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Gene Dmel\inaD

General Information
Symbol	Dmel\inaD	Species	D. melanogaster
Name	inactivation no afterpotential D	Annotation symbol	CG3504
Feature type	protein_coding_gene	FlyBase ID	FBgn0001263
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map	2-101
Cytogenetic map	59B3-59B3	Sequence location	2R:18,743,211..18,746,317 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene inactivation no afterpotential D is referred to in FlyBase by the symbol Dmel\inaD (CG3504, FBgn0001263). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: photoreceptor activity; protein binding; myosin III binding; structural molecule activity. There is experimental evidence that it is involved in the biological process: phototransduction; detection of light stimulus involved in sensory perception; sensory perception of sound; cellular response to light stimulus; deactivation of rhodopsin mediated signaling. 23 alleles are reported. The phenotypes of these alleles are annotated with: photoreceptor; retina; photoreceptor cell; eye photoreceptor cell. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: PDZ domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed during late pupal stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye. Comments on Affy2 ProbeSet: ProbeSet 1638319_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of inaD. Gene sequence location is 2R:18743211..18746317.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	inaD (J.C. Hall) Semi-dominant mutant of visual physiology, such that the phenotype (re PDA) of heterozygote similar to that produced by other ina homozygotes; inaD homozygotes exhibit ERG response that decays to baseline during bright light stimulus, and off transient is absent.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 59B3-59B3   Limits computationally determined from genome sequence between P{PZ}blw03972 and P{EP}EP627
Experimentally Determined Cytological Location
Cytogenetic map Notes References 59B-59B     (Shieh, 1994.10.13) 58F1-60F1   (determined by in situ hybridisation)   (Zuker, 1992)
Experimentally Determined Recombination Data
Location	2-101
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\inaD for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) inaD-RA FBtr0071909  NM_166566   2295   674 inaD-RB FBtr0305132  NM_001259541   2331   686
Additional Transcript Data & Comments
Reported size (kB)	2 (northern blot) (Shieh and Niemeyer, 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein inaD-PA   FBpp0071820   74.3   674   8.45     NP_726260   AAF46915 inaD-PB   FBpp0293662   75.7   686   8.45     NP_001246470   AFH08223
Additional Polypeptide Data & Comments
Reported size (kDa)	674 (aa); 90 (kD observed); 80 (kD predicted) (Shieh and Niemeyer, 1995)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • PDZ domain (IPR001478) PDB - Protein Data Bank. An information portal to biological macromolecular structures • 1IHJ
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA567501   AA567782   AA697690   AA697708   AA697926   AA698315   AA698780   AE013599 AAF46915   AF245280 AAF81203   AE013599 AFH08223   AI062182   AI062974   AI106836   AI106855   AI109567   AI134172   AI134388   AI134655   AI134802   AI135072   AI135326   AI238952   AI292548   AI292731   AI388279   AI388676   AI388808   AI388821   AI389166   AI402764   AI402874   AI405060   AI405189   AI405230   AI405258   AI405314   AI405399   AI513313   AI513818   AI517027   BG633249   BI572901   BI572911   BI572914   BI593666   BI607751   BI632001   BI632048   BI632087   BT004473 AAO42637   BT120028   BT120056   CK135673   CO178856   CO189363   CO270794   CO284142   CO284502   CO310074   EC062175   EC064606   EC195360   EC198731   EC245051   EC246625   EL883723   EL886478   EL886538   EL886643   EL886699   U15803 AAC36490   Z50513
UniProtKB/Swiss-Prot	Q24008
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
expression microarray Stage Tissue/Position (including subcellular localization) Reference adult stage   eye   (Xu et al., 2004) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 13 -- 16   Bolwig organ   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference adult stage   adult head   (Shieh and Niemeyer, 1995)
Additional Descriptive Data
	inaD transcripts are detected in adult heads on northern blots. (Shieh and Niemeyer, 1995) Eye-enriched transcripts determined by ratio of expression level in wild-type heads. versus expression level in so heads. (Xu et al., 2004)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference adult stage   rhabdomere   (Shieh and Niemeyer, 1995) retina   (Shieh and Niemeyer, 1995) ocellus   (Shieh and Niemeyer, 1995) photoreceptor cell   (Shieh and Niemeyer, 1995) western blot Stage Tissue/Position (including subcellular localization) Reference adult stage   adult head   (Tian et al., 2013)
Additional Descriptive Data
	inaD protein is detected exclusively in the retina of the eye. It is expressed in photoreceptor cells and in the ocelli. In ultrathin sections of photoreceptor cells, most of the protein is associated with rhabdomeres. (Shieh and Niemeyer, 1995)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
inaD signaling complex inferred from physical interaction with inaC (Tsunoda et al., 1997) inferred from physical interaction with ninaE AND inferred from physical interaction with trp (Chevesich et al., 1997) inferred from physical interaction with norpA (Tsunoda et al., 1997) inferred from physical interaction with trp (Tsunoda et al., 1997) plasma membrane inferred from direct assay (Khanna et al., 2010) rhabdomere inferred from direct assay (Baehner et al., 2002, Wang et al., 2005, Sanxaridis and Tsunoda, 2010)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1.5 Larval Midgut    2.9 Larval Hindgut    0.9 Larval Malpighian Tubules    0.5 Larval Fat Body    1 Larval Salivary Gland    0.8 Larval Trachea    50.05 Larval Carcass    0.85 Adult Head    1090.8 Adult Eye    3889.3 Adult Brain    29.3 Adult Thoracic-Abdominal Ganglion    0.9 Adult Crop    1 Adult Midgut    0.8 Adult Hindgut    0.9 Adult Malpighian Tubules    1.3 Adult Fat Body    0.8 Adult Salivary Gland    2.2 Adult Heart    1.3 Adult VirginFemale Spermatheca    0.5 Adult InseminatedFemale Spermatheca    0.7 Adult Ovary    0.7 Adult Testis    1 Adult Male Accessory Gland    1 Adult Carcass    1.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    1.5 Larval Midgut    2.9 Larval Hindgut    0.9 Larval Malpighian Tubules    0.5 Larval Fat Body    1 Larval Salivary Gland    0.8 Larval Trachea    50.05 Larval Carcass    0.85 Adult Head  (1090.8) Adult Eye  (3889.3) Adult Brain    29.3 Adult Thoracic-Abdominal Ganglion    0.9 Adult Crop    1 Adult Midgut    0.8 Adult Hindgut    0.9 Adult Malpighian Tubules    1.3 Adult Fat Body    0.8 Adult Salivary Gland    2.2 Adult Heart    1.3 Adult VirginFemale Spermatheca    0.5 Adult InseminatedFemale Spermatheca    0.7 Adult Ovary    0.7 Adult Testis    1 Adult Male Accessory Gland    1 Adult Carcass    1.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    1.5 Larval Midgut    2.9 Larval Hindgut    0.9 Larval Malpighian Tubules    0.5 Larval Fat Body    1 Larval Salivary Gland    0.8 Larval Trachea    50.05 Larval Carcass    0.85 Adult Head  (1090.8) Adult Eye  (3889.3) Adult Brain    29.3 Adult Thoracic-Abdominal Ganglion    0.9 Adult Crop    1 Adult Midgut    0.8 Adult Hindgut    0.9 Adult Malpighian Tubules    1.3 Adult Fat Body    0.8 Adult Salivary Gland    2.2 Adult Heart    1.3 Adult VirginFemale Spermatheca    0.5 Adult InseminatedFemale Spermatheca    0.7 Adult Ovary    0.7 Adult Testis    1 Adult Male Accessory Gland    1 Adult Carcass    1.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1.5 Larval Midgut    2.9 Larval Hindgut    0.9 Larval Malpighian Tubules    0.5 Larval Fat Body    1 Larval Salivary Gland    0.8 Larval Trachea    50.05 Larval Carcass    0.85 Adult Head    1090.8 Adult Eye    3889.3 Adult Brain    29.3 Adult Thoracic-Abdominal Ganglion    0.9 Adult Crop    1 Adult Midgut    0.8 Adult Hindgut    0.9 Adult Malpighian Tubules    1.3 Adult Fat Body    0.8 Adult Salivary Gland    2.2 Adult Heart    1.3 Adult VirginFemale Spermatheca    0.5 Adult InseminatedFemale Spermatheca    0.7 Adult Ovary    0.7 Adult Testis    1 Adult Male Accessory Gland    1 Adult Carcass    1.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1.5 Larval Midgut    2.9 Larval Hindgut    0.9 Larval Malpighian Tubules    0.5 Larval Fat Body    1 Larval Salivary Gland    0.8 Larval Trachea    50.05 Larval Carcass    0.85 Adult Head    1090.8 Adult Eye    3889.3 Adult Brain    29.3 Adult Thoracic-Abdominal Ganglion    0.9 Adult Crop    1 Adult Midgut    0.8 Adult Hindgut    0.9 Adult Malpighian Tubules    1.3 Adult Fat Body    0.8 Adult Salivary Gland    2.2 Adult Heart    1.3 Adult VirginFemale Spermatheca    0.5 Adult InseminatedFemale Spermatheca    0.7 Adult Ovary    0.7 Adult Testis    1 Adult Male Accessory Gland    1 Adult Carcass    1.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    1.5 Larval Midgut    2.9 Larval Hindgut    0.9 Larval Malpighian Tubules    0.5 Larval Fat Body    1 Larval Salivary Gland    0.8 Larval Trachea    50.05 Larval Carcass    0.85 Adult Head  (1090.8) Adult Eye  (3889.3) Adult Brain    29.3 Adult Thoracic-Abdominal Ganglion    0.9 Adult Crop    1 Adult Midgut    0.8 Adult Hindgut    0.9 Adult Malpighian Tubules    1.3 Adult Fat Body    0.8 Adult Salivary Gland    2.2 Adult Heart    1.3 Adult VirginFemale Spermatheca    0.5 Adult InseminatedFemale Spermatheca    0.7 Adult Ovary    0.7 Adult Testis    1 Adult Male Accessory Gland    1 Adult Carcass    1.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    1.5 Larval Midgut    2.9 Larval Hindgut    0.9 Larval Malpighian Tubules    0.5 Larval Fat Body    1 Larval Salivary Gland    0.8 Larval Trachea    50.05 Larval Carcass    0.85 Adult Head  1090.8 Adult Eye  (3889.3) Adult Brain    29.3 Adult Thoracic-Abdominal Ganglion    0.9 Adult Crop    1 Adult Midgut    0.8 Adult Hindgut    0.9 Adult Malpighian Tubules    1.3 Adult Fat Body    0.8 Adult Salivary Gland    2.2 Adult Heart    1.3 Adult VirginFemale Spermatheca    0.5 Adult InseminatedFemale Spermatheca    0.7 Adult Ovary    0.7 Adult Testis    1 Adult Male Accessory Gland    1 Adult Carcass    1.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1.5 Larval Midgut    2.9 Larval Hindgut    0.9 Larval Malpighian Tubules    0.5 Larval Fat Body    1 Larval Salivary Gland    0.8 Larval Trachea    50.05 Larval Carcass    0.85 Adult Head    1090.8 Adult Eye    3889.3 Adult Brain    29.3 Adult Thoracic-Abdominal Ganglion    0.9 Adult Crop    1 Adult Midgut    0.8 Adult Hindgut    0.9 Adult Malpighian Tubules    1.3 Adult Fat Body    0.8 Adult Salivary Gland    2.2 Adult Heart    1.3 Adult VirginFemale Spermatheca    0.5 Adult InseminatedFemale Spermatheca    0.7 Adult Ovary    0.7 Adult Testis    1 Adult Male Accessory Gland    1 Adult Carcass    1.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1090.8   NA  Eye    3889.3   NA  Brain    29.3   1.5  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    0.9   NA  Crop    1   2.9  Midgut    0.8   0.9  Hindgut    0.9   0.5  Malpighian Tubules    1.3   1  Fat Body    0.8   0.8  Salivary Gland    2.2   NA  Heart    1.3   no informative data  Trachea    NA   NA  VirginFemale Spermatheca    0.5   NA  InseminatedFemale Spermatheca    0.7   NA  Ovary    0.7   NA  Testis    1   NA  Male Accessory Gland    1   0.85  Carcass    1.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    2 head, virgin 1-day female    194 head, virgin 4-day female    168 head, virgin 20-day female    124 head, mated 1-day female    166 head, mated 4-day female    129 head, mated 20-day female    98 head, mated 1-day male    261 head, mated 4-day male    204 head, mated 20-day male    198 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    2 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    2 head, virgin 1-day female  (194) head, virgin 4-day female  (168) head, virgin 20-day female  (124) head, mated 1-day female  (166) head, mated 4-day female  (129) head, mated 20-day female  (98) head, mated 1-day male  (261) head, mated 4-day male  (204) head, mated 20-day male  (198) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    2 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    2 head, virgin 1-day female  (194) head, virgin 4-day female  (168) head, virgin 20-day female  (124) head, mated 1-day female  (166) head, mated 4-day female  (129) head, mated 20-day female    98 head, mated 1-day male  (261) head, mated 4-day male  (204) head, mated 20-day male  (198) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    2 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    2 head, virgin 1-day female    194 head, virgin 4-day female    168 head, virgin 20-day female    124 head, mated 1-day female    166 head, mated 4-day female    129 head, mated 20-day female    98 head, mated 1-day male    261 head, mated 4-day male    204 head, mated 20-day male    198 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    2 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    2 head, virgin 1-day female    194 head, virgin 4-day female    168 head, virgin 20-day female    124 head, mated 1-day female    166 head, mated 4-day female    129 head, mated 20-day female    98 head, mated 1-day male    261 head, mated 4-day male    204 head, mated 20-day male    198 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    2 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    2 head, virgin 1-day female  (194) head, virgin 4-day female  (168) head, virgin 20-day female  (124) head, mated 1-day female  (166) head, mated 4-day female  (129) head, mated 20-day female  (98) head, mated 1-day male  (261) head, mated 4-day male  (204) head, mated 20-day male  (198) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    2 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    2 head, virgin 1-day female  (194) head, virgin 4-day female  (168) head, virgin 20-day female  124 head, mated 1-day female  (166) head, mated 4-day female  129 head, mated 20-day female    98 head, mated 1-day male  (261) head, mated 4-day male  (204) head, mated 20-day male  (198) salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    2 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    0 central nervous system, pupae P8    2 head, virgin 1-day female    194 head, virgin 4-day female    168 head, virgin 20-day female    124 head, mated 1-day female    166 head, mated 4-day female    129 head, mated 20-day female    98 head, mated 1-day male    261 head, mated 4-day male    204 head, mated 20-day male    198 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    2 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    0 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed during late pupal stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    3 embryo 08-10hr    3 embryo 10-12hr    2 embryo 12-14hr    2 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    13 pupae 3d postWPP    39 pupae 4d postWPP    52 adult male 01day    57 adult male 05day    65 adult male 30day    86 adult female 01day    34 adult female 05day    13 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    3 embryo 08-10hr    3 embryo 10-12hr    2 embryo 12-14hr    2 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    13 pupae 3d postWPP  (39) pupae 4d postWPP  (52) adult male 01day  (57) adult male 05day  (65) adult male 30day  (86) adult female 01day  (34) adult female 05day    13 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    3 embryo 08-10hr    3 embryo 10-12hr    2 embryo 12-14hr    2 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    13 pupae 3d postWPP    39 pupae 4d postWPP    52 adult male 01day    57 adult male 05day    65 adult male 30day    86 adult female 01day    34 adult female 05day    13 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    3 embryo 08-10hr    3 embryo 10-12hr    2 embryo 12-14hr    2 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    13 pupae 3d postWPP    39 pupae 4d postWPP    52 adult male 01day    57 adult male 05day    65 adult male 30day    86 adult female 01day    34 adult female 05day    13 adult female 30day    14 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    3 embryo 08-10hr    3 embryo 10-12hr    2 embryo 12-14hr    2 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    13 pupae 3d postWPP    39 pupae 4d postWPP    52 adult male 01day    57 adult male 05day    65 adult male 30day    86 adult female 01day    34 adult female 05day    13 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    3 embryo 08-10hr    3 embryo 10-12hr    2 embryo 12-14hr    2 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    13 pupae 3d postWPP  (39) pupae 4d postWPP  (52) adult male 01day  (57) adult male 05day  (65) adult male 30day  (86) adult female 01day  (34) adult female 05day    13 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    3 embryo 08-10hr    3 embryo 10-12hr    2 embryo 12-14hr    2 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    13 pupae 3d postWPP    39 pupae 4d postWPP    52 adult male 01day    57 adult male 05day    65 adult male 30day    86 adult female 01day    34 adult female 05day    13 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    1 embryo 04-06hr    1 embryo 06-08hr    3 embryo 08-10hr    3 embryo 10-12hr    2 embryo 12-14hr    2 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    13 pupae 3d postWPP    39 pupae 4d postWPP    52 adult male 01day    57 adult male 05day    65 adult male 30day    86 adult female 01day    34 adult female 05day    13 adult female 30day    14 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    1 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    8 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    8 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    8 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    8 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    8 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    8 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    8 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    12 cold shock, 4-day adult    8 heat shock, 4-day adult    7 Cadmium 50 mM 6 hrs, larvae L3    0 Cadmium 50 mM 12 hrs, larvae L3    0 Cadmium 50 mM 48 hrs, 4-day adult    4 Cadmium 100 mM 48 hrs, 4-day adult    11 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    12 Zinc 5 mM 12 hrs, larvae L3    0 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    15 Ethanol 5% 3 hrs, larvae L3    0 Ethanol 10% 3 hrs, larvae L3    0 Caffeine 1.5 mg/ml 4 hrs, larvae L3    0 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    11 Caffeine 25 mg/ml 48 hrs, 4-day adult    8 Paraquat 5 mM 48 hrs, 4-day adult    17 Paraquat 10 mM 48 hrs, 4-day adult    23 Rotenone 2 μg 12 hrs, larvae L3    0 Rotenone 8 μg 12 hrs, larvae L3    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_00
External Data & Images
Linkouts	BDGP expression data • RH58949 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001263 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3504-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for inaD Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 inaDGD10989 Other Phenotypes Allele auditory perception defective | adult stage inaDT1 neurophysiology defective inaDP215 inaDT1 inaDT2 neurophysiology defective, with inaDC645S.ninaE inaDT1 neurophysiology defective, with inaDT1 inaDC645S.ninaE neurophysiology defective | adult stage inaDT1 neurophysiology defective | adult stage (with inaDninaE.T669A) inaDT1 neurophysiology defective | adult stage (with inaDT1) inaDninaE.T669A phototaxis defective | adult stage inaDunspecified visual behavior defective inaDP215 inaDT1 inaDT2 visual behavior defective, with inaDC645S.ninaE inaDT1 visual behavior defective, with inaDT1 inaDC645S.ninaE visual behavior defective | dominant inaDP215 visual behavior defective | recessive inaDP215 inaDT1 inaDT2 wild-type inaDhs.PT Phenotype manifest in Allele eye photoreceptor cell inaDT1 inaDT2 eye photoreceptor cell, with inaDC645S.ninaE inaDT1 eye photoreceptor cell, with inaDT1 inaDC645S.ninaE photoreceptor inaDT1 inaDT2 photoreceptor | adult stage (with inaDninaE.T669A) inaDT1 photoreceptor | adult stage (with inaDT1) inaDninaE.T669A photoreceptor cell inaDP215 retina inaDP215
Classical Alleles ( 7 )
For All Classical Alleles Show
Allele of inaD Class Mutagen Stocks Known lesion inaDP215 ethyl methanesulfonate 1 Yes inaDsu100 ethyl methanesulfonate 0 Yes inaDsu1 ethyl methanesulfonate 0 Yes inaDT1 ethyl methanesulfonate 0 Yes inaDT2 ethyl methanesulfonate 0 Yes inaDttd10 FLPase 0 -- inaDunspecified 0 --
Alleles Carried on Transgenic Constructs ( 16 )
For All Alleles Carried on Transgenic Constructs Show
Allele of inaD Class Mutagen Stocks Known lesion inaDGD10989 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes inaDC645S.ninaE in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes inaDdsRNA.cRa in vitro construct - RNAi 0 Yes inaDGMR.PT in vitro construct - regulatory fusion 0 Yes inaDGMR.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes inaDhs.PS in vitro construct - regulatory fusion 0 Yes inaDhs.PT in vitro construct - regulatory fusion 0 Yes inaDninaE.PM in vitro construct - regulatory fusion 0 Yes inaDninaE.T669A in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes inaDninaE in vitro construct - regulatory fusion 0 Yes inaDPDZ1.GMR in vitro construct - amino acid replacement in vitro construct - regulatory fusion 0 Yes inaDPDZ123.GMR.T:Btau\1D4 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes inaDPDZ2.GMR in vitro construct - amino acid replacement in vitro construct - regulatory fusion 0 Yes inaDPDZ3.GMR in vitro construct - amino acid replacement in vitro construct - regulatory fusion 0 Yes inaDPDZ4.GMR in vitro construct - amino acid replacement in vitro construct - regulatory fusion 0 Yes inaDPDZ5.GMR in vitro construct - amino acid replacement in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)59AD (Georgiev et al., 2005)
Not disrupted in	Df(2R)3-70 (Georgiev et al., 2005) Df(2R)59AB (Georgiev et al., 2005)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data heat-shock construct P{hs-inaD.T} NA P{hsp70-InsD} NA UAS construct P{GD10989} NA characterization construct P{GMR-inaD.GFP} NA P{GMR-inaD.PDZ1} NA P{GMR-inaD.PDZ2} NA P{GMR-inaD.PDZ3} NA P{GMR-inaD.PDZ4} NA P{GMR-inaD.PDZ5} NA P{GMR-inaD.PDZ123-1D4} NA P{GMR-inaD.T} NA P{ninaE-inaD.C645S} NA P{ninaE-inaD.T669A} NA P{ninaE-inaD.WT} NA P{ninaE-inaD.Z} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 16 unique terms )
Terms Based on Experimental Evidence ( 12 terms )
Molecular Function
CV term Evidence References
myosin III binding inferred from physical interaction with ninaC (Wes et al., 1999) photoreceptor activity inferred from mutant phenotype (Liu et al., 2011) protein binding inferred from physical interaction with UniProtKB:P13677 (assigned by UniProtKB) (Kumar and Shieh, 2001) structural molecule activity inferred from direct assay AND inferred from mutant phenotype (Shieh et al., 1997) inferred from mutant phenotype (Tsunoda et al., 1997)
Biological Process
CV term Evidence References
cellular response to light stimulus inferred from mutant phenotype (Liu et al., 2011) deactivation of rhodopsin mediated signaling inferred from mutant phenotype (Shieh and Niemeyer, 1995) detection of light stimulus involved in sensory perception inferred from mutant phenotype (Popescu et al., 2006) phototransduction inferred from mutant phenotype (Shieh and Niemeyer, 1995, Tsunoda et al., 1997) inferred from physical interaction with trp (Shieh and Zhu, 1996) sensory perception of sound inferred from mutant phenotype (Senthilan et al., 2012)
Cellular Component
CV term Evidence References
inaD signaling complex inferred from physical interaction with inaC (Tsunoda et al., 1997) inferred from physical interaction with ninaE AND inferred from physical interaction with trp (Chevesich et al., 1997) inferred from physical interaction with norpA (Tsunoda et al., 1997) inferred from physical interaction with trp (Tsunoda et al., 1997) plasma membrane inferred from direct assay (Khanna et al., 2010) rhabdomere inferred from direct assay (Baehner et al., 2002, Wang et al., 2005, Sanxaridis and Tsunoda, 2010)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
calmodulin binding traceable author statement (Hardie, 2001, Montell, 1999) myosin binding traceable author statement (Hardie, 2001) receptor signaling complex scaffold activity traceable author statement (Hardie, 2001)
Biological Process
CV term Evidence References
phototransduction non-traceable author statement (Montell, 1999) protein localization traceable author statement (Hardie, 2001)
Cellular Component
CV term Evidence References
inaD signaling complex traceable author statement (Montell, 1999, Harteneck, 2003)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
inaD - inaF-B anti bait coimmunoprecipitation, anti tag western blot, anti tag coimmunoprecipitation, western blot (Cheng and Nash, 2007)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions inaD allele Gene References inaD1 trpl (Leung et al., 2000)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63241 DroID - A comprehensive database of gene and protein interactions. • FBgn0001263 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37629 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q24008
Orthologs
OrthoDB Orthologs (21) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6MW8RQ Dipteran inclusive ortholog search EOG6XKVG7 Insect inclusive ortholog search EOG6H18RZ Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG6MW8RQ)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\inaD     Drosophila simulans   Dsim\GD25102 Y   Drosophila sechellia   Dsec\GM15606 Y   Drosophila erecta   Dere\GG20089 Y   Drosophila yakuba   Dyak\GE11628 Y   Drosophila ananassae   Dana\GF11324 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA17487 Y   Drosophila persimilis   Dper\GL10199 Y   Drosophila willistoni   Dwil\GK20857 Y   Drosophila virilis   Dvir\GJ19956 Y   Drosophila mojavensis   Dmoj\GI18992 Y   Drosophila grimshawi   Dgri\GH20094 Y
Orthologs in non-Drosophila Dipterans (EOG6XKVG7)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL008075   Anopheles gambiae Malaria mosquito  Agam\AGAP002145
Orthologs in non-Dipteran Insects (EOG6H18RZ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH26828   Atta cephalotes Leafcutter ant  Acep\ACEP17899   Atta cephalotes Leafcutter ant  Acep\ACEP17898   Camponotus floridanus Florida carpenter ant  Cflo\CFLO12826   Linepithema humile Argentine ant  Lhum\LH11902   Solenopsis invicta Red fire ant  Sinv\SINV17257   Bombyx mori Silkmoth  Bmor\BGIBMGA013979
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD25102 Drosophila sechellia Dsec\GM15606 Drosophila erecta Dere\GG20089 Drosophila yakuba Dyak\GE11628 Drosophila ananassae Dana\GF11324 Drosophila pseudoobscura pseudoobscura Dpse\GA17487 Drosophila persimilis Dper\GL10199 Drosophila willistoni Dwil\GK20857 Drosophila virilis Dvir\GJ19956 Drosophila mojavensis Dmoj\GI18992 Drosophila grimshawi Dgri\GH20094
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	42242 w*; inaDP215
VDRC	v26211 w1118; P{GD10989}v26211/CyO
Genomic Clones ( 1 )
	BACR09K23 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 64 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RH58949
Other clones	MIP15186 MIP15238
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH01296 GH02368 GH06072 GH06101 GH08793 GH11552 GH11841 GH12178 GH12351 GH12693 GH13013 GH14605 GH15105 GH15474 GH15701 GH19116 GH19646 GH19827 GH19845 GH20270 GH22052 GH22204 GH23047 GH24971 GH25124 GH25170 GH25208 GH25275 GH25387 GH26918 GH27648 HL01354 HL01762 HL02990 HL03469 HL04263 HL05676 RH06481 RH07008 RH07134 RH56642 RH61113 RH72474
Other clones	18677 37922 46510 64597 97711 CK01.54A.F4 EK044054 EK057809 EK100304 EK165346 EK166205 EK220362 HL03019 IP13380 IP17717 IP17817 IP17917 RH07612
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0001263 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37629
Antibody Information
	polyclonal (Shieh and Niemeyer, 1995, Wes et al., 1999)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) The trp-inaD protein-protein interaction is required for maintaining transduction complexes in the rhabdomeres. (Tsunoda et al., 2001) The fact that the ability of non-inaD bound trp to contribute to photoreceptor responses depends on the presence of trpl suggests that there may be interactions between trpl and the non-inaD-bound trp protein. (Leung et al., 2000) inaD protein is required for retention rather than targetting of trp protein to rhabdomeres. (Li and Montell, 2000) The second PDZ domain of inaD protein interacts with the last three residues in the carboxyl-terminal tail of inaC protein. (Adamski et al., 1998) inaD functions as a master scaffold for subcellular compartmentalization of the phototransduction machinery. (Scott and Zuker, 1998) inaD protein binds directly to norpA protein via two terminally positioned PDZ1 and PDZ5 domains. PDZ1 binds to the C-terminus of norpA, while PDZ5 binds to an internal region overlapping with the G-box homology region. (van Huizen et al., 1998) A PDZ domain is required in vivo for anchoring an ion channel to its normal subcellular site: inaD is required for spatially localising trp to a large signalling complex. (Chevesich et al., 1997) A novel tripeptide motif in the C terminus of norpA associates with inaD. Expression of transgenic norpA that displays no interaction with inaD reveals abnormal ERG with slow kinetics suggesting the association between inaD and norpA is important in the regulation of activation and deactivation of visual transduction. (Shieh et al., 1997) The inaD protein is composed of five distinct PDZ domains and acts as an organising scaffold for photoreceptor signalling complexes in vivo. (Tsunoda et al., 1997) Antibodies to the inaD protein co-precipitate trp gene product. The interaction has been mapped to the 19 amino acid C-terminus of trp and the PDZ domain of inaD. inaD functions as a regulatory subunit of the trp Ca2+ channel. (Shieh and Zhu, 1996) Mutations in inaD suggest that inaD is involved in the negative feedback regulation of the light-activated signaling cascade in photoreceptors. (Shieh and Niemeyer, 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_166566 NM_001259541 RefSeq (Proteins) • NP_726260 NP_001246470 DDBJ / EMBL / GenBank • AA567782 AA697690 AAC36490 AAF46915 AAF81203 AAO42637 AF245280 AFH08223 BI632048 BT004473 U15803 Z50513 Entrez Gene - A searchable database of RefSeq genes. • 37629 UniProtKB/Swiss-Prot • Q24008
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • PDZ domain (IPR001478) PDB - Protein Data Bank. An information portal to biological macromolecular structures • 1IHJ BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RH58949
Linkouts
	BioGRID - A database of protein and genetic interactions • 63241 DroID - A comprehensive database of gene and protein interactions. • FBgn0001263 DRSC - Results from RNAi screens. • FBgn0001263 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001263 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3504-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0001263 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37629 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /hjmuller/inad1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37629 modMine - Data generated by the modENCODE project. • FBgn0001263 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • Q24008
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	CG3504 (Juhola et al., 2000, Roos et al., 2005, Khanna et al., 2010) InaD (Pedra et al., 2004, Delmas et al., 2004, Hardie, 2001, Kimple et al., 2001, Leung et al., 2000, Jaken, 2000, Shieh, 1994.10.13, Montell, 1998, van Huizen et al., 1998, Ponting et al., 1997, Clapham, 1996, Shieh and Zhu, 1996, Pak, 1995, Fichelson et al., 2012, Henderson et al., 2000, Xiong et al., 2012, Georgiev et al., 2005) INAD (Dan et al., 2001, Lee and Montell, 2001, Hardie and Raghu, 2001, Xu et al., 1998, Richter et al., 2005, Han et al., 2006, Kwon and Montell, 2006, Wang et al., 2008, Mecklenburg et al., 2010, Wang et al., 2005, Wang et al., 2008, Wes et al., 1999, Han et al., 2007, Su et al., 2003, Dasgupta et al., 2009, Wang et al., 2010, Sanxaridis and Tsunoda, 2010, Peng et al., 2008, Cao et al., 2011, Hu et al., 2012, Tian et al., 2013) Ina-D (Burack and Shaw, 2000) inaD (Yang et al., 2005, Hiesinger et al., 2006, Yao and Carlson, 2010, Chorna-Ornan et al., 2005, Sanxaridis et al., 2007, Nelson et al., 2005, Liu et al., 2011, Mishra et al., 2007, Wes et al., 1999, Meyer et al., 2006, Popescu et al., 2006, Zelhof et al., 2003, Landry et al., 2007, Mendoza-Topaz et al., 2008, Cook, 2010.2.24, Meyer et al., 2008, Cheng and Nash, 2007, Peng et al., 2008, Sanxaridis and Tsunoda, 2010, Venkatachalam et al., 2010, Taraszka et al., 2005, Lieu et al., 2012, Senthilan et al., 2012)
Name Synonym	inactivation, no after-depolarization (Henderson et al., 2000) inactivation no afterpotential D (Wang et al., 2008, Harbison et al., 2005) inactivation-no after potential D (Su et al., 2003) Inactivation no afterpotential D (Khanna et al., 2010) inactivation-no-afterpotential-D (Sanxaridis and Tsunoda, 2010) inactivation-no-afterpotential D (Peng et al., 2008) INAD (Wang et al., 2008)
Secondary FlyBase IDs
References ( 149 )
Generate a list of	All references relating to this gene ( 149 )
List References by type	Research paper  ( 78 ) Supplementary material  ( 7 ) Review  ( 50 ) Personal communication to FlyBase  ( 4 ) Abstract  ( 5 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 10 )
	Tian et al., 2013, Neuron 77(2): 311--322 Neurexin Regulates Visual Function via Mediating Retinoid Transport to Promote Rhodopsin Maturation. [FBrf0220614] Fichelson et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(20): 7893--7898 Orthodenticle and Kruppel homolog 1 regulate Drosophila photoreceptor maturation. [FBrf0218313] Hardie and Franze, 2012, Science 338(6104): 260--263 Photomechanical responses in Drosophila photoreceptors. [FBrf0219673] Hu et al., 2012, J. Biol. Chem. 287(17): 13911--13918 Protein gq modulates termination of phototransduction and prevents retinal degeneration. [FBrf0218114] Krauchunas et al., 2012, Dev. Biol. 370(1): 125--134 Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster. [FBrf0219342] Lieu et al., 2012, PLoS ONE 7(2): e31622 Mechanisms Underlying Stage-1 TRPL Channel Translocation in Drosophila Photoreceptors. [FBrf0217631] Senthilan et al., 2012, Cell 150(5): 1042--1054 Drosophila auditory organ genes and genetic hearing defects. [FBrf0219321] Xiong et al., 2012, PLoS Biol. 10(12): e1001438 Crag Is a GEF for Rab11 Required for Rhodopsin Trafficking and Maintenance of Adult Photoreceptor Cells. [FBrf0220111] Cao et al., 2011, EMBO J. 30(18): 3701--3713 A Drosophila metallophosphoesterase mediates deglycosylation of rhodopsin. [FBrf0215269] Liu et al., 2011, Cell 145(7): 1088--1101 The INAD Scaffold Is a Dynamic, Redox-Regulated Modulator of Signaling in the Drosophila Eye. [FBrf0214003] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...