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Gene Dmel\ImpL2

General Information
Symbol	Dmel\ImpL2	Species	D. melanogaster
Name	Ecdysone-inducible gene L2	Annotation symbol	CG15009
Feature type	protein_coding_gene	FlyBase ID	FBgn0001257
Gene Model Status	Current	Stock availability	12 publicly available
Also Known As	Imp-L2, ImpL-2
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	64A10-64A10	Sequence location	3L:4,224,699..4,236,147 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ecdysone-inducible gene L2 is referred to in FlyBase by the symbol Dmel\ImpL2 (CG15009, FBgn0001257). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: negative regulation of insulin receptor signaling pathway. 27 alleles are reported. The phenotypes of these alleles are annotated with: eye; ovary. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Immunoglobulin I-set; Immunoglobulin subtype 2; Immunoglobulin-like; Immunoglobulin-like fold. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult thoracico-abdominal ganglion, larval hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, larval/adult midgut, adult hindgut, larval Malpighian tubules, larval trachea, adult female reproductive system. Comments on Affy2 ProbeSet: ProbeSet 1636202_s_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of ImpL2. Gene sequence location is 3L:4224699..4236147.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Imp-L: Imp-Late Imp-L encoding transcripts associated with membrane-bound polysomes in imaginal discs and expressed only in response to 20-hydroxyecdysone (20 HOE). Expression studied both in vitro and in vivo. Imp-L denotes three "late" genes involved in the eversion to the exterior of the elongated regions of discs by means of local changes in cell shape (Osterbur et al., 1988).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features BKN32218 BKN45830 HFA08666
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 64A10-64A10   Limits computationally determined from genome sequence between P{PZ}l(3)rG166rG166 and P{PZ}sinu06524
Experimentally Determined Cytological Location
Cytogenetic map Notes References 64B1-64B2   (determined by in situ hybridisation)   (Garbe et al., 1993) 64B-64B   (determined by in situ hybridisation)   (Natzle et al., 1986)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\ImpL2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) ImpL2-RA FBtr0073248  NM_079197   1178   266 ImpL2-RB FBtr0073249  NM_168069   1630   263 ImpL2-RC FBtr0073250  NM_168070   1000   267
Additional Transcript Data & Comments
Reported size (kB)	2.4 (northern blot) (Garbe et al., 1993)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein ImpL2-PA   FBpp0073104   29.8   266   6.24     NP_523921   AAF47866 ImpL2-PB   FBpp0073105   29.4   263   6.04     NP_728960   AAN11593 ImpL2-PC   FBpp0073106   29.9   267   6.04     NP_728961   AAN11594
Additional Polypeptide Data & Comments
Reported size (kDa)	263 (aa); 32 (kD observed); 27 (kD predicted) (Garbe et al., 1993)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Immunoglobulin subtype 2 (IPR003598) Immunoglobulin-like (IPR007110) Immunoglobulin-like fold (IPR013783) Immunoglobulin I-set (IPR013098)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA246942   AA697938   AE014296 AAF47866   AE014296 AAN11593   AE014296 AAN11594   AI257195   AI258000   AI258899   AI261136   AI517520   AI534445   AI534836   AI542087   AI543329   AI543357   AW944490   AY060476 AAL25515   BG635435   BG637173   BG639324   BG640000   BH840508   BI142111   BI212499   BI216400   BI232595   BI235334   BI237394   BI356624   BI362462   BI374194   BI374286   BI483289   BI577951   BI578496   BI632144   BI632245   BI633394   BI633521   BI633973   BI635406   BI635983   BI637610   BI638193   BI638948   BI639796   BI640368   BI640744   BI641191   BP550977   BP557911   BQ103709   BT012298   BT012299   CK659506   CK660122   CO152872   CO153007   CO153869   CO155080   CO176774   CO179473   CO187340   CO265256   CO266828   CO267006   CO267020   CO268605   CO271838   CO272062   CO272429   CO275767   CO283775   CO284599   CO286218   CO289333   CO295246   CO296764   CO304406   CO319104   CO321673   CO323083   CZ471921   CZ471922   CZ472550   CZ472883   CZ474093   CZ474477   CZ474478   CZ474585   CZ477375   CZ477853   DQ062766 AAY56639   EC061943   EC067129   EC069246   EC071795   EC073084   EC074640   EC075756   EC080395   EC080622   EC084374   EC089894   EC197463   EC207430   EC211816   EC219714   EC224671   EC232168   EC232857   EC233445   EC237235   EC240929   EC243316   EC244673   EC264711   EC267057   EC267216   EL877234   EV593960   FF579225   FF579361   FF579610   GH941867   GH953774   GH954877   GH964590   GH971897   GH974052   GH974977   GH975911   GH976653   GH984008   L23066 AAB59248   L23066 AAB59249   L23066 AAB59250   L23066 AAB59251
UniProtKB/Swiss-Prot	Q09024
UniProtKB/TrEMBL	Q24364 Q24365 Q24366 Q3YMW0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 5   organism | pair rule expression pattern   (Garbe et al., 1993) embryonic stage 8   neurogenic region   (Garbe et al., 1993) embryonic stage 9   tracheal pit   (Garbe et al., 1993) embryonic stage 15 -- 16   frontal head air sac   (Garbe et al., 1993) embryonic/larval pharynx   (Garbe et al., 1993) embryonic/larval posterior spiracle   (Garbe et al., 1993) embryonic/larval esophagus   (Garbe et al., 1993) embryonic stage 15 -- 17   bipolar dendrite neuron   (Garbe et al., 1993)
Additional Descriptive Data
	ImpL2 transcripts are not detected until 4hr of embyronic development on northern blots. By in situ hybridization, they are detected in blastoderm embryos in a pair-rule-like pattern of seven stripes. The stripes extend through the neurogenic and dorsal epidermal regions but not extend to the presumptive mesoderm or amnioserosa. At stage 8, 14 broad bands are seen in the neurogenic ectoderm. At stage 9, strong expression is seen surrounding the tracheal pits. During stages 15-16, ImpL2 transcripts are detected in the pharynx, frontal sac, the esophagus, surrounding the posterior spiracles, and the lateral bipolar dendrite neurons. By stage 17, they are limited to the lateral bipolar dendrite neurons and other structures that show accumulation of protein. (Garbe et al., 1993)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 16 -- 17   bipolar dendrite neuron   (Garbe et al., 1993) procephalic segment   (Garbe et al., 1993) embryonic optic lobe primordium   (Garbe et al., 1993) multidendritic neuron   (Garbe et al., 1993) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
	ImpL2 protein is weakly detected in embryonic extracts from 2-4hrs and a stronger signal is seen in 4-6hr and 6-8hr embryos. No localized ImpL2 protein was detected until stage 16 at which time a segmentally repeated pattern of staining in the lateral region is observed. The stained cells in the abdominal segments were identified as the lateral bipolar dendrite neurons. In the thoracic segments, similarly positioned neuronal cell bodies and their axons were stained but their identity is uncertain. They are probably multiple dendritic neurons. Staining is also observed in two neurons adjacent to the pharynx, in two cell clusters on the dorsolateral surface of the optic lobes, and in a localized area of the cephalic region. (Garbe et al., 1993)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0001257    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0001257 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0001257 expression level Developmental Stage   Expression Level embryo 00-02hr    388 embryo 02-04hr    6296 embryo 04-06hr    27198 embryo 06-08hr    18443 embryo 08-10hr    16066 embryo 10-12hr    13207 embryo 12-14hr    10865 embryo 14-16hr    7713 embryo 16-18hr    5150 embryo 18-20hr    8243 embryo 20-22hr    3408 embryo 22-24hr    4285 larva L1    3213 larva L2    2781 larva L3 12hr old    2081 larva L3 puffstage 1-2    1847 larva L3 puffstage 3-6    4147 larva L3 puffstage 7-9    5434 white prepupae new    4939 white prepupae 12hr    7575 white prepupae 24hr    5385 pupae 2d postWPP    3991 pupae 3d postWPP    2528 pupae 4d postWPP    3757 adult male 01day    2425 adult male 05day    3044 adult male 30day    3658 adult female 01day    2461 adult female 05day    2621 adult female 30day    3002 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (388) embryo 02-04hr  (6296) embryo 04-06hr  (27198) embryo 06-08hr  (18443) embryo 08-10hr  (16066) embryo 10-12hr  (13207) embryo 12-14hr  (10865) embryo 14-16hr  (7713) embryo 16-18hr  (5150) embryo 18-20hr  (8243) embryo 20-22hr  (3408) embryo 22-24hr  (4285) larva L1  (3213) larva L2  (2781) larva L3 12hr old  (2081) larva L3 puffstage 1-2  (1847) larva L3 puffstage 3-6  (4147) larva L3 puffstage 7-9  (5434) white prepupae new  (4939) white prepupae 12hr  (7575) white prepupae 24hr  (5385) pupae 2d postWPP  (3991) pupae 3d postWPP  (2528) pupae 4d postWPP  (3757) adult male 01day  (2425) adult male 05day  (3044) adult male 30day  (3658) adult female 01day  (2461) adult female 05day  (2621) adult female 30day  (3002) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    388 embryo 02-04hr  (6296) embryo 04-06hr  (27198) embryo 06-08hr  (18443) embryo 08-10hr  (16066) embryo 10-12hr  (13207) embryo 12-14hr  (10865) embryo 14-16hr  (7713) embryo 16-18hr  (5150) embryo 18-20hr  (8243) embryo 20-22hr  (3408) embryo 22-24hr  (4285) larva L1  (3213) larva L2  (2781) larva L3 12hr old  (2081) larva L3 puffstage 1-2  (1847) larva L3 puffstage 3-6  (4147) larva L3 puffstage 7-9  (5434) white prepupae new  (4939) white prepupae 12hr  (7575) white prepupae 24hr  (5385) pupae 2d postWPP  (3991) pupae 3d postWPP  (2528) pupae 4d postWPP  (3757) adult male 01day  (2425) adult male 05day  (3044) adult male 30day  (3658) adult female 01day  (2461) adult female 05day  (2621) adult female 30day  (3002) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    388 embryo 02-04hr    6296 embryo 04-06hr  (27198) embryo 06-08hr  (18443) embryo 08-10hr  (16066) embryo 10-12hr  (13207) embryo 12-14hr  (10865) embryo 14-16hr    7713 embryo 16-18hr    5150 embryo 18-20hr    8243 embryo 20-22hr    3408 embryo 22-24hr    4285 larva L1    3213 larva L2    2781 larva L3 12hr old    2081 larva L3 puffstage 1-2    1847 larva L3 puffstage 3-6    4147 larva L3 puffstage 7-9    5434 white prepupae new    4939 white prepupae 12hr    7575 white prepupae 24hr    5385 pupae 2d postWPP    3991 pupae 3d postWPP    2528 pupae 4d postWPP    3757 adult male 01day    2425 adult male 05day    3044 adult male 30day    3658 adult female 01day    2461 adult female 05day    2621 adult female 30day    3002 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    388 embryo 02-04hr    6296 embryo 04-06hr    27198 embryo 06-08hr    18443 embryo 08-10hr    16066 embryo 10-12hr    13207 embryo 12-14hr    10865 embryo 14-16hr    7713 embryo 16-18hr    5150 embryo 18-20hr    8243 embryo 20-22hr    3408 embryo 22-24hr    4285 larva L1    3213 larva L2    2781 larva L3 12hr old    2081 larva L3 puffstage 1-2    1847 larva L3 puffstage 3-6    4147 larva L3 puffstage 7-9    5434 white prepupae new    4939 white prepupae 12hr    7575 white prepupae 24hr    5385 pupae 2d postWPP    3991 pupae 3d postWPP    2528 pupae 4d postWPP    3757 adult male 01day    2425 adult male 05day    3044 adult male 30day    3658 adult female 01day    2461 adult female 05day    2621 adult female 30day    3002 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0001257 expression level Developmental Stage   Expression Level embryo 00-02hr    388 embryo 02-04hr    6296 embryo 04-06hr    27198 embryo 06-08hr    18443 embryo 08-10hr    16066 embryo 10-12hr    13207 embryo 12-14hr    10865 embryo 14-16hr    7713 embryo 16-18hr    5150 embryo 18-20hr    8243 embryo 20-22hr    3408 embryo 22-24hr    4285 larva L1    3213 larva L2    2781 larva L3 12hr old    2081 larva L3 puffstage 1-2    1847 larva L3 puffstage 3-6    4147 larva L3 puffstage 7-9    5434 white prepupae new    4939 white prepupae 12hr    7575 white prepupae 24hr    5385 pupae 2d postWPP    3991 pupae 3d postWPP    2528 pupae 4d postWPP    3757 adult male 01day    2425 adult male 05day    3044 adult male 30day    3658 adult female 01day    2461 adult female 05day    2621 adult female 30day    3002 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (388) embryo 02-04hr  (6296) embryo 04-06hr  (27198) embryo 06-08hr  (18443) embryo 08-10hr  (16066) embryo 10-12hr  (13207) embryo 12-14hr  (10865) embryo 14-16hr  (7713) embryo 16-18hr  (5150) embryo 18-20hr  (8243) embryo 20-22hr  (3408) embryo 22-24hr  (4285) larva L1  (3213) larva L2  (2781) larva L3 12hr old  (2081) larva L3 puffstage 1-2  (1847) larva L3 puffstage 3-6  (4147) larva L3 puffstage 7-9  (5434) white prepupae new  (4939) white prepupae 12hr  (7575) white prepupae 24hr  (5385) pupae 2d postWPP  (3991) pupae 3d postWPP  (2528) pupae 4d postWPP  (3757) adult male 01day  (2425) adult male 05day  (3044) adult male 30day  (3658) adult female 01day  (2461) adult female 05day  (2621) adult female 30day  (3002) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    388 embryo 02-04hr  (6296) embryo 04-06hr  (27198) embryo 06-08hr  (18443) embryo 08-10hr  (16066) embryo 10-12hr  (13207) embryo 12-14hr  (10865) embryo 14-16hr  (7713) embryo 16-18hr  (5150) embryo 18-20hr  (8243) embryo 20-22hr  (3408) embryo 22-24hr  (4285) larva L1  (3213) larva L2  (2781) larva L3 12hr old  2081 larva L3 puffstage 1-2  1847 larva L3 puffstage 3-6  (4147) larva L3 puffstage 7-9  (5434) white prepupae new  (4939) white prepupae 12hr  (7575) white prepupae 24hr  (5385) pupae 2d postWPP  (3991) pupae 3d postWPP  (2528) pupae 4d postWPP  (3757) adult male 01day  2425 adult male 05day  (3044) adult male 30day  (3658) adult female 01day  2461 adult female 05day  (2621) adult female 30day  (3002) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    388 embryo 02-04hr    6296 embryo 04-06hr  (27198) embryo 06-08hr  18443 embryo 08-10hr  16066 embryo 10-12hr  13207 embryo 12-14hr  10865 embryo 14-16hr    7713 embryo 16-18hr    5150 embryo 18-20hr    8243 embryo 20-22hr    3408 embryo 22-24hr    4285 larva L1    3213 larva L2    2781 larva L3 12hr old    2081 larva L3 puffstage 1-2    1847 larva L3 puffstage 3-6    4147 larva L3 puffstage 7-9    5434 white prepupae new    4939 white prepupae 12hr    7575 white prepupae 24hr    5385 pupae 2d postWPP    3991 pupae 3d postWPP    2528 pupae 4d postWPP    3757 adult male 01day    2425 adult male 05day    3044 adult male 30day    3658 adult female 01day    2461 adult female 05day    2621 adult female 30day    3002 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    388 embryo 02-04hr    6296 embryo 04-06hr    27198 embryo 06-08hr    18443 embryo 08-10hr    16066 embryo 10-12hr    13207 embryo 12-14hr    10865 embryo 14-16hr    7713 embryo 16-18hr    5150 embryo 18-20hr    8243 embryo 20-22hr    3408 embryo 22-24hr    4285 larva L1    3213 larva L2    2781 larva L3 12hr old    2081 larva L3 puffstage 1-2    1847 larva L3 puffstage 3-6    4147 larva L3 puffstage 7-9    5434 white prepupae new    4939 white prepupae 12hr    7575 white prepupae 24hr    5385 pupae 2d postWPP    3991 pupae 3d postWPP    2528 pupae 4d postWPP    3757 adult male 01day    2425 adult male 05day    3044 adult male 30day    3658 adult female 01day    2461 adult female 05day    2621 adult female 30day    3002 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0001257    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0001257 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult thoracico-abdominal ganglion, larval hindgut, adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, larval/adult central nervous system, larval/adult midgut, adult hindgut, larval Malpighian tubules, larval trachea, adult female reproductive system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0001257 expression level Tissue   Expression Level Larval Central Nervous System    414.725 Larval Midgut    499.8 Larval Hindgut    683.7 Larval Malpighian Tubules    249.2 Larval Fat Body    951.1 Larval Salivary Gland no informative data Larval Trachea    268.225 Larval Carcass    1868.325 Adult Head    512.2 Adult Eye    265.45 Adult Brain    421.7 Adult Thoracic-Abdominal Ganglion    963.3 Adult Crop    60.6 Adult Midgut    249.3 Adult Hindgut    381.5 Adult Malpighian Tubules    606.4 Adult Fat Body    1106.3 Adult Salivary Gland no informative data Adult Heart    2027.95 Adult VirginFemale Spermatheca    113.8 Adult InseminatedFemale Spermatheca    144.5 Adult Ovary    190.9 Adult Testis    49.2 Adult Male Accessory Gland no informative data Adult Carcass    1099.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    414.725 Larval Midgut    499.8 Larval Hindgut  (683.7) Larval Malpighian Tubules    249.2 Larval Fat Body  (951.1) Larval Salivary Gland no informative data Larval Trachea    268.225 Larval Carcass  (1868.325) Adult Head  512.2 Adult Eye    265.45 Adult Brain    421.7 Adult Thoracic-Abdominal Ganglion  (963.3) Adult Crop    60.6 Adult Midgut    249.3 Adult Hindgut    381.5 Adult Malpighian Tubules  (606.4) Adult Fat Body  (1106.3) Adult Salivary Gland no informative data Adult Heart  (2027.95) Adult VirginFemale Spermatheca    113.8 Adult InseminatedFemale Spermatheca    144.5 Adult Ovary    190.9 Adult Testis    49.2 Adult Male Accessory Gland no informative data Adult Carcass  (1099.7) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    414.725 Larval Midgut    499.8 Larval Hindgut    683.7 Larval Malpighian Tubules    249.2 Larval Fat Body    951.1 Larval Salivary Gland no informative data Larval Trachea    268.225 Larval Carcass  (1868.325) Adult Head    512.2 Adult Eye    265.45 Adult Brain    421.7 Adult Thoracic-Abdominal Ganglion    963.3 Adult Crop    60.6 Adult Midgut    249.3 Adult Hindgut    381.5 Adult Malpighian Tubules    606.4 Adult Fat Body  (1106.3) Adult Salivary Gland no informative data Adult Heart  (2027.95) Adult VirginFemale Spermatheca    113.8 Adult InseminatedFemale Spermatheca    144.5 Adult Ovary    190.9 Adult Testis    49.2 Adult Male Accessory Gland no informative data Adult Carcass  (1099.7) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    414.725 Larval Midgut    499.8 Larval Hindgut    683.7 Larval Malpighian Tubules    249.2 Larval Fat Body    951.1 Larval Salivary Gland no informative data Larval Trachea    268.225 Larval Carcass    1868.325 Adult Head    512.2 Adult Eye    265.45 Adult Brain    421.7 Adult Thoracic-Abdominal Ganglion    963.3 Adult Crop    60.6 Adult Midgut    249.3 Adult Hindgut    381.5 Adult Malpighian Tubules    606.4 Adult Fat Body    1106.3 Adult Salivary Gland no informative data Adult Heart    2027.95 Adult VirginFemale Spermatheca    113.8 Adult InseminatedFemale Spermatheca    144.5 Adult Ovary    190.9 Adult Testis    49.2 Adult Male Accessory Gland no informative data Adult Carcass    1099.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0001257 expression level Tissue   Expression Level Larval Central Nervous System    414.725 Larval Midgut    499.8 Larval Hindgut    683.7 Larval Malpighian Tubules    249.2 Larval Fat Body    951.1 Larval Salivary Gland no informative data Larval Trachea    268.225 Larval Carcass    1868.325 Adult Head    512.2 Adult Eye    265.45 Adult Brain    421.7 Adult Thoracic-Abdominal Ganglion    963.3 Adult Crop    60.6 Adult Midgut    249.3 Adult Hindgut    381.5 Adult Malpighian Tubules    606.4 Adult Fat Body    1106.3 Adult Salivary Gland no informative data Adult Heart    2027.95 Adult VirginFemale Spermatheca    113.8 Adult InseminatedFemale Spermatheca    144.5 Adult Ovary    190.9 Adult Testis    49.2 Adult Male Accessory Gland no informative data Adult Carcass    1099.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    414.725 Larval Midgut    499.8 Larval Hindgut  683.7 Larval Malpighian Tubules    249.2 Larval Fat Body  (951.1) Larval Salivary Gland no informative data Larval Trachea    268.225 Larval Carcass  (1868.325) Adult Head  512.2 Adult Eye    265.45 Adult Brain    421.7 Adult Thoracic-Abdominal Ganglion  (963.3) Adult Crop    60.6 Adult Midgut    249.3 Adult Hindgut    381.5 Adult Malpighian Tubules  606.4 Adult Fat Body  (1106.3) Adult Salivary Gland no informative data Adult Heart  (2027.95) Adult VirginFemale Spermatheca    113.8 Adult InseminatedFemale Spermatheca    144.5 Adult Ovary    190.9 Adult Testis    49.2 Adult Male Accessory Gland no informative data Adult Carcass  (1099.7) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    414.725 Larval Midgut    499.8 Larval Hindgut    683.7 Larval Malpighian Tubules    249.2 Larval Fat Body    951.1 Larval Salivary Gland no informative data Larval Trachea    268.225 Larval Carcass  (1868.325) Adult Head    512.2 Adult Eye    265.45 Adult Brain    421.7 Adult Thoracic-Abdominal Ganglion    963.3 Adult Crop    60.6 Adult Midgut    249.3 Adult Hindgut    381.5 Adult Malpighian Tubules    606.4 Adult Fat Body  1106.3 Adult Salivary Gland no informative data Adult Heart  (2027.95) Adult VirginFemale Spermatheca    113.8 Adult InseminatedFemale Spermatheca    144.5 Adult Ovary    190.9 Adult Testis    49.2 Adult Male Accessory Gland no informative data Adult Carcass  1099.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    414.725 Larval Midgut    499.8 Larval Hindgut    683.7 Larval Malpighian Tubules    249.2 Larval Fat Body    951.1 Larval Salivary Gland no informative data Larval Trachea    268.225 Larval Carcass    1868.325 Adult Head    512.2 Adult Eye    265.45 Adult Brain    421.7 Adult Thoracic-Abdominal Ganglion    963.3 Adult Crop    60.6 Adult Midgut    249.3 Adult Hindgut    381.5 Adult Malpighian Tubules    606.4 Adult Fat Body    1106.3 Adult Salivary Gland no informative data Adult Heart    2027.95 Adult VirginFemale Spermatheca    113.8 Adult InseminatedFemale Spermatheca    144.5 Adult Ovary    190.9 Adult Testis    49.2 Adult Male Accessory Gland no informative data Adult Carcass    1099.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland no informative data Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    512.2   NA  Eye    265.45   NA  Brain    421.7   414.725  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    963.3   NA  Crop    60.6   499.8  Midgut    249.3   683.7  Hindgut    381.5   249.2  Malpighian Tubules    606.4   951.1  Fat Body    1106.3   no informative data  Salivary Gland    no informative data   NA  Heart    2027.95   268.225  Trachea    NA   NA  VirginFemale Spermatheca    113.8   NA  InseminatedFemale Spermatheca    144.5   NA  Ovary    190.9   NA  Testis    49.2   NA  Male Accessory Gland    no informative data   1868.325  Carcass    1099.7 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001257 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15009-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for ImpL2 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4Act5C.PI ImpL2s.Scer\UAS ImpL2Scer\UAS.cHa lethal, with Scer\GAL4arm.PS ImpL2s.Scer\UAS lethal, with Scer\GAL4ppl.PP ImpL2s.Scer\UAS viable ImpL2EY16442 viable, with Scer\GAL4hs.PB ImpL2Scer\UAS.cHa viable, with Scer\GAL4pnr-MD237 ImpL2GD6004 viable (with ImpL2Def20) ImpL2Def42 viable (with ImpL2Def42) ImpL2Def20 Sterility Allele fertile ImpL2EY16442 Other Phenotypes Allele decreased cell size | somatic clone, with Scer\GAL4GMR.PB ImpL2Scer\UAS.cHa developmental rate defective, with Scer\GAL4GMR.PF ImpL2s.Scer\UAS developmental rate defective, with Scer\GAL4ppl.PP ImpL2Scer\UAS.cHa hyperplasia (with ImpL2Def20) ImpL2Def42 hyperplasia (with ImpL2Def42) ImpL2Def20 large body (with ImpL2Def20) ImpL2Def42 large body (with ImpL2Def42) ImpL2Def20 long lived | female limited, with Scer\GAL4hs.PB ImpL2Scer\UAS.cHa long lived | female limited, with Scer\GAL4Ilp2.215-3 ImpL2Scer\UAS.cHa long lived | female limited | RU486 conditional, with Scer\GAL4Act5C.Switch.PR ImpL2Scer\UAS.cHa long lived | female limited | RU486 conditional, with Scer\GAL4Switch1.106 ImpL2Scer\UAS.cHa small body, with Scer\GAL4arm.PS ImpL2Scer\UAS.cHa small body, with Scer\GAL4ppl.PP ImpL2Scer\UAS.cHa stress response defective | female limited, with Scer\GAL4hs.PB ImpL2Scer\UAS.cHa stress response defective | female limited | RU486 conditional, with Scer\GAL4Act5C.Switch.PR ImpL2Scer\UAS.cHa stress response defective | third instar larval stage (with ImpL2Def20) ImpL2Def42 stress response defective | third instar larval stage (with ImpL2Def42) ImpL2Def20 wild-type ImpL2+t5.2 Phenotype manifest in Allele eye, with Scer\GAL4GMR.PF ImpL2Scer\UAS.cHa ImpL2s.Scer\UAS ovary (with ImpL2Def20) ImpL2Def42 ovary (with ImpL2Def42) ImpL2Def20
Classical Alleles ( 21 )
For All Classical Alleles Show
Allele of ImpL2 Class Mutagen Stocks Known lesion ImpL2d00958 P-element activity 1 -- ImpL2d01988 P-element activity 1 -- ImpL2d02555 P-element activity 1 -- ImpL2d04726 P-element activity 1 -- ImpL2EY00981 P-element activity 1 -- ImpL2EY16442 P-element activity 1 -- ImpL2KG02223 P-element activity 1 -- ImpL2MB04721 1 -- ImpL2MI01638 1 -- ImpL2d05349 P-element activity 0 -- ImpL2d05524 P-element activity 0 -- ImpL2d10664 P-element activity 0 -- ImpL2d11668 P-element activity 0 -- ImpL2Def20 Delta2-3 0 Yes ImpL2Def223 Delta2-3 0 Yes ImpL2Def29 Delta2-3 0 Yes ImpL2Def35 Delta2-3 0 Yes ImpL2Def42 Delta2-3 0 Yes ImpL2EP5.66 P-element activity 0 Yes ImpL2GE24013 P-element activity 0 Yes ImpL2MG2 loss of function allele ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of ImpL2 Class Mutagen Stocks Known lesion ImpL2GD6004 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes ImpL2KK112218 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ImpL2+t5.2 in vitro construct - genomic fragment 0 Yes ImpL2+t9 in vitro construct - genomic fragment 0 Yes ImpL2s.Scer\UAS in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes ImpL2Scer\UAS.cHa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)ems13 (Garbe et al., 1993) Df(3L)GN19 (Garbe et al., 1993)
Not disrupted in	Df(3L)A466 (Garbe et al., 1993)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6004} NA P{KK112218} NA P{UAS-ImpL2.H} NA P{UAS-ImpL2.strong} NA characterization construct P{ImpL29} NA P{ImpL2+} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions Mi{MIC}ImpL2MI01638 NA P{}ImpL2GE24013 NA P{SUPor-P}ImpL2KG02223 NA insertion of mobile activating element P{EP}ImpL2EP5.66 NA P{EPgy2}ImpL2EY00981 NA P{EPgy2}ImpL2EY16442 NA P{XP}ImpL2d00958 NA P{XP}ImpL2d01988 NA P{XP}ImpL2d02555 NA P{XP}ImpL2d04726 NA P{XP}ImpL2d05349 NA P{XP}ImpL2d05524 NA P{XP}ImpL2d10664 NA P{XP}ImpL2d11668 NA insertion of enhancer trap binary system Mi{ET1}ImpL2MB04721 No
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
negative regulation of insulin receptor signaling pathway inferred from genetic interaction with Ilp2 (Honegger et al., 2008) inferred from genetic interaction with InR (Honegger et al., 2008)
Cellular Component
CV term Evidence References
extracellular space inferred from direct assay (Alic et al., 2011)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cell adhesion traceable author statement (Gibson and Schubiger, 2001)
Cellular Component
CV term Evidence References
extracellular region non-traceable author statement (Swiss-Prot Project Members, 1999.7.15)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions ImpL2 allele Gene References ImpL2KG02223 h (Bianchi-Frias et al., 2004)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63991 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0001257 DroID - A comprehensive database of gene and protein interactions. • FBgn0001257 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38513
Orthologs
Genome-wide drosophilid orthologs	Dana\GF23872 Dere\GG14204 Dgri\GH15542 Dmoj\GI16817 Dper\GL12728 Dpse\GA16789 Dsec\GM13995 Dsim\ImpL2 Dvir\GJ12564 Dwil\GK10204 Dyak\GE20632
Curated drosophilid orthologs	Dpse\GA13427   Drep\ImpL2   Dsim\ImpL2 (Jagadeeshan and Singh, 2005.5.16)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL002130-PA Aedes aegypti (mosquito) AGAP003141-PA Anopheles gambiae (mosquito) XP_393019.2 Apis mellifera (honey bee) XP_001945022.1 Acyrthosiphon pisum (pea aphid) BGIBMGA008174-PA Bombyx mori (silk worm) CN04283 Caenorhabditis brenneri (small nematode) CBP33797 Caenorhabditis briggsae (nematode) CE02468 Caenorhabditis elegans (worm) CPIJ004285 Culex pipens (mosquito) RP28548 Caenorhabditis remanei (nematode) 330310 Daphnia pulex (daphnia) ENSECAP00000000743 Equus caballus (horse) 108898 Lottia gigantea (owl limpet) XP_001608198.1 Nasonia vitripennis (wasp) PHUM010283-PA Pediculus humanus (human body louse) PP14240 Pristionchus pacificus (nematode) XP_968759.1 Tribolium castaneum (red flour beetle) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10570 LH22340 ISCW011409 FBgn0237937 FBgn0212219 FBgn0199804 FBgn0083431 FBgn0168924 JGI_V11_330310 FBgn0076803 FBgn0150334 FBgn0139564 FBgn0123013 FBgn0106465 FBgn0100866 CPIJ004285 BGIBMGA008174 BGIBMGA008146 ACYPI005323 GB17369 AGAP003141 AAEL002130 PB22906 PHUM494500 GLEAN_15822
Stocks & Reagents
Stocks Listed in FlyBase ( 12 )
Bloomington	24219 w1118; Mi{ET1}ImpL2MB04721 15485 y1 w67c23; P{EPgy2}ImpL2EY00981 21213 y1 w67c23; P{EPgy2}ImpL2EY16442 14083 y1 w67c23; P{SUPor-P}ImpL2KG02223 ry506 35068 y1 w*; Mi{MIC}ImpL2MI01638/TM3, Sb1 Ser1
Harvard	- P{XP}ImpL2d00958 - P{XP}ImpL2d01988 - P{XP}ImpL2d02555 - P{XP}ImpL2d04726
VDRC	v106543 P{KK112218}VIE-260B v30930 w1118; P{GD6004}v30930 v30931 w1118; P{GD6004}v30931/TM3
Genomic Clones ( 2 )
	BACR39O11 BACR48M07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 115 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD07266 SD10052 SD23735
Other clones	DPiM_SD07266 DPiM_SD10052
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH28517 HL03495 LD05951 LP02202 LP05250 LP05494 LP06542 LP17313 LP18403 RE17601 RE23525 RE28685 RE31166 RE33618 RE42813 RE47021 RE61726 RE61839 RE66161 RE71728 RE72372 SD01074 SD08160 SD10085 SD12844 SD15047 SD16117 SD16751 SD17536 SD19661 SD20422 SD21355 SD22475 SD23202 SD24406 SD25754 SD25949 SD27466 SD27631 SD28195
Other clones	414 7830 29134 32491 33870 34060 36798 42045 61314 64096 79151 81377 107658.1 175059 177250 475300 524407 569718 Cauquenes_24_C05 CK01.29D.G3 CK01.33B.A2 CK01.44C.G1 CK01.80B.E11 CK01.108A.F5 CK01.141D.F12 CK01.142A.G6 Diego_25_H02 Dmel_neb_014235_0626_2063 EK028333 EK050928 EK059506 EK062120 EK070808 EK092123 EK104906 EK105738 EK107134 EK118559 EK142039 EK147713 EK148315 EK148410 EK164419 EK166360 EK186140 EK189635 EK209035 EK215119 EK244617 EK276244 EN00634 EN01103 EN03002 EN05334 FGM210C06 FGM311H06 IP07172 LP04033 Parral_28_F12 RP004107439 RP004124293 RP004202921 RP004261643 RP004314110 RP004332307 RP004352665 RP004371010 RP004405773 RP004501170 UUGC1120
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0001257 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38513
Antibody Information
	polyclonal (Garbe et al., 1993, Alic et al., 2011)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes. (Kliman and Eyre-Walker, 1998) Temporal profile of gene expression is altered in Eip74EF mutant background. (Fletcher and Thummel, 1995) Ecdysteroid-regulated gene. (Andres et al., 1993) Analysis of deficiency mutants for the ImpL2 locus revealed that ImpL2 is essential for viability and is maternally supplied. (Garbe et al., 1993) Encodes a transcript associated with membrane-bound polysomes in imaginal discs and expressed only in response to 20-hydroxyecdysone (20 HOE). Expression studied both in vitro and in vivo. A 'late' gene involved in the eversion to the exterior of the elongated regions of discs by means of local changes in cell shape (Osterbur, Fristrom, Natzle, Tojo and Fristrom, 1988).
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079197 NM_168069 NM_168070 RefSeq (Proteins) • NP_523921 NP_728960 NP_728961 DDBJ / EMBL / GenBank • AA246942 AAB59248 AAB59249 AAB59250 AAB59251 AAF47866 AAL25515 AAN11593 AAN11594 AAY56639 AI534445 AI543329 AW944490 AY060476 BG640000 BH840508 BI640744 CZ471921 CZ471922 CZ472550 CZ472883 CZ474093 CZ474477 CZ474478 CZ474585 CZ477375 CZ477853 DQ062766 L23066 Entrez Gene - A searchable database of RefSeq genes. • 38513 UniProtKB/Swiss-Prot • Q09024 UniProtKB/TrEMBL • Q3YMW0 Q24364 Q24365 Q24366
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Immunoglobulin subtype 2 (IPR003598) Immunoglobulin-like (IPR007110) Immunoglobulin-like fold (IPR013783) Immunoglobulin I-set (IPR013098)
Linkouts
	BioGRID - A database of protein and genetic interactions • 63991 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0001257 DroID - A comprehensive database of gene and protein interactions. • FBgn0001257 DRSC - Results from RNAi screens. • FBgn0001257 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001257 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15009-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0001257 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38513 InParanoid A subset of ortholog calls from InParanoid. • AAEL002130-PA Aedes aegypti (mosquito) AGAP003141-PA Anopheles gambiae (mosquito) XP_393019.2 Apis mellifera (honey bee) XP_001945022.1 Acyrthosiphon pisum (pea aphid) BGIBMGA008174-PA Bombyx mori (silk worm) CN04283 Caenorhabditis brenneri (small nematode) CBP33797 Caenorhabditis briggsae (nematode) CE02468 Caenorhabditis elegans (worm) CPIJ004285 Culex pipens (mosquito) RP28548 Caenorhabditis remanei (nematode) 330310 Daphnia pulex (daphnia) ENSECAP00000000743 Equus caballus (horse) 108898 Lottia gigantea (owl limpet) XP_001608198.1 Nasonia vitripennis (wasp) PHUM010283-PA Pediculus humanus (human body louse) PP14240 Pristionchus pacificus (nematode) XP_968759.1 Tribolium castaneum (red flour beetle) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/imp-l2 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38513 modMine - Data generated by the modENCODE project. • FBgn0001257 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV10570 LH22340 ISCW011409 FBgn0237937 FBgn0212219 FBgn0199804 FBgn0083431 FBgn0168924 JGI_V11_330310 FBgn0076803 FBgn0150334 FBgn0139564 FBgn0123013 FBgn0106465 FBgn0100866 CPIJ004285 BGIBMGA008174 BGIBMGA008146 ACYPI005323 GB17369 AGAP003141 AAEL002130 PB22906 PHUM494500 GLEAN_15822
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	CG15009 (Sun et al., 2010, Jagadeeshan and Singh, 2005, Keleman et al., 2009.8.5, Honegger et al., 2008, Cammarato et al., 2011) CT34862 (Hynes and Zhao, 2000) GH28 (Jagadeeshan and Singh, 2005) Imp-12 (Gibson and Schubiger, 2001) ImpL2 (Jordan et al., 2005, Terry et al., 2006, Slack et al., 2010, Sun et al., 2010, Hueber et al., 2007, Zeitouni et al., 2007, Cornman and Willis, 2008, Choksi et al., 2006, Harvey et al., 2008, Shalaby et al., 2009, Boltz and Carney, 2008, Grönke et al., 2010, Adryan et al., 2007, Alic et al., 2011) IMPL2 (Jasper et al., 2001, Sajid et al., 2011, Honegger et al., 2008) Imp-L2 (Honegger et al., 2003, Bayer et al., 1996, Fletcher and Thummel, 1995, Garbe et al., 1993, Andres et al., 1993, Arquier et al., 2007, Honegger et al., 2008, Hoshizaki and Gibbs, 2007, Arquier et al., 2008, Flaherty et al., 2009, Alic et al., 2011) IMP-L2 (Andersen et al., 2000, White et al., 1999, Halaby and Mornon, 1998, Fristrom and Fristrom, 1993, Flatt et al., 2008) ImpL-2 (Jagadeeshan and Singh, 2005.5.16, Jagadeeshan and Singh, 2005)
Name Synonym	Ecdysone-inducible gene L2 (Jordan et al., 2005, Terry et al., 2006, Hueber et al., 2007, Morozova et al., 2006, Cammarato et al., 2011) Imaginal morphogenesis protein-Late 2 (Honegger et al., 2008, Arquier et al., 2008, Alic et al., 2011) neural and ectodermal development factor (Garbe, 1994.6.23)
Secondary FlyBase IDs
References ( 65 )
Generate a list of	All references relating to this gene ( 65 )
List References by type	Research paper  ( 39 ) Supplementary material  ( 4 ) Review  ( 3 ) Personal communication to FlyBase  ( 4 ) Abstract  ( 2 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 3 ) Conference report  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Book  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 6 )
	Alic et al., 2011, Aging Cell 10(1): 137--147 Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor. [FBrf0212768] Sajid et al., 2011, J. Biol. Chem. 286(1): 661--673 Structural and Biological Properties of the Drosophila Insulin-like Peptide 5 Show Evolutionary Conservation. [FBrf0212648] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Grönke et al., 2010, PLoS Genet. 6(2): e1000857 Molecular evolution and functional characterization of Drosophila insulin-like peptides. [FBrf0210097] Slack et al., 2010, PLoS Genet. 6(3): e1000881 Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk. [FBrf0210418] Sun et al., 2010, Exp. Gerontol. 45(3): 243--251 Açai palm fruit (Euterpe oleracea Mart.) pulp improves survival of flies on a high fat diet. [FBrf0210041] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...