Gene Dmel\Khc

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\Khc for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Gene model reviewed during 5.50

Low-frequency RNA-Seq exon junction(s) not annotated.

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Khc-RA

FBtr0087184

NM_057242

3718

975

Additional Transcript Data & Comments

Reported size (kB)

4.0 (northern blot)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Khc-PA

FBpp0086328

110.4

975

5.51

NP_476590

AAF58029

Additional Polypeptide Data & Comments

Reported size (kDa)

975 (aa); 110 (kD predicted)

(Yang et al., 1989)

975 (aa)

(Stewart et al., 1993)

34 (kD observed)

(Walker, 1995)

Comments

External Data

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Kinesin, motor domain (IPR001752)

Kinesin, motor region, conserved site (IPR019821)

P-loop containing nucleoside triphosphate hydrolase (IPR027417)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

P17210

UniProtKB/TrEMBL

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Crossreferences

Expression Data

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment:maternally deposited

embryonic stage 4 -- 6

organism

embryonic stage 7 -- 8

organism | ubiquitous

embryonic stage 9 -- 10

organism | ubiquitous

embryonic stage 11 -- 12

organism | ubiquitous

embryonic stage 13 -- 16

organism | ubiquitous

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

head

Additional Descriptive Data

Khc transcripts are detected in RNA isolated from heads.

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

No Assay Recorded

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage & oogenesis

follicle cell

nurse cell

distribution deduced from reporter (Gal4 UAS)

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

photoreceptor cell | apical

enzyme assay or biochemical detection

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage & oogenesis

oocyte

oogenesis & adult stage | female

female germline stem cell

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

organism | ubiquitous

third instar larval stage

PNS glial cell

neuron of embryonic/larval peripheral nervous system

adult stage

lamina neuropil | faint & restricted

epithelial glial cell | faint & restricted

photoreceptor cell R1 | restricted

photoreceptor cell R2 | restricted

photoreceptor cell R3 | restricted

photoreceptor cell R4 | restricted

photoreceptor cell R5 | restricted

photoreceptor cell R6 | restricted

oogenesis

egg chamber | ubiquitous & oogonial cell | ubiquitous

oogenesis stage S8 -- S10A

oocyte | posterior

stage S8 oocyte | anterior & dorsal & stage S9 oocyte | anterior & dorsal & stage S10A oocyte | anterior & dorsal

germarium & oogonial cell

(Hamanaka and Meinertzhagen, 2010, Mosley-Bishop et al., 1999)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood & male -- day 7 of adulthood & male

spermatozoon

(Wasbrough et al., 2010)

day 7 of adulthood -- day 49 of adulthood

adult heart

(Cammarato et al., 2011)

Additional Descriptive Data

Marker for plus ends of microtubules.

Posterior localization within oocyte is not observed.

Khc protein is diffusely distributed in the cytoplasm of all cells in embryos. Before cellularization, staining is most intense in the layer of cytoplasm adjacent to the cortex. After cellularization, staining is most intense in the apical cytoplasm of each somatic cell.

An even distribution of protein was observed throughout the germline cells of the germarium and early egg chambers. Staining was usually more intense in the somatic follicle cells and particularly strong in polar follicle cells.From stage 8 to stage 10A oocytes protein was most concentrated in the posterior pole of the oocyte and a small concentration was also observed in the anterodorsal corner.

This construct is a marker for plus ends of microtubules, and localizes apically in developing facets.

Khc protein is evenly distributed in neurons and glial cells in the peripheral nerves.

Marker for

microtubule

Subcellular Localization (GO Cellular Component)

CV term

References

cytoplasm

inferred from direct assay

kinesin complex

inferred from direct assay

microtubule associated complex

inferred from direct assay

(Hughes et al., 2008)

microtubule plus end

inferred from direct assay

(The modENCODE Consortium, 2010, Graveley et al., 2011)

colocalizes_with
mitochondrion

inferred from direct assay

(Pilling et al., 2006)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

FlyAtlas Anatomical Expression Data

(FlyAtlas-RNA.adult)

(FlyAtlas-RNA.larva)

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	gene max expression
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (>999.999)

Linear, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		259.15
Larval Midgut		247.8
Larval Hindgut		283.9
Larval Malpighian Tubules		205.1
Larval Fat Body		151.7
Larval Salivary Gland		280.2
Larval Trachea		228.45
Larval Carcass		227.45
Adult Head		168
Adult Eye		156.025
Adult Brain		217.3
Adult Thoracic-Abdominal Ganglion		269.1
Adult Crop		235.6
Adult Midgut		264.6
Adult Hindgut		248.8
Adult Malpighian Tubules		261
Adult Fat Body		156.8
Adult Salivary Gland		195.1
Adult Heart		189.05
Adult VirginFemale Spermatheca		153.4
Adult InseminatedFemale Spermatheca		184.5
Adult Ovary		278.3
Adult Testis		70.5
Adult Male Accessory Gland		165.2
Adult Carcass		178.9
Expression Level Scale		None Low Moderate

Linear, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		259.15
Larval Midgut		247.8
Larval Hindgut		283.9
Larval Malpighian Tubules		205.1
Larval Fat Body		151.7
Larval Salivary Gland		280.2
Larval Trachea		228.45
Larval Carcass		227.45
Adult Head		168
Adult Eye		156.025
Adult Brain		217.3
Adult Thoracic-Abdominal Ganglion		269.1
Adult Crop		235.6
Adult Midgut		264.6
Adult Hindgut		248.8
Adult Malpighian Tubules		261
Adult Fat Body		156.8
Adult Salivary Gland		195.1
Adult Heart		189.05
Adult VirginFemale Spermatheca		153.4
Adult InseminatedFemale Spermatheca		184.5
Adult Ovary		278.3
Adult Testis		70.5
Adult Male Accessory Gland		165.2
Adult Carcass		178.9
Expression Level Scale		None Low Moderate High

Linear, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		259.15
Larval Midgut		247.8
Larval Hindgut		283.9
Larval Malpighian Tubules		205.1
Larval Fat Body		151.7
Larval Salivary Gland		280.2
Larval Trachea		228.45
Larval Carcass		227.45
Adult Head		168
Adult Eye		156.025
Adult Brain		217.3
Adult Thoracic-Abdominal Ganglion		269.1
Adult Crop		235.6
Adult Midgut		264.6
Adult Hindgut		248.8
Adult Malpighian Tubules		261
Adult Fat Body		156.8
Adult Salivary Gland		195.1
Adult Heart		189.05
Adult VirginFemale Spermatheca		153.4
Adult InseminatedFemale Spermatheca		184.5
Adult Ovary		278.3
Adult Testis		70.5
Adult Male Accessory Gland		165.2
Adult Carcass		178.9
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		259.15
Larval Midgut		247.8
Larval Hindgut		283.9
Larval Malpighian Tubules		205.1
Larval Fat Body		151.7
Larval Salivary Gland		280.2
Larval Trachea		228.45
Larval Carcass		227.45
Adult Head		168
Adult Eye		156.025
Adult Brain		217.3
Adult Thoracic-Abdominal Ganglion		269.1
Adult Crop		235.6
Adult Midgut		264.6
Adult Hindgut		248.8
Adult Malpighian Tubules		261
Adult Fat Body		156.8
Adult Salivary Gland		195.1
Adult Heart		189.05
Adult VirginFemale Spermatheca		153.4
Adult InseminatedFemale Spermatheca		184.5
Adult Ovary		278.3
Adult Testis		70.5
Adult Male Accessory Gland		165.2
Adult Carcass		178.9
Expression Level Scale		Very high

log, scaled to maximum expression level
Tissue		Expression Level
Larval Central Nervous System		259.15
Larval Midgut		247.8
Larval Hindgut		283.9
Larval Malpighian Tubules		205.1
Larval Fat Body		151.7
Larval Salivary Gland		280.2
Larval Trachea		228.45
Larval Carcass		227.45
Adult Head		168
Adult Eye		156.025
Adult Brain		217.3
Adult Thoracic-Abdominal Ganglion		269.1
Adult Crop		235.6
Adult Midgut		264.6
Adult Hindgut		248.8
Adult Malpighian Tubules		261
Adult Fat Body		156.8
Adult Salivary Gland		195.1
Adult Heart		189.05
Adult VirginFemale Spermatheca		153.4
Adult InseminatedFemale Spermatheca		184.5
Adult Ovary		278.3
Adult Testis		70.5
Adult Male Accessory Gland		165.2
Adult Carcass		178.9
Expression Level Scale		None Low Moderate

log, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		259.15
Larval Midgut		247.8
Larval Hindgut		283.9
Larval Malpighian Tubules		205.1
Larval Fat Body		151.7
Larval Salivary Gland		280.2
Larval Trachea		228.45
Larval Carcass		227.45
Adult Head		168
Adult Eye		156.025
Adult Brain		217.3
Adult Thoracic-Abdominal Ganglion		269.1
Adult Crop		235.6
Adult Midgut		264.6
Adult Hindgut		248.8
Adult Malpighian Tubules		261
Adult Fat Body		156.8
Adult Salivary Gland		195.1
Adult Heart		189.05
Adult VirginFemale Spermatheca		153.4
Adult InseminatedFemale Spermatheca		184.5
Adult Ovary		278.3
Adult Testis		70.5
Adult Male Accessory Gland		165.2
Adult Carcass		178.9
Expression Level Scale		None Low Moderate High

log, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		259.15
Larval Midgut		247.8
Larval Hindgut		283.9
Larval Malpighian Tubules		205.1
Larval Fat Body		151.7
Larval Salivary Gland		280.2
Larval Trachea		228.45
Larval Carcass		227.45
Adult Head		168
Adult Eye		156.025
Adult Brain		217.3
Adult Thoracic-Abdominal Ganglion		269.1
Adult Crop		235.6
Adult Midgut		264.6
Adult Hindgut		248.8
Adult Malpighian Tubules		261
Adult Fat Body		156.8
Adult Salivary Gland		195.1
Adult Heart		189.05
Adult VirginFemale Spermatheca		153.4
Adult InseminatedFemale Spermatheca		184.5
Adult Ovary		278.3
Adult Testis		70.5
Adult Male Accessory Gland		165.2
Adult Carcass		178.9
Expression Level Scale		None Low Moderate High Very high

log, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		259.15
Larval Midgut		247.8
Larval Hindgut		283.9
Larval Malpighian Tubules		205.1
Larval Fat Body		151.7
Larval Salivary Gland		280.2
Larval Trachea		228.45
Larval Carcass		227.45
Adult Head		168
Adult Eye		156.025
Adult Brain		217.3
Adult Thoracic-Abdominal Ganglion		269.1
Adult Crop		235.6
Adult Midgut		264.6
Adult Hindgut		248.8
Adult Malpighian Tubules		261
Adult Fat Body		156.8
Adult Salivary Gland		195.1
Adult Heart		189.05
Adult VirginFemale Spermatheca		153.4
Adult InseminatedFemale Spermatheca		184.5
Adult Ovary		278.3
Adult Testis		70.5
Adult Male Accessory Gland		165.2
Adult Carcass		178.9
Expression Level Scale		None Low Moderate High Very high

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules
Adult Fat Body
Adult Salivary Gland
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level	Tissue	Adult Expression Level
NA	Head	168
NA	Eye	156.025
NA	Brain	217.3
259.15	Central Nervous System	NA
NA	Thoracic-Abdominal Ganglion	269.1
NA	Crop	235.6
247.8	Midgut	264.6
283.9	Hindgut	248.8
205.1	Malpighian Tubules	261
151.7	Fat Body	156.8
280.2	Salivary Gland	195.1
NA	Heart	189.05
228.45	Trachea	NA
NA	VirginFemale Spermatheca	153.4
NA	InseminatedFemale Spermatheca	184.5
NA	Ovary	278.3
NA	Testis	70.5
NA	Male Accessory Gland	165.2
227.45	Carcass	178.9

FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

modENCODE Anatomy RNA-Seq

modENCODE Tissue Expression Data

(modENCODE_mRNA-Seq_tissues)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		40
central nervous system, larvae L3		65
central nervous system, pupae P8		54
head, virgin 1-day female		31
head, virgin 4-day female		25
head, virgin 20-day female		21
head, mated 1-day female		26
head, mated 4-day female		26
head, mated 20-day female		22
head, mated 1-day male		38
head, mated 4-day male		34
head, mated 20-day male		39
salivary gland, larvae L3 wandering		9
salivary gland, white prepupae		40
digestive system, larvae L3 wandering		41
digestive system, 1-day adult		44
digestive system, 4-day adult		39
digestive system, 20-day adult		41
fat body, larvae L3 wandering		18
fat body, white prepupae		32
fat body, pupae P8		31
carcass, larvae L3 wandering		55
carcass, 1-day adult		27
carcass, 4-day adult		28
carcass, 20-day adult		24
ovary, virgin 4-day female		85
ovary, mated 4-day female		79
testis, mated 4-day male		19
accessory gland, mated 4-day male		18
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		(40)
central nervous system, larvae L3		(65)
central nervous system, pupae P8		(54)
head, virgin 1-day female		(31)
head, virgin 4-day female		25
head, virgin 20-day female		21
head, mated 1-day female		26
head, mated 4-day female		26
head, mated 20-day female		22
head, mated 1-day male		(38)
head, mated 4-day male		(34)
head, mated 20-day male		(39)
salivary gland, larvae L3 wandering		9
salivary gland, white prepupae		(40)
digestive system, larvae L3 wandering		(41)
digestive system, 1-day adult		(44)
digestive system, 4-day adult		(39)
digestive system, 20-day adult		(41)
fat body, larvae L3 wandering		18
fat body, white prepupae		(32)
fat body, pupae P8		(31)
carcass, larvae L3 wandering		(55)
carcass, 1-day adult		(27)
carcass, 4-day adult		(28)
carcass, 20-day adult		24
ovary, virgin 4-day female		(85)
ovary, mated 4-day female		(79)
testis, mated 4-day male		19
accessory gland, mated 4-day male		18
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		40
central nervous system, larvae L3		65
central nervous system, pupae P8		54
head, virgin 1-day female		31
head, virgin 4-day female		25
head, virgin 20-day female		21
head, mated 1-day female		26
head, mated 4-day female		26
head, mated 20-day female		22
head, mated 1-day male		38
head, mated 4-day male		34
head, mated 20-day male		39
salivary gland, larvae L3 wandering		9
salivary gland, white prepupae		40
digestive system, larvae L3 wandering		41
digestive system, 1-day adult		44
digestive system, 4-day adult		39
digestive system, 20-day adult		41
fat body, larvae L3 wandering		18
fat body, white prepupae		32
fat body, pupae P8		31
carcass, larvae L3 wandering		55
carcass, 1-day adult		27
carcass, 4-day adult		28
carcass, 20-day adult		24
ovary, virgin 4-day female		85
ovary, mated 4-day female		79
testis, mated 4-day male		19
accessory gland, mated 4-day male		18
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		40
central nervous system, larvae L3		65
central nervous system, pupae P8		54
head, virgin 1-day female		31
head, virgin 4-day female		25
head, virgin 20-day female		21
head, mated 1-day female		26
head, mated 4-day female		26
head, mated 20-day female		22
head, mated 1-day male		38
head, mated 4-day male		34
head, mated 20-day male		39
salivary gland, larvae L3 wandering		9
salivary gland, white prepupae		40
digestive system, larvae L3 wandering		41
digestive system, 1-day adult		44
digestive system, 4-day adult		39
digestive system, 20-day adult		41
fat body, larvae L3 wandering		18
fat body, white prepupae		32
fat body, pupae P8		31
carcass, larvae L3 wandering		55
carcass, 1-day adult		27
carcass, 4-day adult		28
carcass, 20-day adult		24
ovary, virgin 4-day female		85
ovary, mated 4-day female		79
testis, mated 4-day male		19
accessory gland, mated 4-day male		18
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Tissue		Expression Level
imaginal disc, larvae L3 wandering		40
central nervous system, larvae L3		65
central nervous system, pupae P8		54
head, virgin 1-day female		31
head, virgin 4-day female		25
head, virgin 20-day female		21
head, mated 1-day female		26
head, mated 4-day female		26
head, mated 20-day female		22
head, mated 1-day male		38
head, mated 4-day male		34
head, mated 20-day male		39
salivary gland, larvae L3 wandering		9
salivary gland, white prepupae		40
digestive system, larvae L3 wandering		41
digestive system, 1-day adult		44
digestive system, 4-day adult		39
digestive system, 20-day adult		41
fat body, larvae L3 wandering		18
fat body, white prepupae		32
fat body, pupae P8		31
carcass, larvae L3 wandering		55
carcass, 1-day adult		27
carcass, 4-day adult		28
carcass, 20-day adult		24
ovary, virgin 4-day female		85
ovary, mated 4-day female		79
testis, mated 4-day male		19
accessory gland, mated 4-day male		18
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		(40)
central nervous system, larvae L3		(65)
central nervous system, pupae P8		(54)
head, virgin 1-day female		31
head, virgin 4-day female		25
head, virgin 20-day female		21
head, mated 1-day female		26
head, mated 4-day female		26
head, mated 20-day female		22
head, mated 1-day male		(38)
head, mated 4-day male		(34)
head, mated 20-day male		(39)
salivary gland, larvae L3 wandering		9
salivary gland, white prepupae		(40)
digestive system, larvae L3 wandering		(41)
digestive system, 1-day adult		(44)
digestive system, 4-day adult		(39)
digestive system, 20-day adult		(41)
fat body, larvae L3 wandering		18
fat body, white prepupae		32
fat body, pupae P8		31
carcass, larvae L3 wandering		(55)
carcass, 1-day adult		27
carcass, 4-day adult		28
carcass, 20-day adult		24
ovary, virgin 4-day female		(85)
ovary, mated 4-day female		(79)
testis, mated 4-day male		19
accessory gland, mated 4-day male		18
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		40
central nervous system, larvae L3		65
central nervous system, pupae P8		54
head, virgin 1-day female		31
head, virgin 4-day female		25
head, virgin 20-day female		21
head, mated 1-day female		26
head, mated 4-day female		26
head, mated 20-day female		22
head, mated 1-day male		38
head, mated 4-day male		34
head, mated 20-day male		39
salivary gland, larvae L3 wandering		9
salivary gland, white prepupae		40
digestive system, larvae L3 wandering		41
digestive system, 1-day adult		44
digestive system, 4-day adult		39
digestive system, 20-day adult		41
fat body, larvae L3 wandering		18
fat body, white prepupae		32
fat body, pupae P8		31
carcass, larvae L3 wandering		55
carcass, 1-day adult		27
carcass, 4-day adult		28
carcass, 20-day adult		24
ovary, virgin 4-day female		85
ovary, mated 4-day female		79
testis, mated 4-day male		19
accessory gland, mated 4-day male		18
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Tissue		Expression Level
imaginal disc, larvae L3 wandering		40
central nervous system, larvae L3		65
central nervous system, pupae P8		54
head, virgin 1-day female		31
head, virgin 4-day female		25
head, virgin 20-day female		21
head, mated 1-day female		26
head, mated 4-day female		26
head, mated 20-day female		22
head, mated 1-day male		38
head, mated 4-day male		34
head, mated 20-day male		39
salivary gland, larvae L3 wandering		9
salivary gland, white prepupae		40
digestive system, larvae L3 wandering		41
digestive system, 1-day adult		44
digestive system, 4-day adult		39
digestive system, 20-day adult		41
fat body, larvae L3 wandering		18
fat body, white prepupae		32
fat body, pupae P8		31
carcass, larvae L3 wandering		55
carcass, 1-day adult		27
carcass, 4-day adult		28
carcass, 20-day adult		24
ovary, virgin 4-day female		85
ovary, mated 4-day female		79
testis, mated 4-day male		19
accessory gland, mated 4-day male		18
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Tissue		Expression Level
imaginal disc, larvae L3 wandering
central nervous system, larvae L3
central nervous system, pupae P8
head, virgin 1-day female
head, virgin 4-day female
head, virgin 20-day female
head, mated 1-day female
head, mated 4-day female
head, mated 20-day female
head, mated 1-day male
head, mated 4-day male
head, mated 20-day male
salivary gland, larvae L3 wandering
salivary gland, white prepupae
digestive system, larvae L3 wandering
digestive system, 1-day adult
digestive system, 4-day adult
digestive system, 20-day adult
fat body, larvae L3 wandering
fat body, white prepupae
fat body, pupae P8
carcass, larvae L3 wandering
carcass, 1-day adult
carcass, 4-day adult
carcass, 20-day adult
ovary, virgin 4-day female
ovary, mated 4-day female
testis, mated 4-day male
accessory gland, mated 4-day male

modENCODE Development RNA-Seq

modENCODE Temporal Expression Data

(modENCODE_mRNA-Seq_U)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, at stages throughout the pupal period, in adult female stages.
[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		115
embryo 02-04hr		63
embryo 04-06hr		29
embryo 06-08hr		41
embryo 08-10hr		52
embryo 10-12hr		67
embryo 12-14hr		61
embryo 14-16hr		73
embryo 16-18hr		59
embryo 18-20hr		51
embryo 20-22hr		54
embryo 22-24hr		50
larva L1		52
larva L2		64
larva L3 12hr old		47
larva L3 puffstage 1-2		36
larva L3 puffstage 3-6		46
larva L3 puffstage 7-9		50
white prepupae new		57
white prepupae 12hr		60
white prepupae 24hr		65
pupae 2d postWPP		53
pupae 3d postWPP		42
pupae 4d postWPP		49
adult male 01day		39
adult male 05day		36
adult male 30day		38
adult female 01day		56
adult female 05day		73
adult female 30day		72
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(115)
embryo 02-04hr		(63)
embryo 04-06hr		(29)
embryo 06-08hr		(41)
embryo 08-10hr		(52)
embryo 10-12hr		(67)
embryo 12-14hr		(61)
embryo 14-16hr		(73)
embryo 16-18hr		(59)
embryo 18-20hr		(51)
embryo 20-22hr		(54)
embryo 22-24hr		(50)
larva L1		(52)
larva L2		(64)
larva L3 12hr old		(47)
larva L3 puffstage 1-2		(36)
larva L3 puffstage 3-6		(46)
larva L3 puffstage 7-9		(50)
white prepupae new		(57)
white prepupae 12hr		(60)
white prepupae 24hr		(65)
pupae 2d postWPP		(53)
pupae 3d postWPP		(42)
pupae 4d postWPP		(49)
adult male 01day		(39)
adult male 05day		(36)
adult male 30day		(38)
adult female 01day		(56)
adult female 05day		(73)
adult female 30day		(72)
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		(115)
embryo 02-04hr		63
embryo 04-06hr		29
embryo 06-08hr		41
embryo 08-10hr		52
embryo 10-12hr		67
embryo 12-14hr		61
embryo 14-16hr		73
embryo 16-18hr		59
embryo 18-20hr		51
embryo 20-22hr		54
embryo 22-24hr		50
larva L1		52
larva L2		64
larva L3 12hr old		47
larva L3 puffstage 1-2		36
larva L3 puffstage 3-6		46
larva L3 puffstage 7-9		50
white prepupae new		57
white prepupae 12hr		60
white prepupae 24hr		65
pupae 2d postWPP		53
pupae 3d postWPP		42
pupae 4d postWPP		49
adult male 01day		39
adult male 05day		36
adult male 30day		38
adult female 01day		56
adult female 05day		73
adult female 30day		72
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		115
embryo 02-04hr		63
embryo 04-06hr		29
embryo 06-08hr		41
embryo 08-10hr		52
embryo 10-12hr		67
embryo 12-14hr		61
embryo 14-16hr		73
embryo 16-18hr		59
embryo 18-20hr		51
embryo 20-22hr		54
embryo 22-24hr		50
larva L1		52
larva L2		64
larva L3 12hr old		47
larva L3 puffstage 1-2		36
larva L3 puffstage 3-6		46
larva L3 puffstage 7-9		50
white prepupae new		57
white prepupae 12hr		60
white prepupae 24hr		65
pupae 2d postWPP		53
pupae 3d postWPP		42
pupae 4d postWPP		49
adult male 01day		39
adult male 05day		36
adult male 30day		38
adult female 01day		56
adult female 05day		73
adult female 30day		72
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Developmental Stage		Expression Level
embryo 00-02hr		115
embryo 02-04hr		63
embryo 04-06hr		29
embryo 06-08hr		41
embryo 08-10hr		52
embryo 10-12hr		67
embryo 12-14hr		61
embryo 14-16hr		73
embryo 16-18hr		59
embryo 18-20hr		51
embryo 20-22hr		54
embryo 22-24hr		50
larva L1		52
larva L2		64
larva L3 12hr old		47
larva L3 puffstage 1-2		36
larva L3 puffstage 3-6		46
larva L3 puffstage 7-9		50
white prepupae new		57
white prepupae 12hr		60
white prepupae 24hr		65
pupae 2d postWPP		53
pupae 3d postWPP		42
pupae 4d postWPP		49
adult male 01day		39
adult male 05day		36
adult male 30day		38
adult female 01day		56
adult female 05day		73
adult female 30day		72
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		(115)
embryo 02-04hr		(63)
embryo 04-06hr		29
embryo 06-08hr		(41)
embryo 08-10hr		(52)
embryo 10-12hr		(67)
embryo 12-14hr		(61)
embryo 14-16hr		(73)
embryo 16-18hr		(59)
embryo 18-20hr		(51)
embryo 20-22hr		(54)
embryo 22-24hr		(50)
larva L1		(52)
larva L2		(64)
larva L3 12hr old		(47)
larva L3 puffstage 1-2		(36)
larva L3 puffstage 3-6		(46)
larva L3 puffstage 7-9		(50)
white prepupae new		(57)
white prepupae 12hr		(60)
white prepupae 24hr		(65)
pupae 2d postWPP		(53)
pupae 3d postWPP		(42)
pupae 4d postWPP		(49)
adult male 01day		(39)
adult male 05day		(36)
adult male 30day		(38)
adult female 01day		(56)
adult female 05day		(73)
adult female 30day		(72)
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		115
embryo 02-04hr		63
embryo 04-06hr		29
embryo 06-08hr		41
embryo 08-10hr		52
embryo 10-12hr		67
embryo 12-14hr		61
embryo 14-16hr		73
embryo 16-18hr		59
embryo 18-20hr		51
embryo 20-22hr		54
embryo 22-24hr		50
larva L1		52
larva L2		64
larva L3 12hr old		47
larva L3 puffstage 1-2		36
larva L3 puffstage 3-6		46
larva L3 puffstage 7-9		50
white prepupae new		57
white prepupae 12hr		60
white prepupae 24hr		65
pupae 2d postWPP		53
pupae 3d postWPP		42
pupae 4d postWPP		49
adult male 01day		39
adult male 05day		36
adult male 30day		38
adult female 01day		56
adult female 05day		73
adult female 30day		72
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		115
embryo 02-04hr		63
embryo 04-06hr		29
embryo 06-08hr		41
embryo 08-10hr		52
embryo 10-12hr		67
embryo 12-14hr		61
embryo 14-16hr		73
embryo 16-18hr		59
embryo 18-20hr		51
embryo 20-22hr		54
embryo 22-24hr		50
larva L1		52
larva L2		64
larva L3 12hr old		47
larva L3 puffstage 1-2		36
larva L3 puffstage 3-6		46
larva L3 puffstage 7-9		50
white prepupae new		57
white prepupae 12hr		60
white prepupae 24hr		65
pupae 2d postWPP		53
pupae 3d postWPP		42
pupae 4d postWPP		49
adult male 01day		39
adult male 05day		36
adult male 30day		38
adult female 01day		56
adult female 05day		73
adult female 30day		72
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

modENCODE Temporal Expression Data (Graveley et al., 2011)

modENCODE Cell Lines RNA-Seq

modENCODE Cell Line Expression Data

(modENCODE_mRNA-Seq_cell.A)

(modENCODE_mRNA-Seq_cell.B)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		109
Schneider line 2 Sg4		59
embryonic 1182-4H		97
embryonic GM2		91
embryonic Kc167		27
embryonic S1		81
embryonic S3		42
leg disc CME L1		78
wing disc CME-W2		29
wing disc ML-DmD8		47
wing disc ML-DmD9		86
wing disc ML-DmD16-c3		89
wing disc ML-DmD21		54
wing disc ML-DmD32		57
haltere disc ML-DmD17-c3		65
eye-antennal disc ML-DmD11		56
antennal disc ML-DmD20-c5		78
mixed discs ML-DmD4-c1		70
CNS ML-DmBG1-c1		68
CNS ML-DmBG2-c2		51
tumorous blood cells mbn2		56
ovary fGS/OSS		148
ovary OSC		71
ovary OSS		53
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		(109)
Schneider line 2 Sg4		(59)
embryonic 1182-4H		(97)
embryonic GM2		(91)
embryonic Kc167		(27)
embryonic S1		(81)
embryonic S3		(42)
leg disc CME L1		(78)
wing disc CME-W2		(29)
wing disc ML-DmD8		(47)
wing disc ML-DmD9		(86)
wing disc ML-DmD16-c3		(89)
wing disc ML-DmD21		(54)
wing disc ML-DmD32		(57)
haltere disc ML-DmD17-c3		(65)
eye-antennal disc ML-DmD11		(56)
antennal disc ML-DmD20-c5		(78)
mixed discs ML-DmD4-c1		(70)
CNS ML-DmBG1-c1		(68)
CNS ML-DmBG2-c2		(51)
tumorous blood cells mbn2		(56)
ovary fGS/OSS		(148)
ovary OSC		(71)
ovary OSS		(53)
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		(109)
Schneider line 2 Sg4		59
embryonic 1182-4H		97
embryonic GM2		91
embryonic Kc167		27
embryonic S1		81
embryonic S3		42
leg disc CME L1		78
wing disc CME-W2		29
wing disc ML-DmD8		47
wing disc ML-DmD9		86
wing disc ML-DmD16-c3		89
wing disc ML-DmD21		54
wing disc ML-DmD32		57
haltere disc ML-DmD17-c3		65
eye-antennal disc ML-DmD11		56
antennal disc ML-DmD20-c5		78
mixed discs ML-DmD4-c1		70
CNS ML-DmBG1-c1		68
CNS ML-DmBG2-c2		51
tumorous blood cells mbn2		56
ovary fGS/OSS		(148)
ovary OSC		71
ovary OSS		53
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		109
Schneider line 2 Sg4		59
embryonic 1182-4H		97
embryonic GM2		91
embryonic Kc167		27
embryonic S1		81
embryonic S3		42
leg disc CME L1		78
wing disc CME-W2		29
wing disc ML-DmD8		47
wing disc ML-DmD9		86
wing disc ML-DmD16-c3		89
wing disc ML-DmD21		54
wing disc ML-DmD32		57
haltere disc ML-DmD17-c3		65
eye-antennal disc ML-DmD11		56
antennal disc ML-DmD20-c5		78
mixed discs ML-DmD4-c1		70
CNS ML-DmBG1-c1		68
CNS ML-DmBG2-c2		51
tumorous blood cells mbn2		56
ovary fGS/OSS		148
ovary OSC		71
ovary OSS		53
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Cell Line		Expression Level
Schneider line 2 S2R+		109
Schneider line 2 Sg4		59
embryonic 1182-4H		97
embryonic GM2		91
embryonic Kc167		27
embryonic S1		81
embryonic S3		42
leg disc CME L1		78
wing disc CME-W2		29
wing disc ML-DmD8		47
wing disc ML-DmD9		86
wing disc ML-DmD16-c3		89
wing disc ML-DmD21		54
wing disc ML-DmD32		57
haltere disc ML-DmD17-c3		65
eye-antennal disc ML-DmD11		56
antennal disc ML-DmD20-c5		78
mixed discs ML-DmD4-c1		70
CNS ML-DmBG1-c1		68
CNS ML-DmBG2-c2		51
tumorous blood cells mbn2		56
ovary fGS/OSS		148
ovary OSC		71
ovary OSS		53
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Cell Line		Expression Level
Schneider line 2 S2R+		(109)
Schneider line 2 Sg4		(59)
embryonic 1182-4H		(97)
embryonic GM2		(91)
embryonic Kc167		27
embryonic S1		(81)
embryonic S3		(42)
leg disc CME L1		(78)
wing disc CME-W2		29
wing disc ML-DmD8		(47)
wing disc ML-DmD9		(86)
wing disc ML-DmD16-c3		(89)
wing disc ML-DmD21		(54)
wing disc ML-DmD32		(57)
haltere disc ML-DmD17-c3		(65)
eye-antennal disc ML-DmD11		(56)
antennal disc ML-DmD20-c5		(78)
mixed discs ML-DmD4-c1		(70)
CNS ML-DmBG1-c1		(68)
CNS ML-DmBG2-c2		(51)
tumorous blood cells mbn2		(56)
ovary fGS/OSS		(148)
ovary OSC		(71)
ovary OSS		(53)
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Cell Line		Expression Level
Schneider line 2 S2R+		109
Schneider line 2 Sg4		59
embryonic 1182-4H		97
embryonic GM2		91
embryonic Kc167		27
embryonic S1		81
embryonic S3		42
leg disc CME L1		78
wing disc CME-W2		29
wing disc ML-DmD8		47
wing disc ML-DmD9		86
wing disc ML-DmD16-c3		89
wing disc ML-DmD21		54
wing disc ML-DmD32		57
haltere disc ML-DmD17-c3		65
eye-antennal disc ML-DmD11		56
antennal disc ML-DmD20-c5		78
mixed discs ML-DmD4-c1		70
CNS ML-DmBG1-c1		68
CNS ML-DmBG2-c2		51
tumorous blood cells mbn2		56
ovary fGS/OSS		(148)
ovary OSC		71
ovary OSS		53
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Cell Line		Expression Level
Schneider line 2 S2R+		109
Schneider line 2 Sg4		59
embryonic 1182-4H		97
embryonic GM2		91
embryonic Kc167		27
embryonic S1		81
embryonic S3		42
leg disc CME L1		78
wing disc CME-W2		29
wing disc ML-DmD8		47
wing disc ML-DmD9		86
wing disc ML-DmD16-c3		89
wing disc ML-DmD21		54
wing disc ML-DmD32		57
haltere disc ML-DmD17-c3		65
eye-antennal disc ML-DmD11		56
antennal disc ML-DmD20-c5		78
mixed discs ML-DmD4-c1		70
CNS ML-DmBG1-c1		68
CNS ML-DmBG2-c2		51
tumorous blood cells mbn2		56
ovary fGS/OSS		148
ovary OSC		71
ovary OSS		53
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Cell Line		Expression Level
Schneider line 2 S2R+
Schneider line 2 Sg4
embryonic 1182-4H
embryonic GM2
embryonic Kc167
embryonic S1
embryonic S3
leg disc CME L1
wing disc CME-W2
wing disc ML-DmD8
wing disc ML-DmD9
wing disc ML-DmD16-c3
wing disc ML-DmD21
wing disc ML-DmD32
haltere disc ML-DmD17-c3
eye-antennal disc ML-DmD11
antennal disc ML-DmD20-c5
mixed discs ML-DmD4-c1
CNS ML-DmBG1-c1
CNS ML-DmBG2-c2
tumorous blood cells mbn2
ovary fGS/OSS
ovary OSC
ovary OSS

modENCODE Treatments RNA-Seq

modENCODE Treatment Expression Data

(modENCODE_mRNA-Seq_treatments)

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	gene max expression
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

[download data (TSV)]

Guide to modENCODE expression level colors
	No/Extremely low expression (0 - 0)
	Very low expression (1 - 3)
	Low expression (4 - 10)
	Moderate expression (11 - 25)
	Moderately high expression (26 - 50)
	High expression (51 - 100)
	Very high expression (101 - 1000)
	Extremely high expression (>1000)

Linear, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		41
cold shock, 4-day adult		32
heat shock, 4-day adult		41
Cadmium 50 mM 6 hrs, larvae L3		26
Cadmium 50 mM 12 hrs, larvae L3		16
Cadmium 50 mM 48 hrs, 4-day adult		44
Cadmium 100 mM 48 hrs, 4-day adult		66
Copper 0.5 mM 12 hrs, larvae L3		36
Copper 15 mM 48 hrs, 4-day adult		38
Zinc 5 mM 12 hrs, larvae L3		26
Zinc 4.5 mM 48 hrs, 4-day adult		29
Ethanol 2.5% 3 hrs, larvae L3		72
Ethanol 5% 3 hrs, larvae L3		26
Ethanol 10% 3 hrs, larvae L3		28
Caffeine 1.5 mg/ml 4 hrs, larvae L3		17
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		58
Caffeine 25 mg/ml 48 hrs, 4-day adult		37
Paraquat 5 mM 48 hrs, 4-day adult		52
Paraquat 10 mM 48 hrs, 4-day adult		55
Rotenone 2 μg 12 hrs, larvae L3		23
Rotenone 8 μg 12 hrs, larvae L3		26
Expression Level Scale		Very low Low Moderate Moderately high High

Linear, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		(41)
cold shock, 4-day adult		(32)
heat shock, 4-day adult		(41)
Cadmium 50 mM 6 hrs, larvae L3		26
Cadmium 50 mM 12 hrs, larvae L3		16
Cadmium 50 mM 48 hrs, 4-day adult		(44)
Cadmium 100 mM 48 hrs, 4-day adult		(66)
Copper 0.5 mM 12 hrs, larvae L3		(36)
Copper 15 mM 48 hrs, 4-day adult		(38)
Zinc 5 mM 12 hrs, larvae L3		26
Zinc 4.5 mM 48 hrs, 4-day adult		(29)
Ethanol 2.5% 3 hrs, larvae L3		(72)
Ethanol 5% 3 hrs, larvae L3		26
Ethanol 10% 3 hrs, larvae L3		(28)
Caffeine 1.5 mg/ml 4 hrs, larvae L3		17
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		(58)
Caffeine 25 mg/ml 48 hrs, 4-day adult		(37)
Paraquat 5 mM 48 hrs, 4-day adult		(52)
Paraquat 10 mM 48 hrs, 4-day adult		(55)
Rotenone 2 μg 12 hrs, larvae L3		23
Rotenone 8 μg 12 hrs, larvae L3		26
Expression Level Scale		Very low Low Moderate Moderately high

Linear, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		41
cold shock, 4-day adult		32
heat shock, 4-day adult		41
Cadmium 50 mM 6 hrs, larvae L3		26
Cadmium 50 mM 12 hrs, larvae L3		16
Cadmium 50 mM 48 hrs, 4-day adult		44
Cadmium 100 mM 48 hrs, 4-day adult		66
Copper 0.5 mM 12 hrs, larvae L3		36
Copper 15 mM 48 hrs, 4-day adult		38
Zinc 5 mM 12 hrs, larvae L3		26
Zinc 4.5 mM 48 hrs, 4-day adult		29
Ethanol 2.5% 3 hrs, larvae L3		72
Ethanol 5% 3 hrs, larvae L3		26
Ethanol 10% 3 hrs, larvae L3		28
Caffeine 1.5 mg/ml 4 hrs, larvae L3		17
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		58
Caffeine 25 mg/ml 48 hrs, 4-day adult		37
Paraquat 5 mM 48 hrs, 4-day adult		52
Paraquat 10 mM 48 hrs, 4-day adult		55
Rotenone 2 μg 12 hrs, larvae L3		23
Rotenone 8 μg 12 hrs, larvae L3		26
Expression Level Scale		Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		41
cold shock, 4-day adult		32
heat shock, 4-day adult		41
Cadmium 50 mM 6 hrs, larvae L3		26
Cadmium 50 mM 12 hrs, larvae L3		16
Cadmium 50 mM 48 hrs, 4-day adult		44
Cadmium 100 mM 48 hrs, 4-day adult		66
Copper 0.5 mM 12 hrs, larvae L3		36
Copper 15 mM 48 hrs, 4-day adult		38
Zinc 5 mM 12 hrs, larvae L3		26
Zinc 4.5 mM 48 hrs, 4-day adult		29
Ethanol 2.5% 3 hrs, larvae L3		72
Ethanol 5% 3 hrs, larvae L3		26
Ethanol 10% 3 hrs, larvae L3		28
Caffeine 1.5 mg/ml 4 hrs, larvae L3		17
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		58
Caffeine 25 mg/ml 48 hrs, 4-day adult		37
Paraquat 5 mM 48 hrs, 4-day adult		52
Paraquat 10 mM 48 hrs, 4-day adult		55
Rotenone 2 μg 12 hrs, larvae L3		23
Rotenone 8 μg 12 hrs, larvae L3		26
Expression Level Scale		Extremely high

log, scaled to maximum expression level
Treatment		Expression Level
extended cold, 4-day adult		41
cold shock, 4-day adult		32
heat shock, 4-day adult		41
Cadmium 50 mM 6 hrs, larvae L3		26
Cadmium 50 mM 12 hrs, larvae L3		16
Cadmium 50 mM 48 hrs, 4-day adult		44
Cadmium 100 mM 48 hrs, 4-day adult		66
Copper 0.5 mM 12 hrs, larvae L3		36
Copper 15 mM 48 hrs, 4-day adult		38
Zinc 5 mM 12 hrs, larvae L3		26
Zinc 4.5 mM 48 hrs, 4-day adult		29
Ethanol 2.5% 3 hrs, larvae L3		72
Ethanol 5% 3 hrs, larvae L3		26
Ethanol 10% 3 hrs, larvae L3		28
Caffeine 1.5 mg/ml 4 hrs, larvae L3		17
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		58
Caffeine 25 mg/ml 48 hrs, 4-day adult		37
Paraquat 5 mM 48 hrs, 4-day adult		52
Paraquat 10 mM 48 hrs, 4-day adult		55
Rotenone 2 μg 12 hrs, larvae L3		23
Rotenone 8 μg 12 hrs, larvae L3		26
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Moderate expression
Treatment		Expression Level
extended cold, 4-day adult		(41)
cold shock, 4-day adult		32
heat shock, 4-day adult		(41)
Cadmium 50 mM 6 hrs, larvae L3		26
Cadmium 50 mM 12 hrs, larvae L3		16
Cadmium 50 mM 48 hrs, 4-day adult		(44)
Cadmium 100 mM 48 hrs, 4-day adult		(66)
Copper 0.5 mM 12 hrs, larvae L3		(36)
Copper 15 mM 48 hrs, 4-day adult		(38)
Zinc 5 mM 12 hrs, larvae L3		26
Zinc 4.5 mM 48 hrs, 4-day adult		29
Ethanol 2.5% 3 hrs, larvae L3		(72)
Ethanol 5% 3 hrs, larvae L3		26
Ethanol 10% 3 hrs, larvae L3		28
Caffeine 1.5 mg/ml 4 hrs, larvae L3		17
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		(58)
Caffeine 25 mg/ml 48 hrs, 4-day adult		(37)
Paraquat 5 mM 48 hrs, 4-day adult		(52)
Paraquat 10 mM 48 hrs, 4-day adult		(55)
Rotenone 2 μg 12 hrs, larvae L3		23
Rotenone 8 μg 12 hrs, larvae L3		26
Expression Level Scale		Very low Low Moderate Moderately high

log, scaled to High expression
Treatment		Expression Level
extended cold, 4-day adult		41
cold shock, 4-day adult		32
heat shock, 4-day adult		41
Cadmium 50 mM 6 hrs, larvae L3		26
Cadmium 50 mM 12 hrs, larvae L3		16
Cadmium 50 mM 48 hrs, 4-day adult		44
Cadmium 100 mM 48 hrs, 4-day adult		66
Copper 0.5 mM 12 hrs, larvae L3		36
Copper 15 mM 48 hrs, 4-day adult		38
Zinc 5 mM 12 hrs, larvae L3		26
Zinc 4.5 mM 48 hrs, 4-day adult		29
Ethanol 2.5% 3 hrs, larvae L3		72
Ethanol 5% 3 hrs, larvae L3		26
Ethanol 10% 3 hrs, larvae L3		28
Caffeine 1.5 mg/ml 4 hrs, larvae L3		17
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		58
Caffeine 25 mg/ml 48 hrs, 4-day adult		37
Paraquat 5 mM 48 hrs, 4-day adult		52
Paraquat 10 mM 48 hrs, 4-day adult		55
Rotenone 2 μg 12 hrs, larvae L3		23
Rotenone 8 μg 12 hrs, larvae L3		26
Expression Level Scale		Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Treatment		Expression Level
extended cold, 4-day adult		41
cold shock, 4-day adult		32
heat shock, 4-day adult		41
Cadmium 50 mM 6 hrs, larvae L3		26
Cadmium 50 mM 12 hrs, larvae L3		16
Cadmium 50 mM 48 hrs, 4-day adult		44
Cadmium 100 mM 48 hrs, 4-day adult		66
Copper 0.5 mM 12 hrs, larvae L3		36
Copper 15 mM 48 hrs, 4-day adult		38
Zinc 5 mM 12 hrs, larvae L3		26
Zinc 4.5 mM 48 hrs, 4-day adult		29
Ethanol 2.5% 3 hrs, larvae L3		72
Ethanol 5% 3 hrs, larvae L3		26
Ethanol 10% 3 hrs, larvae L3		28
Caffeine 1.5 mg/ml 4 hrs, larvae L3		17
Caffeine 2.5 mg/ml 48 hrs, 4-day adult		58
Caffeine 25 mg/ml 48 hrs, 4-day adult		37
Paraquat 5 mM 48 hrs, 4-day adult		52
Paraquat 10 mM 48 hrs, 4-day adult		55
Rotenone 2 μg 12 hrs, larvae L3		23
Rotenone 8 μg 12 hrs, larvae L3		26
Expression Level Scale		Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Treatment		Expression Level
extended cold, 4-day adult
cold shock, 4-day adult
heat shock, 4-day adult
Cadmium 50 mM 6 hrs, larvae L3
Cadmium 50 mM 12 hrs, larvae L3
Cadmium 50 mM 48 hrs, 4-day adult
Cadmium 100 mM 48 hrs, 4-day adult
Copper 0.5 mM 12 hrs, larvae L3
Copper 15 mM 48 hrs, 4-day adult
Zinc 5 mM 12 hrs, larvae L3
Zinc 4.5 mM 48 hrs, 4-day adult
Ethanol 2.5% 3 hrs, larvae L3
Ethanol 5% 3 hrs, larvae L3
Ethanol 10% 3 hrs, larvae L3
Caffeine 1.5 mg/ml 4 hrs, larvae L3
Caffeine 2.5 mg/ml 48 hrs, 4-day adult
Caffeine 25 mg/ml 48 hrs, 4-day adult
Paraquat 5 mM 48 hrs, 4-day adult
Paraquat 10 mM 48 hrs, 4-day adult
Rotenone 2 μg 12 hrs, larvae L3
Rotenone 8 μg 12 hrs, larvae L3

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

External Data & Images

partially lethal - majority die | embryonic stage

BDGP expression data

•

SD02406

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0001308

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG7765-RA

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

lethal

lethal, with Scer\GAL4^elav-C155

Khc^{248-2134.Scer\UAS.T:Avic\GFP-EGFP}

lethal, with Scer\GAL4^elav-C155, Scer\GAL4^repo.PL, Scer\GAL4^repo

Khc^GD12278

lethal (with Df(2R)Jp6)

lethal (with Khc⁶)

Khc²⁷

lethal (with Khc²²)

Khc²⁷

lethal (with Khc²⁷)

lethal (with Khc⁷⁴)

Khc²⁷

lethal (with Khc^pgs1)

Khc²⁷

lethal | embryonic stage

Khc²⁷

lethal | embryonic stage | germline clone

Khc²⁷

lethal | heat sensitive

Khc^1ts

lethal | larval stage | heat sensitive, with Scer\GAL4^D42

Khc^{N262S.Scer\UAS}

lethal | pupal stage (with Df(2R)Jp6)

lethal | pupal stage (with Khc¹⁷)

Khc²⁷

lethal | pupal stage (with Khc²⁷)

Khc¹⁷

lethal | recessive

lethal | second instar larval stage (with Df(2R)Jp6)

lethal | third instar larval stage (with Df(2R)Jp6)

lethal | third instar larval stage (with Df(2R)Jp7)

Khc⁷⁴

lethal | third instar larval stage (with Khc⁸)

Khc⁷⁴

lethal | third instar larval stage (with Khc⁷⁴)

Khc⁸

partially lethal - majority die, with Khc⁸, Scer\GAL4^repo.PL, Scer\GAL4^repo

Khc^GD12278

partially lethal - majority die, with Khc^GD12278, Scer\GAL4^repo.PL, Scer\GAL4^repo

Khc⁸

partially lethal - majority die, with Scer\GAL4^elav-C155

Khc^GD12278

partially lethal - majority die, with Scer\GAL4^repo.PL, Scer\GAL4^repo

Khc^GD12278

partially lethal - majority die | larval stage

partially lethal - majority die | pupal stage, with Scer\GAL4^pnr-MD237

Khc^GD12278

Other Phenotypes

Allele

behavior defective

behavior defective | recessive

body color defective, with Scer\GAL4^pnr-MD237

Khc^GD12278

developmental rate defective | larval stage, with Scer\GAL4^D42

Khc^{N262S.Scer\UAS}

flightless, with Scer\GAL4^D42

Khc^{N262S.Scer\UAS}

locomotor behavior defective (with Dp(1;2;Y)w⁺)

Khc¹⁶

locomotor behavior defective | adult stage, with Scer\GAL4^elav.PU, Scer\GAL80^ts.αTub84B

Khc^{N262S.Scer\UAS}

locomotor behavior defective | adult stage, with Scer\GAL4^Gli-J29-Gal4

Khc^GD12278

locomotor behavior defective | adult stage, with Scer\GAL4^moody.SPG

Khc^GD12278

locomotor behavior defective | adult stage, with Scer\GAL4^Mz97

Khc^GD12278

locomotor behavior defective | adult stage, with Scer\GAL4^repo.PL, Scer\GAL4^repo

Khc^GD12278

locomotor behavior defective | larval stage

Khc^unspecified

locomotor behavior defective | larval stage, with Scer\GAL4^D42

Khc^{N262S.Scer\UAS}

locomotor behavior defective | larval stage, with Scer\GAL4^repo.PL, Scer\GAL4^repo

Khc^GD12278

neuroanatomy defective, with Scer\GAL4^repo.PL, Scer\GAL4^repo

Khc^GD12278

neuroanatomy defective (with Df(2R)Jp6)

Khc⁶

neuroanatomy defective | recessive

Khc^k13314

neuroanatomy defective | recessive | somatic clone | third instar larval stage

Khc²⁷

neuroanatomy defective | somatic clone

Khc⁸

neuroanatomy defective | third instar larval stage, with Scer\GAL4^moody.SPG

Khc^GD12278

neuroanatomy defective | third instar larval stage, with Scer\GAL4^nrv2.PS

Khc^GD12278

neurophysiology defective

neurophysiology defective | larval stage, with Khc^{N262S.Scer\UAS}, Scer\GAL4^D42

Khc^Scer\UAS.cFa

neurophysiology defective | larval stage, with Khc^Scer\UAS.cFa, Scer\GAL4^D42

Khc^{N262S.Scer\UAS}

neurophysiology defective | larval stage, with Scer\GAL4^D42

Khc^{N262S.Scer\UAS}

neurophysiology defective | third instar larval stage, with Scer\GAL4^Gli-J29-Gal4

Khc^GD12278

neurophysiology defective | third instar larval stage, with Scer\GAL4^repo.PL, Scer\GAL4^repo

Khc^GD12278

paralytic (with Khc⁸)

Khc⁷⁴

paralytic (with Khc²⁷)

Khc⁷⁴

paralytic (with Khc⁷⁴)

paralytic | larval stage

paralytic | larval stage, with Scer\GAL4^D42

Khc^{N262S.Scer\UAS}

paralytic | larval stage (with Khc¹⁷)

Khc²⁷

paralytic | larval stage (with Khc²⁷)

Khc¹⁷

paralytic | third instar larval stage (with Df(2R)Jp6)

Khc⁷⁴

short lived, with Scer\GAL4^D42

Khc^{N262S.Scer\UAS}

visible, with Scer\GAL4^pnr-MD237

Khc^GD12278

visible | recessive | somatic clone

wild-type

wild-type, with Scer\GAL4^hs.2sev

Khc^{Scer\UAS.T:Ecol\lacZ}

Phenotype manifest in

Allele

adult cuticle & scutellar bristle | somatic clone

axon

axon (with Dp(1;2;Y)w⁺)

Khc¹⁶

axon (with Tp(1;3)w^vco)

Khc¹⁶

chorion | germline clone

class IV dendritic arborizing neuron | somatic clone

Khc²⁷

dendrite

Khc^k13314

dorsal appendage | germline clone

Khc²⁷

dorsal appendage | germline clone | maternal effect

embryo | germline clone

Khc²⁷

embryonic/larval glial cell, with Scer\GAL4^repo.PL, Scer\GAL4^repo

Khc^GD12278

embryonic/larval nervous system

Khc⁸

embryonic/larval neuromuscular junction | larval stage, with Khc^{N262S.Scer\UAS}, Scer\GAL4^D42

Khc^Scer\UAS.cFa

embryonic/larval neuromuscular junction | larval stage, with Khc^Scer\UAS.cFa, Scer\GAL4^D42

Khc^{N262S.Scer\UAS}

embryonic/larval neuromuscular junction | larval stage, with Scer\GAL4^D42

Khc^{N262S.Scer\UAS}

embryonic/larval peripheral nervous system | third instar larval stage, with Scer\GAL4^moody.SPG

Khc^GD12278

embryonic/larval wrapping glial cell of the eye disc | third instar larval stage, with Scer\GAL4^nrv2.PS

Khc^GD12278

eye | somatic clone

eye photoreceptor cell & endoplasmic reticulum | somatic clone

eye photoreceptor cell & multivesicular body | somatic clone

eye photoreceptor cell | somatic clone

follicle cell & mitochondrion | germ-line clone

Khc²⁷

germline cyst & mitochondrion | germ-line clone

Khc²⁷

lateral transverse muscle

macrochaeta | somatic clone

mesothoracic tergum, with Scer\GAL4^pnr-MD237

Khc^GD12278

microchaeta | somatic clone

microtubule

microtubule & oocyte | oogenesis stage S9 | germ-line clone

Khc²⁷

mitochondrial cloud | germline clone

Khc²⁷

mitochondrion

Khc²⁷

mitochondrion, with Scer\GAL4^repo.PL, Scer\GAL4^repo

Khc^GD12278

mitochondrion (with Khc⁶)

Khc²⁷

mitochondrion (with Khc¹⁷)

Khc²⁷

mitochondrion (with Khc²⁷)

neuromuscular junction

nurse cell fusome | germline clone

Khc²⁷

ommatidium | somatic clone

oocyte

oocyte & nucleus | germ-line clone

oocyte | germline clone

Khc²⁷

oocyte nucleus

Khc^pgs1

peripheral nervous system, with Scer\GAL4^repo.PL, Scer\GAL4^repo

Khc^GD12278

pole plasm

Khc²⁷

pole plasm | germline clone

Khc²⁷

posterior fascicle & axon

Khc¹⁶

rhabdomere | somatic clone

scutellar bristle | somatic clone

stage S9 oocyte & nucleus | germ-line clone

Khc²⁷

trichogen cell, with Scer\GAL4^pnr-MD237

Khc^GD12278

Classical Alleles ( 62 )

For All Classical Alleles Show

Allele of Khc	Class	Mutagen	Stocks	Known lesion
Khc⁸	amorphic allele - genetic evidence	ethyl methanesulfonate	2	Yes
Khc^e02141		piggyBac transposase	2	--
Khc^k13219		P-element activity	2	--
Khc^k13314		P-element activity	2	--
Khc^1ts	heat sensitive loss of function allele	ethyl methanesulfonate	1	Yes
Khc⁴		ethyl methanesulfonate	1	Yes
Khc²⁰	amorphic allele - genetic evidence		0	--
Khc²⁷	loss of function allele, amorphic allele - genetic evidence	ethyl methanesulfonate	0	Yes
Khc¹⁰		ethyl methanesulfonate	0	Yes
Khc^10B12		ethyl methanesulfonate	0	--
Khc¹¹		ethyl methanesulfonate	0	Yes
Khc¹²		ethyl methanesulfonate	0	Yes
Khc^12C1		ethyl methanesulfonate	0	--
Khc¹³		ethyl methanesulfonate	0	Yes
Khc¹⁵		ethyl methanesulfonate	0	Yes
Khc¹⁶	antimorphic allele - genetic evidence		0	--
Khc^16E8		ethyl methanesulfonate	0	--
Khc¹⁷	hypomorphic allele - genetic evidence	ethyl methanesulfonate	0	Yes
Khc¹⁸		ethyl methanesulfonate	0	Yes
Khc¹⁹		ethyl methanesulfonate	0	Yes
Khc²²	hypomorphic allele - genetic evidence	ethyl methanesulfonate	0	Yes
Khc²³		ethyl methanesulfonate	0	Yes
Khc²⁴		ethyl methanesulfonate	0	Yes
Khc²		ethyl methanesulfonate	0	Yes
Khc³¹		ethyl methanesulfonate	0	Yes
Khc³²		ethyl methanesulfonate	0	Yes
Khc³⁴		ethyl methanesulfonate	0	Yes
Khc³⁵		ethyl methanesulfonate	0	Yes
Khc³⁶		ethyl methanesulfonate	0	Yes
Khc³⁷		ethyl methanesulfonate	0	Yes
Khc³		ethyl methanesulfonate	0	Yes
Khc^5.287	loss of function allele	ethyl methanesulfonate	0	--
Khc⁵⁸		ethyl methanesulfonate	0	Yes
Khc⁵	hypomorphic allele - genetic evidence	ethyl methanesulfonate	0	Yes
Khc⁶¹		ethyl methanesulfonate	0	Yes
Khc⁶²		ethyl methanesulfonate	0	Yes
Khc⁶³		ethyl methanesulfonate	0	Yes
Khc⁶⁴		ethyl methanesulfonate	0	Yes
Khc⁶⁶		ethyl methanesulfonate	0	Yes
Khc⁶⁷		ethyl methanesulfonate	0	Yes
Khc⁶⁸		ethyl methanesulfonate	0	Yes
Khc⁶	hypomorphic allele - genetic evidence	ethyl methanesulfonate	0	Yes
Khc^6D10		ethyl methanesulfonate	0	--
Khc^7.288	loss of function allele	ethyl methanesulfonate	0	--
Khc⁷⁴		ethyl methanesulfonate	0	Yes
Khc⁷⁵		ethyl methanesulfonate	0	Yes
Khc⁷⁶	hypomorphic allele - genetic evidence	ethyl methanesulfonate	0	Yes
Khc⁷⁷	hypomorphic allele - genetic evidence	ethyl methanesulfonate	0	Yes
Khc⁷		ethyl methanesulfonate	0	Yes
Khc^7J9		ethyl methanesulfonate	0	--
Khc^8.70	loss of function allele	ethyl methanesulfonate	0	--
Khc⁹		ethyl methanesulfonate	0	Yes
Khc^A20.6		ethyl methanesulfonate	0	--
Khc^A4.12		ethyl methanesulfonate	0	--
Khc^B14.5		ethyl methanesulfonate	0	--
Khc^BD	hypomorphic allele - genetic evidence	ethyl methanesulfonate	0	--
Khc^G5.8		ethyl methanesulfonate	0	--
Khc^I14.6		ethyl methanesulfonate	0	--
Khc^K5.14		ethyl methanesulfonate	0	--
Khc^pgs1		ethyl methanesulfonate	0	--
Khc^pgs2		ethyl methanesulfonate	0	--
Khc^unspecified		ethyl methanesulfonate	0	--

Alleles Carried on Transgenic Constructs ( 26 )

For All Alleles Carried on Transgenic Constructs Show

Allele of Khc	Class	Mutagen	Stocks	Known lesion
Khc^GD12278		in vitro construct - RNAi in vitro construct - regulatory fusion	2	Yes
Khc^{248-2134.Scer\UAS.T:Avic\GFP-EGFP}		in vitro construct - regulatory fusion in vitro construct - coding region fusion	1	Yes
Khc^GL00330		in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
Khc^HMS01519		in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
Khc^JF01939		in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
Khc^+t7.5		in vitro construct - genomic fragment	0	Yes
Khc^{1-849.αTub67C.T:Avic\GFP}		in vitro construct - regulatory fusion in vitro construct - coding region fusion	0	Yes
Khc^{1-975.αTub67C.T:Avic\GFP}		in vitro construct - regulatory fusion in vitro construct - coding region fusion	0	Yes
Khc^4R-A		in vitro construct - amino acid replacement	0	Yes
Khc^4R		in vitro construct	0	Yes
Khc^dsRNA.cGa		in vitro construct - RNAi	0	Yes
Khc^dsRNA.cLa		in vitro construct - RNAi	0	Yes
Khc^{E97.Hsp83.T:Ecol\lacZ}		in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement	0	Yes
Khc^{fl.T:Avic\GFP}		in vitro construct - coding region fusion	0	Yes
Khc^{ftz.T:Ecol\lacZ}		in vitro construct - regulatory fusion	0	Yes
Khc^K.ftz		in vitro construct - regulatory fusion	0	Yes
Khc^{N262S.Scer\UAS}	antimorphic allele - genetic evidence	in vitro construct - regulatory fusion in vitro construct - amino acid replacement in vitro construct - site directed mutagenesis	0	Yes
Khc^NIG.7765R		in vitro construct - RNAi	0	Yes
Khc^{Scer\UAS.C.T:Avic\GFP}		in vitro construct - regulatory fusion in vitro construct - coding region fusion	0	Yes
Khc^Scer\UAS.cFa		in vitro construct - regulatory fusion	0	Yes
Khc^Scer\UAS.cSa		in vitro construct - regulatory fusion	0	Yes
Khc^{Scer\UAS.N.T:Avic\GFP}		in vitro construct - coding region fusion in vitro construct - regulatory fusion	0	Yes
Khc^{Scer\UAS.T:Ecol\lacZ}		in vitro construct - regulatory fusion	0	Yes
Khc^t7.5		in vitro construct - genomic fragment	0	Yes
Khc^{tCH322-162G07}		in vitro construct - genomic fragment	0	Yes
Khc^{Ubi-p63E.T:Hsap\MYC}		in vitro construct - regulatory fusion in vitro construct - coding region fusion	0	Yes

Aneuploid Aberrations

Disrupted in

Df(2R)BSC309

(Christensen and Cook, 2007.5.8)

Df(2R)BSC609

(Christensen et al., 2008.9.3)

Df(2R)BSC888

(Cook and Cook, 2010.10.13)

Df(2R)Exel6063

(Ryder, 2004.4.26)

Df(2R)Jp6

(Torroja et al., 1999, Saxton et al., 1991, Gho et al., 1992, Hurd and Saxton, 1996)

Df(2R)Jp7

(Saxton et al., 1991, Hurd et al., 1996)

Df(2R)Jp8

(Halsell and Kiehart, 1998, Liu et al., 1999)

Not disrupted in

Df(2R)Jp4

(BDGP Project Members, 1994-1999)

Df(2R)Jp7

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

heat-shock construct

UAS construct

P{UAS-Khc::nod::lacZ}

reporter construct

characterization construct

P{UASp-Khc::nod::lacZ}

P{Ubi-p63E-Khc.Myc}

P{αTub67C-Khc.1-849-GFP}

P{αTub67C-Khc.1-975-GFP}

PBac{CH322-162G07}

Insertions

Type of insertions

Name

Expression data

miscellaneous insertions

PBac{RB}Khc^e02141

insertion of enhancer trap

P{lacW}Khc^k13219

P{lacW}Khc^k13314

P{lacW}l(2)SH0474^SH0474

Gene Ontology: Function, Process & Cellular Component ( 34 unique terms )

Terms Based on Experimental Evidence ( 27 terms )

Molecular Function

CV term

References

microtubule binding

inferred from direct assay

microtubule motor activity

inferred from direct assay

(Ali et al., 2008, Gagliano et al., 2010, Sung et al., 2008)

Biological Process

CV term

(Gindhart et al., 2003, Schmidt et al., 2012)

References

axon cargo transport

inferred from mutant phenotype

axon guidance

inferred from mutant phenotype

(Berger et al., 2008)

axonogenesis

inferred from mutant phenotype

(Satoh et al., 2008)

cytoplasmic transport

inferred from mutant phenotype

(Serbus et al., 2005)

dendrite morphogenesis

inferred from mutant phenotype

(Satoh et al., 2008)

establishment of nucleus localization

inferred from mutant phenotype

(Metzger et al., 2012)

eye photoreceptor cell differentiation

inferred from genetic interaction with Gl

intracellular distribution of mitochondria

inferred from mutant phenotype

intracellular protein transport

inferred from mutant phenotype

(Henthorn et al., 2011)

maintenance of cell polarity

inferred from mutant phenotype

(Henthorn et al., 2011)

microtubule-based movement

inferred from direct assay

(Ali et al., 2008, Sung et al., 2008)

microtubule-based transport

inferred from direct assay

(Gagliano et al., 2010)

mitochondrion distribution

inferred from mutant phenotype

(Cox and Spradling, 2006)

mitochondrion transport along microtubule

inferred from mutant phenotype

(Pilling et al., 2006)

neuron projection morphogenesis

inferred from mutant phenotype

(Henthorn et al., 2011)

oocyte dorsal/ventral axis specification

inferred from mutant phenotype

oocyte microtubule cytoskeleton polarization

inferred from mutant phenotype

(Zimyanin et al., 2007)

pole plasm assembly

inferred from mutant phenotype

(Cha et al., 2002)

regulation of pole plasm oskar mRNA localization

inferred from mutant phenotype

(Brendza et al., 2000)

skeletal muscle fiber development

inferred from mutant phenotype

(Metzger et al., 2012)

Cellular Component

CV term

References

cytoplasm

inferred from direct assay

kinesin complex

inferred from direct assay

microtubule associated complex

inferred from direct assay

(Hughes et al., 2008)

microtubule plus end

inferred from direct assay

colocalizes_with
mitochondrion

inferred from direct assay

(Pilling et al., 2006)

Terms Based on Predictions or Assertions ( 12 terms )

Molecular Function

CV term

(FlyBase Curators et al., 2004-)

References

ATP binding

inferred from electronic annotation with InterPro:IPR001752, InterPro:IPR019821

microtubule binding

inferred from sequence or structural similarity with EMBL:AF067180

microtubule motor activity

inferred from sequence or structural similarity

(Goldstein and Gunawardena, 2000)

inferred from sequence or structural similarity with EMBL:AF067180

non-traceable author statement

motor activity

non-traceable author statement

plus-end-directed microtubule motor activity

traceable author statement

(Brendza et al., 2000)

Biological Process

CV term

cytoplasmic transport, nurse cell to oocyte

References

traceable author statement

(Cohen, 2002)

microtubule-based movement

inferred from sequence or structural similarity

(Goldstein and Gunawardena, 2000)

inferred from sequence or structural similarity with EMBL:AF067180

non-traceable author statement

neuronal action potential propagation

non-traceable author statement

neurotransmitter secretion

non-traceable author statement

pole plasm oskar mRNA localization

non-traceable author statement

(Cohen, 2002)

regulation of pole plasm oskar mRNA localization

traceable author statement

(Tekotte and Davis, 2002)

Cellular Component

CV term

(Goldstein and Gunawardena, 2000)

References

kinesin complex

inferred from sequence or structural similarity

inferred from sequence or structural similarity with EMBL:AF067180

non-traceable author statement

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

protein-protein

Interacting group

Assay

References

Khc - CG11876

anti tag coimmunoprecipitation, peptide massfingerprinting

Khc - CG14024

anti tag coimmunoprecipitation, peptide massfingerprinting

Khc - CG16979

anti tag coimmunoprecipitation, peptide massfingerprinting

Khc - CG3164

anti tag coimmunoprecipitation, peptide massfingerprinting

Khc - CG31910

anti tag coimmunoprecipitation, peptide massfingerprinting

Khc - CG3714

anti tag coimmunoprecipitation, peptide massfingerprinting

Khc - CG8654

anti tag coimmunoprecipitation, peptide massfingerprinting

Khc - CSN4

anti tag coimmunoprecipitation, peptide massfingerprinting

Khc - Cyp9b2

anti tag coimmunoprecipitation, peptide massfingerprinting

Khc - Hsp23

anti tag coimmunoprecipitation, peptide massfingerprinting

(Loiseau et al., 2010, Guruharsha et al., 2011, Mintseris et al., 2009.11.23)

Khc - Klc

anti tag coimmunoprecipitation, anti tag western blot, experimental knowledge based, peptide massfingerprinting

Khc - Pat1

anti tag coimmunoprecipitation, anti tag western blot, western blot

(Loiseau et al., 2010)

Khc - Prosβ6

anti tag coimmunoprecipitation, peptide massfingerprinting

Khc - Snap

anti tag coimmunoprecipitation, peptide massfingerprinting

Khc - TfIIEα

anti tag coimmunoprecipitation, peptide massfingerprinting

Khc - Tm1

anti tag coimmunoprecipitation, peptide massfingerprinting

Khc - Uba1

anti tag coimmunoprecipitation, peptide massfingerprinting

Khc - a6

anti tag coimmunoprecipitation, peptide massfingerprinting

Khc - porin

anti tag coimmunoprecipitation, peptide massfingerprinting

Khc - rpr

anti tag coimmunoprecipitation, peptide massfingerprinting

(Mintseris et al., 2009.11.23, Guruharsha et al., 2011)

Khc - tkv

anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based

Khc - wee

anti tag coimmunoprecipitation, peptide massfingerprinting

(Torroja et al., 1999, Gunawardena and Goldstein, 2001)

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

Khc allele

Gene

References

Khc⁴

Khc⁵

Khc⁶

Khc⁸

(Gunawardena et al., 2003)

Khc⁹

htt

Khc^k13314

(Martin et al., 1997, Martin et al., 1999)

Khc^unspecified

Dhc64C

Klc

(Martin et al., 1999)

unspecified

Aplip1

(Gassman et al., 1997, Gassman et al., 1999, Horiuchi et al., 2005)

Unc-76

(Gindhart et al., 2001)

External Data

y¹ w^*; P{UAS-Khc.EGFP}2/CyO

BioGRID - A database of protein and genetic interactions

•

62529

DPiM - DPiM, Drosophila Protein interaction Map

•

FBgn0001308

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0001308

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

36810

Orthologs

OrthoDB Orthologs (51) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

EOG6B8JZD

Dipteran inclusive ortholog search

EOG68WC92

Insect inclusive ortholog search

EOG60CGBX

Arthropod inclusive ortholog search

EOG6ZGMT9

Metazoa inclusive ortholog search

EOG65J4Q6

Orthologs in Drosophila Species (EOG6B8JZD)

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA20572

Drosophila persimilis

Dper\GL11356

Drosophila willistoni

Dwil\GK20895

Drosophila virilis

Dvir\GJ22020

Drosophila mojavensis

Dmoj\GI20293

Drosophila grimshawi

Dgri\GH19755

Orthologs in non-Drosophila Dipterans (EOG68WC92)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL008542

Anopheles gambiae

Malaria mosquito

Agam\AGAP000561

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ006688

Orthologs in non-Dipteran Insects (EOG60CGBX)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Apis mellifera

Western honey bee

Amel\GB47281

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG007909

Acromyrmex echinatior

Panamanian leafcutter ant

Aech\AECH19301

Atta cephalotes

Leafcutter ant

Acep\ACEP15122

Camponotus floridanus

Florida carpenter ant

Cflo\CFLO20247

Harpegnathos saltator

Jerdons jumping ant

Hsal\HSAL13261

Linepithema humile

Argentine ant

Lhum\LH18015

Pogonomyrmex barbatus

Red harvester ant

Pbar\PB22769

Solenopsis invicta

Red fire ant

Sinv\SINV24703

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI002812

Bombyx mori

Silkmoth

Bmor\BGIBMGA006809

Pediculus humanus

Human body louse

Phum\PHUM578890

Tribolium castaneum

Red flour beetle

Tcas\Khc

Orthologs in non-Insect Arthropods (EOG6ZGMT9)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Daphnia pulex

Water flea

Dpux\matK

Ixodes scapularis

Deer tick

Isca\ISCW014331

Orthologs in non-Arthropod Metazoa (EOG65J4Q6)

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Caenorhabditis elegans

Nematode

Cele\unc-116

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_021656gn

Danio rerio

Zebrafish

Drer\si:ch73-130n22.1

Danio rerio

Zebrafish

Drer\OTTDARG00000025494

Danio rerio

Zebrafish

Drer\kif5ba

Danio rerio

Zebrafish

Drer\kif5c

Danio rerio

Zebrafish

Drer\kif5bb

Xenopus tropicalis

Western clawed frog

Xtro\kif5c

Xenopus tropicalis

Western clawed frog

Xtro\kif5b

Xenopus tropicalis

Western clawed frog

Xtro\kif5a

Gallus gallus

Domestic chicken

Ggal\KIF5B

Gallus gallus

Domestic chicken

Ggal\KIF5C

Mus musculus

House mouse

Mmus\Kif5b

Mus musculus

House mouse

Mmus\Kif5c

Mus musculus

House mouse

Mmus\Kif5a

Rattus norvegicus

Norway rat

Rnor\Kif5b

Rattus norvegicus

Norway rat

Rnor\Kif5a

Rattus norvegicus

Norway rat

Rnor\Kif5c

Homo sapiens

Human

Hsap\KIF5B

Homo sapiens

Human

Hsap\ENSG00000168280

Homo sapiens

Human

Hsap\KIF5A

Human Orthologs (3)

Gene

OMIM

HGNC

Hsap\KIF5B

Hsap\ENSG00000168280

Hsap\KIF5A

AAA Orthologs (11) based on analysis using Dmel annotation version 4.3

Organism

Gene

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA20572

Drosophila persimilis

Dper\GL11356

Drosophila willistoni

Dwil\GK20895

Drosophila virilis

Dvir\GJ22020

Drosophila mojavensis

Dmoj\GI20293

Drosophila grimshawi

Dgri\GH19755

Stocks & Reagents

Stocks Listed in FlyBase ( 16 )

Bloomington

31994

w^*; Khc^1ts/CyO

1607

b¹ pr¹ Khc⁸/CyO

9648

25898

y¹ v¹; P{TRiP.JF01939}attP2

18018

w¹¹¹⁸; PBac{RB}Khc^e02141/CyO

31995

y¹ w^*; pr¹ Khc⁴/SM6a

11077

y¹ w^67c23; P{lacW}Khc^k13219/CyO

11084

y¹ w^67c23; P{lacW}Khc^k13314/CyO

Harvard

PBac{RB}Khc^e02141

Kyoto

106414

b¹ pr¹ Khc⁸/CyO

VDRC

v44337

w¹¹¹⁸ P{GD12278}v44337

v44338

w¹¹¹⁸; P{GD12278}v44338/TM3

More stocks available...

Genomic Clones ( 1 )

BACR25I17

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 34 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

DPiM_SD02406

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

DRSC - Results from RNAi screens.

•

FBgn0001308

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

36810

Antibody Information

Other Information

Discoverer

Etymology

The gene is named "partagas", after a brand of Cuban cigars, due to the mutant eggshell phenotype.

Identification

Relationship to Other Genes

Source for database identity of

Source for database merge of

Source for merge of: Khc l(2)k13219

Source for merge of: Khc l(2)k13314

(Spradling et al., 1999)

Source for merge of: Khc l(2)W12

(Steward, 2000.8.14)

Additional comments

Other Comments

4 alleles of Khc have been isolated in a screen for mutants with defects in dorsoventral patterning of the eggshell.

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Posterior localisation of Dynein and dorsal-ventral axis formation in the oocyte is dependent on Khc.

(Palacios and St. Johnston, 2002)

Khc restricts pole plasm formation to the posterior by moving osk mRNA away from microtubule-rich lateral and anterior cortical regions.

(Cha et al., 2002)

Khc is required for all cytoplasmic movements in the oocyte and for the posterior localisation of Dhc64C. Klc is not required for any of the functions of kinesin in the oocyte.

Khc is required for posterior localisation of osk mRNA and stau.

(Brendza et al., 2000)

Homologous genetic loci in D.subobscura and D.melanogaster tend to show a similar ultrastructure in the two species.

(Cuenca et al., 1998)

Analysis of Khc-ncd fusion proteins indicates that residues or regions contributing to motor polarity are present in the Khc motor core region.

(Endow and Waligora, 1998)

Using crystallographic data an atomic resolution model of the motor domain dimer is built, this dimer can be successfully 'docked' into the three-dimensional framework of the maps from electron cryomicroscopy.

(Kozielski et al., 1998)

Chromophore-assisted light inactivation (CALI) can destroy kinesin activity in at least two ways: loss of motor activity or irreversible attachment of the kinesin enzyme to its microtubule substrate.

(Surrey et al., 1998)

Studies of N-terminal Khc fragments reveals that more than one kinesin head is required for continuous movement at maximal velocity.

(Young et al., 1998)

The reciprocal location of nod and Khc fusion proteins indicates microtubule polarity in the oocyte, epithelium, neuron and muscle.

(Clark et al., 1997)

A study of Khc movement along microtubules suggests a fundamental enzymatic cycle for kinesin in which hydrolysis of a single ATP molecule is coupled to a step distance of the microtubule protofilament lattice spacing of 8.12nm.

(Hua et al., 1997)

Analysis of recombinant Khc fragments in which the neck domain is shortened or replaced by an artificial random coil suggests that the neck domain does not act as a rigid lever arm to magnify the structural change at the catalytic domain but instead it acts as a flexible joint to guarantee the mobility of the motor domain.

(Inoue et al., 1997)

Medium-resolution three-dimensional structure of microtubules interacting with two functional dimeric motors with opposite directionality (Khc and ncd) is determined.

(Arnal et al., 1996)

Mutations in Khc enhance the para and mel and suppress the Sh and eag mutant phenotypes. Khc activity is required for normal inward sodium currents during neuronal action potentials, but mutants do not affect the driving force on sodium ions. Loss of Khc function may inhibit the anterograde axonal transport of vesicles bearing sodium channels.

(Hurd et al., 1996)

Khc mutations cause axonal swellings that are filled with the cargoes of fast axonal transport, including many membrane-bounded organelles and synaptic membrane proteins. Mutations also inhibit motor axon terminal development. Impaired kinesin function causes a general disruption of fast axonal transport that in turn leads to dystrophic neuron development, length-dependent defects in neurotransmission and progressive distal paralysis.

(Hurd and Saxton, 1996)

The crystal structure of the MgADP complex of the ncd motor domain is determined to 2.5A by X ray crystallography and compared to the Khc motor domain. The domains are similar in structure and locations of conserved surface amino acids suggest the motors share a common microtubule-binding site. Structural and functional comparisons indicate the NTPases may have a similar strategy of changing conformation between NTP and NDP states.

(Sablin et al., 1996)

ncd and Khc differ in their initial, weak binding to microtubules which causes the proteins to move in opposite directions. The nature of a structural bias that may serve as a determinant of motor polarity is not clear, results suggest the microtubule binding site may determine direction.

(Song and Endow, 1996)

Truncated Khc molecules having only a single motor domain do not show detectable processive movement along a microtubule in a gliding assay, which is consistent with a model in which Khc's two force-generating heads operate by a hand-over-hand mechanism.

(Vale et al., 1996)

Observations of truncated Khc derivatives with either two or one mechanochemical head suggest that the ability of single two-headed kinesin molecules to drive continuous movement results from a hand-over-hand mechanism in which one head remains bound to the microtubule while the other detaches and moves forwards.

(Berliner et al., 1995)

Clonal analysis in the eye reveals that Khc mutant tissue has missing or disorganized facets, abnormal lens structure and bristle multiplications, as well as disorganization of the ommatidial array. Individual ommatidia may have abnormal numbers of photoreceptors.

(Brendza et al., 1995)

Studies of the oligomeric states of truncated Khc proteins indicates that the region between amino acids 367 and 401 of Khc either contains a dimerisation domain or that dimerisation is strongly affected by the removal of this region.

(Correia et al., 1995)

Comparison of monomeric and dimeric Khc derivatives demonstrates that dimeric derivatives contain structures distinct from the rod domain that induce the formation of dimers with mechanochemical activities analogous to those of the native kinesin. The one-headed derivative displays microtubule-stimulated ATPase activity and is functional is a motility assay. Also the one headed enzyme fails to track microtubule protofilaments.

(Gelles et al., 1995)

Direct measurement of the kinetics of Khc dissociation from microtubules, the release of phosphate and ADP from kinesin and rebinding of kinesin to the microtubule have defined the mechanism for the kinase ATPase cycle and provides an explanation for the motility difference between skeletal myosin and kinesin.

(Gilbert et al., 1995)

Rapid kinetic techniques are used to define a mechanism for the microtubule - kinesin ATPase using Khc motor domain.

(Gilbert et al., 1995)

Studies of a bacterially expressed head domain demonstrate it represents a biologically relevant and fully characterised protein preparation useful for mechanistic studies.

(Johnson and Gilbert, 1995)

Mixtures of Khc motor domain protein treated with the zero-length cross linker EDC generates covalently cross linked products of Khc with βTub56D and Khc with αTub84B. These results indicate that the Khc motor domain interacts with both βTub56D and αTub84B.

(Walker, 1995)

Identified as a 120kD polypeptide in an ATP MAPs 1-24 hour embryonic fraction.

(Cole et al., 1994)

The pre-steady-state kinetics of the microtubule^.kinesin ATPase pathway is studied using a mutant of Khc and chemical quench flow techniques to measure steps of ATP binding, ATP hydrolysis and ADP release during the first turnover of the enzyme.

(Gilbert and Johnson, 1994)

The sequence of the Khc protein has been compared with the sequences of a variety of kinesin family proteins.

(Goodson et al., 1994)

A truncated Khc protein consising of the N terminal 401 amino acids, containing both the ATP and microtubule binding sites, behaves as native kinesin with respect to steady state properties, having full catalytic activity with microtubules.

(Gilbert and Johnson, 1993)

Drosphila kinesin heavy chain has been used in a study of the interaction of the kinesin motor domain with the microtubule surface: binding becomes saturated at one kinesin head per heterodimer.

A series of truncated kinesin heavy chain and ncd proteins were generated and assayed for movement along microtubules in vitro: conserved domain of both proteins has microtubule motor activity, and direction of movement is intrinsic to conserved motor domain.

(Stewart et al., 1993)

Ultrastructural analysis of a Khc-α-Spec fusion protein suggests that the Khc stalk region forms a parallel dimer. Chemical-cross linking studies suggest that the two chains are in register. The stalk forms an α-helical coiled coil structure. Part of this α-helical structure may be less stable than the rest of the α-helical structure.

(de Cuevas et al., 1992)

Kinesin may be active in transport of ion channels and components of synaptic release machinery to appropriate cellular locations, but is not required for anterograde transport of synaptic vesicles/components.

(Gho et al., 1992)

Immunocytochemical and genetic analysis of the kinesin heavy chain gene indicates that the heavy chain is an essential protein. Normal heavy chain function is important in the neuromuscular system, but probably not for the basic cell cycle.

(Goldstein and Gunawardena, 2000, Stuart et al., 2007, Barbosa et al., 2007, Perkins et al., 1.15.2009, Berger et al., 2008, Hughes et al., 2008, Ni et al., 2011.7.19, Cammarato et al., 2011, Bridon et al., 2012)

Khc protein is able to induce microtubule movement in vitro.

(Yang et al., 1990)

Antibodies to Drosophila Khc cross-react with mammalian kinesin protein, and antibodies to bovine brain kinesin cross-react with Drosophila Khc protein.

(Neighbors et al., 1988)

Flies deficient for Khc survive through early embryogenesis (Saxton).

External Crossreferences & Linkouts

Sequence Crossreferences

RefSeq (Transcripts)

•

NM_057242

RefSeq (Proteins)

•

NP_476590

DDBJ / EMBL / GenBank

•

Entrez Gene - A searchable database of RefSeq genes.

•

36810

UniProtKB/Swiss-Prot

•

P17210

Other Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Kinesin, motor domain (IPR001752)

Kinesin, motor region, conserved site (IPR019821)

P-loop containing nucleoside triphosphate hydrolase (IPR027417)

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

•

SD02406

Linkouts

BioGRID - A database of protein and genetic interactions

•

62529

DPiM - DPiM, Drosophila Protein interaction Map

•

FBgn0001308

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0001308

DRSC - Results from RNAi screens.

•

FBgn0001308

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0001308

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG7765-RA

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0001308

GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents

•

36810

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

•

/cytoskel/kinesin1.htm

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

36810

modMine - Data generated by the modENCODE project.

•

FBgn0001308

Synonyms & Secondary IDs ( 35 )

Reported As

Symbol Synonym

CG7765

(Reddy and Reddy, 2002)

DKH

(Hackney, 2002, Stock et al., 1999, Hackney et al., 2009)

DmK

(Bornschlögl et al., 2009)

DmKHC

(Kim and Endow, 2000, Hirokawa et al., 1998, Henningsen et al., 1997, Moore and Endow, 1996, Goodson et al., 1994, Gutiérrez-Medina et al., 2009, Dagenbach and Endow, 2004, Hirokawa, 2012)

Dmkin

(Endow and Hatsumi, 1991)

Khc

(Anne et al., 2007, Moua et al., 2007, Tran and Welte, 2007, Cook and Estes, 2006.12.4, Cox and Spradling, 2006, Brendza, 2000.3.2, Brendza et al., 1999, Shapiro and Anderson, 2006, Christensen and Cook, 2007.5.8, Christensen et al., 2008.9.3, Schmidt et al., 2012, Lin et al., 2006, Navarro et al., 2004, Zimyanin et al., 2007, Martin et al., 2005, Pilling et al., 2006, Barkus et al., 2008, Kucherenko et al., 2008, Januschke et al., 2006, Wang and Riechmann, 2008, Kaltenbach et al., 2007, Shaklee et al., 2008, Kraft et al., 2006, Januschke et al., 2007, Zimyanin et al., 2008, Gervais et al., 2008, Goold and Davis, 2007, Mische et al., 2007, Shubeita et al., 2008, Toda et al., 2008, Dworkin et al., 2009, Krauss et al., 2009, Krauss et al., 2009, Vendra et al., 2007, Li et al., 2010, Venken et al., 2009, Johnson et al., 2009, Bitan et al., 2010, Gonsalvez et al., 2010, Loiseau et al., 2010, Cook and Cook, 2010.10.13, Wasbrough et al., 2010, Lerit and Gavis, 2011, Bianco et al., 2010, Djagaeva et al., 2012, Moua et al., 2011, Fisher et al., 2008, Serbus and Sullivan, 2007, Ferree et al., 2005, Füger et al., 2012, Bridon et al., 2012, Metzger et al., 2012, Sanghavi et al., 2012, Lloyd et al., 2012)

khc

(Schimmelpfeng and Goldstein, 2005, Vogt et al., 2003, Babu et al., 2004, Gaengel and Mlodzik, 2003, Whited et al., 2004, Cha et al., 2002, Tekotte and Davis, 2002, Januschke et al., 2002, Pellettieri and Seydoux, 2002, Sablin et al., 1998, Halsell and Kiehart, 1998, Gindhart et al., 1995, Brendza et al., 1995, Lane and Kalderon, 1994, Brendza et al., 1993, Hurd and Saxton, 1992, Saxton et al., 1991, Schimmelpfeng and Goldstein, 2006, Mochizuki et al., 2006, Satoh et al., 2007, Schimmelpfeng et al., 2007, Janody and Treisman, 2006, Gross et al., 2008, Barbosa et al., 2007, Fan et al., 2011, Boylan et al., 2008, Dahlgaard et al., 2007, Medina et al., 2008, Sung et al., 2008, Rezával et al., 2008, Satoh et al., 2008, Gaspar and Szabad, 2009, Kalifa et al., 2009, Berger et al., 2008, Xiong et al., 2010, Coffman et al., 2005, Henthorn et al., 2011, Ganguly et al., 2012, Lloyd et al., 2012, Reis et al., 2012)

KIF 5A

(Miki et al., 2001)

KIF5B

(Hirokawa, 2012.11.20)

KIN

(Bondinas et al., 2002, Bondinas et al., 2001)

Kin

(Surrey et al., 1998, Poulton and Deng, 2006, Klusza and Deng, 2007, Li et al., 2008)

kin

(Endow et al., 1990, Zheng et al., 2008, Kalifa et al., 2009)

kinesin

(Carter and Cross, 2005, Molloy and Schmitz, 2005, Loschi et al., 2009, Shastry and Hancock, 2010)

kinesin-1

(Fehr et al., 2009, Ruhnow et al., 2011)

Kinesin-1

(Telley et al., 2009)

l(2)k13219

l(2)k13314

(BDGP Project Members, 1994-1999, )

l(2)W12

(Steward, 2000.8.14, )

l(2R)W12

(Liu et al., 1999)

pgs

(Ogden et al., 2003, Poulton and Deng, 2006, Hartwig et al., 2008)

Name Synonym

conventional kinesin

(Kaan et al., 2011)

Kinesin

kinesin-1

(Kerssemakers et al., 2006, Glater et al., 2006, Serbus and Sullivan, 2008, Weaver and Goldstein, 2008, Josowitz et al., 2008, Seitz and Surrey, 2006, Fallesen et al., 2011, Watanabe et al., 2010, Guydosh and Block, 2009, Tucker et al., 2009, Bieling et al., 2008, Ally et al., 2009, Li et al., 2012, Crevenna et al., 2008, Kaan et al., 2011, Leidel et al., 2012, Reis et al., 2012)

kinesin 1

(Zimyanin et al., 2008)

Kinesin-1

(Oladipo et al., 2007, Bornschlögl et al., 2009, Vendra et al., 2007, Pack-Chung et al., 2007, Ferree et al., 2005)

kinesin-1 heavy chain

(Muthukrishnan et al., 2009, Li et al., 2010, Bianco et al., 2010)

Kinesin-1 heavy chain

(Gagliano et al., 2010)

Kinesin heavy chain

(Cox and Spradling, 2006, Wang and Riechmann, 2008, Januschke et al., 2007, Zimyanin et al., 2008, Gervais et al., 2008, Jolly et al., 2010, Rehmsmeier et al., 2004, Gonsalvez et al., 2010, Loiseau et al., 2010, Cammarato et al., 2011)

Kinesin Heavy Chain

(Serbus and Sullivan, 2007, Hirokawa, 2012.11.20)

kinesin heavy chain I

(Januschke et al., 2003)

kinesin I

(Welte, 2004, Tran and Welte, 2007)

kinesin α-chain

(Hackney and Stock, 2000)

kinesin α subunit

(Huang et al., 1994, Huang and Hackney, 1994)

partagas