A Database of Drosophila Genes & Genomes

FB2013_03, released May 7th, 2013
 

Gene Dmel\if

General Information
SymbolDmel\ifSpeciesD. melanogaster
NameinflatedAnnotation symbolCG9623
Feature typeprotein_coding_geneFlyBase IDFBgn0001250
Gene Model StatusCurrent Stock availability 12 publicly available
Also Known AsαPS2, αPS2, PS2, PS2α, PSα2, aPS2, PS 2, αPS2C, α2Int
Genomic Location
Chromosome (arm)XRecombination map1-55
Cytogenetic map15A5-15A7Sequence locationX:16,646,222..16,677,467 [-]

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Automatically generated summary

See sections below for more information
The gene inflated is referred to in FlyBase by the symbol Dmel\if (CG9623, FBgn0001250). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: cell adhesion molecule binding; receptor activity. There is experimental evidence for 11 unique biological process terms, many of which group under: single-organism developmental process; cellular component organization or biogenesis; biological regulation; system development; neuron differentiation; post-embryonic organ morphogenesis; system process; gland morphogenesis; open tracheal system development; muscle cell differentiation; multicellular organismal development; salivary gland morphogenesis; localization; regulation of developmental process; sensory perception of chemical stimulus; cellular process; neuron projection development. 85 alleles are reported. The phenotypes of these alleles are annotated with: organ system; hypodermal muscle of larval abdomen; ISN innervated muscle of A1-7; organ system subdivision; non-connected developing system; adult segment; portion of tissue; extended germ band embryo; abdominal 7 longitudinal muscle; embryonic foregut; endoderm derivative. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: FG-GAP repeat; Integrin alpha beta-propellor; Integrin alpha chain; Integrin alpha chain, C-terminal cytoplasmic region, conserved site; Integrin alpha-2. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 12-24 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult crop, larval/adult hindgut, larval Malpighian tubules, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1632744_a_at completely aligns to an exonic region common to each of the 4 FlyBase-annotated transcript isoforms of if. Gene sequence location is X:16646222..16677467.

User Contributed Data
hide Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage
if: inflated
Structural gene for the α-subunit of position specific integrin 2 (PS2), a large transmembrane protein (Bogaert et al., 1987). The β-subunit can associate with either of the two α-subunits, PS1 or PS2 (Brower et al., 1984; Wilcox, Brown, Piovant, Smith, and White, 1984, EMBO J. 3: 2307-13). Both α and β integrin are expressed in embryonic and larval tissues. In early development, PS2 is found in the mesoderm, localized to muscle attachments (Bogaert et al., 1987). Later, PS1 is expressed in the presumptive dorsal epithelium of the third instar imaginal wing discs; also, PS2 is found in the ventral epithelium, both integrins being important for the joining of the dorsal and ventral surfaces of the wing blade (Brower and Jaffe, 1989). Null mutations cause embryonic lethality (Wilcox, DiAntonio, and Leptin). In the mutant if1, the adult wing is inflated with lymph and smaller than normal; venation is defective. Wings later become dry and blistered.
if3
Longitudinal veins thickened, especially at wing base. Anterior crossvein thickened. if3/if3 flies show reduced levels of PS2 integrin on the surfaces of some imaginal disc cells (especially in the ventral region), but levels of this integrin in muscle, salivary glands, and most other tissues seem to be normal (Brower and Jaffe, 1989). Adult wings typically show large round wing blisters, but the penetrance of this phenotype in homo- and hemizygotes is variable. if3/ifk27e flies show an increase in penetrance (from 15-20% in homozygotes to 60-70% in the heteroalleles); penetrance is reduced in if3/ifk27e flies by low temperature and crowding (Brower and Jaffe, 1989).
ifN
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Description
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This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
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FB2013_03
Controlled Vocabulary Terms
FB2013_02
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
15A5-15A7  
Limits computationally determined from genome sequence between P{EP}EP1547EP1547 and P{EP}CG4928EP1341  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
15A1-15A5  
(determined by in situ hybridisation)  
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
hide Gene Model & Products
Please see the GBrowse view of Dmel\if for information on other features GBrowse View Help
To submit a correction to a gene model please use the Contact FlyBase form
detailed view FBtr0074359 FBtr0301354 FBtr0301353 FBtr0074357 FBtr0301352 FBtr0074330 FBtr0074356 FBpp0074131 FBpp0290566 FBpp0290567 FBpp0290568 FBpp0074104 FBti0025212 FBti0071475 FBti0128216 FBti0143597 FBti0039040 FBti0024258 FBti0065525 FBti0066323
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
FBtr0074357
  5724
  1396
FBtr0301352
  5649
  1371
FBtr0301353
  5633
  1396
FBtr0301354
  5818
  1396
Additional Transcript Data & Comments
Reported size (kB)
5.7 (northern blot)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
if-PB  
FBpp0074131  
154.3  
1396  
6.10  
if-PC  
FBpp0290566  
151.6  
1371  
6.04  
if-PD  
FBpp0290567  
154.3  
1396  
6.10  
if-PF  
FBpp0290568  
154.3  
1396  
6.10  
Additional Polypeptide Data & Comments
Reported size (kDa)
1394 (aa); 140 (kD observed)
Comments
External Data
Linkouts
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
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Mapped Features have been reorganized, please see this article for details.
Additional mapped features and mutations can be found on GBrowse or related reports.
Type
Symbol & Location
Additional Notes
References
regulatory region
hide External Data
Linkouts
Crossreferences
hide Expression Data
hideTranscript Expression
radioisotope in situ
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
if transcripts are expressed throughout development and in adults. In embryos, they are first detected at stage 4 in the presumptive mesoderm. They continue to be expressed in mesodermal cells after invagination. In third instar larval wing discs, if transcripts are primarily restricted to the ventral compartment and to the peripodial membrane.
Marker for
Subcellular Localization
CV Term
hide Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
if protein is first detected in stage 10 embryos in the mesoderm where it is basally concentrated in cuboidal cells which lie on the ectoderm. After the somatic and visceral mesoderm separates, if protein is found on the basal cell surfaces of the visceral myoblasts when they attach to the foregut, midgut, and hindgut. It is also found at the sites of attachment of the somatic muscles. Protein was also detected in the gonadal sheath and in the interstitial cells of the gonad In third instar larval wing discs, if protein is primarily restricted to the ventral compartment.
Marker for
Subcellular Localization (GO Cellular Component)
CV term
References
inferred from direct assay
inferred from direct assay
hide Expression Deduced from Reporters
hide High-Throughput Expression Data
Associated Tools
Reference
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
hide FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)


   Styles
   Scales

Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult crop, larval/adult hindgut, larval Malpighian tubules, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult carcass.
[download data (TSV)]

Guide to FlyAtlas expression level colors
 
No expression (0 - 9.999)
 
Low expression (10 - 99.999)
 
Moderate expression (100 - 499.999)
 
High level expression (500 - 999.999)
 
Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue   Expression Level
Larval Central Nervous System
 
 145.2
Larval Midgut
 
 85.8
Larval Hindgut
 
 554.4
Larval Malpighian Tubules
 
 1185.7
Larval Fat Body
 
 23.4
Larval Salivary Gland
 
 493.2
Larval Trachea
 
 349.45
Larval Carcass
 
 991.75
Adult Head
 
 204.7
Adult Eye
 
 68.375
Adult Brain
 
 78.5
Adult Thoracic-Abdominal Ganglion
 
 117.7
Adult Crop
 
 925.1
Adult Midgut
 
 87.8
Adult Hindgut
 
 579.7
Adult Malpighian Tubules
 
 300.7
Adult Fat Body
 
 160.3
Adult Salivary Gland
 
 183.6
Adult Heart
 
 255.675
Adult VirginFemale Spermatheca
 
 234.7
Adult InseminatedFemale Spermatheca
 
 193.6
Adult Ovary
 
 21.5
Adult Testis
 
 34.5
Adult Male Accessory Gland
 
 96.7
Adult Carcass
 
 280.3
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Linear, scaled to Moderate expression
Tissue   Expression Level
Larval Central Nervous System
 
 145.2
Larval Midgut
 
 85.8
Larval Hindgut
 (554.4)
Larval Malpighian Tubules
 (1185.7)
Larval Fat Body
 
 23.4
Larval Salivary Gland
 
 493.2
Larval Trachea
 
 349.45
Larval Carcass
 (991.75)
Adult Head
 
 204.7
Adult Eye
 
 68.375
Adult Brain
 
 78.5
Adult Thoracic-Abdominal Ganglion
 
 117.7
Adult Crop
 (925.1)
Adult Midgut
 
 87.8
Adult Hindgut
 (579.7)
Adult Malpighian Tubules
 
 300.7
Adult Fat Body
 
 160.3
Adult Salivary Gland
 
 183.6
Adult Heart
 
 255.675
Adult VirginFemale Spermatheca
 
 234.7
Adult InseminatedFemale Spermatheca
 
 193.6
Adult Ovary
 
 21.5
Adult Testis
 
 34.5
Adult Male Accessory Gland
 
 96.7
Adult Carcass
 
 280.3
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
Linear, scaled to High level expression
Tissue   Expression Level
Larval Central Nervous System
 
 145.2
Larval Midgut
 
 85.8
Larval Hindgut
 
 554.4
Larval Malpighian Tubules
 (1185.7)
Larval Fat Body
 
 23.4
Larval Salivary Gland
 
 493.2
Larval Trachea
 
 349.45
Larval Carcass
 
 991.75
Adult Head
 
 204.7
Adult Eye
 
 68.375
Adult Brain
 
 78.5
Adult Thoracic-Abdominal Ganglion
 
 117.7
Adult Crop
 
 925.1
Adult Midgut
 
 87.8
Adult Hindgut
 
 579.7
Adult Malpighian Tubules
 
 300.7
Adult Fat Body
 
 160.3
Adult Salivary Gland
 
 183.6
Adult Heart
 
 255.675
Adult VirginFemale Spermatheca
 
 234.7
Adult InseminatedFemale Spermatheca
 
 193.6
Adult Ovary
 
 21.5
Adult Testis
 
 34.5
Adult Male Accessory Gland
 
 96.7
Adult Carcass
 
 280.3
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Linear, scaled to Very high expression
Tissue   Expression Level
Larval Central Nervous System
 
 145.2
Larval Midgut
 
 85.8
Larval Hindgut
 
 554.4
Larval Malpighian Tubules
 
 1185.7
Larval Fat Body
 
 23.4
Larval Salivary Gland
 
 493.2
Larval Trachea
 
 349.45
Larval Carcass
 
 991.75
Adult Head
 
 204.7
Adult Eye
 
 68.375
Adult Brain
 
 78.5
Adult Thoracic-Abdominal Ganglion
 
 117.7
Adult Crop
 
 925.1
Adult Midgut
 
 87.8
Adult Hindgut
 
 579.7
Adult Malpighian Tubules
 
 300.7
Adult Fat Body
 
 160.3
Adult Salivary Gland
 
 183.6
Adult Heart
 
 255.675
Adult VirginFemale Spermatheca
 
 234.7
Adult InseminatedFemale Spermatheca
 
 193.6
Adult Ovary
 
 21.5
Adult Testis
 
 34.5
Adult Male Accessory Gland
 
 96.7
Adult Carcass
 
 280.3
Expression Level Scale
 Very high 
log, scaled to maximum expression level
Tissue   Expression Level
Larval Central Nervous System
 
 145.2
Larval Midgut
 
 85.8
Larval Hindgut
 
 554.4
Larval Malpighian Tubules
 
 1185.7
Larval Fat Body
 
 23.4
Larval Salivary Gland
 
 493.2
Larval Trachea
 
 349.45
Larval Carcass
 
 991.75
Adult Head
 
 204.7
Adult Eye
 
 68.375
Adult Brain
 
 78.5
Adult Thoracic-Abdominal Ganglion
 
 117.7
Adult Crop
 
 925.1
Adult Midgut
 
 87.8
Adult Hindgut
 
 579.7
Adult Malpighian Tubules
 
 300.7
Adult Fat Body
 
 160.3
Adult Salivary Gland
 
 183.6
Adult Heart
 
 255.675
Adult VirginFemale Spermatheca
 
 234.7
Adult InseminatedFemale Spermatheca
 
 193.6
Adult Ovary
 
 21.5
Adult Testis
 
 34.5
Adult Male Accessory Gland
 
 96.7
Adult Carcass
 
 280.3
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to Moderate expression
Tissue   Expression Level
Larval Central Nervous System
 
 145.2
Larval Midgut
 
 85.8
Larval Hindgut
 554.4
Larval Malpighian Tubules
 (1185.7)
Larval Fat Body
 
 23.4
Larval Salivary Gland
 
 493.2
Larval Trachea
 
 349.45
Larval Carcass
 (991.75)
Adult Head
 
 204.7
Adult Eye
 
 68.375
Adult Brain
 
 78.5
Adult Thoracic-Abdominal Ganglion
 
 117.7
Adult Crop
 (925.1)
Adult Midgut
 
 87.8
Adult Hindgut
 579.7
Adult Malpighian Tubules
 
 300.7
Adult Fat Body
 
 160.3
Adult Salivary Gland
 
 183.6
Adult Heart
 
 255.675
Adult VirginFemale Spermatheca
 
 234.7
Adult InseminatedFemale Spermatheca
 
 193.6
Adult Ovary
 
 21.5
Adult Testis
 
 34.5
Adult Male Accessory Gland
 
 96.7
Adult Carcass
 
 280.3
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
log, scaled to High level expression
Tissue   Expression Level
Larval Central Nervous System
 
 145.2
Larval Midgut
 
 85.8
Larval Hindgut
 
 554.4
Larval Malpighian Tubules
 1185.7
Larval Fat Body
 
 23.4
Larval Salivary Gland
 
 493.2
Larval Trachea
 
 349.45
Larval Carcass
 
 991.75
Adult Head
 
 204.7
Adult Eye
 
 68.375
Adult Brain
 
 78.5
Adult Thoracic-Abdominal Ganglion
 
 117.7
Adult Crop
 
 925.1
Adult Midgut
 
 87.8
Adult Hindgut
 
 579.7
Adult Malpighian Tubules
 
 300.7
Adult Fat Body
 
 160.3
Adult Salivary Gland
 
 183.6
Adult Heart
 
 255.675
Adult VirginFemale Spermatheca
 
 234.7
Adult InseminatedFemale Spermatheca
 
 193.6
Adult Ovary
 
 21.5
Adult Testis
 
 34.5
Adult Male Accessory Gland
 
 96.7
Adult Carcass
 
 280.3
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to Very high expression
Tissue   Expression Level
Larval Central Nervous System
 
 145.2
Larval Midgut
 
 85.8
Larval Hindgut
 
 554.4
Larval Malpighian Tubules
 
 1185.7
Larval Fat Body
 
 23.4
Larval Salivary Gland
 
 493.2
Larval Trachea
 
 349.45
Larval Carcass
 
 991.75
Adult Head
 
 204.7
Adult Eye
 
 68.375
Adult Brain
 
 78.5
Adult Thoracic-Abdominal Ganglion
 
 117.7
Adult Crop
 
 925.1
Adult Midgut
 
 87.8
Adult Hindgut
 
 579.7
Adult Malpighian Tubules
 
 300.7
Adult Fat Body
 
 160.3
Adult Salivary Gland
 
 183.6
Adult Heart
 
 255.675
Adult VirginFemale Spermatheca
 
 234.7
Adult InseminatedFemale Spermatheca
 
 193.6
Adult Ovary
 
 21.5
Adult Testis
 
 34.5
Adult Male Accessory Gland
 
 96.7
Adult Carcass
 
 280.3
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Heatmap
Tissue   Expression Level
Larval Central Nervous System
 
 
Larval Midgut
 
 
Larval Hindgut
 
 
Larval Malpighian Tubules
 
 
Larval Fat Body
 
 
Larval Salivary Gland
 
 
Larval Trachea
 
 
Larval Carcass
 
 
Adult Head
 
 
Adult Eye
 
 
Adult Brain
 
 
Adult Thoracic-Abdominal Ganglion
 
 
Adult Crop
 
 
Adult Midgut
 
 
Adult Hindgut
 
 
Adult Malpighian Tubules
 
 
Adult Fat Body
 
 
Adult Salivary Gland
 
 
Adult Heart
 
 
Adult VirginFemale Spermatheca
 
 
Adult InseminatedFemale Spermatheca
 
 
Adult Ovary
 
 
Adult Testis
 
 
Adult Male Accessory Gland
 
 
Adult Carcass
 
 

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level Tissue Adult Expression Level
 
NA 
Head
 
 204.7
 
NA 
Eye
 
 68.375
 
NA 
Brain
 
 78.5
 
145.2 
Central Nervous System
 
 NA
 
NA 
Thoracic-Abdominal Ganglion
 
 117.7
 
NA 
Crop
 
 925.1
 
85.8 
Midgut
 
 87.8
 
554.4 
Hindgut
 
 579.7
 
1185.7 
Malpighian Tubules
 
 300.7
 
no informative data 
Fat Body
 
 160.3
 
493.2 
Salivary Gland
 
 183.6
 
NA 
Heart
 
 255.675
 
349.45 
Trachea
 
 NA
 
NA 
VirginFemale Spermatheca
 
 234.7
 
NA 
InseminatedFemale Spermatheca
 
 193.6
 
NA 
Ovary
 
 21.5
 
NA 
Testis
 
 34.5
 
NA 
Male Accessory Gland
 
 96.7
 
991.75 
Carcass
 
 280.3

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
hide modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)


   Styles
   Scales


[download data (TSV)]

Guide to modENCODE expression level colors
 
No/Extremely low expression (0 - 0)
 
Very low expression (1 - 3)
 
Low expression (4 - 10)
 
Moderate expression (11 - 25)
 
Moderately high expression (26 - 50)
 
High expression (51 - 100)
 
Very high expression (101 - 1000)
 
Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 7
central nervous system, larvae L3
 
 5
central nervous system, pupae P8
 
 5
head, virgin 1-day female
 
 14
head, virgin 4-day female
 
 9
head, virgin 20-day female
 
 11
head, mated 1-day female
 
 10
head, mated 4-day female
 
 9
head, mated 20-day female
 
 8
head, mated 1-day male
 
 15
head, mated 4-day male
 
 12
head, mated 20-day male
 
 14
salivary gland, larvae L3 wandering
 
 1
salivary gland, white prepupae
 
 1
digestive system, larvae L3 wandering
 
 4
digestive system, 1-day adult
 
 6
digestive system, 4-day adult
 
 6
digestive system, 20-day adult
 
 5
fat body, larvae L3 wandering
 
 3
fat body, white prepupae
 
 2
fat body, pupae P8
 
 4
carcass, larvae L3 wandering
 
 14
carcass, 1-day adult
 
 22
carcass, 4-day adult
 
 17
carcass, 20-day adult
 
 15
ovary, virgin 4-day female
 
 1
ovary, mated 4-day female
 
 1
testis, mated 4-day male
 
 1
accessory gland, mated 4-day male
 
 2
Expression Level Scale
 Very low 
 Low 
 Moderate 
Linear, scaled to Moderate expression
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 7
central nervous system, larvae L3
 
 5
central nervous system, pupae P8
 
 5
head, virgin 1-day female
 
 14
head, virgin 4-day female
 
 9
head, virgin 20-day female
 
 11
head, mated 1-day female
 
 10
head, mated 4-day female
 
 9
head, mated 20-day female
 
 8
head, mated 1-day male
 
 15
head, mated 4-day male
 
 12
head, mated 20-day male
 
 14
salivary gland, larvae L3 wandering
 
 1
salivary gland, white prepupae
 
 1
digestive system, larvae L3 wandering
 
 4
digestive system, 1-day adult
 
 6
digestive system, 4-day adult
 
 6
digestive system, 20-day adult
 
 5
fat body, larvae L3 wandering
 
 3
fat body, white prepupae
 
 2
fat body, pupae P8
 
 4
carcass, larvae L3 wandering
 
 14
carcass, 1-day adult
 
 22
carcass, 4-day adult
 
 17
carcass, 20-day adult
 
 15
ovary, virgin 4-day female
 
 1
ovary, mated 4-day female
 
 1
testis, mated 4-day male
 
 1
accessory gland, mated 4-day male
 
 2
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 7
central nervous system, larvae L3
 
 5
central nervous system, pupae P8
 
 5
head, virgin 1-day female
 
 14
head, virgin 4-day female
 
 9
head, virgin 20-day female
 
 11
head, mated 1-day female
 
 10
head, mated 4-day female
 
 9
head, mated 20-day female
 
 8
head, mated 1-day male
 
 15
head, mated 4-day male
 
 12
head, mated 20-day male
 
 14
salivary gland, larvae L3 wandering
 
 1
salivary gland, white prepupae
 
 1
digestive system, larvae L3 wandering
 
 4
digestive system, 1-day adult
 
 6
digestive system, 4-day adult
 
 6
digestive system, 20-day adult
 
 5
fat body, larvae L3 wandering
 
 3
fat body, white prepupae
 
 2
fat body, pupae P8
 
 4
carcass, larvae L3 wandering
 
 14
carcass, 1-day adult
 
 22
carcass, 4-day adult
 
 17
carcass, 20-day adult
 
 15
ovary, virgin 4-day female
 
 1
ovary, mated 4-day female
 
 1
testis, mated 4-day male
 
 1
accessory gland, mated 4-day male
 
 2
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 7
central nervous system, larvae L3
 
 5
central nervous system, pupae P8
 
 5
head, virgin 1-day female
 
 14
head, virgin 4-day female
 
 9
head, virgin 20-day female
 
 11
head, mated 1-day female
 
 10
head, mated 4-day female
 
 9
head, mated 20-day female
 
 8
head, mated 1-day male
 
 15
head, mated 4-day male
 
 12
head, mated 20-day male
 
 14
salivary gland, larvae L3 wandering
 
 1
salivary gland, white prepupae
 
 1
digestive system, larvae L3 wandering
 
 4
digestive system, 1-day adult
 
 6
digestive system, 4-day adult
 
 6
digestive system, 20-day adult
 
 5
fat body, larvae L3 wandering
 
 3
fat body, white prepupae
 
 2
fat body, pupae P8
 
 4
carcass, larvae L3 wandering
 
 14
carcass, 1-day adult
 
 22
carcass, 4-day adult
 
 17
carcass, 20-day adult
 
 15
ovary, virgin 4-day female
 
 1
ovary, mated 4-day female
 
 1
testis, mated 4-day male
 
 1
accessory gland, mated 4-day male
 
 2
Expression Level Scale
 Extremely high 
log, scaled to maximum expression level
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 7
central nervous system, larvae L3
 
 5
central nervous system, pupae P8
 
 5
head, virgin 1-day female
 
 14
head, virgin 4-day female
 
 9
head, virgin 20-day female
 
 11
head, mated 1-day female
 
 10
head, mated 4-day female
 
 9
head, mated 20-day female
 
 8
head, mated 1-day male
 
 15
head, mated 4-day male
 
 12
head, mated 20-day male
 
 14
salivary gland, larvae L3 wandering
 
 1
salivary gland, white prepupae
 
 1
digestive system, larvae L3 wandering
 
 4
digestive system, 1-day adult
 
 6
digestive system, 4-day adult
 
 6
digestive system, 20-day adult
 
 5
fat body, larvae L3 wandering
 
 3
fat body, white prepupae
 
 2
fat body, pupae P8
 
 4
carcass, larvae L3 wandering
 
 14
carcass, 1-day adult
 
 22
carcass, 4-day adult
 
 17
carcass, 20-day adult
 
 15
ovary, virgin 4-day female
 
 1
ovary, mated 4-day female
 
 1
testis, mated 4-day male
 
 1
accessory gland, mated 4-day male
 
 2
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to Moderate expression
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 7
central nervous system, larvae L3
 
 5
central nervous system, pupae P8
 
 5
head, virgin 1-day female
 
 14
head, virgin 4-day female
 
 9
head, virgin 20-day female
 
 11
head, mated 1-day female
 
 10
head, mated 4-day female
 
 9
head, mated 20-day female
 
 8
head, mated 1-day male
 
 15
head, mated 4-day male
 
 12
head, mated 20-day male
 
 14
salivary gland, larvae L3 wandering
 
 1
salivary gland, white prepupae
 
 1
digestive system, larvae L3 wandering
 
 4
digestive system, 1-day adult
 
 6
digestive system, 4-day adult
 
 6
digestive system, 20-day adult
 
 5
fat body, larvae L3 wandering
 
 3
fat body, white prepupae
 
 2
fat body, pupae P8
 
 4
carcass, larvae L3 wandering
 
 14
carcass, 1-day adult
 
 22
carcass, 4-day adult
 
 17
carcass, 20-day adult
 
 15
ovary, virgin 4-day female
 
 1
ovary, mated 4-day female
 
 1
testis, mated 4-day male
 
 1
accessory gland, mated 4-day male
 
 2
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 7
central nervous system, larvae L3
 
 5
central nervous system, pupae P8
 
 5
head, virgin 1-day female
 
 14
head, virgin 4-day female
 
 9
head, virgin 20-day female
 
 11
head, mated 1-day female
 
 10
head, mated 4-day female
 
 9
head, mated 20-day female
 
 8
head, mated 1-day male
 
 15
head, mated 4-day male
 
 12
head, mated 20-day male
 
 14
salivary gland, larvae L3 wandering
 
 1
salivary gland, white prepupae
 
 1
digestive system, larvae L3 wandering
 
 4
digestive system, 1-day adult
 
 6
digestive system, 4-day adult
 
 6
digestive system, 20-day adult
 
 5
fat body, larvae L3 wandering
 
 3
fat body, white prepupae
 
 2
fat body, pupae P8
 
 4
carcass, larvae L3 wandering
 
 14
carcass, 1-day adult
 
 22
carcass, 4-day adult
 
 17
carcass, 20-day adult
 
 15
ovary, virgin 4-day female
 
 1
ovary, mated 4-day female
 
 1
testis, mated 4-day male
 
 1
accessory gland, mated 4-day male
 
 2
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 7
central nervous system, larvae L3
 
 5
central nervous system, pupae P8
 
 5
head, virgin 1-day female
 
 14
head, virgin 4-day female
 
 9
head, virgin 20-day female
 
 11
head, mated 1-day female
 
 10
head, mated 4-day female
 
 9
head, mated 20-day female
 
 8
head, mated 1-day male
 
 15
head, mated 4-day male
 
 12
head, mated 20-day male
 
 14
salivary gland, larvae L3 wandering
 
 1
salivary gland, white prepupae
 
 1
digestive system, larvae L3 wandering
 
 4
digestive system, 1-day adult
 
 6
digestive system, 4-day adult
 
 6
digestive system, 20-day adult
 
 5
fat body, larvae L3 wandering
 
 3
fat body, white prepupae
 
 2
fat body, pupae P8
 
 4
carcass, larvae L3 wandering
 
 14
carcass, 1-day adult
 
 22
carcass, 4-day adult
 
 17
carcass, 20-day adult
 
 15
ovary, virgin 4-day female
 
 1
ovary, mated 4-day female
 
 1
testis, mated 4-day male
 
 1
accessory gland, mated 4-day male
 
 2
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Tissue   Expression Level
imaginal disc, larvae L3 wandering
 
 
central nervous system, larvae L3
 
 
central nervous system, pupae P8
 
 
head, virgin 1-day female
 
 
head, virgin 4-day female
 
 
head, virgin 20-day female
 
 
head, mated 1-day female
 
 
head, mated 4-day female
 
 
head, mated 20-day female
 
 
head, mated 1-day male
 
 
head, mated 4-day male
 
 
head, mated 20-day male
 
 
salivary gland, larvae L3 wandering
 
 
salivary gland, white prepupae
 
 
digestive system, larvae L3 wandering
 
 
digestive system, 1-day adult
 
 
digestive system, 4-day adult
 
 
digestive system, 20-day adult
 
 
fat body, larvae L3 wandering
 
 
fat body, white prepupae
 
 
fat body, pupae P8
 
 
carcass, larvae L3 wandering
 
 
carcass, 1-day adult
 
 
carcass, 4-day adult
 
 
carcass, 20-day adult
 
 
ovary, virgin 4-day female
 
 
ovary, mated 4-day female
 
 
testis, mated 4-day male
 
 
accessory gland, mated 4-day male
 
 

hide modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)


   Styles
   Scales

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 12-24 hour embryonic stages.
[download data (TSV)]

Guide to modENCODE expression level colors
 
No/Extremely low expression (0 - 0)
 
Very low expression (1 - 3)
 
Low expression (4 - 10)
 
Moderate expression (11 - 25)
 
Moderately high expression (26 - 50)
 
High expression (51 - 100)
 
Very high expression (101 - 1000)
 
Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 1
embryo 02-04hr
 
 6
embryo 04-06hr
 
 12
embryo 06-08hr
 
 13
embryo 08-10hr
 
 12
embryo 10-12hr
 
 18
embryo 12-14hr
 
 25
embryo 14-16hr
 
 46
embryo 16-18hr
 
 71
embryo 18-20hr
 
 118
embryo 20-22hr
 
 63
embryo 22-24hr
 
 61
larva L1
 
 29
larva L2
 
 23
larva L3 12hr old
 
 33
larva L3 puffstage 1-2
 
 15
larva L3 puffstage 3-6
 
 19
larva L3 puffstage 7-9
 
 16
white prepupae new
 
 13
white prepupae 12hr
 
 14
white prepupae 24hr
 
 13
pupae 2d postWPP
 
 17
pupae 3d postWPP
 
 50
pupae 4d postWPP
 
 36
adult male 01day
 
 28
adult male 05day
 
 24
adult male 30day
 
 22
adult female 01day
 
 17
adult female 05day
 
 6
adult female 30day
 
 7
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 1
embryo 02-04hr
 
 6
embryo 04-06hr
 
 12
embryo 06-08hr
 
 13
embryo 08-10hr
 
 12
embryo 10-12hr
 
 18
embryo 12-14hr
 
 25
embryo 14-16hr
 (46)
embryo 16-18hr
 (71)
embryo 18-20hr
 (118)
embryo 20-22hr
 (63)
embryo 22-24hr
 (61)
larva L1
 (29)
larva L2
 
 23
larva L3 12hr old
 (33)
larva L3 puffstage 1-2
 
 15
larva L3 puffstage 3-6
 
 19
larva L3 puffstage 7-9
 
 16
white prepupae new
 
 13
white prepupae 12hr
 
 14
white prepupae 24hr
 
 13
pupae 2d postWPP
 
 17
pupae 3d postWPP
 (50)
pupae 4d postWPP
 (36)
adult male 01day
 (28)
adult male 05day
 
 24
adult male 30day
 
 22
adult female 01day
 
 17
adult female 05day
 
 6
adult female 30day
 
 7
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 1
embryo 02-04hr
 
 6
embryo 04-06hr
 
 12
embryo 06-08hr
 
 13
embryo 08-10hr
 
 12
embryo 10-12hr
 
 18
embryo 12-14hr
 
 25
embryo 14-16hr
 
 46
embryo 16-18hr
 
 71
embryo 18-20hr
 (118)
embryo 20-22hr
 
 63
embryo 22-24hr
 
 61
larva L1
 
 29
larva L2
 
 23
larva L3 12hr old
 
 33
larva L3 puffstage 1-2
 
 15
larva L3 puffstage 3-6
 
 19
larva L3 puffstage 7-9
 
 16
white prepupae new
 
 13
white prepupae 12hr
 
 14
white prepupae 24hr
 
 13
pupae 2d postWPP
 
 17
pupae 3d postWPP
 
 50
pupae 4d postWPP
 
 36
adult male 01day
 
 28
adult male 05day
 
 24
adult male 30day
 
 22
adult female 01day
 
 17
adult female 05day
 
 6
adult female 30day
 
 7
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 1
embryo 02-04hr
 
 6
embryo 04-06hr
 
 12
embryo 06-08hr
 
 13
embryo 08-10hr
 
 12
embryo 10-12hr
 
 18
embryo 12-14hr
 
 25
embryo 14-16hr
 
 46
embryo 16-18hr
 
 71
embryo 18-20hr
 
 118
embryo 20-22hr
 
 63
embryo 22-24hr
 
 61
larva L1
 
 29
larva L2
 
 23
larva L3 12hr old
 
 33
larva L3 puffstage 1-2
 
 15
larva L3 puffstage 3-6
 
 19
larva L3 puffstage 7-9
 
 16
white prepupae new
 
 13
white prepupae 12hr
 
 14
white prepupae 24hr
 
 13
pupae 2d postWPP
 
 17
pupae 3d postWPP
 
 50
pupae 4d postWPP
 
 36
adult male 01day
 
 28
adult male 05day
 
 24
adult male 30day
 
 22
adult female 01day
 
 17
adult female 05day
 
 6
adult female 30day
 
 7
Expression Level Scale
 Extremely high 
log, scaled to maximum expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 1
embryo 02-04hr
 
 6
embryo 04-06hr
 
 12
embryo 06-08hr
 
 13
embryo 08-10hr
 
 12
embryo 10-12hr
 
 18
embryo 12-14hr
 
 25
embryo 14-16hr
 
 46
embryo 16-18hr
 
 71
embryo 18-20hr
 
 118
embryo 20-22hr
 
 63
embryo 22-24hr
 
 61
larva L1
 
 29
larva L2
 
 23
larva L3 12hr old
 
 33
larva L3 puffstage 1-2
 
 15
larva L3 puffstage 3-6
 
 19
larva L3 puffstage 7-9
 
 16
white prepupae new
 
 13
white prepupae 12hr
 
 14
white prepupae 24hr
 
 13
pupae 2d postWPP
 
 17
pupae 3d postWPP
 
 50
pupae 4d postWPP
 
 36
adult male 01day
 
 28
adult male 05day
 
 24
adult male 30day
 
 22
adult female 01day
 
 17
adult female 05day
 
 6
adult female 30day
 
 7
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 1
embryo 02-04hr
 
 6
embryo 04-06hr
 
 12
embryo 06-08hr
 
 13
embryo 08-10hr
 
 12
embryo 10-12hr
 
 18
embryo 12-14hr
 
 25
embryo 14-16hr
 (46)
embryo 16-18hr
 (71)
embryo 18-20hr
 (118)
embryo 20-22hr
 (63)
embryo 22-24hr
 (61)
larva L1
 29
larva L2
 
 23
larva L3 12hr old
 (33)
larva L3 puffstage 1-2
 
 15
larva L3 puffstage 3-6
 
 19
larva L3 puffstage 7-9
 
 16
white prepupae new
 
 13
white prepupae 12hr
 
 14
white prepupae 24hr
 
 13
pupae 2d postWPP
 
 17
pupae 3d postWPP
 (50)
pupae 4d postWPP
 (36)
adult male 01day
 28
adult male 05day
 
 24
adult male 30day
 
 22
adult female 01day
 
 17
adult female 05day
 
 6
adult female 30day
 
 7
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 1
embryo 02-04hr
 
 6
embryo 04-06hr
 
 12
embryo 06-08hr
 
 13
embryo 08-10hr
 
 12
embryo 10-12hr
 
 18
embryo 12-14hr
 
 25
embryo 14-16hr
 
 46
embryo 16-18hr
 
 71
embryo 18-20hr
 118
embryo 20-22hr
 
 63
embryo 22-24hr
 
 61
larva L1
 
 29
larva L2
 
 23
larva L3 12hr old
 
 33
larva L3 puffstage 1-2
 
 15
larva L3 puffstage 3-6
 
 19
larva L3 puffstage 7-9
 
 16
white prepupae new
 
 13
white prepupae 12hr
 
 14
white prepupae 24hr
 
 13
pupae 2d postWPP
 
 17
pupae 3d postWPP
 
 50
pupae 4d postWPP
 
 36
adult male 01day
 
 28
adult male 05day
 
 24
adult male 30day
 
 22
adult female 01day
 
 17
adult female 05day
 
 6
adult female 30day
 
 7
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 1
embryo 02-04hr
 
 6
embryo 04-06hr
 
 12
embryo 06-08hr
 
 13
embryo 08-10hr
 
 12
embryo 10-12hr
 
 18
embryo 12-14hr
 
 25
embryo 14-16hr
 
 46
embryo 16-18hr
 
 71
embryo 18-20hr
 
 118
embryo 20-22hr
 
 63
embryo 22-24hr
 
 61
larva L1
 
 29
larva L2
 
 23
larva L3 12hr old
 
 33
larva L3 puffstage 1-2
 
 15
larva L3 puffstage 3-6
 
 19
larva L3 puffstage 7-9
 
 16
white prepupae new
 
 13
white prepupae 12hr
 
 14
white prepupae 24hr
 
 13
pupae 2d postWPP
 
 17
pupae 3d postWPP
 
 50
pupae 4d postWPP
 
 36
adult male 01day
 
 28
adult male 05day
 
 24
adult male 30day
 
 22
adult female 01day
 
 17
adult female 05day
 
 6
adult female 30day
 
 7
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Developmental Stage   Expression Level
embryo 00-02hr
 
 
embryo 02-04hr
 
 
embryo 04-06hr
 
 
embryo 06-08hr
 
 
embryo 08-10hr
 
 
embryo 10-12hr
 
 
embryo 12-14hr
 
 
embryo 14-16hr
 
 
embryo 16-18hr
 
 
embryo 18-20hr
 
 
embryo 20-22hr
 
 
embryo 22-24hr
 
 
larva L1
 
 
larva L2
 
 
larva L3 12hr old
 
 
larva L3 puffstage 1-2
 
 
larva L3 puffstage 3-6
 
 
larva L3 puffstage 7-9
 
 
white prepupae new
 
 
white prepupae 12hr
 
 
white prepupae 24hr
 
 
pupae 2d postWPP
 
 
pupae 3d postWPP
 
 
pupae 4d postWPP
 
 
adult male 01day
 
 
adult male 05day
 
 
adult male 30day
 
 
adult female 01day
 
 
adult female 05day
 
 
adult female 30day
 
 

modENCODE Temporal Expression Data (Graveley et al., 2011)
hide modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)


   Styles
   Scales


[download data (TSV)]

Guide to modENCODE expression level colors
 
No/Extremely low expression (0 - 0)
 
Very low expression (1 - 3)
 
Low expression (4 - 10)
 
Moderate expression (11 - 25)
 
Moderately high expression (26 - 50)
 
High expression (51 - 100)
 
Very high expression (101 - 1000)
 
Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line   Expression Level
Schneider line 2 S2R+
 
 2
Schneider line 2 Sg4
 
 39
embryonic 1182-4H
 
 1
embryonic GM2
 
 0
embryonic Kc167
 
 0
embryonic S1
 
 0
embryonic S3
 
 41
leg disc CME L1
 
 30
wing disc CME-W2
 
 18
wing disc ML-DmD8
 
 7
wing disc ML-DmD9
 
 5
wing disc ML-DmD16-c3
 
 5
wing disc ML-DmD21
 
 9
wing disc ML-DmD32
 
 7
haltere disc ML-DmD17-c3
 
 8
eye-antennal disc ML-DmD11
 
 10
antennal disc ML-DmD20-c5
 
 1
mixed discs ML-DmD4-c1
 
 17
CNS ML-DmBG1-c1
 
 0
CNS ML-DmBG2-c2
 
 0
tumorous blood cells mbn2
 
 1
ovary fGS/OSS
 
 12
ovary OSC
 
 8
ovary OSS
 
 8
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to Moderate expression
Cell Line   Expression Level
Schneider line 2 S2R+
 
 2
Schneider line 2 Sg4
 (39)
embryonic 1182-4H
 
 1
embryonic GM2
 
 0
embryonic Kc167
 
 0
embryonic S1
 
 0
embryonic S3
 (41)
leg disc CME L1
 (30)
wing disc CME-W2
 
 18
wing disc ML-DmD8
 
 7
wing disc ML-DmD9
 
 5
wing disc ML-DmD16-c3
 
 5
wing disc ML-DmD21
 
 9
wing disc ML-DmD32
 
 7
haltere disc ML-DmD17-c3
 
 8
eye-antennal disc ML-DmD11
 
 10
antennal disc ML-DmD20-c5
 
 1
mixed discs ML-DmD4-c1
 
 17
CNS ML-DmBG1-c1
 
 0
CNS ML-DmBG2-c2
 
 0
tumorous blood cells mbn2
 
 1
ovary fGS/OSS
 
 12
ovary OSC
 
 8
ovary OSS
 
 8
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Cell Line   Expression Level
Schneider line 2 S2R+
 
 2
Schneider line 2 Sg4
 
 39
embryonic 1182-4H
 
 1
embryonic GM2
 
 0
embryonic Kc167
 
 0
embryonic S1
 
 0
embryonic S3
 
 41
leg disc CME L1
 
 30
wing disc CME-W2
 
 18
wing disc ML-DmD8
 
 7
wing disc ML-DmD9
 
 5
wing disc ML-DmD16-c3
 
 5
wing disc ML-DmD21
 
 9
wing disc ML-DmD32
 
 7
haltere disc ML-DmD17-c3
 
 8
eye-antennal disc ML-DmD11
 
 10
antennal disc ML-DmD20-c5
 
 1
mixed discs ML-DmD4-c1
 
 17
CNS ML-DmBG1-c1
 
 0
CNS ML-DmBG2-c2
 
 0
tumorous blood cells mbn2
 
 1
ovary fGS/OSS
 
 12
ovary OSC
 
 8
ovary OSS
 
 8
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Cell Line   Expression Level
Schneider line 2 S2R+
 
 2
Schneider line 2 Sg4
 
 39
embryonic 1182-4H
 
 1
embryonic GM2
 
 0
embryonic Kc167
 
 0
embryonic S1
 
 0
embryonic S3
 
 41
leg disc CME L1
 
 30
wing disc CME-W2
 
 18
wing disc ML-DmD8
 
 7
wing disc ML-DmD9
 
 5
wing disc ML-DmD16-c3
 
 5
wing disc ML-DmD21
 
 9
wing disc ML-DmD32
 
 7
haltere disc ML-DmD17-c3
 
 8
eye-antennal disc ML-DmD11
 
 10
antennal disc ML-DmD20-c5
 
 1
mixed discs ML-DmD4-c1
 
 17
CNS ML-DmBG1-c1
 
 0
CNS ML-DmBG2-c2
 
 0
tumorous blood cells mbn2
 
 1
ovary fGS/OSS
 
 12
ovary OSC
 
 8
ovary OSS
 
 8
Expression Level Scale
 Extremely high 
log, scaled to maximum expression level
Cell Line   Expression Level
Schneider line 2 S2R+
 
 2
Schneider line 2 Sg4
 
 39
embryonic 1182-4H
 
 1
embryonic GM2
 
 0
embryonic Kc167
 
 0
embryonic S1
 
 0
embryonic S3
 
 41
leg disc CME L1
 
 30
wing disc CME-W2
 
 18
wing disc ML-DmD8
 
 7
wing disc ML-DmD9
 
 5
wing disc ML-DmD16-c3
 
 5
wing disc ML-DmD21
 
 9
wing disc ML-DmD32
 
 7
haltere disc ML-DmD17-c3
 
 8
eye-antennal disc ML-DmD11
 
 10
antennal disc ML-DmD20-c5
 
 1
mixed discs ML-DmD4-c1
 
 17
CNS ML-DmBG1-c1
 
 0
CNS ML-DmBG2-c2
 
 0
tumorous blood cells mbn2
 
 1
ovary fGS/OSS
 
 12
ovary OSC
 
 8
ovary OSS
 
 8
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
log, scaled to Moderate expression
Cell Line   Expression Level
Schneider line 2 S2R+
 
 2
Schneider line 2 Sg4
 (39)
embryonic 1182-4H
 
 1
embryonic GM2
 
 0
embryonic Kc167
 
 0
embryonic S1
 
 0
embryonic S3
 (41)
leg disc CME L1
 30
wing disc CME-W2
 
 18
wing disc ML-DmD8
 
 7
wing disc ML-DmD9
 
 5
wing disc ML-DmD16-c3
 
 5
wing disc ML-DmD21
 
 9
wing disc ML-DmD32
 
 7
haltere disc ML-DmD17-c3
 
 8
eye-antennal disc ML-DmD11
 
 10
antennal disc ML-DmD20-c5
 
 1
mixed discs ML-DmD4-c1
 
 17
CNS ML-DmBG1-c1
 
 0
CNS ML-DmBG2-c2
 
 0
tumorous blood cells mbn2
 
 1
ovary fGS/OSS
 
 12
ovary OSC
 
 8
ovary OSS
 
 8
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Cell Line   Expression Level
Schneider line 2 S2R+
 
 2
Schneider line 2 Sg4
 
 39
embryonic 1182-4H
 
 1
embryonic GM2
 
 0
embryonic Kc167
 
 0
embryonic S1
 
 0
embryonic S3
 
 41
leg disc CME L1
 
 30
wing disc CME-W2
 
 18
wing disc ML-DmD8
 
 7
wing disc ML-DmD9
 
 5
wing disc ML-DmD16-c3
 
 5
wing disc ML-DmD21
 
 9
wing disc ML-DmD32
 
 7
haltere disc ML-DmD17-c3
 
 8
eye-antennal disc ML-DmD11
 
 10
antennal disc ML-DmD20-c5
 
 1
mixed discs ML-DmD4-c1
 
 17
CNS ML-DmBG1-c1
 
 0
CNS ML-DmBG2-c2
 
 0
tumorous blood cells mbn2
 
 1
ovary fGS/OSS
 
 12
ovary OSC
 
 8
ovary OSS
 
 8
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Cell Line   Expression Level
Schneider line 2 S2R+
 
 2
Schneider line 2 Sg4
 
 39
embryonic 1182-4H
 
 1
embryonic GM2
 
 0
embryonic Kc167
 
 0
embryonic S1
 
 0
embryonic S3
 
 41
leg disc CME L1
 
 30
wing disc CME-W2
 
 18
wing disc ML-DmD8
 
 7
wing disc ML-DmD9
 
 5
wing disc ML-DmD16-c3
 
 5
wing disc ML-DmD21
 
 9
wing disc ML-DmD32
 
 7
haltere disc ML-DmD17-c3
 
 8
eye-antennal disc ML-DmD11
 
 10
antennal disc ML-DmD20-c5
 
 1
mixed discs ML-DmD4-c1
 
 17
CNS ML-DmBG1-c1
 
 0
CNS ML-DmBG2-c2
 
 0
tumorous blood cells mbn2
 
 1
ovary fGS/OSS
 
 12
ovary OSC
 
 8
ovary OSS
 
 8
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Cell Line   Expression Level
Schneider line 2 S2R+
 
 
Schneider line 2 Sg4
 
 
embryonic 1182-4H
 
 
embryonic GM2
 
 
embryonic Kc167
 
 
embryonic S1
 
 
embryonic S3
 
 
leg disc CME L1
 
 
wing disc CME-W2
 
 
wing disc ML-DmD8
 
 
wing disc ML-DmD9
 
 
wing disc ML-DmD16-c3
 
 
wing disc ML-DmD21
 
 
wing disc ML-DmD32
 
 
haltere disc ML-DmD17-c3
 
 
eye-antennal disc ML-DmD11
 
 
antennal disc ML-DmD20-c5
 
 
mixed discs ML-DmD4-c1
 
 
CNS ML-DmBG1-c1
 
 
CNS ML-DmBG2-c2
 
 
tumorous blood cells mbn2
 
 
ovary fGS/OSS
 
 
ovary OSC
 
 
ovary OSS
 
 

hide modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)


   Styles
   Scales


[download data (TSV)]

Guide to modENCODE expression level colors
 
No/Extremely low expression (0 - 0)
 
Very low expression (1 - 3)
 
Low expression (4 - 10)
 
Moderate expression (11 - 25)
 
Moderately high expression (26 - 50)
 
High expression (51 - 100)
 
Very high expression (101 - 1000)
 
Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment   Expression Level
extended cold, 4-day adult
 
 4
cold shock, 4-day adult
 
 2
heat shock, 4-day adult
 
 10
Cadmium 50 mM 6 hrs, larvae L3
 
 11
Cadmium 50 mM 12 hrs, larvae L3
 
 7
Cadmium 50 mM 48 hrs, 4-day adult
 
 13
Cadmium 100 mM 48 hrs, 4-day adult
 
 5
Copper 0.5 mM 12 hrs, larvae L3
 
 8
Copper 15 mM 48 hrs, 4-day adult
 
 5
Zinc 5 mM 12 hrs, larvae L3
 
 7
Zinc 4.5 mM 48 hrs, 4-day adult
 
 8
Ethanol 2.5% 3 hrs, larvae L3
 
 6
Ethanol 5% 3 hrs, larvae L3
 
 13
Ethanol 10% 3 hrs, larvae L3
 
 12
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 10
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 5
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 3
Paraquat 5 mM 48 hrs, 4-day adult
 
 9
Paraquat 10 mM 48 hrs, 4-day adult
 
 11
Rotenone 2 μg 12 hrs, larvae L3
 
 10
Rotenone 8 μg 12 hrs, larvae L3
 
 13
Expression Level Scale
 Very low 
 Low 
 Moderate 
Linear, scaled to Moderate expression
Treatment   Expression Level
extended cold, 4-day adult
 
 4
cold shock, 4-day adult
 
 2
heat shock, 4-day adult
 
 10
Cadmium 50 mM 6 hrs, larvae L3
 
 11
Cadmium 50 mM 12 hrs, larvae L3
 
 7
Cadmium 50 mM 48 hrs, 4-day adult
 
 13
Cadmium 100 mM 48 hrs, 4-day adult
 
 5
Copper 0.5 mM 12 hrs, larvae L3
 
 8
Copper 15 mM 48 hrs, 4-day adult
 
 5
Zinc 5 mM 12 hrs, larvae L3
 
 7
Zinc 4.5 mM 48 hrs, 4-day adult
 
 8
Ethanol 2.5% 3 hrs, larvae L3
 
 6
Ethanol 5% 3 hrs, larvae L3
 
 13
Ethanol 10% 3 hrs, larvae L3
 
 12
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 10
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 5
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 3
Paraquat 5 mM 48 hrs, 4-day adult
 
 9
Paraquat 10 mM 48 hrs, 4-day adult
 
 11
Rotenone 2 μg 12 hrs, larvae L3
 
 10
Rotenone 8 μg 12 hrs, larvae L3
 
 13
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Treatment   Expression Level
extended cold, 4-day adult
 
 4
cold shock, 4-day adult
 
 2
heat shock, 4-day adult
 
 10
Cadmium 50 mM 6 hrs, larvae L3
 
 11
Cadmium 50 mM 12 hrs, larvae L3
 
 7
Cadmium 50 mM 48 hrs, 4-day adult
 
 13
Cadmium 100 mM 48 hrs, 4-day adult
 
 5
Copper 0.5 mM 12 hrs, larvae L3
 
 8
Copper 15 mM 48 hrs, 4-day adult
 
 5
Zinc 5 mM 12 hrs, larvae L3
 
 7
Zinc 4.5 mM 48 hrs, 4-day adult
 
 8
Ethanol 2.5% 3 hrs, larvae L3
 
 6
Ethanol 5% 3 hrs, larvae L3
 
 13
Ethanol 10% 3 hrs, larvae L3
 
 12
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 10
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 5
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 3
Paraquat 5 mM 48 hrs, 4-day adult
 
 9
Paraquat 10 mM 48 hrs, 4-day adult
 
 11
Rotenone 2 μg 12 hrs, larvae L3
 
 10
Rotenone 8 μg 12 hrs, larvae L3
 
 13
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Treatment   Expression Level
extended cold, 4-day adult
 
 4
cold shock, 4-day adult
 
 2
heat shock, 4-day adult
 
 10
Cadmium 50 mM 6 hrs, larvae L3
 
 11
Cadmium 50 mM 12 hrs, larvae L3
 
 7
Cadmium 50 mM 48 hrs, 4-day adult
 
 13
Cadmium 100 mM 48 hrs, 4-day adult
 
 5
Copper 0.5 mM 12 hrs, larvae L3
 
 8
Copper 15 mM 48 hrs, 4-day adult
 
 5
Zinc 5 mM 12 hrs, larvae L3
 
 7
Zinc 4.5 mM 48 hrs, 4-day adult
 
 8
Ethanol 2.5% 3 hrs, larvae L3
 
 6
Ethanol 5% 3 hrs, larvae L3
 
 13
Ethanol 10% 3 hrs, larvae L3
 
 12
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 10
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 5
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 3
Paraquat 5 mM 48 hrs, 4-day adult
 
 9
Paraquat 10 mM 48 hrs, 4-day adult
 
 11
Rotenone 2 μg 12 hrs, larvae L3
 
 10
Rotenone 8 μg 12 hrs, larvae L3
 
 13
Expression Level Scale
 Extremely high 
log, scaled to maximum expression level
Treatment   Expression Level
extended cold, 4-day adult
 
 4
cold shock, 4-day adult
 
 2
heat shock, 4-day adult
 
 10
Cadmium 50 mM 6 hrs, larvae L3
 
 11
Cadmium 50 mM 12 hrs, larvae L3
 
 7
Cadmium 50 mM 48 hrs, 4-day adult
 
 13
Cadmium 100 mM 48 hrs, 4-day adult
 
 5
Copper 0.5 mM 12 hrs, larvae L3
 
 8
Copper 15 mM 48 hrs, 4-day adult
 
 5
Zinc 5 mM 12 hrs, larvae L3
 
 7
Zinc 4.5 mM 48 hrs, 4-day adult
 
 8
Ethanol 2.5% 3 hrs, larvae L3
 
 6
Ethanol 5% 3 hrs, larvae L3
 
 13
Ethanol 10% 3 hrs, larvae L3
 
 12
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 10
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 5
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 3
Paraquat 5 mM 48 hrs, 4-day adult
 
 9
Paraquat 10 mM 48 hrs, 4-day adult
 
 11
Rotenone 2 μg 12 hrs, larvae L3
 
 10
Rotenone 8 μg 12 hrs, larvae L3
 
 13
Expression Level Scale
 Very low 
 Low 
 Moderate 
log, scaled to Moderate expression
Treatment   Expression Level
extended cold, 4-day adult
 
 4
cold shock, 4-day adult
 
 2
heat shock, 4-day adult
 
 10
Cadmium 50 mM 6 hrs, larvae L3
 
 11
Cadmium 50 mM 12 hrs, larvae L3
 
 7
Cadmium 50 mM 48 hrs, 4-day adult
 
 13
Cadmium 100 mM 48 hrs, 4-day adult
 
 5
Copper 0.5 mM 12 hrs, larvae L3
 
 8
Copper 15 mM 48 hrs, 4-day adult
 
 5
Zinc 5 mM 12 hrs, larvae L3
 
 7
Zinc 4.5 mM 48 hrs, 4-day adult
 
 8
Ethanol 2.5% 3 hrs, larvae L3
 
 6
Ethanol 5% 3 hrs, larvae L3
 
 13
Ethanol 10% 3 hrs, larvae L3
 
 12
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 10
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 5
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 3
Paraquat 5 mM 48 hrs, 4-day adult
 
 9
Paraquat 10 mM 48 hrs, 4-day adult
 
 11
Rotenone 2 μg 12 hrs, larvae L3
 
 10
Rotenone 8 μg 12 hrs, larvae L3
 
 13
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Treatment   Expression Level
extended cold, 4-day adult
 
 4
cold shock, 4-day adult
 
 2
heat shock, 4-day adult
 
 10
Cadmium 50 mM 6 hrs, larvae L3
 
 11
Cadmium 50 mM 12 hrs, larvae L3
 
 7
Cadmium 50 mM 48 hrs, 4-day adult
 
 13
Cadmium 100 mM 48 hrs, 4-day adult
 
 5
Copper 0.5 mM 12 hrs, larvae L3
 
 8
Copper 15 mM 48 hrs, 4-day adult
 
 5
Zinc 5 mM 12 hrs, larvae L3
 
 7
Zinc 4.5 mM 48 hrs, 4-day adult
 
 8
Ethanol 2.5% 3 hrs, larvae L3
 
 6
Ethanol 5% 3 hrs, larvae L3
 
 13
Ethanol 10% 3 hrs, larvae L3
 
 12
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 10
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 5
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 3
Paraquat 5 mM 48 hrs, 4-day adult
 
 9
Paraquat 10 mM 48 hrs, 4-day adult
 
 11
Rotenone 2 μg 12 hrs, larvae L3
 
 10
Rotenone 8 μg 12 hrs, larvae L3
 
 13
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Treatment   Expression Level
extended cold, 4-day adult
 
 4
cold shock, 4-day adult
 
 2
heat shock, 4-day adult
 
 10
Cadmium 50 mM 6 hrs, larvae L3
 
 11
Cadmium 50 mM 12 hrs, larvae L3
 
 7
Cadmium 50 mM 48 hrs, 4-day adult
 
 13
Cadmium 100 mM 48 hrs, 4-day adult
 
 5
Copper 0.5 mM 12 hrs, larvae L3
 
 8
Copper 15 mM 48 hrs, 4-day adult
 
 5
Zinc 5 mM 12 hrs, larvae L3
 
 7
Zinc 4.5 mM 48 hrs, 4-day adult
 
 8
Ethanol 2.5% 3 hrs, larvae L3
 
 6
Ethanol 5% 3 hrs, larvae L3
 
 13
Ethanol 10% 3 hrs, larvae L3
 
 12
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 10
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 5
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 3
Paraquat 5 mM 48 hrs, 4-day adult
 
 9
Paraquat 10 mM 48 hrs, 4-day adult
 
 11
Rotenone 2 μg 12 hrs, larvae L3
 
 10
Rotenone 8 μg 12 hrs, larvae L3
 
 13
Expression Level Scale
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Treatment   Expression Level
extended cold, 4-day adult
 
 
cold shock, 4-day adult
 
 
heat shock, 4-day adult
 
 
Cadmium 50 mM 6 hrs, larvae L3
 
 
Cadmium 50 mM 12 hrs, larvae L3
 
 
Cadmium 50 mM 48 hrs, 4-day adult
 
 
Cadmium 100 mM 48 hrs, 4-day adult
 
 
Copper 0.5 mM 12 hrs, larvae L3
 
 
Copper 15 mM 48 hrs, 4-day adult
 
 
Zinc 5 mM 12 hrs, larvae L3
 
 
Zinc 4.5 mM 48 hrs, 4-day adult
 
 
Ethanol 2.5% 3 hrs, larvae L3
 
 
Ethanol 5% 3 hrs, larvae L3
 
 
Ethanol 10% 3 hrs, larvae L3
 
 
Caffeine 1.5 mg/ml 4 hrs, larvae L3
 
 
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
 
 
Caffeine 25 mg/ml 48 hrs, 4-day adult
 
 
Paraquat 5 mM 48 hrs, 4-day adult
 
 
Paraquat 10 mM 48 hrs, 4-day adult
 
 
Rotenone 2 μg 12 hrs, larvae L3
 
 
Rotenone 8 μg 12 hrs, larvae L3
 
 

hide Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
hide External Data & Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
hide Alleles & Phenotypes
hide Summary of Allele Phenotypes
Lethality
Allele
Sterility
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
filopodium & abdominal ventral longitudinal muscle 3
muscle attachment site & basal lamina
muscle attachment site & connecting hemi-adherens junction
muscle attachment site & muscle tendon junction
sarcomere & somatic muscle
hide Classical Alleles ( 54 )
For All Classical Alleles Show

Allele of ifClassMutagenStocksKnown lesion
ifB2loss of function allele, amorphic allele - genetic evidence, hypomorphic allele - genetic evidence2 --
ifk27eamorphic allele - genetic evidence, loss of function allele2 --
if32 --
ifMB10541
1 --
if16amorphic allele - genetic evidence0 --
if26amorphic allele - genetic evidence0 --
if2B2amorphic allele - genetic evidence0 --
if2B3amorphic allele - genetic evidence0 --
if38amorphic allele - genetic evidence0 --
if4.5amorphic allele - genetic evidence0 --
if648amorphic allele - genetic evidence0 --
if64amorphic allele - genetic evidence0 --
if6amorphic allele - genetic evidence0 --
if8amorphic allele - genetic evidence0 --
if9amorphic allele - genetic evidence0 --
ifA2amorphic allele - genetic evidence0 --
ifA7loss of function allele, amorphic allele - genetic evidence0 --
ifB4loss of function allele, amorphic allele - genetic evidence0 Yes
ifB6amorphic allele - genetic evidence0 Yes
ifC1Aamorphic allele - genetic evidence0 --
ifC3Camorphic allele - genetic evidence0 --
ifC4Damorphic allele - genetic evidence0 --
ifC5Eamorphic allele - genetic evidence0 --
ifK13amorphic allele - genetic evidence0 --
ifK23amorphic allele - genetic evidence0 --
ifL10amorphic allele - genetic evidence0 --
ifL13amorphic allele - genetic evidence0 --
ifL326amorphic allele - genetic evidence0 --
ifL6amorphic allele - genetic evidence0 --
ifM2amorphic allele - genetic evidence0 --
ifN18Ramorphic allele - genetic evidence0 --
ifN19Samorphic allele - genetic evidence0 --
ifO11Kamorphic allele - genetic evidence0 --
ifO17Qamorphic allele - genetic evidence0 --
ifO2amorphic allele - genetic evidence0 --
ifO2Bamorphic allele - genetic evidence0 --
ifO9Iamorphic allele - genetic evidence0 --
ifQ2Bamorphic allele - genetic evidence0 --
if13tshypomorphic allele - genetic evidence0 --
if17hypomorphic allele - genetic evidence0 Yes
if10 --
if21hypomorphic allele - genetic evidence0 Yes
if2
0 --
if2B10 Yes
if35hypomorphic allele - genetic evidence0 Yes
if815-170 --
ifB2.10 --
ifC2B0 Yes
ifCPTI0041520 Yes
ifGG01583
0 --
ifH18
0 --
ifN0 --
ifSEF0 Yes
ifunspecified
0 --
hide Alleles Carried on Transgenic Constructs ( 31 )
For All Alleles Carried on Transgenic Constructs Show

Allele of ifClassMutagenStocksKnown lesion
ifGD11752 Yes
ifHMS018721 Yes
ifJF026951 Yes
ifKK1085441 Yes
if+t390 Yes
if+tBa0 Yes
ifC.hs0 Yes
ifC.Scer\UAS0 Yes
ifGFANA.hs0 Yes
ifGOF.C.hs0 Yes
ifGOF.m8.hs0 Yes
ifGOF.m8.Scer\UAS0 Yes
ifLOF.C.hs0 Yes
ifLOF.m8.hs0 Yes
ifLOF.m8.Scer\UAS0 Yes
ifm8.hs0 Yes
ifm8.Scer\FRT.αTub84B0 Yes
ifm8.Scer\UAS0 Yes
ifm8.αTub84B0 Yes
ifminigene0 Yes
ifMtnA.PG0 Yes
ifNIG.9623R0 Yes
ifScer\UAS.cMBa0 Yes
ifScer\UAS.cUa0 Yes
ifΔ.C.hs0 Yes
ifΔ.C.Scer\UAS0 Yes
ifΔ.m8.hs0 Yes
ifΔ.m8.Scer\UAS0 Yes
ifΔcyt.Scer\UAS0 Yes
ifΔGFFNR.Scer\UAS0 Yes
ifΔGFFNR0 Yes
hide Aneuploid Aberrations
Disrupted in
Duplicated in
Not disrupted in
Not duplicated in
hide Transgenic Constructs & Insertions
Transgenic Constructs
Type of construct
Name
Expression data
Insertions
Type of insertions
Name
Expression data
insertion of mobile activating element
insertion of enhancer trap binary system
miscellaneous insertions
hide Gene Ontology: Function, Process & Cellular Component ( 27 unique terms )
hide Terms Based on Experimental Evidence ( 17 terms )
Molecular Function
CV term
References
inferred from direct assay
Biological Process
CV term
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
inferred from mutant phenotype
inferred from expression pattern AND inferred from mutant phenotype
inferred from genetic interaction with Grip
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with βTub85D
inferred from genetic interaction with sws
Cellular Component
CV term
References
inferred from direct assay
inferred from direct assay
hide Terms Based on Predictions or Assertions ( 13 terms )
Molecular Function
CV term
References
inferred from sequence or structural similarity
inferred from sequence or structural similarity
Biological Process
CV term
References
traceable author statement
inferred from sequence or structural similarity
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Cellular Component
CV term
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Interacts with
Please look at the allele data for full details of the genetic interactions
if allele
Gene
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BioGRID - A database of protein and genetic interactions
DroID - A comprehensive database of gene and protein interactions.
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
hide Orthologs
hide OrthoDB Orthologs (34) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
Drosophila inclusive ortholog search
Dipteran inclusive ortholog search
Insect inclusive ortholog search
Arthropod inclusive ortholog search
Metazoa inclusive ortholog search
hideOrthologs in Drosophila Species (EOG6RJGKV)
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly 
 
 
Drosophila simulans
 
Y
 
Drosophila sechellia
 
Y
 
Drosophila erecta
 
Y
 
Drosophila yakuba
 
Y
 
Drosophila ananassae
 
Y
 
Drosophila pseudoobscura pseudoobscura
 
Y
 
Drosophila persimilis
 
Y
 
Drosophila willistoni
 
Y
 
Drosophila virilis
 
Y
 
Drosophila mojavensis
 
Y
 
Drosophila grimshawi
 
Y
 
hideOrthologs in non-Drosophila Dipterans (EOG67WNWN)
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Aedes aegypti
Yellow fever mosquito 
 
Anopheles gambiae
Malaria mosquito 
 
Culex quinquefasciatus
Southern house mosquito 
 
hideOrthologs in non-Dipteran Insects (EOG63TXQK)
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Apis mellifera
Western honey bee 
Amel\GB49921
 
Nasonia vitripennis
Parasitic wasp 
Nvit\Nasvi2EG012335
 
Acromyrmex echinatior
Panamanian leafcutter ant 
Aech\AECH20346
 
Atta cephalotes
Leafcutter ant 
Acep\ACEP25232
 
Camponotus floridanus
Florida carpenter ant 
Cflo\CFLO14460
 
Harpegnathos saltator
Jerdons jumping ant 
Hsal\HSAL14952
 
Linepithema humile
Argentine ant 
Lhum\LH16573
 
Pogonomyrmex barbatus
Red harvester ant 
Pbar\PB20828
 
Solenopsis invicta
Red fire ant 
Sinv\SINV13588
 
Acyrthosiphon pisum
Pea aphid 
 
Bombyx mori
Silkmoth 
 
Pediculus humanus
Human body louse 
 
Tribolium castaneum
Red flour beetle 
 
hideOrthologs in non-Insect Arthropods (EOG6CFXQ8)
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Daphnia pulex
Water flea 
 
hideOrthologs in non-Arthropod Metazoa (EOG6VTJQ6)
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Caenorhabditis elegans
Nematode 
 
Strongylocentrotus purpuratus
Purple sea urchin 
 
Strongylocentrotus purpuratus
Purple sea urchin 
 
Strongylocentrotus purpuratus
Purple sea urchin 
 
Strongylocentrotus purpuratus
Purple sea urchin 
 
hide Human Orthologs (0)
Gene
OMIM
HGNC
hideAAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism
Gene
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
hide Stocks & Reagents
hide Stocks Listed in FlyBase ( 12 )
Bloomington
3960
Kyoto
107534
VDRC
hide Genomic Clones ( 2 )
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
hide cDNA Clones ( 48 )
Please Note
This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
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ChEST reveals this is a target of Mef2.
RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in S2R+ cells: cells become round and detached. Kc167 cells are unaffected.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
if is required in the visceral mesoderm for normal migration of the endodermal midgut cells over the visceral mesoderm in the developing embryo.
Class I and class II alleles fully complement class IV alleles. Class II alleles fully complement class III alleles. if13ts class I allele fully complements class II alleles, but the transheterozygotes between other class I alleles and class III allele generally die, although a few adult escapers are observed.
Mutational analysis reveals if is required for the development of the adult halteres and legs, as well as the wing. if is required for the formation of the somatic muscle sarcomeric structure, rather than for its maintenance. The function of if in the morphogenesis of the midgut and nerve cord is distinct from its function in muscle attachment and sarcomeric structure.
The functional significance of the cytoplasmic domains of the if, mew and mys subunits of the Position Specific (PS) integrin family are studied by analysing the relationship between the cytoplasmic domain structure and function in the context of a developing organism. The cytoplasmic tail of if is essential for both embryonic and postembryonic processes.
Modulation of integrin function through the cytoplasmic domain of if is essential for embryonic morphogenesis.
if is essential for the adhesion of muscle and epidermal hemiadherens junctions to extracellular matrix at muscle attachment sites in the developing embryo.
The ability of two different integrin α subunits (encoded by mew and if) to substitute for each other during embryonic development has been studied. The two α subunits encoded by mew and if are not equivalent and have distinct functions which reside in the extracellular domains.
Clonal analysis demonstrates that the different integrins, mew and if, are required on opposite wing epithelia. An early integrin-dependent process, not obviously required for prepupal adhesion, is essential to permit subsequent wing morphogenesis.
if and mys can be localised by an intracellular mechanism within the muscles. Direct localisation of the transmembrane protein to sites of integrin function occurs in cells that lack endogenous mys and if or cells that lack extracellular signals from the tendon cells.
Either splice form of if is sufficient for viability, but they do have distinct requirements during development. if function can replace mew function in the retina.
Phenotypic analysis of mew, if and mys embryos suggests multiple roles for PS integrins in the adhesion of cells and in the formation, organization and migration of embryonic tissues. Although the proteins are often expressed in adjacent embryonic tissues, this distribution does not necessarily reflect equivalent requirements. The complete loss of both α subunits, encoded by mew and if, does not produce all the phenotypes observed in embryos lacking the mys encoded β subunit.
Molecular and genetic analysis prove that the αPS2 integrin subunit is encoded by the if locus. Comparison of the null phenotypes of mys (encoding the ΒPS integrin subunit) and if rules out a model where PS integrin function occurs solely by the direct interaction of the two PS integrins, αPS1ΒPS and αPS2ΒPS.
if has been expressed on the surface of Drosophila tissue culture cells. if gene product promotes cell spreading on two different extra cellular matrix (ECM) molecules, laminin and tiggin.
Muscle phenotype of mutants studied using polarised light microscopy and antibody staining to detect Mhc-lacZ reporter gene expression in muscles.
The distribution of mew, if and scb proteins in cultured cell lines has been investigated.
Scaffold attachment regions in the region surrounding if have been mapped.
if gene product is the PS2α integrin subunit. if is required to ensure the correct apposition and patterning of the wing epithelia.
Structural gene for the α-subunit of position specific integrin 2 (PS2), a large transmembrane protein (Bogaert, Brown and Wilcox, 1987). The β-subunit can associate with either of the two α-subunits, PS1 or PS2 (Brower et al., 1984; Wilcox et al., 1984). Both α and β integrin are expressed in embryonic and larval tissues. In early development, PS2 is found in the mesoderm, localized to muscle attachments (Bogaert, Brown and Wilcox, 1987). Later, PS1 is expressed in the presumptive dorsal epithelium of the third instar imaginal wing discs; also, PS2 is found in the ventral epithelium, both integrins being important for the joining of the dorsal and ventral surfaces of the wing blade (Brower and Jaffe, 1989). Null mutations cause embryonic lethality (Wilcox, DiAntonio and Leptin, 1989). In the mutant if1, the adult wing is inflated with lymph and smaller than normal; venation is defective. Wings later become dry and blistered.
 
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Sequence Crossreferences
RefSeq (Transcripts)
RefSeq (Proteins)
Entrez Gene - A searchable database of RefSeq genes.
Other Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
Linkouts
BioGRID - A database of protein and genetic interactions
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results from RNAi screens.
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
modMine - Data generated by the modENCODE project.
REDfly - A database of transcriptional regulatory elements.
hide Synonyms & Secondary IDs ( 29 )
Reported As
Symbol Synonym
αPS2(ms8)
Name Synonym
Integrin αPS2 subunit
position-specific antigen 2
α2 integrin
αPS2 integrin
α-PS2-integrin
αPS2 Integrin
Secondary FlyBase IDs
hide References ( 265 )
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hide Recent research papers ( 16 )
Enriquez et al., 2012, Dev. Biol. 363(1): 27--39
Combinatorial coding of Drosophila muscle shape by Collier and Nautilus. [FBrf0217465]
Goulas et al., 2012, Cell Stem Cell 11(4): 529--540
The par complex and integrins direct asymmetric cell division in adult intestinal stem cells. [FBrf0219511]
Han et al., 2012, FEBS Lett. 586(22): 4031--4037
Tsp66E, the Drosophila KAI1 homologue, and Tsp74F function to regulate ovarian follicle cell and wing development by stabilizing integrin localization. [FBrf0219949]
Kim et al., 2012, Neuron 73(1): 79--91
Integrins Establish Dendrite-Substrate Relationships that Promote Dendritic Self-Avoidance and Patterning in Drosophila Sensory Neurons. [FBrf0217191]
Kókai et al., 2012, BMC Dev. Biol. 12: 20
CalpB modulates border cell migration in Drosophila egg chambers. [FBrf0219464]
Yang and Terman, 2012, Neuron 74(1): 108--121
14-3-3ε couples protein kinase A to semaphorin signaling and silences plexin RasGAP-mediated axonal repulsion. [FBrf0218615]
Zhai et al., 2012, PLoS Genet. 8(3): e1002582
Antagonistic regulation of apoptosis and differentiation by the cut transcription factor represents a tumor-suppressing mechanism in Drosophila. [FBrf0217859]
Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784
GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834]
Egoz-Matia et al., 2011, Dev. Biol. 351(1): 99--109
Spatial regulation of cell adhesion in the Drosophila wing is mediated by Delilah, a potent activator of βPS integrin expression. [FBrf0213026]
Ellis et al., 2011, J. Cell Sci. 124(11): 1844--1856
In vivo functional analysis reveals specific roles for the integrin-binding sites of talin. [FBrf0213701]
Kendall et al., 2011, J. Biol. Chem. 286(35): 30981--30993
Identification of Integrin {beta} Subunit Mutations That Alter Affinity for Extracellular Matrix Ligand. [FBrf0214781]
Pines et al., 2011, Dev. Dyn. 240(1): 36--51
Distinct regulatory mechanisms control integrin adhesive processes during tissue morphogenesis. [FBrf0212613]
Ribeiro et al., 2011, PLoS Genet. 7(2): e1001295
Phosphoinositide regulation of integrin trafficking required for muscle attachment and maintenance. [FBrf0213137]
Urbano et al., 2011, PLoS ONE 6(9): e23893
PS Integrins and Laminins: Key Regulators of Cell Migration during Drosophila Embryogenesis. [FBrf0216260]
Xie and Auld, 2011, Development 138(17): 3813--3822
Integrins are necessary for the development and maintenance of the glial layers in the Drosophila peripheral nerve. [FBrf0214589]
Zervas et al., 2011, J. Cell Sci. 124(8): 1316--1327
A central multifunctional role of integrin-linked kinase at muscle attachment sites. [FBrf0213331]
hide Recent reviews ( 1 )
Broadie et al., 2011, Dev. Neurobiol. 71(11): 1102--1130
Extracellular matrix and its receptors in drosophila neural development. [FBrf0216377]