General Information Symbol Dmel\ janASpecies D. melanogaster Name janus A Annotation symbol CG7933 Feature type protein_coding_gene FlyBase ID FBgn0001280 Gene Model Status Current Stock availability 5 publicly
available Also Known As janus, jan, Y Genomic Location Chromosome (arm) 3R Recombination map Cytogenetic map 99D3-99D3 Sequence location 3R:25,864,344..25,865,255 [-]
Genomic Maps
Summary Information Automatically generated summary
See sections below for more information The gene
janus A is referred to in FlyBase by the symbol
Dmel\janA (CG7933, FBgn0001280). It is a protein_coding_gene from
Drosophila melanogaster . Its
molecular function is unknown. There is experimental evidence that it is involved in the
biological process : sex differentiation.
10 alleles are reported . No phenotypic data is available. It has
3 annotated transcripts and
3 annotated polypeptides .
Protein features are: Janus/Ocnus. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, larval trachea, adult ovary, adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, adult spermathecae, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1623271_a_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of janA. Gene sequence location is
3R:25864344..25865255 .
User Contributed Data
Phenotypic Description from the Red Book (Lindsley
& Zimm 1992) Gene/Allele symbols may differ
from current usage jan: janus
Two partially overlapping genes, janA and janB,
regulate the expression of somatic sex differentiation. janA
is expressed in a complex way in both males and females; janB
is only expressed in males (Yanicostas et al., 1989).
Recent Updates
Description
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It currently only tracks new links between this FlyBase report and other
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FB2013_03
FB2013_02
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Detailed Mapping Data
FlyBase Computed Cytological Location
Experimentally Determined Cytological Location
Experimentally Determined Recombination Data
Location Left of (cM) Right of (cM) Notes Gene Model & Products Comments on Gene
Model Gene model reviewed during 5.47
Evidence indicates that 3' UTR overlaps 5' UTR of downstream gene
Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data Annotated Transcripts Additional Transcript Data
& Comments Reported size (kB) Comments External Data Crossreferences
Polypeptide Data Annotated
Polypeptides Additional Polypeptide
Data & Comments Reported size (kDa) 135, 119 (aa); 12 (kD predicted)
Comments One of a couple of products generated by alternative splicing.
External Data Linkouts Crossreferences
domains - A database of protein families, domains, and functional sites
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank UniProtKB/Swiss-Prot UniProtKB/TrEMBL Mapped Features Mapped Features have been reorganized, please
see this article for details. Additional mapped features and mutations can
be found on GBrowse or related reports. regulatory region
evidence=experimental
comment=
janA cis regulatory sequences; see
@lacZjanA.-56 RA @ for expression pattern
regulatory region
comment=DNA replication-related element TATCGATA evidence=predicted
regulatory region
evidence=Reporter construct (in vivo)
External Data Linkouts Crossreferences Expression Data Transcript ExpressionComment: maternally deposited
Comment: reported as dorsal/lateral sensory complexes
Additional Descriptive Data
Marker for Subcellular Localization CV Term Polypeptide Expression
Additional Descriptive Data
Marker for Subcellular Localization (GO Cellular Component) Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference
FlyAtlas Anatomy Microarray
Linear, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
615.5
Larval Midgut
107.6
Larval Hindgut
205.1
Larval Malpighian Tubules
285.3
Larval Fat Body
364.6
Larval Salivary Gland
420.9
Larval Trachea
565.625
Larval Carcass
346.75
Adult Head
251.1
Adult Eye
287.575
Adult Brain
209.1
Adult Thoracic-Abdominal Ganglion
192.9
Adult Crop
376.4
Adult Midgut
172.8
Adult Hindgut
201.3
Adult Malpighian Tubules
224.7
Adult Fat Body
254.9
Adult Salivary Gland
294.1
Adult Heart
321.8
Adult VirginFemale Spermatheca
333.1
Adult InseminatedFemale Spermatheca
294.9
Adult Ovary
545.6
Adult Testis
1042.8
Adult Male Accessory Gland
267.4
Adult Carcass
241.8
Expression Level Scale
None
Low
Moderate
High
Very high
Linear, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
(615.5)
Larval Midgut
107.6
Larval Hindgut
205.1
Larval Malpighian Tubules
285.3
Larval Fat Body
364.6
Larval Salivary Gland
420.9
Larval Trachea
(565.625)
Larval Carcass
346.75
Adult Head
251.1
Adult Eye
287.575
Adult Brain
209.1
Adult Thoracic-Abdominal Ganglion
192.9
Adult Crop
376.4
Adult Midgut
172.8
Adult Hindgut
201.3
Adult Malpighian Tubules
224.7
Adult Fat Body
254.9
Adult Salivary Gland
294.1
Adult Heart
321.8
Adult VirginFemale Spermatheca
333.1
Adult InseminatedFemale Spermatheca
294.9
Adult Ovary
(545.6)
Adult Testis
(1042.8)
Adult Male Accessory Gland
267.4
Adult Carcass
241.8
Expression Level Scale
None
Low
Moderate
High
Linear, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
615.5
Larval Midgut
107.6
Larval Hindgut
205.1
Larval Malpighian Tubules
285.3
Larval Fat Body
364.6
Larval Salivary Gland
420.9
Larval Trachea
565.625
Larval Carcass
346.75
Adult Head
251.1
Adult Eye
287.575
Adult Brain
209.1
Adult Thoracic-Abdominal Ganglion
192.9
Adult Crop
376.4
Adult Midgut
172.8
Adult Hindgut
201.3
Adult Malpighian Tubules
224.7
Adult Fat Body
254.9
Adult Salivary Gland
294.1
Adult Heart
321.8
Adult VirginFemale Spermatheca
333.1
Adult InseminatedFemale Spermatheca
294.9
Adult Ovary
545.6
Adult Testis
1042.8
Adult Male Accessory Gland
267.4
Adult Carcass
241.8
Expression Level Scale
None
Low
Moderate
High
Very high
Linear, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
615.5
Larval Midgut
107.6
Larval Hindgut
205.1
Larval Malpighian Tubules
285.3
Larval Fat Body
364.6
Larval Salivary Gland
420.9
Larval Trachea
565.625
Larval Carcass
346.75
Adult Head
251.1
Adult Eye
287.575
Adult Brain
209.1
Adult Thoracic-Abdominal Ganglion
192.9
Adult Crop
376.4
Adult Midgut
172.8
Adult Hindgut
201.3
Adult Malpighian Tubules
224.7
Adult Fat Body
254.9
Adult Salivary Gland
294.1
Adult Heart
321.8
Adult VirginFemale Spermatheca
333.1
Adult InseminatedFemale Spermatheca
294.9
Adult Ovary
545.6
Adult Testis
1042.8
Adult Male Accessory Gland
267.4
Adult Carcass
241.8
Expression Level Scale
Very high
log, scaled to maximum expression level
Tissue
Expression Level
Larval Central Nervous System
615.5
Larval Midgut
107.6
Larval Hindgut
205.1
Larval Malpighian Tubules
285.3
Larval Fat Body
364.6
Larval Salivary Gland
420.9
Larval Trachea
565.625
Larval Carcass
346.75
Adult Head
251.1
Adult Eye
287.575
Adult Brain
209.1
Adult Thoracic-Abdominal Ganglion
192.9
Adult Crop
376.4
Adult Midgut
172.8
Adult Hindgut
201.3
Adult Malpighian Tubules
224.7
Adult Fat Body
254.9
Adult Salivary Gland
294.1
Adult Heart
321.8
Adult VirginFemale Spermatheca
333.1
Adult InseminatedFemale Spermatheca
294.9
Adult Ovary
545.6
Adult Testis
1042.8
Adult Male Accessory Gland
267.4
Adult Carcass
241.8
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to Moderate expression
Tissue
Expression Level
Larval Central Nervous System
615.5
Larval Midgut
107.6
Larval Hindgut
205.1
Larval Malpighian Tubules
285.3
Larval Fat Body
364.6
Larval Salivary Gland
420.9
Larval Trachea
565.625
Larval Carcass
346.75
Adult Head
251.1
Adult Eye
287.575
Adult Brain
209.1
Adult Thoracic-Abdominal Ganglion
192.9
Adult Crop
376.4
Adult Midgut
172.8
Adult Hindgut
201.3
Adult Malpighian Tubules
224.7
Adult Fat Body
254.9
Adult Salivary Gland
294.1
Adult Heart
321.8
Adult VirginFemale Spermatheca
333.1
Adult InseminatedFemale Spermatheca
294.9
Adult Ovary
545.6
Adult Testis
(1042.8)
Adult Male Accessory Gland
267.4
Adult Carcass
241.8
Expression Level Scale
None
Low
Moderate
High
log, scaled to High level expression
Tissue
Expression Level
Larval Central Nervous System
615.5
Larval Midgut
107.6
Larval Hindgut
205.1
Larval Malpighian Tubules
285.3
Larval Fat Body
364.6
Larval Salivary Gland
420.9
Larval Trachea
565.625
Larval Carcass
346.75
Adult Head
251.1
Adult Eye
287.575
Adult Brain
209.1
Adult Thoracic-Abdominal Ganglion
192.9
Adult Crop
376.4
Adult Midgut
172.8
Adult Hindgut
201.3
Adult Malpighian Tubules
224.7
Adult Fat Body
254.9
Adult Salivary Gland
294.1
Adult Heart
321.8
Adult VirginFemale Spermatheca
333.1
Adult InseminatedFemale Spermatheca
294.9
Adult Ovary
545.6
Adult Testis
1042.8
Adult Male Accessory Gland
267.4
Adult Carcass
241.8
Expression Level Scale
None
Low
Moderate
High
Very high
log, scaled to Very high expression
Tissue
Expression Level
Larval Central Nervous System
615.5
Larval Midgut
107.6
Larval Hindgut
205.1
Larval Malpighian Tubules
285.3
Larval Fat Body
364.6
Larval Salivary Gland
420.9
Larval Trachea
565.625
Larval Carcass
346.75
Adult Head
251.1
Adult Eye
287.575
Adult Brain
209.1
Adult Thoracic-Abdominal Ganglion
192.9
Adult Crop
376.4
Adult Midgut
172.8
Adult Hindgut
201.3
Adult Malpighian Tubules
224.7
Adult Fat Body
254.9
Adult Salivary Gland
294.1
Adult Heart
321.8
Adult VirginFemale Spermatheca
333.1
Adult InseminatedFemale Spermatheca
294.9
Adult Ovary
545.6
Adult Testis
1042.8
Adult Male Accessory Gland
267.4
Adult Carcass
241.8
Expression Level Scale
None
Low
Moderate
High
Very high
Heatmap
Tissue
Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass
FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level
Tissue
Adult Expression Level
NA
Head
251.1
NA
Eye
287.575
NA
Brain
209.1
615.5
Central Nervous System
NA
NA
Thoracic-Abdominal Ganglion
192.9
NA
Crop
376.4
107.6
Midgut
172.8
205.1
Hindgut
201.3
285.3
Malpighian Tubules
224.7
364.6
Fat Body
254.9
420.9
Salivary Gland
294.1
NA
Heart
321.8
565.625
Trachea
NA
NA
VirginFemale Spermatheca
333.1
NA
InseminatedFemale Spermatheca
294.9
NA
Ovary
545.6
NA
Testis
1042.8
NA
Male Accessory Gland
267.4
346.75
Carcass
241.8
modENCODE Anatomy RNA-Seq
Linear, scaled to maximum expression level
Tissue
Expression Level
imaginal disc, larvae L3 wandering
202
central nervous system, larvae L3
122
central nervous system, pupae P8
56
head, virgin 1-day female
26
head, virgin 4-day female
30
head, virgin 20-day female
24
head, mated 1-day female
26
head, mated 4-day female
24
head, mated 20-day female
27
head, mated 1-day male
24
head, mated 4-day male
36
head, mated 20-day male
52
salivary gland, larvae L3 wandering
14
salivary gland, white prepupae
14
digestive system, larvae L3 wandering
41
digestive system, 1-day adult
29
digestive system, 4-day adult
38
digestive system, 20-day adult
27
fat body, larvae L3 wandering
21
fat body, white prepupae
51
fat body, pupae P8
54
carcass, larvae L3 wandering
99
carcass, 1-day adult
27
carcass, 4-day adult
31
carcass, 20-day adult
41
ovary, virgin 4-day female
147
ovary, mated 4-day female
137
testis, mated 4-day male
324
accessory gland, mated 4-day male
65
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Moderate expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
(202)
central nervous system, larvae L3
(122)
central nervous system, pupae P8
(56)
head, virgin 1-day female
26
head, virgin 4-day female
(30)
head, virgin 20-day female
24
head, mated 1-day female
26
head, mated 4-day female
24
head, mated 20-day female
(27)
head, mated 1-day male
24
head, mated 4-day male
(36)
head, mated 20-day male
(52)
salivary gland, larvae L3 wandering
14
salivary gland, white prepupae
14
digestive system, larvae L3 wandering
(41)
digestive system, 1-day adult
(29)
digestive system, 4-day adult
(38)
digestive system, 20-day adult
(27)
fat body, larvae L3 wandering
21
fat body, white prepupae
(51)
fat body, pupae P8
(54)
carcass, larvae L3 wandering
(99)
carcass, 1-day adult
(27)
carcass, 4-day adult
(31)
carcass, 20-day adult
(41)
ovary, virgin 4-day female
(147)
ovary, mated 4-day female
(137)
testis, mated 4-day male
(324)
accessory gland, mated 4-day male
(65)
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
(202)
central nervous system, larvae L3
(122)
central nervous system, pupae P8
56
head, virgin 1-day female
26
head, virgin 4-day female
30
head, virgin 20-day female
24
head, mated 1-day female
26
head, mated 4-day female
24
head, mated 20-day female
27
head, mated 1-day male
24
head, mated 4-day male
36
head, mated 20-day male
52
salivary gland, larvae L3 wandering
14
salivary gland, white prepupae
14
digestive system, larvae L3 wandering
41
digestive system, 1-day adult
29
digestive system, 4-day adult
38
digestive system, 20-day adult
27
fat body, larvae L3 wandering
21
fat body, white prepupae
51
fat body, pupae P8
54
carcass, larvae L3 wandering
99
carcass, 1-day adult
27
carcass, 4-day adult
31
carcass, 20-day adult
41
ovary, virgin 4-day female
(147)
ovary, mated 4-day female
(137)
testis, mated 4-day male
(324)
accessory gland, mated 4-day male
65
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
202
central nervous system, larvae L3
122
central nervous system, pupae P8
56
head, virgin 1-day female
26
head, virgin 4-day female
30
head, virgin 20-day female
24
head, mated 1-day female
26
head, mated 4-day female
24
head, mated 20-day female
27
head, mated 1-day male
24
head, mated 4-day male
36
head, mated 20-day male
52
salivary gland, larvae L3 wandering
14
salivary gland, white prepupae
14
digestive system, larvae L3 wandering
41
digestive system, 1-day adult
29
digestive system, 4-day adult
38
digestive system, 20-day adult
27
fat body, larvae L3 wandering
21
fat body, white prepupae
51
fat body, pupae P8
54
carcass, larvae L3 wandering
99
carcass, 1-day adult
27
carcass, 4-day adult
31
carcass, 20-day adult
41
ovary, virgin 4-day female
147
ovary, mated 4-day female
137
testis, mated 4-day male
324
accessory gland, mated 4-day male
65
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Tissue
Expression Level
imaginal disc, larvae L3 wandering
202
central nervous system, larvae L3
122
central nervous system, pupae P8
56
head, virgin 1-day female
26
head, virgin 4-day female
30
head, virgin 20-day female
24
head, mated 1-day female
26
head, mated 4-day female
24
head, mated 20-day female
27
head, mated 1-day male
24
head, mated 4-day male
36
head, mated 20-day male
52
salivary gland, larvae L3 wandering
14
salivary gland, white prepupae
14
digestive system, larvae L3 wandering
41
digestive system, 1-day adult
29
digestive system, 4-day adult
38
digestive system, 20-day adult
27
fat body, larvae L3 wandering
21
fat body, white prepupae
51
fat body, pupae P8
54
carcass, larvae L3 wandering
99
carcass, 1-day adult
27
carcass, 4-day adult
31
carcass, 20-day adult
41
ovary, virgin 4-day female
147
ovary, mated 4-day female
137
testis, mated 4-day male
324
accessory gland, mated 4-day male
65
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Moderate expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
(202)
central nervous system, larvae L3
(122)
central nervous system, pupae P8
(56)
head, virgin 1-day female
26
head, virgin 4-day female
30
head, virgin 20-day female
24
head, mated 1-day female
26
head, mated 4-day female
24
head, mated 20-day female
27
head, mated 1-day male
24
head, mated 4-day male
(36)
head, mated 20-day male
(52)
salivary gland, larvae L3 wandering
14
salivary gland, white prepupae
14
digestive system, larvae L3 wandering
(41)
digestive system, 1-day adult
29
digestive system, 4-day adult
(38)
digestive system, 20-day adult
27
fat body, larvae L3 wandering
21
fat body, white prepupae
(51)
fat body, pupae P8
(54)
carcass, larvae L3 wandering
(99)
carcass, 1-day adult
27
carcass, 4-day adult
31
carcass, 20-day adult
(41)
ovary, virgin 4-day female
(147)
ovary, mated 4-day female
(137)
testis, mated 4-day male
(324)
accessory gland, mated 4-day male
(65)
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
(202)
central nervous system, larvae L3
122
central nervous system, pupae P8
56
head, virgin 1-day female
26
head, virgin 4-day female
30
head, virgin 20-day female
24
head, mated 1-day female
26
head, mated 4-day female
24
head, mated 20-day female
27
head, mated 1-day male
24
head, mated 4-day male
36
head, mated 20-day male
52
salivary gland, larvae L3 wandering
14
salivary gland, white prepupae
14
digestive system, larvae L3 wandering
41
digestive system, 1-day adult
29
digestive system, 4-day adult
38
digestive system, 20-day adult
27
fat body, larvae L3 wandering
21
fat body, white prepupae
51
fat body, pupae P8
54
carcass, larvae L3 wandering
99
carcass, 1-day adult
27
carcass, 4-day adult
31
carcass, 20-day adult
41
ovary, virgin 4-day female
(147)
ovary, mated 4-day female
137
testis, mated 4-day male
(324)
accessory gland, mated 4-day male
65
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Tissue
Expression Level
imaginal disc, larvae L3 wandering
202
central nervous system, larvae L3
122
central nervous system, pupae P8
56
head, virgin 1-day female
26
head, virgin 4-day female
30
head, virgin 20-day female
24
head, mated 1-day female
26
head, mated 4-day female
24
head, mated 20-day female
27
head, mated 1-day male
24
head, mated 4-day male
36
head, mated 20-day male
52
salivary gland, larvae L3 wandering
14
salivary gland, white prepupae
14
digestive system, larvae L3 wandering
41
digestive system, 1-day adult
29
digestive system, 4-day adult
38
digestive system, 20-day adult
27
fat body, larvae L3 wandering
21
fat body, white prepupae
51
fat body, pupae P8
54
carcass, larvae L3 wandering
99
carcass, 1-day adult
27
carcass, 4-day adult
31
carcass, 20-day adult
41
ovary, virgin 4-day female
147
ovary, mated 4-day female
137
testis, mated 4-day male
324
accessory gland, mated 4-day male
65
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Tissue
Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male
modENCODE Development RNA-Seq
Linear, scaled to maximum expression level
Developmental Stage
Expression Level
embryo 00-02hr
90
embryo 02-04hr
155
embryo 04-06hr
202
embryo 06-08hr
124
embryo 08-10hr
83
embryo 10-12hr
58
embryo 12-14hr
51
embryo 14-16hr
30
embryo 16-18hr
26
embryo 18-20hr
14
embryo 20-22hr
20
embryo 22-24hr
23
larva L1
19
larva L2
43
larva L3 12hr old
33
larva L3 puffstage 1-2
41
larva L3 puffstage 3-6
46
larva L3 puffstage 7-9
64
white prepupae new
61
white prepupae 12hr
55
white prepupae 24hr
81
pupae 2d postWPP
70
pupae 3d postWPP
67
pupae 4d postWPP
42
adult male 01day
63
adult male 05day
70
adult male 30day
65
adult female 01day
40
adult female 05day
77
adult female 30day
69
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
(90)
embryo 02-04hr
(155)
embryo 04-06hr
(202)
embryo 06-08hr
(124)
embryo 08-10hr
(83)
embryo 10-12hr
(58)
embryo 12-14hr
(51)
embryo 14-16hr
(30)
embryo 16-18hr
26
embryo 18-20hr
14
embryo 20-22hr
20
embryo 22-24hr
23
larva L1
19
larva L2
(43)
larva L3 12hr old
(33)
larva L3 puffstage 1-2
(41)
larva L3 puffstage 3-6
(46)
larva L3 puffstage 7-9
(64)
white prepupae new
(61)
white prepupae 12hr
(55)
white prepupae 24hr
(81)
pupae 2d postWPP
(70)
pupae 3d postWPP
(67)
pupae 4d postWPP
(42)
adult male 01day
(63)
adult male 05day
(70)
adult male 30day
(65)
adult female 01day
(40)
adult female 05day
(77)
adult female 30day
(69)
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
90
embryo 02-04hr
(155)
embryo 04-06hr
(202)
embryo 06-08hr
(124)
embryo 08-10hr
83
embryo 10-12hr
58
embryo 12-14hr
51
embryo 14-16hr
30
embryo 16-18hr
26
embryo 18-20hr
14
embryo 20-22hr
20
embryo 22-24hr
23
larva L1
19
larva L2
43
larva L3 12hr old
33
larva L3 puffstage 1-2
41
larva L3 puffstage 3-6
46
larva L3 puffstage 7-9
64
white prepupae new
61
white prepupae 12hr
55
white prepupae 24hr
81
pupae 2d postWPP
70
pupae 3d postWPP
67
pupae 4d postWPP
42
adult male 01day
63
adult male 05day
70
adult male 30day
65
adult female 01day
40
adult female 05day
77
adult female 30day
69
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
90
embryo 02-04hr
155
embryo 04-06hr
202
embryo 06-08hr
124
embryo 08-10hr
83
embryo 10-12hr
58
embryo 12-14hr
51
embryo 14-16hr
30
embryo 16-18hr
26
embryo 18-20hr
14
embryo 20-22hr
20
embryo 22-24hr
23
larva L1
19
larva L2
43
larva L3 12hr old
33
larva L3 puffstage 1-2
41
larva L3 puffstage 3-6
46
larva L3 puffstage 7-9
64
white prepupae new
61
white prepupae 12hr
55
white prepupae 24hr
81
pupae 2d postWPP
70
pupae 3d postWPP
67
pupae 4d postWPP
42
adult male 01day
63
adult male 05day
70
adult male 30day
65
adult female 01day
40
adult female 05day
77
adult female 30day
69
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Developmental Stage
Expression Level
embryo 00-02hr
90
embryo 02-04hr
155
embryo 04-06hr
202
embryo 06-08hr
124
embryo 08-10hr
83
embryo 10-12hr
58
embryo 12-14hr
51
embryo 14-16hr
30
embryo 16-18hr
26
embryo 18-20hr
14
embryo 20-22hr
20
embryo 22-24hr
23
larva L1
19
larva L2
43
larva L3 12hr old
33
larva L3 puffstage 1-2
41
larva L3 puffstage 3-6
46
larva L3 puffstage 7-9
64
white prepupae new
61
white prepupae 12hr
55
white prepupae 24hr
81
pupae 2d postWPP
70
pupae 3d postWPP
67
pupae 4d postWPP
42
adult male 01day
63
adult male 05day
70
adult male 30day
65
adult female 01day
40
adult female 05day
77
adult female 30day
69
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Moderate expression
Developmental Stage
Expression Level
embryo 00-02hr
(90)
embryo 02-04hr
(155)
embryo 04-06hr
(202)
embryo 06-08hr
(124)
embryo 08-10hr
(83)
embryo 10-12hr
(58)
embryo 12-14hr
(51)
embryo 14-16hr
30
embryo 16-18hr
26
embryo 18-20hr
14
embryo 20-22hr
20
embryo 22-24hr
23
larva L1
19
larva L2
(43)
larva L3 12hr old
(33)
larva L3 puffstage 1-2
(41)
larva L3 puffstage 3-6
(46)
larva L3 puffstage 7-9
(64)
white prepupae new
(61)
white prepupae 12hr
(55)
white prepupae 24hr
(81)
pupae 2d postWPP
(70)
pupae 3d postWPP
(67)
pupae 4d postWPP
(42)
adult male 01day
(63)
adult male 05day
(70)
adult male 30day
(65)
adult female 01day
(40)
adult female 05day
(77)
adult female 30day
(69)
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Developmental Stage
Expression Level
embryo 00-02hr
90
embryo 02-04hr
(155)
embryo 04-06hr
(202)
embryo 06-08hr
124
embryo 08-10hr
83
embryo 10-12hr
58
embryo 12-14hr
51
embryo 14-16hr
30
embryo 16-18hr
26
embryo 18-20hr
14
embryo 20-22hr
20
embryo 22-24hr
23
larva L1
19
larva L2
43
larva L3 12hr old
33
larva L3 puffstage 1-2
41
larva L3 puffstage 3-6
46
larva L3 puffstage 7-9
64
white prepupae new
61
white prepupae 12hr
55
white prepupae 24hr
81
pupae 2d postWPP
70
pupae 3d postWPP
67
pupae 4d postWPP
42
adult male 01day
63
adult male 05day
70
adult male 30day
65
adult female 01day
40
adult female 05day
77
adult female 30day
69
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Developmental Stage
Expression Level
embryo 00-02hr
90
embryo 02-04hr
155
embryo 04-06hr
202
embryo 06-08hr
124
embryo 08-10hr
83
embryo 10-12hr
58
embryo 12-14hr
51
embryo 14-16hr
30
embryo 16-18hr
26
embryo 18-20hr
14
embryo 20-22hr
20
embryo 22-24hr
23
larva L1
19
larva L2
43
larva L3 12hr old
33
larva L3 puffstage 1-2
41
larva L3 puffstage 3-6
46
larva L3 puffstage 7-9
64
white prepupae new
61
white prepupae 12hr
55
white prepupae 24hr
81
pupae 2d postWPP
70
pupae 3d postWPP
67
pupae 4d postWPP
42
adult male 01day
63
adult male 05day
70
adult male 30day
65
adult female 01day
40
adult female 05day
77
adult female 30day
69
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Developmental Stage
Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day
modENCODE Cell Lines RNA-Seq
Linear, scaled to maximum expression level
Cell Line
Expression Level
Schneider line 2 S2R+
197
Schneider line 2 Sg4
192
embryonic 1182-4H
100
embryonic GM2
62
embryonic Kc167
172
embryonic S1
126
embryonic S3
226
leg disc CME L1
197
wing disc CME-W2
361
wing disc ML-DmD8
202
wing disc ML-DmD9
131
wing disc ML-DmD16-c3
147
wing disc ML-DmD21
220
wing disc ML-DmD32
156
haltere disc ML-DmD17-c3
155
eye-antennal disc ML-DmD11
218
antennal disc ML-DmD20-c5
277
mixed discs ML-DmD4-c1
178
CNS ML-DmBG1-c1
266
CNS ML-DmBG2-c2
164
tumorous blood cells mbn2
132
ovary fGS/OSS
52
ovary OSC
110
ovary OSS
54
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Moderate expression
Cell Line
Expression Level
Schneider line 2 S2R+
(197)
Schneider line 2 Sg4
(192)
embryonic 1182-4H
(100)
embryonic GM2
(62)
embryonic Kc167
(172)
embryonic S1
(126)
embryonic S3
(226)
leg disc CME L1
(197)
wing disc CME-W2
(361)
wing disc ML-DmD8
(202)
wing disc ML-DmD9
(131)
wing disc ML-DmD16-c3
(147)
wing disc ML-DmD21
(220)
wing disc ML-DmD32
(156)
haltere disc ML-DmD17-c3
(155)
eye-antennal disc ML-DmD11
(218)
antennal disc ML-DmD20-c5
(277)
mixed discs ML-DmD4-c1
(178)
CNS ML-DmBG1-c1
(266)
CNS ML-DmBG2-c2
(164)
tumorous blood cells mbn2
(132)
ovary fGS/OSS
(52)
ovary OSC
(110)
ovary OSS
(54)
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Cell Line
Expression Level
Schneider line 2 S2R+
(197)
Schneider line 2 Sg4
(192)
embryonic 1182-4H
100
embryonic GM2
62
embryonic Kc167
(172)
embryonic S1
(126)
embryonic S3
(226)
leg disc CME L1
(197)
wing disc CME-W2
(361)
wing disc ML-DmD8
(202)
wing disc ML-DmD9
(131)
wing disc ML-DmD16-c3
(147)
wing disc ML-DmD21
(220)
wing disc ML-DmD32
(156)
haltere disc ML-DmD17-c3
(155)
eye-antennal disc ML-DmD11
(218)
antennal disc ML-DmD20-c5
(277)
mixed discs ML-DmD4-c1
(178)
CNS ML-DmBG1-c1
(266)
CNS ML-DmBG2-c2
(164)
tumorous blood cells mbn2
(132)
ovary fGS/OSS
52
ovary OSC
(110)
ovary OSS
54
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Cell Line
Expression Level
Schneider line 2 S2R+
197
Schneider line 2 Sg4
192
embryonic 1182-4H
100
embryonic GM2
62
embryonic Kc167
172
embryonic S1
126
embryonic S3
226
leg disc CME L1
197
wing disc CME-W2
361
wing disc ML-DmD8
202
wing disc ML-DmD9
131
wing disc ML-DmD16-c3
147
wing disc ML-DmD21
220
wing disc ML-DmD32
156
haltere disc ML-DmD17-c3
155
eye-antennal disc ML-DmD11
218
antennal disc ML-DmD20-c5
277
mixed discs ML-DmD4-c1
178
CNS ML-DmBG1-c1
266
CNS ML-DmBG2-c2
164
tumorous blood cells mbn2
132
ovary fGS/OSS
52
ovary OSC
110
ovary OSS
54
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Cell Line
Expression Level
Schneider line 2 S2R+
197
Schneider line 2 Sg4
192
embryonic 1182-4H
100
embryonic GM2
62
embryonic Kc167
172
embryonic S1
126
embryonic S3
226
leg disc CME L1
197
wing disc CME-W2
361
wing disc ML-DmD8
202
wing disc ML-DmD9
131
wing disc ML-DmD16-c3
147
wing disc ML-DmD21
220
wing disc ML-DmD32
156
haltere disc ML-DmD17-c3
155
eye-antennal disc ML-DmD11
218
antennal disc ML-DmD20-c5
277
mixed discs ML-DmD4-c1
178
CNS ML-DmBG1-c1
266
CNS ML-DmBG2-c2
164
tumorous blood cells mbn2
132
ovary fGS/OSS
52
ovary OSC
110
ovary OSS
54
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Moderate expression
Cell Line
Expression Level
Schneider line 2 S2R+
(197)
Schneider line 2 Sg4
(192)
embryonic 1182-4H
(100)
embryonic GM2
(62)
embryonic Kc167
(172)
embryonic S1
(126)
embryonic S3
(226)
leg disc CME L1
(197)
wing disc CME-W2
(361)
wing disc ML-DmD8
(202)
wing disc ML-DmD9
(131)
wing disc ML-DmD16-c3
(147)
wing disc ML-DmD21
(220)
wing disc ML-DmD32
(156)
haltere disc ML-DmD17-c3
(155)
eye-antennal disc ML-DmD11
(218)
antennal disc ML-DmD20-c5
(277)
mixed discs ML-DmD4-c1
(178)
CNS ML-DmBG1-c1
(266)
CNS ML-DmBG2-c2
(164)
tumorous blood cells mbn2
(132)
ovary fGS/OSS
(52)
ovary OSC
(110)
ovary OSS
(54)
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Cell Line
Expression Level
Schneider line 2 S2R+
(197)
Schneider line 2 Sg4
(192)
embryonic 1182-4H
100
embryonic GM2
62
embryonic Kc167
(172)
embryonic S1
126
embryonic S3
(226)
leg disc CME L1
(197)
wing disc CME-W2
(361)
wing disc ML-DmD8
(202)
wing disc ML-DmD9
131
wing disc ML-DmD16-c3
(147)
wing disc ML-DmD21
(220)
wing disc ML-DmD32
(156)
haltere disc ML-DmD17-c3
(155)
eye-antennal disc ML-DmD11
(218)
antennal disc ML-DmD20-c5
(277)
mixed discs ML-DmD4-c1
(178)
CNS ML-DmBG1-c1
(266)
CNS ML-DmBG2-c2
(164)
tumorous blood cells mbn2
132
ovary fGS/OSS
52
ovary OSC
110
ovary OSS
54
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Cell Line
Expression Level
Schneider line 2 S2R+
197
Schneider line 2 Sg4
192
embryonic 1182-4H
100
embryonic GM2
62
embryonic Kc167
172
embryonic S1
126
embryonic S3
226
leg disc CME L1
197
wing disc CME-W2
361
wing disc ML-DmD8
202
wing disc ML-DmD9
131
wing disc ML-DmD16-c3
147
wing disc ML-DmD21
220
wing disc ML-DmD32
156
haltere disc ML-DmD17-c3
155
eye-antennal disc ML-DmD11
218
antennal disc ML-DmD20-c5
277
mixed discs ML-DmD4-c1
178
CNS ML-DmBG1-c1
266
CNS ML-DmBG2-c2
164
tumorous blood cells mbn2
132
ovary fGS/OSS
52
ovary OSC
110
ovary OSS
54
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Cell Line
Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS
modENCODE Treatments RNA-Seq
Linear, scaled to maximum expression level
Treatment
Expression Level
extended cold, 4-day adult
33
cold shock, 4-day adult
20
heat shock, 4-day adult
84
Cadmium 50 mM 6 hrs, larvae L3
68
Cadmium 50 mM 12 hrs, larvae L3
105
Cadmium 50 mM 48 hrs, 4-day adult
88
Cadmium 100 mM 48 hrs, 4-day adult
120
Copper 0.5 mM 12 hrs, larvae L3
30
Copper 15 mM 48 hrs, 4-day adult
102
Zinc 5 mM 12 hrs, larvae L3
28
Zinc 4.5 mM 48 hrs, 4-day adult
71
Ethanol 2.5% 3 hrs, larvae L3
97
Ethanol 5% 3 hrs, larvae L3
84
Ethanol 10% 3 hrs, larvae L3
52
Caffeine 1.5 mg/ml 4 hrs, larvae L3
64
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
124
Caffeine 25 mg/ml 48 hrs, 4-day adult
44
Paraquat 5 mM 48 hrs, 4-day adult
119
Paraquat 10 mM 48 hrs, 4-day adult
99
Rotenone 2 μg 12 hrs, larvae L3
78
Rotenone 8 μg 12 hrs, larvae L3
51
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Moderate expression
Treatment
Expression Level
extended cold, 4-day adult
(33)
cold shock, 4-day adult
20
heat shock, 4-day adult
(84)
Cadmium 50 mM 6 hrs, larvae L3
(68)
Cadmium 50 mM 12 hrs, larvae L3
(105)
Cadmium 50 mM 48 hrs, 4-day adult
(88)
Cadmium 100 mM 48 hrs, 4-day adult
(120)
Copper 0.5 mM 12 hrs, larvae L3
(30)
Copper 15 mM 48 hrs, 4-day adult
(102)
Zinc 5 mM 12 hrs, larvae L3
(28)
Zinc 4.5 mM 48 hrs, 4-day adult
(71)
Ethanol 2.5% 3 hrs, larvae L3
(97)
Ethanol 5% 3 hrs, larvae L3
(84)
Ethanol 10% 3 hrs, larvae L3
(52)
Caffeine 1.5 mg/ml 4 hrs, larvae L3
(64)
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
(124)
Caffeine 25 mg/ml 48 hrs, 4-day adult
(44)
Paraquat 5 mM 48 hrs, 4-day adult
(119)
Paraquat 10 mM 48 hrs, 4-day adult
(99)
Rotenone 2 μg 12 hrs, larvae L3
(78)
Rotenone 8 μg 12 hrs, larvae L3
(51)
Expression Level Scale
Very low
Low
Moderate
Moderately high
Linear, scaled to High expression
Treatment
Expression Level
extended cold, 4-day adult
33
cold shock, 4-day adult
20
heat shock, 4-day adult
84
Cadmium 50 mM 6 hrs, larvae L3
68
Cadmium 50 mM 12 hrs, larvae L3
105
Cadmium 50 mM 48 hrs, 4-day adult
88
Cadmium 100 mM 48 hrs, 4-day adult
(120)
Copper 0.5 mM 12 hrs, larvae L3
30
Copper 15 mM 48 hrs, 4-day adult
102
Zinc 5 mM 12 hrs, larvae L3
28
Zinc 4.5 mM 48 hrs, 4-day adult
71
Ethanol 2.5% 3 hrs, larvae L3
97
Ethanol 5% 3 hrs, larvae L3
84
Ethanol 10% 3 hrs, larvae L3
52
Caffeine 1.5 mg/ml 4 hrs, larvae L3
64
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
(124)
Caffeine 25 mg/ml 48 hrs, 4-day adult
44
Paraquat 5 mM 48 hrs, 4-day adult
(119)
Paraquat 10 mM 48 hrs, 4-day adult
99
Rotenone 2 μg 12 hrs, larvae L3
78
Rotenone 8 μg 12 hrs, larvae L3
51
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Linear, scaled to Extremely high expression
Treatment
Expression Level
extended cold, 4-day adult
33
cold shock, 4-day adult
20
heat shock, 4-day adult
84
Cadmium 50 mM 6 hrs, larvae L3
68
Cadmium 50 mM 12 hrs, larvae L3
105
Cadmium 50 mM 48 hrs, 4-day adult
88
Cadmium 100 mM 48 hrs, 4-day adult
120
Copper 0.5 mM 12 hrs, larvae L3
30
Copper 15 mM 48 hrs, 4-day adult
102
Zinc 5 mM 12 hrs, larvae L3
28
Zinc 4.5 mM 48 hrs, 4-day adult
71
Ethanol 2.5% 3 hrs, larvae L3
97
Ethanol 5% 3 hrs, larvae L3
84
Ethanol 10% 3 hrs, larvae L3
52
Caffeine 1.5 mg/ml 4 hrs, larvae L3
64
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
124
Caffeine 25 mg/ml 48 hrs, 4-day adult
44
Paraquat 5 mM 48 hrs, 4-day adult
119
Paraquat 10 mM 48 hrs, 4-day adult
99
Rotenone 2 μg 12 hrs, larvae L3
78
Rotenone 8 μg 12 hrs, larvae L3
51
Expression Level Scale
Extremely high
log, scaled to maximum expression level
Treatment
Expression Level
extended cold, 4-day adult
33
cold shock, 4-day adult
20
heat shock, 4-day adult
84
Cadmium 50 mM 6 hrs, larvae L3
68
Cadmium 50 mM 12 hrs, larvae L3
105
Cadmium 50 mM 48 hrs, 4-day adult
88
Cadmium 100 mM 48 hrs, 4-day adult
120
Copper 0.5 mM 12 hrs, larvae L3
30
Copper 15 mM 48 hrs, 4-day adult
102
Zinc 5 mM 12 hrs, larvae L3
28
Zinc 4.5 mM 48 hrs, 4-day adult
71
Ethanol 2.5% 3 hrs, larvae L3
97
Ethanol 5% 3 hrs, larvae L3
84
Ethanol 10% 3 hrs, larvae L3
52
Caffeine 1.5 mg/ml 4 hrs, larvae L3
64
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
124
Caffeine 25 mg/ml 48 hrs, 4-day adult
44
Paraquat 5 mM 48 hrs, 4-day adult
119
Paraquat 10 mM 48 hrs, 4-day adult
99
Rotenone 2 μg 12 hrs, larvae L3
78
Rotenone 8 μg 12 hrs, larvae L3
51
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Moderate expression
Treatment
Expression Level
extended cold, 4-day adult
(33)
cold shock, 4-day adult
20
heat shock, 4-day adult
(84)
Cadmium 50 mM 6 hrs, larvae L3
(68)
Cadmium 50 mM 12 hrs, larvae L3
(105)
Cadmium 50 mM 48 hrs, 4-day adult
(88)
Cadmium 100 mM 48 hrs, 4-day adult
(120)
Copper 0.5 mM 12 hrs, larvae L3
30
Copper 15 mM 48 hrs, 4-day adult
(102)
Zinc 5 mM 12 hrs, larvae L3
28
Zinc 4.5 mM 48 hrs, 4-day adult
(71)
Ethanol 2.5% 3 hrs, larvae L3
(97)
Ethanol 5% 3 hrs, larvae L3
(84)
Ethanol 10% 3 hrs, larvae L3
(52)
Caffeine 1.5 mg/ml 4 hrs, larvae L3
(64)
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
(124)
Caffeine 25 mg/ml 48 hrs, 4-day adult
(44)
Paraquat 5 mM 48 hrs, 4-day adult
(119)
Paraquat 10 mM 48 hrs, 4-day adult
(99)
Rotenone 2 μg 12 hrs, larvae L3
(78)
Rotenone 8 μg 12 hrs, larvae L3
(51)
Expression Level Scale
Very low
Low
Moderate
Moderately high
log, scaled to High expression
Treatment
Expression Level
extended cold, 4-day adult
33
cold shock, 4-day adult
20
heat shock, 4-day adult
84
Cadmium 50 mM 6 hrs, larvae L3
68
Cadmium 50 mM 12 hrs, larvae L3
105
Cadmium 50 mM 48 hrs, 4-day adult
88
Cadmium 100 mM 48 hrs, 4-day adult
120
Copper 0.5 mM 12 hrs, larvae L3
30
Copper 15 mM 48 hrs, 4-day adult
102
Zinc 5 mM 12 hrs, larvae L3
28
Zinc 4.5 mM 48 hrs, 4-day adult
71
Ethanol 2.5% 3 hrs, larvae L3
97
Ethanol 5% 3 hrs, larvae L3
84
Ethanol 10% 3 hrs, larvae L3
52
Caffeine 1.5 mg/ml 4 hrs, larvae L3
64
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
124
Caffeine 25 mg/ml 48 hrs, 4-day adult
44
Paraquat 5 mM 48 hrs, 4-day adult
119
Paraquat 10 mM 48 hrs, 4-day adult
99
Rotenone 2 μg 12 hrs, larvae L3
78
Rotenone 8 μg 12 hrs, larvae L3
51
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
log, scaled to Extremely high expression
Treatment
Expression Level
extended cold, 4-day adult
33
cold shock, 4-day adult
20
heat shock, 4-day adult
84
Cadmium 50 mM 6 hrs, larvae L3
68
Cadmium 50 mM 12 hrs, larvae L3
105
Cadmium 50 mM 48 hrs, 4-day adult
88
Cadmium 100 mM 48 hrs, 4-day adult
120
Copper 0.5 mM 12 hrs, larvae L3
30
Copper 15 mM 48 hrs, 4-day adult
102
Zinc 5 mM 12 hrs, larvae L3
28
Zinc 4.5 mM 48 hrs, 4-day adult
71
Ethanol 2.5% 3 hrs, larvae L3
97
Ethanol 5% 3 hrs, larvae L3
84
Ethanol 10% 3 hrs, larvae L3
52
Caffeine 1.5 mg/ml 4 hrs, larvae L3
64
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
124
Caffeine 25 mg/ml 48 hrs, 4-day adult
44
Paraquat 5 mM 48 hrs, 4-day adult
119
Paraquat 10 mM 48 hrs, 4-day adult
99
Rotenone 2 μg 12 hrs, larvae L3
78
Rotenone 8 μg 12 hrs, larvae L3
51
Expression Level Scale
Very low
Low
Moderate
Moderately high
High
Very high
Extremely high
Heatmap
Treatment
Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
A cluster of genes with similar mRNA expression dynamics across development.
External Data & Images
Linkouts
- Cell culture data for RNAi and other high-throughput technologies
- Adult expression by tissue, using Affymetrix Dros2 array
Alleles & Phenotypes Summary of Allele Phenotypes Classical Alleles ( 1 ) For All Classical Alleles Show Allele of
janA Class Mutagen Stocks Known lesion janAA392 1 --
Alleles Carried on Transgenic Constructs
( 9 ) For All Alleles Carried on Transgenic
Constructs Show Aneuploid Aberrations Disrupted in Transgenic Constructs & Insertions
Transgenic Constructs characterization construct
Insertions Gene Ontology: Function, Process
& Cellular Component ( 1 unique term )There is no information supporting a
cellular component or molecular function term for this gene.
(Based on a review of available data before: 2006)
Terms Based on
Experimental Evidence ( 1 term ) Molecular Function ( 0 terms) Biological Process inferred from expression pattern
(assigned by UniProtKB)
Cellular Component ( 0 terms) Terms Based on Predictions or
Assertions ( 0 terms ) Sequence Ontology: Class of Gene Interactions & Pathways
Summary of Physical Interactions
protein-protein anti tag coimmunoprecipitation, peptide massfingerprinting
Summary of Genetic Interactions Interacts with Please look at the allele data
for full details of the genetic interactions
External Data Linkouts
- A database of protein and genetic interactions
- A comprehensive database of gene and protein interactions.
Protein-protein interactions (PPI) from both known and predicted PPI data sets.
Orthologs
OrthoDB Orthologs (38)
- based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
OrthoDB orthology group searches
Drosophila inclusive ortholog search
Dipteran inclusive ortholog search
Insect inclusive ortholog search
Arthropod inclusive ortholog search
Metazoa inclusive ortholog search
Orthologs in Drosophila Species
(EOG6BZNP6 )
Drosophila melanogaster
fruit fly
Drosophila pseudoobscura pseudoobscura
Y
Orthologs in non-Drosophila Dipterans
(EOG6FTW92 )
Aedes aegypti
Yellow fever mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects
(EOG6SJ4C4 )
Apis mellifera
Western honey bee
Amel\GB49097
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG019927
Atta cephalotes
Leafcutter ant
Acep\ACEP20639
Harpegnathos saltator
Jerdons jumping ant
Hsal\HSAL12774
Linepithema humile
Argentine ant
Lhum\LH12637
Pogonomyrmex barbatus
Red harvester ant
Pbar\PB19705
Acyrthosiphon pisum
Pea aphid
Pediculus humanus
Human body louse
Tribolium castaneum
Red flour beetle
Orthologs in non-Insect Arthropods
(EOG6KSN32 )
Ixodes scapularis
Deer tick
Ixodes scapularis
Deer tick
Orthologs in non-Arthropod Metazoa
(EOG6FRCNX )
Caenorhabditis elegans
Nematode
Y
Strongylocentrotus purpuratus
Purple sea urchin
Y
Xenopus tropicalis
Western clawed frog
Y
Xenopus tropicalis
Western clawed frog
Y
Gallus gallus
Domestic chicken
Y
Gallus gallus
Domestic chicken
Y
Mus musculus
House mouse
Y
Rattus norvegicus
Norway rat
Y
Human Orthologs (1)AAA Orthologs (11)
based on analysis using Dmel annotation version 4.3
Drosophila pseudoobscura pseudoobscura
Stocks & Reagents Stocks Listed in FlyBase ( 5 )Bloomington VDRC Genomic Clones ( 1 )Please Note FlyBase no
longer curates genomic clone accessions so this list
may not be complete
cDNA Clones ( 37 )Please Note This section lists
cDNAs and ESTs that fall within the genomic extent
of the gene model, which may include cDNAs and ESTs
of genes within introns, or of overlapping genes.
Please see
GBrowse for alignment of the cDNAs and ESTs
to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones Other clones cDNA Clones, End Sequenced
(ESTs) BDGP DGC clones Other clones RNAi & Array Information Linkouts
- Results from RNAi screens.
- GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Other Information Discoverer Etymology Identification Relationship to Other Genes Source for database identity of Source for database merge of Source for merge of: janA BcDNA:AT12574
Additional comments Source for merge of janA BcDNA:AT12574 was shared cDNA (AT12574) (date:030530).
Other Comments Expression is enriched in embryonic gonads.
The molecular organization of the 'rp49-Sry-jan' gene cluster, including gene order, direction of transcription and partial overlap of the
janA and
janB genes is strictly conserved between
D.melanogaster and
D.pseudoobscura.pseudoobscura . In
D.melanogaster the translation initiation codons of the divergently transcribed
Sry-β and
janA are separated by only 378bp, whereas the corresponding distance is only 176bp in
D.pseudoobscura.pseudoobscura . Promoter analysis reveals that despite the physical proximity of the two genes, their transcription is regulated by separate cis-acting sequences.
Analysis of the expression of a number of
janB -
Ecol\lacZ constructs shows that the testis-specific expression of
janB is mediated by a short DNA sequence (from -174 to +107bp) that is located entirely within the last exon of the upstream, partially overlapping,
janA gene. The presence in cis of an active
janA gene leads to a reduced accumulation of
janB -
Ecol\lacZ hybrid RNA, supporting the hypothesis that
janA transcription interferes with the function of the
janB cis-regulatory elements.
janA and
janB , two partially overlapping genes transcribed in the same direction, have been cloned and sequenced, and their expression patterns have been analysed.
One of two partially overlapping genes, janA and janB, regulate the expression of somatic sex differentiation. janA is expressed in a complex way in both males and females; janB is only expressed in males (Yanicostas, Vincent and Lepesant, 1989).
External Crossreferences & Linkouts
Sequence Crossreferences
- A searchable database of RefSeq genes.
Other Crossreferences
domains - A database of protein families, domains, and functional sites
- Patterns of gene expression in Drosophila embryogenesis
Linkouts
- A database of protein and genetic interactions
- A comprehensive database of gene and protein interactions.
- Results from RNAi screens.
- Cell culture data for RNAi and other high-throughput technologies
- Adult expression by tissue, using Affymetrix Dros2 array
- Integrated genomics database for Drosophila, Anopheles, and C.elegans
- GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents
Protein-protein interactions (PPI) from both known and predicted PPI data sets.
- Data generated by the modENCODE project.
- A database of transcriptional regulatory elements.
Synonyms & Secondary IDs
( 9 )Reported As Symbol Synonym Name Synonym Secondary FlyBase
IDs References ( 48 )Generate a list of List References by type
Recent research papers (0)
All research papers listed in FlyBase were published before 2011