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Gene Dmel\kto

General Information
Symbol	Dmel\kto	Species	D. melanogaster
Name	kohtalo	Annotation symbol	CG8491
Feature type	protein_coding_gene	FlyBase ID	FBgn0001324
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	MED12, dTRAP230, Trap230
Genomic Location
Chromosome (arm)	3L	Recombination map	3-46
Cytogenetic map	76D1-76D1	Sequence location	3L:19,829,714..19,838,044 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene kohtalo is referred to in FlyBase by the symbol Dmel\kto (CG8491, FBgn0001324). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; RNA polymerase II transcription cofactor activity. There is experimental evidence that it is involved in the biological process: chaeta development; positive regulation of Wnt receptor signaling pathway; compound eye development; sex comb development; imaginal disc-derived leg segmentation; regulation of transcription from RNA polymerase II promoter. 22 alleles are reported. The phenotypes of these alleles are annotated with: wing margin; eye disc; trichogen cell; antennal disc; photoreceptor cell; heart primordium; mesothoracic tergum. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Mediator complex, subunit Med12; Mediator complex, subunit Med12, LCEWAV-domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1628801_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of kto. Gene sequence location is 3L:19829714..19838044.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	kto: kohtalo (J.A. Kennison) Isolated as a dominant suppressor of Pc mutations. Also suppresses Pcl alleles as well as Msc, Mrt, and AntpScx. Associated with recessive larval lethality.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features BKN22025 HFA10983 Controlled Vocabulary Terms imaginal disc-derived leg segmentation
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 76D1-76D1   Limits computationally determined from genome sequence between P{lacW}l(3)L3809L3809 and P{lacW}l(3)L1243L1243&P{lacW}Mi-2j3D4
Experimentally Determined Cytological Location
Cytogenetic map Notes References 76D1-76D1     (Treisman, 2000.11.27) 76B-76D   Location from complementation analysis with deficiency and duplication chromosomes (details unspecified).   (Kennison and Tamkun, 1988)
Experimentally Determined Recombination Data
Location	3-46 (Kennison and Tamkun, 1988)
Left of (cM)	P{FRT(whs)}2A (de Ayala Alonso et al., 2007)
Right of (cM)	th (de Ayala Alonso et al., 2007)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\kto for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	DGC clone appears problematic (SD08305): incomplete CDS
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) kto-RA FBtr0074884  NM_080047   7740   2531 kto-RB FBtr0304716     1723   534
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein kto-PA   FBpp0074653   279.5   2531   7.60     NP_524786   AAF49103 kto-PB   FBpp0293259   58.0   534   12.01
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Mediator complex, subunit Med12 (IPR019035) Mediator complex, subunit Med12, LCEWAV-domain (IPR021990)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF49103   AF324426 AAG48328   AI297658   AI542171   AY122257 AAM52769   BF486389   BF487965   BF488367   BF489947   BF495656   BT072834   BT100264   CK658772   CO310703   EC064706
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VW47
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference larval stage   organism | ubiquitous   • nucleus (Janody et al., 2003) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0001324    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0001324 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0001324 expression level Developmental Stage   Expression Level embryo 00-02hr    1164 embryo 02-04hr    1071 embryo 04-06hr    2755 embryo 06-08hr    2674 embryo 08-10hr    1944 embryo 10-12hr    1132 embryo 12-14hr    1146 embryo 14-16hr    1088 embryo 16-18hr    660 embryo 18-20hr    648 embryo 20-22hr    443 embryo 22-24hr    392 larva L1    529 larva L2    417 larva L3 12hr old    402 larva L3 puffstage 1-2    500 larva L3 puffstage 3-6    1032 larva L3 puffstage 7-9    938 white prepupae new    883 white prepupae 12hr    1172 white prepupae 24hr    1791 pupae 2d postWPP    811 pupae 3d postWPP    497 pupae 4d postWPP    532 adult male 01day    674 adult male 05day    810 adult male 30day    927 adult female 01day    777 adult female 05day    875 adult female 30day    884 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1164) embryo 02-04hr  (1071) embryo 04-06hr  (2755) embryo 06-08hr  (2674) embryo 08-10hr  (1944) embryo 10-12hr  (1132) embryo 12-14hr  (1146) embryo 14-16hr  (1088) embryo 16-18hr  (660) embryo 18-20hr  (648) embryo 20-22hr  (443) embryo 22-24hr  (392) larva L1  (529) larva L2  (417) larva L3 12hr old  (402) larva L3 puffstage 1-2  (500) larva L3 puffstage 3-6  (1032) larva L3 puffstage 7-9  (938) white prepupae new  (883) white prepupae 12hr  (1172) white prepupae 24hr  (1791) pupae 2d postWPP  (811) pupae 3d postWPP  (497) pupae 4d postWPP  (532) adult male 01day  (674) adult male 05day  (810) adult male 30day  (927) adult female 01day  (777) adult female 05day  (875) adult female 30day  (884) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1164 embryo 02-04hr    1071 embryo 04-06hr  (2755) embryo 06-08hr  (2674) embryo 08-10hr  (1944) embryo 10-12hr    1132 embryo 12-14hr    1146 embryo 14-16hr    1088 embryo 16-18hr    660 embryo 18-20hr    648 embryo 20-22hr    443 embryo 22-24hr    392 larva L1    529 larva L2    417 larva L3 12hr old    402 larva L3 puffstage 1-2    500 larva L3 puffstage 3-6    1032 larva L3 puffstage 7-9    938 white prepupae new    883 white prepupae 12hr    1172 white prepupae 24hr  (1791) pupae 2d postWPP    811 pupae 3d postWPP    497 pupae 4d postWPP    532 adult male 01day    674 adult male 05day    810 adult male 30day    927 adult female 01day    777 adult female 05day    875 adult female 30day    884 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1164 embryo 02-04hr    1071 embryo 04-06hr    2755 embryo 06-08hr    2674 embryo 08-10hr    1944 embryo 10-12hr    1132 embryo 12-14hr    1146 embryo 14-16hr    1088 embryo 16-18hr    660 embryo 18-20hr    648 embryo 20-22hr    443 embryo 22-24hr    392 larva L1    529 larva L2    417 larva L3 12hr old    402 larva L3 puffstage 1-2    500 larva L3 puffstage 3-6    1032 larva L3 puffstage 7-9    938 white prepupae new    883 white prepupae 12hr    1172 white prepupae 24hr    1791 pupae 2d postWPP    811 pupae 3d postWPP    497 pupae 4d postWPP    532 adult male 01day    674 adult male 05day    810 adult male 30day    927 adult female 01day    777 adult female 05day    875 adult female 30day    884 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1164 embryo 02-04hr    1071 embryo 04-06hr    2755 embryo 06-08hr    2674 embryo 08-10hr    1944 embryo 10-12hr    1132 embryo 12-14hr    1146 embryo 14-16hr    1088 embryo 16-18hr    660 embryo 18-20hr    648 embryo 20-22hr    443 embryo 22-24hr    392 larva L1    529 larva L2    417 larva L3 12hr old    402 larva L3 puffstage 1-2    500 larva L3 puffstage 3-6    1032 larva L3 puffstage 7-9    938 white prepupae new    883 white prepupae 12hr    1172 white prepupae 24hr    1791 pupae 2d postWPP    811 pupae 3d postWPP    497 pupae 4d postWPP    532 adult male 01day    674 adult male 05day    810 adult male 30day    927 adult female 01day    777 adult female 05day    875 adult female 30day    884 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0001324 expression level Developmental Stage   Expression Level embryo 00-02hr    1164 embryo 02-04hr    1071 embryo 04-06hr    2755 embryo 06-08hr    2674 embryo 08-10hr    1944 embryo 10-12hr    1132 embryo 12-14hr    1146 embryo 14-16hr    1088 embryo 16-18hr    660 embryo 18-20hr    648 embryo 20-22hr    443 embryo 22-24hr    392 larva L1    529 larva L2    417 larva L3 12hr old    402 larva L3 puffstage 1-2    500 larva L3 puffstage 3-6    1032 larva L3 puffstage 7-9    938 white prepupae new    883 white prepupae 12hr    1172 white prepupae 24hr    1791 pupae 2d postWPP    811 pupae 3d postWPP    497 pupae 4d postWPP    532 adult male 01day    674 adult male 05day    810 adult male 30day    927 adult female 01day    777 adult female 05day    875 adult female 30day    884 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1164) embryo 02-04hr  (1071) embryo 04-06hr  (2755) embryo 06-08hr  (2674) embryo 08-10hr  (1944) embryo 10-12hr  (1132) embryo 12-14hr  (1146) embryo 14-16hr  (1088) embryo 16-18hr  (660) embryo 18-20hr  (648) embryo 20-22hr  (443) embryo 22-24hr  (392) larva L1  (529) larva L2  (417) larva L3 12hr old  (402) larva L3 puffstage 1-2  (500) larva L3 puffstage 3-6  (1032) larva L3 puffstage 7-9  (938) white prepupae new  (883) white prepupae 12hr  (1172) white prepupae 24hr  (1791) pupae 2d postWPP  (811) pupae 3d postWPP  (497) pupae 4d postWPP  (532) adult male 01day  (674) adult male 05day  (810) adult male 30day  (927) adult female 01day  (777) adult female 05day  (875) adult female 30day  (884) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1164 embryo 02-04hr    1071 embryo 04-06hr  (2755) embryo 06-08hr  (2674) embryo 08-10hr  1944 embryo 10-12hr    1132 embryo 12-14hr    1146 embryo 14-16hr    1088 embryo 16-18hr    660 embryo 18-20hr    648 embryo 20-22hr    443 embryo 22-24hr    392 larva L1    529 larva L2    417 larva L3 12hr old    402 larva L3 puffstage 1-2    500 larva L3 puffstage 3-6    1032 larva L3 puffstage 7-9    938 white prepupae new    883 white prepupae 12hr    1172 white prepupae 24hr  1791 pupae 2d postWPP    811 pupae 3d postWPP    497 pupae 4d postWPP    532 adult male 01day    674 adult male 05day    810 adult male 30day    927 adult female 01day    777 adult female 05day    875 adult female 30day    884 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1164 embryo 02-04hr    1071 embryo 04-06hr    2755 embryo 06-08hr    2674 embryo 08-10hr    1944 embryo 10-12hr    1132 embryo 12-14hr    1146 embryo 14-16hr    1088 embryo 16-18hr    660 embryo 18-20hr    648 embryo 20-22hr    443 embryo 22-24hr    392 larva L1    529 larva L2    417 larva L3 12hr old    402 larva L3 puffstage 1-2    500 larva L3 puffstage 3-6    1032 larva L3 puffstage 7-9    938 white prepupae new    883 white prepupae 12hr    1172 white prepupae 24hr    1791 pupae 2d postWPP    811 pupae 3d postWPP    497 pupae 4d postWPP    532 adult male 01day    674 adult male 05day    810 adult male 30day    927 adult female 01day    777 adult female 05day    875 adult female 30day    884 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1164 embryo 02-04hr    1071 embryo 04-06hr    2755 embryo 06-08hr    2674 embryo 08-10hr    1944 embryo 10-12hr    1132 embryo 12-14hr    1146 embryo 14-16hr    1088 embryo 16-18hr    660 embryo 18-20hr    648 embryo 20-22hr    443 embryo 22-24hr    392 larva L1    529 larva L2    417 larva L3 12hr old    402 larva L3 puffstage 1-2    500 larva L3 puffstage 3-6    1032 larva L3 puffstage 7-9    938 white prepupae new    883 white prepupae 12hr    1172 white prepupae 24hr    1791 pupae 2d postWPP    811 pupae 3d postWPP    497 pupae 4d postWPP    532 adult male 01day    674 adult male 05day    810 adult male 30day    927 adult female 01day    777 adult female 05day    875 adult female 30day    884 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0001324    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0001324 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0001324 expression level Tissue   Expression Level Larval Central Nervous System    139.875 Larval Midgut    46.4 Larval Hindgut    47.1 Larval Malpighian Tubules    64.4 Larval Fat Body    65.9 Larval Salivary Gland    85 Larval Trachea    95.475 Larval Carcass    60.8 Adult Head    43.5 Adult Eye    47.5 Adult Brain    84 Adult Thoracic-Abdominal Ganglion    73.7 Adult Crop    55.7 Adult Midgut    37.1 Adult Hindgut    43.5 Adult Malpighian Tubules    49.3 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    42.6 Adult VirginFemale Spermatheca    49.7 Adult InseminatedFemale Spermatheca    58 Adult Ovary    71.1 Adult Testis    187.7 Adult Male Accessory Gland    60.3 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    139.875 Larval Midgut    46.4 Larval Hindgut    47.1 Larval Malpighian Tubules    64.4 Larval Fat Body    65.9 Larval Salivary Gland    85 Larval Trachea    95.475 Larval Carcass    60.8 Adult Head    43.5 Adult Eye    47.5 Adult Brain    84 Adult Thoracic-Abdominal Ganglion    73.7 Adult Crop    55.7 Adult Midgut    37.1 Adult Hindgut    43.5 Adult Malpighian Tubules    49.3 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    42.6 Adult VirginFemale Spermatheca    49.7 Adult InseminatedFemale Spermatheca    58 Adult Ovary    71.1 Adult Testis    187.7 Adult Male Accessory Gland    60.3 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    139.875 Larval Midgut    46.4 Larval Hindgut    47.1 Larval Malpighian Tubules    64.4 Larval Fat Body    65.9 Larval Salivary Gland    85 Larval Trachea    95.475 Larval Carcass    60.8 Adult Head    43.5 Adult Eye    47.5 Adult Brain    84 Adult Thoracic-Abdominal Ganglion    73.7 Adult Crop    55.7 Adult Midgut    37.1 Adult Hindgut    43.5 Adult Malpighian Tubules    49.3 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    42.6 Adult VirginFemale Spermatheca    49.7 Adult InseminatedFemale Spermatheca    58 Adult Ovary    71.1 Adult Testis    187.7 Adult Male Accessory Gland    60.3 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    139.875 Larval Midgut    46.4 Larval Hindgut    47.1 Larval Malpighian Tubules    64.4 Larval Fat Body    65.9 Larval Salivary Gland    85 Larval Trachea    95.475 Larval Carcass    60.8 Adult Head    43.5 Adult Eye    47.5 Adult Brain    84 Adult Thoracic-Abdominal Ganglion    73.7 Adult Crop    55.7 Adult Midgut    37.1 Adult Hindgut    43.5 Adult Malpighian Tubules    49.3 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    42.6 Adult VirginFemale Spermatheca    49.7 Adult InseminatedFemale Spermatheca    58 Adult Ovary    71.1 Adult Testis    187.7 Adult Male Accessory Gland    60.3 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0001324 expression level Tissue   Expression Level Larval Central Nervous System    139.875 Larval Midgut    46.4 Larval Hindgut    47.1 Larval Malpighian Tubules    64.4 Larval Fat Body    65.9 Larval Salivary Gland    85 Larval Trachea    95.475 Larval Carcass    60.8 Adult Head    43.5 Adult Eye    47.5 Adult Brain    84 Adult Thoracic-Abdominal Ganglion    73.7 Adult Crop    55.7 Adult Midgut    37.1 Adult Hindgut    43.5 Adult Malpighian Tubules    49.3 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    42.6 Adult VirginFemale Spermatheca    49.7 Adult InseminatedFemale Spermatheca    58 Adult Ovary    71.1 Adult Testis    187.7 Adult Male Accessory Gland    60.3 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    139.875 Larval Midgut    46.4 Larval Hindgut    47.1 Larval Malpighian Tubules    64.4 Larval Fat Body    65.9 Larval Salivary Gland    85 Larval Trachea    95.475 Larval Carcass    60.8 Adult Head    43.5 Adult Eye    47.5 Adult Brain    84 Adult Thoracic-Abdominal Ganglion    73.7 Adult Crop    55.7 Adult Midgut    37.1 Adult Hindgut    43.5 Adult Malpighian Tubules    49.3 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    42.6 Adult VirginFemale Spermatheca    49.7 Adult InseminatedFemale Spermatheca    58 Adult Ovary    71.1 Adult Testis    187.7 Adult Male Accessory Gland    60.3 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    139.875 Larval Midgut    46.4 Larval Hindgut    47.1 Larval Malpighian Tubules    64.4 Larval Fat Body    65.9 Larval Salivary Gland    85 Larval Trachea    95.475 Larval Carcass    60.8 Adult Head    43.5 Adult Eye    47.5 Adult Brain    84 Adult Thoracic-Abdominal Ganglion    73.7 Adult Crop    55.7 Adult Midgut    37.1 Adult Hindgut    43.5 Adult Malpighian Tubules    49.3 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    42.6 Adult VirginFemale Spermatheca    49.7 Adult InseminatedFemale Spermatheca    58 Adult Ovary    71.1 Adult Testis    187.7 Adult Male Accessory Gland    60.3 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    139.875 Larval Midgut    46.4 Larval Hindgut    47.1 Larval Malpighian Tubules    64.4 Larval Fat Body    65.9 Larval Salivary Gland    85 Larval Trachea    95.475 Larval Carcass    60.8 Adult Head    43.5 Adult Eye    47.5 Adult Brain    84 Adult Thoracic-Abdominal Ganglion    73.7 Adult Crop    55.7 Adult Midgut    37.1 Adult Hindgut    43.5 Adult Malpighian Tubules    49.3 Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    42.6 Adult VirginFemale Spermatheca    49.7 Adult InseminatedFemale Spermatheca    58 Adult Ovary    71.1 Adult Testis    187.7 Adult Male Accessory Gland    60.3 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    43.5   NA  Eye    47.5   NA  Brain    84   139.875  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    73.7   NA  Crop    55.7   46.4  Midgut    37.1   47.1  Hindgut    43.5   64.4  Malpighian Tubules    49.3   65.9  Fat Body    no informative data   85  Salivary Gland    no informative data   NA  Heart    42.6   95.475  Trachea    NA   NA  VirginFemale Spermatheca    49.7   NA  InseminatedFemale Spermatheca    58   NA  Ovary    71.1   NA  Testis    187.7   NA  Male Accessory Gland    60.3   60.8  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_21
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001324 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8491-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | partially, with Scer\GAL4da.G32 ktoScer\UAS.cJa lethal | recessive kto1 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 ktoGD13207 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 ktoGD13207 visible, with Scer\GAL4vg.PM ktoScer\UAS.cJa visible | somatic clone kto32E16 kto33AC9 kto33AC20 kto33D19 kto144 kto1251 Phenotype manifest in Allele antennal disc ktoT241 ktoT555 ktoT631 eye | somatic clone - Minute background ktoT241 eye disc ktoT241 ktoT555 ktoT631 heart primordium ktodsRNA.cKa ktodsRNA.si.cKa leg | somatic clone - Minute background ktoT241 mesothoracic bristle | somatic clone ktoT241 mesothoracic bristle | somatic clone - Minute background ktoT241 mesothoracic tergum, with Scer\GAL4pnr-MD237 ktoGD13207 photoreceptor cell ktoT241 ktoT555 ktoT631 prothoracic tarsal segment | somatic clone ktoT241 sex comb tooth | somatic clone ktoT241 trichogen cell, with Scer\GAL4pnr-MD237 ktoGD13207 wing | somatic clone kto32E16 kto33D19 kto33AC9 kto33AC20 kto144 kto1251 wing disc | somatic clone ktoT241 ktounspecified wing disc | somatic clone, with Scer\GAL4αTub84B.PL ktoScer\UAS.cJa wing margin, with Scer\GAL4vg.PM ktoScer\UAS.cJa
Classical Alleles ( 14 )
For All Classical Alleles Show
Allele of kto Class Mutagen Stocks Known lesion kto1 hypomorphic allele - genetic evidence ethyl methanesulfonate 3 -- kto1251 ethyl methanesulfonate 0 -- kto12 0 -- kto144 ethyl methanesulfonate 0 -- kto32E16 ethyl methanesulfonate 0 -- kto33AC20 ethyl methanesulfonate 0 -- kto33AC9 ethyl methanesulfonate 0 -- kto33D19 ethyl methanesulfonate 0 -- kto3 0 -- ktoT241 ethyl methanesulfonate 0 Yes ktoT555 ethyl methanesulfonate 0 Yes ktoT631 ethyl methanesulfonate 0 Yes ktoT663 0 -- ktounspecified 0 --
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of kto Class Mutagen Stocks Known lesion ktoGD13207 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes ktoHMS01062 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ktoa.cKa in vitro construct - RNAi 0 Yes ktocKa in vitro construct - RNAi 0 Yes ktodsRNA.cKa in vitro construct - RNAi 0 Yes ktodsRNA.si.cKa in vitro construct - RNAi 0 Yes ktoNIG.8491R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes ktoScer\UAS.cJa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)25-21 (Veraksa et al., 2002, de Ayala Alonso et al., 2007, Cooper et al., 2010) Df(3L)A23 (Cooper et al., 2010) Df(3L)ash1A16 (Cooper et al., 2010) Df(3L)BSC2 (Bloomington Drosophila Stock Center, 1999.2.23, de Ayala Alonso et al., 2007, Cooper et al., 2010) Df(3L)BSC445 (Christensen et al., 2008.4.15, Cooper et al., 2010) Df(3L)BSC552 (Christensen et al., 2008.7.11) Df(3L)ED228 (de Ayala Alonso et al., 2007, Cooper et al., 2010) Df(3L)ED229 (de Ayala Alonso et al., 2007) Df(3L)Exel9007 (Cooper et al., 2010) Df(3L)Exel9008 (Cooper et al., 2010) Df(3L)Exel9009 (Cooper et al., 2010) Df(3L)kto2 (Veraksa et al., 2002, Zhu et al., 2005, Gross and McGinnis, 1996, Cooper et al., 2010) Df(3L)kto22 (Cooper et al., 2010) Df(3L)XS411 (de Ayala Alonso et al., 2007, Cooper et al., 2010) Df(3L)XS533 (Cooper et al., 2010) Df(3L)XS543 (Cooper et al., 2010) Df(3L)XS572 (de Ayala Alonso et al., 2007, Cooper et al., 2010) Df(3L)XS705 (de Ayala Alonso et al., 2007, Cooper et al., 2010) Df(3L)XS917 (Cooper et al., 2010) Df(3L)XS2182 (Cooper et al., 2010)
Not disrupted in	Df(3L)BSC1 (Bloomington Drosophila Stock Center, 1999.2.23) Df(3L)BSC20 (Cooper et al., 2010) Df(3L)BSC417 (Cooper et al., 2010) Df(3L)ED4799 (Cooper et al., 2010) Df(3L)ED4858 (Cooper et al., 2010) Df(3L)Exel6135 (Cooper et al., 2010) Df(3L)Exel9011 (Cooper et al., 2010) Df(3L)Exel9045 (Cooper et al., 2010) Df(3L)Exel9046 (Cooper et al., 2010) Df(3L)pipeA13 (Cooper et al., 2010)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD13207} NA P{TRiP.HMS01062} NA P{UAS-kto.J} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
Terms Based on Experimental Evidence ( 9 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with UniProtKB:P25008 (assigned by UniProtKB) (Loncle et al., 2007) inferred from physical interaction with UniProtKB:Q7KTX8 (assigned by UniProtKB) (Janody et al., 2003) inferred from physical interaction with UniProtKB:Q9VT57 (assigned by UniProtKB) (Loncle et al., 2007) RNA polymerase II transcription cofactor activity inferred from direct assay (assigned by UniProtKB) (Janody et al., 2003)
Biological Process
CV term Evidence References
chaeta development inferred from mutant phenotype (Loncle et al., 2007) compound eye development inferred from mutant phenotype (Loncle et al., 2007) imaginal disc-derived leg segmentation inferred from mutant phenotype (Loncle et al., 2007) positive regulation of Wnt receptor signaling pathway inferred from mutant phenotype (Carrera et al., 2008) regulation of transcription from RNA polymerase II promoter inferred from direct assay (assigned by UniProtKB) (Janody et al., 2003) sex comb development inferred from mutant phenotype (Loncle et al., 2007)
Cellular Component
CV term Evidence References
mediator complex inferred from direct assay (assigned by UniProtKB) (Janody et al., 2003) inferred from physical interaction with Cdk8, CycC (Loncle et al., 2007)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
RNA polymerase II transcription cofactor activity inferred from sequence or structural similarity (Boube et al., 2000) non-traceable author statement (FlyBase, 1992-)
Biological Process
CV term Evidence References
transcription from RNA polymerase II promoter non-traceable author statement (FlyBase, 1992-) transcription initiation from RNA polymerase II promoter inferred from sequence or structural similarity (Boube et al., 2000)
Cellular Component
CV term Evidence References
mediator complex inferred from sequence or structural similarity (Boube et al., 2000) non-traceable author statement (FlyBase, 1992-) nucleus non-traceable author statement (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions kto allele Gene References kto1 BEAF-32 (Yamaguchi et al., 2001) corto (Lopez et al., 2001) CycE (Brumby et al., 2002) E(z) (Bajusz et al., 2001) Kr (Sollars et al., 2003) os (Bach et al., 2003) Pc (Kennison and Tamkun, 1988) ktoScer\UAS.cJa skd (Janody et al., 2003) unspecified Antp (Kennison and Tamkun, 1988) ph-p (Fauvarque et al., 1995)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 69311 DroID - A comprehensive database of gene and protein interactions. • FBgn0001324 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44830
Orthologs
Genome-wide drosophilid orthologs	Dana\GF23597 Dere\GG16062 Dgri\GH14662 Dmoj\GI11646 Dper\GL15740 Dpse\GA21114 Dsec\GM19665 Dsim\GD14832 Dvir\GJ11327 Dwil\GK16973 Dyak\GE19628
Curated drosophilid orthologs	Dmir\CG8491 (Thornton, 2005.12.20) Dpse\GA21114
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL008244-PA Aedes aegypti (mosquito) AGAP002523-PA Anopheles gambiae (mosquito) XP_392792.3 Apis mellifera (honey bee) XP_001944097.1 Acyrthosiphon pisum (pea aphid) 119555 Branchiostoma floridae (lancelet) XP_001895971.1 Brugia malayi (roundworm nematode) BGIBMGA007554-PA Bombyx mori (silk worm) ENSBTAP00000028464 Bos taurus (bovine) CN11338 Caenorhabditis brenneri (small nematode) CBP35577 Caenorhabditis briggsae (nematode) CE16058 Caenorhabditis elegans (worm) ENSCAFP00000012501 Canis familiaris (dog) ENSCINP00000014897 Ciona intestinalis (sea squirt) JA02538 Caenorhabditis japonica (nematode) CPIJ013223 Culex pipens (mosquito) ENSCPOP00000000814 Cavia porcellus (guinea pig) RP49218 Caenorhabditis remanei (nematode) ENSCSAVP00000008003 Ciona savignyi (sedentary tunicate) 163894 Capitella spl (polychaete worm) 202343 Daphnia pulex (daphnia) ENSDARP00000073783 Danio rerio (zebra fish) ENSECAP00000005269 Equus caballus (horse) ENSGACP00000023116 Gymnopilus aculeatus (mushroom) ENSGALP00000009011 Gallus gallus (chicken) 105468 Hypsipyla robusta (cedar shoot borer) ENSP00000273432 Homo sapiens (human) ISCW006114-PA Ixodes scapularis (deer tick) 130112 Lottia gigantea (owl limpet) ENSMODP00000026599 Monodelphis domestica (gray opossum) ENSMMUP00000022674 Macaca mulatta (rhesus monkey) ENSMUSP00000042269 Mus musculus (house mouse) ENSORLP00000000975 Oryzias latipes (japanese killifish) PHUM003866-PA Pediculus humanus (human body louse) ENSPPYP00000015891 Pongo pygmaeus (orangutan) ENSPTRP00000026746 Pan troglodytes (chimpanzee) ENSRNOP00000014494 Rattus norvegicus (norway rat) Smp_166410 Schistosoma mansoni (trematode parasite) XP_967984.2 Tribolium castaneum (red flour beetle) ENSTNIP00000018822 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000032004 Takifugu rubripes (pufferfish Takifugu) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV50215 LH16113 ISCW006114 FBgn0236966 FBgn0218972 FBgn0198587 FBgn0186505 FBgn0174565 JGI_V11_202343 FBgn0081102 FBgn0153344 FBgn0134406 FBgn0122138 FBgn0108297 FBgn0100591 CPIJ013223 BGIBMGA007554 ACYPI010217 GB10810 AGAP002523 AAEL008244 PB19896 PHUM489830 GLEAN_14560
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	3618 kto1 ca1/TM6B, Tb1 34588 y1 sc* v1; P{TRiP.HMS01062}attP2
Kyoto	107132 kto1 ca1/TM6B, Tb1 101675 kto1 ca1 / TM6B, Tb1
VDRC	v23142 w1118; P{GD13207}v23142 v23143 w1118; P{GD13207}v23143
Genomic Clones ( 2 )
	BACR01B21 BACR13N10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 12 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT01988 SD08305
Other clones	FI11065
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT04615 AT20674 AT23094 AT23621 LP12010 LP16008
Other clones	99675 AT26191 EK222323
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0001324 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44830
Antibody Information
	polyclonal (Janody et al., 2003)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: kto CG8491 (FlyBase, 1996-)
Additional comments	Source for merge of kto CG8491 was sequence comparison (date:010116). (FlyBase, 1996-)
Other Comments
	Both skd and kto are required to establish normal cell affinity differences at the anterior-posterior and dorsal-ventral compartment boundaries of the wing disc. (Janody et al., 2003) skd and kto seem to act together to promote specific cell fate decisions, transmitting either a novel signal or a combination of signals. (Treisman, 2001) Sections of the Scr regulatory region may be important for regulation of Scr by Polycomb- and trithorax-group genes. (Gindhart and Kaufman, 1995) kto is one of the 18 loci identified in a screen for dominant modifiers of Pc and/or Antp phenotypes. Alleles of Pc, Pcl, Scm, Dll, brm, kto, Scr and trx show clear dominant enhancement or suppression of AntpScx, whereas alleles of vtd, Vha55, Su(Pc)37D, urd, mor, skd and osa do not. (Kennison and Tamkun, 1988)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080047 RefSeq (Proteins) • NP_524786 DDBJ / EMBL / GenBank • AAF49103 AAG48328 AAM52769 AF324426 AI542171 AY122257 Entrez Gene - A searchable database of RefSeq genes. • 44830 UniProtKB/TrEMBL • Q9VW47
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Mediator complex, subunit Med12 (IPR019035) Mediator complex, subunit Med12, LCEWAV-domain (IPR021990)
Linkouts
	BioGRID - A database of protein and genetic interactions • 69311 DroID - A comprehensive database of gene and protein interactions. • FBgn0001324 DRSC - Results from RNAi screens. • FBgn0001324 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001324 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8491-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0001324 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44830 InParanoid A subset of ortholog calls from InParanoid. • AAEL008244-PA Aedes aegypti (mosquito) AGAP002523-PA Anopheles gambiae (mosquito) XP_392792.3 Apis mellifera (honey bee) XP_001944097.1 Acyrthosiphon pisum (pea aphid) 119555 Branchiostoma floridae (lancelet) XP_001895971.1 Brugia malayi (roundworm nematode) BGIBMGA007554-PA Bombyx mori (silk worm) ENSBTAP00000028464 Bos taurus (bovine) CN11338 Caenorhabditis brenneri (small nematode) CBP35577 Caenorhabditis briggsae (nematode) CE16058 Caenorhabditis elegans (worm) ENSCAFP00000012501 Canis familiaris (dog) ENSCINP00000014897 Ciona intestinalis (sea squirt) JA02538 Caenorhabditis japonica (nematode) CPIJ013223 Culex pipens (mosquito) ENSCPOP00000000814 Cavia porcellus (guinea pig) RP49218 Caenorhabditis remanei (nematode) ENSCSAVP00000008003 Ciona savignyi (sedentary tunicate) 163894 Capitella spl (polychaete worm) 202343 Daphnia pulex (daphnia) ENSDARP00000073783 Danio rerio (zebra fish) ENSECAP00000005269 Equus caballus (horse) ENSGACP00000023116 Gymnopilus aculeatus (mushroom) ENSGALP00000009011 Gallus gallus (chicken) 105468 Hypsipyla robusta (cedar shoot borer) ENSP00000273432 Homo sapiens (human) ISCW006114-PA Ixodes scapularis (deer tick) 130112 Lottia gigantea (owl limpet) ENSMODP00000026599 Monodelphis domestica (gray opossum) ENSMMUP00000022674 Macaca mulatta (rhesus monkey) ENSMUSP00000042269 Mus musculus (house mouse) ENSORLP00000000975 Oryzias latipes (japanese killifish) PHUM003866-PA Pediculus humanus (human body louse) ENSPPYP00000015891 Pongo pygmaeus (orangutan) ENSPTRP00000026746 Pan troglodytes (chimpanzee) ENSRNOP00000014494 Rattus norvegicus (norway rat) Smp_166410 Schistosoma mansoni (trematode parasite) XP_967984.2 Tribolium castaneum (red flour beetle) ENSTNIP00000018822 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000032004 Takifugu rubripes (pufferfish Takifugu) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44830 modMine - Data generated by the modENCODE project. • FBgn0001324 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV50215 LH16113 ISCW006114 FBgn0236966 FBgn0218972 FBgn0198587 FBgn0186505 FBgn0174565 JGI_V11_202343 FBgn0081102 FBgn0153344 FBgn0134406 FBgn0122138 FBgn0108297 FBgn0100591 CPIJ013223 BGIBMGA007554 ACYPI010217 GB10810 AGAP002523 AAEL008244 PB19896 PHUM489830 GLEAN_14560
Synonyms & Secondary IDs ( 17 )
Reported As
Symbol Synonym	CG8491 (Kim et al., 2004, Boube et al., 2000, Holloway et al., 2008, Gim et al., 2001, Ni et al., 2010.12.1) dTRAP230 (Park et al., 2001, Boube et al., 2000) dTrap230 (Gim et al., 2001) Kto (Bourbon et al., 2004, Guglielmi et al., 2004, Lim et al., 2007) kto (Holloway et al., 2008, Christensen et al., 2008.7.11, Hirose et al., 2001, Christensen et al., 2008.4.15, de Ayala Alonso et al., 2007, Vázquez et al., 2008, Petruk et al., 2008, Carrera et al., 2008, Saj et al., 2010, Cooper et al., 2010, Bhatia et al., 2010, Wasbrough et al., 2010) Kto/Med12 (Loncle et al., 2005) l(3)76BDc (Cooper et al., 2010) MED12 (Kim et al., 2004, Bourbon et al., 2004, Kim and Lis, 2005, Stadeli, 2006) Med12 (Kim et al., 2004, Kim and Lis, 2005, Loncle et al., 2007, Gobert et al., 2010) med12/kto (Terriente-Félix et al., 2010) siren1 (de Ayala Alonso et al., 2007) SRB8 (Boube et al., 2000) Srb8/KTO/TRAP230 (Boube et al., 2002) Trap230 (Johnson et al., 2001, Kim and Lis, 2005)
Name Synonym	khotalo (Sollars et al., 2003) kohtalo (Kim and Lis, 2005, Lim et al., 2007, Carrera et al., 2008) Mediator complex subunit 12 (Bourbon et al., 2004)
Secondary FlyBase IDs
	FBgn0036912
References ( 86 )
Generate a list of	All references relating to this gene ( 86 )
List References by type	Research paper  ( 49 ) Supplementary material  ( 3 ) Review  ( 8 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 13 ) FlyBase analysis  ( 2 ) Letter  ( 1 ) DNA/RNA sequence record  ( 2 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 5 )
	Bhatia et al., 2010, Genes Cells 15(7): 725--735 Chromatin remodeling protein INO80 has a role in regulation of homeotic gene expression in Drosophila. [FBrf0211277] Cooper et al., 2010, Genetics 185(3): 811--822 Molecular Genetic Analysis of Chd3 and Polytene Chromosome Region 76B-D in Drosophila melanogaster. [FBrf0211329] Gobert et al., 2010, Mol. Cell. Biol. 30(11): 2837--2848 A genome-wide RNA interference screen identifies a differential role of the mediator CDK8 module subunits for GATA/ RUNX-activated transcription in drosophila. [FBrf0210768] Saj et al., 2010, Dev. Cell 18(5): 862--876 A combined ex vivo and in vivo RNAi screen for notch regulators in Drosophila reveals an extensive notch interaction network. [FBrf0210834] Terriente-Félix et al., 2010, Genetics 185(2): 671--684 Identification of genes affecting wing patterning through a loss-of-function mutagenesis screen and characterization of med15 function during wing development. [FBrf0211230] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...