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Gene Dmel\Hsp67Ba

General Information
Symbol	Dmel\Hsp67Ba	Species	D. melanogaster
Name	Heat shock gene 67Ba	Annotation symbol	CG4167
Feature type	protein_coding_gene	FlyBase ID	FBgn0001227
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	gene 1, gene1
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	67B2-67B2	Sequence location	3L:9,370,902..9,372,634 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Heat shock gene 67Ba is referred to in FlyBase by the symbol Dmel\Hsp67Ba (CG4167, FBgn0001227). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. Based on sequence similarity, it is predicted to be involved in the biological process: response to heat. 9 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Alpha crystallin/Heat shock protein; HSP20-like chaperone; Heat shock protein Hsp20. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval Malpighian tubules. Comments on Affy2 ProbeSet: ProbeSet 1638730_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Hsp67Ba. Gene sequence location is 3L:9370902..9372634.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Hsp22 - Hsp-G3 There are seven closely related heat-shock genes at 67B (Ayme and Tissieres, 1985; Pauli, Arrigo, Vasquez, Tonka, and Tissieres, 1989, Genome 31: 671-76). In addition to the four small heat-shock genes previously identified (Hsp22, Hsp23, Hsp26, and Hsp27), three more genes (Hsp-G1, Hsp-G2, and Hsp-G3, formerly called Gene1, Gene2, and Gene3) have been found clustered within 15 kb of DNA at the same 67B cytological location. All seven genes are heat-shock inducible in almost all cells at the stages tested (Ayme and Tissieres, 1985). The genes are also transcribed during certain developmental stages in the absence of heat shock (Sirotkin and Davidson, 1982, Dev. Biol. 89: 196-210). Pauli et al (1989) report that the maximum accumulation of developmental rRNA in a majority of these small heat-shock genes occurs in the white pupae stage; in Hsp-G2, however, a small transcipt is found in embryos, first and second instar larvae, and young pupae; and a larger transcript in the pupal and adult stages of males (Pauli and Tonka, 1987, J. Mol. Biol. 198: 235-40; Pauli, Tonka, and Ayme-Southgate, 1988, J. Mol. Biol. 200: 47-53). In absence of stress, the expression of Hsp26 has been observed in spermatocytes, nurse cells, epithelium, imaginal discs, proventriculus, and neurocytes (Glaser, Wolfner, and Lis, 1986, EMBO 5: 747-54). Transcripts of Hsp26 and Hsp27 accumulate in adult ovaries, apparently originating in nurse cells (Zimmerman, Petri, and Meselson, 1983, Cell 32: 1161-70).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features BKN24917 HFA11191
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 67B2-67B2   Limits computationally determined from genome sequence between P{EP}Hsp26EP3336&P{EP}Hsp26EP3315 and P{PZ}fry02240
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Hsp67Ba for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.41
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Hsp67Ba-RA FBtr0076495  NM_079274   1733   445
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Hsp67Ba-PA   FBpp0076223   46.9   445   4.35     NP_523998   AAF50287
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Alpha crystallin/Heat shock protein (IPR001436) Heat shock protein Hsp20 (IPR002068) HSP20-like chaperone (IPR008978)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141670   AA141671   AE014296 AAF50287   BT016062 AAV36947   CO180521   M26267 AAA28634
UniProtKB/Swiss-Prot	P05812
UniProtKB/TrEMBL	Q5U130
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference prepupal stage     (Pauli et al., 1989)
Additional Descriptive Data
	Maximal Hsp67Ba transcript expression is reached in white prepupae. (Pauli et al., 1989)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0001227    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0001227 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0001227 expression level Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    42 embryo 04-06hr    55 embryo 06-08hr    108 embryo 08-10hr    97 embryo 10-12hr    267 embryo 12-14hr    163 embryo 14-16hr    162 embryo 16-18hr    78 embryo 18-20hr    28 embryo 20-22hr    14 embryo 22-24hr    11 larva L1    30 larva L2    84 larva L3 12hr old    152 larva L3 puffstage 1-2    855 larva L3 puffstage 3-6    2483 larva L3 puffstage 7-9    3971 white prepupae new    7234 white prepupae 12hr    12575 white prepupae 24hr    15047 pupae 2d postWPP    8385 pupae 3d postWPP    793 pupae 4d postWPP    2478 adult male 01day    401 adult male 05day    484 adult male 30day    446 adult female 01day    287 adult female 05day    133 adult female 30day    122 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    42 embryo 04-06hr    55 embryo 06-08hr  (108) embryo 08-10hr    97 embryo 10-12hr  (267) embryo 12-14hr  (163) embryo 14-16hr  (162) embryo 16-18hr    78 embryo 18-20hr    28 embryo 20-22hr    14 embryo 22-24hr    11 larva L1    30 larva L2    84 larva L3 12hr old  (152) larva L3 puffstage 1-2  (855) larva L3 puffstage 3-6  (2483) larva L3 puffstage 7-9  (3971) white prepupae new  (7234) white prepupae 12hr  (12575) white prepupae 24hr  (15047) pupae 2d postWPP  (8385) pupae 3d postWPP  (793) pupae 4d postWPP  (2478) adult male 01day  (401) adult male 05day  (484) adult male 30day  (446) adult female 01day  (287) adult female 05day  (133) adult female 30day  (122) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    42 embryo 04-06hr    55 embryo 06-08hr    108 embryo 08-10hr    97 embryo 10-12hr    267 embryo 12-14hr    163 embryo 14-16hr    162 embryo 16-18hr    78 embryo 18-20hr    28 embryo 20-22hr    14 embryo 22-24hr    11 larva L1    30 larva L2    84 larva L3 12hr old    152 larva L3 puffstage 1-2    855 larva L3 puffstage 3-6  (2483) larva L3 puffstage 7-9  (3971) white prepupae new  (7234) white prepupae 12hr  (12575) white prepupae 24hr  (15047) pupae 2d postWPP  (8385) pupae 3d postWPP    793 pupae 4d postWPP  (2478) adult male 01day    401 adult male 05day    484 adult male 30day    446 adult female 01day    287 adult female 05day    133 adult female 30day    122 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    42 embryo 04-06hr    55 embryo 06-08hr    108 embryo 08-10hr    97 embryo 10-12hr    267 embryo 12-14hr    163 embryo 14-16hr    162 embryo 16-18hr    78 embryo 18-20hr    28 embryo 20-22hr    14 embryo 22-24hr    11 larva L1    30 larva L2    84 larva L3 12hr old    152 larva L3 puffstage 1-2    855 larva L3 puffstage 3-6    2483 larva L3 puffstage 7-9    3971 white prepupae new    7234 white prepupae 12hr  (12575) white prepupae 24hr  (15047) pupae 2d postWPP    8385 pupae 3d postWPP    793 pupae 4d postWPP    2478 adult male 01day    401 adult male 05day    484 adult male 30day    446 adult female 01day    287 adult female 05day    133 adult female 30day    122 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    42 embryo 04-06hr    55 embryo 06-08hr    108 embryo 08-10hr    97 embryo 10-12hr    267 embryo 12-14hr    163 embryo 14-16hr    162 embryo 16-18hr    78 embryo 18-20hr    28 embryo 20-22hr    14 embryo 22-24hr    11 larva L1    30 larva L2    84 larva L3 12hr old    152 larva L3 puffstage 1-2    855 larva L3 puffstage 3-6    2483 larva L3 puffstage 7-9    3971 white prepupae new    7234 white prepupae 12hr    12575 white prepupae 24hr    15047 pupae 2d postWPP    8385 pupae 3d postWPP    793 pupae 4d postWPP    2478 adult male 01day    401 adult male 05day    484 adult male 30day    446 adult female 01day    287 adult female 05day    133 adult female 30day    122 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0001227 expression level Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    42 embryo 04-06hr    55 embryo 06-08hr    108 embryo 08-10hr    97 embryo 10-12hr    267 embryo 12-14hr    163 embryo 14-16hr    162 embryo 16-18hr    78 embryo 18-20hr    28 embryo 20-22hr    14 embryo 22-24hr    11 larva L1    30 larva L2    84 larva L3 12hr old    152 larva L3 puffstage 1-2    855 larva L3 puffstage 3-6    2483 larva L3 puffstage 7-9    3971 white prepupae new    7234 white prepupae 12hr    12575 white prepupae 24hr    15047 pupae 2d postWPP    8385 pupae 3d postWPP    793 pupae 4d postWPP    2478 adult male 01day    401 adult male 05day    484 adult male 30day    446 adult female 01day    287 adult female 05day    133 adult female 30day    122 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    42 embryo 04-06hr    55 embryo 06-08hr  108 embryo 08-10hr    97 embryo 10-12hr  (267) embryo 12-14hr  (163) embryo 14-16hr  (162) embryo 16-18hr    78 embryo 18-20hr    28 embryo 20-22hr    14 embryo 22-24hr    11 larva L1    30 larva L2    84 larva L3 12hr old  (152) larva L3 puffstage 1-2  (855) larva L3 puffstage 3-6  (2483) larva L3 puffstage 7-9  (3971) white prepupae new  (7234) white prepupae 12hr  (12575) white prepupae 24hr  (15047) pupae 2d postWPP  (8385) pupae 3d postWPP  (793) pupae 4d postWPP  (2478) adult male 01day  (401) adult male 05day  (484) adult male 30day  (446) adult female 01day  (287) adult female 05day  133 adult female 30day  122 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    42 embryo 04-06hr    55 embryo 06-08hr    108 embryo 08-10hr    97 embryo 10-12hr    267 embryo 12-14hr    163 embryo 14-16hr    162 embryo 16-18hr    78 embryo 18-20hr    28 embryo 20-22hr    14 embryo 22-24hr    11 larva L1    30 larva L2    84 larva L3 12hr old    152 larva L3 puffstage 1-2    855 larva L3 puffstage 3-6  (2483) larva L3 puffstage 7-9  (3971) white prepupae new  (7234) white prepupae 12hr  (12575) white prepupae 24hr  (15047) pupae 2d postWPP  (8385) pupae 3d postWPP    793 pupae 4d postWPP  (2478) adult male 01day    401 adult male 05day    484 adult male 30day    446 adult female 01day    287 adult female 05day    133 adult female 30day    122 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    42 embryo 04-06hr    55 embryo 06-08hr    108 embryo 08-10hr    97 embryo 10-12hr    267 embryo 12-14hr    163 embryo 14-16hr    162 embryo 16-18hr    78 embryo 18-20hr    28 embryo 20-22hr    14 embryo 22-24hr    11 larva L1    30 larva L2    84 larva L3 12hr old    152 larva L3 puffstage 1-2    855 larva L3 puffstage 3-6    2483 larva L3 puffstage 7-9    3971 white prepupae new    7234 white prepupae 12hr  12575 white prepupae 24hr  15047 pupae 2d postWPP    8385 pupae 3d postWPP    793 pupae 4d postWPP    2478 adult male 01day    401 adult male 05day    484 adult male 30day    446 adult female 01day    287 adult female 05day    133 adult female 30day    122 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    39 embryo 02-04hr    42 embryo 04-06hr    55 embryo 06-08hr    108 embryo 08-10hr    97 embryo 10-12hr    267 embryo 12-14hr    163 embryo 14-16hr    162 embryo 16-18hr    78 embryo 18-20hr    28 embryo 20-22hr    14 embryo 22-24hr    11 larva L1    30 larva L2    84 larva L3 12hr old    152 larva L3 puffstage 1-2    855 larva L3 puffstage 3-6    2483 larva L3 puffstage 7-9    3971 white prepupae new    7234 white prepupae 12hr    12575 white prepupae 24hr    15047 pupae 2d postWPP    8385 pupae 3d postWPP    793 pupae 4d postWPP    2478 adult male 01day    401 adult male 05day    484 adult male 30day    446 adult female 01day    287 adult female 05day    133 adult female 30day    122 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0001227    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0001227 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system, larval Malpighian tubules. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0001227 expression level Tissue   Expression Level Larval Central Nervous System    382.575 Larval Midgut no informative data Larval Hindgut    5.3 Larval Malpighian Tubules    191.4 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye    8.075 Adult Brain    131.7 Adult Thoracic-Abdominal Ganglion    182.7 Adult Crop    5.2 Adult Midgut    5.5 Adult Hindgut    4.2 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    7.45 Adult VirginFemale Spermatheca    9.8 Adult InseminatedFemale Spermatheca    8.9 Adult Ovary    3.3 Adult Testis    36 Adult Male Accessory Gland    9.1 Adult Carcass    3.7 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    382.575 Larval Midgut no informative data Larval Hindgut    5.3 Larval Malpighian Tubules    191.4 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye    8.075 Adult Brain    131.7 Adult Thoracic-Abdominal Ganglion    182.7 Adult Crop    5.2 Adult Midgut    5.5 Adult Hindgut    4.2 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    7.45 Adult VirginFemale Spermatheca    9.8 Adult InseminatedFemale Spermatheca    8.9 Adult Ovary    3.3 Adult Testis    36 Adult Male Accessory Gland    9.1 Adult Carcass    3.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    382.575 Larval Midgut no informative data Larval Hindgut    5.3 Larval Malpighian Tubules    191.4 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye    8.075 Adult Brain    131.7 Adult Thoracic-Abdominal Ganglion    182.7 Adult Crop    5.2 Adult Midgut    5.5 Adult Hindgut    4.2 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    7.45 Adult VirginFemale Spermatheca    9.8 Adult InseminatedFemale Spermatheca    8.9 Adult Ovary    3.3 Adult Testis    36 Adult Male Accessory Gland    9.1 Adult Carcass    3.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    382.575 Larval Midgut no informative data Larval Hindgut    5.3 Larval Malpighian Tubules    191.4 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye    8.075 Adult Brain    131.7 Adult Thoracic-Abdominal Ganglion    182.7 Adult Crop    5.2 Adult Midgut    5.5 Adult Hindgut    4.2 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    7.45 Adult VirginFemale Spermatheca    9.8 Adult InseminatedFemale Spermatheca    8.9 Adult Ovary    3.3 Adult Testis    36 Adult Male Accessory Gland    9.1 Adult Carcass    3.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0001227 expression level Tissue   Expression Level Larval Central Nervous System    382.575 Larval Midgut no informative data Larval Hindgut    5.3 Larval Malpighian Tubules    191.4 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye    8.075 Adult Brain    131.7 Adult Thoracic-Abdominal Ganglion    182.7 Adult Crop    5.2 Adult Midgut    5.5 Adult Hindgut    4.2 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    7.45 Adult VirginFemale Spermatheca    9.8 Adult InseminatedFemale Spermatheca    8.9 Adult Ovary    3.3 Adult Testis    36 Adult Male Accessory Gland    9.1 Adult Carcass    3.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    382.575 Larval Midgut no informative data Larval Hindgut    5.3 Larval Malpighian Tubules    191.4 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye    8.075 Adult Brain    131.7 Adult Thoracic-Abdominal Ganglion    182.7 Adult Crop    5.2 Adult Midgut    5.5 Adult Hindgut    4.2 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    7.45 Adult VirginFemale Spermatheca    9.8 Adult InseminatedFemale Spermatheca    8.9 Adult Ovary    3.3 Adult Testis    36 Adult Male Accessory Gland    9.1 Adult Carcass    3.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    382.575 Larval Midgut no informative data Larval Hindgut    5.3 Larval Malpighian Tubules    191.4 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye    8.075 Adult Brain    131.7 Adult Thoracic-Abdominal Ganglion    182.7 Adult Crop    5.2 Adult Midgut    5.5 Adult Hindgut    4.2 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    7.45 Adult VirginFemale Spermatheca    9.8 Adult InseminatedFemale Spermatheca    8.9 Adult Ovary    3.3 Adult Testis    36 Adult Male Accessory Gland    9.1 Adult Carcass    3.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    382.575 Larval Midgut no informative data Larval Hindgut    5.3 Larval Malpighian Tubules    191.4 Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye    8.075 Adult Brain    131.7 Adult Thoracic-Abdominal Ganglion    182.7 Adult Crop    5.2 Adult Midgut    5.5 Adult Hindgut    4.2 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    7.45 Adult VirginFemale Spermatheca    9.8 Adult InseminatedFemale Spermatheca    8.9 Adult Ovary    3.3 Adult Testis    36 Adult Male Accessory Gland    9.1 Adult Carcass    3.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    8.075   NA  Brain    131.7   382.575  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    182.7   NA  Crop    5.2   no informative data  Midgut    5.5   5.3  Hindgut    4.2   191.4  Malpighian Tubules    no informative data   no informative data  Fat Body    no informative data   no informative data  Salivary Gland    no informative data   NA  Heart    7.45   no informative data  Trachea    NA   NA  VirginFemale Spermatheca    9.8   NA  InseminatedFemale Spermatheca    8.9   NA  Ovary    3.3   NA  Testis    36   NA  Male Accessory Gland    9.1   no informative data  Carcass    3.7 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_25
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001227 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4167-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 Hsp67BaGD11237 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 Hsp67BaGD11237 Phenotype manifest in Allele chaeta | supernumerary, with Scer\GAL4pnr-MD237 Hsp67BaGD11237
Classical Alleles ( 7 )
For All Classical Alleles Show
Allele of Hsp67Ba Class Mutagen Stocks Known lesion Hsp67Ba5-HA-5087 1 -- Hsp67BaC291 1 -- Hsp67Bae00339 1 -- Hsp67Bae02791 1 -- Hsp67Baf05424 1 -- Hsp67Baf05886 0 -- Hsp67Baf07632 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Hsp67Ba Class Mutagen Stocks Known lesion Hsp67BaGD11237 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Hsp67BaKK103957 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11237} NA P{KK103957} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{RS5}Hsp67Ba5-HA-5087 NA PBac{3HPy+}Hsp67BaC291 NA PBac{RB}Hsp67Bae00339 NA PBac{RB}Hsp67Bae02791 NA PBac{WH}Hsp67Baf05424 NA PBac{WH}Hsp67Baf05886 NA PBac{WH}Hsp67Baf07632 NA
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
response to heat inferred from sequence or structural similarity with EMBL:U96099 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1988.11.1)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Hsp67Ba allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64471 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0001227 DroID - A comprehensive database of gene and protein interactions. • FBgn0001227 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39076
Orthologs
Genome-wide drosophilid orthologs	Dana\GF23738 Dere\GG14046 Dgri\GH14699 Dmoj\GI12246 Dper\GL22631 Dpse\GA18002 Dsec\GM24880 Dsim\GD12932 Dvir\GJ11478 Dwil\GK16565 Dyak\GE21249
Curated drosophilid orthologs	Dpse\GA18002
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • 235846 Daphnia pulex (daphnia)
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	16329 y1 w1118; PBac{3HPy+}Hsp67BaC291
Harvard	- PBac{RB}Hsp67Bae00339 - PBac{RB}Hsp67Bae02791 - PBac{WH}Hsp67Baf05424
Kyoto	125821 w1118; P{RS5}Hsp67Ba5-HA-5087
VDRC	v104341 P{KK103957}VIE-260B v21806 w1118; P{GD11237}v21806 v21807 w1118; P{GD11237}v21807
Genomic Clones ( 1 )
	BACR01E20 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 4 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LP13637
Other clones	DPiM_LP13637
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	CK02209 EC02002
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0001227 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39076
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	In unshocked cells Hsp83 is moderately transcribed while transcription from the other heat shock genes is undetectable. Engaged but paused RNA molecules are found at the various Hsp70 and Hsp26 genes but not at the other heat shock genes. Increased transcription of the heat shock genes is observed within 1-2 mins of heat shock and maximal rates were reached within 2-5 minutes. Rates of transcription vary over a 20-fold range. (Vazquez et al., 1993) Exposure of cells to pulses of elevated temperature initiates the heat-shock response. A restricted subset of genes, the Hsp genes, is activated and the majority of transcription and translation is shut down. 3H-uridine incorporation ceases at its usual positions and commences at new puff sites. Preexisting polysomes disaggregate and within a few minutes a new population of polysomes appears containing newly transcribed mRNA; this RNA hybridizes to some of the heat-shock puffs. Similar response inducible by other stressful treatments. The response may be elicited at all stages of the life cycle and in cultured cells. (Lindsley and Zimm, 1992) In contrast to other heat shock genes, the response of Hsp67Ba to stress is modulated during development. (Vazquez, 1991) Hsp67Ba has been sequenced, and shows homology to the small heat shock genes Hsp22, Hsp23, Hsp26 and Hsp27. It is heat inducible. (Ayme-Southgate and Tissieres, 1985) Activation of transcription of Hsp genes apparently involves the sequential binding of two or more protein factors in vicinity of TATA box. (Wu, 1984) Polymerase II dissociates from most chromosome regions and accumulates at the new heat shock puff sites upon heat shock. (Bonner and Kerby, 1982) The binding sites for the protein factors required for activation of transcription of Hsp genes are multiple short upstream sequence elements called HSEs or heat shock consensus elements. (Pelham, 1982, Xiao and Lis, 1988) Hsp67Ba is transcribed during certain developmental stages in the absence of heat shock. (Sirotkin and Davidson, 1982) The effects of heat shock may be abrogated to some degree by pretreatment with a pulse of a slightly lower temperature. (Mitchell et al., 1979, Petersen and Mitchell, 1981) Mitochondrial and histone-gene activities persist transcription and translation. (Spradling et al., 1977) In polytene cells, during heat shock response, existing puffs regress and a novel group quickly appear at 33B, 63C, 64F, 67B, 70A, 87A, 87C, 93D, 95D. (Tissieres et al., 1974) The heat shock response follows a pulse of 36oC to 40oC; treatments above 40oC inhibit all activity and lead to death; treatments of 30oC-35oC induce heat-shock-protein synthesis without repressing normal protein synthesis. (Tissieres et al., 1974) In polytene cells, during heat shock response, existing puffs regress and a novel group quickly appear at cytological locations 33B, 63C, 64F, 67B, 70A, 87A, 87C, 93D, 95D. (Ashburner, 1970)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079274 RefSeq (Proteins) • NP_523998 DDBJ / EMBL / GenBank • AAA28634 AAF50287 AAV36947 BT016062 M26267 Entrez Gene - A searchable database of RefSeq genes. • 39076 UniProtKB/Swiss-Prot • P05812 UniProtKB/TrEMBL • Q5U130
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Alpha crystallin/Heat shock protein (IPR001436) Heat shock protein Hsp20 (IPR002068) HSP20-like chaperone (IPR008978)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64471 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0001227 DroID - A comprehensive database of gene and protein interactions. • FBgn0001227 DRSC - Results from RNAi screens. • FBgn0001227 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001227 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4167-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0001227 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39076 InParanoid A subset of ortholog calls from InParanoid. • 235846 Daphnia pulex (daphnia) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39076 modMine - Data generated by the modENCODE project. • FBgn0001227
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG4167 (Whitfield, 2001.1.5, Keleman et al., 2009.8.5) DROHSP (Schug et al., 1998) DROHSP1 (Schug et al., 1997) gene1 (Chung et al., 1993, Southgate et al., 1985) gene 1 (Rogulski and Cartwright, 1995, Vazquez et al., 1993, Vazquez, 1991, Elgin, 1990, Pauli et al., 1989, Pauli et al., 1988, Ayme-Southgate and Tissieres, 1985) Hsp67Ba (Sudi et al., 2008, Walser et al., 2006, Bettencourt et al., 2008, Birch-Machin et al., 2005, Blanco et al., 2008, Takahashi et al., 2010, Colinet et al., 2010, Wasbrough et al., 2010) Hsp-G1   small hsp locus 67B (Yao et al., 2007)
Name Synonym	Gene 1 (Pauli and Tonka, 1987) Heat shock gene 67Ba
Secondary FlyBase IDs
	FBgn0026837
References ( 49 )
Generate a list of	All references relating to this gene ( 49 )
List References by type	Research paper  ( 31 ) Supplementary material  ( 4 ) Review  ( 1 ) Personal communication to FlyBase  ( 4 ) Abstract  ( 1 ) FlyBase analysis  ( 2 ) Book  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 3 )
	Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Colinet et al., 2010, FEBS J. 277(1): 174--185 Temporal expression of heat shock genes during cold stress and recovery from chill coma in adult Drosophila melanogaster. [FBrf0209693] Takahashi et al., 2010, BMC Evol. Biol. 10: 284 Effects of small Hsp genes on developmental stability and microenvironmental canalization. [FBrf0211941] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...