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Gene Dmel\egh

General Information
Symbol	Dmel\egh	Species	D. melanogaster
Name	egghead	Annotation symbol	CG9659
Feature type	protein_coding_gene	FlyBase ID	FBgn0001404
Gene Model Status	Current	Stock availability	12 publicly available
Also Known As	zw4, l(1)zw4, zw-4, EG:BACR25B3.8
Genomic Location
Chromosome (arm)	X	Recombination map	1-1.2
Cytogenetic map	3A6-3A6	Sequence location	X:2,482,536..2,493,144 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene egghead is referred to in FlyBase by the symbol Dmel\egh (CG9659, FBgn0001404). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: beta-1,4-mannosyltransferase activity. There is experimental evidence for 16 unique biological process terms, many of which group under: single-organism developmental process; multicellular organism reproduction; localization; cellular component organization or biogenesis; biological regulation; ovarian follicle cell development; gamete generation; multi-organism reproductive process; mating; cell fate commitment; establishment or maintenance of polarity of follicular epithelium; nitrogen compound transport. 60 alleles are reported. The phenotypes of these alleles are annotated with: organ system; organ system subdivision; adult segment; larval head segment; sense organ; portion of tissue; external compound sense organ; region of integument; epithelial cell; cell cluster organ. It has 3 annotated transcripts and 3 annotated polypeptides. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, larval fat body, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Gene sequence location is X:2482536..2493144.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	l(1)3Ae Alleles tested [l(1)Ae2, l(1)Ae3, l(1)Ae6, l(1)Ae8, l(1)Ae10, l(1)Ae11] die in post puparial stage, but growth slowing starts at various earlier stages; tested alleles survive in hemizygous condition in gynandromorphs; hemizygous eyes rough. Pharate adults dissected from l(1)3Ae1 and l(1)Ae5 pupae show rough eyes, sparse microchaetae, and incomplete dorsal midline; XY but not XO males of both rescued by Dp(1;4)wm65g, exhibiting phenotype of dissected pharate adults described above (Shannon, Kaufman, Shen, and Judd, l972, Genetics 72: 615-38).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03	Alleles egh[C502a]
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 3A6-3A6   Limits computationally determined from genome sequence between P{EP}CG32796EP1385&P{EP}EP1160 and P{EP}eghEP804
Experimentally Determined Cytological Location
Cytogenetic map Notes References 3A8-3A8     (Hollmann, 2000.2.9) 3A5-3A8   (determined by in situ hybridisation)   (Endow and Hatsumi, 1991)
Experimentally Determined Recombination Data
Location	1-1.2
Left of (cM)
Right of (cM)	wds (Judd et al., 1972)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\egh for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) egh-RB FBtr0070440  NM_166946   3303   457 egh-RC FBtr0070439  NM_080313   3595   457 egh-RD FBtr0340091     2946   457
Additional Transcript Data & Comments
Reported size (kB)	3.7 (northern blot) (Goode et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein egh-PB   FBpp0070424   52.0   457   8.09     NP_726818   AAF45792 egh-PC   FBpp0070423   52.0   457   8.09     NP_525052   AAN09081 egh-PD   FBpp0309090   52.0   457   8.09
Additional Polypeptide Data & Comments
Reported size (kDa)	457 (aa); 52 (kD predicted) (Goode et al., 1996)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Beta-1,4-mannosyltransferase Bre-3/Egh (IPR027389)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014298 AAF45792   AE014298 AAN09081   AF233288 AAF43419   AI062041   AI106667   AI258743   AL138972 CAB72293   AW940094   AY060595 AAL28143   BI166219   BI215246   BI230402   BI234058   BI240830   BI615382   BI626989   BP546181   BT053741   BT071797   BT082051   BT133075   CO156728   CO178826   CO273223   CO337119   CZ473504   DN154421   EC071918   EC081834   EC089319   EC198882   EC241703   EC248845   EC263290   EC263338   EV588155   EV597829   GH748837   GH749413   GH749657   GH751829   GH752438   GH754327   GH755021   GH755616   GH756174   GH757142   GH758224   GH758281   GH759082   GH759288   GH760166   GH760186   GH760292   GH771664   GH772185   GH772654   GH772845   GH773192   GH774486   GH777074   GH777855   GH780021   GH780252   GH780317   GH780779   GH780947   GH781234   GH781811   GH782089   GH782237   GH782685   GH782923   GH784860   GH786359   GH786591   GH787556   GH788155   GH788266   GH788632   GH791173   GH792966   GH793304   GH793890   GH794022   GH794285   GH794929   GH796084   GH798237   GH799091   GH799284   GH799866   GH801132   GH802038   GH803455   GH806044   GH807326   GH807704   GH810631   GH810817   GH811522   GH811741   GH814549   GH815108   GH815654   GH815998   GH816444   GH816862   GH818026   GH818731   GH818920   GH819196   GH819892   GH820317   GH823429   GH824412   GH829776   GH832277   GH833342   GH834056   GH834230   GH835735   GH839927   GH841234   GH842482   GH844619   GH844620   GH847949   GH848254   GH850191   GH850462   GH850610   GH850639   GH850916   GH851408   GH851519   GH852760   GH853047   GH853507   GH854248   GH854488   GH858234   GH859419   GH859673   GH860925   GH861026   GH862288   GH862403   GH864990   GH865269   GH865308   GH866085   GH866604   GH866823   GH867259   GH868554   GH869300   GH873415   GH873990   GH875679   GH877250   GH877484   GH877839   GH878653   GH879125   GH879247   GH879417   GH880382   GH881517   GH883476   GH883716   GH886491   GH886784   GH887151   GH887596   GH889164   GH890131   GH890430   GH890628   GH890694   GH891079   GH891675   GH895358   GH896088   GH896346   GH896845   GH897404   GH898368   GH899058   GH899262   GH899526   GH899599   GH899691   GH900311   GH900773   GH901290   GH902076   GH902384   GH906945   GH906984   GH907856   GH907931   GH909141   GH910697   GH911231   GH914203   GH916771   GH916826   GH917761   GH918369   GH918517   GH919620   GH920520   GH921207   GH921510   GH921706   GH921867   GH922066   GH922176   GH924632   GH924842   GH925112   GH926056   GH927612   GH927709   GH927779   GH928635   GH928834   GH929138   GH929549   GH929978   GH930960   GH932769   GH934675   GH934748   GH934825   GH935121   GH935498   GH935752   GH935908   GH936542   GH936765   GH936948   GH937507   GH937600   GH937950   GH942551   U15602 AAB49734   U21218 AAB49735
UniProtKB/Swiss-Prot	O01346
UniProtKB/TrEMBL	A4V3W0 Q95ST6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 4     (Goode et al., 1996) Comment:reference states 0-2 hr AEL adult stage | female & oogenesis   germarium region 2b & germline cell   (Goode et al., 1996) germarium region 2a & germline cell   (Goode et al., 1996) adult stage & oogenesis stage S10   nurse cell   (Goode et al., 1996)
Additional Descriptive Data
	The in-situ localization of egh transcript is consistent with the proposed role of egh in epithelial morphogenesis during oogenesis. egh transcript is first detected during oogenesis in germ cells at the junction of germarium regions 2a and 2b. From stage S4 to S9, the egh transcript differentially accumulates in the oocyte. At stage S10, egh transcript expression declines in oocytes but increases in nurse cells. Subsequently, the content of nurse cells is transferred to oocytes. Northern analysis shows that the egh transcript is present in 0-2 hour embryos. (Goode et al., 1996)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: adult eye, larval Malpighian tubules. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, larval fat body, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    33 central nervous system, pupae P8    48 head, virgin 1-day female    25 head, virgin 4-day female    28 head, virgin 20-day female    15 head, mated 1-day female    30 head, mated 4-day female    27 head, mated 20-day female    17 head, mated 1-day male    35 head, mated 4-day male    41 head, mated 20-day male    34 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    64 digestive system, 1-day adult    53 digestive system, 4-day adult    77 digestive system, 20-day adult    49 fat body, larvae L3 wandering    19 fat body, white prepupae    16 fat body, pupae P8    24 carcass, larvae L3 wandering    28 carcass, 1-day adult    28 carcass, 4-day adult    30 carcass, 20-day adult    24 ovary, virgin 4-day female    58 ovary, mated 4-day female    66 testis, mated 4-day male    7 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3  (33) central nervous system, pupae P8  (48) head, virgin 1-day female    25 head, virgin 4-day female  (28) head, virgin 20-day female    15 head, mated 1-day female  (30) head, mated 4-day female  (27) head, mated 20-day female    17 head, mated 1-day male  (35) head, mated 4-day male  (41) head, mated 20-day male  (34) salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    14 digestive system, larvae L3 wandering  (64) digestive system, 1-day adult  (53) digestive system, 4-day adult  (77) digestive system, 20-day adult  (49) fat body, larvae L3 wandering    19 fat body, white prepupae    16 fat body, pupae P8    24 carcass, larvae L3 wandering  (28) carcass, 1-day adult  (28) carcass, 4-day adult  (30) carcass, 20-day adult    24 ovary, virgin 4-day female  (58) ovary, mated 4-day female  (66) testis, mated 4-day male    7 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    33 central nervous system, pupae P8    48 head, virgin 1-day female    25 head, virgin 4-day female    28 head, virgin 20-day female    15 head, mated 1-day female    30 head, mated 4-day female    27 head, mated 20-day female    17 head, mated 1-day male    35 head, mated 4-day male    41 head, mated 20-day male    34 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    64 digestive system, 1-day adult    53 digestive system, 4-day adult    77 digestive system, 20-day adult    49 fat body, larvae L3 wandering    19 fat body, white prepupae    16 fat body, pupae P8    24 carcass, larvae L3 wandering    28 carcass, 1-day adult    28 carcass, 4-day adult    30 carcass, 20-day adult    24 ovary, virgin 4-day female    58 ovary, mated 4-day female    66 testis, mated 4-day male    7 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    33 central nervous system, pupae P8    48 head, virgin 1-day female    25 head, virgin 4-day female    28 head, virgin 20-day female    15 head, mated 1-day female    30 head, mated 4-day female    27 head, mated 20-day female    17 head, mated 1-day male    35 head, mated 4-day male    41 head, mated 20-day male    34 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    64 digestive system, 1-day adult    53 digestive system, 4-day adult    77 digestive system, 20-day adult    49 fat body, larvae L3 wandering    19 fat body, white prepupae    16 fat body, pupae P8    24 carcass, larvae L3 wandering    28 carcass, 1-day adult    28 carcass, 4-day adult    30 carcass, 20-day adult    24 ovary, virgin 4-day female    58 ovary, mated 4-day female    66 testis, mated 4-day male    7 accessory gland, mated 4-day male    15 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    33 central nervous system, pupae P8    48 head, virgin 1-day female    25 head, virgin 4-day female    28 head, virgin 20-day female    15 head, mated 1-day female    30 head, mated 4-day female    27 head, mated 20-day female    17 head, mated 1-day male    35 head, mated 4-day male    41 head, mated 20-day male    34 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    64 digestive system, 1-day adult    53 digestive system, 4-day adult    77 digestive system, 20-day adult    49 fat body, larvae L3 wandering    19 fat body, white prepupae    16 fat body, pupae P8    24 carcass, larvae L3 wandering    28 carcass, 1-day adult    28 carcass, 4-day adult    30 carcass, 20-day adult    24 ovary, virgin 4-day female    58 ovary, mated 4-day female    66 testis, mated 4-day male    7 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3  (33) central nervous system, pupae P8  (48) head, virgin 1-day female    25 head, virgin 4-day female  28 head, virgin 20-day female    15 head, mated 1-day female  30 head, mated 4-day female  27 head, mated 20-day female    17 head, mated 1-day male  (35) head, mated 4-day male  (41) head, mated 20-day male  (34) salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    14 digestive system, larvae L3 wandering  (64) digestive system, 1-day adult  (53) digestive system, 4-day adult  (77) digestive system, 20-day adult  (49) fat body, larvae L3 wandering    19 fat body, white prepupae    16 fat body, pupae P8    24 carcass, larvae L3 wandering  28 carcass, 1-day adult  28 carcass, 4-day adult  30 carcass, 20-day adult    24 ovary, virgin 4-day female  (58) ovary, mated 4-day female  (66) testis, mated 4-day male    7 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    33 central nervous system, pupae P8    48 head, virgin 1-day female    25 head, virgin 4-day female    28 head, virgin 20-day female    15 head, mated 1-day female    30 head, mated 4-day female    27 head, mated 20-day female    17 head, mated 1-day male    35 head, mated 4-day male    41 head, mated 20-day male    34 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    64 digestive system, 1-day adult    53 digestive system, 4-day adult    77 digestive system, 20-day adult    49 fat body, larvae L3 wandering    19 fat body, white prepupae    16 fat body, pupae P8    24 carcass, larvae L3 wandering    28 carcass, 1-day adult    28 carcass, 4-day adult    30 carcass, 20-day adult    24 ovary, virgin 4-day female    58 ovary, mated 4-day female    66 testis, mated 4-day male    7 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    15 central nervous system, larvae L3    33 central nervous system, pupae P8    48 head, virgin 1-day female    25 head, virgin 4-day female    28 head, virgin 20-day female    15 head, mated 1-day female    30 head, mated 4-day female    27 head, mated 20-day female    17 head, mated 1-day male    35 head, mated 4-day male    41 head, mated 20-day male    34 salivary gland, larvae L3 wandering    5 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    64 digestive system, 1-day adult    53 digestive system, 4-day adult    77 digestive system, 20-day adult    49 fat body, larvae L3 wandering    19 fat body, white prepupae    16 fat body, pupae P8    24 carcass, larvae L3 wandering    28 carcass, 1-day adult    28 carcass, 4-day adult    30 carcass, 20-day adult    24 ovary, virgin 4-day female    58 ovary, mated 4-day female    66 testis, mated 4-day male    7 accessory gland, mated 4-day male    15 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr    29 embryo 04-06hr    21 embryo 06-08hr    19 embryo 08-10hr    21 embryo 10-12hr    15 embryo 12-14hr    26 embryo 14-16hr    28 embryo 16-18hr    26 embryo 18-20hr    19 embryo 20-22hr    25 embryo 22-24hr    31 larva L1    19 larva L2    15 larva L3 12hr old    13 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    32 white prepupae new    31 white prepupae 12hr    44 white prepupae 24hr    25 pupae 2d postWPP    21 pupae 3d postWPP    13 pupae 4d postWPP    12 adult male 01day    20 adult male 05day    22 adult male 30day    24 adult female 01day    23 adult female 05day    31 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (45) embryo 02-04hr  (29) embryo 04-06hr    21 embryo 06-08hr    19 embryo 08-10hr    21 embryo 10-12hr    15 embryo 12-14hr  26 embryo 14-16hr  (28) embryo 16-18hr  26 embryo 18-20hr    19 embryo 20-22hr    25 embryo 22-24hr  (31) larva L1    19 larva L2    15 larva L3 12hr old    13 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9  (32) white prepupae new  (31) white prepupae 12hr  (44) white prepupae 24hr    25 pupae 2d postWPP    21 pupae 3d postWPP    13 pupae 4d postWPP    12 adult male 01day    20 adult male 05day    22 adult male 30day    24 adult female 01day    23 adult female 05day  (31) adult female 30day  (31) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr    29 embryo 04-06hr    21 embryo 06-08hr    19 embryo 08-10hr    21 embryo 10-12hr    15 embryo 12-14hr    26 embryo 14-16hr    28 embryo 16-18hr    26 embryo 18-20hr    19 embryo 20-22hr    25 embryo 22-24hr    31 larva L1    19 larva L2    15 larva L3 12hr old    13 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    32 white prepupae new    31 white prepupae 12hr    44 white prepupae 24hr    25 pupae 2d postWPP    21 pupae 3d postWPP    13 pupae 4d postWPP    12 adult male 01day    20 adult male 05day    22 adult male 30day    24 adult female 01day    23 adult female 05day    31 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr    29 embryo 04-06hr    21 embryo 06-08hr    19 embryo 08-10hr    21 embryo 10-12hr    15 embryo 12-14hr    26 embryo 14-16hr    28 embryo 16-18hr    26 embryo 18-20hr    19 embryo 20-22hr    25 embryo 22-24hr    31 larva L1    19 larva L2    15 larva L3 12hr old    13 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    32 white prepupae new    31 white prepupae 12hr    44 white prepupae 24hr    25 pupae 2d postWPP    21 pupae 3d postWPP    13 pupae 4d postWPP    12 adult male 01day    20 adult male 05day    22 adult male 30day    24 adult female 01day    23 adult female 05day    31 adult female 30day    31 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr    29 embryo 04-06hr    21 embryo 06-08hr    19 embryo 08-10hr    21 embryo 10-12hr    15 embryo 12-14hr    26 embryo 14-16hr    28 embryo 16-18hr    26 embryo 18-20hr    19 embryo 20-22hr    25 embryo 22-24hr    31 larva L1    19 larva L2    15 larva L3 12hr old    13 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    32 white prepupae new    31 white prepupae 12hr    44 white prepupae 24hr    25 pupae 2d postWPP    21 pupae 3d postWPP    13 pupae 4d postWPP    12 adult male 01day    20 adult male 05day    22 adult male 30day    24 adult female 01day    23 adult female 05day    31 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (45) embryo 02-04hr  29 embryo 04-06hr    21 embryo 06-08hr    19 embryo 08-10hr    21 embryo 10-12hr    15 embryo 12-14hr  26 embryo 14-16hr  28 embryo 16-18hr  26 embryo 18-20hr    19 embryo 20-22hr    25 embryo 22-24hr  31 larva L1    19 larva L2    15 larva L3 12hr old    13 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9  32 white prepupae new  31 white prepupae 12hr  (44) white prepupae 24hr    25 pupae 2d postWPP    21 pupae 3d postWPP    13 pupae 4d postWPP    12 adult male 01day    20 adult male 05day    22 adult male 30day    24 adult female 01day    23 adult female 05day  31 adult female 30day  31 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr    29 embryo 04-06hr    21 embryo 06-08hr    19 embryo 08-10hr    21 embryo 10-12hr    15 embryo 12-14hr    26 embryo 14-16hr    28 embryo 16-18hr    26 embryo 18-20hr    19 embryo 20-22hr    25 embryo 22-24hr    31 larva L1    19 larva L2    15 larva L3 12hr old    13 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    32 white prepupae new    31 white prepupae 12hr    44 white prepupae 24hr    25 pupae 2d postWPP    21 pupae 3d postWPP    13 pupae 4d postWPP    12 adult male 01day    20 adult male 05day    22 adult male 30day    24 adult female 01day    23 adult female 05day    31 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr    29 embryo 04-06hr    21 embryo 06-08hr    19 embryo 08-10hr    21 embryo 10-12hr    15 embryo 12-14hr    26 embryo 14-16hr    28 embryo 16-18hr    26 embryo 18-20hr    19 embryo 20-22hr    25 embryo 22-24hr    31 larva L1    19 larva L2    15 larva L3 12hr old    13 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    19 larva L3 puffstage 7-9    32 white prepupae new    31 white prepupae 12hr    44 white prepupae 24hr    25 pupae 2d postWPP    21 pupae 3d postWPP    13 pupae 4d postWPP    12 adult male 01day    20 adult male 05day    22 adult male 30day    24 adult female 01day    23 adult female 05day    31 adult female 30day    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    27 Schneider line 2 Sg4    20 embryonic 1182-4H    55 embryonic GM2    24 embryonic Kc167    21 embryonic S1    38 embryonic S3    30 leg disc CME L1    24 wing disc CME-W2    61 wing disc ML-DmD8    33 wing disc ML-DmD9    72 wing disc ML-DmD16-c3    52 wing disc ML-DmD21    10 wing disc ML-DmD32    113 haltere disc ML-DmD17-c3    30 eye-antennal disc ML-DmD11    126 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    26 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    95 ovary fGS/OSS    16 ovary OSC    26 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (27) Schneider line 2 Sg4    20 embryonic 1182-4H  (55) embryonic GM2    24 embryonic Kc167    21 embryonic S1  (38) embryonic S3  (30) leg disc CME L1    24 wing disc CME-W2  (61) wing disc ML-DmD8  (33) wing disc ML-DmD9  (72) wing disc ML-DmD16-c3  (52) wing disc ML-DmD21    10 wing disc ML-DmD32  (113) haltere disc ML-DmD17-c3  (30) eye-antennal disc ML-DmD11  (126) antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1  26 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2  (95) ovary fGS/OSS    16 ovary OSC  26 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    27 Schneider line 2 Sg4    20 embryonic 1182-4H    55 embryonic GM2    24 embryonic Kc167    21 embryonic S1    38 embryonic S3    30 leg disc CME L1    24 wing disc CME-W2    61 wing disc ML-DmD8    33 wing disc ML-DmD9    72 wing disc ML-DmD16-c3    52 wing disc ML-DmD21    10 wing disc ML-DmD32  (113) haltere disc ML-DmD17-c3    30 eye-antennal disc ML-DmD11  (126) antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    26 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    95 ovary fGS/OSS    16 ovary OSC    26 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    27 Schneider line 2 Sg4    20 embryonic 1182-4H    55 embryonic GM2    24 embryonic Kc167    21 embryonic S1    38 embryonic S3    30 leg disc CME L1    24 wing disc CME-W2    61 wing disc ML-DmD8    33 wing disc ML-DmD9    72 wing disc ML-DmD16-c3    52 wing disc ML-DmD21    10 wing disc ML-DmD32    113 haltere disc ML-DmD17-c3    30 eye-antennal disc ML-DmD11    126 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    26 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    95 ovary fGS/OSS    16 ovary OSC    26 ovary OSS    17 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    27 Schneider line 2 Sg4    20 embryonic 1182-4H    55 embryonic GM2    24 embryonic Kc167    21 embryonic S1    38 embryonic S3    30 leg disc CME L1    24 wing disc CME-W2    61 wing disc ML-DmD8    33 wing disc ML-DmD9    72 wing disc ML-DmD16-c3    52 wing disc ML-DmD21    10 wing disc ML-DmD32    113 haltere disc ML-DmD17-c3    30 eye-antennal disc ML-DmD11    126 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    26 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    95 ovary fGS/OSS    16 ovary OSC    26 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  27 Schneider line 2 Sg4    20 embryonic 1182-4H  (55) embryonic GM2    24 embryonic Kc167    21 embryonic S1  (38) embryonic S3  30 leg disc CME L1    24 wing disc CME-W2  (61) wing disc ML-DmD8  (33) wing disc ML-DmD9  (72) wing disc ML-DmD16-c3  (52) wing disc ML-DmD21    10 wing disc ML-DmD32  (113) haltere disc ML-DmD17-c3  30 eye-antennal disc ML-DmD11  (126) antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1  26 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2  (95) ovary fGS/OSS    16 ovary OSC  26 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    27 Schneider line 2 Sg4    20 embryonic 1182-4H    55 embryonic GM2    24 embryonic Kc167    21 embryonic S1    38 embryonic S3    30 leg disc CME L1    24 wing disc CME-W2    61 wing disc ML-DmD8    33 wing disc ML-DmD9    72 wing disc ML-DmD16-c3    52 wing disc ML-DmD21    10 wing disc ML-DmD32  113 haltere disc ML-DmD17-c3    30 eye-antennal disc ML-DmD11  126 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    26 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    95 ovary fGS/OSS    16 ovary OSC    26 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    27 Schneider line 2 Sg4    20 embryonic 1182-4H    55 embryonic GM2    24 embryonic Kc167    21 embryonic S1    38 embryonic S3    30 leg disc CME L1    24 wing disc CME-W2    61 wing disc ML-DmD8    33 wing disc ML-DmD9    72 wing disc ML-DmD16-c3    52 wing disc ML-DmD21    10 wing disc ML-DmD32    113 haltere disc ML-DmD17-c3    30 eye-antennal disc ML-DmD11    126 antennal disc ML-DmD20-c5    19 mixed discs ML-DmD4-c1    26 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    24 tumorous blood cells mbn2    95 ovary fGS/OSS    16 ovary OSC    26 ovary OSS    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    21 cold shock, 4-day adult    15 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    71 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    113 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    67 Ethanol 2.5% 3 hrs, larvae L3    33 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    54 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    43 Paraquat 10 mM 48 hrs, 4-day adult    32 Rotenone 2 μg 12 hrs, larvae L3    19 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    21 cold shock, 4-day adult    15 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult  (33) Cadmium 100 mM 48 hrs, 4-day adult  (71) Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult  (113) Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult  (67) Ethanol 2.5% 3 hrs, larvae L3  (33) Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (54) Caffeine 25 mg/ml 48 hrs, 4-day adult  (27) Paraquat 5 mM 48 hrs, 4-day adult  (43) Paraquat 10 mM 48 hrs, 4-day adult  (32) Rotenone 2 μg 12 hrs, larvae L3    19 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    21 cold shock, 4-day adult    15 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    71 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult  (113) Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    67 Ethanol 2.5% 3 hrs, larvae L3    33 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    54 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    43 Paraquat 10 mM 48 hrs, 4-day adult    32 Rotenone 2 μg 12 hrs, larvae L3    19 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    21 cold shock, 4-day adult    15 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    71 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    113 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    67 Ethanol 2.5% 3 hrs, larvae L3    33 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    54 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    43 Paraquat 10 mM 48 hrs, 4-day adult    32 Rotenone 2 μg 12 hrs, larvae L3    19 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    21 cold shock, 4-day adult    15 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    71 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    113 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    67 Ethanol 2.5% 3 hrs, larvae L3    33 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    54 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    43 Paraquat 10 mM 48 hrs, 4-day adult    32 Rotenone 2 μg 12 hrs, larvae L3    19 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    21 cold shock, 4-day adult    15 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult  (33) Cadmium 100 mM 48 hrs, 4-day adult  (71) Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult  (113) Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult  (67) Ethanol 2.5% 3 hrs, larvae L3  (33) Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (54) Caffeine 25 mg/ml 48 hrs, 4-day adult  27 Paraquat 5 mM 48 hrs, 4-day adult  (43) Paraquat 10 mM 48 hrs, 4-day adult  32 Rotenone 2 μg 12 hrs, larvae L3    19 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    21 cold shock, 4-day adult    15 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    71 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult  113 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    67 Ethanol 2.5% 3 hrs, larvae L3    33 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    54 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    43 Paraquat 10 mM 48 hrs, 4-day adult    32 Rotenone 2 μg 12 hrs, larvae L3    19 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    21 cold shock, 4-day adult    15 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    13 Cadmium 50 mM 12 hrs, larvae L3    20 Cadmium 50 mM 48 hrs, 4-day adult    33 Cadmium 100 mM 48 hrs, 4-day adult    71 Copper 0.5 mM 12 hrs, larvae L3    15 Copper 15 mM 48 hrs, 4-day adult    113 Zinc 5 mM 12 hrs, larvae L3    16 Zinc 4.5 mM 48 hrs, 4-day adult    67 Ethanol 2.5% 3 hrs, larvae L3    33 Ethanol 5% 3 hrs, larvae L3    18 Ethanol 10% 3 hrs, larvae L3    16 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    54 Caffeine 25 mg/ml 48 hrs, 4-day adult    27 Paraquat 5 mM 48 hrs, 4-day adult    43 Paraquat 10 mM 48 hrs, 4-day adult    32 Rotenone 2 μg 12 hrs, larvae L3    19 Rotenone 8 μg 12 hrs, larvae L3    12 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_27 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001404 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • GH01085;CG9659-RC
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal egh7 egh9pp4 lethal | germline clone | maternal effect | recessive egh27 lethal | germline clone | neurogenic phenotype egh27 lethal | maternal effect | pupal stage egh27 lethal | pharate adult stage | recessive egh27 egh62d18 lethal | pupal stage | recessive egh1 egh2 egh3 egh5 egh6 egh7 egh8 egh9pp4 egh10 egh11 egh25 egh27 lethal | recessive egh1 egh2 egh3 egh4 egh5 egh6 egh7 egh8 egh9 egh9pp4 egh10 egh11 egh12 egh13 egh14 egh15 egh17 egh18 egh19 egh22 egh24 egh25 egh62d18 eghM15 eghM19 eghM36 eghM54 eghT4 partially lethal - majority die egh6 egh16 egh21 egh23 viable eghcm eghmedley viable, with Scer\GAL4pnr-MD237 eghGD3206 Sterility Allele female sterile egh3 egh7 egh9pp4 egh25 egh62d18 eghcm eghmedley female sterile | germline clone | recessive egh27 Other Phenotypes Allele behavior defective eghcm2 eghcm behavior defective (with egh7) eghcm behavior defective (with eghcm) egh7 courtship behavior defective | male eghEP804 eghEY03917 courtship behavior defective | male | heat sensitive, with Scer\GAL4ap-md544, Scer\GAL80ts.αTub84B eghGD3206 courtship behavior defective | male | heat sensitive, with Scer\GAL4elav-C155, Scer\GAL80ts.αTub84B eghGD3206 neuroanatomy defective egh3 egh7 egh9pp4 visible eghmedley wild-type egh+t7 eghhs.PG Phenotype manifest in Allele abdominal tergite 1 egh1 egh5 abdominal tergite 2 egh1 egh5 abdominal tergite 3 egh1 egh5 abdominal tergite 4 egh1 egh5 abdominal tergite 5 egh1 egh5 abdominal tergite 6 egh1 egh5 abdominal tergite 7 egh1 egh5 basal stalk egh25 basal stalk | germline clone egh27 egh3 egh62d18 egh7 egh9pp4 denticle belt egh25 dorsal appendage | germline clone egh25 egh27 egh3 egh62d18 egh7 egh9pp4 egg eghmedley egg | germline clone egh11 egg chamber | germline clone | maternal effect egh27 embryonic/larval midgut | embryonic stage egh27 embryonic/larval optic neuropil egh3 egh7 eye egh1 egh5 eghcm eghmedley female reproductive system egh11 first optic chiasm eghcm follicle cell egh25 eghmedley follicle cell | germline clone egh27 egh3 egh7 egh9pp4 germline cell egh8 eghcm lamina anlage egh7 lamina anlage glial cell egh7 lamina plexus egh3 egh7 egh9pp4 lobula egh7 lobula & neuron egh7 macrochaeta egh1 egh5 eghBG01635 nervous system | germline clone egh27 nurse cell egh25 eghcm nurse cell | germline clone egh27 egh3 egh62d18 egh7 egh9pp4 oocyte egh25 eghcm eghmedley oocyte | germline clone egh27 egh3 egh62d18 egh7 egh9pp4 oocyte | precursor eghcm ovary eghcm photoreceptor cell eghcm photoreceptor cell R1 & axon egh3 egh7 egh9pp4 photoreceptor cell R2 & axon egh3 egh7 egh9pp4 photoreceptor cell R3 & axon egh3 egh7 egh9pp4 photoreceptor cell R4 & axon egh3 egh7 egh9pp4 photoreceptor cell R5 & axon egh3 egh7 egh9pp4 photoreceptor cell R6 & axon egh3 egh7 egh9pp4 presumptive embryonic/larval nervous system | germline clone egh25 egh27 egh3 egh62d18 egh7 egh9pp4 procephalic segment egh25 ventral nerve cord (with egh7) eghcm ventral nerve cord (with eghcm) egh7 ventral nerve cord | somatic clone egh7 wing vein eghmedley
Classical Alleles ( 51 )
For All Classical Alleles Show
Allele of egh Class Mutagen Stocks Known lesion egh7 hypomorphic allele - genetic evidence X ray ethylenimine ethyl methanesulfonate 2 Yes eghd03687 P-element activity 1 -- eghEP804 P-element activity 1 Yes eghEY03917 1 -- eghNP5092 1 -- eghNP7190 1 -- eghUM-8329-3 1 -- egh10 X ray ethylenimine 0 -- egh11 ethylenimine 0 -- egh12 ethylenimine 0 -- egh13 ethyl methanesulfonate 0 -- egh14 ethyl methanesulfonate 0 -- egh15 ethyl methanesulfonate 0 -- egh16 ethyl methanesulfonate 0 -- egh17 ethyl methanesulfonate 0 -- egh18 methyl methanesulfonate 0 -- egh19 methyl methanesulfonate 0 -- egh1 N-methyl-N'-nitro-N-nitrosoguanidine 0 -- egh21 methyl methanesulfonate 0 -- egh22 methyl methanesulfonate 0 -- egh23 methyl methanesulfonate 0 -- egh24 methyl methanesulfonate 0 -- egh25 X ray 0 -- egh26 X ray 0 -- egh27 ethyl methanesulfonate 0 -- egh28 ethyl methanesulfonate 0 -- egh29 ethyl methanesulfonate 0 -- egh2 X ray 0 -- egh30 ethyl methanesulfonate 0 -- egh3 X ray ethyl methanesulfonate 0 Yes egh4 X ray ethylenimine 0 -- egh5 spontaneous 0 -- egh62d18 ethyl methanesulfonate 0 Yes egh6 X ray 0 -- egh8 X ray ethylenimine 0 -- egh9 ethylenimine 0 -- egh9pp4 ethyl methanesulfonate 0 Yes eghBG01635 P-element activity 0 Yes eghC502a 0 -- eghcm2 0 Yes eghcm hypomorphic allele - genetic evidence 0 Yes eghGG01685 0 -- eghM15 methyl methanesulfonate 0 -- eghM19 methyl methanesulfonate 0 -- eghM36 methyl methanesulfonate 0 -- eghM54 methyl methanesulfonate 0 -- eghmedley 0 -- eghNKu1 urethane 0 -- eghNKu2 urethane 0 -- eghNKx1 X ray 0 -- eghT4 methyl methanesulfonate 0 --
Alleles Carried on Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Allele of egh Class Mutagen Stocks Known lesion eghGD3206 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes eghJF03102 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes egh+t7 in vitro construct - genomic fragment 0 Yes egh+tP2 in vitro construct - genomic fragment 0 Yes eghhs.PG in vitro construct - regulatory fusion 0 Yes eghP1 in vitro construct - genomic fragment 0 Yes eghScer\UAS.cFa in vitro construct - regulatory fusion 0 Yes eghScer\UAS.cWa in vitro construct - regulatory fusion 0 Yes eghScer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes eght9 in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)7 (Nomura and Kurokawa, 1997) Df(1)63e4 (Williams et al., 1995, Goode et al., 1996) Df(1)64c4 (Judd et al., 1972, Thierry-Mieg, 1982) Df(1)HM3 (Kramers et al., 1983) Df(1)HM406 (Kramers et al., 1983) Df(1)K95 (Judd et al., 1972, Thierry-Mieg, 1982) Df(1)L126 (Nomura and Kurokawa, 1997) Df(1)NKx2 (Nomura and Kurokawa, 1997) Df(1)TEM1 (Lim and Snyder, 1974, Kramers et al., 1983, Kramers et al., 1991) Df(1)TEM7 (Lim and Snyder, 1974, Liu and Lim, 1975, Thierry-Mieg, 1982, Paradi et al., 1983, Kramers et al., 1983, Kramers et al., 1991) Df(1)TEM75 (Lim and Snyder, 1974) Df(1)TEM501 (Lim and Snyder, 1974, Kramers et al., 1983, Kramers et al., 1991) Df(1)w258-11 (Judd et al., 1972, Thierry-Mieg, 1982) Df(1)w258-42 (Judd et al., 1972, Thierry-Mieg, 1982) Df(1)w258-48 (Kramers et al., 1983, Kramers et al., 1991) Df(1)w-N71a (Judd et al., 1972) Df(1)w-rJ1 (Judd et al., 1972, Lim and Snyder, 1974, Liu and Lim, 1975, Thierry-Mieg, 1982, Paradi et al., 1983, Kramers et al., 1983, Kramers et al., 1991, Nomura and Kurokawa, 1997) Df(1)X12 (Judd et al., 1972, Thierry-Mieg, 1982) Df(1)z-deb54 (Goldberg et al., 1989) Df(1)z-deb62 (Goldberg et al., 1989) Df(1)z-deb65 (Goldberg et al., 1989) Df(1)z-deb72 (Goldberg et al., 1989) Df(1)z-deb81 (Goldberg et al., 1989) Df(1)z-deb85 (Goldberg et al., 1989) Df(1)z-deb311 (Goldberg et al., 1989) Df(1)z-deb511 (Goldberg et al., 1989) Df(1)z-EM41 (Montgomery et al., 1991) Df(1)z-EM42 (Montgomery et al., 1991) Df(1)z-EM43 (Montgomery et al., 1991) Df(1)z-EM44 (Montgomery et al., 1991) Df(1)z-EM45 (Montgomery et al., 1991) Df(1)z-EM46 (Montgomery et al., 1991)
Duplicated in	Dp(1;2;Y)w+ (Judd et al., 1972, Kramers et al., 1983, Kramers et al., 1991) Dp(1;3)DC045 (Popodi et al., 2010-, Venken et al., 2010) Dp(1;3)w+67k (Judd et al., 1972) Dp(1;Y)y267g19.1 (Lefevre, 1981)
Not disrupted in	Df(1)62d18 (Judd et al., 1972) Df(1)62g18 (Judd et al., 1972, Thierry-Mieg, 1982) Df(1)64f1 (Judd et al., 1972, Thierry-Mieg, 1982, Lin and Wolfner, 1989) Df(1)64j4 (Judd et al., 1972, Thierry-Mieg, 1982, Lin and Wolfner, 1989) Df(1)65j26 (Judd et al., 1972, Thierry-Mieg, 1982) Df(1)202 (Nomura and Kurokawa, 1997) Df(1)304 (Nomura and Kurokawa, 1997) Df(1)N-8 (Lin and Wolfner, 1989, Kramers et al., 1991) Df(1)N-54l9 (Kramers et al., 1991) Df(1)N-264-105 (Kramers et al., 1991) Df(1)Pgd-kz (Kramers et al., 1991) Df(1)Sp2F-3A (Schalet, 1986) Df(1)TEM6 (Lim and Snyder, 1974) Df(1)TEM202 (Liu and Lim, 1975, Paradi et al., 1983, Kramers et al., 1983, Kramers et al., 1991) Df(1)TEM304 (Lim and Snyder, 1974, Liu and Lim, 1975, Paradi et al., 1983, Kramers et al., 1983, Kramers et al., 1991) Df(1)w55j (Lin and Wolfner, 1989) Df(1)w67k30 (Kramers et al., 1991) Df(1)w258-45 (Judd et al., 1972, Thierry-Mieg, 1982, Lin and Wolfner, 1989) Df(1)w-rJ2 (Judd et al., 1972) Df(1)z-deb3 (Goldberg et al., 1989) Df(1)z-deb42 (Goldberg et al., 1989) Df(1)z-deb59 (Goldberg et al., 1989) Df(1)z-deb87 (Goldberg et al., 1989) Df(1)z-deb92 (Goldberg et al., 1989) Df(1)z-deb910 (Goldberg et al., 1989)
Not duplicated in	Dp(1;2)51b (Kramers et al., 1991) Dp(1;2)w+70h (Judd et al., 1972) Dp(1;3)N264-58 (Judd et al., 1972) Dp(1;3)wm49a (Judd et al., 1972) Dp(1;3)wvco (Schalet, 1986) Dp(1;4)wm65g (Judd et al., 1972)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD3206} NA P{TRiP.JF03102} NA P{UAS-egh.HA} NA P{UAS-egh.W} NA reporter construct P{egh-lacZ.S} No heat-shock construct P{HSegh} NA characterization construct P{18XS} NA P{egh.P2} NA P{eghP1} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}eghEP804 NA P{EPgy2}eghEY03917 NA P{Mae-UAS.6.11}eghGG01685 NA P{XP}eghd03687 NA miscellaneous insertions P{GT1}eghBG01635 NA P{RS3}eghUM-8329-3 NA insertion of enhancer trap binary system P{GawB}eghNP5092 No P{GawB}eghNP7190 No P{GawB}wdsC502a No
Gene Ontology: Function, Process & Cellular Component ( 19 unique terms )
Terms Based on Experimental Evidence ( 17 terms )
Molecular Function
CV term Evidence References
beta-1,4-mannosyltransferase activity inferred from direct assay (Wandall et al., 2003)
Biological Process
CV term Evidence References
axon guidance inferred from mutant phenotype (Soller et al., 2006) border follicle cell migration inferred from mutant phenotype (Goode et al., 1996) cell fate commitment inferred from mutant phenotype (Rubsam et al., 1998) dsRNA transport inferred from mutant phenotype (Saleh et al., 2006) germarium-derived egg chamber formation inferred from mutant phenotype (Goode et al., 1996) germ cell development inferred from mutant phenotype (Rubsam et al., 1998) maintenance of polarity of follicular epithelium inferred from mutant phenotype (Goode et al., 1996) male courtship behavior inferred from mutant phenotype (Ellis and Carney, 2011) morphogenesis of follicular epithelium inferred from mutant phenotype (Goode et al., 1996) negative regulation of female receptivity, post-mating inferred from mutant phenotype (Soller et al., 2006) oocyte localization involved in germarium-derived egg chamber formation inferred from mutant phenotype (Rubsam et al., 1998) oocyte microtubule cytoskeleton organization inferred from mutant phenotype (Rubsam et al., 1998) optic lobe placode formation inferred from mutant phenotype (Fan et al., 2005) ovarian follicle cell-cell adhesion inferred from mutant phenotype (Goode et al., 1996) ovarian follicle cell development inferred from mutant phenotype (Goode et al., 1996, Rubsam et al., 1998) regulation of oviposition inferred from mutant phenotype (Soller et al., 2006)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
oogenesis traceable author statement (Deng and Lin, 2001) ovarian follicle cell development traceable author statement (Dobens and Raftery, 2000)
Cellular Component
CV term Evidence References
integral to plasma membrane non-traceable author statement (Swiss-Prot Project Members, 1998.2.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions egh allele Gene References egh7 h (Bianchi-Frias et al., 2004) unspecified brn (Fan et al., 2005) Dl (Simmerl et al., 1995) Egfr (Simmerl et al., 1995)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 57772 DroID - A comprehensive database of gene and protein interactions. • FBgn0001404 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31239
Orthologs
OrthoDB Orthologs (33) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6WSWWB Dipteran inclusive ortholog search EOG6933S9 Insect inclusive ortholog search EOG6280WZ Arthropod inclusive ortholog search EOG62RBPP Metazoa inclusive ortholog search EOG6BGNPB
Orthologs in Drosophila Species (EOG6WSWWB)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\egh     Drosophila sechellia   Dsec\GM19231 Y   Drosophila erecta   Dere\GG12939 Y   Drosophila yakuba   Dyak\GE16264 Y   Drosophila ananassae   Dana\GF22218 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA21947 Y   Drosophila persimilis   Dper\GL13057 Y   Drosophila persimilis   Dper\GL13058     Drosophila persimilis   Dper\GL13059     Drosophila persimilis   Dper\GL10059     Drosophila willistoni   Dwil\GK20024 Y   Drosophila virilis   Dvir\GJ16504 Y   Drosophila mojavensis   Dmoj\GI15300 Y   Drosophila grimshawi   Dgri\GH17906 Y
Orthologs in non-Drosophila Dipterans (EOG6933S9)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL004688   Anopheles gambiae Malaria mosquito  Agam\AGAP000868   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ019153
Orthologs in non-Dipteran Insects (EOG6280WZ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG009130   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16247   Atta cephalotes Leafcutter ant  Acep\ACEP16696   Camponotus floridanus Florida carpenter ant  Cflo\CFLO19549   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14186   Linepithema humile Argentine ant  Lhum\LH10044   Pogonomyrmex barbatus Red harvester ant  Pbar\PB24086   Solenopsis invicta Red fire ant  Sinv\SINV17339   Acyrthosiphon pisum Pea aphid  Apim\ACYPI003798   Bombyx mori Silkmoth  Bmor\BGIBMGA001169   Pediculus humanus Human body louse  Phum\PHUM588760   Tribolium castaneum Red flour beetle  Tcas\GLEAN_08154
Orthologs in non-Insect Arthropods (EOG62RBPP)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\RPB2   Daphnia pulex Water flea  Dpux\DUOX2   Ixodes scapularis Deer tick  Isca\ISCW017328
Orthologs in non-Arthropod Metazoa (EOG6BGNPB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\bre-3
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD16612 Drosophila sechellia Dsec\GM19231 Drosophila erecta Dere\GG12939 Drosophila yakuba Dyak\GE16264 Drosophila ananassae Dana\GF22218 Drosophila pseudoobscura pseudoobscura Dpse\GA21947 Drosophila persimilis Dper\GL13057 Drosophila willistoni Dwil\GK20024 Drosophila virilis Dvir\GJ16504 Drosophila mojavensis Dmoj\GI15300 Drosophila grimshawi Dgri\GH17906
Stocks & Reagents
Stocks Listed in FlyBase ( 12 )
Bloomington	10084 P{EP}eghEP804 w1118 3902 egh7/FM7a/Dp(1;2;Y)w+ 28687 y1 v1; P{TRiP.JF03102}attP2 15689 y1 P{EPgy2}eghEY03917 w67c23
Harvard	- P{XP}eghd03687
Kyoto	107261 egh7/FM7a/Dp(1;2;Y)w+ 124483 P{RS3}eghUM-8329-3 w1118 114134 P{GawB}eghNP7190 w* / FM7c 104847 y* P{GawB}eghNP5092 w* / FM7c
VDRC	v10137 w1118 P{GD3206}v10137 v45160 w1118; P{GD3206}v45160 v45161 w1118; P{GD3206}v45161
Genomic Clones ( 1 )
	BACR09H13 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 240 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH01085 RE12962 RE23171 RE47491
Other clones	FI18161
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH06738 LP02011 RE06279 RE14024 RE21590 RE29689 RE37764 RH44991 RH68158
Other clones	10183 32924 119747 159995 558142 562181 CK01.72D.E4 CK01.74D.E3 Dmel_neb_009038_0076_2664 Dmel_neb_014269_0940_2885 EK057650 EK110119 EK251131 EN09006 EN13851 FGH103F10 RP003000837 RP003001697 RP003003199 RP003003996 RP003005892 RP003011337 RP003014610 RP003014886 RP003022553 RP003029879 RP003038006 RP003039966 RP003040773 RP003041181 RP003041389 RP003042576 RP003042664 RP003045838 RP003046945 RP003046961 RP003051063 RP003055042 RP003058860 RP003060510 RP003062716 RP003069493 RP003076134 RP003090788 RP003091932 RP003092934 RP003097071 RP003097330 RP003111297 RP003113616 RP003119032 RP003120598 RP003121534 RP003124662 RP003128859 RP003131382 RP003134951 RP003135207 RP003145965 RP003146451 RP003149105 RP003149973 RP003154799 RP003158920 RP003162470 RP003164855 RP003169853 RP003172957 RP003176828 RP003179921 RP003182219 RP003184971 RP003193955 RP003197816 RP003198063 RP003198878 RP003198905 RP003200619 RP003204486 RP003211078 RP003213757 RP003216190 RP003216319 RP003218676 RP003218713 RP003219540 RP003221996 RP003224500 RP003226778 RP003227112 RP003228522 RP003231437 RP003233422 RP003240680 RP003248247 RP003248695 RP003248929 RP003256069 RP003260484 RP003263946 RP003265749 RP003266152 RP003266601 RP003268906 RP003269961 RP003275278 RP003277244 RP003282223 RP003286074 RP003287867 RP003290424 RP003293396 RP003293553 RP003299622 RP003301093 RP003301918 RP003304429 RP003305752 RP003308525 RP003312119 RP003314157 RP003315294 RP003316580 RP003319398 RP003319429 RP003320049 RP003321446 RP003322771 RP003326569 RP003331617 RP003335704 RP003336877 RP003343033 RP003343655 RP003352119 RP003352623 RP003356005 RP003359687 RP003365201 RP003365935 RP003373617 RP003381035 RP003384828 RP003385582 RP003397866 RP003399077 RP003405406 RP003411288 RP003411589 RP003411688 RP003412457 RP003415823 RP003416661 RP003424613 RP003425242 RP003427566 RP003428961 RP003432182 RP003433941 RP003434749 RP003441073 RP003442888 RP003447737 RP003448165 RP003448363 RP003449821 RP003450329 RP003460796 RP003461145 RP003464595 RP003468016 RP003484205 RP003495529 RP003497492 RP003511620 RP003517574 RP003518638 RP003521555 RP003521936 RP003523809 RP003528484 RP003529474 RP003530190 RP003530604 RP003530680 RP003531528 RP003532732 RP003534918 RP003537457 RP003541415 RP003542031 RP003542418 RP003546097 RP003546107 RP003548849 RP003554017 RP003555415 RP003556343 RP003564798 RP003567909 RP003571259 RP003571727 RP003572965 RP003575249 RP003575253 RP003578078 RP003578527 RP003578984 RP003590624 RP003593923 RP003593929 RP003601643 RP003609735 RP003613701 RP003631821 RP003640814 RP003643939 RP003645924 RP003647219 RP003649669 RP003660985 RP003661531 RP003663134 RP003664019 RP003669917 RP003673188
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0001404 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31239
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: egh CG9659 (Nusskern, 1999.11)
Source for database merge of
Additional comments
Other Comments
	egh is important for germ cell differentiation, for the integrity of the cortical actin cytoskeleton of the germ cells and for the establishment of a correct anteroposterior axis of the egg chamber. (Rubsam et al., 1998) Phenotypic analysis proposes that brn and egh, originating from the germline, collaborate with N on the apical surface of follicle cells to mediate germline-follicle cell adhesion. Wild type function of egh and brn is required for the formation of the follicular epithelium and maintenance of the apical-basal polarity, to inhibit follicle cell division, induction of dorsal follicle cell fates (but not specification of polar/stalk cell fates) and for concerted border cell-main body epithelium migration. (Goode et al., 1996) egh encodes a transmembrane protein. (Schafer, 1995.9.19) The egh and Egfr gene products cooperate in the same pathway during oogenesis and eye development. egh acts upstream of Egfr in the germ line. egh and Dl interact in the development of the embryonic nervous system. (Simmerl et al., 1995)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080313 NM_166946 RefSeq (Proteins) • NP_525052 NP_726818 DDBJ / EMBL / GenBank • AAB49734 AAB49735 AAF43419 AAF45792 AAL28143 AAN09081 AF233288 AI062041 AL138972 AW940094 AY060595 CAB72293 CZ473504 U15602 U21218 Entrez Gene - A searchable database of RefSeq genes. • 31239 UniProtKB/Swiss-Prot • O01346 UniProtKB/TrEMBL • A4V3W0 Q95ST6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Beta-1,4-mannosyltransferase Bre-3/Egh (IPR027389)
Linkouts
	BioGRID - A database of protein and genetic interactions • 57772 DroID - A comprehensive database of gene and protein interactions. • FBgn0001404 DRSC - Results from RNAi screens. • FBgn0001404 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001404 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • GH01085;CG9659-RC FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0001404 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31239 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/egghead.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31239 modMine - Data generated by the modENCODE project. • FBgn0001404
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG9659 (Norga et al., 2003, Benos, 2000.12.13, Saleh et al., 2006, Perkins et al., 2009, Ellis and Carney, 2011) EG:BACR25B3.8 (Benos, 2000.2.6, Benos et al., 2001, Benos, 2000.12.13) egh (Protzer et al., 2009, McDermott and Kliman, 2008, Chen et al., 2007, Pizette et al., 2009, Saleh et al., 2009, Demakov et al., 2004, Popodi et al., 2010-, Hamel et al., 2010, Ellis and Carney, 2011, Venken et al., 2010) l(1)3Ae   l(1)zw4 (Rubsam et al., 1997, Williams et al., 1995, Williams et al., 1992, Endow and Hatsumi, 1991, Lin and Wolfner, 1989, Paradi et al., 1983, Garcia-Bellido and Robbins, 1983, Lim and Snyder, 1974, Shannon et al., 1972, ) zw4 (Melnick, 1995.2.17, Williams et al., 1997, Goode et al., 1996, Montgomery et al., 1991, Goldberg et al., 1989, Schalet, 1986, Lefevre and Watkins, 1986, Robbins, 1983, Thierry-Mieg, 1982, Lefevre, 1981, Judd et al., 1972) zw-4 (Nomura and Kurokawa, 1997, Kramers et al., 1991, Kramers et al., 1983, Liu and Lim, 1975) ZW-4 (Paradi et al., 1983)
Name Synonym	egghead (Soller et al., 2006, Moran and Kyriacou, 2009, Chen et al., 2007, Saleh et al., 2006, Pizette et al., 2009, Saleh et al., 2009, Demakov et al., 2004, Beckstead et al., 2007, Ellis and Carney, 2011) zeste-white 4 (Melnick, 1994.10.6, Melnick, 1995.2.17)
Secondary FlyBase IDs
References ( 86 )
Generate a list of	All references relating to this gene ( 86 )
List References by type	Research paper  ( 48 ) Supplementary material  ( 4 ) Review  ( 7 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 8 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 4 ) Curated genome annotation  ( 2 ) Protein sequence record  ( 1 ) Book  ( 1 )
Recent research papers ( 2 )
	Dahlgaard et al., 2012, Proc. Natl. Acad. Sci. U.S.A. 109(18): 6987--6992 Neurofibromatosis-like phenotype in Drosophila caused by lack of glucosylceramide extension. [FBrf0218176] Ellis and Carney, 2011, Genetics 187(1): 157--169 Socially-Responsive Gene Expression in Male Drosophila melanogaster Is Influenced by the Sex of the Interacting Partner. [FBrf0212780] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...