cytoskeletal protein - actin cross-linker - during oogenesis, phosphorylation of Kelch is critical for the proper morphogenesis of actin during ring canal growth - actin cytoskeletal organization in Drosophila germline ring canals depends on Kelch function in a Cullin-RING E3 ligase.
Please see the JBrowse view of Dmel\kel for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Stop-codon suppression (UGA) postulated; FBrf0057892.
Stop-codon suppression supported by data in FBrf0216884.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.51
6.0 (northern blot)
None of the polypeptides share 100% sequence identity.
160, 76 (kD observed)
787, 688 (aa); 83.5, 76.5 (kD)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\kel using the Feature Mapper tool.
Comment: maternally deposited
Comment: anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage in statu nascendi
Comment: reported as procephalic ectoderm anlage in statu nascendi
The kel transcript is most abundant in ovaries but is also detected in males and ovarectomized females.
kel protein is observed in ring canals starting in germarium region 3. Initially staining is seen in a subset of ring canals. All ring canals are stained by stage 3.
GBrowse - Visual display of RNA-Seq signals
View Dmel\kel in GBrowse 22-53
2-53.2
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
monoclonal
Embryos injected with dsRNA made from templates generated with primers directed against this gene show a broad range of defects at the beginning of cellularisation, including falling of some nuclei from the cortex, and a reduction of nuclear elongation. They also show defects in membrane invagination during cellularisation.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.
kel is essential for the proper organization of actin in ovarian ring canals.
Mutations cause female sterility. Molecular and expression analysis suggests that kelch produces a component of ring canals that regulates the flow of cytoplasm between cells.
Mutations at the kel locus cause defects in midoogenesis.
Schupbach.
"kelch" is German for "goblet", reflecting the shape of eggs formed by mutant females.