Gene model reviewed during 5.49
There is only one protein coding transcript and one polypeptide associated with this gene
Component of the Mediator complex (By similarity). Self-associates. Interacts with dsx.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\ix using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\ix in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
ix is required for complete differentiation of female but not male specific adult cuticular structures.
Levels of haemolymph vitellogenin of ix flies tentatively suggest ix gene function is neither required for vitellogenin synthesis nor for maintaining proper level of dosage compensation of yolk protein genes. In ix mutant males the yolk protein gene expression is further repressed which suggests the gene is inactive at least in the fat body cells of the males.
At the morphological level, a loss of ix+ function results in the simultaneous realization of both male and female developmental pathways in diplo-X individuals. The ix product is required to function with the female-specific product of dsx to implement appropriate female sexual differentiation in diplo-X individuals. ix does not have a role in sexual behaviour in haplo-X individuals. Clonal analysis suggests that ix functions in a cell-autonomous manner in the abdomen and that it is required in the abdominal histoblasts after the resumption of cell division at pupariation for the normal sexual development of the abdominal tergites.
ix plays no role in the development of sexually dimorphic skeletal muscles.