HomeGene Dmel\kay
| General Information | ||||
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| Symbol | Dmel\kay | Species | D. melanogaster | |
| Name | kayak | Annotation symbol | CG33956 | |
| Feature type | protein_coding_gene | FlyBase ID | FBgn0001297 | |
| Created / Updated | 2005-08-10/2005-08-10 | |||
| Genomic Location | ||||
| Chromosome (arm) | 3R | Recombination map | 3-100 | |
| Cytogenetic map | 99B10-99C1 | Sequence location | 3R:25,592,707..25,619,838 [+] | |
| Map ( GBrowse ) | 
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Summary Information
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Automatically generated summary
See sections below for more information | The gene kayak is referred to in FlyBase by the symbol kay (CG33956, FBgn0001297). It has the cytological map location 99B10-99C1. Its sequence location is 3R:25592707..25619838. Its molecular function is described as: sequence-specific DNA binding; DNA binding; RNA polymerase II transcription factor activity; transcription factor activity; transcription factor binding; protein binding; specific RNA polymerase II transcription factor activity; protein heterodimerization activity; protein dimerization activity. It is involved in the biological processes described with 18 unique terms, many of which group under: anatomical structure development; cell motility; sensory organ development; response to stress; cell cycle; ovarian follicle cell development; embryonic development via the syncytial blastoderm; establishment of planar polarity; response to external stimulus; regulation of cyclin-dependent protein kinase activity; immune response; organ development; JNK cascade; regulation of metabolic process; wound healing. 40 alleles are reported. The phenotypes of these alleles are annotated with 49 unique terms, many of which group under: organ system; adult segment; nervous system; adult mesothoracic segment; embryonic nervous system; peripheral nervous system; thoracic segment; adult; anatomical structure; portion of tissue. It has 4 annotated transcripts and 4 annotated polypeptides. | |||
| External Summaries | ||||
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Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
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| Gene/Allele symbols may differ from current usage | kay: kayak
Homozygous lethal; embryo open dorsally.
sro: shroud
Embryonic lethal. No differentiation of cuticle and
mouthparts.
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Detailed Mapping Data
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| FlyBase Computed Cytological Location | ||||
Cytogenetic map Evidence for location 99B10-99C1
Limits computationally determined from genome sequence between P{PZ}l(3)0674306743 and P{PZ}ncd05884
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| Experimentally Determined Cytological Location | ||||
Cytogenetic map Notes References 99B7-99B11 (determined by in situ hybridisation)
99B9-99B10 (determined by in situ hybridisation)
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| Experimentally Determined Recombination Data | ||||
| Location | 3-100 3-99--100 | |||
| Left of (cM) | ||||
| Right of (cM) | ||||
| Notes | ||||
| Molecular Map Data | ||||
Gene Order (in direction of increasing cytology)
References Gene Order (overall orientation not stated) References Overall orientation not stated: kay? fig? kay? | ||||
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Gene Model & Products
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Please see the
GBrowse view of
Dmel\kay
for information on other features
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| Comments on Gene Model | ||||
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Transcript Data
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| Annotated Transcripts | ||||
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) FBtr0099989
3501
595 FBtr0099990
3195
546 FBtr0099988
3261
722 FBtr0290076
3360
755 | ||||
| Additional Transcript Data & Comments | ||||
| Reported size (kB) | 3.65 (northern blot) | |||
| Comments | ||||
| External Data | ||||
| Crossreferences | ||||
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Polypeptide Data
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| Annotated Polypeptides | ||||
Name FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
FBpp0084844
62.8
595
5.62
FBpp0084846
57.5
546
6.32
FBpp0099941
78.3
722
7.22
FBpp0288515
80.6
755
6.77
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| Additional Polypeptide Data & Comments | ||||
| Reported size (kD) | 595 (aa); 70 (kD observed) | |||
| Comments | ||||
| External Data | ||||
| Linkouts | PANTHER
- Protein classification by function, families, and pathways
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| Crossreferences | InterPro
domains - A database of protein families, domains, and functional sites
• Fos transforming protein (IPR000837)
Basic-leucine zipper (bZIP) transcription factor (IPR004827)
bZIP transcription factor, bZIP-1 (IPR011616)
TRANSFAC
- Eukaryotic transcription factors, their genomic binding sites, and DNA-binding profiles
•
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Sequences Consistent with the Gene Model
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| DDBJ
/
EMBL / GenBank | DNA sequence Protein sequence Name | |||
| UniProtKB/Swiss-Prot | ||||
| UniProtKB/TrEMBL | ||||
| Maps to | ||||
| Does NOT map to | ||||
| Identified with | ||||
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Mapped Features & Mutations
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Please see
GBrowse
or insertion reports for information on insertions of transgenic
constructs and features not listed here
Type Symbol & Location Additional Notes References point mutation reported_na_change=T1045A reported_pr_change=L92@ comment=The presence of a nonsense mutation in kay[1] is disputed by the authors of FBrf0100315 and FBrf10112258 who find that kay[1] is caused by a deletion that breaks after the first exon and removes exon 1. evidence=experimental pr_change=L92@ na_change=T25617167A | ||||
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External Data
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| Linkouts | DEDB
- Drosophila exon database: splicing graphs
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| Crossreferences | ||||
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Expression Data
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| FlyBase-Curated Data | ||||
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Transcript and Protein data | Please see the FlyBase Gene Expression Report for details of gene expression from the literature. | |||
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Summary of Transcript Expression
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Stage Tissue/Position
Reference
embryonic stage | stage 15
eo neuron
embryonic stage
dorsal ectoderm
embryonic stage | stage 15
embryonic/larval midgut
embryonic stage | stage 15
muscle attachment site
embryonic stage
amnioserosa
embryonic stage | stage 15
embryonic/larval hindgut
embryonic stage | stage 15
anal pad
embryonic stage | stage 15
multidendritic neuron
embryonic stage
embryonic stage | stage 15
embryonic peripheral nervous system | restricted
embryonic stage | 4-8 hr
head | restricted | ||||
| Marker for | ||||
| Subcellular Localization | ||||
| CV Term | ||||
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Summary of Polypeptide Expression
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Stage Tissue/Position
Reference
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| Marker for | ||||
| Subcellular Localization | ||||
| CV Term | ||||
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Microarray Data
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Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002) 
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External Data & Images
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| Linkouts | FLIGHT
- Cell culture data for RNAi and other high-throughput technologies
FlyAtlas
- Adult expression by tissue, using Affymetrix Dros2 array
GEO (NCBI)
- Gene expression data: microarray and other high-throughput technologies
FlyExpress
- Embryonic expression images (BDGP data)
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Alleles & Phenotypes
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Summary of Allele Phenotypes
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Lethality Allele Other Phenotypes Allele | ||||
Stage(s)
4-6
Stage(s)
7-8
Stage(s)
9-10
Stage(s)
11-12
Stage(s)
13-16