FB2019_05, released Oct 15, 2019

Gene: Dmel\kay

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General Information
Symbol
Dmel\kay
Species
D. melanogaster
Name
kayak
Annotation Symbol
CG33956
Feature Type
protein_coding_gene
FlyBase ID
FBgn0001297
Gene Model Status
Current
Stock Availability
34 publicly available
Gene Snapshot
kayak (kay) encodes a transcription factor involved in multiple biological processes including cell polarity, wound healing, germ cell and eye development and cell cycle. [Date last reviewed: 2019-03-14]
Other Summaries
Also Known As
Fos, Dfos, AP-1, D-Fos, AP1
Key Links
Genomic Location
Cytogenetic map
99B10-99C1
Sequence location
3R:29,765,995..29,794,113 [+]
Recombination map
3-99
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the bZIP family. Fos subfamily. (P21525A8MPH9)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; protein heterodimerization activity; repressing transcription factor binding; sequence-specific DNA binding
Predictions / Assertions
RNA polymerase II proximal promoter sequence-specific DNA binding
Summaries
Gene Group (FlyBase)
BASIC LEUCINE ZIPPER TRANSCRIPTION FACTORS -
The basic leucine zipper (bZIP) transcription factors are sequence-specific DNA-binding proteins that regulate transcription. They are characterized by a 60-80 amino acid bZIP domain: a basic DNA binding domain followed by a leucine zipper dimerization domain. (Adapted from FBrf0152056).
Pathway (FlyBase)
Positive Regulators of Imd Signaling Pathway -
Positive regulators of the immune deficiency (Imd) pathway result in the increased activity of the NFκB-like transcription factor Rel in the nucleus. (Adapted from FBrf0224587 and FBrf0238555.)
Protein Function (UniProtKB)
Developmentally regulated transcription factor AP-1 binds and recognizes the enhancer DNA sequence: 5'-TGA[CG]TCA-3'. May play a role in the function or determination of a particular subset of cells in the developing embryo. It is able to carry out its function either independently of or in conjunction with Jra.
(UniProt, P21525)
Developmentally regulated transcription factor AP-1 binds and recognizes the enhancer DNA sequence: 5'-TGA[CG]TCA-3'. May play a role in the function or determination of a particular subset of cells in the developing embryo. It is able to carry out its function either independently of or in conjunction with Jra.
(UniProt, A8MPH9)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
kay: kayak
Homozygous lethal; embryo open dorsally.
sro: shroud
Embryonic lethal. No differentiation of cuticle and mouthparts.
Summary (Interactive Fly)
transcription factor - basic leucine zipper - regulates dorsal closure - also required downstream from Decapentaplegic signaling for the regulation of in the midgut - Fos and Jun potentiate individual release sites and mobilize the reserve synaptic-vesicle pool at the Drosophila larval motor synapse
Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
5

Please see the GBrowse view of Dmel\kay or the JBrowse view of Dmel\kay for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.55
Gene model reviewed during 5.39
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.49
Gene model reviewed during 5.56
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
kay-RA
FBtr0099989
NM_001032407
3585
595
kay-RB
FBtr0099990
NM_001032406
3194
546
kay-RD
FBtr0099988
NM_001032408
4248
722
kay-RF
FBtr0290076
NM_001032405
4574
755
kay-RG
FBtr0339165
NM_001300662
3738
646
Additional Transcript Data and Comments
Reported size (kB)
3.65 (northern blot)
(Perkins et al., 1990)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
kay-PA
FBpp0084844
62.8
595
5.62
NP_001027579
AAZ83992
kay-PB
FBpp0084846
57.5
546
6.32
NP_001027578
AAZ83993
kay-PD
FBpp0099941
78.3
722
7.22
NP_001027580
AAZ83991
kay-PF
FBpp0288515
80.6
755
6.77
NP_001027577
AAZ83994
kay-PG
FBpp0308309
68.6
646
6.04
NP_001287591
AHN57590
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
595 (aa); 70 (kD observed)
(Perkins et al., 1990)
Comments
External Data
Subunit Structure (UniProtKB)
Homodimer. Heterodimer with Jra. The kay-Jra heterodimer binds more stably to the AP-1 site than either of the two proteins alone.
(UniProt, P21525, A8MPH9)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\kay using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (33 terms)
Molecular Function (8 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
DNA binding
inferred from direct assay
(Perkins et al., 1990)
DNA-binding transcription activator activity, RNA polymerase II-specific
inferred from direct assay
(Miotto et al., 2006)
DNA-binding transcription factor activity, RNA polymerase II-specific
inferred from direct assay
(Perkins et al., 1990)
protein binding
inferred from physical interaction with FLYBASE:inferred from high throughput direct assayC1; FB:FBgn0015805
(Miotto et al., 2006)
inferred from physical interaction with FLYBASE:chm; FB:FBgn0028387
(Miotto et al., 2006)
inferred from physical interaction with UniProtKB:P18289
(assigned by UniProt )
(Perkins et al., 1990)
inferred from physical interaction with FLYBASE:Cka; FB:FBgn0044323
(Chen et al., 2002)
protein heterodimerization activity
inferred from physical interaction with FLYBASE:Jra; FB:FBgn0001291
(Perkins et al., 1990)
repressing transcription factor binding
inferred from physical interaction with FLYBASE:vri; FB:FBgn0016076
(Ling et al., 2012)
sequence-specific DNA binding
inferred from direct assay
(Hyun et al., 2006)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
RNA polymerase II proximal promoter sequence-specific DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN001156258
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (22 terms)
Terms Based on Experimental Evidence (21 terms)
CV Term
Evidence
References
collateral sprouting of injured axon
inferred from mutant phenotype
(Xiong et al., 2010)
compound eye development
inferred from mutant phenotype
(Cerrato et al., 2006)
dendrite morphogenesis
inferred from mutant phenotype
(Iyer et al., 2013)
dorsal closure
inferred from mutant phenotype
(Grima et al., 2008)
embryo development ending in birth or egg hatching
inferred from mutant phenotype
(assigned by UniProt )
(Perkins et al., 1990)
establishment or maintenance of cell polarity
inferred from mutant phenotype
(assigned by BHF-UCL )
(King et al., 2011)
germ cell development
inferred from mutant phenotype
(Jemc et al., 2012)
imaginal disc fusion, thorax closure
inferred from mutant phenotype
(Cerrato et al., 2006)
locomotor rhythm
inferred from mutant phenotype
(Ling et al., 2012)
ovarian follicle cell migration
inferred from mutant phenotype
(Dequier et al., 2001)
positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
inferred from high throughput mutant phenotype
(Kleino et al., 2005)
positive regulation of border follicle cell migration
inferred from genetic interaction with FLYBASE:Pvr; FB:FBgn0032006
(Mathieu et al., 2007)
positive regulation of peptidoglycan recognition protein signaling pathway
inferred from high throughput mutant phenotype
(Kleino et al., 2005)
positive regulation of transcription by RNA polymerase II
inferred from direct assay
(Perkins et al., 1990)
R3/R4 cell fate commitment
inferred from mutant phenotype
(Weber et al., 2008)
regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle
inferred from mutant phenotype
(Hyun et al., 2006)
response to wounding
inferred from mutant phenotype
(Ramet et al., 2002)
second mitotic wave involved in compound eye morphogenesis
inferred from mutant phenotype
(Hyun et al., 2006)
synaptic growth at neuromuscular junction
inferred from genetic interaction with FLYBASE:Jra; FB:FBgn0001291
(Franciscovich et al., 2008)
wing disc development
inferred from mutant phenotype
(Hyun et al., 2006)
wound healing
inferred from mutant phenotype
(Bosch et al., 2005, Ramet et al., 2002)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
dorsal closure
traceable author statement
(Harden, 2002, Noselli and Agnes, 1999)
establishment of planar polarity
non-traceable author statement
(Mlodzik, 2002)
R3/R4 cell fate commitment
traceable author statement
(Mlodzik, 2002)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
cytoplasm
inferred from direct assay
(Reed et al., 2001)
nucleus
inferred from direct assay
(Woolner et al., 2005, Reed et al., 2001, Perkins et al., 1990)
transcription factor complex
inferred from physical interaction with FLYBASE:Jra; FB:FBgn0001291
(Perkins et al., 1990)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
nucleus
inferred from biological aspect of ancestor with PANTHER:PTN001156258
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism | ubiquitous | uniform

Comment: kay-RA

(Souid and Yanicostas, 2003)
embryonic stage 4 -- 7
amnioserosa anlage

Comment: kay-RA and kay-RB

(Souid and Yanicostas, 2003)
embryonic stage 6 -- 7
cephalic furrow

Comment: kay-RA

(Souid and Yanicostas, 2003)
ventral ectoderm

Comment: kay-RA

(Souid and Yanicostas, 2003)
posterior transverse furrow

Comment: kay-RA

(Souid and Yanicostas, 2003)
embryonic stage 7 -- 8
dorsal ectoderm
(Fisher et al., 2012)
embryonic stage 7 -- 10
amnioserosa

Comment: kay-RA and kay-RB

(Souid and Yanicostas, 2003)
embryonic stage 9 -- 10
amnioserosa
(Fisher et al., 2012)
amnioserosa primordium
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
embryonic stage 9 -- 12
head | restricted

Comment: reference states 4-8 hr AEL

(Perkins et al., 1990)
embryonic stage 10 -- 11
stomodeal invagination

Comment: kay-RB

(Souid and Yanicostas, 2003)
embryonic stage 10 -- 12
embryonic leading edge cell | intense

Comment: kay-RA and kay-RB

(Souid and Yanicostas, 2003)
embryonic stage 10 -- 14
epithelium | faint

Comment: kay-RA

(Souid and Yanicostas, 2003)
embryonic stage 11 -- 12
amnioserosa
(Fisher et al., 2012)
plasmatocyte primordium

Comment: reported as plasmatocytes anlage

(Fisher et al., 2012)
embryonic stage 13 -- 14
embryonic midgut constriction 1 | precursor

Comment: kay-RB

(Souid and Yanicostas, 2003)
embryonic stage 13 -- 16
embryonic precursor of adult hindgut
(Fisher et al., 2012)
amnioserosa
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval midgut interstitial cell
(Fisher et al., 2012)
yolk nucleus
(Fisher et al., 2012)
embryonic stage 15 -- 16
embryonic midgut constriction 1

Comment: kay-RB

(Souid and Yanicostas, 2003)
adult stage | female & oogenesis stage S9
centripetally migrating follicle cell

Comment: NOT polar follicle cell; kay-RB

(Souid and Yanicostas, 2003)
adult stage | femaleoogenesis stage S5 -- S10
nurse cell

Comment: kay-RA

(Souid and Yanicostas, 2003)
adult stage | female & oogenesis stage S10A
border follicle cell

Comment: early stage 10A only; kay-RB

(Souid and Yanicostas, 2003)
adult stage | female & oogenesis stage S10B
border follicle cell | subset

Comment: early stage 10B; kay-RB

(Souid and Yanicostas, 2003)
adult stage | femaleoogenesis stage S10B -- S12
border follicle cell | anterior | dorsal | subset

Comment: late stage 10B; kay-RB

(Souid and Yanicostas, 2003)
adult stage | female & oogenesis stage S13
polar follicle cell | posterior

Comment: kay-RB

(Souid and Yanicostas, 2003)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
(Perkins et al., 1990)
amnioserosa
(Perkins et al., 1990)
dorsal ectoderm
(Perkins et al., 1990)
embryonic stage 15
muscle attachment site
(Perkins et al., 1990)
eo neuron
(Perkins et al., 1990)
presumptive embryonic/larval peripheral nervous system | restricted
(Perkins et al., 1990)
anal pad
(Perkins et al., 1990)
embryonic/larval midgut
(Perkins et al., 1990)
multidendritic neuron
(Perkins et al., 1990)
embryonic/larval hindgut
(Perkins et al., 1990)
prepupal stage P4(i)
embryonic/larval salivary gland

Comment: 10-12 hr APF

(Lehmann et al., 2002)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism

Comment: kay-RA and kay-RB transcripts

(Souid and Yanicostas, 2003)
third instar larval stage -- pharate adult stage P9
organism
(Sekyrova et al., 2010)
adult stage | male
organism | faint

Comment: kay-RA and kay-RB transcripts

(Souid and Yanicostas, 2003)
adult stage | female
organism

Comment: kay-RA and kay-RB transcripts

(Souid and Yanicostas, 2003)
ovary

Comment: kay-RA and kay-RB transcripts

(Souid and Yanicostas, 2003)
Additional Descriptive Data
kay expression is generally consistent over this time period, with slight peaks at 6h and 24h APF.
(Sekyrova et al., 2010)
kay transcripts are differentally expressed during oogenesis. kay-RA transcript is expressed in nurse cells from oogenesis stage 5 through stage 9. kay-RB transcription is first detected at oogenesis stage 9 in migrating columnar cells, with weak to no expression in anterior stretching cells posterior follicle cells. During early stage 10A kay-RB transcript levels decrease sharply and is transiently restricted to the anterior-most columnar cells before disappearing completely at mid-stage 10A. At early stage 10B, kay-RB transcript is strongly expressed in anterior stretched cells. From late stage 10B, kay-RB transcript accumulates to a high level in two rows of dorsal anterior follicle cells. During stage 13,kay-RB transcript is strongly expressed in a population of approximately 15 follicle cells located at the posterior pole of the oocyte. kay-RA transcript is uniformly distributed in preblastoderm embryos; this transcript is maternally deposited. kay-RB, by contrast, is not maternally deposited. Both kay transcripts are zygotically expressed at embryonic stage 4, in the amnioserosa anlage, and both continue to be expressed in the amnioserosa, and later in the embryonic leading edge cells. kay-RA is additionally expressed in the cephalic and posterior transverse furrows during gastrulation. kay-RB is additionally expressed in the stomodeal invagination, and in the cells that go on to form midgut constriction 1.
(Souid and Yanicostas, 2003)
kay transcript is expressed strongly in salivary glands at the beginning of the prepupal ecdysone pulse (10 hr APF).
(Lehmann et al., 2002)
kay transcripts are detected at a low level on northern blots in 4-8hr embryos and at a higher level in 8-12 and 12-16hr embryos. kay expression was shown to be restricted to certain cell types by in situ hybridization. It is expressed in cells of the head that are thought to be mesodermal soon after gastrulation (4-5hr) and persists until 8hr of embryogenesis. Early expression is also observed in the dorsal ectoderm and the amnioserosa. After ~11hr of embryogenesis, expression is restricted to a subset of PNS cells. They localize near the lateral chordotonal organs and may be the es (extrasensory) or md (multiple dendritic) neurons. Later expression is also observed in the muscle attachment sites, midgut, hindgut, and anal pads.
(Perkins et al., 1990)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
oogenesis stage S11
dorsal appendage | restricted
(Boyle et al., 2010)
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11
amnioserosa
• nucleus
(Reed et al., 2001)
amnioserosa

Comment: weakly expressed in nucleus at this stage

(Reed et al., 2001)
larval stage
motor neuron
(Sanyal et al., 2003)
aCC neuron
(Sanyal et al., 2003)
RP2 motor neuron
(Sanyal et al., 2003)
RP3 motor neuron
(Sanyal et al., 2003)
RP5 motor neuron
(Sanyal et al., 2003)
Additional Descriptive Data
kay protein is expressed in stretch cells, floor cells and the first row of roof cells of the dorsal appendage primoridium.
(Boyle et al., 2010)
kay protein is expressed in the same motor neurons that express the Scer\GAL4futsch-C380 driver.
(Sanyal et al., 2003)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
cytoplasm
inferred from direct assay
(Reed et al., 2001)
nucleus
inferred from direct assay
(Woolner et al., 2005, Reed et al., 2001, Perkins et al., 1990)
transcription factor complex
inferred from physical interaction with FLYBASE:Jra; FB:FBgn0001291
(Perkins et al., 1990)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\kay in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 26 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 37 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of kay
Transgenic constructs containing regulatory region of kay
Deletions and Duplications ( 8 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
cell lethal | somatic clone
lethal, with Scer\GAL4T80
lethal, with Scer\GAL4Tub.PU
lethal, with Scer\GAL4Ubi.PU
lethal (with kay1)
lethal (with kay2)
lethal | embryonic stage | recessive
lethal | male limited, with Scer\GAL4Bx-MS1096
lethal | male limited | cold sensitive, with Scer\GAL4Bx-MS1096
lethal | pharate adult stage
lethal | recessive
lethal - all die before end of embryonic stage, with Scer\GAL4C-765
lethal - all die before end of embryonic stage | recessive
lethal - all die before end of embryonic stage | recessive | heat sensitive
lethal - all die before end of pupal stage, with Scer\GAL4en-e16E
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
partially lethal, with Scer\GAL4sd.PU
partially lethal - majority live, with Scer\GAL4αTub84B.PL
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4αTub84B.PL
Sterility
Allele
fertile
Other Phenotypes
Allele
developmental rate defective | larval stage, with Scer\GAL4T80
increased cell death, with Scer\GAL4en-e16E
increased cell death, with Scer\GAL4GMR.PF
locomotor behavior defective | adult stage | male limited
locomotor rhythm defective, with Dcr-2UAS.cDa, Scer\GAL4P2.4.Pdf
locomotor rhythm defective, with Scer\GAL4P2.4.Pdf
long lived | male limited
mitotic cell cycle defective, with Scer\GAL4en-e16E
mitotic cell cycle defective, with Scer\GAL4T80
neuroanatomy defective
neuroanatomy defective, with Scer\GAL4221
neuroanatomy defective, with Scer\GAL4elav-C155
neuroanatomy defective, with Scer\GAL4ey-OK107
neuroanatomy defective, with Scer\GAL4futsch-C380, Scer\GAL80ChAT.3.3P
neuroanatomy defective, with Scer\GAL4ppk.1.9
neuroanatomy defective | conditional, with Scer\GAL4tey-5053A
neuroanatomy defective | somatic clone, with Scer\FLP1UAS.cUa, Scer\GAL4Act.PU, Scer\GAL4eve.RRK
neuroanatomy defective | third instar larval stage, with Scer\GAL4ppk.PU
neurophysiology defective, with Scer\GAL4elav-C155
planar polarity defective
planar polarity defective, with Scer\GAL4h-1J3
planar polarity defective, with Scer\GAL4hs.2sev
planar polarity defective, with Scer\GAL4pnr-MD237
planar polarity defective | somatic clone
planar polarity defective | somatic clone, with Scer\GAL4Act.PU
some die during embryonic stage, with Scer\GAL4C-765
some die during embryonic stage | recessive
some die during embryonic stage | recessive | heat sensitive
some die during pupal stage, with Scer\GAL4en-e16E
some die during pupal stage, with Scer\GAL4pnr-MD237
starvation stress response defective
temperature response defective
visible
visible, with kay1, kay2
visible, with kay1, kayhs.PZ
visible, with kay1/kay2
visible, with kay2, kayhs.PZ
visible, with Scer\GAL4ap-md544
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4ey.3.5.Exel
visible, with Scer\GAL4ey.PH
visible, with Scer\GAL4GMR.PF
visible, with Scer\GAL4MZ980
visible, with Scer\GAL4pnr-MD237
visible (with kay1), with kayhs.PZ
visible (with kay2), with kayhs.PZ
visible | female limited, with Scer\GAL4Bx-MS1096
visible | female limited | cold sensitive, with Scer\GAL4Bx-MS1096
visible | recessive
wild-type
wound healing defective, with Scer\GAL4en-e16E
wound healing defective (with kay1)
wound healing defective (with kay2)
wound healing defective | partially, with Scer\GAL4en-e16E
Phenotype manifest in
Allele
abdominal anterior ventral multidendritic neuron vdaa, with Scer\GAL4ppk.1.9
abdominal tergite 6 | female
adult heart | RU486 conditional, with Scer\GAL4Hand.ΔVM.Switch
adult midgut progenitor cell, with Scer\GAL448Y
adult thorax
adult thorax, with Scer\GAL4ap-md544
adult thorax, with Scer\GAL4MZ980
adult thorax, with Scer\GAL4pnr-MD237
adult thorax | dorsal
adult thorax | dorsal, with kay1, kay2
adult thorax | dorsal, with kay1, kayhs.PZ
adult thorax | dorsal, with kay1/kay2
adult thorax | dorsal, with kay2, kayhs.PZ
adult thorax | dorsal (with kay1), with kayhs.PZ
adult thorax | dorsal (with kay2), with kayhs.PZ
anterior crossvein, with Scer\GAL4dpp.blk1
anterior crossvein, with Scer\GAL4en-e16E
axon, with Scer\GAL4ey-OK107
bouton, with Scer\GAL4BG380
bouton, with Scer\GAL4elav-C155
class IV dendritic arborizing neuron | third instar larval stage, with Scer\GAL4ppk.PU
copper cell, with Scer\GAL448Y
copper cell, with Scer\GAL4hs.PB
copper cell, with Scer\GAL4unspecified
dendrite
dendrite | somatic clone, with Scer\FLP1UAS.cUa, Scer\GAL4Act.PU, Scer\GAL4eve.RRK
dorsal appendage | maternal effect | somatic clone
egg | maternal effect | somatic clone
embryo | dorsal
embryo | dorsal closure stage
embryo | dorsal closure stage (with kay1)
embryo | dorsal closure stage (with kay2)
embryonic/first instar larval cuticle
embryonic/first instar larval cuticle, with Scer\GAL4C-765
embryonic/larval hemocyte | third instar larval stage, with Scer\GAL4Pxn.PS
embryonic dorsal epidermis
embryonic dorsal epidermis (with kay1)
embryonic dorsal epidermis (with kay2)
embryonic epidermis
embryonic epidermis | dorsal
embryonic head
embryonic ventral epidermis
eye, with Scer\GAL4ey.3.5.Exel
eye, with Scer\GAL4ey.PH
eye, with Scer\GAL4GMR.PF
eye, with Scer\GAL4h-1J3
eye, with Scer\GAL4hs.2sev
eye, with Scer\GAL4unspecified
eye photoreceptor cell, with Scer\GAL4h-1J3
eye photoreceptor cell, with Scer\GAL4hs.2sev
eye photoreceptor cell | somatic clone
follicle cell | somatic clone
imaginal disc
Kenyon cell, with Scer\GAL4ey-OK107
larval dorsal multidendritic neuron ddaC, with Scer\GAL4ppk.1.9
larval dorsal multidendritic neuron ddaD, with Scer\GAL4221
larval dorsal multidendritic neuron ddaE, with Scer\GAL4221
larval ventral multidendritic neuron vdaB, with Scer\GAL4ppk.1.9
mesothoracic cleft (with kay1)
mesothoracic cleft (with kay2)
mesothoracic tergum, with Scer\GAL4pnr-MD237
midgut interstitial cell, with Scer\GAL448Y
motor neuron, with Scer\GAL4futsch-C380, Scer\GAL80ChAT.3.3P
neuromuscular junction, with Scer\GAL4BG380
neuromuscular junction | larval stage, with Scer\GAL4elav-C155
nurse cell & nucleus | somatic clone
ommatidium
ommatidium, with Scer\GAL4GMR.PF
ommatidium, with Scer\GAL4h-1J3
ommatidium, with Scer\GAL4hs.2sev
ommatidium | somatic clone
oocyte | oogenesis stage S9 | somatic clone
oocyte | oogenesis stage S14 | somatic clone
photoreceptor cell R4 | somatic clone, with Scer\GAL4Act.PU
pigment cell, with Scer\GAL4GMR.PF
pupal thorax
RP2 motor neuron
RP2 motor neuron | somatic clone, with Scer\FLP1UAS.cUa, Scer\GAL4Act.PU, Scer\GAL4eve.RRK
salivary gland
scutellum
segmental nerve | conditional, with Scer\GAL4tey-5053A
synapse, with Scer\GAL4elav-C155
terminal bouton, with Scer\GAL4elav-C155
thorax, with Scer\GAL469B
trichogen cell, with Scer\GAL4pnr-MD237
wing
wing, with Scer\GAL4Bx-MS1096
wing, with Scer\GAL4sd.PU
wing, with Scer\GAL4sd-SG29.1
wing | female limited, with Scer\GAL4Bx-MS1096
wing | female limited | cold sensitive, with Scer\GAL4Bx-MS1096
wing | posterior, with Scer\GAL4en-e16E
wing disc
wing vein, with Scer\GAL4en-e16E
wing vein, with Scer\GAL4sd-SG29.1, kay1
wing vein, with Scer\GAL4sd-SG29.1, kayFbz.UAS
wing vein L2, with Scer\GAL4sd-SG29.1
wing vein L3, with Scer\GAL4dpp.blk1, kay1
wing vein L3, with Scer\GAL4dpp.blk1, kayFbz.UAS
wing vein L4, with Scer\GAL4sd-SG29.1
wing vein L5, with Scer\GAL4en-e16E
wing vein L5, with Scer\GAL4en-e16E, kay1
wing vein L5, with Scer\GAL4en-e16E, kayFbz.UAS
wing vein L5, with Scer\GAL4sd-SG29.1
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (15)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\FOS
5 of 15
Yes
Yes
Hsap\FOSL1
5 of 15
Yes
Yes
Hsap\FOSL2
5 of 15
Yes
Yes
 
Hsap\FOSB
4 of 15
No
Yes
Hsap\ATF2
2 of 15
No
No
Hsap\ATF3
2 of 15
No
No
 
Hsap\ATF7
2 of 15
No
No
Hsap\BATF2
2 of 15
No
Yes
Hsap\BATF3
2 of 15
No
Yes
Hsap\BATF
2 of 15
No
Yes
Hsap\CREB5
2 of 15
No
No
Hsap\JDP2
2 of 15
No
No
Hsap\ATF1
1 of 15
No
No
Hsap\CREB1
1 of 15
No
No
Hsap\CREM
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (14)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Fosl1
5 of 15
Yes
Yes
Mmus\Fosl2
5 of 15
Yes
Yes
Mmus\Fos
5 of 15
Yes
Yes
Mmus\Fosb
4 of 15
No
Yes
Mmus\Atf3
2 of 15
No
No
Mmus\Atf7
2 of 15
No
No
Mmus\Batf2
2 of 15
No
Yes
Mmus\Batf3
2 of 15
No
Yes
Mmus\Batf
2 of 15
No
Yes
Mmus\Creb5
2 of 15
No
No
Mmus\Jdp2
2 of 15
No
No
Mmus\Atf1
1 of 15
No
No
Mmus\Atf2
1 of 15
No
No
Mmus\Creb1
1 of 15
No
No
Rattus norvegicus (Norway rat) (12)
Rnor\Fosl1
4 of 13
Yes
Yes
Rnor\Fos
4 of 13
Yes
Yes
Rnor\Fosb
3 of 13
No
Yes
Rnor\Atf3
2 of 13
No
No
Rnor\Batf2
2 of 13
No
Yes
Rnor\Batf3
2 of 13
No
Yes
Rnor\Batf
2 of 13
No
Yes
Rnor\Jdp2
2 of 13
No
No
Rnor\Atf2
1 of 13
No
No
Rnor\Atf7
1 of 13
No
No
Rnor\Creb5
1 of 13
No
No
Rnor\Fosl2
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (10)
Xtro\fosl2
5 of 12
Yes
Yes
Xtro\fosb
4 of 12
No
Yes
Xtro\fosl1
3 of 12
No
Yes
Xtro\fos
3 of 12
No
Yes
Xtro\atf1
1 of 12
No
No
Xtro\atf2
1 of 12
No
No
Xtro\atf3
1 of 12
No
No
Xtro\atf7
1 of 12
No
No
Xtro\batf
1 of 12
No
Yes
Xtro\creb5
1 of 12
No
No
Danio rerio (Zebrafish) (21)
Drer\fosab
6 of 15
Yes
Yes
Drer\fosl1a
6 of 15
Yes
Yes
Drer\fosl2
6 of 15
Yes
Yes
Drer\si:ch211-153j24.3
6 of 15
Yes
Yes
Drer\fosaa
5 of 15
No
Yes
Drer\fosb
4 of 15
No
Yes
Drer\si:ch211-59d15.4
3 of 15
No
Yes
Drer\atf2
2 of 15
No
No
Drer\batf3
2 of 15
No
Yes
Drer\batf
2 of 15
No
Yes
Drer\creb5b
2 of 15
No
No
Drer\fosl1b
2 of 15
No
Yes
Drer\jdp2a
2 of 15
No
No
Drer\jdp2b
2 of 15
No
No
Drer\atf1
1 of 15
No
No
Drer\atf3
1 of 15
No
No
Drer\atf7a
1 of 15
No
No
Drer\atf7b
1 of 15
No
No
Drer\creb1a
1 of 15
No
No
Drer\crema
1 of 15
No
No
Drer\si:dkey-23i12.7
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\fos-1
4 of 15
Yes
Yes
Cele\crh-1
1 of 15
No
No
Cele\zip-11
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\ACA1
2 of 15
Yes
Yes
Scer\CST6
1 of 15
No
Yes
Scer\SKO1
1 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (4)
Spom\atf1
1 of 12
Yes
Yes
Spom\atf21
1 of 12
Yes
Yes
Spom\atf31
1 of 12
Yes
No
Spom\pcr1
1 of 12
Yes
Yes
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190DWW )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\kay
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00008484
Drosophila simulans
Dsim\GD21465
Drosophila sechellia
Dsec\GM12821
Drosophila erecta
Dere\GG11694
Drosophila yakuba
Dyak\GE23884
Drosophila ananassae
Dana\GF23375
Drosophila pseudoobscura pseudoobscura
Dpse\kay
Drosophila persimilis
Dper\GL23721
Drosophila willistoni
Dwil\GK11924
Drosophila virilis
Dvir\GJ10642
Drosophila mojavensis
Dmoj\GI10426
Drosophila grimshawi
Dgri\GH14331
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915094J )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17017282
Glossina morsitans
Tsetse fly
Gmor\GMOY007416
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_12587
Mayetiola destructor
Hessian fly
Mdes\Mdes000437
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL008953
Anopheles darlingi
American malaria mosquito
Adar\ADAC003940
Anopheles gambiae
Malaria mosquito
Agam\AGAP001093
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ003767
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0A2E )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA005140
Danaus plexippus
Monarch butterfly
Dple\DPOGS214573-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL009106
Apis florea
Little honeybee
Aflo\3001086004
Apis mellifera
Western honey bee
Amel\GB42049
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP10176
Bombus terrestris
Buff-tailed bumblebee
Bter\15216338
Linepithema humile
Argentine ant
Lhum\LH14843
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001d82
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012316
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_01933
Tribolium castaneum
Red flour beetle
Tcas\kay
Pediculus humanus
Human body louse
Phum\PHUM237480
Rhodnius prolixus
Kissing bug
Rpro\RPRC003541
Cimex lectularius
Bed bug
Clec\CLEC007924
Cimex lectularius
Bed bug
Clec\CLEC004474
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005814
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_02948
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X09Y7 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR004079
Strigamia maritima
European centipede
Smar\SMAR010745
Ixodes scapularis
Black-legged tick
Isca\ISCW010628
Stegodyphus mimosarum
African social velvet spider
Smim\KFM76881.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur21g00240
Tetranychus urticae
Two-spotted spider mite
Turt\tetur21g00200
Tetranychus urticae
Two-spotted spider mite
Turt\tetur21g00170
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g03610
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_302198
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0FN2 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Fos
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (3)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Atf-2
2 of 10
Atf3
2 of 10
CrebB
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 3 )
    Allele
    Disease
    Interaction
    References
    kayN-Ala.UAS
    ameliorates  cancer
    modeled by Ras85DV12.UAS, scrib1
    (Külshammer et al., 2015)
    kaypan-Ala.UAS
    ameliorates  cancer
    modeled by dlg1HMS01954
    (Bunker et al., 2015)
    kay3
    ameliorates  cancer
    modeled by Ras85DV12.UAS, scrib1
    (Külshammer et al., 2015)
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    FOS; Fos proto-oncogene, AP-1 transcription factor subunit
    5 of 15
    164810
        FOSL1; FOS like 1, AP-1 transcription factor subunit
        5 of 15
        136515
            FOSL2; FOS like 2, AP-1 transcription factor subunit
            5 of 15
            601575
                 
                FOSB; FosB proto-oncogene, AP-1 transcription factor subunit
                4 of 15
                164772
                    Functional Complementation Data
                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                    Interactions
                    Summary of Physical Interactions
                    esyN Network Diagram
                    Show neighbor-neighbor interactions:
                    Select Layout:
                    Legend:
                    Protein
                    RNA
                    Selected Interactor(s)
                    Interactions Browser
                    View in Interactions Browser
                    Please see the Physical Interaction reports below for full details
                    RNA-RNA
                    Physical Interaction
                    Assay
                    References
                    kay - mir-1
                    luminiscence technology, necessary binding region
                    (King et al., 2011)
                    RNA-protein
                    Physical Interaction
                    Assay
                    References
                    kay - piwi
                    anti tag coimmunoprecipitation, quantitative reverse transcription pcr
                    (Klein et al., 2016)
                    protein-protein
                    Physical Interaction
                    Assay
                    References
                    kay - Ada2b
                    anti tag coimmunoprecipitation, peptide massfingerprinting
                    (Weake et al., 2011)
                    kay - CG16813
                    fluorescent resonance energy transfer
                    (Reinke et al., 2013)
                    kay - CG16815
                    fluorescent resonance energy transfer
                    (Reinke et al., 2013)
                    kay - Cka
                    anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation
                    (Chen et al., 2002)
                    kay - HDAC1
                    pull down, autoradiography, anti tag coimmunoprecipitation, anti tag western blot, western blot
                    (Miotto et al., 2006)
                    kay - Jra
                    electrophoretic mobility shift assay, autoradiography, experimental knowledge based, fluorescent resonance energy transfer, two hybrid array
                    (Shokri et al., 2019, Reinke et al., 2013, Guruharsha et al., 2011, Perkins et al., 1990)
                    kay - REPTOR-BP
                    fluorescent resonance energy transfer
                    (Reinke et al., 2013)
                    kay - Ubx
                    bimolecular fluorescence complementation, fluorescence microscopy
                    (Bischof et al., 2018)
                    kay - abd-A
                    bimolecular fluorescence complementation, fluorescence microscopy
                    (Bischof et al., 2018)
                    kay - bsk
                    enzymatic study, autoradiography
                    (Ciapponi et al., 2001)
                    kay - chm
                    anti tag coimmunoprecipitation, western blot, pull down
                    (Miotto et al., 2006)
                    kay - gt
                    fluorescent resonance energy transfer
                    (Reinke et al., 2013)
                    kay - rl
                    enzymatic study, autoradiography
                    (Ciapponi et al., 2001)
                    kay - vri
                    anti tag coimmunoprecipitation, anti tag western blot
                    (Ling et al., 2012)
                    Summary of Genetic Interactions
                    esyN Network Diagram
                    esyN Network Key:
                    Suppression
                    Enhancement
                    View in Interactions Browser
                    Please look at the allele data for full details of the genetic interactions
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    kay
                    enhanceable
                    Atx2
                    (Sun et al., 2006)
                    kay
                    enhanceable
                    bsk
                    (Riesgo-Escovar and Hafen, 1997)
                    kay
                    enhanceable
                    CG32137
                    (Sun et al., 2006)
                    kay
                    enhanceable
                    Cka
                    (Chen et al., 2002)
                    kay
                    enhanceable
                    cnk
                    (Franciscovich et al., 2008)
                    Jra|kay
                    suppressible
                    cnk
                    (Franciscovich et al., 2008)
                    kay
                    enhanceable
                    Cnx99A
                    (Franciscovich et al., 2008)
                    kay
                    suppressible
                    Cnx99A
                    (Franciscovich et al., 2008)
                    Jra|kay
                    suppressible
                    CrebB
                    (Sanyal et al., 2002)
                    kay
                    suppressible
                    CRIF
                    (Lim et al., 2014)
                    kay
                    enhanceable
                    D1
                    (Sun et al., 2006)
                    Jra|kay
                    suppressible
                    dnc
                    (Sanyal et al., 2002)
                    Ras85D|kay|scrib
                    suppressible
                    Ets21C
                    (Külshammer et al., 2015)
                    kay
                    enhanceable
                    Fkbp14
                    (Franciscovich et al., 2008)
                    Jra|kay
                    suppressible
                    Fkbp14
                    (Franciscovich et al., 2008)
                    kay
                    enhanceable
                    jigr1
                    (Sun et al., 2006)
                    kay
                    enhanceable
                    jing
                    (Sun et al., 2006)
                    kay
                    suppressible
                    Jra::kay
                    (Ciapponi and Bohmann, 2002)
                    kay
                    enhanceable
                    Jra
                    (Franciscovich et al., 2008, Riesgo-Escovar and Hafen, 1997)
                    kay
                    suppressible
                    Jra
                    (Franciscovich et al., 2008)
                    kay
                    suppressible
                    lbm
                    (Franciscovich et al., 2008)
                    kay
                    suppressible
                    Mbs
                    (Franciscovich et al., 2008)
                    kay
                    enhanceable
                    Mnn1
                    (Cerrato et al., 2006)
                    kay
                    enhanceable
                    Pde8
                    (Franciscovich et al., 2008)
                    Jra|kay
                    suppressible
                    Pde8
                    (Franciscovich et al., 2008)
                    kay
                    enhanceable
                    pigeon
                    (Franciscovich et al., 2008)
                    kay
                    suppressible
                    pigeon
                    (Franciscovich et al., 2008)
                    kay
                    suppressible
                    puc
                    (Ramet et al., 2002, Zeitlinger and Bohmann, 1999)
                    kay
                    suppressible
                    Pvf1
                    (Franciscovich et al., 2008)
                    kay
                    enhanceable
                    Sdc
                    (Franciscovich et al., 2008)
                    Jra|kay
                    suppressible
                    Sdc
                    (Franciscovich et al., 2008)
                    kay
                    enhanceable
                    Sema2a
                    (Franciscovich et al., 2008)
                    Jra|kay
                    suppressible
                    sgg
                    (Franciscovich et al., 2008)
                    kay
                    enhanceable
                    sgg
                    (Franciscovich et al., 2008)
                    kay
                    suppressible
                    spag
                    (Franciscovich et al., 2008)
                    kay
                    suppressible
                    sty
                    (Franciscovich et al., 2008)
                    kay
                    enhanceable
                    sty
                    (Franciscovich et al., 2008)
                    kay
                    suppressible
                    svp
                    (Gritzan et al., 2002)
                    kay
                    enhanceable
                    XNP
                    (Sun et al., 2006)
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    Atf3
                    suppressible
                    kay
                    (Sekyrova et al., 2010)
                    bsk
                    enhanceable
                    kay
                    (Rallis et al., 2010)
                    chm
                    enhanceable
                    kay
                    (Miotto et al., 2006)
                    dsh
                    suppressible
                    kay
                    (Weber et al., 2008)
                    Egfr
                    suppressible
                    kay
                    (Ciapponi et al., 2001)
                    Ets21C|Ras85D|scrib
                    suppressible
                    kay
                    (Külshammer et al., 2015)
                    fz
                    suppressible
                    kay
                    (Ciapponi et al., 2001)
                    H
                    enhanceable
                    kay
                    (Müller et al., 2005)
                    hep
                    suppressible
                    kay
                    (Meng and Biteau, 2015, Miotto et al., 2006)
                    hop
                    suppressible
                    kay
                    (Tokusumi et al., 2009)
                    Jra
                    enhanceable
                    kay
                    (Franciscovich et al., 2008)
                    knrl
                    enhanceable
                    kay
                    (Gritzan et al., 2002)
                    Mnn1
                    enhanceable
                    kay
                    (Cerrato et al., 2006)
                    Ppt1
                    suppressible
                    kay
                    (Buff et al., 2007)
                    Pvr|hep
                    suppressible
                    kay
                    (Mathieu et al., 2007)
                    Rab8
                    suppressible
                    kay
                    (West et al., 2015)
                    Rala
                    suppressible
                    kay
                    (Balakireva et al., 2006)
                    Ras85D
                    suppressible
                    kay
                    (Meng and Biteau, 2015, Freeman et al., 2010)
                    Ras85D|scrib
                    suppressible
                    kay
                    (Katheder et al., 2017, Külshammer et al., 2015)
                    Ras85D|scrib
                    suppressible
                    Ets21C|kay
                    (Katheder et al., 2017)
                    rl
                    enhanceable
                    kay
                    (Ciapponi et al., 2001)
                    rl
                    suppressible
                    kay
                    (Gritzan et al., 2002, Ciapponi et al., 2001)
                    scrib
                    enhanceable
                    kay
                    (Uhlirova and Bohmann, 2006)
                    sd
                    suppressible
                    kay
                    (Miotto et al., 2006)
                    SERCA|comt
                    suppressible
                    kay
                    (Freeman et al., 2010)
                    sev
                    suppressible
                    kay
                    (Ciapponi et al., 2001)
                    sgg
                    suppressible
                    Jra|kay
                    (Franciscovich et al., 2008)
                    sgg
                    enhanceable
                    kay
                    (Franciscovich et al., 2008)
                    sgg
                    suppressible
                    kay
                    (Franciscovich et al., 2008)
                    shot
                    suppressible
                    kay
                    (Valakh et al., 2013)
                    SkpA
                    suppressible
                    kay
                    (Brace et al., 2014)
                    slpr
                    enhanceable
                    kay
                    (Polaski et al., 2006)
                    Sox21a
                    suppressible
                    kay
                    (Meng and Biteau, 2015, Zhai et al., 2015)
                    wnd
                    suppressible
                    kay
                    (Collins et al., 2006)
                    External Data
                    Subunit Structure (UniProtKB)
                    Homodimer. Heterodimer with Jra. The kay-Jra heterodimer binds more stably to the AP-1 site than either of the two proteins alone.
                    (UniProt, P21525, A8MPH9 )
                    Linkouts
                    BioGRID - A database of protein and genetic interactions.
                    DroID - A comprehensive database of gene and protein interactions.
                    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                    MIST (genetic) - An integrated Molecular Interaction Database
                    MIST (protein-protein) - An integrated Molecular Interaction Database
                    Pathways
                    Genomic Location and Detailed Mapping Data
                    Chromosome (arm)
                    3R
                    Recombination map
                    3-99
                    Cytogenetic map
                    99B10-99C1
                    Sequence location
                    3R:29,765,995..29,794,113 [+]
                    FlyBase Computed Cytological Location
                    Cytogenetic map
                    Evidence for location
                    99B10-99C1
                    Limits computationally determined from genome sequence between P{PZ}l(3)0674306743 and P{PZ}ncd05884
                    Experimentally Determined Cytological Location
                    Cytogenetic map
                    Notes
                    References
                    99B7-99B11
                    (determined by in situ hybridisation)
                    (Dequier et al., 2001)
                    99B9-99B10
                    (determined by in situ hybridisation)
                    (Perkins et al., 1990)
                    Experimentally Determined Recombination Data
                    Location
                    3-99
                    (FlyBase, 2016, Tearle and Nusslein-Volhard, 1987)
                    3-96.9
                    (Comeron et al., 2012)
                    Left of (cM)
                    Right of (cM)
                    Notes
                    Stocks and Reagents
                    Stocks (34)
                    Genomic Clones (31)
                    cDNA Clones (130)
                     

                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                    cDNA clones, fully sequences
                    BDGP DGC clones
                    Other clones
                    Drosophila Genomics Resource Center cDNA clones

                    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                    cDNA Clones, End Sequenced (ESTs)
                    BDGP DGC clones
                    Other clones
                    RNAi and Array Information
                    Linkouts
                    DRSC - Results frm RNAi screens
                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                    Antibody Information
                    Laboratory Generated Antibodies
                     
                    polyclonal
                    (Ling et al., 2012, Hartwig et al., 2008)
                    Commercially Available Antibodies
                     
                    Other Information
                    Relationship to Other Genes
                    Source for database identify of
                    Source for database merge of
                    Source for merge of: kay CG15507
                    (Hudson and Goldstein, 2005)
                    Additional comments
                    The sro (shroud) complementation group is not allelic to the kay gene (as stated in FBrf0157169) but instead corresponds to the CG12068 annotation; the sro1 and sroO4-105 alleles each have a nonsense mutation that disrupts the catalytic centre of the predicted CG12068 protein, the P{}sroP54 insertion which is inserted in the region upstream of kay causes a large reduction in the CG12068 transcript level as well as affecting kay and the lethality of the sro1 allele is rescued by overexpression of CG12068.
                    (Niwa et al., 2010)
                    Annotations CG15507 and CG15509 merged as CG33956 (which corresponds to kay) in release 4.2 of the genome annotation.
                    (FlyBase Genome Annotators, 2005)
                    FlyBase curator comment: The sro (shroud) complementation group is not allelic to the kay gene (as stated in FBrf0157169) but instead corresponds to the CG12068 annotation (see FBrf0210924).
                    (Giesen et al., 2003)
                    Other Comments
                    The kay α isoform acts as a transcriptional regulator of circadian rhythms. It appears to modulate both circadian feedback loops, with results suggesting it acts as a repressor of the Clk/cyc transactivation complex and as an inhibitor of vri-mediated repression. The kay α protein binds directly to the vri protein.
                    (Ling et al., 2012)
                    The kay protein binds specifically to the promoter region of CycB.
                    (Hyun et al., 2006)
                    RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a specific decrease in AttA activity in response to heat-killed E.coli when assayed in S2 cells.
                    (Kleino et al., 2005)
                    RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
                    (Boutros et al., 2004)
                    kay is required for wound healing.
                    (Ramet et al., 2002)
                    kay is necessary for the proper posteriorward migration of the main body follicle cells during stage 9 of oogenesis. It also controls, from stage 11 onwards, the morphogenetic reorganisation of the follicle cells that are committed to secrete the dorsal appendages.
                    (Dequier et al., 2001)
                    kay function is required for its own upregulation.
                    (Szuts and Bienz, 2000)
                    kay is required for thorax closure during metamorphosis.
                    (Zeitlinger and Bohmann, 1999)
                    In vitro protein binding assays demonstrate kay is a poor candidate for a transcriptional activator acting through the Ubx cAMP response element (CRE).
                    (Eresh et al., 1997)
                    dpp, by inducing kay, broadly defines an endodermal region which thus becomes predisposed to express lab. kay cooperates with signal-activated response factors to confer the precise pattern of lab expression in the endoderm.
                    (Riese et al., 1997)
                    Mutations in kay are described.
                    (Riesgo-Escovar and Hafen, 1997)
                    kay is required for dorsal closure and elongation of cells in the lateral epidermis during embryogenesis.
                    (Zeitlinger et al., 1997)
                    The DebA upstream region contains a binding site for the Jra/kay (AP-1) protein complex, which negatively regulates its transcription.
                    (Goldstein, 1995)
                    The AP-1 complex encodes two proteins that have functional and structural properties in common with mammalian Fos and Jun proto-oncogene products; kay and Jra, respectively. The biochemical properties of the kay gene product have been examined in vitro and the expression pattern in developing embryos studied.
                    (Perkins et al., 1990)
                    kay lies within 12kb of ca.
                    (Perkins et al., 1990)
                    kay is a developmentally regulated transcription factor and its potential interplay with Jra may play an important role in cell-type specific transcription during embryonic development.
                    (Perkins et al., 1990)
                    Origin and Etymology
                    Discoverer
                    Etymology
                    Identification
                    External Crossreferences and Linkouts ( 90 )
                    Sequence Crossreferences
                    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                    Other crossreferences
                    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                    Flygut - An atlas of the Drosophila adult midgut
                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                    InterPro - A database of protein families, domains and functional sites
                    KEGG Genes - Molecular building blocks of life in the genomic space.
                    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                    modMine - A data warehouse for the modENCODE project
                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                    Linkouts
                    BioGRID - A database of protein and genetic interactions.
                    DPiM - Drosophila Protein interaction map
                    DroID - A comprehensive database of gene and protein interactions.
                    DRSC - Results frm RNAi screens
                    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                    FlyMine - An integrated database for Drosophila genomics
                    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                    MIST (genetic) - An integrated Molecular Interaction Database
                    MIST (protein-protein) - An integrated Molecular Interaction Database
                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                    Synonyms and Secondary IDs (39)
                    Reported As
                    Symbol Synonym
                    AP-1
                    (Harris et al., 2016, Casas-Tinto et al., 2008, Casas-Tinto et al., 2008, Franciscovich et al., 2008, Juarez et al., 2007, Wang et al., 2007, Bhaskara et al., 2006, Monroe et al., 2006, Etter et al., 2005, Harden, 2005, Jindra et al., 2005, Short et al., 2005, Zhang et al., 2002, Zeitlinger et al., 1997, Mlodzik et al., 1993)
                    AP1
                    (Mrinal and Nagaraju, 2010, Moussian and Uv, 2005, Cerrato et al., 2004, Sanyal et al., 2003, Sanyal et al., 2003)
                    CG15507
                    (Hudson and Goldstein, 2008, Sun et al., 2006, Müller et al., 2005, Giesen et al., 2003)
                    CG15509
                    (Hudson and Goldstein, 2005, Kleino et al., 2005, Kim et al., 2004)
                    CG33956
                    (Reinke et al., 2013, Schertel et al., 2013, Hadar et al., 2012, Ni et al., 2010.12.1, Perkins et al., 2009, Ni et al., 2008)
                    D-Fos
                    (Houtz et al., 2017, Llense and Martín-Blanco, 2008, Balakireva et al., 2006, Jindra et al., 2004, Ciapponi and Bohmann, 2002, Ciapponi and Bohmann, 2002, Dobens and Raftery, 2001, Blau and Young, 1999, Zeitlinger and Bohmann, 1999, Zeitlinger et al., 1998, Bienz, 1997, Eresh et al., 1997, Riese et al., 1997)
                    D-fos
                    (Lee et al., 2008, Casas-Tinto et al., 2007, Salgado and Riesgo-Escovar, 2004, Kockel et al., 2001, Zeitlinger et al., 1997, Dickson, 1995)
                    D-fos/kay
                    (Friedman and Perrimon, 2006)
                    DFOS
                    (Xia and Karin, 2004, Chen et al., 2003, Chen et al., 2002, Reed et al., 2001, Chen et al., 2000, Anonymous, 1998)
                    DFos
                    (Tsai et al., 2018, Lim et al., 2014, Brock et al., 2012, Grima et al., 2008, Luo et al., 2007, Guichard et al., 2006, Miotto et al., 2006, Brennan and Anderson, 2004, Varfolomeev and Ashkenazi, 2004, Hoeffer et al., 2003, Pena-Rangel et al., 2002, Dequier et al., 2001, Dobens et al., 2001, Gibson and Schubiger, 2001, Dequier et al., 1999, Ip and Davis, 1998, Riesgo-Escovar and Hafen, 1997)
                    DFra
                    (Riesgo-Escovar and Hafen, 1997)
                    DM3
                    (Reinke et al., 2013)
                    DM30
                    (Reinke et al., 2013)
                    Dfos
                    (Weber et al., 2012, Casas-Tinto et al., 2008, Casas-Tinto et al., 2008, Lee et al., 2008, Lee et al., 2007, Nazario-Yepiz and Riesgo-Escovar, 2007, Bosch et al., 2005, Bosch et al., 2005, Woolner et al., 2005, Chen et al., 2002, Lehmann et al., 2002, Nichols et al., 2002, Van Aelst and Symons, 2002, Nedelcheva et al., 2001, Rousseau and Goldstein, 2001, Rousseau et al., 2001, Suzanne et al., 2001, Dequier et al., 2000, Szuts and Bienz, 2000, Agnes and Noselli, 1999, Noselli and Agnes, 1999, Goberdhan and Wilson, 1998, Noselli et al., 1998)
                    FOS
                    (Pasco et al., 2015, Gao et al., 2014, Ferrandon, 2013, Jemc et al., 2012)
                    Fos
                    (Rojas-Ríos and Simonelig, 2018, Stuelten et al., 2018, Borgen et al., 2017, Hao and Collins, 2017, Jordán-Álvarez et al., 2017, Grill et al., 2016, Liu et al., 2015, Meng and Biteau, 2015, West et al., 2015, Wu et al., 2015, Ayyaz and Jasper, 2013, Dekanty and Milán, 2013, Klinedinst et al., 2013, Nechipurenko and Broihier, 2012, Wang and Jin, 2011, Boyle et al., 2010, Lee et al., 2010, Rallis et al., 2010, Xiong et al., 2010, Kim et al., 2009, Hartwig et al., 2008, Wu et al., 2008, Juarez et al., 2007, Luo et al., 2006, Etter et al., 2005, Mace et al., 2005, Miotto et al., 2004, Sanyal et al., 2003, Sanyal et al., 2003, Tran and Berg, 2003, Jacinto et al., 2002, Kaltschmidt et al., 2002, Mlodzik, 2002, Schaeffer et al., 2002, Jacinto et al., 2001, Settleman, 2001, Zeitlinger et al., 1997, Bohmann et al., 1994, Mlodzik et al., 1993)
                    Fra
                    (Anonymous, 1998)
                    KAY
                    (Fukuyama et al., 2013)
                    Kay
                    (Bischof et al., 2018, Kwon et al., 2018, Richardson and Portela, 2018, Koch et al., 2017, Atkins et al., 2016, Lee et al., 2016, Merkling et al., 2015, Macdonald et al., 2013, Ríos-Barrera and Riesgo-Escovar, 2013, Herranz et al., 2010, Stielow et al., 2008)
                    c-Fos
                    (Vaqué et al., 2013, Muralikrishna and Parnaik, 2001)
                    c-fos
                    (Billmann et al., 2018, Miyashita et al., 2018, Domingues and Ryoo, 2008)
                    d-Fos
                    (Zhu et al., 2019)
                    d-fos
                    (Jindra et al., 2003)
                    dAP-1
                    (Freeman, 2015, Wang and Goldstein, 1993)
                    dFRA
                    (Davis et al., 2008, Taylor, 2000, Bonneton and Wegnez, 1995, Briata et al., 1993, Perkins et al., 1988)
                    dFos
                    (Zhang et al., 2019, Bond and Foley, 2009, Tokusumi et al., 2009, Franciscovich et al., 2008, Buff et al., 2007, Waltzer and Bienz, 1998)
                    dFra
                    (Bausenwein et al., 1993, Perkins et al., 1990)
                    dfos
                    (Wu et al., 2008)
                    dlhD
                    fbz
                    (Etter et al., 2005)
                    fos
                    (Bushnell et al., 2018, Li et al., 2017, Chen et al., 2016, Losick et al., 2016, Willsey et al., 2016, Bunker et al., 2015, Chen et al., 2015, Külshammer et al., 2015, Brace et al., 2014, Stone et al., 2014, Valakh et al., 2013, Vonhoff et al., 2013, Wang et al., 2013, Mozer and Sandstrom, 2012, Nechipurenko and Broihier, 2012, Milton et al., 2011, Sekyrova et al., 2010, Massaro et al., 2009, Pearson et al., 2009, Davis et al., 2008, Franciscovich et al., 2008, Haussmann et al., 2008, Pierre et al., 2008, Mathieu et al., 2007, Cerrato et al., 2006, Hyun et al., 2006, Uhlirova and Bohmann, 2006, Cerrato et al., 2004, Riesgo-Escovar et al., 2004, Ciapponi and Bohmann, 2002, Sanyal et al., 2002, Rousseau, 2001.1.2, Rousseau, 2001.1.2, Rousseau, 2001.1.2, Rousseau, 2001.1.2, Nairz and Hafen, 1999)
                    fra
                    (Mrinal and Nagaraju, 2010, Davis et al., 2008)
                    kay
                    (Adhikari et al., 2019, Chai et al., 2019, Chang et al., 2019, Ho et al., 2019, Meltzer et al., 2019, Shokri et al., 2019, Behrman et al., 2018, Bischof et al., 2018, Bushnell et al., 2018, Hall et al., 2018, Lavoy et al., 2018, Mecklenburg et al., 2018, Mondal et al., 2018, Tsai et al., 2018, Katheder et al., 2017, Revaitis et al., 2017, Tian et al., 2017, Tokusumi et al., 2017, Transgenic RNAi Project members, 2017-, Zhou et al., 2017, Aggarwal et al., 2016, Carbone et al., 2016, Voelzmann et al., 2016, Willsey et al., 2016, Bornstein et al., 2015, Dembeck et al., 2015, Gene Disruption Project members, 2015-, Mosher et al., 2015, Nagarkar-Jaiswal et al., 2015, Schertel et al., 2015, Vedanayagam and Garrigan, 2015, Zhai et al., 2015, Faisal et al., 2014, Gonzalez et al., 2014, Guo et al., 2014, Bonke et al., 2013, Carter, 2013, Iyer et al., 2013, Külshammer and Uhlirova, 2013, Kwon et al., 2013, Saunders et al., 2013, Schertel et al., 2013, Telonis-Scott et al., 2013, Vaque et al., 2013, Wang et al., 2013, Hadar et al., 2012, Hainaut et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Ling et al., 2012, Spokony and White, 2012.5.22, Weber et al., 2012, Abruzzi et al., 2011, Biteau and Jasper, 2011, Friedman et al., 2011, Weake et al., 2011, Zhang and Arnosti, 2011, Niwa et al., 2010, Dubruille et al., 2009, Massaro et al., 2009, Tokusumi et al., 2009, Grima et al., 2008, Hudson and Goldstein, 2008, Stofanko et al., 2008, Weber et al., 2008, Zhao et al., 2008, Zhou et al., 2008, Buszczak et al., 2007, Hudson et al., 2007, Hudson et al., 2007, Luo et al., 2007, Neuman-Silberberg, 2007, Valanne et al., 2007, Zeitlinger et al., 2007, Cerrato et al., 2006, Polaski et al., 2006, Zhang et al., 2006, Kim et al., 2005, Mace et al., 2005, Mace et al., 2005, Giesen et al., 2003, Souid and Yanicostas, 2003, Lehmann et al., 2002, Jurgens et al., 1984)
                    kayak
                    (Aggarwal et al., 2017, Houtz et al., 2017, Purice et al., 2017)
                    Name Synonyms
                    Dfos/kayak
                    (Souid and Yanicostas, 2003)
                    Fos
                    (Katsuyama and Paro, 2011, Collins et al., 2006)
                    Fos-related antigen
                    (Mrinal and Nagaraju, 2010)
                    Kayak
                    (Miyashita et al., 2018, Atkins et al., 2016, Castillo et al., 2015, Freeman, 2015, Fukuyama et al., 2013, Macdonald et al., 2013, Lu et al., 2012, Monnier et al., 2012, Razzell et al., 2011, Buff et al., 2007)
                    activator protein 1
                    (Bhaskara et al., 2006)
                    dorsal holes D
                    kayak
                    (Ho et al., 2019, Lu et al., 2017, Ray et al., 2017, Tokusumi et al., 2017, Aggarwal et al., 2016, Lee et al., 2016, Meehan et al., 2016, Wieschaus and Nüsslein-Volhard, 2016, Lehner, 2015.6.19, Vedanayagam and Garrigan, 2015, Faisal et al., 2014, Freeman et al., 2013, Iyer et al., 2013, Hainaut et al., 2012, Monnier et al., 2012, Weber et al., 2012, King et al., 2011, Boyle et al., 2010, Magwire et al., 2010, Mourikis et al., 2010, Niwa et al., 2010, Massaro et al., 2009, Grima et al., 2008, Hartwig et al., 2008, Hudson and Goldstein, 2008, Park and Song, 2008, Pierre et al., 2008, Stofanko et al., 2008, Zhao et al., 2008, Hudson et al., 2007, Hudson et al., 2007, Luo et al., 2007, Neuman-Silberberg, 2007, Burnette et al., 2005, Giesen et al., 2003, Bellotto et al., 2002, Jurgens et al., 1984)
                    Secondary FlyBase IDs
                    • FBgn0053956
                    • FBgn0000468
                    • FBgn0000725
                    • FBgn0003506
                    • FBgn0039693
                    • FBtr0085478
                    • FBpp0084844
                    • FBtr0085479
                    • FBpp0084845
                    • FBtr0085480
                    • FBpp0084846
                    Datasets (0)
                    Study focus (0)
                    Experimental Role
                    Project
                    Project Type
                    Title
                    References (387)