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Gene Dmel\kni

General Information
Symbol	Dmel\kni	Species	D. melanogaster
Name	knirps	Annotation symbol	CG4717
Feature type	protein_coding_gene	FlyBase ID	FBgn0001320
Created / Updated	2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	77E3-77E3	Sequence location	3L:20,685,430..20,688,463 [-]
Map ( GBrowse )	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene knirps is referred to in FlyBase by the symbol kni (CG4717, FBgn0001320). It has the cytological map location 77E3. Its sequence location is 3L:20685430..20688463. Its molecular function is described as: ligand-dependent nuclear receptor activity; transcription factor activity; specific transcriptional repressor activity; zinc ion binding; sequence-specific DNA binding. It is involved in the biological processes described with 13 unique terms, many of which group under: anatomical structure development; open tracheal system development; regulation of metabolic process; regulation of biological process; transcription, DNA-dependent; organ development; system development; embryonic pattern specification; trunk segmentation; cell cycle; anterior/posterior axis specification. 97 alleles are reported. The phenotypes of these alleles are annotated with 32 unique terms, many of which group under: embryonic abdomen; anatomical structure; embryonic segment; adult segment; thoracic segment; embryonic tagma; organ system; embryonic/larval tracheal system; adult mesothoracic segment; abdominal segment 7. It has one annotated transcript and one annotated polypeptide.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	kni: knirps Zygotic gap gene whose mutants are homozygous lethal; their denticle belts in segments one through seven are fused into a single field (Nusslein-Volhard and Wieschaus, 1980), but the head, thorax, eighth abdominal segment, and tail region appear normal. Embryos homozygous for a strong kni mutant show a wide band of ftz staining instead of the normal number of ftz stripes (Carroll and Scott, 1986). ri: radius incompletus ri: radius incompletus From Edith M. Wallace, unpublished. Vein L2 interrupted. Wings slightly warped and blunt. Acts during contraction period in D. simulans, inhibiting fusion of small spaces into a vein (Waddington, 1940, J. Genet. 41: 75-139). RK1.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 77E3-77E3   Limits computationally determined from genome sequence between P{EP}trblEP3519 and P{EP}fngEP3082&P{lacW}skdL7062
Experimentally Determined Cytological Location
Cytogenetic map Notes References 77E1-77E2 (determined by in situ hybridisation)   (Ranz et al., 1997) 77E1-77E2 (determined by in situ hybridisation)   (Nauber et al., 1988)
Experimentally Determined Recombination Data
Location	3-46.8 (Arajarvi and Hannah-Alava, 1969) 2-47 (Kalisch and Rasmuson, 1974) 3-47 (Duncan and Kaufman, 1975) 3-47.0 (Tearle and Nusslein-Volhard, 1987) 3-47.1 (Meyer, 1952)
Left of (cM)	Pc (Puro and Nygren, 1975) Su(var)3-3 (Reuter et al., 1986)
Right of (cM)	Sgs3 (Kokoza et al., 1982)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\kni for information on other features
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) kni-RA FBtr0078283  NM_079463   2085   429
Additional Transcript Data & Comments
Reported size (kB)	2.5, 2.2 (northern blot) (Nauber et al., 1988)
Comments	A 2 kb cDNA was sequenced. It is not known which transcript it corresponds to. (Nauber et al., 1988, Rivera-Pomar et al., 1995)
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein kni-PA   FBpp0077941   45.6   429   8.35     NP_524187   AAF51629
Additional Polypeptide Data & Comments
Reported size (kD)	429 (aa); 45.6 (kD predicted) (Nauber et al., 1988)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0001320
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Vitamin D receptor (IPR000324) Zinc finger, nuclear hormone receptor-type (IPR001628) Zinc finger, NHR/GATA-type (IPR013088) TRANSFAC - Eukaryotic transcription factors, their genomic binding sites, and DNA-binding profiles • R02619 R02620 R04959 R04960 R04961 R04962 T00445
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA540371   AE003592 AAF51629   AI388412   AY118798 AAM50658   CO289698   CO329526   EC059958   EC070261   EC239345   EC240793   EC242701   X13331 CAA31709
UniProtKB/Swiss-Prot	P10734
UniProtKB/TrEMBL
Maps to
Does NOT map to
Identified with	GH19318 (BDGP Project Members, 2000-) D1121 (BDGP Project Members, 1994-1999)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References aberration junction Tp(3;2)kni-FC82.bk2 3L:20,690,666..20,692,381 comment=The proximal breakpoint on 3L maps ~2.5kb upstream of the kni transcription unit. The deletion removes the kni and knrl transcription units. Overlaps the Tp(3;2)kni-FC82 deletion by less than 1kb. linked_to=EcoRI-EcoRI_rfrag (Lunde et al., 1998) aberration junction Df(3L)kni[ri-XT2].bk1 3L:20,690,666..20,692,381 comment=Distal breakpoint of a ~50kb deletion with breaks ~2.5kb upstream of the kni transcription unit and 45-50kb further upstream. Overlaps the Df(3L)kni[ri-XT2] deletion by less than 1kb. linked_to=EcoRI-EcoRI_rfrag (Lunde et al., 1998) point mutation kni[ri-53j] 3L:20,700,376..20,700,376 comment=Single base pair change in the putative regulatory region for wing vein L2 expression. Regulatory region with point muation when placed in reporter construct, fails to drive expression in wing vein L2. (Note that the reported base change is on the opposite strand and in relation to the EcoRI-XhoI fragment.) evidence=experimental na_change=G20641117T reported_na_change=C596A (Lunde et al., 2003) point mutation kni[12] 3L:20,687,379..20,687,379 evidence=experimental na_change=C20628120T pr_change=T21I|kni-PA reported_na_change=C2640T reported_pr_change=T21I (Gerwin et al., 1994) point mutation kni[T] 3L:20,687,134..20,687,134 evidence=experimental na_change=G20627875A pr_change=R31H|kni-PA reported_na_change=G2884A reported_pr_change=R31H (Gerwin et al., 1994) point mutation kni[11] 3L:20,687,084..20,687,084 evidence=experimental na_change=T20627825A pr_change=C48S|kni-PA reported_na_change=T2934A reported_pr_change=C48S (Gerwin et al., 1994) point mutation kni[2] 3L:20,687,084..20,687,084 evidence=experimental na_change=T20627825A pr_change=C48S|kni-PA reported_na_change=T2934A reported_pr_change=C48S (Gerwin et al., 1994) point mutation kni[5] 3L:20,687,041..20,687,041 evidence=experimental na_change=G20627782A pr_change=R62H|kni-PA reported_na_change=G2977A reported_pr_change=R62H (Gerwin et al., 1994) point mutation kni[1] 3L:20,687,017..20,687,017 evidence=experimental na_change=G20627758A pr_change=G70D|kni-PA reported_na_change=G3001A reported_pr_change=G70D (Gerwin et al., 1994) point mutation kni[6] 3L:20,686,793..20,686,793 evidence=experimental na_change=C20627534T pr_change=Q145@|kni-PA reported_na_change=C3225T reported_pr_change=?145@ (Gerwin et al., 1994) point mutation kni[7] 3L:20,686,672..20,686,672 evidence=experimental na_change=C20627413A pr_change=S185@|kni-PA reported_na_change=C3347A reported_pr_change=?185@ (Gerwin et al., 1994) protein binding site kni-protein_bind-1 3L:20,700,420..20,700,428 bound_moiety=sd-XP comment=A mutation in this site along with two other Sd-binding sites in a kni wing reporter construct leads to complete loss of wing disc expression. evidence=experimental bound_moiety=Sd-XP (Bergman et al., 2004, Lunde et al., 2003) protein binding site kni-protein_bind-2 3L:20,700,350..20,700,358 bound_moiety=sd-XP bound_moiety=Sd-XP comment=A mutation in this site along with two other Sd-binding sites in a kni wing reporter construct leads to complete loss of wing disc expression.(binding site reported on opposite strand with respect to kni gene transcription) evidence=experimental (Lunde et al., 2003, Bergman et al., 2004) protein binding site kni-protein_bind-3 3L:20,700,303..20,700,311 bound_moiety=Sd-XP bound_moiety=sd-XP comment=(binding site reported on opposite strand with respect to kni gene transcription) evidence=experimental (Lunde et al., 2003, Bergman et al., 2004) protein binding site kni-protein_bind-4 3L:20,700,243..20,700,251 bound_moiety=Sd-XP bound_moiety=sd-XP evidence=experimental (Lunde et al., 2003, Bergman et al., 2004) protein binding site kni-protein_bind-5 3L:20,700,051..20,700,068 bound_moiety=sd-XP comment=Tandem Sd-binding site. A mutation in this site along with two other Sd-binding sites in a kni wing reporter construct leads to complete loss of wing disc expression. (binding site reported on opposite strand with respect to kni gene transcription) evidence=experimental bound_moiety=Sd-XP (Bergman et al., 2004, Lunde et al., 2003) protein binding site kni-protein_bind-6 3L:20,690,647..20,690,657 bound_moiety=cad-XP comment=cad binding site 1 evidence=experimental (Bergman et al., 2004, Rivera-Pomar et al., 1995) protein binding site kni-protein_bind-7 3L:20,690,610..20,690,622 bound_moiety=cad-XP comment=cad binding site 2. The binding site has two extra T residues in the reference sequence relative to the reported sequence. evidence=experimental (Rivera-Pomar et al., 1995) protein binding site kni-protein_bind-8 3L:20,690,583..20,690,593 bound_moiety=cad-XP comment=cad binding site 3 evidence=experimental (Rivera-Pomar et al., 1995) protein binding site kni-protein_bind-9 3L:20,690,557..20,690,567 bound_moiety=cad-XP comment=cad binding site 4 evidence=experimental (Rivera-Pomar et al., 1995) protein binding site kni-protein_bind-10 3L:20,690,527..20,690,537 bound_moiety=cad-XP comment=cad binding site 5 evidence=experimental (Rivera-Pomar et al., 1995) protein binding site kni-protein_bind-11 3L:20,690,504..20,690,513 bound_moiety=bcd-XP comment=bcd binding site 1 evidence=experimental (Rivera-Pomar et al., 1995) protein binding site kni-protein_bind-12 3L:20,690,494..20,690,503 bound_moiety=bcd-XP comment=bcd binding site 2 evidence=experimental (Rivera-Pomar et al., 1995) protein binding site kni-protein_bind-13 3L:20,690,492..20,690,502 bound_moiety=cad-XP comment=cad binding site 6 evidence=experimental (Rivera-Pomar et al., 1995) protein binding site kni-protein_bind-14 3L:20,690,483..20,690,492 bound_moiety=bcd-XP comment=bcd binding site 3 evidence=experimental (Rivera-Pomar et al., 1995) protein binding site kni-protein_bind-15 3L:20,690,468..20,690,482 bound_moiety=bcd-XP comment=bcd binding site 4 evidence=experimental (Rivera-Pomar et al., 1995) protein binding site kni-protein_bind-16 3L:20,690,462..20,690,471 bound_moiety=bcd-XP comment=bcd binding site 5 evidence=experimental (Rivera-Pomar et al., 1995) protein binding site kni-protein_bind-17 3L:20,690,452..20,690,461 bound_moiety=bcd-XP comment=bcd binding site 6 evidence=experimental (Rivera-Pomar et al., 1995) protein binding site kni-protein_bind-18 3L:20,690,400..20,690,407 bound_moiety=hb-XP comment=hb binding site 1 evidence=experimental (Pankratz et al., 1992) protein binding site kni-protein_bind-19 3L:20,690,359..20,690,366 bound_moiety=hb-XP comment=hb binding site 2 evidence=experimental (Pankratz et al., 1992) protein binding site kni-protein_bind-20 3L:20,690,221..20,690,228 bound_moiety=hb-XP comment=hb binding site 3 evidence=experimental (Pankratz et al., 1992, Bergman et al., 2004) protein binding site kni-protein_bind-21 3L:20,690,190..20,690,197 bound_moiety=hb-XP comment=hb binding site 4 evidence=experimental (Pankratz et al., 1992, Bergman et al., 2004) protein binding site kni-protein_bind-22 3L:20,690,054..20,690,061 bound_moiety=hb-XP comment=hb binding site 5 evidence=experimental (Pankratz et al., 1992) protein binding site kni-protein_bind-23 3L:20,690,032..20,690,039 bound_moiety=hb-XP comment=hb binding site 6 (weak site) evidence=experimental (Pankratz et al., 1992, Bergman et al., 2004) protein binding site kni-protein_bind-24 3L:20,689,985..20,689,993 bound_moiety=tll-XP comment=tll binding site 1 evidence=experimental (Pankratz et al., 1992) protein binding site kni-protein_bind-25 3L:20,689,961..20,689,969 bound_moiety=tll-XP comment=tll binding site 2 (last base differs from that reported in FBrf0057643). evidence=experimental (Pankratz et al., 1992) protein binding site kni-protein_bind-26 3L:20,689,859..20,689,867 bound_moiety=tll-XP comment=tll binding site 3 evidence=experimental (Pankratz et al., 1992) protein binding site kni-protein_bind-27 3L:20,689,798..20,689,808 bound_moiety=Kr-XP comment=Kr binding site K1 evidence=experimental (Pankratz et al., 1989) protein binding site kni-protein_bind-28 3L:20,689,768..20,689,778 bound_moiety=Kr-XP comment=Kr binding site K2 evidence=experimental (Pankratz et al., 1989) protein binding site kni-protein_bind-29 3L:20,689,643..20,689,651 bound_moiety=tll-XP comment=tll binding site 4 evidence=experimental (Pankratz et al., 1992) protein binding site kni-protein_bind-30 3L:20,689,688..20,689,713 bound_moiety=tll-XP evidence=experimental (Pankratz et al., 1992, Bergman et al., 2004) protein binding site kni-protein_bind-31 3L:20,690,695..20,690,707 bound_moiety=hb-XP evidence=experimental (Bergman et al., 2004, Rivera-Pomar et al., 1995) protein binding site kni-protein_bind-32 3L:20,689,735..20,689,750 bound_moiety=tll-XP evidence=experimental (Bergman et al., 2004, Pankratz et al., 1992) protein binding site kni-protein_bind-33 3L:20,689,700..20,689,725 bound_moiety=hb-XP evidence=experimental (Rivera-Pomar et al., 1995, Bergman et al., 2004) protein binding site kni-protein_bind-34 3L:20,690,704..20,690,712 bound_moiety=cad-XP evidence=experimental (Rivera-Pomar et al., 1995, Bergman et al., 2004) protein binding site kni-protein_bind-35 3L:20,689,701..20,689,724 bound_moiety=Kr-XP evidence=experimental (Rivera-Pomar et al., 1995, Bergman et al., 2004) protein binding site kni-protein_bind-36 3L:20,690,525..20,690,540 bound_moiety=hb-XP evidence=experimental (Rivera-Pomar et al., 1995, Bergman et al., 2004) protein binding site kni-protein_bind-37 3L:20,690,503..20,690,509 bound_moiety=His2B-XP evidence=experimental (Kerrigan and Kadonaga, 1992, Bergman et al., 2004) protein binding site kni-protein_bind-38 3L:20,690,492..20,690,499 bound_moiety=His2B-XP evidence=experimental (Bergman et al., 2004, Kerrigan and Kadonaga, 1992) protein binding site kni-protein_bind-39 3L:20,690,484..20,690,489 bound_moiety=His2B-XP evidence=experimental (Kerrigan and Kadonaga, 1992, Bergman et al., 2004) protein binding site kni-protein_bind-40 3L:20,690,473..20,690,480 bound_moiety=His2B-XP evidence=experimental (Kerrigan and Kadonaga, 1992, Bergman et al., 2004) protein binding site kni-protein_bind-41 3L:20,690,462..20,690,468 bound_moiety=His2B-XP evidence=experimental (Bergman et al., 2004, Kerrigan and Kadonaga, 1992) protein binding site kni-protein_bind-42 3L:20,690,058..20,690,072 bound_moiety=gt-XP evidence=experimental (Rivera-Pomar et al., 1995, Bergman et al., 2004) protein binding site kni-protein_bind-43 3L:20,690,035..20,690,046 bound_moiety=gt-XP evidence=experimental (Bergman et al., 2004, Rivera-Pomar et al., 1995) protein binding site kni-protein_bind-44 3L:20,689,796..20,689,814 bound_moiety=Kr-XP evidence=experimental (Bergman et al., 2004, Rivera-Pomar et al., 1995) protein binding site kni-protein_bind-45 3L:20,689,776..20,689,792 evidence=experimental bound_moiety=tll-XP (Bergman et al., 2004, Pankratz et al., 1992) protein binding site kni-protein_bind-46 3L:20,689,764..20,689,783 bound_moiety=Kr-XP evidence=experimental (Bergman et al., 2004, Rivera-Pomar et al., 1995) protein binding site kni-protein_bind-47 3L:20,689,632..20,689,649 bound_moiety=Kr-XP evidence=experimental (Bergman et al., 2004, Rivera-Pomar et al., 1995) protein binding site kni-protein_bind-48 3L:20,689,636..20,689,649 bound_moiety=hb-XP evidence=experimental (Rivera-Pomar et al., 1995, Bergman et al., 2004) protein binding site kni-protein_bind-49 3L:20,689,640..20,689,656 bound_moiety=tll-XP evidence=experimental (Bergman et al., 2004, Pankratz et al., 1992) protein binding site kni-protein_bind-50 3L:20,689,819..20,689,839 bound_moiety=Kr-XP evidence=experimental (Bergman et al., 2004, Rivera-Pomar et al., 1995) protein binding site kni-protein_bind-51 3L:20,689,743..20,689,766 bound_moiety=hb-XP evidence=experimental (Bergman et al., 2004, Pankratz et al., 1992) regulatory region kni-reg_element-1 3L:20,699,781..20,701,141 comment=Region sufficient to direct the correct spatial pattern of kni expression in the wing vein L2 primordium in wing imaginal discs. linked_to=XhoI-EcoRI_rfrag (Lunde et al., 2003) regulatory region kni-reg_element-2 3L:20,688,236..20,693,017 comment=Region sufficient to direct the correct spatial pattern of kni expression in the anterior and posterior domains in the blastoderm embryo. evidence=experimental linked_to=BamHI-NruI_rfrag (Pankratz et al., 1989) regulatory region kni-reg_element-3 3L:20,689,640..20,690,516 comment=Fragment directs kni wild-type-like abdominal expression pattern in blastoderm embryos. linked_to=KpnI-DraI_rfrag (Pankratz et al., 1992) regulatory region kni-reg_element-4 3L:20,690,014..20,690,464 comment=Fragment required for setting the anterior boundary of kni expression in the abdomen in blastoderm embryos. evidence=experimental linked_to=PstI-EcoRI_rfrag (Pankratz et al., 1992) regulatory region kni-reg_element-5 3L:20,689,640..20,690,019 comment=Fragment required for setting the posterior boundary of kni expression in the abdomen in blastoderm embryos. linked_to=EcoRI-DraI_rfrag (Pankratz et al., 1992) rescue fragment kni[tRa] 3L:20,684,656..20,694,194 comment=Fragment rescues the kni mutant abdominal segment pattern and weakly rescues the head defects. evidence=experimental linked_to=SalI-HindIII_rfrag (Rothe et al., 1992) sequence variant kni[ri-1] 3L:20,700,201..20,700,452 comment=252bp deletion in the putative regulatory region for wing vein L2 expression. evidence=experimental (Lunde et al., 2003) sequence variant kni[ri-92f] 3L:20,700,201..20,700,452 comment=252bp deletion in the putative regulatory region for wing vein L2 expression. kni[ri-92f] may be a re-isolate of the kni[ri-1] allele. evidence=experimental (Lunde et al., 2003) sequence variant kni[riM] 3L:20,700,201..20,700,452 comment=252bp deletion in the putative regulatory region for wing vein L2 expression. kni[riM] may be a re-isolate of the kni[ri-1] allele. evidence=experimental (Lunde et al., 2003) sequence variant kni[8] 3L:20,688,019..20,690,019 comment=The approximately 2kb kni[8] deletion lies within the EcoRI-BamHI fragment. evidence=experimental linked_to=EcoRI-BamHI_rfrag (Nauber et al., 1988, Ruden and Jaeckle, 1995) sequence variant kni[3] 3L:20,686,285..20,686,529 comment=Deletion of 245bp leads to a frameshift, producing a protein with the N-terminal 232 amino acids of kni followed by an additional 105 amino acids. evidence=experimental (Gerwin et al., 1994)
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 5954
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference  embryonic stage | cellular blastoderm   (Nauber et al., 1988)  embryonic stage | stage 4   (Boring et al., 1993)  embryonic stage | stage 4   (Rivera-Pomar et al., 1995)  embryonic stage   (Nauber et al., 1988)  embryonic stage | early   (Gavis and Lehmann, 1992)  larval stage | third instar  wing vein L2 | precursor (Lunde et al., 1998)  embryonic stage | stage 4   (Rivera-Pomar et al., 1995)  embryonic stage | stage 4   (Rivera-Pomar et al., 1995)  embryonic stage | blastoderm   (Hulskamp et al., 1990)
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001320 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0001320 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0001320
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable knid10922 kniri-53j kniri-92f kniri-M3 kniri-XT2 kniriM lethal kni2FKE.eve lethal | embryonic stage | recessive kni3 lethal | embryonic stage | gap | recessive kniunspecified lethal | embryonic stage, with Scer\GAL4pnr-MD237 kniScer\UAS.cLa Other Phenotypes Allele wild-type knitRa visible kniri-1 kniri-2 kniri-51k kniri-53j kniri-92f kniri-M1 kniri-M2 kniri-M3 kniri-M4 kniri-XT2 kniriM visible | recessive kniri-1 kniri-92f kniri-XT2 visible | conditional - heat sensitive knihs.PR visible, with Scer\GAL4Bx-MS1096 kniScer\UAS.cLa mitotic cell cycle defective, with Scer\GAL4fkh.14-3 kniScer\UAS.cCa Sterility Allele fertile knid10922 Phenotype manifest in Allele abdomen kni1 kni3 extended germ band embryo kni10 kni2 abdominal segment 1 kni11 kni2 kni8 abdominal segment 2 kni11 kni2 kni8 abdominal segment 3 kni11 kni2 kni8 abdominal segment 4 kni11 kni2 kni8 abdominal segment 5 kni11 kni2 kni8 abdominal segment 6 kni11 kni2 kni8 abdominal segment 7 kni11 kni2 kni8 mesothoracic ventral denticle belt kni2FKE.eve mesothoracic segment kni2FKE.eve mesothoracic segment | ventral kni2FKE.eve embryonic abdominal segment 1 kniIIIE48 embryonic abdominal segment 2 kniIIIE48 embryonic abdominal segment 3 kniIIIE48 embryonic abdominal segment 4 kniIIIE48 embryonic abdominal segment 5 kniIIIE48 embryonic abdominal segment 6 kniIIIE48 embryonic abdominal segment 7 kniIIIE48 embryonic abdominal segment 8 kniIIIE48 embryonic abdominal segment 9 kniIIIE48 embryonic abdominal segment 10 kniIIIE48 embryonic abdominal segment 11 kniIIIE48 embryonic/larval dorsal anastomosis, with Scer\GAL4btl.PS kniScer\UAS.cCa embryonic dorsal trunk, with Scer\GAL4btl.PS kniScer\UAS.cCa adherens junction & embryonic dorsal trunk, with Scer\GAL4btl.PS kniScer\UAS.cCa wing, with Scer\GAL4Bx-MS1096 kniScer\UAS.cLa metathoracic femur, with Scer\GAL4Bx-MS1096 kniScer\UAS.cLa adult thorax & macrochaeta, with Scer\GAL4Bx-MS1096 kniScer\UAS.cLa abdominal segment kniT wing vein | conditional - heat sensitive knihs.PR wing | conditional - heat sensitive knihs.PR wing vein | ectopic | conditional - heat sensitive knihs.PR wing vein L2 kniri-1 kniri-2 kniri-51k kniri-53j kniri-92f kniri-M1 kniri-M2 kniri-M3 kniri-M4 kniri-XT2 kniriM wing kniri-1 kniri-2 kniri-51k embryonic dorsal branch knitRa embryonic/first instar larval cuticle & abdominal segment 1 kniunspecified embryonic/first instar larval cuticle & abdominal segment 2 kniunspecified embryonic/first instar larval cuticle & abdominal segment 3 kniunspecified embryonic/first instar larval cuticle & abdominal segment 4 kniunspecified embryonic/first instar larval cuticle & abdominal segment 5 kniunspecified embryonic/first instar larval cuticle & abdominal segment 6 kniunspecified embryonic/first instar larval cuticle & abdominal segment 7 kniunspecified macrophage kniunspecified embryo | gap kniunspecified
Classical Alleles ( 35 )
For All Classical Alleles Show
Allele of kni Class Mutagen Stocks Known lesion kni10 amorph, loss of function ethyl methanesulfonate 3 -- kni11 loss of function ethyl methanesulfonate 0 -- kni12 ethyl methanesulfonate 0 -- kni1 ethyl methanesulfonate 1 -- kni2 loss of function ethyl methanesulfonate 0 -- kni3 ethyl methanesulfonate 0 Yes kni4 ethyl methanesulfonate 0 -- kni5 loss of function ethyl methanesulfonate 1 -- kni5H 0 -- kni6 loss of function ethyl methanesulfonate 3 Yes kni7 loss of function ethyl methanesulfonate 0