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General Information
Symbol
Dmel\if
Species
D. melanogaster
Name
inflated
Annotation Symbol
CG9623
Feature Type
FlyBase ID
FBgn0001250
Gene Model Status
Stock Availability
Gene Snapshot
inflated (if) encodes one of five fly integrin alpha subunits, and when in a heterodimer with an integrin beta subunit makes a receptor for extracellular matrix proteins containing an RGD motif, such as those encoded by Tig, wb laminin and Tsp. It is required in numerous tissues for cell migration and adhesion between cell layers. [Date last reviewed: 2019-03-07]
Also Known As
αPS2, αPS2, PS2, αPS2 integrin, PS2α
Key Links
Genomic Location
Cytogenetic map
Sequence location
X:16,752,189..16,783,434 [-]
Recombination map
1-55
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the integrin alpha chain family. (P12080)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
Predictions / Assertions
-
Summaries
Gene Group (FlyBase)
INTEGRINS -
Integrins are heterodimeric transmembrane receptors composed of an α and β subunit that mediate cell-cell and cell-extracellular matrix adhesion. As well as maintaining tissue integrity, they are involved in morphogenesis and development. (Adapted from FBrf0167428).
Protein Function (UniProtKB)
Alpha-PS2/beta-PS is a receptor for Tig, wb and Ten-m. Involved in the function and/or development of the olfactory system.
(UniProt, P12080)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
if: inflated
Structural gene for the α-subunit of position specific integrin 2 (PS2), a large transmembrane protein (Bogaert et al., 1987). The β-subunit can associate with either of the two α-subunits, PS1 or PS2 (Brower et al., 1984; Wilcox, Brown, Piovant, Smith, and White, 1984, EMBO J. 3: 2307-13). Both α and β integrin are expressed in embryonic and larval tissues. In early development, PS2 is found in the mesoderm, localized to muscle attachments (Bogaert et al., 1987). Later, PS1 is expressed in the presumptive dorsal epithelium of the third instar imaginal wing discs; also, PS2 is found in the ventral epithelium, both integrins being important for the joining of the dorsal and ventral surfaces of the wing blade (Brower and Jaffe, 1989). Null mutations cause embryonic lethality (Wilcox, DiAntonio, and Leptin). In the mutant if1, the adult wing is inflated with lymph and smaller than normal; venation is defective. Wings later become dry and blistered.
if3
Longitudinal veins thickened, especially at wing base. Anterior crossvein thickened. if3/if3 flies show reduced levels of PS2 integrin on the surfaces of some imaginal disc cells (especially in the ventral region), but levels of this integrin in muscle, salivary glands, and most other tissues seem to be normal (Brower and Jaffe, 1989). Adult wings typically show large round wing blisters, but the penetrance of this phenotype in homo- and hemizygotes is variable. if3/ifk27e flies show an increase in penetrance (from 15-20% in homozygotes to 60-70% in the heteroalleles); penetrance is reduced in if3/ifk27e flies by low temperature and crowding (Brower and Jaffe, 1989).
ifN
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\if or the JBrowse view of Dmel\if for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Low-frequency RNA-Seq exon junction(s) not annotated.
Supported by strand-specific RNA-Seq data.
Gene model reviewed during 5.52
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0074357
5724
1396
FBtr0301352
5649
1371
FBtr0301353
5683
1396
FBtr0301354
5818
1396
Additional Transcript Data and Comments
Reported size (kB)
5.7 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0074131
154.3
1396
6.10
FBpp0290566
151.6
1371
6.04
FBpp0290567
154.3
1396
6.10
FBpp0290568
154.3
1396
6.10
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1396 aa isoforms: if-PB, if-PD, if-PF
Additional Polypeptide Data and Comments
Reported size (kDa)
1394 (aa); 140 (kD observed)
Comments
External Data
Subunit Structure (UniProtKB)
Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-PS2 associates with beta-PS.
(UniProt, P12080)
Post Translational Modification
The heavy-light chain cleavage site is either in 1230-1231, or 1233-1234, or 1243-1244.
(UniProt, P12080)
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\if using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (33 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (0 terms)
Biological Process (24 terms)
Terms Based on Experimental Evidence (17 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from expression pattern
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (8 terms)
CV Term
Evidence
References
Cellular Component (6 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
non-traceable author statement
inferred from sequence or structural similarity
traceable author statement
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
radioisotope in situ
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
if transcripts are expressed throughout development and in adults. In embryos, they are first detected at stage 4 in the presumptive mesoderm. They continue to be expressed in mesodermal cells after invagination. In third instar larval wing discs, if transcripts are primarily restricted to the ventral compartment and to the peripodial membrane.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
if accumulates at the transitory, anterior attachment site of dorsal acute muscle 3 of stage 14 embryos, and is lost after the final attachment sites are selected by stage 16.
if staining is seen in follicle cell membranes by staining of unfixed, unpermeabilized ovaries followed by fixation and dissection.
if protein is first detected in stage 10 embryos in the mesoderm where it is basally concentrated in cuboidal cells which lie on the ectoderm. After the somatic and visceral mesoderm separates, if protein is found on the basal cell surfaces of the visceral myoblasts when they attach to the foregut, midgut, and hindgut. It is also found at the sites of attachment of the somatic muscles. Protein was also detected in the gonadal sheath and in the interstitial cells of the gonad In third instar larval wing discs, if protein is primarily restricted to the ventral compartment.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\if in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 56 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 25 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of if
Transgenic constructs containing regulatory region of if
Deletions and Duplications ( 30 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
filopodium & abdominal ventral longitudinal muscle 3
muscle attachment site & basal lamina
muscle attachment site & connecting hemi-adherens junction
muscle attachment site & muscle tendon junction
sarcomere & somatic muscle
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (15)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
12 of 15
Yes
Yes
 
11 of 15
No
Yes
10 of 15
No
Yes
 
9 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
 
1 of 15
No
No
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (16)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
12 of 15
Yes
Yes
11 of 15
No
Yes
10 of 15
No
Yes
9 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
Yes
2 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (14)
11 of 13
Yes
Yes
5 of 13
No
Yes
3 of 13
No
Yes
3 of 13
No
Yes
2 of 13
No
No
2 of 13
No
No
2 of 13
No
No
2 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (5)
7 of 12
Yes
Yes
6 of 12
No
Yes
5 of 12
No
Yes
3 of 12
No
Yes
2 of 12
No
Yes
Danio rerio (Zebrafish) (19)
11 of 15
Yes
Yes
7 of 15
No
Yes
6 of 15
No
Yes
4 of 15
No
Yes
2 of 15
No
No
2 of 15
No
No
2 of 15
No
No
2 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
13 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (1)
1 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091900RZ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500OH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01PT )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01NQ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G02JI )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (4)
3 of 10
2 of 10
2 of 10
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 3 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-PS2 associates with beta-PS.
    (UniProt, P12080 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    X
    Recombination map
    1-55
    Cytogenetic map
    Sequence location
    X:16,752,189..16,783,434 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    15A5-15A7
    Limits computationally determined from genome sequence between P{EP}EP1547EP1547 and P{EP}CG4928EP1341
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    15A1-15A5
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Left of (cM)
    Notes
    Stocks and Reagents
    Stocks (15)
    Genomic Clones (24)
    cDNA Clones (37)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       
      monoclonal, polyclonal
      Commercially Available Antibodies
       
      Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for database merge of
      Additional comments
      Other Comments
      ChEST reveals this is a target of Mef2.
      dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
      RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in S2R+ cells: cells become round and detached. Kc167 cells are unaffected.
      if is required in the visceral mesoderm for normal migration of the endodermal midgut cells over the visceral mesoderm in the developing embryo.
      Class I and class II alleles fully complement class IV alleles. Class II alleles fully complement class III alleles. if13ts class I allele fully complements class II alleles, but the transheterozygotes between other class I alleles and class III allele generally die, although a few adult escapers are observed.
      Mutational analysis reveals if is required for the development of the adult halteres and legs, as well as the wing. if is required for the formation of the somatic muscle sarcomeric structure, rather than for its maintenance. The function of if in the morphogenesis of the midgut and nerve cord is distinct from its function in muscle attachment and sarcomeric structure.
      The functional significance of the cytoplasmic domains of the if, mew and mys subunits of the Position Specific (PS) integrin family are studied by analysing the relationship between the cytoplasmic domain structure and function in the context of a developing organism. The cytoplasmic tail of if is essential for both embryonic and postembryonic processes.
      Modulation of integrin function through the cytoplasmic domain of if is essential for embryonic morphogenesis.
      if is essential for the adhesion of muscle and epidermal hemiadherens junctions to extracellular matrix at muscle attachment sites in the developing embryo.
      The ability of two different integrin α subunits (encoded by mew and if) to substitute for each other during embryonic development has been studied. The two α subunits encoded by mew and if are not equivalent and have distinct functions which reside in the extracellular domains.
      Clonal analysis demonstrates that the different integrins, mew and if, are required on opposite wing epithelia. An early integrin-dependent process, not obviously required for prepupal adhesion, is essential to permit subsequent wing morphogenesis.
      if and mys can be localised by an intracellular mechanism within the muscles. Direct localisation of the transmembrane protein to sites of integrin function occurs in cells that lack endogenous mys and if or cells that lack extracellular signals from the tendon cells.
      Either splice form of if is sufficient for viability, but they do have distinct requirements during development. if function can replace mew function in the retina.
      Phenotypic analysis of mew, if and mys embryos suggests multiple roles for PS integrins in the adhesion of cells and in the formation, organization and migration of embryonic tissues. Although the proteins are often expressed in adjacent embryonic tissues, this distribution does not necessarily reflect equivalent requirements. The complete loss of both α subunits, encoded by mew and if, does not produce all the phenotypes observed in embryos lacking the mys encoded β subunit.
      Molecular and genetic analysis prove that the αPS2 integrin subunit is encoded by the if locus. Comparison of the null phenotypes of mys (encoding the ΒPS integrin subunit) and if rules out a model where PS integrin function occurs solely by the direct interaction of the two PS integrins, αPS1ΒPS and αPS2ΒPS.
      if has been expressed on the surface of Drosophila tissue culture cells. if gene product promotes cell spreading on two different extra cellular matrix (ECM) molecules, laminin and tiggin.
      Muscle phenotype of mutants studied using polarised light microscopy and antibody staining to detect Mhc-lacZ reporter gene expression in muscles.
      The distribution of mew, if and scb proteins in cultured cell lines has been investigated.
      Scaffold attachment regions in the region surrounding if have been mapped.
      if gene product is the PS2α integrin subunit. if is required to ensure the correct apposition and patterning of the wing epithelia.
      Structural gene for the α-subunit of position specific integrin 2 (PS2), a large transmembrane protein (Bogaert, Brown and Wilcox, 1987). The β-subunit can associate with either of the two α-subunits, PS1 or PS2 (Brower et al., 1984; Wilcox et al., 1984). Both α and β integrin are expressed in embryonic and larval tissues. In early development, PS2 is found in the mesoderm, localized to muscle attachments (Bogaert, Brown and Wilcox, 1987). Later, PS1 is expressed in the presumptive dorsal epithelium of the third instar imaginal wing discs; also, PS2 is found in the ventral epithelium, both integrins being important for the joining of the dorsal and ventral surfaces of the wing blade (Brower and Jaffe, 1989). Null mutations cause embryonic lethality (Wilcox, DiAntonio and Leptin, 1989). In the mutant if1, the adult wing is inflated with lymph and smaller than normal; venation is defective. Wings later become dry and blistered.
      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 78 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      Other crossreferences
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyMine - An integrated database for Drosophila genomics
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Synonyms and Secondary IDs (38)
      Reported As
      Symbol Synonym
      if
      (Xu et al., 2019, Camuglia et al., 2018, Lee et al., 2018, Park et al., 2018, Richier et al., 2018, Pérez-Moreno et al., 2017, Gene Disruption Project members, 2016-, Peters and Berg, 2016, Sandler and Stathopoulos, 2016, Maartens and Brown, 2015, Morozova et al., 2015, Ashwal-Fluss et al., 2014, DeSalvo et al., 2014, Kim and Choe, 2014, Kim et al., 2014, Meyer et al., 2014, Montgomery et al., 2014, Rembold et al., 2014, Weitkunat and Schnorrer, 2014, Brown et al., 2013.2.5, Ismat et al., 2013, Johnson et al., 2013, Lin et al., 2013, Liu et al., 2013, Nonaka et al., 2013, Pirraglia et al., 2013, Thimgan et al., 2013, Gates, 2012, Han et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Kim et al., 2012, Kókai et al., 2012, Ribeiro et al., 2011, Zervas et al., 2011, Cook et al., 2010, Fraichard et al., 2010, Gilsohn and Volk, 2010, Negreiros et al., 2010, Perkins et al., 2010, Popodi et al., 2010-, Tikhmyanova et al., 2010, Venken et al., 2010, Zhang et al., 2010, Christensen et al., 2009.2.28, Delon and Brown, 2009, Jattani et al., 2009, Liu et al., 2009, Chen et al., 2008, Christensen et al., 2008.9.3, Christensen et al., 2008.9.3, Christensen et al., 2008.9.3, Christensen et al., 2008.12.28, Dinkins et al., 2008, O'Reilly et al., 2008, Tsai et al., 2008, Zhang et al., 2008, Beltran et al., 2007, Chanana et al., 2007, Devenport et al., 2007, Dietzl et al., 2007, Estrada et al., 2007, Huang et al., 2007, Inoue and Hayashi, 2007, Junion et al., 2007, Ritzenthaler and Chiba, 2003)
      αPS2(ms8)
      αPS2
      (Camp et al., 2018, Park et al., 2018, Richier et al., 2018, Tang, 2017, Valdivia et al., 2017, Peters and Berg, 2016, Tavares et al., 2015, Wang et al., 2015, Dani et al., 2014, Xie et al., 2014, Ismat et al., 2013, Liu et al., 2013, Patel and Myat, 2013, Pirraglia et al., 2013, Bulgakova et al., 2012, Chountala et al., 2012, Gates, 2012, Han et al., 2012, Zhai et al., 2012, Egoz-Matia et al., 2011, Ellis et al., 2011, Pines et al., 2011, Urbano et al., 2011, Xie and Auld, 2011, Zervas et al., 2011, Fraichard et al., 2010, Delon and Brown, 2009, Jattani et al., 2009, Chen et al., 2008, Dinkins et al., 2008, Helsten et al., 2008, Loer et al., 2008, O'Reilly et al., 2008, Schotman et al., 2008, Devenport et al., 2007, Fernández-Miñán et al., 2007, Inoue and Hayashi, 2007, James et al., 2007, Jani and Schock, 2007, Nguyen et al., 2007, Takada et al., 2007, Tanentzapf et al., 2007, Lo, 2006, Tanentzapf and Brown, 2006, Tanentzapf et al., 2006, Bunch et al., 2004, Devenport and Brown, 2004, Grabbe et al., 2004, Abrams et al., 2003, Brower, 2003, Schock and Perrimon, 2003, Baker et al., 2002, Bokel and Brown, 2002, Jannuzi et al., 2002, Stevens and Jacobs, 2002, Bloor and Kiehart, 2001, Hughes, 2001, Zervas et al., 2001, Brown, 2000, Brown et al., 2000, D'Avino and Thummel, 2000, Hynes and Zhao, 2000, Kim and Chiba, 2000, Martin-Bermudo, 2000, Martin-Bermudo and Brown, 2000, Beumer et al., 1999, de Melker and Sonnenberg, 1999, Hoang and Chiba, 1998, Martin-Bermudo et al., 1998, Fleming et al., 1997, Martin-Bermudo et al., 1997, Prokop et al., 1996, Olson et al., 1995, Yarnitzky and Volk, 1995, Gotwals et al., 1994, Gotwals et al., 1994, Brown et al., 1993)
      αPS2 integrin
      Name Synonyms
      Integrin alphaPS2 subunit
      PS II alpha
      integrin PSI alpha subunit
      integrin αPS2 subunit
      position-specific antigen 2
      α2 integrin
      αPS2 integrin
      αPS2 Integrin
      αPS2-Integrin
      Secondary FlyBase IDs
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (345)