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General Information
Symbol
Dmel\kn
Species
D. melanogaster
Name
knot
Annotation Symbol
CG10197
Feature Type
FlyBase ID
FBgn0001319
Gene Model Status
Stock Availability
Gene Summary
knot (kn) encodes a transcription factor required for somatic and alary muscle specification and embryonic head segmentation. In larvae, it is required for wing disc patterning and plays a key role in the lymph gland, both under normal conditions and under immune stress. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)
Also Known As

col, collier, collier/knot, knotted

Key Links
Genomic Location
Cytogenetic map
Sequence location
Recombination map
2-72
RefSeq locus
NT_033778 REGION:14772650..14807061
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (24 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000844136
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000844136
(assigned by GO_Central )
Biological Process (22 terms)
Terms Based on Experimental Evidence (17 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:ct; FB:FBgn0004198
inferred from mutant phenotype
involved_in head segmentation
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from direct assay
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from direct assay
inferred from high throughput mutant phenotype
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
traceable author statement
traceable author statement
traceable author statement
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000844136
(assigned by GO_Central )
traceable author statement
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Protein Family (UniProt)
Belongs to the COE family. (P56721)
Summaries
Gene Snapshot
knot (kn) encodes a transcription factor required for somatic and alary muscle specification and embryonic head segmentation. In larvae, it is required for wing disc patterning and plays a key role in the lymph gland, both under normal conditions and under immune stress. [Date last reviewed: 2019-03-14]
Gene Group (FlyBase)
BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS -
Basic helix-loop-helix (bHLH) transcription factors are sequence-specific DNA-binding proteins that regulate transcription. They are characterized by a 60 amino acid region comprising a basic DNA binding domain followed by a HLH motif formed from two amphipathic α-helices connected by a loop. bHLH transcription factors form homo- and hetero-dimeric complexes, which bind to a E box consensus sequence. (Adapted from PMID:15186484).
Protein Function (UniProtKB)
May act as a 'second-level regulator' of head patterning. Required for establishment of the PS(-1)/PS0 parasegmental border and formation of the intercalary segment. Required for expression of the segment polarity genes hedgehog, engrailed and wingless, and the segment-identity genes CAP and collar in the intercalary segment. Required at the onset of the gastrulation for the correct formation of the mandibular segment.
(UniProt, P56721)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
kn: knot
Veins L3 and L4 shifted closer together in region of anterior crossvein, which is either extremely thick or eliminated by regional fusion of L3 and L4. Frequently, extra crossvein between L3 and L4 near end of wing. Shift in positions of sensilla and extra chaetae accompanies shift in vein positions. Wing narrowed. Head narrowed and flattened, so the long axis of eye is at oblique angle. May overlap wild type at high temperatures and in late counts. Best at 19. RK2.
Summary (Interactive Fly)

EBF/Olf-1 homolog, HLH protein - required for the formation of the hypopharyngeal lobe - directly promotes Drosophila blood cell progenitor maintenance independently of the niche

Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
5

Please see the JBrowse view of Dmel\kn for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.44

Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0087465
3460
557
FBtr0112809
3926
575
FBtr0112810
3339
689
FBtr0301400
3457
556
FBtr0329882
2927
524
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0086595
60.5
557
8.69
FBpp0111721
62.5
575
8.53
FBpp0111722
74.8
689
8.41
FBpp0290614
60.4
556
8.69
FBpp0302917
57.5
524
8.64
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\kn using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

kn is expressed in two regions of the wing disc, a region of the wing hinge primordium in the posterior compartment and a stripe in the A region that abuts the anterior/posterior compartment boundary.

Transcript is detected in 7 cells anterior to the A/P boundary in third instar wing discs. However, expression is excluded from the D/V boundary that will form the wing margin.

kn transcripts are expressed in the anterior-most regions of the mandibular segment and also in the cephalic mesoderm.

In late embryonic stage 12, kn is only detected in one founder cell per hemisegment, the dorsal acute muscle 3 (DA3) founder cell. At stage 13, during the process of myoblast recruitment by the founder cell and as fusion proceeds, kn is activated in the nucleus of each newly incorporated myoblast. At stage 14, all nuclei incorporated in the DA3 syncytium actively transcribe kn.

Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data

kn is expressed in a promuscular cluster and the three derived precursor cells at the origin of dorsal-lateral muscles. Specifically, kn is expressed in the dorsal acute muscle 3 and dorsal oblique muscle 5 (DA3/DO5) precursor, the ventral lateral longitudinal muscle 1 and dorsal oblique muscle (LL1/DO4) precursor, and the dorsal transverse muscle and dorsal oblique muscle 3 (DT1/DO3) precursor. These muscle precursor cells are first observable at different times during embryonic stage 11.

kn expression is first detected in the ventral nerved cord at embryonic stage 12 in about 20 cells per hemisegment. This increases to about 50 cells per hemisegment at stage 14 and later. These are mainly (stage 12) and only (stage 14) postmitotic cells and are neurons and not glial cells.

kn protein is localized in a segmentally repeated pattern in the somatic mesoderm, in cell clusters in the same dorsal position in all trunk segments. At stage 11, those cell clusters have given rise to the muscle founder cells that will become the DA3/DO5 and DO4/DT1 progenitors, and continue to express kn protein. After asymmetric division of the muscle founder cells, kn expression is maintained only in the fusion competent cell corresponding to the DA3 muscle, then in the DA3 muscle.

kn is expressed in the NB5-6 lineage in thoracic and abdominal segments and in some more anterior segments in a late temporal window.

kn is expressed in class IV multidendritic neurons, specifically the vdaB, vdaa, and ddaC ventral multidendritic neurons and also in dorsal acute muscle 3 (DA3) somatic muscles in stage 15 embryos.

kn protein is first detected during embryonic development of the lymph gland at emrbyonic stage 11, in two separate clusters of cells in the dorsal-most mesoderm of thoracic segments T2 and T3. These clusters converge and coalesce by early stage 13, forming the lymph gland primordium. During stage 14, expression is progressively restricted to posterior-most cells of the developing lymph gland; at late embryonic stages, kn protein expression marks the posterior signalling center of the lymph gland.

Protein is detected in 7 cells anterior to the A/P boundary in third instar wing discs. However, expression is excluded from the D/V boundary that will form the wing margin.

Expression in mesodermal cells in segments T3, A1, and A2 is shown. At embryonic stage 10, kn is expressed in one and two clusters of mesodermal cells in T3 and A1-A2. At stage 11 kn expression is restricted to the muscle precursor cells (one in T3, two in A1,A2) singled out from each kn-positive premuscular cluster. By stage 12, kn is expressed in two founder cells resulting from the division of each progenitor. At stage 13, kn protein remains in two (T3) or four (A1,A2) muscle precursors. At stage 14, kn is only detected in the dorsal acute muscle 3 precursor.

Marker for
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
Reporter: P{col5-lacZ.C}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{GAL4}col85
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{kn-GAL4.2.6-1.6}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{kn-lacZ.4-0.9}
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{kn-lacZ.CRM276}
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\kn in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 27 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 25 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of kn
Transgenic constructs containing regulatory region of kn
Aberrations (Deficiencies and Duplications) ( 7 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
wing cell & wing vein L3 & wing vein L4
wing cell & wing vein L3 & wing vein L4 | somatic clone
Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
14 of 15
Yes
Yes
 
3  
12 of 15
No
Yes
1  
11 of 15
No
Yes
11 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
14 of 15
Yes
Yes
13 of 15
No
Yes
1  
11 of 15
No
Yes
1  
11 of 15
No
Yes
Rattus norvegicus (Norway rat) (4)
13 of 13
Yes
Yes
11 of 13
No
Yes
10 of 13
No
Yes
6 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (4)
10 of 12
Yes
Yes
9 of 12
No
Yes
2 of 12
No
Yes
2 of 12
No
Yes
Danio rerio (Zebrafish) (6)
13 of 15
Yes
Yes
12 of 15
No
Yes
11 of 15
No
Yes
10 of 15
No
Yes
7 of 15
No
Yes
2 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (1)
12 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (2)
1 of 15
Yes
Yes
1 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091905JN )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915089B )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W08VC )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0NUP )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0A9D )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (0)
No records found.
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Dmel gene
Ortholog showing functional complementation
Supporting References
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Interactions Browser

Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
suppressible
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Signaling Pathways (FlyBase)
Metabolic Pathways
External Data
Linkouts
Genomic Location and Detailed Mapping Data
Chromosome (arm)
2R
Recombination map
2-72
Cytogenetic map
Sequence location
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
51C2-51C3
Limits computationally determined from genome sequence between P{lacW}Rpn6k00103 and P{PZ}chn02064
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
51C1-51C2
(determined by in situ hybridisation)
51E-51F
(determined by in situ hybridisation)
Placed in 51B10--51C1 by deficiency mapping (details unspecified).
Experimentally Determined Recombination Data
Location

2-72.3

Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (25)
Genomic Clones (38)
cDNA Clones (50)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced
BDGP DGC clones
Other clones
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
RNAi and Array Information
Linkouts
DRSC - Results frm RNAi screens
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Laboratory Generated Antibodies
Commercially Available Antibodies
 
Other Information
Relationship to Other Genes
Source for database identify of
Source for database merge of

Source for merge of: kn col

Source for merge of: kn CG10197

Additional comments
Other Comments

DNA-protein interactions: genome-wide binding profile assayed for kn protein in 0-12 hr embryos; see mE1_TFBS_kn collection report.

Ectopic expression of kn increases arbor length and represses filopodia/spike formation in class III neurons.

10 alleles of kn have been recovered in a screen for mutations with smo-like mutant phenotypes in clones in the wing.

kn is required for the proper positioning of veins 3 and 4 in the wing and to prevent ectopic venation between them.

kn is required for the formation of the hypopharyngeal lobe and for subsequent differentiation of the ventral arms and lateralgrate of the pharyngeal head skeleton.

kn shows lineage-specific restriction of transcription to the founder of muscle DA3A during muscle development, which depends on the asymmetric segregation of numb gene product and involves repression by N signalling.

In kn mutant embryos the DA3A founder cells form but do not maintain kn transcription and are unable to fuse with neighboring myoblasts, leading to a loss-of-muscle DA3A phenotype.

The specification of the DA3A muscle lineage requires both kn and at least one other transcription factor.

kn is required for the establishment of the PS(-1)/PS0 parasegmental border and formation of the intercalary segment.

kn is a mediator of the short range organizing activity of hh in the wing.

kn has a specific role in hh-mediated patterning of the wing with no appreciable effect on general dpp-mediated wing organisation. kn acts in the hh-responsive cells at the posterior edge of the anterior compartment of the wing, primarily by preventing vein formation by these cells, thus forming a distinct intervein region between veins 3 and 4.

Mutants display hyperplastic phenotype, showing tissue overgrowth in mitotic recombination clones.

Mutations in kn cause extra longitudinal or transverse veins with plexated vein phenotypes. kn, fu and shf act synergistically against Px, px, net, dsr and emc.

The kn and fu loci belong to the knot phenotypic group within the 'excess-of-vein' mutant class. Mutants generate a medial shift in the position of the longitudinal veins, sensilla and chaetae. Double mutants are superadditive in vein pattern defects.

Origin and Etymology
Discoverer

Nichols-Skoog, 1st Aug. 1931.

Etymology
Identification
External Crossreferences and Linkouts ( 58 )
Sequence Crossreferences
NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
Other crossreferences
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
KEGG Genes - Molecular building blocks of life in the genomic space.
MARRVEL_MODEL - MARRVEL (model organism gene)
modMine - A data warehouse for the modENCODE project
SignaLink - A signaling pathway resource with multi-layered regulatory networks.
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results frm RNAi screens
FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
FlyMine - An integrated database for Drosophila genomics
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Synonyms and Secondary IDs (19)
Reported As
Symbol Synonym
col
(Carayon et al., 2020, Stratmann et al., 2019, Hao and Jin, 2017, Stratmann and Thor, 2017, Oyallon et al., 2016, Stratmann et al., 2016, Urbach et al., 2016, Benmimoun et al., 2015, Bivik et al., 2015, de Taffin et al., 2015, Simon and Guerrero, 2015, Bagley et al., 2014, Evans et al., 2014, Ferguson and Martinez-Agosto, 2014, Jiang et al., 2014, Wang et al., 2014, Morin-Poulard et al., 2013, Palm et al., 2013, Sinha et al., 2013, Boukhatmi et al., 2012, Eade et al., 2012, Enriquez et al., 2012, Tokusumi et al., 2012, Benito-Sipos et al., 2011, Demilly et al., 2011, Ntini and Wimmer, 2011, Cheng et al., 2010, Karlsson et al., 2010, Losada-Pérez et al., 2010, Makki et al., 2010, Seong et al., 2010, Baumgardt et al., 2009, Mosimann et al., 2009, Tokusumi et al., 2009, Baumgardt et al., 2008, Crozatier and Vincent, 2008, Daburon et al., 2008, Enriquez et al., 2008, Baumgardt et al., 2007, Claret et al., 2007, Dubois et al., 2007, Dubois et al., 2007, Jones, 2007, Krzemień et al., 2007, Mandal et al., 2007, Ruel et al., 2007, Bartscherer et al., 2006, Wendler et al., 2006, Glise et al., 2005, Gorfinkiel et al., 2005, Panakova et al., 2005, Torroja et al., 2005, Casali and Struhl, 2004, Crozatier et al., 2004, Crozatier et al., 2004, Ogden et al., 2004, Rajewsky and Socci, 2004, Crozatier et al., 2003, Hooper, 2003, Vegh and Basler, 2003, Glise et al., 2002, Johnson et al., 2002, Kambris et al., 2002, Tallafuss and Bally-Cuif, 2002, Amanai and Jiang, 2001, Haas et al., 2001, Ingham and McMahon, 2001, Capdevila and Johnson, 2000, Johnson et al., 2000, Vervoort, 2000, Chang et al., 1999, Crozatier and Vincent, 1999, Crozatier et al., 1999, Son, 1999.3.8, Vervoort et al., 1999, Crozatier et al., 1998, Dubois et al., 1998, Vervoort et al., 1998, Crozatier et al., 1997, Crozatier et al., 1996, Vincent, 1995)
kn
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Name Synonyms
Collier-Knot
Early B Cell Factor
Secondary FlyBase IDs
  • FBgn0014142
  • FBgn0033967
Datasets (1)
Study focus (1)
Experimental Role
Project
Project Type
Title
  • bait_protein
Genome-wide localization of transcription factors by ChIP-chip and ChIP-Seq.
References (326)