A Database of Drosophila Genes & Genomes

FB2012_01, released January 20th, 2012
 

Gene Dmel\inaD

General Information
SymbolDmel\inaDSpeciesD. melanogaster
Nameinactivation no afterpotential DAnnotation symbolCG3504
Feature typeprotein_coding_geneFlyBase IDFBgn0001263
Gene Model StatusCurrent Stock availability 1 publicly available
Genomic Location
Chromosome (arm)2RRecombination map2-101
Cytogenetic map59B3-59B3Sequence location2R:18,743,211..18,746,317 [-]

Genomic Maps

GBrowse View Help
modENCODE GBrowse
detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
The gene inactivation no afterpotential D is referred to in FlyBase by the symbol Dmel\inaD (CG3504, FBgn0001263). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; myosin III binding; structural molecule activity. There is experimental evidence that it is involved in the biological process: phototransduction; detection of light stimulus involved in sensory perception; deactivation of rhodopsin mediated signaling. 20 alleles are reported. The phenotypes of these alleles are annotated with: photoreceptor; retina; photoreceptor cell; eye photoreceptor cell. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: PDZ/DHR/GLGF. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed during late pupal stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye. Comments on Affy2 ProbeSet: ProbeSet 1638319_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of inaD. Gene sequence location is 2R:18743211..18746317.

External Summaries
hide Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage
inaD (J.C. Hall)
Semi-dominant mutant of visual physiology, such that the phenotype (re PDA) of heterozygote similar to that produced by other ina homozygotes; inaD homozygotes exhibit ERG response that decays to baseline during bright light stimulus, and off transient is absent.
hide Recent Updates
Description
What does this section display?
This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
Update Feed
Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01
References
Sequence features
FB2011_10
All updates Click here to see a list of all updates to this record from FB2010_08 and on.
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
59B3-59B3  
Limits computationally determined from genome sequence between P{PZ}blw03972 and P{EP}EP627  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
59B-59B  
58F1-60F1  
(determined by in situ hybridisation)  
Experimentally Determined Recombination Data
Location
2-101
 
Left of (cM)
Right of (cM)
Notes
hide Gene Model & Products
Please see the GBrowse view of Dmel\inaD for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
detailed view FBtr0071910 FBtr0071897 FBtr0071909 FBtr0305132 FBpp0071821 FBpp0071808 FBpp0293662 FBpp0071820 FBti0041548 FBti0026423
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
FBtr0071909
  2295
  674
FBtr0305132
 
  2331
  686
Additional Transcript Data & Comments
Reported size (kB)
2 (northern blot)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
FBpp0071820  
74.3  
674  
8.45  
FBpp0293662  
75.7  
686  
8.45  
 
 
Additional Polypeptide Data & Comments
Reported size (kDa)
674 (aa); 90 (kD observed); 80 (kD predicted)
Comments
External Data
Linkouts
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
PDZ/DHR/GLGF (IPR001478)
PDB - Protein Data Bank. An information portal to biological macromolecular structures
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
hide Mapped Features
Mapped Features have been reorganized, please see this article for details.
Additional mapped features and mutations can be found on GBrowse or related reports.
Type
Symbol & Location
Additional Notes
References
hide External Data
Linkouts
Crossreferences
hide Expression Data
hideTranscript Expression
expression microarray
Stage
Tissue/Position (including subcellular localization)
Reference
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
inaD transcripts are detected in adult heads on northern blots.
Eye-enriched transcripts determined by ratio of expression level in wild-type heads. versus expression level in so heads.
Marker for
Subcellular Localization
CV Term
Notes
hidePolypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
inaD protein is detected exclusively in the retina of the eye. It is expressed in photoreceptor cells and in the ocelli. In ultrathin sections of photoreceptor cells, most of the protein is associated with rhabdomeres.
Marker for
Subcellular Localization
CV Term
Notes
hide High-Throughput Expression Data
or
Untitled Document detailed view RpL23-RA inaD-RA inaD-RB
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

modENCODE Temporal Expression Data for FBgn0001263


   Styles
Linear
Logarithmic
Heatmap
   Scales
max expr for FBgn0001263
Very low expression bin max
Moderate expression bin max
High expression bin max
Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of extremely low expression. Peak expression observed during late pupal stages, in adult male stages.
[download data (TSV)]

Guide to modENCODE expression level colors
 
No expression (0 - 0)
 
Extremely low expression (1 - 10)
 
Very low expression (11 - 100)
 
Low expression (101 - 400)
 
Moderate expression (401 - 1400)
 
Moderately high expression (1401 - 4000)
 
High expression (4001 - 10000)
 
Very high expression (10001 - 100000)
 
Extremely high expression (100001 - 2000000)

Linear, scaled to maximum FBgn0001263 expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 6
embryo 02-04hr
 
 42
embryo 04-06hr
 
 70
embryo 06-08hr
 
 225
embryo 08-10hr
 
 201
embryo 10-12hr
 
 160
embryo 12-14hr
 
 104
embryo 14-16hr
 
 92
embryo 16-18hr
 
 61
embryo 18-20hr
 
 54
embryo 20-22hr
 
 61
embryo 22-24hr
 
 56
larva L1
 
 88
larva L2
 
 27
larva L3 12hr old
 
 19
larva L3 puffstage 1-2
 
 8
larva L3 puffstage 3-6
 
 23
larva L3 puffstage 7-9
 
 20
white prepupae new
 
 43
white prepupae 12hr
 
 67
white prepupae 24hr
 
 34
pupae 2d postWPP
 
 1010
pupae 3d postWPP
 
 3004
pupae 4d postWPP
 
 4041
adult male 01day
 
 4391
adult male 05day
 
 5037
adult male 30day
 
 6633
adult female 01day
 
 2587
adult female 05day
 
 952
adult female 30day
 
 1084
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
Linear, scaled to Very low expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 6
embryo 02-04hr
 
 42
embryo 04-06hr
 
 70
embryo 06-08hr
 (225)
embryo 08-10hr
 (201)
embryo 10-12hr
 (160)
embryo 12-14hr
 104
embryo 14-16hr
 
 92
embryo 16-18hr
 
 61
embryo 18-20hr
 
 54
embryo 20-22hr
 
 61
embryo 22-24hr
 
 56
larva L1
 
 88
larva L2
 
 27
larva L3 12hr old
 
 19
larva L3 puffstage 1-2
 
 8
larva L3 puffstage 3-6
 
 23
larva L3 puffstage 7-9
 
 20
white prepupae new
 
 43
white prepupae 12hr
 
 67
white prepupae 24hr
 
 34
pupae 2d postWPP
 (1010)
pupae 3d postWPP
 (3004)
pupae 4d postWPP
 (4041)
adult male 01day
 (4391)
adult male 05day
 (5037)
adult male 30day
 (6633)
adult female 01day
 (2587)
adult female 05day
 (952)
adult female 30day
 (1084)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
Linear, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 6
embryo 02-04hr
 
 42
embryo 04-06hr
 
 70
embryo 06-08hr
 
 225
embryo 08-10hr
 
 201
embryo 10-12hr
 
 160
embryo 12-14hr
 
 104
embryo 14-16hr
 
 92
embryo 16-18hr
 
 61
embryo 18-20hr
 
 54
embryo 20-22hr
 
 61
embryo 22-24hr
 
 56
larva L1
 
 88
larva L2
 
 27
larva L3 12hr old
 
 19
larva L3 puffstage 1-2
 
 8
larva L3 puffstage 3-6
 
 23
larva L3 puffstage 7-9
 
 20
white prepupae new
 
 43
white prepupae 12hr
 
 67
white prepupae 24hr
 
 34
pupae 2d postWPP
 
 1010
pupae 3d postWPP
 (3004)
pupae 4d postWPP
 (4041)
adult male 01day
 (4391)
adult male 05day
 (5037)
adult male 30day
 (6633)
adult female 01day
 (2587)
adult female 05day
 
 952
adult female 30day
 
 1084
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
Linear, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 6
embryo 02-04hr
 
 42
embryo 04-06hr
 
 70
embryo 06-08hr
 
 225
embryo 08-10hr
 
 201
embryo 10-12hr
 
 160
embryo 12-14hr
 
 104
embryo 14-16hr
 
 92
embryo 16-18hr
 
 61
embryo 18-20hr
 
 54
embryo 20-22hr
 
 61
embryo 22-24hr
 
 56
larva L1
 
 88
larva L2
 
 27
larva L3 12hr old
 
 19
larva L3 puffstage 1-2
 
 8
larva L3 puffstage 3-6
 
 23
larva L3 puffstage 7-9
 
 20
white prepupae new
 
 43
white prepupae 12hr
 
 67
white prepupae 24hr
 
 34
pupae 2d postWPP
 
 1010
pupae 3d postWPP
 
 3004
pupae 4d postWPP
 
 4041
adult male 01day
 
 4391
adult male 05day
 
 5037
adult male 30day
 
 6633
adult female 01day
 
 2587
adult female 05day
 
 952
adult female 30day
 
 1084
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
Linear, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 6
embryo 02-04hr
 
 42
embryo 04-06hr
 
 70
embryo 06-08hr
 
 225
embryo 08-10hr
 
 201
embryo 10-12hr
 
 160
embryo 12-14hr
 
 104
embryo 14-16hr
 
 92
embryo 16-18hr
 
 61
embryo 18-20hr
 
 54
embryo 20-22hr
 
 61
embryo 22-24hr
 
 56
larva L1
 
 88
larva L2
 
 27
larva L3 12hr old
 
 19
larva L3 puffstage 1-2
 
 8
larva L3 puffstage 3-6
 
 23
larva L3 puffstage 7-9
 
 20
white prepupae new
 
 43
white prepupae 12hr
 
 67
white prepupae 24hr
 
 34
pupae 2d postWPP
 
 1010
pupae 3d postWPP
 
 3004
pupae 4d postWPP
 
 4041
adult male 01day
 
 4391
adult male 05day
 
 5037
adult male 30day
 
 6633
adult female 01day
 
 2587
adult female 05day
 
 952
adult female 30day
 
 1084
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
log, scaled to maximum FBgn0001263 expression level
Developmental Stage   Expression Level
embryo 00-02hr
 
 6
embryo 02-04hr
 
 42
embryo 04-06hr
 
 70
embryo 06-08hr
 
 225
embryo 08-10hr
 
 201
embryo 10-12hr
 
 160
embryo 12-14hr
 
 104
embryo 14-16hr
 
 92
embryo 16-18hr
 
 61
embryo 18-20hr
 
 54
embryo 20-22hr
 
 61
embryo 22-24hr
 
 56
larva L1
 
 88
larva L2
 
 27
larva L3 12hr old
 
 19
larva L3 puffstage 1-2
 
 8
larva L3 puffstage 3-6
 
 23
larva L3 puffstage 7-9
 
 20
white prepupae new
 
 43
white prepupae 12hr
 
 67
white prepupae 24hr
 
 34
pupae 2d postWPP
 
 1010
pupae 3d postWPP
 
 3004
pupae 4d postWPP
 
 4041
adult male 01day
 
 4391
adult male 05day
 
 5037
adult male 30day
 
 6633
adult female 01day
 
 2587
adult female 05day
 
 952
adult female 30day
 
 1084
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Very low expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 6
embryo 02-04hr
 
 42
embryo 04-06hr
 
 70
embryo 06-08hr
 (225)
embryo 08-10hr
 (201)
embryo 10-12hr
 (160)
embryo 12-14hr
 104
embryo 14-16hr
 
 92
embryo 16-18hr
 
 61
embryo 18-20hr
 
 54
embryo 20-22hr
 
 61
embryo 22-24hr
 
 56
larva L1
 
 88
larva L2
 
 27
larva L3 12hr old
 
 19
larva L3 puffstage 1-2
 
 8
larva L3 puffstage 3-6
 
 23
larva L3 puffstage 7-9
 
 20
white prepupae new
 
 43
white prepupae 12hr
 
 67
white prepupae 24hr
 
 34
pupae 2d postWPP
 (1010)
pupae 3d postWPP
 (3004)
pupae 4d postWPP
 (4041)
adult male 01day
 (4391)
adult male 05day
 (5037)
adult male 30day
 (6633)
adult female 01day
 (2587)
adult female 05day
 (952)
adult female 30day
 (1084)
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
log, scaled to Moderate expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 6
embryo 02-04hr
 
 42
embryo 04-06hr
 
 70
embryo 06-08hr
 
 225
embryo 08-10hr
 
 201
embryo 10-12hr
 
 160
embryo 12-14hr
 
 104
embryo 14-16hr
 
 92
embryo 16-18hr
 
 61
embryo 18-20hr
 
 54
embryo 20-22hr
 
 61
embryo 22-24hr
 
 56
larva L1
 
 88
larva L2
 
 27
larva L3 12hr old
 
 19
larva L3 puffstage 1-2
 
 8
larva L3 puffstage 3-6
 
 23
larva L3 puffstage 7-9
 
 20
white prepupae new
 
 43
white prepupae 12hr
 
 67
white prepupae 24hr
 
 34
pupae 2d postWPP
 
 1010
pupae 3d postWPP
 (3004)
pupae 4d postWPP
 (4041)
adult male 01day
 (4391)
adult male 05day
 (5037)
adult male 30day
 (6633)
adult female 01day
 (2587)
adult female 05day
 
 952
adult female 30day
 
 1084
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
log, scaled to High expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 6
embryo 02-04hr
 
 42
embryo 04-06hr
 
 70
embryo 06-08hr
 
 225
embryo 08-10hr
 
 201
embryo 10-12hr
 
 160
embryo 12-14hr
 
 104
embryo 14-16hr
 
 92
embryo 16-18hr
 
 61
embryo 18-20hr
 
 54
embryo 20-22hr
 
 61
embryo 22-24hr
 
 56
larva L1
 
 88
larva L2
 
 27
larva L3 12hr old
 
 19
larva L3 puffstage 1-2
 
 8
larva L3 puffstage 3-6
 
 23
larva L3 puffstage 7-9
 
 20
white prepupae new
 
 43
white prepupae 12hr
 
 67
white prepupae 24hr
 
 34
pupae 2d postWPP
 
 1010
pupae 3d postWPP
 
 3004
pupae 4d postWPP
 
 4041
adult male 01day
 
 4391
adult male 05day
 
 5037
adult male 30day
 
 6633
adult female 01day
 
 2587
adult female 05day
 
 952
adult female 30day
 
 1084
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
log, scaled to Extremely high expression
Developmental Stage   Expression Level
embryo 00-02hr
 
 6
embryo 02-04hr
 
 42
embryo 04-06hr
 
 70
embryo 06-08hr
 
 225
embryo 08-10hr
 
 201
embryo 10-12hr
 
 160
embryo 12-14hr
 
 104
embryo 14-16hr
 
 92
embryo 16-18hr
 
 61
embryo 18-20hr
 
 54
embryo 20-22hr
 
 61
embryo 22-24hr
 
 56
larva L1
 
 88
larva L2
 
 27
larva L3 12hr old
 
 19
larva L3 puffstage 1-2
 
 8
larva L3 puffstage 3-6
 
 23
larva L3 puffstage 7-9
 
 20
white prepupae new
 
 43
white prepupae 12hr
 
 67
white prepupae 24hr
 
 34
pupae 2d postWPP
 
 1010
pupae 3d postWPP
 
 3004
pupae 4d postWPP
 
 4041
adult male 01day
 
 4391
adult male 05day
 
 5037
adult male 30day
 
 6633
adult female 01day
 
 2587
adult female 05day
 
 952
adult female 30day
 
 1084
Expression Level Scale
 None 
 Extremely low 
 Very low 
 Low 
 Moderate 
 Moderately high 
 High 
 Very high 
 Extremely high 
Heatmap
Developmental Stage   Expression Level
embryo 00-02hr
 
 
embryo 02-04hr
 
 
embryo 04-06hr
 
 
embryo 06-08hr
 
 
embryo 08-10hr
 
 
embryo 10-12hr
 
 
embryo 12-14hr
 
 
embryo 14-16hr
 
 
embryo 16-18hr
 
 
embryo 18-20hr
 
 
embryo 20-22hr
 
 
embryo 22-24hr
 
 
larva L1
 
 
larva L2
 
 
larva L3 12hr old
 
 
larva L3 puffstage 1-2
 
 
larva L3 puffstage 3-6
 
 
larva L3 puffstage 7-9
 
 
white prepupae new
 
 
white prepupae 12hr
 
 
white prepupae 24hr
 
 
pupae 2d postWPP
 
 
pupae 3d postWPP
 
 
pupae 4d postWPP
 
 
adult male 01day
 
 
adult male 05day
 
 
adult male 30day
 
 
adult female 01day
 
 
adult female 05day
 
 
adult female 30day
 
 

FlyAtlas Anatomical Expression Data for FBgn0001263


   Styles
Linear
Logarithmic
Heatmap
Back-to-back
   Scales
max expr for FBgn0001263
Moderate expression bin max
High level expression bin max
Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye.
[download data (TSV)]

Guide to FlyAtlas expression level colors
 
No expression (0 - 9.999)
 
Low expression (10 - 99.999)
 
Moderate expression (100 - 499.999)
 
High level expression (500 - 999.999)
 
Very high expression (1000 - 25000)

Linear, scaled to maximum FBgn0001263 expression level
Tissue   Expression Level
Larval Central Nervous System
 
 1.5
Larval Midgut
 
 2.9
Larval Hindgut
 
 0.9
Larval Malpighian Tubules
 
 0.5
Larval Fat Body
 
 1
Larval Salivary Gland
 
 0.8
Larval Trachea no informative data
Larval Carcass
 
 0.85
Adult Head
 
 1090.8
Adult Eye
 
 3889.3
Adult Brain
 
 29.3
Adult Thoracic-Abdominal Ganglion
 
 0.9
Adult Crop
 
 1
Adult Midgut
 
 0.8
Adult Hindgut
 
 0.9
Adult Malpighian Tubules
 
 1.3
Adult Fat Body
 
 0.8
Adult Salivary Gland
 
 2.2
Adult Heart
 
 1.3
Adult VirginFemale Spermatheca
 
 0.5
Adult InseminatedFemale Spermatheca
 
 0.7
Adult Ovary
 
 0.7
Adult Testis
 
 1
Adult Male Accessory Gland
 
 1
Adult Carcass
 
 1.1
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Linear, scaled to Moderate expression
Tissue   Expression Level
Larval Central Nervous System
 
 1.5
Larval Midgut
 
 2.9
Larval Hindgut
 
 0.9
Larval Malpighian Tubules
 
 0.5
Larval Fat Body
 
 1
Larval Salivary Gland
 
 0.8
Larval Trachea no informative data
Larval Carcass
 
 0.85
Adult Head
 (1090.8)
Adult Eye
 (3889.3)
Adult Brain
 
 29.3
Adult Thoracic-Abdominal Ganglion
 
 0.9
Adult Crop
 
 1
Adult Midgut
 
 0.8
Adult Hindgut
 
 0.9
Adult Malpighian Tubules
 
 1.3
Adult Fat Body
 
 0.8
Adult Salivary Gland
 
 2.2
Adult Heart
 
 1.3
Adult VirginFemale Spermatheca
 
 0.5
Adult InseminatedFemale Spermatheca
 
 0.7
Adult Ovary
 
 0.7
Adult Testis
 
 1
Adult Male Accessory Gland
 
 1
Adult Carcass
 
 1.1
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
Linear, scaled to High level expression
Tissue   Expression Level
Larval Central Nervous System
 
 1.5
Larval Midgut
 
 2.9
Larval Hindgut
 
 0.9
Larval Malpighian Tubules
 
 0.5
Larval Fat Body
 
 1
Larval Salivary Gland
 
 0.8
Larval Trachea no informative data
Larval Carcass
 
 0.85
Adult Head
 (1090.8)
Adult Eye
 (3889.3)
Adult Brain
 
 29.3
Adult Thoracic-Abdominal Ganglion
 
 0.9
Adult Crop
 
 1
Adult Midgut
 
 0.8
Adult Hindgut
 
 0.9
Adult Malpighian Tubules
 
 1.3
Adult Fat Body
 
 0.8
Adult Salivary Gland
 
 2.2
Adult Heart
 
 1.3
Adult VirginFemale Spermatheca
 
 0.5
Adult InseminatedFemale Spermatheca
 
 0.7
Adult Ovary
 
 0.7
Adult Testis
 
 1
Adult Male Accessory Gland
 
 1
Adult Carcass
 
 1.1
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Linear, scaled to Very high expression
Tissue   Expression Level
Larval Central Nervous System
 
 1.5
Larval Midgut
 
 2.9
Larval Hindgut
 
 0.9
Larval Malpighian Tubules
 
 0.5
Larval Fat Body
 
 1
Larval Salivary Gland
 
 0.8
Larval Trachea no informative data
Larval Carcass
 
 0.85
Adult Head
 
 1090.8
Adult Eye
 
 3889.3
Adult Brain
 
 29.3
Adult Thoracic-Abdominal Ganglion
 
 0.9
Adult Crop
 
 1
Adult Midgut
 
 0.8
Adult Hindgut
 
 0.9
Adult Malpighian Tubules
 
 1.3
Adult Fat Body
 
 0.8
Adult Salivary Gland
 
 2.2
Adult Heart
 
 1.3
Adult VirginFemale Spermatheca
 
 0.5
Adult InseminatedFemale Spermatheca
 
 0.7
Adult Ovary
 
 0.7
Adult Testis
 
 1
Adult Male Accessory Gland
 
 1
Adult Carcass
 
 1.1
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to maximum FBgn0001263 expression level
Tissue   Expression Level
Larval Central Nervous System
 
 1.5
Larval Midgut
 
 2.9
Larval Hindgut
 
 0.9
Larval Malpighian Tubules
 
 0.5
Larval Fat Body
 
 1
Larval Salivary Gland
 
 0.8
Larval Trachea no informative data
Larval Carcass
 
 0.85
Adult Head
 
 1090.8
Adult Eye
 
 3889.3
Adult Brain
 
 29.3
Adult Thoracic-Abdominal Ganglion
 
 0.9
Adult Crop
 
 1
Adult Midgut
 
 0.8
Adult Hindgut
 
 0.9
Adult Malpighian Tubules
 
 1.3
Adult Fat Body
 
 0.8
Adult Salivary Gland
 
 2.2
Adult Heart
 
 1.3
Adult VirginFemale Spermatheca
 
 0.5
Adult InseminatedFemale Spermatheca
 
 0.7
Adult Ovary
 
 0.7
Adult Testis
 
 1
Adult Male Accessory Gland
 
 1
Adult Carcass
 
 1.1
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to Moderate expression
Tissue   Expression Level
Larval Central Nervous System
 
 1.5
Larval Midgut
 
 2.9
Larval Hindgut
 
 0.9
Larval Malpighian Tubules
 
 0.5
Larval Fat Body
 
 1
Larval Salivary Gland
 
 0.8
Larval Trachea no informative data
Larval Carcass
 
 0.85
Adult Head
 (1090.8)
Adult Eye
 (3889.3)
Adult Brain
 
 29.3
Adult Thoracic-Abdominal Ganglion
 
 0.9
Adult Crop
 
 1
Adult Midgut
 
 0.8
Adult Hindgut
 
 0.9
Adult Malpighian Tubules
 
 1.3
Adult Fat Body
 
 0.8
Adult Salivary Gland
 
 2.2
Adult Heart
 
 1.3
Adult VirginFemale Spermatheca
 
 0.5
Adult InseminatedFemale Spermatheca
 
 0.7
Adult Ovary
 
 0.7
Adult Testis
 
 1
Adult Male Accessory Gland
 
 1
Adult Carcass
 
 1.1
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
log, scaled to High level expression
Tissue   Expression Level
Larval Central Nervous System
 
 1.5
Larval Midgut
 
 2.9
Larval Hindgut
 
 0.9
Larval Malpighian Tubules
 
 0.5
Larval Fat Body
 
 1
Larval Salivary Gland
 
 0.8
Larval Trachea no informative data
Larval Carcass
 
 0.85
Adult Head
 1090.8
Adult Eye
 (3889.3)
Adult Brain
 
 29.3
Adult Thoracic-Abdominal Ganglion
 
 0.9
Adult Crop
 
 1
Adult Midgut
 
 0.8
Adult Hindgut
 
 0.9
Adult Malpighian Tubules
 
 1.3
Adult Fat Body
 
 0.8
Adult Salivary Gland
 
 2.2
Adult Heart
 
 1.3
Adult VirginFemale Spermatheca
 
 0.5
Adult InseminatedFemale Spermatheca
 
 0.7
Adult Ovary
 
 0.7
Adult Testis
 
 1
Adult Male Accessory Gland
 
 1
Adult Carcass
 
 1.1
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
log, scaled to Very high expression
Tissue   Expression Level
Larval Central Nervous System
 
 1.5
Larval Midgut
 
 2.9
Larval Hindgut
 
 0.9
Larval Malpighian Tubules
 
 0.5
Larval Fat Body
 
 1
Larval Salivary Gland
 
 0.8
Larval Trachea no informative data
Larval Carcass
 
 0.85
Adult Head
 
 1090.8
Adult Eye
 
 3889.3
Adult Brain
 
 29.3
Adult Thoracic-Abdominal Ganglion
 
 0.9
Adult Crop
 
 1
Adult Midgut
 
 0.8
Adult Hindgut
 
 0.9
Adult Malpighian Tubules
 
 1.3
Adult Fat Body
 
 0.8
Adult Salivary Gland
 
 2.2
Adult Heart
 
 1.3
Adult VirginFemale Spermatheca
 
 0.5
Adult InseminatedFemale Spermatheca
 
 0.7
Adult Ovary
 
 0.7
Adult Testis
 
 1
Adult Male Accessory Gland
 
 1
Adult Carcass
 
 1.1
Expression Level Scale
 None 
 Low 
 Moderate 
 High 
 Very high 
Heatmap
Tissue   Expression Level
Larval Central Nervous System
 
 
Larval Midgut
 
 
Larval Hindgut
 
 
Larval Malpighian Tubules
 
 
Larval Fat Body
 
 
Larval Salivary Gland
 
 
Larval Trachea no informative data
Larval Carcass
 
 
Adult Head
 
 
Adult Eye
 
 
Adult Brain
 
 
Adult Thoracic-Abdominal Ganglion
 
 
Adult Crop
 
 
Adult Midgut
 
 
Adult Hindgut
 
 
Adult Malpighian Tubules
 
 
Adult Fat Body
 
 
Adult Salivary Gland
 
 
Adult Heart
 
 
Adult VirginFemale Spermatheca
 
 
Adult InseminatedFemale Spermatheca
 
 
Adult Ovary
 
 
Adult Testis
 
 
Adult Male Accessory Gland
 
 
Adult Carcass
 
 

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level Tissue Adult Expression Level
 
NA 
Head
 
 1090.8
 
NA 
Eye
 
 3889.3
 
NA 
Brain
 
 29.3
 
1.5 
Central Nervous System
 
 NA
 
NA 
Thoracic-Abdominal Ganglion
 
 0.9
 
NA 
Crop
 
 1
 
2.9 
Midgut
 
 0.8
 
0.9 
Hindgut
 
 0.9
 
0.5 
Malpighian Tubules
 
 1.3
 
Fat Body
 
 0.8
 
0.8 
Salivary Gland
 
 2.2
 
NA 
Heart
 
 1.3
 
no informative data 
Trachea
 
 NA
 
NA 
VirginFemale Spermatheca
 
 0.5
 
NA 
InseminatedFemale Spermatheca
 
 0.7
 
NA 
Ovary
 
 0.7
 
NA 
Testis
 
 1
 
NA 
Male Accessory Gland
 
 1
 
0.85 
Carcass
 
 1.1

modENCODE Temporal Expression Data (Graveley et al., 2011)
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
hide Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
hide External Data & Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyExpress - Embryonic expression images (BDGP data)
hide Alleles & Phenotypes
hide Summary of Allele Phenotypes
Lethality
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
hide Classical Alleles ( 7 )
For All Classical Alleles Show

Allele of inaDClassMutagenStocksKnown lesion
inaDP2150 Yes
inaDsu1000 Yes
inaDsu10 Yes
inaDT10 Yes
inaDT20 Yes
inaDttd100 --
inaDunspecified
0 --
hide Alleles Carried on Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show

Allele of inaDClassMutagenStocksKnown lesion
inaDGD109891 Yes
inaDC645S.ninaE0 Yes
inaDdsRNA.cRa0 Yes
inaDGMR.PT0 Yes
inaDGMR.T:Avic\GFP0 Yes
inaDhs.PS0 Yes
inaDhs.PT0 Yes
inaDninaE.PM0 Yes
inaDPDZ1.GMR0 Yes
inaDPDZ2.GMR0 Yes
inaDPDZ3.GMR0 Yes
inaDPDZ4.GMR0 Yes
inaDPDZ5.GMR0 Yes
hide Aneuploid Aberrations
Disrupted in
Not disrupted in
hide Transgenic Constructs & Insertions
Transgenic Constructs
Type of construct
Name
Expression data
heat-shock construct
UAS construct
Insertions
Type of insertions
Name
Expression data
hide Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
hide Terms Based on Experimental Evidence ( 9 terms )
Molecular Function
CV term
References
inferred from physical interaction with ninaC
inferred from physical interaction with UniProtKB:P13677
(assigned by UniProtKB)
inferred from direct assay AND inferred from mutant phenotype
inferred from mutant phenotype
Biological Process
CV term
References
inferred from mutant phenotype
inferred from physical interaction with trp
Cellular Component
CV term
References
inferred from physical interaction with inaC
inferred from physical interaction with ninaE AND inferred from physical interaction with trp
inferred from physical interaction with norpA
inferred from physical interaction with trp
inferred from direct assay
hide Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term
References
traceable author statement
traceable author statement
Biological Process
CV term
References
non-traceable author statement
traceable author statement
Cellular Component
CV term
References
hide Sequence Ontology: Class of Gene
hide Interactions & Pathways
hide Summary of Physical Interactions
Protein-protein
Interacting group
Assay
References
hide Summary of Genetic Interactions
Interacts with
Please look at the allele data for full details of the genetic interactions
inaD allele
Gene
References
hide External Data
Linkouts
BioGRID - A database of protein and genetic interactions
DroID - A comprehensive database of gene and protein interactions.
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
hide Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs
Linkouts
InParanoid A subset of ortholog calls from InParanoid.
OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.
hide Stocks & Reagents
hide Stocks Listed in FlyBase ( 1 )
VDRC
hide Genomic Clones ( 1 )
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
hide cDNA Clones ( 64 )
Please Note
This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
hide RNAi & Array Information
Linkouts
DRSC - Results from RNAi screens.
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
hide Antibody Information
hide Other Information
hide Discoverer
hide Etymology
hide Identification
hide Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
hide Other Comments
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
The trp-inaD protein-protein interaction is required for maintaining transduction complexes in the rhabdomeres.
The fact that the ability of non-inaD bound trp to contribute to photoreceptor responses depends on the presence of trpl suggests that there may be interactions between trpl and the non-inaD-bound trp protein.
inaD protein is required for retention rather than targetting of trp protein to rhabdomeres.
The second PDZ domain of inaD protein interacts with the last three residues in the carboxyl-terminal tail of inaC protein.
inaD functions as a master scaffold for subcellular compartmentalization of the phototransduction machinery.
inaD protein binds directly to norpA protein via two terminally positioned PDZ1 and PDZ5 domains. PDZ1 binds to the C-terminus of norpA, while PDZ5 binds to an internal region overlapping with the G-box homology region.
A PDZ domain is required in vivo for anchoring an ion channel to its normal subcellular site: inaD is required for spatially localising trp to a large signalling complex.
A novel tripeptide motif in the C terminus of norpA associates with inaD. Expression of transgenic norpA that displays no interaction with inaD reveals abnormal ERG with slow kinetics suggesting the association between inaD and norpA is important in the regulation of activation and deactivation of visual transduction.
The inaD protein is composed of five distinct PDZ domains and acts as an organising scaffold for photoreceptor signalling complexes in vivo.
Antibodies to the inaD protein co-precipitate trp gene product. The interaction has been mapped to the 19 amino acid C-terminus of trp and the PDZ domain of inaD. inaD functions as a regulatory subunit of the trp Ca2+ channel.
Mutations in inaD suggest that inaD is involved in the negative feedback regulation of the light-activated signaling cascade in photoreceptors.
hide External Crossreferences & Linkouts
Sequence Crossreferences
RefSeq (Transcripts)
RefSeq (Proteins)
Entrez Gene - A searchable database of RefSeq genes.
Other Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
PDZ/DHR/GLGF (IPR001478)
PDB - Protein Data Bank. An information portal to biological macromolecular structures
Linkouts
BioGRID - A database of protein and genetic interactions
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results from RNAi screens.
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
InParanoid A subset of ortholog calls from InParanoid.
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.
modMine - Data generated by the modENCODE project.
OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.
hide Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym
Name Synonym
inactivation, no after-depolarization
inactivation no afterpotential D
inactivation-no after potential D
Inactivation no afterpotential D
inactivation-no-afterpotential-D
inactivation-no-afterpotential D
Secondary FlyBase IDs
hide References ( 139 )
Generate a list of
List References by type
hide Recent research papers ( 7 )
Cao et al., 2011, EMBO J. 30(18): 3701--3713
A Drosophila metallophosphoesterase mediates deglycosylation of rhodopsin. [FBrf0215269]
Liu et al., 2011, Cell 145(7): 1088--1101
The INAD Scaffold Is a Dynamic, Redox-Regulated Modulator of Signaling in the Drosophila Eye. [FBrf0214003]
Mecklenburg et al., 2010, J. Neurosci. 30(4): 1238--1249
Retinophilin is a light-regulated phosphoprotein required to suppress photoreceptor dark noise in Drosophila. [FBrf0209881]
Sanxaridis and Tsunoda, 2010, Fly 4(2): 95--103
A forward genetic screen in Drosophila melanogaster to identify mutations affecting INAD localization in photoreceptor cells. [FBrf0211062]
Venkatachalam et al., 2010, J. Neurosci. 30(34): 11337--11345
Dependence on a Retinophilin/Myosin Complex for Stability of PKC and INAD and Termination of Phototransduction. [FBrf0211598]
Wang et al., 2010, Curr. Biol. 20(2): 93--102
Requirement for an Enzymatic Visual Cycle in Drosophila. [FBrf0209891]
Yao and Carlson, 2010, J. Neurosci. 30(13): 4562--4572
Role of G-proteins in odor-sensing and CO2-sensing neurons in Drosophila. [FBrf0210441]
hide Recent reviews (0)
All reviews listed in FlyBase were published before 2010