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Gene Dmel\if

General Information
Symbol	Dmel\if	Species	D. melanogaster
Name	inflated	Annotation symbol	CG9623
Feature type	protein_coding_gene	FlyBase ID	FBgn0001250
Gene Model Status	Current	Stock availability	11 publicly available
Also Known As	αPS2, αPS2, PS2, PS2α, PSα2, aPS2, PS 2
Genomic Location
Chromosome (arm)	X	Recombination map	1-55
Cytogenetic map	15A5-15A7	Sequence location	X:16,646,222..16,677,467 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene inflated is referred to in FlyBase by the symbol Dmel\if (CG9623, FBgn0001250). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: cell adhesion molecule binding; receptor activity. There is experimental evidence for 11 unique biological process terms, many of which group under: anatomical structure development; cellular component organization or biogenesis; biological regulation; organ development; sensory perception of smell; cell projection organization; gland morphogenesis; cellular component organization or biogenesis at cellular level; post-embryonic appendage morphogenesis; muscle organ development; cell adhesion; localization; regulation of developmental process. 82 alleles are reported. The phenotypes of these alleles are annotated with: hypodermal muscle of larval abdomen; organ system; organ system subdivision; adult segment; primordium; non-connected developing system; larval abdominal segment 5; presumptive embryonic/larval nervous system; larval abdominal segment; abdominal 7 longitudinal muscle. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: FG-GAP; Integrin alpha beta-propellor; Integrin alpha chain; Integrin alpha chain, C-terminal cytoplasmic region, conserved site; Integrin alpha-2. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 12-24 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult crop, larval/adult hindgut, larval Malpighian tubules, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1632744_a_at completely aligns to an exonic region common to each of the 4 FlyBase-annotated transcript isoforms of if. Gene sequence location is X:16646222..16677467.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	if: inflated Structural gene for the α-subunit of position specific integrin 2 (PS2), a large transmembrane protein (Bogaert et al., 1987). The β-subunit can associate with either of the two α-subunits, PS1 or PS2 (Brower et al., 1984; Wilcox, Brown, Piovant, Smith, and White, 1984, EMBO J. 3: 2307-13). Both α and β integrin are expressed in embryonic and larval tissues. In early development, PS2 is found in the mesoderm, localized to muscle attachments (Bogaert et al., 1987). Later, PS1 is expressed in the presumptive dorsal epithelium of the third instar imaginal wing discs; also, PS2 is found in the ventral epithelium, both integrins being important for the joining of the dorsal and ventral surfaces of the wing blade (Brower and Jaffe, 1989). Null mutations cause embryonic lethality (Wilcox, DiAntonio, and Leptin). In the mutant if1, the adult wing is inflated with lymph and smaller than normal; venation is defective. Wings later become dry and blistered. if3 Longitudinal veins thickened, especially at wing base. Anterior crossvein thickened. if3/if3 flies show reduced levels of PS2 integrin on the surfaces of some imaginal disc cells (especially in the ventral region), but levels of this integrin in muscle, salivary glands, and most other tissues seem to be normal (Brower and Jaffe, 1989). Adult wings typically show large round wing blisters, but the penetrance of this phenotype in homo- and hemizygotes is variable. if3/ifk27e flies show an increase in penetrance (from 15-20% in homozygotes to 60-70% in the heteroalleles); penetrance is reduced in if3/ifk27e flies by low temperature and crowding (Brower and Jaffe, 1989). ifN
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Perkins et al., 2010, Dev. Biol. 338(1): 15--27 Hughes, 2001, J. molec. Evol. 52(1): 63--72
FB2012_01	References Rui et al., 2010, PLoS Genet. 6(11): e1001208 Negreiros et al., 2010, genesis 48(1): 31--43 Sequence features BKN28544 HFA20341
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 15A5-15A7   Limits computationally determined from genome sequence between P{EP}EP1547EP1547 and P{EP}CG4928EP1341
Experimentally Determined Cytological Location
Cytogenetic map Notes References 15A1-15A5   (determined by in situ hybridisation)   (Bogaert et al., 1987)
Experimentally Determined Recombination Data
Location	1-55 (Curry, 1939)
Left of (cM)	f (Curry, 1939)
Right of (cM)	r (Wilcox et al., 1989, Green, 1997.8.18) un (Curry, 1939)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\if for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) if-RB FBtr0074357  NM_078654   5724   1396 if-RC FBtr0301352  NM_167544   5649   1371 if-RD FBtr0301353  NM_001169306   5633   1396 if-RF FBtr0301354  NM_001169307   5818   1396
Additional Transcript Data & Comments
Reported size (kB)	5.7 (northern blot) (Bogaert et al., 1987)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein if-PB   FBpp0074131   154.3   1396   6.10     NP_523378   AAF48661 if-PC   FBpp0290566   151.6   1371   6.04     NP_728021   AAN09423 if-PD   FBpp0290567   154.3   1396   6.10     NP_001162777   ACZ95312 if-PF   FBpp0290568   154.3   1396   6.10     NP_001162778   ACZ95313
Additional Polypeptide Data & Comments
Reported size (kDa)	1394 (aa); 140 (kD observed) (Bogaert et al., 1987)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Integrin alpha chain, C-terminal cytoplasmic region, conserved site (IPR018184) Integrin alpha chain (IPR000413) Integrin alpha beta-propellor (IPR013519) Integrin alpha-2 (IPR013649) FG-GAP (IPR013517)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA141822   AA141823   AA803975   AE014298 AAF48661   AE014298 AAN09423   AE014298 ACZ95312   AE014298 ACZ95313   AY118840 AAM50700   BF494222   BT025044   CO186660   CO264090   CO264203   CO265925   CO270351   CO276570   CO277996   CO284320   CO285448   CO291655   CO292632   CO294770   CO295924   CO298379   CO305426   CO340643   CO341448   EC051283   EC051778   EC051786   EC055462   EC055912   EC056118   EC061061   EC065918   EC073636   EC074966   EC077350   EC083073   EC083790   EC084359   EC085560   EC194667   EC194872   EC198420   EC209666   EC222648   EC224126   EC243314   EC247472   EC255869   EL885330   EL885331   EL885370   EL885371   EL885406   EL885407   M19059 AAC12788
UniProtKB/Swiss-Prot	P12080
UniProtKB/TrEMBL	Q8IR07 Q8MSG3 E1JJN2
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
radioisotope in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 4 -- 13   mesoderm   (Bogaert et al., 1987) third instar larval stage   peripodial epithelium   (Bogaert et al., 1987) wing disc   (Bogaert et al., 1987)
Additional Descriptive Data
	if transcripts are expressed throughout development and in adults. In embryos, they are first detected at stage 4 in the presumptive mesoderm. They continue to be expressed in mesodermal cells after invagination. In third instar larval wing discs, if transcripts are primarily restricted to the ventral compartment and to the peripodial membrane. (Bogaert et al., 1987)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   gonadal sheath muscle   (Bogaert et al., 1987) visceral mesoderm   (Bogaert et al., 1987) muscle attachment site   (Bogaert et al., 1987) pharyngeal muscle   (Bogaert et al., 1987) gonad | restricted   (Bogaert et al., 1987) embryonic stage 10 -- 17   mesoderm   (Bogaert et al., 1987) embryonic stage 16   muscle attachment site   (Bloor and Kiehart, 2001) third instar larval stage   wing disc   (Bogaert et al., 1987) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
	if protein is first detected in stage 10 embryos in the mesoderm where it is basally concentrated in cuboidal cells which lie on the ectoderm. After the somatic and visceral mesoderm separates, if protein is found on the basal cell surfaces of the visceral myoblasts when they attach to the foregut, midgut, and hindgut. It is also found at the sites of attachment of the somatic muscles. Protein was also detected in the gonadal sheath and in the interstitial cells of the gonad In third instar larval wing discs, if protein is primarily restricted to the ventral compartment. (Bogaert et al., 1987)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0001250    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0001250 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 12-24 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0001250 expression level Developmental Stage   Expression Level embryo 00-02hr    41 embryo 02-04hr    466 embryo 04-06hr    923 embryo 06-08hr    982 embryo 08-10hr    936 embryo 10-12hr    1385 embryo 12-14hr    1921 embryo 14-16hr    3469 embryo 16-18hr    5422 embryo 18-20hr    8975 embryo 20-22hr    4759 embryo 22-24hr    4637 larva L1    2201 larva L2    1758 larva L3 12hr old    2479 larva L3 puffstage 1-2    1119 larva L3 puffstage 3-6    1412 larva L3 puffstage 7-9    1181 white prepupae new    976 white prepupae 12hr    1031 white prepupae 24hr    998 pupae 2d postWPP    1262 pupae 3d postWPP    3778 pupae 4d postWPP    2745 adult male 01day    2121 adult male 05day    1841 adult male 30day    1654 adult female 01day    1307 adult female 05day    493 adult female 30day    511 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    41 embryo 02-04hr  (466) embryo 04-06hr  (923) embryo 06-08hr  (982) embryo 08-10hr  (936) embryo 10-12hr  (1385) embryo 12-14hr  (1921) embryo 14-16hr  (3469) embryo 16-18hr  (5422) embryo 18-20hr  (8975) embryo 20-22hr  (4759) embryo 22-24hr  (4637) larva L1  (2201) larva L2  (1758) larva L3 12hr old  (2479) larva L3 puffstage 1-2  (1119) larva L3 puffstage 3-6  (1412) larva L3 puffstage 7-9  (1181) white prepupae new  (976) white prepupae 12hr  (1031) white prepupae 24hr  (998) pupae 2d postWPP  (1262) pupae 3d postWPP  (3778) pupae 4d postWPP  (2745) adult male 01day  (2121) adult male 05day  (1841) adult male 30day  (1654) adult female 01day  (1307) adult female 05day  (493) adult female 30day  (511) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    41 embryo 02-04hr    466 embryo 04-06hr    923 embryo 06-08hr    982 embryo 08-10hr    936 embryo 10-12hr    1385 embryo 12-14hr  (1921) embryo 14-16hr  (3469) embryo 16-18hr  (5422) embryo 18-20hr  (8975) embryo 20-22hr  (4759) embryo 22-24hr  (4637) larva L1  (2201) larva L2  (1758) larva L3 12hr old  (2479) larva L3 puffstage 1-2    1119 larva L3 puffstage 3-6  1412 larva L3 puffstage 7-9    1181 white prepupae new    976 white prepupae 12hr    1031 white prepupae 24hr    998 pupae 2d postWPP    1262 pupae 3d postWPP  (3778) pupae 4d postWPP  (2745) adult male 01day  (2121) adult male 05day  (1841) adult male 30day  (1654) adult female 01day    1307 adult female 05day    493 adult female 30day    511 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    41 embryo 02-04hr    466 embryo 04-06hr    923 embryo 06-08hr    982 embryo 08-10hr    936 embryo 10-12hr    1385 embryo 12-14hr    1921 embryo 14-16hr    3469 embryo 16-18hr    5422 embryo 18-20hr    8975 embryo 20-22hr    4759 embryo 22-24hr    4637 larva L1    2201 larva L2    1758 larva L3 12hr old    2479 larva L3 puffstage 1-2    1119 larva L3 puffstage 3-6    1412 larva L3 puffstage 7-9    1181 white prepupae new    976 white prepupae 12hr    1031 white prepupae 24hr    998 pupae 2d postWPP    1262 pupae 3d postWPP    3778 pupae 4d postWPP    2745 adult male 01day    2121 adult male 05day    1841 adult male 30day    1654 adult female 01day    1307 adult female 05day    493 adult female 30day    511 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    41 embryo 02-04hr    466 embryo 04-06hr    923 embryo 06-08hr    982 embryo 08-10hr    936 embryo 10-12hr    1385 embryo 12-14hr    1921 embryo 14-16hr    3469 embryo 16-18hr    5422 embryo 18-20hr    8975 embryo 20-22hr    4759 embryo 22-24hr    4637 larva L1    2201 larva L2    1758 larva L3 12hr old    2479 larva L3 puffstage 1-2    1119 larva L3 puffstage 3-6    1412 larva L3 puffstage 7-9    1181 white prepupae new    976 white prepupae 12hr    1031 white prepupae 24hr    998 pupae 2d postWPP    1262 pupae 3d postWPP    3778 pupae 4d postWPP    2745 adult male 01day    2121 adult male 05day    1841 adult male 30day    1654 adult female 01day    1307 adult female 05day    493 adult female 30day    511 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0001250 expression level Developmental Stage   Expression Level embryo 00-02hr    41 embryo 02-04hr    466 embryo 04-06hr    923 embryo 06-08hr    982 embryo 08-10hr    936 embryo 10-12hr    1385 embryo 12-14hr    1921 embryo 14-16hr    3469 embryo 16-18hr    5422 embryo 18-20hr    8975 embryo 20-22hr    4759 embryo 22-24hr    4637 larva L1    2201 larva L2    1758 larva L3 12hr old    2479 larva L3 puffstage 1-2    1119 larva L3 puffstage 3-6    1412 larva L3 puffstage 7-9    1181 white prepupae new    976 white prepupae 12hr    1031 white prepupae 24hr    998 pupae 2d postWPP    1262 pupae 3d postWPP    3778 pupae 4d postWPP    2745 adult male 01day    2121 adult male 05day    1841 adult male 30day    1654 adult female 01day    1307 adult female 05day    493 adult female 30day    511 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    41 embryo 02-04hr  (466) embryo 04-06hr  (923) embryo 06-08hr  (982) embryo 08-10hr  (936) embryo 10-12hr  (1385) embryo 12-14hr  (1921) embryo 14-16hr  (3469) embryo 16-18hr  (5422) embryo 18-20hr  (8975) embryo 20-22hr  (4759) embryo 22-24hr  (4637) larva L1  (2201) larva L2  (1758) larva L3 12hr old  (2479) larva L3 puffstage 1-2  (1119) larva L3 puffstage 3-6  (1412) larva L3 puffstage 7-9  (1181) white prepupae new  (976) white prepupae 12hr  (1031) white prepupae 24hr  (998) pupae 2d postWPP  (1262) pupae 3d postWPP  (3778) pupae 4d postWPP  (2745) adult male 01day  (2121) adult male 05day  (1841) adult male 30day  (1654) adult female 01day  (1307) adult female 05day  (493) adult female 30day  (511) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    41 embryo 02-04hr    466 embryo 04-06hr    923 embryo 06-08hr    982 embryo 08-10hr    936 embryo 10-12hr    1385 embryo 12-14hr  1921 embryo 14-16hr  (3469) embryo 16-18hr  (5422) embryo 18-20hr  (8975) embryo 20-22hr  (4759) embryo 22-24hr  (4637) larva L1  2201 larva L2  1758 larva L3 12hr old  (2479) larva L3 puffstage 1-2    1119 larva L3 puffstage 3-6  1412 larva L3 puffstage 7-9    1181 white prepupae new    976 white prepupae 12hr    1031 white prepupae 24hr    998 pupae 2d postWPP    1262 pupae 3d postWPP  (3778) pupae 4d postWPP  (2745) adult male 01day  2121 adult male 05day  1841 adult male 30day  1654 adult female 01day    1307 adult female 05day    493 adult female 30day    511 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    41 embryo 02-04hr    466 embryo 04-06hr    923 embryo 06-08hr    982 embryo 08-10hr    936 embryo 10-12hr    1385 embryo 12-14hr    1921 embryo 14-16hr    3469 embryo 16-18hr    5422 embryo 18-20hr    8975 embryo 20-22hr    4759 embryo 22-24hr    4637 larva L1    2201 larva L2    1758 larva L3 12hr old    2479 larva L3 puffstage 1-2    1119 larva L3 puffstage 3-6    1412 larva L3 puffstage 7-9    1181 white prepupae new    976 white prepupae 12hr    1031 white prepupae 24hr    998 pupae 2d postWPP    1262 pupae 3d postWPP    3778 pupae 4d postWPP    2745 adult male 01day    2121 adult male 05day    1841 adult male 30day    1654 adult female 01day    1307 adult female 05day    493 adult female 30day    511 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    41 embryo 02-04hr    466 embryo 04-06hr    923 embryo 06-08hr    982 embryo 08-10hr    936 embryo 10-12hr    1385 embryo 12-14hr    1921 embryo 14-16hr    3469 embryo 16-18hr    5422 embryo 18-20hr    8975 embryo 20-22hr    4759 embryo 22-24hr    4637 larva L1    2201 larva L2    1758 larva L3 12hr old    2479 larva L3 puffstage 1-2    1119 larva L3 puffstage 3-6    1412 larva L3 puffstage 7-9    1181 white prepupae new    976 white prepupae 12hr    1031 white prepupae 24hr    998 pupae 2d postWPP    1262 pupae 3d postWPP    3778 pupae 4d postWPP    2745 adult male 01day    2121 adult male 05day    1841 adult male 30day    1654 adult female 01day    1307 adult female 05day    493 adult female 30day    511 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0001250    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0001250 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult crop, larval/adult hindgut, larval Malpighian tubules, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0001250 expression level Tissue   Expression Level Larval Central Nervous System    145.2 Larval Midgut    85.8 Larval Hindgut    554.4 Larval Malpighian Tubules    1185.7 Larval Fat Body no informative data Larval Salivary Gland    493.2 Larval Trachea    349.45 Larval Carcass    991.75 Adult Head    204.7 Adult Eye    68.375 Adult Brain    78.5 Adult Thoracic-Abdominal Ganglion    117.7 Adult Crop    925.1 Adult Midgut    87.8 Adult Hindgut    579.7 Adult Malpighian Tubules    300.7 Adult Fat Body    160.3 Adult Salivary Gland    183.6 Adult Heart    255.675 Adult VirginFemale Spermatheca    234.7 Adult InseminatedFemale Spermatheca    193.6 Adult Ovary    21.5 Adult Testis    34.5 Adult Male Accessory Gland    96.7 Adult Carcass    280.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    145.2 Larval Midgut    85.8 Larval Hindgut  (554.4) Larval Malpighian Tubules  (1185.7) Larval Fat Body no informative data Larval Salivary Gland    493.2 Larval Trachea    349.45 Larval Carcass  (991.75) Adult Head    204.7 Adult Eye    68.375 Adult Brain    78.5 Adult Thoracic-Abdominal Ganglion    117.7 Adult Crop  (925.1) Adult Midgut    87.8 Adult Hindgut  (579.7) Adult Malpighian Tubules    300.7 Adult Fat Body    160.3 Adult Salivary Gland    183.6 Adult Heart    255.675 Adult VirginFemale Spermatheca    234.7 Adult InseminatedFemale Spermatheca    193.6 Adult Ovary    21.5 Adult Testis    34.5 Adult Male Accessory Gland    96.7 Adult Carcass    280.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    145.2 Larval Midgut    85.8 Larval Hindgut    554.4 Larval Malpighian Tubules  (1185.7) Larval Fat Body no informative data Larval Salivary Gland    493.2 Larval Trachea    349.45 Larval Carcass    991.75 Adult Head    204.7 Adult Eye    68.375 Adult Brain    78.5 Adult Thoracic-Abdominal Ganglion    117.7 Adult Crop    925.1 Adult Midgut    87.8 Adult Hindgut    579.7 Adult Malpighian Tubules    300.7 Adult Fat Body    160.3 Adult Salivary Gland    183.6 Adult Heart    255.675 Adult VirginFemale Spermatheca    234.7 Adult InseminatedFemale Spermatheca    193.6 Adult Ovary    21.5 Adult Testis    34.5 Adult Male Accessory Gland    96.7 Adult Carcass    280.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    145.2 Larval Midgut    85.8 Larval Hindgut    554.4 Larval Malpighian Tubules    1185.7 Larval Fat Body no informative data Larval Salivary Gland    493.2 Larval Trachea    349.45 Larval Carcass    991.75 Adult Head    204.7 Adult Eye    68.375 Adult Brain    78.5 Adult Thoracic-Abdominal Ganglion    117.7 Adult Crop    925.1 Adult Midgut    87.8 Adult Hindgut    579.7 Adult Malpighian Tubules    300.7 Adult Fat Body    160.3 Adult Salivary Gland    183.6 Adult Heart    255.675 Adult VirginFemale Spermatheca    234.7 Adult InseminatedFemale Spermatheca    193.6 Adult Ovary    21.5 Adult Testis    34.5 Adult Male Accessory Gland    96.7 Adult Carcass    280.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0001250 expression level Tissue   Expression Level Larval Central Nervous System    145.2 Larval Midgut    85.8 Larval Hindgut    554.4 Larval Malpighian Tubules    1185.7 Larval Fat Body no informative data Larval Salivary Gland    493.2 Larval Trachea    349.45 Larval Carcass    991.75 Adult Head    204.7 Adult Eye    68.375 Adult Brain    78.5 Adult Thoracic-Abdominal Ganglion    117.7 Adult Crop    925.1 Adult Midgut    87.8 Adult Hindgut    579.7 Adult Malpighian Tubules    300.7 Adult Fat Body    160.3 Adult Salivary Gland    183.6 Adult Heart    255.675 Adult VirginFemale Spermatheca    234.7 Adult InseminatedFemale Spermatheca    193.6 Adult Ovary    21.5 Adult Testis    34.5 Adult Male Accessory Gland    96.7 Adult Carcass    280.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    145.2 Larval Midgut    85.8 Larval Hindgut  554.4 Larval Malpighian Tubules  (1185.7) Larval Fat Body no informative data Larval Salivary Gland    493.2 Larval Trachea    349.45 Larval Carcass  (991.75) Adult Head    204.7 Adult Eye    68.375 Adult Brain    78.5 Adult Thoracic-Abdominal Ganglion    117.7 Adult Crop  (925.1) Adult Midgut    87.8 Adult Hindgut  579.7 Adult Malpighian Tubules    300.7 Adult Fat Body    160.3 Adult Salivary Gland    183.6 Adult Heart    255.675 Adult VirginFemale Spermatheca    234.7 Adult InseminatedFemale Spermatheca    193.6 Adult Ovary    21.5 Adult Testis    34.5 Adult Male Accessory Gland    96.7 Adult Carcass    280.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    145.2 Larval Midgut    85.8 Larval Hindgut    554.4 Larval Malpighian Tubules  1185.7 Larval Fat Body no informative data Larval Salivary Gland    493.2 Larval Trachea    349.45 Larval Carcass    991.75 Adult Head    204.7 Adult Eye    68.375 Adult Brain    78.5 Adult Thoracic-Abdominal Ganglion    117.7 Adult Crop    925.1 Adult Midgut    87.8 Adult Hindgut    579.7 Adult Malpighian Tubules    300.7 Adult Fat Body    160.3 Adult Salivary Gland    183.6 Adult Heart    255.675 Adult VirginFemale Spermatheca    234.7 Adult InseminatedFemale Spermatheca    193.6 Adult Ovary    21.5 Adult Testis    34.5 Adult Male Accessory Gland    96.7 Adult Carcass    280.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    145.2 Larval Midgut    85.8 Larval Hindgut    554.4 Larval Malpighian Tubules    1185.7 Larval Fat Body no informative data Larval Salivary Gland    493.2 Larval Trachea    349.45 Larval Carcass    991.75 Adult Head    204.7 Adult Eye    68.375 Adult Brain    78.5 Adult Thoracic-Abdominal Ganglion    117.7 Adult Crop    925.1 Adult Midgut    87.8 Adult Hindgut    579.7 Adult Malpighian Tubules    300.7 Adult Fat Body    160.3 Adult Salivary Gland    183.6 Adult Heart    255.675 Adult VirginFemale Spermatheca    234.7 Adult InseminatedFemale Spermatheca    193.6 Adult Ovary    21.5 Adult Testis    34.5 Adult Male Accessory Gland    96.7 Adult Carcass    280.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    204.7   NA  Eye    68.375   NA  Brain    78.5   145.2  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    117.7   NA  Crop    925.1   85.8  Midgut    87.8   554.4  Hindgut    579.7   1185.7  Malpighian Tubules    300.7   no informative data  Fat Body    160.3   493.2  Salivary Gland    183.6   NA  Heart    255.675   349.45  Trachea    NA   NA  VirginFemale Spermatheca    234.7   NA  InseminatedFemale Spermatheca    193.6   NA  Ovary    21.5   NA  Testis    34.5   NA  Male Accessory Gland    96.7   991.75  Carcass    280.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_29
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001250 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9623-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal ifB2 ifk27e lethal, with Scer\GAL4elav.PLu ifGD1175 lethal, with Scer\GAL4Mef2.PR ifGD1175 lethal | embryonic stage ifB2 ifB4 ifk27e lethal | embryonic stage | recessive if2B2 if2B3 if4.5 if6 if8 if9 if13ts if16 if17 if21 if26 if35 if38 if64 if648 ifA2 ifA7 ifB2 ifB4 ifB6 ifC1A ifC3C ifC4D ifC5E ifK13 ifK23 ifk27e ifL6 ifL10 ifL13 ifM2 ifN18R ifN19S ifO2 ifO2B ifO9I ifO11K ifO17Q ifQ2B ifSEF lethal | pupal stage, with Scer\GAL4pnr-MD237 ifGD1175 lethal | recessive if2B1 ifB2 ifC2B ifH18 ifK13 ifk27e semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 ifGD1175 viable if1 if3 ifN viable (with if2B1) ifSEF viable (with ifC2B) ifSEF viable (with ifSEF) if2B1 ifC2B viable | poor if1 Sterility Allele fertile if3 ifN fertile | poor if1 Other Phenotypes Allele neuroanatomy defective ifk27e visible if1 if3 ifm8.αTub84B ifN visible | dominant if2B1 if6 if8 if26 if64 if648 ifB4 ifC2B ifK13 ifK23 ifL6 ifL10 ifL326 visible | heat sensitive, with Scer\GAL4337Y ifGOF.m8.Scer\UAS ifLOF.m8.Scer\UAS ifm8.Scer\UAS visible | recessive if3 visible | recessive | cold sensitive if3 wild-type if+t39 if+tBa ifminigene Phenotype manifest in Allele abdominal 2 lateral longitudinal muscle 1 ifB4 abdominal 2 segment border muscle ifB4 abdominal 2 ventral longitudinal muscle 1 ifB4 abdominal 3 lateral longitudinal muscle 1 ifB4 abdominal 3 segment border muscle ifB4 abdominal 3 ventral longitudinal muscle 1 ifB4 abdominal 4 lateral longitudinal muscle 1 ifB4 abdominal 4 segment border muscle ifB4 abdominal 4 ventral longitudinal muscle 1 ifB4 abdominal 5 lateral longitudinal muscle 1 ifB4 abdominal 5 segment border muscle ifB4 abdominal 5 ventral longitudinal muscle 1 ifB4 abdominal 6 lateral longitudinal muscle 1 ifB4 abdominal 6 segment border muscle ifB4 abdominal 6 ventral longitudinal muscle 1 ifB4 abdominal 7 lateral longitudinal muscle 1 ifB4 abdominal 7 segment border muscle ifB4 abdominal 7 ventral longitudinal muscle 1 ifB4 actin cytoskeleton | embryonic stage 17 if17 if21 if35 ifSEF anterior crossvein if3 anterior midgut primordium if13ts if16 if17 if21 if26 if2B2 if2B3 if35 if38 if4.5 if6 if64 if648 if8 if9 ifA2 ifA7 ifB2 ifB4 ifB6 ifC1A ifC3C ifC4D ifC5E ifK13 ifK23 ifL10 ifL13 ifL326 ifL6 ifM2 ifN18R ifN19S ifO11K ifO17Q ifO2 ifO2B ifO9I ifQ2B ifk27e crossvein if3 ifN embryonic/first instar larval cuticle | dorsal ifB4 ifk27e embryonic/larval midgut if2B1 ifC2B embryonic/larval midgut | embryonic stage if2B1 ifA7 ifB2 ifB4 ifC2B ifk27e embryonic/larval proventriculus | embryonic stage ifB4 embryonic/larval somatic muscle if13ts if16 if17 if21 if26 if2B2 if2B3 if35 if38 if4.5 if6 if64 if648 if8 if9 ifA2 ifA7 ifB2 ifB4 ifB6 ifC1A ifC2B ifC3C ifC4D ifC5E ifK13 ifK23 ifL10 ifL13 ifL326 ifL6 ifM2 ifN18R ifN19S ifO11K ifO17Q ifO2 ifO2B ifO9I ifQ2B ifk27e embryonic/larval somatic muscle | embryonic stage 17 if17 if21 if35 ifSEF embryonic/larval visceral branch ifB4 embryonic/larval visceral muscle if17 ifB4 ifC2B extended germ band embryo ifB4 ifk27e eye, with Scer\GAL4how-24B ifC.Scer\UAS filopodium & abdominal ventral longitudinal muscle 3 ifk27e gastric caecum if13ts if16 if17 if21 if26 if2B2 if2B3 if35 if38 if4.5 if6 if64 if648 if8 if9 ifA2 ifA7 ifB2 ifB4 ifB6 ifC1A ifC3C ifC4D ifC5E ifK13 ifK23 ifL10 ifL13 ifL326 ifL6 ifM2 ifN18R ifN19S ifO11K ifO17Q ifO2 ifO2B ifO9I ifQ2B ifk27e gastric caecum primordium if13ts if16 if17 if21 if26 if2B2 if2B3 if35 if38 if4.5 if6 if64 if648 if8 if9 ifA2 ifA7 ifB2 ifB4 ifB6 ifC1A ifC2B ifC3C ifC4D ifC5E ifK13 ifK23 ifL10 ifL13 ifL326 ifL6 ifM2 ifN18R ifN19S ifO11K ifO17Q ifO2 ifO2B ifO9I ifQ2B ifk27e germ layer | embryonic stage ifk27e hemocyte | embryonic stage ifB2 intersegmental nerve ifk27e midgut constriction ifB4 ifk27e muscle attachment site ifC2B muscle attachment site & basal lamina ifB4 muscle attachment site & connecting hemi-adherens junction ifB4 muscle attachment site & muscle tendon junction ifB4 muscle attachment site | embryonic stage ifB2 presumptive embryonic/larval central nervous system ifB2 ifk27e presumptive embryonic/larval digestive system ifB4 presumptive embryonic/larval muscle system ifSEF presumptive embryonic/larval peripheral nervous system ifB2 ifk27e presumptive embryonic salivary gland ifk27e proventriculus inner layer ifB4 RP3 neuron ifk27e salivary gland common duct primordium ifB4 ifk27e sarcomere & somatic muscle if13ts if17 if21 if35 ifSEF segmental nerve ifk27e somatic muscle ifB4 ifSEF ifk27e somatic muscle | larval stage if2B1 stage S14 oocyte ifB2 ventral nerve cord if13ts if16 if17 if21 if26 if2B1 if2B2 if2B3 if35 if38 if4.5 if6 if64 if648 if8 if9 ifA2 ifA7 ifB2 ifB4 ifB6 ifC1A ifC3C ifC4D ifC5E ifK13 ifK23 ifL10 ifL13 ifL326 ifL6 ifM2 ifN18R ifN19S ifO11K ifO17Q ifO2 ifO2B ifO9I ifQ2B ifSEF ifk27e visceral mesoderm ifB4 ifk27e wing if1 if26 if2B1 if3 if6 if64 if648 if8 ifB4 ifC2B ifK13 ifK23 ifL10 ifL326 ifL6 ifN ifk27e ifm8.αTub84B wing, with Scer\GAL4684 ifm8.Scer\UAS wing | cold sensitive if3 wing | heat sensitive, with Scer\GAL4337Y ifGOF.m8.Scer\UAS ifLOF.m8.Scer\UAS ifm8.Scer\UAS wing | somatic clone ifA7 wing blade if3 wing vein if1 if3 ifN
Classical Alleles ( 54 )
For All Classical Alleles Show
Allele of if Class Mutagen Stocks Known lesion ifB2 loss of function allele, amorphic allele - genetic evidence, hypomorphic allele - genetic evidence ethyl methanesulfonate 2 -- ifk27e amorphic allele - genetic evidence, loss of function allele ethyl methanesulfonate 2 -- if3 hypomorphic allele - genetic evidence spontaneous 2 -- ifMB10541 1 -- if16 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- if26 amorphic allele - genetic evidence X ray 0 -- if2B2 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- if2B3 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- if38 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- if4.5 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- if648 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- if64 amorphic allele - genetic evidence X ray 0 -- if6 amorphic allele - genetic evidence X ray 0 -- if8 amorphic allele - genetic evidence X ray 0 -- if9 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- ifA2 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- ifA7 loss of function allele, amorphic allele - genetic evidence ethyl methanesulfonate 0 -- ifB4 loss of function allele, amorphic allele - genetic evidence gamma ray 0 Yes ifB6 amorphic allele - genetic evidence gamma ray 0 Yes ifC1A amorphic allele - genetic evidence ethyl nitrosourea 0 -- ifC3C amorphic allele - genetic evidence ethyl nitrosourea 0 -- ifC4D amorphic allele - genetic evidence ethyl methanesulfonate 0 -- ifC5E amorphic allele - genetic evidence ethyl methanesulfonate 0 -- ifK13 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- ifK23 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- ifL10 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- ifL13 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- ifL326 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- ifL6 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- ifM2 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- ifN18R amorphic allele - genetic evidence ethyl methanesulfonate 0 -- ifN19S amorphic allele - genetic evidence ethyl methanesulfonate 0 -- ifO11K amorphic allele - genetic evidence ethyl methanesulfonate 0 -- ifO17Q amorphic allele - genetic evidence ethyl methanesulfonate 0 -- ifO2 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- ifO2B amorphic allele - genetic evidence ethyl methanesulfonate 0 -- ifO9I amorphic allele - genetic evidence ethyl methanesulfonate 0 -- ifQ2B amorphic allele - genetic evidence ethyl methanesulfonate 0 -- if13ts hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- if17 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes if1 spontaneous 0 -- if21 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes if2 0 -- if2B1 ethyl methanesulfonate 0 Yes if35 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes if815-17 X ray 0 -- ifB2.1 gamma ray 0 -- ifC2B ethyl nitrosourea 0 Yes ifCPTI004152 piggyBac transposase 0 Yes ifGG01583 0 -- ifH18 0 -- ifN neutrons 0 -- ifSEF ethyl methanesulfonate 0 Yes ifunspecified 0 --
Alleles Carried on Transgenic Constructs ( 28 )
For All Alleles Carried on Transgenic Constructs Show
Allele of if Class Mutagen Stocks Known lesion ifGD1175 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes ifJF02695 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ifKK108544 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes if+t39 in vitro construct - genomic fragment 0 Yes if+tBa in vitro construct - deletion 0 Yes ifC.hs in vitro construct - regulatory fusion 0 Yes ifC.Scer\UAS in vitro construct - regulatory fusion 0 Yes ifGFANA.hs in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes ifGOF.C.hs in vitro construct - deletion 0 Yes ifGOF.m8.hs in vitro construct - deletion 0 Yes ifGOF.m8.Scer\UAS in vitro construct - deletion 0 Yes ifLOF.C.hs in vitro construct - amino acid replacement 0 Yes ifLOF.m8.hs in vitro construct - amino acid replacement 0 Yes ifLOF.m8.Scer\UAS in vitro construct - amino acid replacement 0 Yes ifm8.hs in vitro construct - regulatory fusion 0 Yes ifm8.Scer\FRT.αTub84B in vitro construct - regulatory fusion 0 Yes ifm8.Scer\UAS in vitro construct - regulatory fusion 0 Yes ifm8.αTub84B FLPase 0 Yes ifminigene in vitro construct - deletion 0 Yes ifMtnA.PG in vitro construct - regulatory fusion 0 Yes ifScer\UAS.cMBa in vitro construct - regulatory fusion 0 Yes ifΔ.C.hs in vitro construct - deletion 0 Yes ifΔ.C.Scer\UAS in vitro construct - deletion 0 Yes ifΔ.m8.hs in vitro construct - deletion 0 Yes ifΔ.m8.Scer\UAS in vitro construct - deletion 0 Yes ifΔcyt.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes ifΔGFFNR.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes ifΔGFFNR in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Ab(1;?)ifB2.1 (Brown, 1994) Df(1)BSC581 (Christensen et al., 2008.9.3) Df(1)BSC582 (Christensen et al., 2008.9.3) Df(1)BSC593 (Christensen et al., 2008.9.3) Df(1)BSC725 (Christensen et al., 2008.12.28) Df(1)BSC762 (Christensen et al., 2009.2.28) Df(1)ED7374 (Roote, 2004.6.24, Ryder and Roote, 2004.11.10) Df(1)r-D1 (Schalet, 1986) Df(1)rif (Bloor and Brown, 1998, Walsh and Brown, 1998, Brown, 1994) T(1;2)ifB6 (Brown, 1994) T(1;4)ifV2 (Brown, 1994)
Duplicated in	Dp(1;3)DC319 (Popodi et al., 2010-) Dp(1;4)80f3c (Bloor and Brown, 1998) Dp(1;4)fK4 (McKim et al., 1996) Dp(1;4)fK7 (McKim et al., 1996) Dp(1;4)fK24 (McKim et al., 1996) Dp(1;4)fK27 (McKim et al., 1996) Dp(1;4)r+l (McKim et al., 1996)
Not disrupted in	Df(1)815-6 (McKim et al., 1996) Df(1)B (McKim et al., 1996) Df(1)BK8 (McKim et al., 1996) Df(1)BK10 (McKim et al., 1996) Df(1)BK16 (McKim et al., 1996) Df(1)BK17 (McKim et al., 1996) Df(1)BK18 (McKim et al., 1996) Df(1)BK28 (McKim et al., 1996) T(1;4)ifV2 (Bloor and Brown, 1998)
Not duplicated in	Dp(1;3)f+71b (McKim et al., 1996) Dp(1;4)rK20 (McKim et al., 1996) Dp(1;Y)W73 (McKim et al., 1996)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1175} NA P{KK108544} NA P{TRiP.JF02695} NA P{UAS-if::mew.αPS1/2} NA P{UAS-if::mew.αPS2/1} NA P{UAS-if.c/g} NA P{UAS-if.C.Δ} NA P{UAS-if.C} NA P{UAS-if.GOF.m8} NA P{UAS-if.LOF.m8} NA P{UAS-if.m8.Δ} NA P{UAS-if.m8} NA P{UAS-if.Δcyt} NA P{UAS-if.ΔGFFNR} NA reporter construct P{if-lacZ.CRM} No P{if-lacZ.J} No P{if-lacZ.L} No P{αPS2lacZ} No characterization construct P{if.midigene} NA P{if.minigene} NA P{if.ΔGFFNR} NA P{if+RR1PS2} NA P{αTub84B(FRT.y+)if.m8} NA P{αTub84B(-FRT)if.m8} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{Mae-UAS.6.11}ifGG01583 NA insertion of enhancer trap binary system Mi{ET1}ifMB10541 No miscellaneous insertions PBac{806.LOX-SVS-2}ifCPTI004152 NA
Gene Ontology: Function, Process & Cellular Component ( 26 unique terms )
Terms Based on Experimental Evidence ( 16 terms )
Molecular Function
CV term Evidence References
cell adhesion molecule binding inferred from direct assay (Bogaert et al., 1987) receptor activity inferred from direct assay (Bogaert et al., 1987)
Biological Process
CV term Evidence References
axonal defasciculation inferred from mutant phenotype (Huang et al., 2007) axon guidance inferred from mutant phenotype (Stevens and Jacobs, 2002) cell adhesion inferred from direct assay (Bogaert et al., 1987) inferred from mutant phenotype (Kiger et al., 2003) imaginal disc-derived wing morphogenesis inferred from expression pattern AND inferred from mutant phenotype (Brabant et al., 1996) maintenance of epithelial integrity, open tracheal system inferred from genetic interaction with mys (Levi et al., 2006) maintenance of protein location inferred from mutant phenotype (Bloor and Kiehart, 2001) muscle attachment inferred from genetic interaction with Grip (Estrada et al., 2007) inferred from mutant phenotype (Bloor and Kiehart, 2001, Devenport et al., 2007) myofibril assembly inferred from mutant phenotype (Bloor and Kiehart, 2001) regulation of cell shape inferred from mutant phenotype (Kiger et al., 2003) salivary gland morphogenesis inferred from genetic interaction with βTub85D (Jattani et al., 2009) sensory perception of smell inferred from genetic interaction with sws (Ayyub and Paranjape, 2002)
Cellular Component
CV term Evidence References
contractile fiber inferred from direct assay (Bloor and Kiehart, 2001) cytoplasm inferred from direct assay (Tanentzapf et al., 2006) nucleus inferred from direct assay (Tanentzapf et al., 2006)
Terms Based on Predictions or Assertions ( 13 terms )
Molecular Function
CV term Evidence References
cell adhesion molecule binding inferred from sequence or structural similarity (Hynes and Zhao, 2000) receptor activity inferred from sequence or structural similarity (Hynes and Zhao, 2000)
Biological Process
CV term Evidence References
apposition of dorsal and ventral imaginal disc-derived wing surfaces non-traceable author statement (Brower, 2003) cell-cell adhesion traceable author statement (Brown, 2000) cell-matrix adhesion inferred from sequence or structural similarity (Hynes and Zhao, 2000) cell migration traceable author statement (Brown, 2000) epithelial cell migration, open tracheal system traceable author statement (Rosin and Shilo, 2002) heterophilic cell-cell adhesion traceable author statement (Hynes and Zhao, 2000) imaginal disc-derived wing morphogenesis traceable author statement (Brown, 2000) midgut development traceable author statement (Brown, 2000) salivary gland development traceable author statement (Abrams et al., 2003) tracheal outgrowth, open tracheal system traceable author statement (Ghabrial et al., 2003)
Cellular Component
CV term Evidence References
integrin complex inferred from electronic annotation with InterPro:IPR000413 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Hynes and Zhao, 2000) non-traceable author statement (Brower, 2003, Swiss-Prot Project Members, 1989.10.1) traceable author statement (Brown, 2000)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions if allele Gene References if3 blo (Walsh and Brown, 1998) bs (Wessendorf et al., 1992, Walsh and Brown, 1998) by (Lee et al., 2003) cass (Walsh and Brown, 1998) crol (D'Avino and Thummel, 2000) e(if)1 (Bloor and Brown, 1998) EcR (D'Avino and Thummel, 2000) how (Walsh and Brown, 1998) moa (Walsh and Brown, 1998) mys (Wilcox et al., 1989, Brabant and Brower, 1993) puri (Walsh and Brown, 1998) px (Wessendorf et al., 1992) RpL19 (Hart et al., 1993) sli (Wessendorf et al., 1992) ifB4 mew (Roote and Zusman, 1995, Martin-Bermudo et al., 1997, Prokop et al., 1998, Martin-Bermudo et al., 1999) ifC.Scer\UAS mew (Roote and Zusman, 1996, Martin-Bermudo et al., 1997, Li et al., 1998) ifGOF.m8.Scer\UAS mys (Baker et al., 2002) ifk27e mew (Roote and Zusman, 1995, Li et al., 1998) sli (Stevens and Jacobs, 2002) ifLOF.m8.Scer\UAS mys (Baker et al., 2002) ifm8.Scer\UAS csw (Baker et al., 2002) mew (Roote and Zusman, 1996, Martin-Bermudo et al., 1997, Li et al., 1998) msk (Baker et al., 2002) phl (Baker et al., 2002) ifm8.αTub84B csw (Baker et al., 2002) msk (Baker et al., 2002) ifScer\UAS.cMBa mew (Martin-Bermudo et al., 1997) ifunspecified mys (Jannuzi et al., 2002) ifΔ.C.Scer\UAS mew (Li et al., 1998) ifΔ.m8.Scer\UAS mew (Li et al., 1998) unspecified fad (Whalen and Simon, 2001) H (Mueller et al., 2005) mew (Levi et al., 2006) mys (Bloor and Brown, 1998, Jannuzi et al., 2004) rhea (Brown et al., 2002) rho (Sturtevant and Bier, 1995) Zasp52 (Jani and Schock, 2007)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58994 DroID - A comprehensive database of gene and protein interactions. • FBgn0001250 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32661
Orthologs
Genome-wide drosophilid orthologs	Dana\GF22287 Dere\GG18226 Dgri\GH12801 Dmoj\GI15956 Dper\GL26767 Dpse\GA21920 Dsec\GM13368 Dsim\GD15725 Dvir\GJ18848 Dwil\GK18412 Dyak\GE15645
Curated drosophilid orthologs	Dmir\CG9623 (Thornton, 2005.12.20) Dpse\GA21920   Dsim\if (Swanson et al., 2001)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL013600-PA Aedes aegypti (mosquito) AGAP000032-PA Anopheles gambiae (mosquito) XP_001120437.1 Apis mellifera (honey bee) XP_001945967.1 Acyrthosiphon pisum (pea aphid) 91205 Branchiostoma floridae (lancelet) XP_001891942.1 Brugia malayi (roundworm nematode) BGIBMGA006655-PA Bombyx mori (silk worm) ENSBTAP00000018261 Bos taurus (bovine) CBP34898 Caenorhabditis briggsae (nematode) CE00194 Caenorhabditis elegans (worm) ENSCAFP00000006951 Canis familiaris (dog) ENSCINP00000001591 Ciona intestinalis (sea squirt) JA12454 Caenorhabditis japonica (nematode) CPIJ017320 Culex pipens (mosquito) ENSCPOP00000008755 Cavia porcellus (guinea pig) RP44877 Caenorhabditis remanei (nematode) ENSCSAVP00000019709 Ciona savignyi (sedentary tunicate) 224596 Capitella spl (polychaete worm) 304328 Daphnia pulex (daphnia) ENSDARP00000094052 Danio rerio (zebra fish) ENSECAP00000011756 Equus caballus (horse) ENSGACP00000014528 Gymnopilus aculeatus (mushroom) ENSGALP00000004173 Gallus gallus (chicken) ENSP00000367316 Homo sapiens (human) 239025 Lottia gigantea (owl limpet) ENSMODP00000012596 Monodelphis domestica (gray opossum) ENSMMUP00000015308 Macaca mulatta (rhesus monkey) ENSMUSP00000028106 Mus musculus (house mouse) 196726 Nematostella vectensis (starlet anemone) XP_001601409.1 Nasonia vitripennis (wasp) ENSOANP00000007021 Ornithorynchus anatinus (platypus) ENSORLP00000014997 Oryzias latipes (japanese killifish) PHUM002805-PA Pediculus humanus (human body louse) PP22111 Pristionchus pacificus (nematode) ENSPPYP00000002453 Pongo pygmaeus (orangutan) ENSPTRP00000003927 Pan troglodytes (chimpanzee) ENSRNOP00000052152 Rattus norvegicus (norway rat) Smp_126140 Schistosoma mansoni (trematode parasite) NP_999642.1 Strongylocentrotus purpuratus (purple sea urchin) 54908 Trichoplax adhaerens (metazoa) XP_969505.2 Tribolium castaneum (red flour beetle) ENSTNIP00000015499 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000033135 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000043772 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV15746 LH16573 ISCW022321 ISCW003187 FBgn0233215 FBgn0220410 FBgn0205994 FBgn0187386 FBgn0168299 JGI_V11_304328 FBgn0081905 FBgn0164348 FBgn0138705 FBgn0120280 FBgn0110442 FBgn0099285 CPIJ017320 BGIBMGA006655 ACYPI009808 GB13598 AGAP000032 AAEL013600 PB20828 PHUM467160 GLEAN_01667
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	3960 if3 29896 w1118 Mi{ET1}ifMB10541 2176 g2 ifB2 f36a/FM7c 27544 y1 v1; P{TRiP.JF02695}attP2 2177 g2 ifk27e f36a/FM7c
Kyoto	107534 if3 106685 g2 ifB2 f36a/FM7c 106686 g2 ifk27e f36a/FM7c
VDRC	v100770 P{KK108544}VIE-260B v5600 w1118 P{GD1175}v5600 v44885 w1118; P{GD1175}v44885
Genomic Clones ( 2 )
	BACR18G21 BACR33D04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 48 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM12416 IP16423
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT02663
Other clones	632 16740 28483 29155 29425 33653 46884 48512 56692 70235 72069 78402 145598 145664 214317.2 CK01.11B.F6 CK01.24C.D7 CK01.141D.C12 CK02516 EC051283 EC051778 EC051786 EC055462 EC055912 EC056118 EK022016 EK098609 EK121424 EK128057 EK137353 EK137949 EK144457 EK165758 EK169019 EK172858 EK197916 EK200634 EK207629 EK212301 EK248554 EP11043 EP12451 IP16523 IP16623 IP16723
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0001250 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32661
Antibody Information
	monoclonal (Gullberg et al., 1994) monoclonal, polyclonal (Bogaert et al., 1987)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	ChEST reveals this is a target of Mef2. (Junion et al., 2005) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in S2R+ cells: cells become round and detached. Kc167 cells are unaffected. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) if is required in the visceral mesoderm for normal migration of the endodermal midgut cells over the visceral mesoderm in the developing embryo. (Martin-Bermudo et al., 1999) Class I and class II alleles fully complement class IV alleles. Class II alleles fully complement class III alleles. if13ts class I allele fully complements class II alleles, but the transheterozygotes between other class I alleles and class III allele generally die, although a few adult escapers are observed. (Bloor and Brown, 1998) Mutational analysis reveals if is required for the development of the adult halteres and legs, as well as the wing. if is required for the formation of the somatic muscle sarcomeric structure, rather than for its maintenance. The function of if in the morphogenesis of the midgut and nerve cord is distinct from its function in muscle attachment and sarcomeric structure. (Bloor and Brown, 1998) The functional significance of the cytoplasmic domains of the if, mew and mys subunits of the Position Specific (PS) integrin family are studied by analysing the relationship between the cytoplasmic domain structure and function in the context of a developing organism. The cytoplasmic tail of if is essential for both embryonic and postembryonic processes. (Li et al., 1998) Modulation of integrin function through the cytoplasmic domain of if is essential for embryonic morphogenesis. (Martin-Bermudo et al., 1998) if is essential for the adhesion of muscle and epidermal hemiadherens junctions to extracellular matrix at muscle attachment sites in the developing embryo. (Prokop et al., 1998) The ability of two different integrin α subunits (encoded by mew and if) to substitute for each other during embryonic development has been studied. The two α subunits encoded by mew and if are not equivalent and have distinct functions which reside in the extracellular domains. (Martin-Bermudo et al., 1997) Clonal analysis demonstrates that the different integrins, mew and if, are required on opposite wing epithelia. An early integrin-dependent process, not obviously required for prepupal adhesion, is essential to permit subsequent wing morphogenesis. (Brabant et al., 1996) if and mys can be localised by an intracellular mechanism within the muscles. Direct localisation of the transmembrane protein to sites of integrin function occurs in cells that lack endogenous mys and if or cells that lack extracellular signals from the tendon cells. (Martin-Bermudo and Brown, 1996) Either splice form of if is sufficient for viability, but they do have distinct requirements during development. if function can replace mew function in the retina. (Roote and Zusman, 1996) Phenotypic analysis of mew, if and mys embryos suggests multiple roles for PS integrins in the adhesion of cells and in the formation, organization and migration of embryonic tissues. Although the proteins are often expressed in adjacent embryonic tissues, this distribution does not necessarily reflect equivalent requirements. The complete loss of both α subunits, encoded by mew and if, does not produce all the phenotypes observed in embryos lacking the mys encoded β subunit. (Roote and Zusman, 1995) Molecular and genetic analysis prove that the αPS2 integrin subunit is encoded by the if locus. Comparison of the null phenotypes of mys (encoding the ΒPS integrin subunit) and if rules out a model where PS integrin function occurs solely by the direct interaction of the two PS integrins, αPS1ΒPS and αPS2ΒPS. (Brown, 1994) if has been expressed on the surface of Drosophila tissue culture cells. if gene product promotes cell spreading on two different extra cellular matrix (ECM) molecules, laminin and tiggin. (Gotwals et al., 1994) Muscle phenotype of mutants studied using polarised light microscopy and antibody staining to detect Mhc-lacZ reporter gene expression in muscles. (Drysdale et al., 1993) The distribution of mew, if and scb proteins in cultured cell lines has been investigated. (Peel and Milner, 1992) Scaffold attachment regions in the region surrounding if have been mapped. (Surdej et al., 1990) if gene product is the PS2α integrin subunit. if is required to ensure the correct apposition and patterning of the wing epithelia. (Wilcox et al., 1989) Structural gene for the α-subunit of position specific integrin 2 (PS2), a large transmembrane protein (Bogaert, Brown and Wilcox, 1987). The β-subunit can associate with either of the two α-subunits, PS1 or PS2 (Brower et al., 1984; Wilcox et al., 1984). Both α and β integrin are expressed in embryonic and larval tissues. In early development, PS2 is found in the mesoderm, localized to muscle attachments (Bogaert, Brown and Wilcox, 1987). Later, PS1 is expressed in the presumptive dorsal epithelium of the third instar imaginal wing discs; also, PS2 is found in the ventral epithelium, both integrins being important for the joining of the dorsal and ventral surfaces of the wing blade (Brower and Jaffe, 1989). Null mutations cause embryonic lethality (Wilcox, DiAntonio and Leptin, 1989). In the mutant if1, the adult wing is inflated with lymph and smaller than normal; venation is defective. Wings later become dry and blistered.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078654 NM_167544 NM_001169306 NM_001169307 RefSeq (Proteins) • NP_523378 NP_728021 NP_001162777 NP_001162778 DDBJ / EMBL / GenBank • AA803975 AAC12788 AAF48661 AAM50700 AAN09423 ACZ95312 ACZ95313 AY118840 M19059 Entrez Gene - A searchable database of RefSeq genes. • 32661 UniProtKB/Swiss-Prot • P12080 UniProtKB/TrEMBL • E1JJN2 Q8IR07 Q8MSG3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Integrin alpha chain, C-terminal cytoplasmic region, conserved site (IPR018184) Integrin alpha chain (IPR000413) Integrin alpha beta-propellor (IPR013519) Integrin alpha-2 (IPR013649) FG-GAP (IPR013517)
Linkouts
	BioGRID - A database of protein and genetic interactions • 58994 DroID - A comprehensive database of gene and protein interactions. • FBgn0001250 DRSC - Results from RNAi screens. • FBgn0001250 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001250 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9623-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0001250 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32661 InParanoid A subset of ortholog calls from InParanoid. • AAEL013600-PA Aedes aegypti (mosquito) AGAP000032-PA Anopheles gambiae (mosquito) XP_001120437.1 Apis mellifera (honey bee) XP_001945967.1 Acyrthosiphon pisum (pea aphid) 91205 Branchiostoma floridae (lancelet) XP_001891942.1 Brugia malayi (roundworm nematode) BGIBMGA006655-PA Bombyx mori (silk worm) ENSBTAP00000018261 Bos taurus (bovine) CBP34898 Caenorhabditis briggsae (nematode) CE00194 Caenorhabditis elegans (worm) ENSCAFP00000006951 Canis familiaris (dog) ENSCINP00000001591 Ciona intestinalis (sea squirt) JA12454 Caenorhabditis japonica (nematode) CPIJ017320 Culex pipens (mosquito) ENSCPOP00000008755 Cavia porcellus (guinea pig) RP44877 Caenorhabditis remanei (nematode) ENSCSAVP00000019709 Ciona savignyi (sedentary tunicate) 224596 Capitella spl (polychaete worm) 304328 Daphnia pulex (daphnia) ENSDARP00000094052 Danio rerio (zebra fish) ENSECAP00000011756 Equus caballus (horse) ENSGACP00000014528 Gymnopilus aculeatus (mushroom) ENSGALP00000004173 Gallus gallus (chicken) ENSP00000367316 Homo sapiens (human) 239025 Lottia gigantea (owl limpet) ENSMODP00000012596 Monodelphis domestica (gray opossum) ENSMMUP00000015308 Macaca mulatta (rhesus monkey) ENSMUSP00000028106 Mus musculus (house mouse) 196726 Nematostella vectensis (starlet anemone) XP_001601409.1 Nasonia vitripennis (wasp) ENSOANP00000007021 Ornithorynchus anatinus (platypus) ENSORLP00000014997 Oryzias latipes (japanese killifish) PHUM002805-PA Pediculus humanus (human body louse) PP22111 Pristionchus pacificus (nematode) ENSPPYP00000002453 Pongo pygmaeus (orangutan) ENSPTRP00000003927 Pan troglodytes (chimpanzee) ENSRNOP00000052152 Rattus norvegicus (norway rat) Smp_126140 Schistosoma mansoni (trematode parasite) NP_999642.1 Strongylocentrotus purpuratus (purple sea urchin) 54908 Trichoplax adhaerens (metazoa) XP_969505.2 Tribolium castaneum (red flour beetle) ENSTNIP00000015499 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000033135 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000043772 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32661 modMine - Data generated by the modENCODE project. • FBgn0001250 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV15746 LH16573 ISCW022321 ISCW003187 FBgn0233215 FBgn0220410 FBgn0205994 FBgn0187386 FBgn0168299 JGI_V11_304328 FBgn0081905 FBgn0164348 FBgn0138705 FBgn0120280 FBgn0110442 FBgn0099285 CPIJ017320 BGIBMGA006655 ACYPI009808 GB13598 AGAP000032 AAEL013600 PB20828 PHUM467160 GLEAN_01667 REDfly - A database of transcriptional regulatory elements. • FBgn0001250
Synonyms & Secondary IDs ( 27 )
Reported As
Symbol Synonym	alphaPS2 (Bouge et al., 2005) aPS2 (Prokop et al., 1997, Hoang and Chiba, 1998) CG9623 (Klebes et al., 2005, Gonzalez-Aguero et al., 2005, Keleman et al., 2009.8.5, Perkins et al., 2009, Macdonald and Long, 2006, Cammarato et al., 2011) CT27194 (Hynes and Zhao, 2000) if (Chanana et al., 2007, Devenport et al., 2007, Dietzl et al., 2007, Tsai et al., 2008, Christensen et al., 2008.9.3, Christensen et al., 2008.9.3, Christensen et al., 2008.9.3, Ritzenthaler and Chiba, 2003, Huang et al., 2007, Christensen et al., 2008.12.28, O'Reilly et al., 2008, Estrada et al., 2007, Inoue and Hayashi, 2007, Christensen et al., 2009.2.28, Liu et al., 2009, Junion et al., 2007, Dinkins et al., 2008, Jattani et al., 2009, Gilsohn and Volk, 2010, Popodi et al., 2010-, Fraichard et al., 2010, Zhang et al., 2010, Tikhmyanova et al., 2010, Beltran et al., 2007, Zhang et al., 2008, Zervas et al., 2011, Perkins et al., 2010, Negreiros et al., 2010) If (Tikhmyanova et al., 2010) in (Bryant, 1997) inf (McKim et al., 1996) integrin (Rui et al., 2010) PS2 (Solnica-Krezel and Eaton, 2003, Bloor and Kiehart, 2000, Roch and Akam, 2000, Hobert and Westphal, 2000, Bogaert, 1998.4.7, Micchelli and Blair, 1999, Martin-Bermudo and Brown, 1999, Brabant et al., 1996, Fernandes et al., 1996, Woods and Bryant, 1993, Bate, 1993, Peel and Milner, 1992, Subramanian et al., 2007, Kiger et al., 2007) PS 2 (Surdej et al., 1990, Brun et al., 1990) PS2α (Sanchez et al., 1997, Wessendorf et al., 1992, Bunch and Brower, 1992, Leptin, 1991, Hirano et al., 1991, Polito et al., 1990) PSα2 (Jenkins et al., 2001, Delanoue et al., 2002) α2Int (Huang et al., 2007) αPS2(ms8) (Bunch et al., 1992) αPS2 (Bradley et al., 2003, Martin-Bermudo et al., 1999, Fujimoto et al., 1999, Graner et al., 1998, Bunch et al., 1998, Prokop et al., 1998, Li et al., 1998, Bloor and Brown, 1998, Martin-Bermudo et al., 1997, Lin et al., 1997, Martin-Bermudo and Brown, 1996, Ashkenas et al., 1996, Martin-Bermudo and Brown, 1996, Fessler et al., 1994, Abmayr et al., 1995, Fogerty et al., 1994, Blair et al., 1994, Wehrli et al., 1993, Brown, 1993, Gullberg et al., 1994, Chanana et al., 2007) αPS2 (Grabbe et al., 2004, Devenport and Brown, 2004, Stevens and Jacobs, 2002, Brower, 2003, Abrams et al., 2003, Schock and Perrimon, 2003, Bokel and Brown, 2002, Baker et al., 2002, Jannuzi et al., 2002, Bloor and Kiehart, 2001, Zervas et al., 2001, Martin-Bermudo and Brown, 2000, Hynes and Zhao, 2000, Brown, 2000, Martin-Bermudo, 2000, Brown et al., 2000, D'Avino and Thummel, 2000, Kim and Chiba, 2000, Beumer et al., 1999, de Melker and Sonnenberg, 1999, Hoang and Chiba, 1998, Martin-Bermudo et al., 1998, Martin-Bermudo et al., 1997, Fleming et al., 1997, Prokop et al., 1996, Olson et al., 1995, Yarnitzky and Volk, 1995, Gotwals et al., 1994, Gotwals et al., 1994, Brown et al., 1993, Lo, 2006, Hughes, 2001, Loer et al., 2008, Jani and Schock, 2007, Schotman et al., 2008, Nguyen et al., 2007, O'Reilly et al., 2008, Inoue and Hayashi, 2007, Devenport et al., 2007, Fernandez-Minan et al., 2007, James et al., 2007, Tanentzapf and Brown, 2006, Tanentzapf et al., 2007, Tanentzapf et al., 2006, Dinkins et al., 2008, Jattani et al., 2009, Fraichard et al., 2010, Egoz-Matia et al., 2011, Zervas et al., 2011, Pines et al., 2011, Bunch et al., 2004) αPS2C (Bunch et al., 2006)
Name Synonym	inflated (Levi et al., 2006, Sandmann et al., 2007, Ayyub and Paranjape, 2002, Chanana et al., 2007, Ritzenthaler and Chiba, 2003, Sandmann et al., 2006, O'Reilly et al., 2008, Devenport et al., 2007, Dinkins et al., 2008, Jattani et al., 2009, Gilsohn and Volk, 2010, Siekhaus et al., 2010, Fraichard et al., 2010, Egoz-Matia et al., 2011, Cammarato et al., 2011) position-specific antigen 2 (Bogaert, 1998.4.7) α2 integrin (Huang et al., 2007) αPS2 integrin (Chanana et al., 2007) α integrin (Fujimoto et al., 1997) αPS2 (Negreiros et al., 2010) αPS2 integrin (Ribeiro et al., 2003, Lo, 2006, Loer et al., 2008, Ritzenthaler and Chiba, 2003, Nguyen et al., 2007, Jattani et al., 2009) α-PS2-integrin (Kohsaka et al., 2007) αPS2 Integrin (Zhang et al., 2010) αPS2-integrin (Pines et al., 2011)
Secondary FlyBase IDs
References ( 240 )
Generate a list of	All references relating to this gene ( 240 )
List References by type	Research paper  ( 149 ) Supplementary material  ( 6 ) Review  ( 31 ) Personal communication to FlyBase  ( 16 ) Abstract  ( 25 ) FlyBase analysis  ( 2 ) Conference report  ( 1 ) DNA/RNA sequence record  ( 2 ) Protein sequence record  ( 1 ) Book  ( 2 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 13 )
	Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Egoz-Matia et al., 2011, Dev. Biol. 351(1): 99--109 Spatial regulation of cell adhesion in the Drosophila wing is mediated by Delilah, a potent activator of βPS integrin expression. [FBrf0213026] Pines et al., 2011, Dev. Dyn. 240(1): 36--51 Distinct regulatory mechanisms control integrin adhesive processes during tissue morphogenesis. [FBrf0212613] Ribeiro et al., 2011, PLoS Genet. 7(2): e1001295 Phosphoinositide regulation of integrin trafficking required for muscle attachment and maintenance. [FBrf0213137] Zervas et al., 2011, J. Cell Sci. 124(8): 1316--1327 A central multifunctional role of integrin-linked kinase at muscle attachment sites. [FBrf0213331] Fraichard et al., 2010, Dev. Biol. 340(2): 504--517 Tenectin is a novel alphaPS2betaPS integrin ligand required for wing morphogenesis and male genital looping in Drosophila. [FBrf0210522] Gilsohn and Volk, 2010, Development 137(5): 785--794 Slowdown promotes muscle integrity by modulating integrin-mediated adhesion at the myotendinous junction. [FBrf0209925] Negreiros et al., 2010, genesis 48(1): 31--43 alphaPS1betaPS integrin receptors regulate the differential distribution of Sog fragments in polarized epithelia. [FBrf0209674] Perkins et al., 2010, Dev. Biol. 338(1): 15--27 Integrin-mediated adhesion maintains sarcomeric integrity. [FBrf0215081] Rui et al., 2010, PLoS Genet. 6(11): e1001208 Sarcomere formation occurs by the assembly of multiple latent protein complexes. [FBrf0212444] Siekhaus et al., 2010, Nat. Cell Biol. 12(6): 605--610 RhoL controls invasion and Rap1 localization during immune cell transmigration in Drosophila. [FBrf0210888] Tikhmyanova et al., 2010, PLoS ONE 5(8): e12369 Dcas supports cell polarization and cell-cell adhesion complexes in development. [FBrf0211678] Zhang et al., 2010, J. Biol. Chem. 285(25): 19491--19501 An O-Glycosyltransferase Promotes Cell Adhesion during Development by Influencing Secretion of an Extracellular Matrix Integrin Ligand. [FBrf0211018] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...