zw4, l(1)zw4, zw-4, EG:BACR25B3.8 , zeste-white 4
Gene model reviewed during 5.50
3.7 (northern blot)
457 (aa); 52 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\egh using the Feature Mapper tool.
All four egh transcripts are expressed at all developmental stages, with the 3.5kb transcript expressed at higher levels in adult females that have stored eggs. Maternally-supplied egh transcript is uniformly distributed in early embryos. In later embryos, egh transcripts become enriched in the developing CNS. Larval expression is also observed in the CNS, as well as in additional tissues including the imaginal discs. In adults, egh transcript is enriched in the head.
The in-situ localization of egh transcript is consistent with the proposed role of egh in epithelial morphogenesis during oogenesis. egh transcript is first detected during oogenesis in germ cells at the junction of germarium regions 2a and 2b. From stage S4 to S9, the egh transcript differentially accumulates in the oocyte. At stage S10, egh transcript expression declines in oocytes but increases in nurse cells. Subsequently, the content of nurse cells is transferred to oocytes. Northern analysis shows that the egh transcript is present in 0-2 hour embryos.
GBrowse - Visual display of RNA-Seq signalsView Dmel\egh in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: egh CG9659
egh is important for germ cell differentiation, for the integrity of the cortical actin cytoskeleton of the germ cells and for the establishment of a correct anteroposterior axis of the egg chamber.
Phenotypic analysis proposes that brn and egh, originating from the germline, collaborate with N on the apical surface of follicle cells to mediate germline-follicle cell adhesion. Wild type function of egh and brn is required for the formation of the follicular epithelium and maintenance of the apical-basal polarity, to inhibit follicle cell division, induction of dorsal follicle cell fates (but not specification of polar/stalk cell fates) and for concerted border cell-main body epithelium migration.