• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\kay

General Information
Symbol	Dmel\kay	Species	D. melanogaster
Name	kayak	Annotation symbol	CG33956
Feature type	protein_coding_gene	FlyBase ID	FBgn0001297
Gene Model Status	Current	Stock availability	21 publicly available
Also Known As	DFos, fos, D-fos, AP-1, dFRA, AP1, CG15507, CG15509, c-Fos, Fra
Genomic Location
Chromosome (arm)	3R	Recombination map	3-99
Cytogenetic map	99B10-99C1	Sequence location	3R:25,592,497..25,619,838 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene kayak is referred to in FlyBase by the symbol Dmel\kay (CG33956, FBgn0001297). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; sequence-specific DNA binding; sequence-specific DNA binding RNA polymerase II transcription factor activity; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; protein heterodimerization activity; DNA binding. There is experimental evidence for 15 unique biological process terms, many of which group under: anatomical structure development; cellular process involved in reproduction; sensory organ development; cellular component organization or biogenesis; biological regulation; cell cycle; multicellular organismal reproductive process; immune response; growth; wound healing. 46 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; adult segment; organ system; adult mesothoracic segment; external compound sense organ; synapse; axon; non-connected developing system; imaginal precursor; nervous system. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Basic-leucine zipper (bZIP) transcription factor; Fos transforming protein; bZIP transcription factor, bZIP-1. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 12-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult crop, larval hindgut, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, larval/adult midgut, adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, adult carcass. Gene sequence location is 3R:25592497..25619838.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	kay: kayak Homozygous lethal; embryo open dorsally. sro: shroud Embryonic lethal. No differentiation of cuticle and mouthparts.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	References Magwire et al., 2010, PLoS Genet. 6(7): e1001037 Sequence features BKN32849 HFA13962 HFA16977 HFA15048 Controlled Vocabulary Terms larval stage embryonic stage 8 posterior ubiquitous embryonic stage 4 oogenesis stage S10B ventral ectoderm positive regulation of transcription from RNA polymerase II promoter motor neuron amnioserosa anlage organism polar follicle cell cephalic furrow RP2 neuron embryonic leading edge cell adult stage embryonic stage 2 embryonic stage 5 midgut constriction 1 embryonic cycle 6 embryonic stage 1 oogenesis stage S6 embryonic cycle 4 precursor embryonic stage 16 oogenesis stage S10A oogenesis stage S8 sequence-specific DNA binding RNA polymerase II transcription factor activity RP5 neuron posterior transverse furrow aCC neuron subset RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription RP3 neuron ovary embryonic stage 6 centripetally migrating follicle cell embryonic cycle 3 nurse cell prepupal stage P4(i) late extended germ band stage oogenesis stage S10 stomodeal invagination oogenesis stage S9 oogenesis stage S13 oogenesis stage S7 border follicle cell embryonic/larval salivary gland epithelium embryonic stage 13 anterior female embryonic stage 7 oogenesis stage S5 faint transcription factor complex intense embryonic stage 3 embryonic cycle 5 embryonic cycle 8 embryonic cycle 7 embryonic stage 14 male oogenesis stage S12
FB2011_10	References Herranz et al., 2010, Mol. Ecol. 19(19): 4255--4264
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 99B10-99C1   Limits computationally determined from genome sequence between P{PZ}l(3)0674306743 and P{PZ}ncd05884
Experimentally Determined Cytological Location
Cytogenetic map Notes References 99B7-99B11   (determined by in situ hybridisation)   (Dequier et al., 2001) 99B9-99B10   (determined by in situ hybridisation)   (Perkins et al., 1990)
Experimentally Determined Recombination Data
Location	3-99 (Tearle and Nusslein-Volhard, 1987)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\kay for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.39
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) kay-RA FBtr0099989  NM_001032407   3586   595 kay-RB FBtr0099990  NM_001032406   3195   546 kay-RD FBtr0099988  NM_001032408   3471   722 kay-RF FBtr0290076  NM_001032405   4577   755
Additional Transcript Data & Comments
Reported size (kB)	3.65 (northern blot) (Perkins et al., 1990)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein kay-PA   FBpp0084844   62.8   595   5.62     NP_001027579   AAZ83992 kay-PB   FBpp0084846   57.5   546   6.32     NP_001027578   AAZ83993 kay-PD   FBpp0099941   78.3   722   7.22     NP_001027580   AAZ83991 kay-PF   FBpp0288515   80.6   755   6.77     NP_001027577   AAZ83994
Additional Polypeptide Data & Comments
Reported size (kDa)	595 (aa); 70 (kD observed) (Perkins et al., 1990)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Fos transforming protein (IPR000837) Basic-leucine zipper (bZIP) transcription factor (IPR004827) bZIP transcription factor, bZIP-1 (IPR011616)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA438883   AA568005   AE014297 AAZ83991   AE014297 AAZ83992   AE014297 AAZ83993   AE014297 AAZ83994   AC007892   AF238310 AAF69496   AF332657   AF332658   AF332659 AAK11268   AF332660 AAK11267   AI296315   AI387267   AI531808   AI532231   AI532315   AI532844   AI532983   AI541617   AI541842   AI544419   AI546542   AW944364   AY069805 AAL39950   AY574373 AAS87366   BF495797   BG636385   BG636811   BG638036   BI142077   BI167167   BI231374   BI366179   BI567275   BI579661   BI588033   BI624393   BI626016   BI628181   BI633437   BI633643   BI638263   BI638556   BI640382   BI641059   BI641779   BP544604   BP544605   BP547008   BP547345   BP552609   BP552610   BP559912   BP559913   BP559920   BP559921   BT088433   BT099528   BZ665498   BZ665561   CA807520   CK657147   CK662422   CL528091   CL943540   CO154478   CO154680   CO154891   CO154984   CO155658   CO156442   CO156503   CO156651   CO157004   CO157099   CO179716   CO188880   CO196197   CO262147   CO269945   CO270953   CO271688   CO285288   CO285578   CO287821   CO288031   CO288668   CO297611   CO302453   CO304158   CO304232   CO304896   CO306058   CO312930   CO315704   CO319872   CO320372   CO326235   CO326914   CO333380   CO333933   CO336770   CO336963   CO337036   CO337041   CO337450   CO345054   CZ472839   CZ480858   CZ484500   EC059701   EC061213   EC065110   EC067189   EC068215   EC074806   EC078572   EC087987   EC088215   EC194425   EC203512   EC207565   EC208780   EC225561   EC228308   EC230637   EC234729   EC237095   EC237747   EC244378   EC249738   EC255191   EC261124   EC261557   EC262432   EC263067   EC263769   EC263823   EC265858   EC266062   EC266683   EC267607   EC267702   EC267846   EC267874   ES688742   ES693761   EV584085   GH784053   GH787069   GH791296   GH794051   GH802833   GH807336   GH827808   GH841305   GH845262   GH852583   GH855547   GH859135   GH871296   GH913269   GH917507   GH918629   GH923239   GH926294   GH933534   GH940126   GH940498   X54143 CAA38082
UniProtKB/Swiss-Prot	P21525 A8MPH9
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism | ubiquitous & uniform   (Souid and Yanicostas, 2003) Comment:kay-RA embryonic stage 4 -- 7   amnioserosa anlage   (Souid and Yanicostas, 2003) Comment:kay-RA and kay-RB embryonic stage 6 -- 7   cephalic furrow   (Souid and Yanicostas, 2003) Comment:kay-RA ventral ectoderm   (Souid and Yanicostas, 2003) Comment:kay-RA posterior transverse furrow   (Souid and Yanicostas, 2003) Comment:kay-RA embryonic stage 7 -- 10   amnioserosa   (Souid and Yanicostas, 2003) Comment:kay-RA and kay-RB embryonic stage 9 -- 12   head | restricted   (Perkins et al., 1990) Comment:reference states 4-8 hr AEL embryonic stage 10 -- 11   stomodeal invagination   (Souid and Yanicostas, 2003) Comment:kay-RB embryonic stage 10 -- 12   embryonic leading edge cell | intense   (Souid and Yanicostas, 2003) Comment:kay-RA and kay-RB embryonic stage 10 -- 14   epithelium | faint   (Souid and Yanicostas, 2003) Comment:kay-RA embryonic stage 13 -- 14   midgut constriction 1 | precursor   (Souid and Yanicostas, 2003) Comment:kay-RB embryonic stage 15 -- 16   midgut constriction 1   (Souid and Yanicostas, 2003) Comment:kay-RB adult stage | female & oogenesis stage S9   centripetally migrating follicle cell   (Souid and Yanicostas, 2003) Comment:NOT polar follicle cell; kay-RB adult stage | femaleoogenesis stage S5 -- S10   nurse cell   (Souid and Yanicostas, 2003) Comment:kay-RA adult stage | female & oogenesis stage S10A   border follicle cell   (Souid and Yanicostas, 2003) Comment:early stage 10A only; kay-RB adult stage | female & oogenesis stage S10B   border follicle cell | subset   (Souid and Yanicostas, 2003) Comment:early stage 10B; kay-RB adult stage | femaleoogenesis stage S10B -- S12   border follicle cell | anterior & dorsal & subset   (Souid and Yanicostas, 2003) Comment:late stage 10B; kay-RB adult stage | female & oogenesis stage S13   polar follicle cell | posterior   (Souid and Yanicostas, 2003) Comment:kay-RB northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage     (Perkins et al., 1990) amnioserosa   (Perkins et al., 1990) dorsal ectoderm   (Perkins et al., 1990) embryonic stage 15   muscle attachment site   (Perkins et al., 1990) eo neuron   (Perkins et al., 1990) presumptive embryonic/larval peripheral nervous system | restricted   (Perkins et al., 1990) anal pad   (Perkins et al., 1990) embryonic/larval midgut   (Perkins et al., 1990) multidendritic neuron   (Perkins et al., 1990) embryonic/larval hindgut   (Perkins et al., 1990) prepupal stage P4(i)   embryonic/larval salivary gland   (Lehmann et al., 2002) Comment:10-12 hr APF RT-PCR Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism   (Souid and Yanicostas, 2003) Comment:kay-RA and kay-RB transcripts adult stage | male   organism | faint   (Souid and Yanicostas, 2003) Comment:kay-RA and kay-RB transcripts adult stage | female   organism   (Souid and Yanicostas, 2003) Comment:kay-RA and kay-RB transcripts ovary   (Souid and Yanicostas, 2003) Comment:kay-RA and kay-RB transcripts
Additional Descriptive Data
	kay transcripts are differentally expressed during oogenesis. kay-RA transcript is expressed in nurse cells from oogenesis stage 5 through stage 9. kay-RB transcription is first detected at oogenesis stage 9 in migrating columnar cells, with weak to no expression in anterior stretching cells posterior follicle cells. During early stage 10A kay-RB transcript levels decrease sharply and is transiently restricted to the anterior-most columnar cells before disappearing completely at mid-stage 10A. At early stage 10B, kay-RB transcript is strongly expressed in anterior stretched cells. From late stage 10B, kay-RB transcript accumulates to a high level in two rows of dorsal anterior follicle cells. During stage 13,kay-RB transcript is strongly expressed in a population of approximately 15 follicle cells located at the posterior pole of the oocyte. kay-RA transcript is uniformly distributed in preblastoderm embryos; this transcript is maternally deposited. kay-RB, by contrast, is not maternally deposited. Both kay transcripts are zygotically expressed at embryonic stage 4, in the amnioserosa anlage, and both continue to be expressed in the amnioserosa, and later in the embryonic leading edge cells. kay-RA is additionally expressed in the cephalic and posterior transverse furrows during gastrulation. kay-RB is additionally expressed in the stomodeal invagination, and in the cells that go on to form midgut constriction 1. (Souid and Yanicostas, 2003) kay transcript is expressed strongly in salivary glands at the beginning of the prepupal ecdysone pulse (10 hr APF). (Lehmann et al., 2002) kay transcripts are detected at a low level on northern blots in 4-8hr embryos and at a higher level in 8-12 and 12-16hr embryos. kay expression was shown to be restricted to certain cell types by in situ hybridization. It is expressed in cells of the head that are thought to be mesodermal soon after gastrulation (4-5hr) and persists until 8hr of embryogenesis. Early expression is also observed in the dorsal ectoderm and the amnioserosa. After ~11hr of embryogenesis, expression is restricted to a subset of PNS cells. They localize near the lateral chordotonal organs and may be the es (extrasensory) or md (multiple dendritic) neurons. Later expression is also observed in the muscle attachment sites, midgut, hindgut, and anal pads. (Perkins et al., 1990)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference oogenesis stage S11   dorsal appendage | restricted   (Boyle et al., 2010) immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11   amnioserosa   • nucleus (Reed et al., 2001) amnioserosa   • cytoplasm (Reed et al., 2001) Comment:weakly expressed in nucleus at this stage larval stage   motor neuron   (Sanyal et al., 2003) aCC neuron   (Sanyal et al., 2003) RP2 neuron   (Sanyal et al., 2003) RP3 neuron   (Sanyal et al., 2003) RP5 neuron   (Sanyal et al., 2003)
Additional Descriptive Data
	kay protein is expressed in the same motor neurons that express the Scer\GAL4C380 driver. (Sanyal et al., 2003) kay protein is expressed in stretch cells, floor cells and the first row of roof cells of the dorsal appendage primoridium. (Boyle et al., 2010)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0001297    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0001297 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 12-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0001297 expression level Developmental Stage   Expression Level embryo 00-02hr    396 embryo 02-04hr    370 embryo 04-06hr    510 embryo 06-08hr    756 embryo 08-10hr    671 embryo 10-12hr    1094 embryo 12-14hr    783 embryo 14-16hr    1486 embryo 16-18hr    1840 embryo 18-20hr    2724 embryo 20-22hr    2056 embryo 22-24hr    2016 larva L1    1370 larva L2    1187 larva L3 12hr old    1604 larva L3 puffstage 1-2    1174 larva L3 puffstage 3-6    2256 larva L3 puffstage 7-9    2504 white prepupae new    2724 white prepupae 12hr    1992 white prepupae 24hr    1151 pupae 2d postWPP    1005 pupae 3d postWPP    1902 pupae 4d postWPP    3744 adult male 01day    3113 adult male 05day    3607 adult male 30day    3267 adult female 01day    2754 adult female 05day    1131 adult female 30day    1148 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (396) embryo 02-04hr  (370) embryo 04-06hr  (510) embryo 06-08hr  (756) embryo 08-10hr  (671) embryo 10-12hr  (1094) embryo 12-14hr  (783) embryo 14-16hr  (1486) embryo 16-18hr  (1840) embryo 18-20hr  (2724) embryo 20-22hr  (2056) embryo 22-24hr  (2016) larva L1  (1370) larva L2  (1187) larva L3 12hr old  (1604) larva L3 puffstage 1-2  (1174) larva L3 puffstage 3-6  (2256) larva L3 puffstage 7-9  (2504) white prepupae new  (2724) white prepupae 12hr  (1992) white prepupae 24hr  (1151) pupae 2d postWPP  (1005) pupae 3d postWPP  (1902) pupae 4d postWPP  (3744) adult male 01day  (3113) adult male 05day  (3607) adult male 30day  (3267) adult female 01day  (2754) adult female 05day  (1131) adult female 30day  (1148) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    396 embryo 02-04hr    370 embryo 04-06hr    510 embryo 06-08hr    756 embryo 08-10hr    671 embryo 10-12hr    1094 embryo 12-14hr    783 embryo 14-16hr  1486 embryo 16-18hr  (1840) embryo 18-20hr  (2724) embryo 20-22hr  (2056) embryo 22-24hr  (2016) larva L1    1370 larva L2    1187 larva L3 12hr old  (1604) larva L3 puffstage 1-2    1174 larva L3 puffstage 3-6  (2256) larva L3 puffstage 7-9  (2504) white prepupae new  (2724) white prepupae 12hr  (1992) white prepupae 24hr    1151 pupae 2d postWPP    1005 pupae 3d postWPP  (1902) pupae 4d postWPP  (3744) adult male 01day  (3113) adult male 05day  (3607) adult male 30day  (3267) adult female 01day  (2754) adult female 05day    1131 adult female 30day    1148 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    396 embryo 02-04hr    370 embryo 04-06hr    510 embryo 06-08hr    756 embryo 08-10hr    671 embryo 10-12hr    1094 embryo 12-14hr    783 embryo 14-16hr    1486 embryo 16-18hr    1840 embryo 18-20hr    2724 embryo 20-22hr    2056 embryo 22-24hr    2016 larva L1    1370 larva L2    1187 larva L3 12hr old    1604 larva L3 puffstage 1-2    1174 larva L3 puffstage 3-6    2256 larva L3 puffstage 7-9    2504 white prepupae new    2724 white prepupae 12hr    1992 white prepupae 24hr    1151 pupae 2d postWPP    1005 pupae 3d postWPP    1902 pupae 4d postWPP    3744 adult male 01day    3113 adult male 05day    3607 adult male 30day    3267 adult female 01day    2754 adult female 05day    1131 adult female 30day    1148 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    396 embryo 02-04hr    370 embryo 04-06hr    510 embryo 06-08hr    756 embryo 08-10hr    671 embryo 10-12hr    1094 embryo 12-14hr    783 embryo 14-16hr    1486 embryo 16-18hr    1840 embryo 18-20hr    2724 embryo 20-22hr    2056 embryo 22-24hr    2016 larva L1    1370 larva L2    1187 larva L3 12hr old    1604 larva L3 puffstage 1-2    1174 larva L3 puffstage 3-6    2256 larva L3 puffstage 7-9    2504 white prepupae new    2724 white prepupae 12hr    1992 white prepupae 24hr    1151 pupae 2d postWPP    1005 pupae 3d postWPP    1902 pupae 4d postWPP    3744 adult male 01day    3113 adult male 05day    3607 adult male 30day    3267 adult female 01day    2754 adult female 05day    1131 adult female 30day    1148 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0001297 expression level Developmental Stage   Expression Level embryo 00-02hr    396 embryo 02-04hr    370 embryo 04-06hr    510 embryo 06-08hr    756 embryo 08-10hr    671 embryo 10-12hr    1094 embryo 12-14hr    783 embryo 14-16hr    1486 embryo 16-18hr    1840 embryo 18-20hr    2724 embryo 20-22hr    2056 embryo 22-24hr    2016 larva L1    1370 larva L2    1187 larva L3 12hr old    1604 larva L3 puffstage 1-2    1174 larva L3 puffstage 3-6    2256 larva L3 puffstage 7-9    2504 white prepupae new    2724 white prepupae 12hr    1992 white prepupae 24hr    1151 pupae 2d postWPP    1005 pupae 3d postWPP    1902 pupae 4d postWPP    3744 adult male 01day    3113 adult male 05day    3607 adult male 30day    3267 adult female 01day    2754 adult female 05day    1131 adult female 30day    1148 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (396) embryo 02-04hr  (370) embryo 04-06hr  (510) embryo 06-08hr  (756) embryo 08-10hr  (671) embryo 10-12hr  (1094) embryo 12-14hr  (783) embryo 14-16hr  (1486) embryo 16-18hr  (1840) embryo 18-20hr  (2724) embryo 20-22hr  (2056) embryo 22-24hr  (2016) larva L1  (1370) larva L2  (1187) larva L3 12hr old  (1604) larva L3 puffstage 1-2  (1174) larva L3 puffstage 3-6  (2256) larva L3 puffstage 7-9  (2504) white prepupae new  (2724) white prepupae 12hr  (1992) white prepupae 24hr  (1151) pupae 2d postWPP  (1005) pupae 3d postWPP  (1902) pupae 4d postWPP  (3744) adult male 01day  (3113) adult male 05day  (3607) adult male 30day  (3267) adult female 01day  (2754) adult female 05day  (1131) adult female 30day  (1148) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    396 embryo 02-04hr    370 embryo 04-06hr    510 embryo 06-08hr    756 embryo 08-10hr    671 embryo 10-12hr    1094 embryo 12-14hr    783 embryo 14-16hr  1486 embryo 16-18hr  1840 embryo 18-20hr  (2724) embryo 20-22hr  2056 embryo 22-24hr  2016 larva L1    1370 larva L2    1187 larva L3 12hr old  1604 larva L3 puffstage 1-2    1174 larva L3 puffstage 3-6  2256 larva L3 puffstage 7-9  (2504) white prepupae new  (2724) white prepupae 12hr  1992 white prepupae 24hr    1151 pupae 2d postWPP    1005 pupae 3d postWPP  1902 pupae 4d postWPP  (3744) adult male 01day  (3113) adult male 05day  (3607) adult male 30day  (3267) adult female 01day  (2754) adult female 05day    1131 adult female 30day    1148 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    396 embryo 02-04hr    370 embryo 04-06hr    510 embryo 06-08hr    756 embryo 08-10hr    671 embryo 10-12hr    1094 embryo 12-14hr    783 embryo 14-16hr    1486 embryo 16-18hr    1840 embryo 18-20hr    2724 embryo 20-22hr    2056 embryo 22-24hr    2016 larva L1    1370 larva L2    1187 larva L3 12hr old    1604 larva L3 puffstage 1-2    1174 larva L3 puffstage 3-6    2256 larva L3 puffstage 7-9    2504 white prepupae new    2724 white prepupae 12hr    1992 white prepupae 24hr    1151 pupae 2d postWPP    1005 pupae 3d postWPP    1902 pupae 4d postWPP    3744 adult male 01day    3113 adult male 05day    3607 adult male 30day    3267 adult female 01day    2754 adult female 05day    1131 adult female 30day    1148 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    396 embryo 02-04hr    370 embryo 04-06hr    510 embryo 06-08hr    756 embryo 08-10hr    671 embryo 10-12hr    1094 embryo 12-14hr    783 embryo 14-16hr    1486 embryo 16-18hr    1840 embryo 18-20hr    2724 embryo 20-22hr    2056 embryo 22-24hr    2016 larva L1    1370 larva L2    1187 larva L3 12hr old    1604 larva L3 puffstage 1-2    1174 larva L3 puffstage 3-6    2256 larva L3 puffstage 7-9    2504 white prepupae new    2724 white prepupae 12hr    1992 white prepupae 24hr    1151 pupae 2d postWPP    1005 pupae 3d postWPP    1902 pupae 4d postWPP    3744 adult male 01day    3113 adult male 05day    3607 adult male 30day    3267 adult female 01day    2754 adult female 05day    1131 adult female 30day    1148 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0001297    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0001297 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult crop, larval hindgut, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, larval/adult midgut, adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_18
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001297 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15507-RA;CG15509-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for kay Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele cell lethal | somatic clone kay1 lethal, with Scer\GAL4T80 kaydsRNA.Scer\UAS lethal (with kay1) kay2 lethal (with kay2) kay1 lethal | embryonic stage 13 | recessive kay1 kayS135103 lethal | embryonic stage 16 | recessive kayEY01644 kayEY08232 lethal | embryonic stage, with Scer\GAL4C-765 kaybZip.Scer\UAS lethal | embryonic stage | recessive kay1 kay2 kayunspecified lethal | embryonic stage | recessive | heat sensitive kay2 lethal | pharate adult stage kay1 kay2 lethal | pupal stage, with Scer\GAL4en-e16E kaydsRNA.Scer\UAS lethal | pupal stage, with Scer\GAL4pnr-MD237 kayGD9042 lethal | recessive kay1 kay2 semi-viable, with Scer\GAL4αTub84B.PL kayScer\UAS.cEa viable kayCC01156 kayEY12710 viable, with Scer\GAL4pnr-MD237 kayGD1469 viable, with Scer\GAL4αTub84B.PL kayN.Scer\UAS Sterility Allele fertile kayEY12710 Other Phenotypes Allele developmental rate defective | larval stage, with Scer\GAL4T80 kaydsRNA.Scer\UAS increased cell death, with Scer\GAL4en-e16E kaydsRNA.Scer\UAS increased cell death, with Scer\GAL4GMR.PF kaydsRNA.Scer\UAS mitotic cell cycle defective, with Scer\GAL4en-e16E kaydsRNA.Scer\UAS mitotic cell cycle defective, with Scer\GAL4T80 kaydsRNA.Scer\UAS neuroanatomy defective, with Scer\GAL4elav-C155 kayFbz.Scer\UAS neuroanatomy defective, with Scer\GAL4ey-OK107 kayFbz.Scer\UAS kayNIG.15507R neuroanatomy defective | conditional, with Scer\GAL4tey-5053A kayFbz.Scer\UAS neurophysiology defective, with Scer\GAL4elav-C155 kayFbz.Scer\UAS kayScer\UAS.cEa planar polarity defective kayαTub84B.PZ planar polarity defective, with Scer\GAL4h-1J3 kayFbz.Scer\UAS planar polarity defective, with Scer\GAL4hs.2sev kayEY12710 kayFbz.Scer\UAS planar polarity defective, with Scer\GAL4pnr-MD237 kayGD1469 planar polarity defective | somatic clone kayEY01644 kayP54 planar polarity defective | somatic clone, with Scer\GAL4Act.PU kayEY12710 visible kayunspecified visible, with kay1, kay2 kayhs.PZ visible, with kay1, kayhs.PZ kay2 visible, with kay1/kay2 kayhs.PZ visible, with kay2, kayhs.PZ kay1 visible, with Scer\GAL4ap-md544 kaybZip.Scer\UAS visible, with Scer\GAL4ey.3.5.Exel kayFbz.Scer\UAS visible, with Scer\GAL4ey.PH kaydsRNA.Scer\UAS visible, with Scer\GAL4GMR.PF kayEP3084 visible, with Scer\GAL4MZ980 kayNA1a.Scer\UAS visible, with Scer\GAL4pnr-MD237 kaybZip.Scer\UAS kayGD1469 visible (with kay1), with kayhs.PZ kay2 visible (with kay2), with kayhs.PZ kay1 visible | recessive kay2 wild-type kayhs.PZ kayαTub84B.PZ wound healing defective, with Scer\GAL4en-e16E kayN-Ala.Scer\UAS wound healing defective (with kay1) kay2 wound healing defective (with kay2) kay1 wound healing defective | partially, with Scer\GAL4en-e16E kaypan-Ala.Scer\UAS Phenotype manifest in Allele adult midgut precursor cell, with Scer\GAL448Y kayFbz.Scer\UAS adult thorax kayunspecified adult thorax, with Scer\GAL4ap-md544 kaybZip.Scer\UAS adult thorax, with Scer\GAL4MZ980 kayNA1a.Scer\UAS adult thorax, with Scer\GAL4pnr-MD237 kayScer\UAS.cEa kaybZip.Scer\UAS adult thorax | dorsal kay2 adult thorax | dorsal, with kay1, kay2 kayhs.PZ adult thorax | dorsal, with kay1, kayhs.PZ kay2 adult thorax | dorsal, with kay1/kay2 kayhs.PZ adult thorax | dorsal, with kay2, kayhs.PZ kay1 adult thorax | dorsal (with kay1), with kayhs.PZ kay2 adult thorax | dorsal (with kay2), with kayhs.PZ kay1 anterior crossvein, with Scer\GAL4dpp.blk1 kayFbz.Scer\UAS anterior crossvein, with Scer\GAL4en-e16E kayFbz.Scer\UAS axon, with Scer\GAL4ey-OK107 kayFbz.Scer\UAS kayNIG.15507R bouton, with Scer\GAL4BG380 kayFbz.Scer\UAS bouton, with Scer\GAL4elav-C155 kayFbz.Scer\UAS cuprophilic cell, with Scer\GAL448Y kayFbz.Scer\UAS cuprophilic cell, with Scer\GAL4hs.PB kayFbz.Scer\UAS cuprophilic cell, with Scer\GAL4unspecified kayFbz.Scer\UAS dorsal appendage | maternal effect | somatic clone kay2 kayS135103 dorsal closure embryo kay1 kay2 dorsal closure embryo (with kay1) kay2 dorsal closure embryo (with kay2) kay1 egg | maternal effect | somatic clone kay2 kayS135103 embryo | dorsal kay1 kay2 embryonic/first instar larval cuticle kay1 embryonic/first instar larval cuticle, with Scer\GAL4C-765 kaybZip.Scer\UAS embryonic dorsal epidermis kay1 kay2 kayunspecified embryonic dorsal epidermis (with kay1) kay2 embryonic dorsal epidermis (with kay2) kay1 embryonic epidermis kay1 embryonic epidermis | dorsal kay1 kay2 embryonic head kay1 embryonic ventral epidermis kay1 kay2 eye, with Scer\GAL4ey.3.5.Exel kayFbz.Scer\UAS eye, with Scer\GAL4ey.PH kaybZip.Scer\UAS kaydsRNA.Scer\UAS eye, with Scer\GAL4GMR.PF kayEP3084 kaydsRNA.Scer\UAS eye, with Scer\GAL4h-1J3 kayFbz.Scer\UAS eye, with Scer\GAL4hs.2sev kayFbz.Scer\UAS eye, with Scer\GAL4unspecified kayFbz.Scer\UAS eye photoreceptor cell, with Scer\GAL4h-1J3 kayFbz.Scer\UAS eye photoreceptor cell, with Scer\GAL4hs.2sev kayFbz.Scer\UAS eye photoreceptor cell | somatic clone kayEY01644 kayP54 follicle cell | somatic clone kay1 heart primordium kaydsRNA.cKa kaydsRNA.si.cKa imaginal disc kay2 Kenyon cell, with Scer\GAL4ey-OK107 kayFbz.Scer\UAS kayNIG.15507R mesothoracic cleft (with kay1) kay2 mesothoracic cleft (with kay2) kay1 mesothoracic tergum, with Scer\GAL4pnr-MD237 kayGD1469 midgut interstitial cell, with Scer\GAL448Y kayFbz.Scer\UAS neuromuscular junction, with Scer\GAL4BG380 kayFbz.Scer\UAS neuromuscular junction | larval stage, with Scer\GAL4elav-C155 kayFbz.Scer\UAS nurse cell & nucleus | somatic clone kay2 kayS135103 ommatidium kayαTub84B.PZ ommatidium, with Scer\GAL4GMR.PF kayEP3084 ommatidium, with Scer\GAL4h-1J3 kayFbz.Scer\UAS ommatidium, with Scer\GAL4hs.2sev kayEY12710 kayFbz.Scer\UAS ommatidium | somatic clone kayEY01644 kayP54 photoreceptor cell R4 | somatic clone, with Scer\GAL4Act.PU kayEY12710 pigment cell, with Scer\GAL4GMR.PF kayEP3084 kaydsRNA.Scer\UAS pupal thorax kay2 salivary gland kay2 scutellum kayunspecified segmental nerve | conditional, with Scer\GAL4tey-5053A kayFbz.Scer\UAS stage S9 oocyte | somatic clone kay1 stage S14 oocyte | somatic clone kay2 kayS135103 synapse, with Scer\GAL4elav-C155 kayFbz.Scer\UAS terminal button, with Scer\GAL4elav-C155 kayFbz.Scer\UAS thorax, with Scer\GAL469B kayN-Ala.Scer\UAS kaypan-Ala.Scer\UAS trichogen cell, with Scer\GAL4pnr-MD237 kayGD1469 wing kay1 kay2 wing, with Scer\GAL4sd-SG29.1 kaydsRNA.Scer\UAS wing | posterior, with Scer\GAL4en-e16E kaydsRNA.Scer\UAS wing disc kay1 wing vein, with Scer\GAL4en-e16E kayC-Ala.Scer\UAS kayFbz.Scer\UAS kaypan-Ala.Scer\UAS wing vein, with Scer\GAL4sd-SG29.1, kay1 kayFbz.Scer\UAS wing vein, with Scer\GAL4sd-SG29.1, kayFbz.Scer\UAS kay1 wing vein L2, with Scer\GAL4sd-SG29.1 kayFbz.Scer\UAS wing vein L3, with Scer\GAL4dpp.blk1, kay1 kayFbz.Scer\UAS wing vein L3, with Scer\GAL4dpp.blk1, kayFbz.Scer\UAS kay1 wing vein L4, with Scer\GAL4sd-SG29.1 kayFbz.Scer\UAS wing vein L5, with Scer\GAL4en-e16E kayFbz.Scer\UAS wing vein L5, with Scer\GAL4en-e16E, kay1 kayFbz.Scer\UAS wing vein L5, with Scer\GAL4en-e16E, kayFbz.Scer\UAS kay1 wing vein L5, with Scer\GAL4sd-SG29.1 kayFbz.Scer\UAS
Classical Alleles ( 20 )
For All Classical Alleles Show
Allele of kay Class Mutagen Stocks Known lesion kay1 amorphic allele - genetic evidence ethyl methanesulfonate 2 Yes kay5-HA-1081 1 -- kayd02473 P-element activity 1 -- kayDG24501 1 -- kaye01390 1 -- kayEY00283 P-element activity 1 -- kayEY01644 P-element activity 1 Yes kayEY08232 P-element activity 1 Yes kayEY12710 P-element activity 1 -- kayf02002 piggyBac transposase 1 -- kayNP3511 1 -- kay2 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- kayBG01495 0 -- kayCC01156 P-element activity 0 Yes kaye03091 piggyBac transposase 0 -- kayED6315 0 Yes kayEP3084 0 -- kayP54 P-element activity 0 Yes kayS135103 hypomorphic allele - genetic evidence P-element activity 0 Yes kayunspecified 0 --
Alleles Carried on Transgenic Constructs ( 26 )
For All Alleles Carried on Transgenic Constructs Show
Allele of kay Class Mutagen Stocks Known lesion kayFbz.Scer\UAS in vitro construct - regulatory fusion 2 Yes kayGD1469 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes kayGD9042 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes kayHMS00254 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes kayJF01273 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes kayJF01380 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes kayJF02804 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes kayScer\UAS.cEa in vitro construct - regulatory fusion 1 Yes kaybZip.Scer\UAS in vitro construct - regulatory fusion 0 Yes kayC-Ala.Scer\UAS in vitro construct - site directed mutagenesis 0 Yes kaydsRNA.cKa in vitro construct - RNAi 0 Yes kaydsRNA.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes kaydsRNA.si.cKa in vitro construct - RNAi 0 Yes kayhs.PZ in vitro construct - regulatory fusion 0 Yes kayMtnA.T:SV5\V5 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes kayN-Ala.Scer\UAS in vitro construct - site directed mutagenesis 0 Yes kayN.Scer\UAS in vitro construct - regulatory fusion 0 Yes kayNA1a.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes kayNIG.15507R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes kaypan-Ala.Scer\UAS in vitro construct - site directed mutagenesis 0 Yes kayScer\UAS.C.T:Ecol\lexA in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes kayScer\UAS.cHa in vitro construct - regulatory fusion 0 Yes kayScer\UAS.N.T:Ecol\lexA in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes kayScer\UAS.T:Ecol\lexA in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes kayScer\UAS.T:Zzzz\TAP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes kayαTub84B.PZ in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)01215 (Cook, 2006.1.31, Riesgo-Escovar and Hafen, 1997) Df(3R)ED6316 (Ryder and Roote, 2004.11.10) Df(3R)J55 (Jurgens et al., 1984) Df(3R)kay1 (Zeitlinger, 1999.9.17) Ts(YLt;3Lt)B172 (Jurgens et al., 1984, Tearle and Nusslein-Volhard, 1987) Ts(YSt;3Lt)R128 (Jurgens et al., 1984)
Not disrupted in	Df(3R)A113 (Tearle and Nusslein-Volhard, 1987)
Partially disrupted in	Df(3R)ED6315 (Weber et al., 2008)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1469} NA P{GD9042} NA P{lexA-Fos.C} NA P{lexA-Fos.N} NA P{lexA-Fos} NA P{TRiP.HMS00254} NA P{TRiP.JF01273} NA P{TRiP.JF01380} NA P{TRiP.JF02804} NA P{UAS-D-fosC-Ala} NA P{UAS-D-fosN-Ala} NA P{UAS-D-fospan-Ala} NA P{UAS-Fra.Fbz} NA P{UAS-Fra} NA P{UAS-kay.bZip} NA P{UAS-kay.N} NA P{UAS-kay.TAP} NA characterization construct P{hs.sev-Jra::kay.FJF} NA P{hs.sev-Jra::kay.JFJ} NA P{NIG.15507R} NA P{αTub84B-kay.Z} NA heat-shock construct P{hs-kay.Z} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}EP902 NA P{EP}kayEP3084 NA P{EPgy2}kayEY00283 NA P{EPgy2}kayEY01644 NA P{EPgy2}kayEY08232 NA P{EPgy2}kayEY12710 NA P{XP}kayd02473 NA miscellaneous insertions P{}sroP54 NA P{GT1}kayBG01495 NA P{PTT-GC}kayCC01156 NA P{RS5}kay5-HA-1081 NA P{SUPor-P}KG06253 NA P{wHy}kayDG24501 NA PBac{RB}kaye01390 NA PBac{RB}kaye03091 NA PBac{WH}kayf02002 NA insertion of enhancer trap binary system P{GawB}kayNP3511 No insertion of enhancer trap P{lacW}kayS135103 No
Gene Ontology: Function, Process & Cellular Component ( 28 unique terms )
Terms Based on Experimental Evidence ( 24 terms )
Molecular Function
CV term Evidence References
DNA binding inferred from direct assay (Perkins et al., 1990) protein binding inferred from physical interaction with chm (Miotto et al., 2006) inferred from physical interaction with Cka (Chen et al., 2002) inferred from physical interaction with Rpd3 (Miotto et al., 2006) protein heterodimerization activity inferred from physical interaction with Jra (Perkins et al., 1990) RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription inferred from direct assay (Miotto et al., 2006) sequence-specific DNA binding inferred from direct assay (Hyun et al., 2006) sequence-specific DNA binding RNA polymerase II transcription factor activity inferred from direct assay (Perkins et al., 1990)
Biological Process
CV term Evidence References
antimicrobial humoral response inferred from mutant phenotype (Kleino et al., 2005) border follicle cell migration inferred from genetic interaction with Pvr (Mathieu et al., 2007) collateral sprouting of injured axon inferred from mutant phenotype (Xiong et al., 2010) compound eye development inferred from mutant phenotype (Cerrato et al., 2006) dorsal closure inferred from mutant phenotype (Grima et al., 2008) imaginal disc fusion, thorax closure inferred from mutant phenotype (Cerrato et al., 2006) ovarian follicle cell migration inferred from mutant phenotype (Dequier et al., 2001) positive regulation of transcription from RNA polymerase II promoter inferred from direct assay (Perkins et al., 1990) R3/R4 cell fate commitment inferred from mutant phenotype (Weber et al., 2008) regulation of cyclin-dependent protein kinase activity involved in G2/M inferred from mutant phenotype (Hyun et al., 2006) response to wounding inferred from mutant phenotype (Ramet et al., 2002) second mitotic wave involved in compound eye morphogenesis inferred from mutant phenotype (Hyun et al., 2006) synaptic growth at neuromuscular junction inferred from genetic interaction with Jra (Franciscovich et al., 2008) wing disc development inferred from mutant phenotype (Hyun et al., 2006) wound healing inferred from mutant phenotype (Bosch et al., 2005, Ramet et al., 2002)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Reed et al., 2001) nucleus inferred from direct assay (Perkins et al., 1990, Reed et al., 2001, Woolner et al., 2005) transcription factor complex inferred from physical interaction with Jra (Perkins et al., 1990)
Terms Based on Predictions or Assertions ( 9 terms )
Molecular Function
CV term Evidence References
protein heterodimerization activity inferred from sequence or structural similarity (Fassler et al., 2002) sequence-specific DNA binding transcription factor activity non-traceable author statement (Swiss-Prot Project Members, 1991.5.1) traceable author statement (Gibson and Schubiger, 2001) transcription factor binding non-traceable author statement (Swiss-Prot Project Members, 1991.5.1) traceable author statement (Van Aelst and Symons, 2002)
Biological Process
CV term Evidence References
dorsal closure non-traceable author statement (Van Aelst and Symons, 2002) traceable author statement (Noselli and Agnes, 1999, Harden, 2002) establishment of planar polarity non-traceable author statement (Mlodzik, 2002) imaginal disc fusion, thorax closure traceable author statement (Gibson and Schubiger, 2001) JNK cascade non-traceable author statement (Noselli and Agnes, 1999) R3/R4 cell fate commitment traceable author statement (Mlodzik, 2002)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (Swiss-Prot Project Members, 1991.5.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions kay allele Gene References kay1 bsk (Riesgo-Escovar and Hafen, 1997) eg (Gritzan et al., 2002) Egfr (Ciapponi et al., 2001) Jra::kay (Ciapponi and Bohmann, 2002) knrl (Gritzan et al., 2002) mbf1 (Jindra et al., 2004) puc (Zeitlinger and Bohmann, 1999, Ramet et al., 2002) svp (Gritzan et al., 2002) kay2 bsk (Riesgo-Escovar and Hafen, 1997, Dequier et al., 2001) Cka (Chen et al., 2002) Egfr (Ciapponi et al., 2001) fz (Ciapponi et al., 2001) Jra (Riesgo-Escovar and Hafen, 1997) Jra::kay (Ciapponi and Bohmann, 2002) puc (Zeitlinger and Bohmann, 1999, Ramet et al., 2002) rl (Ciapponi et al., 2001, Gritzan et al., 2002) sev (Ciapponi et al., 2001) svp (Gritzan et al., 2002) kayC-Ala.Scer\UAS fz (Ciapponi et al., 2001) sev (Ciapponi et al., 2001) kayFbz.Scer\UAS Egfr (Ciapponi et al., 2001) rl (Ciapponi et al., 2001) kayN.Scer\UAS eg (Gritzan et al., 2002) kayN-Ala.Scer\UAS fz (Ciapponi et al., 2001) kaypan-Ala.Scer\UAS fz (Ciapponi et al., 2001) sev (Ciapponi et al., 2001) kayS135103 bsk (Dequier et al., 2001) kayScer\UAS.cEa eg (Gritzan et al., 2002) Jra (Sanyal et al., 2002) rl (Ciapponi et al., 2001) unspecified Atx2 (Sun et al., 2006) CG32137 (Sun et al., 2006) chm (Miotto et al., 2006) CrebB-17A (Sanyal et al., 2002) D1 (Sun et al., 2006) dnc (Sanyal et al., 2002) H (Mueller et al., 2005) hep (Miotto et al., 2006) jigr1 (Sun et al., 2006) jing (Sun et al., 2006) Mnn1 (Cerrato et al., 2006) Ppt1 (Buff et al., 2007) puc (Sanyal et al., 2002) Pvr (Mathieu et al., 2007) scrib (Uhlirova and Bohmann, 2006) slpr (Polaski et al., 2006) XNP (Sun et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 533679 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0001297 DroID - A comprehensive database of gene and protein interactions. • FBgn0001297 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 3772082
Orthologs
Genome-wide drosophilid orthologs	Dana\GF23375 Dere\GG11694 Dgri\GH14331 Dmoj\GI10426 Dper\GL23721 Dpse\GA30111 Dsec\GM12821 Dsim\GD21465 Dvir\GJ10642 Dwil\GK11924 Dyak\GE23884
Curated drosophilid orthologs	Dana\kay (Hudson et al., 2007) Dere\kay (Hudson et al., 2007) Dgri\kay (Hudson et al., 2007) Dmoj\kay (Hudson et al., 2007) Dper\kay (Hudson et al., 2007) Dpse\GA30111   Dpse\kay (Hudson et al., 2007) Dsec\kay (Hudson et al., 2007) Dsim\kay (Hudson et al., 2007) Dvir\kay (Hudson et al., 2007) Dwil\kay (Hudson et al., 2007) Dyak\kay (Hudson et al., 2007)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL008953-PC Aedes aegypti (mosquito) AGAP001093-PA Anopheles gambiae (mosquito) XP_001949014.1 Acyrthosiphon pisum (pea aphid) BGIBMGA005140-PA Bombyx mori (silk worm) CE39151 Caenorhabditis elegans (worm) ENSCINP00000007607 Ciona intestinalis (sea squirt) cn02010 Cryptococcus neoformans (yeast-like fungus) CPIJ003767 Culex pipens (mosquito) RP44314 Caenorhabditis remanei (nematode) 170504 Capitella spl (polychaete worm) DDB0220091 Dictyostelium discoideum (amoeba) 302198 Daphnia pulex (daphnia) ENSDARP00000043297 Danio rerio (zebra fish) 178275 Hypsipyla robusta (cedar shoot borer) XP_001601050.1 Nasonia vitripennis (wasp) PHUM007841-PA Pediculus humanus (human body louse) XP_975800.1 Tribolium castaneum (red flour beetle) ENSTNIP00000002886 Tetraodon nigroviridis (green spotted pufferfish) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15834 NV15740 LH14843 ISCW010628 FBgn0241033 FBgn0213935 FBgn0197920 FBgn0192899 FBgn0167757 JGI_V11_302198 FBgn0073810 FBgn0161311 FBgn0133190 FBgn0121807 FBgn0103990 FBgn0100369 CPIJ003767 BGIBMGA005140 ACYPI005814 GB30215 GB12212 AGAP001093 AAEL008953 PHUM237480 GLEAN_11870
Stocks & Reagents
Stocks Listed in FlyBase ( 21 )
Bloomington	7213 w1118; P{UAS-Fra}2 7214 w1118; P{UAS-Fra.Fbz}5 7215 y1 w1118; P{UAS-Fra.Fbz}7 27722 y1 v1; P{TRiP.JF02804}attP2 31322 y1 v1; P{TRiP.JF01273}attP2 31391 y1 v1; P{TRiP.JF01380}attP2
Harvard	- P{XP}kayd02473 - PBac{RB}kaye01390 - PBac{WH}kayf02002
Kyoto	125056 w1118; P{RS5}kay5-HA-1081
VDRC	v19512 w1118; P{GD9042}v19512 v6212 w1118; P{GD1469}v6212/TM3
	More stocks available...
Genomic Clones ( 2 )
	BACR02E15 BACR02O03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 143 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD16083 LP01201 SD04477
Other clones	DPiM_LP01201
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT09454 GH17748 HL02125 LP10175 LP22630 LP23220 RE07490 RE21432 RE51660 RE73728 RH29036 RH37180 RH56516 RH63945 RH66540 SD02888 SD03077 SD03648 SD03778 SD04648 SD05631 SD07670 SD10965 SD14604 SD16074 SD20509 SD23221 SD24153 SD25395 SD27525 SD27781
Other clones	15789 18821 58543 66326 105634 105743 105950 108250 124162 147269 159316 176492 179680 214407.23 281506 523735 524312 525437 527789 527936 528079 533553 533965 561822 562021 562099 569043 569120 CK01.5B.A8 CK01.85B.E8 CK01.87C.E1 CK01.112D.E10 CK01.126B.D12 CK01.132D.B12 Dmel_dig_003871_0719_0430 EK001851 EK042306 EK060405 EK066909 EK067552 EK069117 EK084503 EK096946 EK101140 EK104303 EK168701 EK169507 EK170202 EK184201 EK230564 EK244011 EK244149 EK246664 EK250201 EK262252 EK281243 EK284456 EK306737 EK308402 EN04216 EN04601 EN05002 EN05140 EN06519 EN08058 EN08209 EN08461 EN09735 EN09932 EN13213 EN13551 EN13707 EN13716 EN14558 EP03504 EP04952 EP21214 ESG018b.E21_E01 FGC026G07 FGH112D10 FGH116A03 FGM219G04 FGM323F04 FGM323F08 LD13263 RP003031976 RP003043766 RP003077999 RP003127345 RP003215613 RP003266848 RP003275541 RP003276410 RP003320276 RP003337381 RP003355822 RP003387643 RP003432697 RP003503869 RP003509136 RP003536504 RP003602651 RP003617022 RP003635769 RP003639268 RP003667956 SD14071 SD20869
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0001297 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43509 43510
Antibody Information
	polyclonal (Hartwig et al., 2008, Freeman et al., 2010)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: kay CG15507 (Hudson and Goldstein, 2005)
Additional comments	The sro (shroud) complementation group is not allelic to the kay gene (as stated in FBrf0157169) but instead corresponds to the CG12068 annotation; the sro[1] and sro[O4-105] alleles each have a nonsense mutation that disrupts the catalytic centre of the predicted CG12068 protein, the P{}sro[P54] insertion which is inserted in the region upstream of kay causes a large reduction in the CG12068 transcript level as well as affecting kay and the lethality of the sro[1] allele is rescued by overexpression of CG12068. (Niwa et al., 2010) Annotations CG15507 and CG15509 merged as CG33956 (which corresponds to kay) in release 4.2 of the genome annotation. (FlyBase Genome Annotators, 2005) FlyBase curator comment: The sro (shroud) complementation group is not allelic to the kay gene (as stated in FBrf0157169) but instead corresponds to the CG12068 annotation (see FBrf0210924). (Giesen et al., 2003)
Other Comments
	The kay protein binds specifically to the promoter region of CycB. (Hyun et al., 2006) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a specific decrease in AttA activity in response to heat-killed E.coli when assayed in S2 cells. (Kleino et al., 2005) RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) kay is required for wound healing. (Ramet et al., 2002) kay is necessary for the proper posteriorward migration of the main body follicle cells during stage 9 of oogenesis. It also controls, from stage 11 onwards, the morphogenetic reorganisation of the follicle cells that are committed to secrete the dorsal appendages. (Dequier et al., 2001) kay function is required for its own upregulation. (Szuts and Bienz, 2000) kay is required for thorax closure during metamorphosis. (Zeitlinger and Bohmann, 1999) In vitro protein binding assays demonstrate kay is a poor candidate for a transcriptional activator acting through the Ubx cAMP response element (CRE). (Eresh et al., 1997) dpp, by inducing kay, broadly defines an endodermal region which thus becomes predisposed to express lab. kay cooperates with signal-activated response factors to confer the precise pattern of lab expression in the endoderm. (Riese et al., 1997) Mutations in kay are described. (Riesgo-Escovar and Hafen, 1997) kay is required for dorsal closure and elongation of cells in the lateral epidermis during embryogenesis. (Zeitlinger et al., 1997) The DebA upstream region contains a binding site for the Jra/kay (AP-1) protein complex, which negatively regulates its transcription. (Goldstein, 1995) kay lies within 12kb of ca. (Perkins et al., 1990) kay is a developmentally regulated transcription factor and its potential interplay with Jra may play an important role in cell-type specific transcription during embryonic development. (Perkins et al., 1990) The AP-1 complex encodes two proteins that have functional and structural properties in common with mammalian Fos and Jun proto-oncogene products; kay and Jra, respectively. The biochemical properties of the kay gene product have been examined in vitro and the expression pattern in developing embryos studied. (Perkins et al., 1990)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_001032405 NM_001032406 NM_001032407 NM_001032408 RefSeq (Proteins) • NP_001027577 NP_001027578 NP_001027579 NP_001027580 DDBJ / EMBL / GenBank • AAF56934.1 AAF56935.2 AAF69496 AAK11267 AAK11268 AAL39950 AAN14187.1 AAS87366 AAZ83991 AAZ83992 AAZ83993 AAZ83994 AC007892 AF238310 AF332657 AF332658 AF332659 AF332660 AI532844 AW944364 AY069805 AY574373 BZ665498 BZ665561 CAA38082 CL528091 CL943540 CZ472839 CZ480858 CZ484500 X54143 Entrez Gene - A searchable database of RefSeq genes. • 3772082 UniProtKB/Swiss-Prot • A8MPH9 P21525
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Fos transforming protein (IPR000837) Basic-leucine zipper (bZIP) transcription factor (IPR004827) bZIP transcription factor, bZIP-1 (IPR011616)
Linkouts
	BioGRID - A database of protein and genetic interactions • 533679 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0001297 DroID - A comprehensive database of gene and protein interactions. • FBgn0001297 DRSC - Results from RNAi screens. • FBgn0001297 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001297 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15507-RA;CG15509-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0001297 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 90562 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 43509 43510 InParanoid A subset of ortholog calls from InParanoid. • AAEL008953-PC Aedes aegypti (mosquito) AGAP001093-PA Anopheles gambiae (mosquito) XP_001949014.1 Acyrthosiphon pisum (pea aphid) BGIBMGA005140-PA Bombyx mori (silk worm) CE39151 Caenorhabditis elegans (worm) ENSCINP00000007607 Ciona intestinalis (sea squirt) cn02010 Cryptococcus neoformans (yeast-like fungus) CPIJ003767 Culex pipens (mosquito) RP44314 Caenorhabditis remanei (nematode) 170504 Capitella spl (polychaete worm) DDB0220091 Dictyostelium discoideum (amoeba) 302198 Daphnia pulex (daphnia) ENSDARP00000043297 Danio rerio (zebra fish) 178275 Hypsipyla robusta (cedar shoot borer) XP_001601050.1 Nasonia vitripennis (wasp) PHUM007841-PA Pediculus humanus (human body louse) XP_975800.1 Tribolium castaneum (red flour beetle) ENSTNIP00000002886 Tetraodon nigroviridis (green spotted pufferfish) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /gene/fos1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 3772082 modMine - Data generated by the modENCODE project. • FBgn0001297 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15834 NV15740 LH14843 ISCW010628 FBgn0241033 FBgn0213935 FBgn0197920 FBgn0192899 FBgn0167757 JGI_V11_302198 FBgn0073810 FBgn0161311 FBgn0133190 FBgn0121807 FBgn0103990 FBgn0100369 CPIJ003767 BGIBMGA005140 ACYPI005814 GB30215 GB12212 AGAP001093 AAEL008953 PHUM237480 GLEAN_11870
Synonyms & Secondary IDs ( 34 )
Reported As
Symbol Synonym	AP-1 (Harden, 2005, Short et al., 2005, Zhang et al., 2002, Zeitlinger et al., 1997, Mlodzik et al., 1993, Jindra et al., 2005, Monroe et al., 2006, Juarez et al., 2007, Bhaskara et al., 2006, Casas-Tinto et al., 2008, Wang et al., 2007, Etter et al., 2005, Franciscovich et al., 2008) AP1 (Cerrato et al., 2004, Sanyal et al., 2003, Moussian and Uv, 2005, Sanyal et al., 2003, Mrinal and Nagaraju, 2010) c-Fos (Muralikrishna and Parnaik, 2001) c-fos (Domingues and Ryoo, 2008) CG15507 (Mueller et al., 2005, Giesen et al., 2003, Sun et al., 2006, Hudson and Goldstein, 2008) CG15509 (Kleino et al., 2005, Hudson and Goldstein, 2005, Kim et al., 2004, ) CG33956 (Perkins et al., 2009, Ni et al., 2008, Ni et al., 2010.12.1) dAP-1 (Wang and Goldstein, 1993) DFos (Miotto et al., 2006, Hoeffer et al., 2003, Brennan and Anderson, 2004, Varfolomeev and Ashkenazi, 2004, Pena-Rangel et al., 2002, Dequier et al., 2001, Gibson and Schubiger, 2001, Dobens et al., 2001, Dequier et al., 1999, Ip and Davis, 1998, Riesgo-Escovar and Hafen, 1997, Luo et al., 2007, Grima et al., 2008, Guichard et al., 2006) Dfos (Woolner et al., 2005, Bosch et al., 2005, Chen et al., 2002, Nedelcheva et al., 2001, Van Aelst and Symons, 2002, Suzanne et al., 2001, Rousseau and Goldstein, 2001, Rousseau et al., 2001, Szuts and Bienz, 2000, Dequier et al., 2000, Noselli and Agnes, 1999, Agnes and Noselli, 1999, Goberdhan and Wilson, 1998, Noselli et al., 1998, Bosch et al., 2005, Nazario-Yepiz and Riesgo-Escovar, 2007, Lehmann et al., 2002, Casas-Tinto et al., 2008, Lee et al., 2007, Casas-Tinto et al., 2008, Nichols et al., 2002) DFOS (Chen et al., 2002, Xia and Karin, 2004, Chen et al., 2003, Reed et al., 2001, Chen et al., 2000, Anonymous, 1998) D-fos (Kockel et al., 2001, Salgado and Riesgo-Escovar, 2004, Zeitlinger et al., 1997, Dickson, 1995, Casas-Tinto et al., 2007, Lee et al., 2008) D-Fos (Jindra et al., 2004, Ciapponi and Bohmann, 2002, Ciapponi and Bohmann, 2002, Dobens and Raftery, 2001, Blau and Young, 1999, Zeitlinger and Bohmann, 1999, Zeitlinger et al., 1998, Bienz, 1997, Riese et al., 1997, Eresh et al., 1997, Llense and Martín-Blanco, 2008) d-fos (Jindra et al., 2003) dFos (Waltzer and Bienz, 1998, Buff et al., 2007, Franciscovich et al., 2008, Tokusumi et al., 2009) dfos (Wu et al., 2008) D-fos/kay (Friedman and Perrimon, 2006) dFRA (Taylor, 2000, Briata et al., 1993, Bonneton and Wegnez, 1995, Perkins et al., 1988) DFra (Riesgo-Escovar and Hafen, 1997) dFra (Bausenwein et al., 1993, Perkins et al., 1990, ) dlhD   fbz (Etter et al., 2005) fos (Riesgo-Escovar et al., 2004, Cerrato et al., 2004, Sanyal et al., 2002, Ciapponi and Bohmann, 2002, Rousseau, 2001.1.2, Rousseau, 2001.1.2, Rousseau, 2001.1.2, Rousseau, 2001.1.2, Nairz and Hafen, 1999, Hyun et al., 2006, Cerrato et al., 2006, Uhlirova and Bohmann, 2006, Mathieu et al., 2007, Pearson et al., 2009, Pierre et al., 2008, Haussmann et al., 2008, Franciscovich et al., 2008, Sekyrova et al., 2010) Fos (Tran and Berg, 2003, Miotto et al., 2004, Kaltschmidt et al., 2002, Jacinto et al., 2002, Settleman, 2001, Jacinto et al., 2001, Mlodzik, 2002, Sanyal et al., 2003, Schaeffer et al., 2002, Zeitlinger et al., 1997, Mlodzik et al., 1993, Bohmann et al., 1994, Luo et al., 2006, Mace et al., 2005, Juarez et al., 2007, Wu et al., 2008, Hartwig et al., 2008, Kim et al., 2009, Rallis et al., 2010, Sanyal et al., 2003, Etter et al., 2005, Xiong et al., 2010, Lee et al., 2010, Boyle et al., 2010) Fra (Anonymous, 1998, ) fra (Mrinal and Nagaraju, 2010) kay (Mace et al., 2005, Hudson et al., 2007, Zhang et al., 2006, Lehmann et al., 2002, Niwa et al., 2010, Zhao et al., 2008, Neuman-Silberberg, 2007, Souid and Yanicostas, 2003, Cerrato et al., 2006, Buszczak et al., 2007, Mace et al., 2005, Polaski et al., 2006, Hudson and Goldstein, 2008, Hudson et al., 2007, Luo et al., 2007, Weake et al., 2011, Tokusumi et al., 2009, Zeitlinger et al., 2007, Weber et al., 2008, Grima et al., 2008, Kim et al., 2005, Dubruille et al., 2009, Giesen et al., 2003, Jurgens et al., 1984, Zhou et al., 2008, Zhang and Arnosti, 2011) Kay (Herranz et al., 2010, Stielow et al., 2008)
Name Synonym	activator protein 1 (Bhaskara et al., 2006) Dfos/kayak (Souid and Yanicostas, 2003) dorsal holes D   Fos (Collins et al., 2006) Fos-related antigen (Mrinal and Nagaraju, 2010) kayak (Hudson et al., 2007, Niwa et al., 2010, Zhao et al., 2008, Neuman-Silberberg, 2007, Hudson and Goldstein, 2008, Hudson et al., 2007, Luo et al., 2007, Stofanko et al., 2008, Hartwig et al., 2008, Pierre et al., 2008, Grima et al., 2008, Giesen et al., 2003, Jurgens et al., 1984, Mourikis et al., 2010, Boyle et al., 2010, Magwire et al., 2010) Kayak (Buff et al., 2007)
Secondary FlyBase IDs
	FBgn0000468 FBgn0000725 FBgn0003506 FBgn0039693 FBgn0053956 FBpp0084844 FBpp0084845 FBpp0084846 FBtr0085478 FBtr0085479 FBtr0085480
References ( 219 )
Generate a list of	All references relating to this gene ( 219 )
List References by type	Research paper  ( 122 ) Supplementary material  ( 6 ) Review  ( 27 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 38 ) FlyBase analysis  ( 3 ) Letter  ( 1 ) DNA/RNA sequence record  ( 4 ) Stock list  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 ) Book  ( 1 )
Recent research papers ( 15 )
	Horn et al., 2011, Nat. Methods 8(4): 341--346 Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. [FBrf0213352] Weake et al., 2011, Genes Dev. 25(14): 1499--1509 Post-transcription initiation function of the ubiquitous SAGA complex in tissue-specific gene activation. [FBrf0214372] Zhang and Arnosti, 2011, Mol. Cell. Biol. 31(2): 375--384 Conserved catalytic and C-terminal regulatory domains of the C-terminal binding protein corepressor fine-tune the transcriptional response in development. [FBrf0212606] Boyle et al., 2010, Dev. Biol. 346(1): 68--79 Division of labor: Subsets of dorsal-appendage-forming cells control the shape of the entire tube. [FBrf0211761] Freeman et al., 2010, Brain Res. 1326: 15--29 A new genetic model of activity-induced Ras signaling dependent pre-synaptic plasticity in Drosophila. [FBrf0210453] Herranz et al., 2010, Mol. Ecol. 19(19): 4255--4264 Spaceflight-related suboptimal conditions can accentuate the altered gravity response of Drosophila transcriptome. [FBrf0216346] Lee et al., 2010, J. Neurosci. 30(50): 16959--16969 LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction. [FBrf0212570] Lesch et al., 2010, Genetics 186(3): 943--957 A Targeted UAS-RNAi Screen in Drosophila Larvae Identifies Wound Closure Genes Regulating Distinct Cellular Processes. [FBrf0212282] Magwire et al., 2010, PLoS Genet. 6(7): e1001037 Quantitative and molecular genetic analyses of mutations increasing Drosophila life span. [FBrf0211465] Mourikis et al., 2010, BMC Dev. Biol. 10: 107 Modifiers of notch transcriptional activity identified by genome-wide RNAi. [FBrf0212287] Mrinal and Nagaraju, 2010, J. Biol. Chem. 285(31): 24206--24216 Dynamic Repositioning of Dorsal to Two Different {kappa}B Motifs Controls Its Autoregulation during Immune Response in Drosophila. [FBrf0211351] Niwa et al., 2010, Development 137(12): 1991--1999 Non-molting glossy/shroud encodes a short-chain dehydrogenase/reductase that functions in the 'Black Box' of the ecdysteroid biosynthesis pathway. [FBrf0210924] Rallis et al., 2010, Dev. Biol. 339(1): 65--77 Signal strength and signal duration define two distinct aspects of JNK-regulated axon stability. [FBrf0209975] Sekyrova et al., 2010, Development 137(1): 141--150 Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis. [FBrf0209550] Xiong et al., 2010, J. Cell Biol. 191(1): 211--223 Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injury. [FBrf0211939] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...