects of Deletions Encompassing Hsp70Ba on Canalization and Quantitative Trait Asymmetry in Drosophila melanogaster. [FBrf0213649]
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