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General Information
Symbol
Dmel\Jra
Species
D. melanogaster
Name
Jun-related antigen
Annotation Symbol
CG2275
Feature Type
FlyBase ID
FBgn0001291
Gene Model Status
Stock Availability
Gene Snapshot
In progress.Contributions welcome.
Also Known As
jun, Djun, D-Jun, AP-1, c-Jun
Key Links
Genomic Location
Cytogenetic map
Sequence location
2R:10,096,480..10,098,556 [+]
Recombination map
2-62
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
Belongs to the bZIP family. Jun subfamily. (P18289)
Summaries
Gene Group (FlyBase)
BASIC LEUCINE ZIPPER TRANSCRIPTION FACTORS -
The basic leucine zipper (bZIP) transcription factors are sequence-specific DNA-binding proteins that regulate transcription. They are characterized by a 60-80 amino acid bZIP domain: a basic DNA binding domain followed by a leucine zipper dimerization domain. (Adapted from FBrf0152056).
Protein Function (UniProtKB)
Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3' (PubMed:1696724, PubMed:2116361). Plays a role in dorsal closure (PubMed:9224723).
(UniProt, P18289)
Summary (Interactive Fly)
transcription factor - basic leucine zipper - cooperates with the ETS domain protein Pointed to induce R7 fate in the developing eye - normal dendrite growth in Drosophila motor neurons requires the AP-1 (a Fos, Jun heterodimer) transcription factor
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
2

Please see the GBrowse view of Dmel\Jra or the JBrowse view of Dmel\Jra for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
gene_with_stop_codon_read_through ; SO:0000697
Stop-codon suppression (UAA) postulated; FBrf0216884
Gene model reviewed during 5.44
Gene model reviewed during 5.49
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0088411
1525
289
FBtr0088410
1565
289
FBtr0330606
1525
372
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0087499
31.0
289
10.06
FBpp0087498
31.0
289
10.06
FBpp0303456
39.9
372
4.59
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

289 aa isoforms: Jra-PA, Jra-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
289 (aa); 40 (kD observed)
Comments
External Data
Subunit Structure (UniProtKB)
Heterodimer with kay/Fra (PubMed:1696724, PubMed:2116361). The kay-Jra complex is bound more stably to the AP-1 site than either of the two proteins alone (PubMed:2116361). Interacts with Atf3; the interaction enhances the DNA-binding activity of Atf3 (PubMed:20023169).
(UniProt, P18289)
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Jra using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (36 terms)
Molecular Function (6 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
inferred from physical interaction with UniProtKB:A8MPH9
(assigned by UniProt )
inferred from physical interaction with FLYBASE:chm; FB:FBgn0028387
inferred from physical interaction with FLYBASE:Atf3; FB:FBgn0028550
inferred from physical interaction with FLYBASE:Cka; FB:FBgn0044323
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000894784
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000894784
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000894785
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000894785
(assigned by GO_Central )
Biological Process (25 terms)
Terms Based on Experimental Evidence (11 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:bsk; FB:FBgn0000229
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:bsk; FB:FBgn0000229
inferred from genetic interaction with FLYBASE:hep; FB:FBgn0010303
inferred from genetic interaction with FLYBASE:Rac1; FB:FBgn0010333
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:Rel; FB:FBgn0014018
inferred from mutant phenotype
Terms Based on Predictions or Assertions (16 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000894785
(assigned by GO_Central )
non-traceable author statement
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000894784
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000894785
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000894784
(assigned by GO_Central )
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000894785
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000894785
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000894785
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000894785
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000894785
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000894785
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000894784
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000894785
(assigned by GO_Central )
Cellular Component (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000894784
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000894784
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000894784
(assigned by GO_Central )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Jra expression is generally consistent over this time period, with a peak at 0h APF.
Jra transcript is expressed in salivary glands from 18 hours prior to puparium formation to 12 hours APF. Expression peaks from the middle of the late larval ecdysone pulse though 2 hours APF.
Jra transcripts are detected at a relatively constant level throughout development on northern blots. In situ hybridization shows that they are expressed uniformly at a low level in all cell types.
Jra transcripts are observed throughout development at relatively constant levels on northern blots. By in situ hybridization, they are found in embyros in all tissues.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
epidermis of abdomen

Comment: reference states approximately 24h APF

histoblast

Comment: reference states approximately 24h APF

Additional Descriptive Data
Jra protein is expressed in the same motor neurons that express the Scer\GAL4futsch-C380 driver.
Jra protein expression is widespread during embryogenesis. One tissue showing elevated Jra expression is the amnioserosa. During and following germ band retraction, the cells of the dorsal epidermis show elevated levels of Jra protein. The highest levels are found in the cells at the leading dorsal edge of the epidermis which are involved in the process of dorsal closure. Expression remains high in these cells throughout the process of dorsal closure. Elevated expression is also observed along the cephalic furrow.
Jra protein is expressed posterior to the morphogenetic furrow in all cells entering the ommatidial cluster including photoreceptor cells, cone cells and the mystery cell. Its expression is transient. It is expressed in the cells as they are newly recruited to the ommatidial cluster and for 3-4 columns posteriorly.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Jra in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 6 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 29 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Jra
Transgenic constructs containing regulatory region of Jra
Deletions and Duplications ( 15 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
12 of 15
Yes
Yes
12 of 15
Yes
Yes
9 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
12 of 15
Yes
Yes
11 of 15
No
Yes
9 of 15
No
Yes
1 of 15
No
No
Rattus norvegicus (Norway rat) (5)
11 of 13
Yes
Yes
9 of 13
No
Yes
8 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (4)
10 of 12
Yes
Yes
6 of 12
No
Yes
5 of 12
No
Yes
5 of 12
No
Yes
Danio rerio (Zebrafish) (5)
12 of 15
Yes
Yes
12 of 15
Yes
Yes
10 of 15
No
Yes
6 of 15
No
Yes
6 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
4 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (9)
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (2)
3 of 15
Yes
Yes
1 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
2 of 12
Yes
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190D4T )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091509CA )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0F4B )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0F3W )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0N0L )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 3 )
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Heterodimer with kay/Fra (PubMed:1696724, PubMed:2116361). The kay-Jra complex is bound more stably to the AP-1 site than either of the two proteins alone (PubMed:2116361). Interacts with Atf3; the interaction enhances the DNA-binding activity of Atf3 (PubMed:20023169).
    (UniProt, P18289 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2R
    Recombination map
    2-62
    Cytogenetic map
    Sequence location
    2R:10,096,480..10,098,556 [+]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    46E4-46E5
    Limits computationally determined from genome sequence between P{lacW}Adamk13906&P{EP}Pka-R2EP2162 and P{PZ}14-3-3ζ07103
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    46E-46E
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (15)
    Genomic Clones (26)
    cDNA Clones (38)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for database merge of
    Source for merge of: Jra l(2)46Ef
    Additional comments
    Other Comments
    DNA-protein interactions: genome-wide binding profile assayed for Jra protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069).
    S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
    dsRNA made from templates generated with primers directed against this gene results in dorsal-closure defects in 79.4% of injected embryos.
    dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
    Clonal analysis reveals that loss of function mutants cause defects in R3 induction and planar polarity determination, whereas gain of function mutants induce the R3 fate and associated polarity phenotypes.
    Jra acts downstream of fz/dsh signaling in R3 specification and planar polarity determination. Jra is one of the transcription factors that mediates the effects of fz in planar polarity generation.
    In vitro protein binding assays demonstrate kay is a poor candidate for a transcriptional activator acting through the Ubx cAMP response element (CRE).
    Jra in the embryo is a downstream target of the bsk signal transduction pathway during dorsal closure formation. The function of the bsk/Jra pathway is to control the localised expression of dpp. Both in the embryo and during photoreceptor cell determination Jra is not regulated by a pathway that involved rl. Jra is required for the initiation of dorsal closure (controls the organisation of the leading edge cells), but not for embryonic segmentation or photoreceptor cell differentiation in the eye.
    Transcription factors Jra and aop are required for dorsal closure. Results suggest that the bsk pathway governs dorsal closure at least partially by regulating dpp expression via phosphorylation of Jra and aop. Jra function is not required for the specification of cell fate in the eye.
    Jra and pntP2 do not cooperate during midline glia development.
    Jra is a substrate for rl, part of the receptor tyrosine kinase signal transduction pathway which triggers photoreceptor differentiation during eye development. Mutant analysis implicates Jra phosphorylation in the choice between neuronal and non-neuronal fate during eye development.
    The DebA upstream region contains a binding site for the Jra/kay (AP-1) protein complex, which negatively regulates its transcription.
    Jra cooperates with the ETS domain pnt gene product to act on common target genes which induce photoreceptor R7 fate in the developing eye. phyl might be one of the target genes.
    Jra is required downstream of the sev signalling pathway for development in the eye.
    Promoter deletion analysis of Jra-Ecol\CAT fusion constructs indicates that multiple cis-acting elements in the promoter region and the 5' non-coding region of the transcription unit control Jra expression.
    The AP-1 complex encodes two proteins that have functional and structural properties in common with mammalian Fos and Jun proto-oncogene products; kay and Jra, respectively. The biochemical properties of the Jra gene product have been examined in vitro and the expression pattern in developing embryos studied.
    The potential interplay of Jra with kay may play an important role in cell-type specific transcription during embryonic development.
    Isolated from a genomic library using a human jun cDNA as a probe.
    Jra has been cloned, sequenced, and its expression pattern analysed.
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 76 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Flygut - An atlas of the Drosophila adult midgut
    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    KEGG Genes - Molecular building blocks of life in the genomic space.
    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
    modMine - A data warehouse for the modENCODE project
    SignaLink - A signaling pathway resource with multi-layered regulatory networks.
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DPiM - Drosophila Protein interaction map
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (40)
    Reported As
    Symbol Synonym
    Jra
    (Adhikari et al., 2019, Chai et al., 2019, Shokri et al., 2019, Akishina et al., 2018, Bischof et al., 2018, Hall et al., 2018, Mondal et al., 2018, Mortensen et al., 2018, Tsai et al., 2018, Yang et al., 2018, Akishina et al., 2017, Houtz et al., 2017, Jonchère et al., 2017, Monsanto-Hearne et al., 2017, Purice et al., 2017, Ragheb et al., 2017, Ray et al., 2017, Transgenic RNAi Project members, 2017-, Kwon et al., 2016, Mishra et al., 2016, Saadin and Starz-Gaiano, 2016, Yasin et al., 2016, Lim et al., 2015, Liu and Zhang, 2015, Merkling et al., 2015, Schertel et al., 2015, Vedanayagam and Garrigan, 2015, Macagno et al., 2014, Wong et al., 2014, Carter, 2013, Humphreys et al., 2013, Macdonald et al., 2013, Ríos-Barrera and Riesgo-Escovar, 2013, Spokony and White, 2013.7.5, Bossing et al., 2012, Chakrabarti et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Lim et al., 2012, Ling et al., 2012, Spedale et al., 2012, Tokusumi et al., 2012, Weber et al., 2012, Friedman et al., 2011, Grimberg et al., 2011, Jungreis et al., 2011, Jungreis et al., 2011, Weake et al., 2011, Campos et al., 2010, Suganuma et al., 2010, Bossuyt et al., 2009, Tokusumi et al., 2009, Bates et al., 2008, Carrera et al., 2008, de Wit et al., 2008, Lee et al., 2008, Stielow et al., 2008, Xi et al., 2008, Zhao et al., 2008, Christensen and Cook, 2007.5.8, Curtis et al., 2007, Kim et al., 2007, Lecuyer et al., 2007, Tadros et al., 2007, Moorman et al., 2006, Moorman et al., 2006, Sandmann et al., 2006, Stroschein-Stevenson et al., 2006, Kim et al., 2005, Mace et al., 2005, Pickeral et al., 2000)
    l(2)46Ef
    Secondary FlyBase IDs
    • FBgn0002124
    • FBgn0015487
    • FBgn0017591
    • FBgn0023037
    Datasets (1)
    Study focus (1)
    Experimental Role
    Project
    Project Type
    Title
    • transgene_used
    Protein profiling reveals five principal chromatin types in Drosophila cells.
    References (409)