FB2022_03, released June 9, 2022

Gene: Dmel\Ki

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General Information
Symbol
Dmel\Ki
Species
D. melanogaster
Name
Kinked
Annotation Symbol
Feature Type
gene
FlyBase ID
FBgn0001307
Gene Model Status
Unannotated
Stock Availability
104 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (0 terms)
Molecular Function (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
    -
    Summaries
    Phenotypic Description (Red Book; Lindsley and Zimm 1992)
    Ki: Kinked
    All bristles and hairs of heterozygote shortened and twisted. Resembles sn. Viability and fertility excellent; classification easy. Homozgyote has more extreme bristle and hair effects. Expression much reduced in flies raised at 18 (Hardy). Ki+ an excellent marker for cuticular clones in Ki/+ heterozygotes. Viability somewhat reduced but fertility near normal. RK1 as heterozygote.
    Gene Model and Products
    Number of Transcripts
    0
    Number of Unique Polypeptides
    0
    Protein Domains (via Pfam)
    Isoform displayed:
    Pfam protein domains
    InterPro name
    classification
    start
    end
    Protein Domains (via SMART)
    Isoform displayed:
    SMART protein domains
    InterPro name
    classification
    start
    end
    Structure New Section
    Comments on Gene Model
    Sequence Ontology: Class of Gene
    gene
    Transcript Data
    Annotated Transcripts
    Additional Transcript Data and Comments
    Reported size (kB)
    Comments
    External Data
    Crossreferences
    Polypeptide Data
    Annotated Polypeptides
    Polypeptides with Identical Sequences

     

    Additional Polypeptide Data and Comments
    Reported size (kDa)
    Comments
    External Data
    Crossreferences
    Linkouts
    Sequences Consistent with the Gene Model
    Nucleotide / Polypeptide Records
      Mapped Features

      Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ki using the Feature Mapper tool.

      External Data
      Crossreferences
      Linkouts
      Expression Data
      Expression Summary Ribbons
      Colored tiles in ribbon indicate that the Fly Cell Atlas project found the gene expressed in that cell type. Darker colors mean that more cells of that cell type express the gene:
       low
      high 
      Colorless tiles indicate that there is no scRNAseq data for the gene in that cell type.
      Colored tiles in ribbon indicate that expression data (RNA and/or protein) has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
      Colored tiles in the ribbon indicate the average RNA expression level of the gene at the indicated stages:
       low
      high 
      as determined by RNA-seq (RPKM) using whole organism samples modENCODE, Brown et al., 2014. For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
      Transcript Expression
      Additional Descriptive Data
      Marker for
       
      Subcellular Localization
      CV Term
      Polypeptide Expression
      Additional Descriptive Data
      Marker for
       
      Subcellular Localization
      CV Term
      Evidence
      References
      Expression Deduced from Reporters
      High-Throughput Expression Data
      Associated Tools

      GBrowse - Visual display of RNA-Seq signals

      View Dmel\Ki in GBrowse 2
      RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
      Bulk Downloads
      RNA-Seq RPKM values for all genes
      Reference
      See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
      Developmental Proteome: Life Cycle
      Developmental Proteome: Embryogenesis
      External Data and Images
      Alleles, Insertions, Transgenic Constructs, and Aberrations
      Classical and Insertion Alleles ( 3 )
      For All Classical and Insertion Alleles Show
       
      Other relevant insertions
      Transgenic Constructs ( 0 )
      For All Alleles Carried on Transgenic Constructs Show
      Transgenic constructs containing/affecting coding region of Ki
      Transgenic constructs containing regulatory region of Ki
      Aberrations (Deficiencies and Duplications) ( 0 )
      Inferred from experimentation ( 0 )
      Inferred from location ( 0 )
        Alleles Representing Disease-Implicated Variants
        Phenotypes
        For more details about a specific phenotype click on the relevant allele symbol.
        Lethality
        Allele
        viable
        Sterility
        Allele
        fertile
        Other Phenotypes
        Allele
        visible | dominant
        visible | dominant | heat sensitive
        Phenotype manifest in
        Allele
        macrochaeta
        microchaeta
        Orthologs
        Downloads
        Download All DIOPT Orthologs
        Human Orthologs (via DIOPT v8.0)
        Homo sapiens (Human) (0)
        No records found.
        Model Organism Orthologs (via DIOPT v8.0)
        Mus musculus (laboratory mouse) (0)
        No records found.
        Rattus norvegicus (Norway rat) (0)
        No records found.
        Xenopus tropicalis (Western clawed frog) (0)
        No records found.
        Danio rerio (Zebrafish) (0)
        No records found.
        Caenorhabditis elegans (Nematode, roundworm) (0)
        No records found.
        Arabidopsis thaliana (thale-cress) (0)
        No records found.
        Saccharomyces cerevisiae (Brewer's yeast) (0)
        No records found.
        Schizosaccharomyces pombe (Fission yeast) (0)
        No records found.
        Other Organism Orthologs (via OrthoDB)
        Paralogs
        Downloads
        Download All DIOPT Paralogs
        Paralogs (via DIOPT v8.0)
        Drosophila melanogaster (Fruit fly) (0)
        No records found.
        Human Disease Associations
        FlyBase Human Disease Model Reports
          Disease Model Summary Ribbon
          Disease Ontology (DO) Annotations
          Models Based on Experimental Evidence ( 0 )
          Allele
          Disease
          Evidence
          References
          Potential Models Based on Orthology ( 0 )
          Human Ortholog
          Disease
          Evidence
          References
          Modifiers Based on Experimental Evidence ( 0 )
          Allele
          Disease
          Interaction
          References
          Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
          Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
          Homo sapiens (Human)
          Gene name
          Score
          OMIM
          OMIM Phenotype
          DO term
          Complementation?
          Transgene?
          Functional Complementation Data
          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
          Interactions
          Summary of Physical Interactions
          esyN Network Diagram
          Interactions Browser
          Summary of Genetic Interactions
          esyN Network Diagram
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          Starting gene(s)
          Interaction type
          Interacting gene(s)
          Reference
          External Data
          Linkouts
          Pathways
          Signaling Pathways (FlyBase)
          Metabolic Pathways
          External Data
          Linkouts
          Genomic Location and Detailed Mapping Data
          Chromosome (arm)
          Recombination map
          3-47.6
          Cytogenetic map
          83D-83E
          Sequence location
          FlyBase Computed Cytological Location
          Cytogenetic map
          Evidence for location
          83D-83E
          Left limit from (method unavailable) (FBrf0034851) Right limit from (method unavailable) (FBrf0034851)
          Experimentally Determined Cytological Location
          Cytogenetic map
          Notes
          References
          Experimentally Determined Recombination Data
          Location

          3-47.6

          Left of (cM)
          Right of (cM)
          (Reuter et al., 1986)
          (Baker, 1980)
          Notes

          Deletions of Ki not obtained, presumably because of close proximity to Tpl.

          (Kaufman, 1978)

          Recovered in newly induced 'C(3R)RM' but not 'C(3L)RM' chromosomes, therefore in 3R.

          (Lütolf, 1971)

          In 3R based on mitotic recombination.

          (Merriam and Garcia-Bellido, 1969)
          Stocks and Reagents
          Stocks (104)
          Genomic Clones (0)
           
            cDNA Clones (0)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
              Other clones
                Drosophila Genomics Resource Center cDNA clones

                For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                    Other clones
                      RNAi and Array Information
                      Linkouts
                      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                      Antibody Information
                      Laboratory Generated Antibodies
                       
                      Commercially Available Antibodies
                       
                      Other Information
                      Relationship to Other Genes
                      Source for database identify of
                      Source for database merge of
                      Additional comments
                      Other Comments

                      Mutants do not exhibit defects in the denticle belt of hairs of the larvae.

                      (Dickinson and Thatcher, 1997)

                      Bsb, Ki and Pr dominant mutations result in extremely shortened bristles.

                      (Abbott and Kaufman, 1986)

                      Mutant alleles are useful as markers in clonal analysis.

                      (Lawrence et al., 1986)

                      Mutant individuals display short and twisted bristles and hairs.

                      (Duncan and Kaufman, 1975)

                      Very closely linked to the triplo-lethal region of 83DE; attempts to revert Ki by deletion unsuccessful (Kaufman, 1978) and Ki frequently deleted simultaneously with Tpl (Roehrdanz and Lucchesi, 1980).

                      Origin and Etymology
                      Discoverer

                      R.F. Grell, Dec. 1957.

                      Etymology
                      Identification
                      External Crossreferences and Linkouts ( 1 )
                      Other crossreferences
                      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                      Synonyms and Secondary IDs (2)
                      Reported As
                      Symbol Synonym
                      Ki
                      (Wang et al., 2009, Siegel et al., 2004)
                      Name Synonyms
                      Kinked
                      (Siegel et al., 2004)
                      Secondary FlyBase IDs
                        Datasets (0)
                        Study focus (0)
                        Experimental Role
                        Project
                        Project Type
                        Title
                        Study result (0)
                        Result
                        Result Type
                        Title
                        References (27)