General Information
Symbol
Dmel\if
Species
D. melanogaster
Name
inflated
Annotation Symbol
CG9623
Feature Type
FlyBase ID
FBgn0001250
Gene Model Status
Stock Availability
Gene Snapshot
Inflated is one of 5 fly integrin alpha subunits, and when in a heterodimer with an integrin beta subunit makes a receptor for extracellular matrix proteins containing an RGD motif, such as Tig, wb laminin and Tsp. It is required in numerous tissues for cell migration and adhesion between cell layers. [Date last reviewed: 2016-12-01]
Also Known As
αPS2, αPS2, PS2, PS2α, PS 2
Genomic Location
Cytogenetic map
Sequence location
X:16,752,189..16,783,434 [-]
Recombination map
1-55
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
GO Summary Ribbons
Families, Domains and Molecular Function
Gene Group Membership (FlyBase)
Protein Family (UniProt, Sequence Similarities)
Belongs to the integrin alpha chain family. (P12080)
Molecular Function (see GO section for details)
Experimental Evidence
Predictions / Assertions
-
Summaries
Gene Group Membership
INTEGRINS -
Integrins are heterodimeric transmembrane receptors composed of an α and β subunit that mediate cell-cell and cell-extracellular matrix adhesion. As well as maintaining tissue integrity, they are involved in morphogenesis and development. (Adapted from FBrf0167428).
UniProt Contributed Function Data
Alpha-PS2/beta-PS is a receptor for Tig, wb and Ten-m. Involved in the function and/or development of the olfactory system.
(UniProt, P12080)
Phenotypic Description from the Red Book (Lindsley and Zimm 1992)
if: inflated
Structural gene for the α-subunit of position specific integrin 2 (PS2), a large transmembrane protein (Bogaert et al., 1987). The β-subunit can associate with either of the two α-subunits, PS1 or PS2 (Brower et al., 1984; Wilcox, Brown, Piovant, Smith, and White, 1984, EMBO J. 3: 2307-13). Both α and β integrin are expressed in embryonic and larval tissues. In early development, PS2 is found in the mesoderm, localized to muscle attachments (Bogaert et al., 1987). Later, PS1 is expressed in the presumptive dorsal epithelium of the third instar imaginal wing discs; also, PS2 is found in the ventral epithelium, both integrins being important for the joining of the dorsal and ventral surfaces of the wing blade (Brower and Jaffe, 1989). Null mutations cause embryonic lethality (Wilcox, DiAntonio, and Leptin). In the mutant if1, the adult wing is inflated with lymph and smaller than normal; venation is defective. Wings later become dry and blistered.
if3
Longitudinal veins thickened, especially at wing base. Anterior crossvein thickened. if3/if3 flies show reduced levels of PS2 integrin on the surfaces of some imaginal disc cells (especially in the ventral region), but levels of this integrin in muscle, salivary glands, and most other tissues seem to be normal (Brower and Jaffe, 1989). Adult wings typically show large round wing blisters, but the penetrance of this phenotype in homo- and hemizygotes is variable. if3/ifk27e flies show an increase in penetrance (from 15-20% in homozygotes to 60-70% in the heteroalleles); penetrance is reduced in if3/ifk27e flies by low temperature and crowding (Brower and Jaffe, 1989).
ifN
Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\if or the JBrowse view of Dmel\if for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Low-frequency RNA-Seq exon junction(s) not annotated.
Supported by strand-specific RNA-Seq data.
Gene model reviewed during 5.52
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0074357
5724
1396
FBtr0301352
5649
1371
FBtr0301353
5683
1396
FBtr0301354
5818
1396
Additional Transcript Data and Comments
Reported size (kB)
5.7 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0074131
154.3
1396
6.10
FBpp0290566
151.6
1371
6.04
FBpp0290567
154.3
1396
6.10
FBpp0290568
154.3
1396
6.10
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1396 aa isoforms: if-PB, if-PD, if-PF
Additional Polypeptide Data and Comments
Reported size (kDa)
1394 (aa); 140 (kD observed)
Comments
External Data
Subunit Structure (UniProtKB)
Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-PS2 associates with beta-PS.
(UniProt, P12080)
Post Translational Modification
The heavy-light chain cleavage site is either in 1230-1231, or 1233-1234, or 1243-1244.
(UniProt, P12080)
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\if using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (33 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (0 terms)
Biological Process (24 terms)
Terms Based on Experimental Evidence (17 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from expression pattern
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
Terms Based on Predictions or Assertions (8 terms)
CV Term
Evidence
References
Cellular Component (6 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
non-traceable author statement
inferred from sequence or structural similarity
traceable author statement
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
radioisotope in situ
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
if transcripts are expressed throughout development and in adults. In embryos, they are first detected at stage 4 in the presumptive mesoderm. They continue to be expressed in mesodermal cells after invagination. In third instar larval wing discs, if transcripts are primarily restricted to the ventral compartment and to the peripodial membrane.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
if staining is seen in follicle cell membranes by staining of unfixed, unpermeabilized ovaries followed by fixation and dissection.
if protein is first detected in stage 10 embryos in the mesoderm where it is basally concentrated in cuboidal cells which lie on the ectoderm. After the somatic and visceral mesoderm separates, if protein is found on the basal cell surfaces of the visceral myoblasts when they attach to the foregut, midgut, and hindgut. It is also found at the sites of attachment of the somatic muscles. Protein was also detected in the gonadal sheath and in the interstitial cells of the gonad In third instar larval wing discs, if protein is primarily restricted to the ventral compartment.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\if in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 56 )
For All Classical and Insertion Alleles Show
 
Allele of if
Class
Mutagen
Associated Insertion
Stocks
Known lesion
    0
    --
      0
      --
      Other relevant insertions
      insertion of mobile activating element
      Name
      Expression Data
      Transgenic Constructs ( 24 )
      For All Alleles Carried on Transgenic Constructs Show
      Transgenic constructs containing/affecting coding region of if
      Allele of if
      Mutagen
      Associated Transgenic Construct
      Stocks
      Transgenic constructs containing regulatory region of if
      characterization construct
      reporter construct
      Deletions and Duplications ( 30 )
      Phenotypes
      For more details about a specific phenotype click on the relevant allele symbol.
      Lethality
      Allele
      Sterility
      Allele
      Other Phenotypes
      Allele
      Phenotype manifest in
      Allele
      filopodium & abdominal ventral longitudinal muscle 3
      muscle attachment site & basal lamina
      muscle attachment site & connecting hemi-adherens junction
      muscle attachment site & muscle tendon junction
      sarcomere & somatic muscle
      Orthologs
      Human Orthologs (via DIOPT v7.1)
      Homo sapiens (Human) (15)
      Species\Gene Symbol
      Score
      Best Score
      Best Reverse Score
      Alignment
      Complementation?
      Transgene?
      12 of 15
      Yes
      Yes
       
      11 of 15
      No
      Yes
      10 of 15
      No
      Yes
       
      9 of 15
      No
      Yes
      2 of 15
      No
      No
      2 of 15
      No
      No
      2 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
       
      1 of 15
      No
      No
      1 of 15
      No
      No
      Model Organism Orthologs (via DIOPT v7.1)
      Mus musculus (laboratory mouse) (16)
      Species\Gene Symbol
      Score
      Best Score
      Best Reverse Score
      Alignment
      Complementation?
      Transgene?
      12 of 15
      Yes
      Yes
      11 of 15
      No
      Yes
      10 of 15
      No
      Yes
      9 of 15
      No
      Yes
      2 of 15
      No
      No
      2 of 15
      No
      No
      2 of 15
      No
      Yes
      2 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
      Rattus norvegicus (Norway rat) (14)
      11 of 13
      Yes
      Yes
      5 of 13
      No
      Yes
      3 of 13
      No
      Yes
      3 of 13
      No
      Yes
      2 of 13
      No
      No
      2 of 13
      No
      No
      2 of 13
      No
      No
      2 of 13
      No
      Yes
      1 of 13
      No
      No
      1 of 13
      No
      No
      1 of 13
      No
      No
      1 of 13
      No
      No
      1 of 13
      No
      No
      1 of 13
      No
      No
      Xenopus tropicalis (Western clawed frog) (5)
      7 of 12
      Yes
      Yes
      6 of 12
      No
      Yes
      5 of 12
      No
      Yes
      3 of 12
      No
      Yes
      2 of 12
      No
      Yes
      Danio rerio (Zebrafish) (19)
      11 of 15
      Yes
      Yes
      7 of 15
      No
      Yes
      6 of 15
      No
      Yes
      4 of 15
      No
      Yes
      2 of 15
      No
      No
      2 of 15
      No
      No
      2 of 15
      No
      No
      2 of 15
      No
      Yes
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      Yes
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      No
      1 of 15
      No
      Yes
      1 of 15
      No
      Yes
      Caenorhabditis elegans (Nematode, roundworm) (1)
      13 of 15
      Yes
      Yes
      Arabidopsis thaliana (thale-cress) (0)
      No orthologs reported.
      Saccharomyces cerevisiae (Brewer's yeast) (1)
      1 of 15
      Yes
      Yes
      Schizosaccharomyces pombe (Fission yeast) (0)
      No orthologs reported.
      Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091900RZ )
      Organism
      Common Name
      Gene
      AAA Syntenic Ortholog
      Multiple Dmel Genes in this Orthologous Group
      Drosophila melanogaster
      fruit fly
      Drosophila suzukii
      Spotted wing Drosophila
      Drosophila simulans
      Drosophila sechellia
      Drosophila erecta
      Drosophila yakuba
      Drosophila ananassae
      Drosophila pseudoobscura pseudoobscura
      Drosophila persimilis
      Drosophila willistoni
      Drosophila virilis
      Drosophila mojavensis
      Drosophila grimshawi
      Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500OH )
      Organism
      Common Name
      Gene
      Multiple Dmel Genes in this Orthologous Group
      Musca domestica
      House fly
      Glossina morsitans
      Tsetse fly
      Lucilia cuprina
      Australian sheep blowfly
      Mayetiola destructor
      Hessian fly
      Aedes aegypti
      Yellow fever mosquito
      Anopheles darlingi
      American malaria mosquito
      Anopheles gambiae
      Malaria mosquito
      Culex quinquefasciatus
      Southern house mosquito
      Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01PT )
      Organism
      Common Name
      Gene
      Multiple Dmel Genes in this Orthologous Group
      Bombyx mori
      Silkmoth
      Danaus plexippus
      Monarch butterfly
      Heliconius melpomene
      Postman butterfly
      Apis florea
      Little honeybee
      Apis mellifera
      Western honey bee
      Bombus impatiens
      Common eastern bumble bee
      Bombus terrestris
      Buff-tailed bumblebee
      Linepithema humile
      Argentine ant
      Megachile rotundata
      Alfalfa leafcutting bee
      Nasonia vitripennis
      Parasitic wasp
      Dendroctonus ponderosae
      Mountain pine beetle
      Tribolium castaneum
      Red flour beetle
      Pediculus humanus
      Human body louse
      Rhodnius prolixus
      Kissing bug
      Cimex lectularius
      Bed bug
      Cimex lectularius
      Bed bug
      Acyrthosiphon pisum
      Pea aphid
      Zootermopsis nevadensis
      Nevada dampwood termite
      Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01NQ )
      Organism
      Common Name
      Gene
      Multiple Dmel Genes in this Orthologous Group
      Strigamia maritima
      European centipede
      Strigamia maritima
      European centipede
      Strigamia maritima
      European centipede
      Ixodes scapularis
      Black-legged tick
      Stegodyphus mimosarum
      African social velvet spider
      Stegodyphus mimosarum
      African social velvet spider
      Tetranychus urticae
      Two-spotted spider mite
      Daphnia pulex
      Water flea
      Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G02JI )
      Organism
      Common Name
      Gene
      Multiple Dmel Genes in this Orthologous Group
      Strongylocentrotus purpuratus
      Purple sea urchin
      Strongylocentrotus purpuratus
      Purple sea urchin
      Strongylocentrotus purpuratus
      Purple sea urchin
      Strongylocentrotus purpuratus
      Purple sea urchin
      Strongylocentrotus purpuratus
      Purple sea urchin
      Strongylocentrotus purpuratus
      Purple sea urchin
      Strongylocentrotus purpuratus
      Purple sea urchin
      Strongylocentrotus purpuratus
      Purple sea urchin
      Strongylocentrotus purpuratus
      Purple sea urchin
      Ciona intestinalis
      Vase tunicate
      Human Disease Model Data
      FlyBase Human Disease Model Reports
        Alleles Reported to Model Human Disease (Disease Ontology)
        Download
        Models ( 0 )
        Allele
        Disease
        Evidence
        References
        Interactions ( 0 )
        Allele
        Disease
        Interaction
        References
        Comments ( 0 )
         
        Human Orthologs (via DIOPT v7.1)
        Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser

        Please look at the Interaction Group reports for full details of the physical interactions
        protein-protein
        Interacting group
        Assay
        References
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement

        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Subunit Structure (UniProtKB)
        Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Alpha-PS2 associates with beta-PS.
        (UniProt, P12080 )
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        Pathways
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        X
        Recombination map
        1-55
        Cytogenetic map
        Sequence location
        X:16,752,189..16,783,434 [-]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        15A5-15A7
        Limits computationally determined from genome sequence between P{EP}EP1547EP1547 and P{EP}CG4928EP1341
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        15A1-15A5
        (determined by in situ hybridisation)
        Experimentally Determined Recombination Data
        Left of (cM)
        Notes
        Stocks and Reagents
        Stocks (15)
        Genomic Clones (24)
        cDNA Clones (37)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequences
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           
          monoclonal, polyclonal
          Commercially Available Antibodies
           
          Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
          Other Information
          Relationship to Other Genes
          Source for database identify of
          Source for database merge of
          Additional comments
          Other Comments
          ChEST reveals this is a target of Mef2.
          dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
          RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in S2R+ cells: cells become round and detached. Kc167 cells are unaffected.
          if is required in the visceral mesoderm for normal migration of the endodermal midgut cells over the visceral mesoderm in the developing embryo.
          Class I and class II alleles fully complement class IV alleles. Class II alleles fully complement class III alleles. if13ts class I allele fully complements class II alleles, but the transheterozygotes between other class I alleles and class III allele generally die, although a few adult escapers are observed.
          Mutational analysis reveals if is required for the development of the adult halteres and legs, as well as the wing. if is required for the formation of the somatic muscle sarcomeric structure, rather than for its maintenance. The function of if in the morphogenesis of the midgut and nerve cord is distinct from its function in muscle attachment and sarcomeric structure.
          The functional significance of the cytoplasmic domains of the if, mew and mys subunits of the Position Specific (PS) integrin family are studied by analysing the relationship between the cytoplasmic domain structure and function in the context of a developing organism. The cytoplasmic tail of if is essential for both embryonic and postembryonic processes.
          Modulation of integrin function through the cytoplasmic domain of if is essential for embryonic morphogenesis.
          if is essential for the adhesion of muscle and epidermal hemiadherens junctions to extracellular matrix at muscle attachment sites in the developing embryo.
          The ability of two different integrin α subunits (encoded by mew and if) to substitute for each other during embryonic development has been studied. The two α subunits encoded by mew and if are not equivalent and have distinct functions which reside in the extracellular domains.
          Clonal analysis demonstrates that the different integrins, mew and if, are required on opposite wing epithelia. An early integrin-dependent process, not obviously required for prepupal adhesion, is essential to permit subsequent wing morphogenesis.
          if and mys can be localised by an intracellular mechanism within the muscles. Direct localisation of the transmembrane protein to sites of integrin function occurs in cells that lack endogenous mys and if or cells that lack extracellular signals from the tendon cells.
          Either splice form of if is sufficient for viability, but they do have distinct requirements during development. if function can replace mew function in the retina.
          Phenotypic analysis of mew, if and mys embryos suggests multiple roles for PS integrins in the adhesion of cells and in the formation, organization and migration of embryonic tissues. Although the proteins are often expressed in adjacent embryonic tissues, this distribution does not necessarily reflect equivalent requirements. The complete loss of both α subunits, encoded by mew and if, does not produce all the phenotypes observed in embryos lacking the mys encoded β subunit.
          Molecular and genetic analysis prove that the αPS2 integrin subunit is encoded by the if locus. Comparison of the null phenotypes of mys (encoding the ΒPS integrin subunit) and if rules out a model where PS integrin function occurs solely by the direct interaction of the two PS integrins, αPS1ΒPS and αPS2ΒPS.
          if has been expressed on the surface of Drosophila tissue culture cells. if gene product promotes cell spreading on two different extra cellular matrix (ECM) molecules, laminin and tiggin.
          Muscle phenotype of mutants studied using polarised light microscopy and antibody staining to detect Mhc-lacZ reporter gene expression in muscles.
          The distribution of mew, if and scb proteins in cultured cell lines has been investigated.
          Scaffold attachment regions in the region surrounding if have been mapped.
          if gene product is the PS2α integrin subunit. if is required to ensure the correct apposition and patterning of the wing epithelia.
          Structural gene for the α-subunit of position specific integrin 2 (PS2), a large transmembrane protein (Bogaert, Brown and Wilcox, 1987). The β-subunit can associate with either of the two α-subunits, PS1 or PS2 (Brower et al., 1984; Wilcox et al., 1984). Both α and β integrin are expressed in embryonic and larval tissues. In early development, PS2 is found in the mesoderm, localized to muscle attachments (Bogaert, Brown and Wilcox, 1987). Later, PS1 is expressed in the presumptive dorsal epithelium of the third instar imaginal wing discs; also, PS2 is found in the ventral epithelium, both integrins being important for the joining of the dorsal and ventral surfaces of the wing blade (Brower and Jaffe, 1989). Null mutations cause embryonic lethality (Wilcox, DiAntonio and Leptin, 1989). In the mutant if1, the adult wing is inflated with lymph and smaller than normal; venation is defective. Wings later become dry and blistered.
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 63 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          FlyMine - An integrated database for Drosophila genomics
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          modMine - A data warehouse for the modENCODE project
          Synonyms and Secondary IDs (38)
          Reported As
          Symbol Synonym
          if
          (Camuglia et al., 2018, Lee et al., 2018, Park et al., 2018, Richier et al., 2018, Pérez-Moreno et al., 2017, Gene Disruption Project members, 2016-, Peters and Berg, 2016, Sandler and Stathopoulos, 2016, Maartens and Brown, 2015, Morozova et al., 2015, Ashwal-Fluss et al., 2014, DeSalvo et al., 2014, Kim and Choe, 2014, Kim et al., 2014, Meyer et al., 2014, Montgomery et al., 2014, Rembold et al., 2014, Weitkunat and Schnorrer, 2014, Brown et al., 2013.2.5, Ismat et al., 2013, Johnson et al., 2013, Lin et al., 2013, Liu et al., 2013, Nonaka et al., 2013, Pirraglia et al., 2013, Thimgan et al., 2013, Gates, 2012, Han et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Kim et al., 2012, Kókai et al., 2012, Ribeiro et al., 2011, Zervas et al., 2011, Cook et al., 2010, Fraichard et al., 2010, Gilsohn and Volk, 2010, Negreiros et al., 2010, Perkins et al., 2010, Popodi et al., 2010-, Tikhmyanova et al., 2010, Venken et al., 2010, Zhang et al., 2010, Christensen et al., 2009.2.28, Delon and Brown, 2009, Jattani et al., 2009, Liu et al., 2009, Chen et al., 2008, Christensen et al., 2008.9.3, Christensen et al., 2008.9.3, Christensen et al., 2008.9.3, Christensen et al., 2008.12.28, Dinkins et al., 2008, O'Reilly et al., 2008, Tsai et al., 2008, Zhang et al., 2008, Beltran et al., 2007, Chanana et al., 2007, Devenport et al., 2007, Dietzl et al., 2007, Estrada et al., 2007, Huang et al., 2007, Inoue and Hayashi, 2007, Junion et al., 2007, Ritzenthaler and Chiba, 2003)
          αPS2(ms8)
          αPS2
          (Park et al., 2018, Richier et al., 2018, Tang, 2017, Valdivia et al., 2017, Peters and Berg, 2016, Tavares et al., 2015, Wang et al., 2015, Dani et al., 2014, Xie et al., 2014, Ismat et al., 2013, Liu et al., 2013, Patel and Myat, 2013, Pirraglia et al., 2013, Bulgakova et al., 2012, Chountala et al., 2012, Gates, 2012, Han et al., 2012, Zhai et al., 2012, Egoz-Matia et al., 2011, Ellis et al., 2011, Pines et al., 2011, Urbano et al., 2011, Xie and Auld, 2011, Zervas et al., 2011, Fraichard et al., 2010, Delon and Brown, 2009, Jattani et al., 2009, Chen et al., 2008, Dinkins et al., 2008, Helsten et al., 2008, Loer et al., 2008, O'Reilly et al., 2008, Schotman et al., 2008, Devenport et al., 2007, Fernández-Miñán et al., 2007, Inoue and Hayashi, 2007, James et al., 2007, Jani and Schock, 2007, Nguyen et al., 2007, Takada et al., 2007, Tanentzapf et al., 2007, Lo, 2006, Tanentzapf and Brown, 2006, Tanentzapf et al., 2006, Bunch et al., 2004, Devenport and Brown, 2004, Grabbe et al., 2004, Abrams et al., 2003, Brower, 2003, Schock and Perrimon, 2003, Baker et al., 2002, Bokel and Brown, 2002, Jannuzi et al., 2002, Stevens and Jacobs, 2002, Bloor and Kiehart, 2001, Hughes, 2001, Zervas et al., 2001, Brown, 2000, Brown et al., 2000, D'Avino and Thummel, 2000, Hynes and Zhao, 2000, Kim and Chiba, 2000, Martin-Bermudo, 2000, Martin-Bermudo and Brown, 2000, Beumer et al., 1999, de Melker and Sonnenberg, 1999, Hoang and Chiba, 1998, Martin-Bermudo et al., 1998, Fleming et al., 1997, Martin-Bermudo et al., 1997, Prokop et al., 1996, Olson et al., 1995, Yarnitzky and Volk, 1995, Gotwals et al., 1994, Gotwals et al., 1994, Brown et al., 1993)
          αPS2 integrin
          Name Synonyms
          Integrin alphaPS2 subunit
          PS II alpha
          integrin PSI alpha subunit
          integrin αPS2 subunit
          position-specific antigen 2
          α2 integrin
          αPS2 integrin
          αPS2 Integrin
          αPS2-Integrin
          Secondary FlyBase IDs
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            References (340)