l(3)L3852, IDH-NADP, IDH1, ICDH
phenotype _______________________ allele synonym ref α residual heterodimer activity formation _______________________________________________________ IdhF Idh6 3, 4 IdhnGB1 2, 6, 7 0 + IdhnGB2 IdhGB2 1, 2, 6, 7 5% β - IdhnNC1 2, 6, 7 0 + IdhS Idh4 3, 4 IdhSS Idh2 5 α 1 = Bentley, Meidinger, and Williamson, 1983, Biochem. Genet. 21: 725-33; 2 = Burkhart, Montgomery, Langley, and Voelker, 1984, Genetics 107: 295-306; 3 = Fox, 1970, DIS 45: 35; 4 = Fox, 1971, Biochem. Genet. 5: 69-80; 5 = Fox, 1972, DIS 48: 20; 6 = Langley, Voelker, Leigh Brown, Ohnishi, Dickson, and Montgomery, 1981, Genetics 99: 151- 56; 7 = Voelker, Langley, Leigh Brown, Ohnishi, Dickson, and Montgomery, and Smith, 1980 Proc. Nat. Acad. USA 77: 1091- 95. β 24% wild-type levels of CRM; kinetic properties of residual activity indistinguishable from those of wild type.
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.46
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Idh using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Idh in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of Idh l(3)L3852 was map position and function ( date:020805 ).
Source for merge of l(3)L3852 CG7176 was a shared cDNA (GH01524) ( date:011030 ).
CG7176 encodes a putative cytoplasmic form of IDH.
The relationship between survival, sex and Idh phenotypes is submitted to the paraquat bioassay and results show an intersection between the way in which oxidative damage affects bioenergetic pathways and its influence on the development and aging processes.
Structural gene or genes for NADP+-dependent isocitrate dehydrogenase <up>threo-D- isocitrate:NADP+ oxydoreductase (decarboxylating)</up> (IDH).
Studies of purified enzyme indicate it to have a molecular weight of 110,000 and to be a dimer of subunits with molecular weights 60,000 and 50,000.