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Gene Dmel\Hlc

General Information
Symbol	Dmel\Hlc	Species	D. melanogaster
Name	Helicase	Annotation symbol	CG1666
Feature type	protein_coding_gene	FlyBase ID	FBgn0001565
Gene Model Status	Current	Stock availability	13 publicly available
Also Known As	A112, l(1)A112, 11P1
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	20A1-20A1	Sequence location	X:21,256,545..21,258,973 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Helicase is referred to in FlyBase by the symbol Dmel\Hlc (CG1666, FBgn0001565). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ATP-dependent RNA helicase activity. There is experimental evidence that it is involved in the biological process: neurogenesis. 22 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; central nervous system; peripheral nervous system; mesothoracic tergum. It has one annotated transcript and one annotated polypeptide. Protein features are: DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Helicase, C-terminal; Helicase, superfamily 1/2, ATP-binding domain; RNA helicase, DEAD-box type, Q motif. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult eye, adult crop, adult hindgut, adult heart, larval trachea, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, larval/adult midgut, larval hindgut, larval/adult Malpighian tubules, larval/adult fat body, larval/adult salivary gland, adult female reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1638310_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Hlc. Gene sequence location is X:21256545..21258973.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	l(1)19Ff Mutant embryos have no obvious defects of central nervous system (CNS), peripheral nervous system (PNS), or cuticle. Germ line clones lethal (Perrimon, Smouse, and Miklos, 1989, Genetics 121: 313-31).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 20A1-20A1   Limits computationally determined from genome sequence between P{EP}CG1702EP1525 and P{EP}EP1465&P{EP}CG1486EP1192
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)	slgA (Hayward et al., 1993) bb (Schalet, 1972)
Right of (cM)	mal (Schalet, 1972)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Hlc for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.46
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Hlc-RA FBtr0077221  NM_078710   2116   560
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Hlc-PA   FBpp0076917   62.9   560   9.67     NP_523434   AAF50818
Additional Polypeptide Data & Comments
Reported size (kDa)	560 (aa) (Maleszka et al., 1998)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Helicase, C-terminal (IPR001650) DNA/RNA helicase, DEAD/DEAH box type, N-terminal (IPR011545) Helicase, superfamily 1/2, ATP-binding domain (IPR014001) RNA helicase, DEAD-box type, Q motif (IPR014014) P-loop containing nucleoside triphosphate hydrolase (IPR027417)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202710   AA246999   AA264607   AA390741   AA391572   AA392555   AA392643   AA392832   AA439068   AA439795   AA695210   AA695735   AA735968   AA816343   AA820180   AA820559   AA951975   AA951976   AA978450   AA978871   AA979556   AE014298 AAF50818   AF017777 AAC28406   AI061675   AI114400   AI297989   AI297992   AI406261   AI455664   AI457090   AI511955   AI512377   AI514618   AI515032   AI515127   AI515785   AI516329   AI517876   AI518855   AI518858   AI520165   AI520241   AI520551   AI542611   AI543982   AI546411   AY070624 AAL48095   AY113641 AAM29646   BG635753   BI161677   BI161678   BI164875   BI165137   BI165179   BI170222   BI213840   BI233084   BI234241   BI237920   BI242012   BI364048   BI369050   BI369824   BI483884   BI484402   BI566933   BI566983   BI567818   BI567857   BI570059   BI570084   BI575212   BI578554   BI578773   BI578869   BI578914   BI579450   BI580181   BI583603   BI586461   BI589797   BI592907   BI593170   BI604868   BI605952   BI606230   BI606943   BI607049   BI607384   BI607414   BI613466   BI615426   BI624900   BI629523   BI635879   BI636750   BI639305   BI641445   BP545232   BP545233   CK657701   CK660322   CK662171   CO179613   CO188539   CO192716   CO270625   CO286597   CO288122   CO295054   CO304289   CO310962   CO337824   CO344089   CO344357   CZ486560   CZ486561   EC051628   EC052121   EC052643   EC056412   EC069521   EC082088   EC082438   EC195323   EC196025   EC201522   EC205801   EC225168   EC237155   EC240269   EC255091   EC258546   EL881123   EL881124   EL881225   EL881226   EL881339   EL881340   EL883517   EV584292   EV588036
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VRI0 Q8MYS0
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Maleszka et al., 1998) larval stage   imaginal disc   (Maleszka et al., 1998) embryonic/larval fat body   (Maleszka et al., 1998) embryonic/larval brain   (Maleszka et al., 1998) embryonic/larval salivary gland   (Maleszka et al., 1998) pupal stage | late   adult brain   (Maleszka et al., 1998) brain   (Maleszka et al., 1998) adult stage   adult brain   (Maleszka et al., 1998) adult stage & oogenesis   ovary   (Maleszka et al., 1998)
Additional Descriptive Data
	Hlc transcripts are detected in embryos, larvae, pupae, and adults on northern blots. They are observed in ovaries, salivary gland, larval fat body, imaginal discs, and in larval, late pupal and adult brain by RT-PCR. (Maleszka et al., 1998)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult organs/tissues expressed at moderate or high levels. Expression at high levels in the following post-embryonic organs or tissues: adult eye, adult crop, adult hindgut, adult heart, larval trachea, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, larval/adult midgut, larval hindgut, larval/adult Malpighian tubules, larval/adult fat body, larval/adult salivary gland, adult female reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    277.7 Larval Midgut    185.8 Larval Hindgut    350.2 Larval Malpighian Tubules    458.4 Larval Fat Body    167.9 Larval Salivary Gland    222.6 Larval Trachea    526.175 Larval Carcass    308.675 Adult Head    378.9 Adult Eye    785.675 Adult Brain    384.3 Adult Thoracic-Abdominal Ganglion    395.4 Adult Crop    501.3 Adult Midgut    215.3 Adult Hindgut    545.2 Adult Malpighian Tubules    359.4 Adult Fat Body    384.9 Adult Salivary Gland    451.2 Adult Heart    627.425 Adult VirginFemale Spermatheca    415.4 Adult InseminatedFemale Spermatheca    410.3 Adult Ovary    481.9 Adult Testis    31.1 Adult Male Accessory Gland    606.3 Adult Carcass    364.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    277.7 Larval Midgut    185.8 Larval Hindgut    350.2 Larval Malpighian Tubules    458.4 Larval Fat Body    167.9 Larval Salivary Gland    222.6 Larval Trachea  526.175 Larval Carcass    308.675 Adult Head    378.9 Adult Eye  (785.675) Adult Brain    384.3 Adult Thoracic-Abdominal Ganglion    395.4 Adult Crop  501.3 Adult Midgut    215.3 Adult Hindgut  (545.2) Adult Malpighian Tubules    359.4 Adult Fat Body    384.9 Adult Salivary Gland    451.2 Adult Heart  (627.425) Adult VirginFemale Spermatheca    415.4 Adult InseminatedFemale Spermatheca    410.3 Adult Ovary    481.9 Adult Testis    31.1 Adult Male Accessory Gland  (606.3) Adult Carcass    364.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    277.7 Larval Midgut    185.8 Larval Hindgut    350.2 Larval Malpighian Tubules    458.4 Larval Fat Body    167.9 Larval Salivary Gland    222.6 Larval Trachea    526.175 Larval Carcass    308.675 Adult Head    378.9 Adult Eye    785.675 Adult Brain    384.3 Adult Thoracic-Abdominal Ganglion    395.4 Adult Crop    501.3 Adult Midgut    215.3 Adult Hindgut    545.2 Adult Malpighian Tubules    359.4 Adult Fat Body    384.9 Adult Salivary Gland    451.2 Adult Heart    627.425 Adult VirginFemale Spermatheca    415.4 Adult InseminatedFemale Spermatheca    410.3 Adult Ovary    481.9 Adult Testis    31.1 Adult Male Accessory Gland    606.3 Adult Carcass    364.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    277.7 Larval Midgut    185.8 Larval Hindgut    350.2 Larval Malpighian Tubules    458.4 Larval Fat Body    167.9 Larval Salivary Gland    222.6 Larval Trachea    526.175 Larval Carcass    308.675 Adult Head    378.9 Adult Eye    785.675 Adult Brain    384.3 Adult Thoracic-Abdominal Ganglion    395.4 Adult Crop    501.3 Adult Midgut    215.3 Adult Hindgut    545.2 Adult Malpighian Tubules    359.4 Adult Fat Body    384.9 Adult Salivary Gland    451.2 Adult Heart    627.425 Adult VirginFemale Spermatheca    415.4 Adult InseminatedFemale Spermatheca    410.3 Adult Ovary    481.9 Adult Testis    31.1 Adult Male Accessory Gland    606.3 Adult Carcass    364.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    277.7 Larval Midgut    185.8 Larval Hindgut    350.2 Larval Malpighian Tubules    458.4 Larval Fat Body    167.9 Larval Salivary Gland    222.6 Larval Trachea    526.175 Larval Carcass    308.675 Adult Head    378.9 Adult Eye    785.675 Adult Brain    384.3 Adult Thoracic-Abdominal Ganglion    395.4 Adult Crop    501.3 Adult Midgut    215.3 Adult Hindgut    545.2 Adult Malpighian Tubules    359.4 Adult Fat Body    384.9 Adult Salivary Gland    451.2 Adult Heart    627.425 Adult VirginFemale Spermatheca    415.4 Adult InseminatedFemale Spermatheca    410.3 Adult Ovary    481.9 Adult Testis    31.1 Adult Male Accessory Gland    606.3 Adult Carcass    364.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    277.7 Larval Midgut    185.8 Larval Hindgut    350.2 Larval Malpighian Tubules    458.4 Larval Fat Body    167.9 Larval Salivary Gland    222.6 Larval Trachea  526.175 Larval Carcass    308.675 Adult Head    378.9 Adult Eye  785.675 Adult Brain    384.3 Adult Thoracic-Abdominal Ganglion    395.4 Adult Crop  501.3 Adult Midgut    215.3 Adult Hindgut  545.2 Adult Malpighian Tubules    359.4 Adult Fat Body    384.9 Adult Salivary Gland    451.2 Adult Heart  627.425 Adult VirginFemale Spermatheca    415.4 Adult InseminatedFemale Spermatheca    410.3 Adult Ovary    481.9 Adult Testis    31.1 Adult Male Accessory Gland  606.3 Adult Carcass    364.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    277.7 Larval Midgut    185.8 Larval Hindgut    350.2 Larval Malpighian Tubules    458.4 Larval Fat Body    167.9 Larval Salivary Gland    222.6 Larval Trachea    526.175 Larval Carcass    308.675 Adult Head    378.9 Adult Eye    785.675 Adult Brain    384.3 Adult Thoracic-Abdominal Ganglion    395.4 Adult Crop    501.3 Adult Midgut    215.3 Adult Hindgut    545.2 Adult Malpighian Tubules    359.4 Adult Fat Body    384.9 Adult Salivary Gland    451.2 Adult Heart    627.425 Adult VirginFemale Spermatheca    415.4 Adult InseminatedFemale Spermatheca    410.3 Adult Ovary    481.9 Adult Testis    31.1 Adult Male Accessory Gland    606.3 Adult Carcass    364.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    277.7 Larval Midgut    185.8 Larval Hindgut    350.2 Larval Malpighian Tubules    458.4 Larval Fat Body    167.9 Larval Salivary Gland    222.6 Larval Trachea    526.175 Larval Carcass    308.675 Adult Head    378.9 Adult Eye    785.675 Adult Brain    384.3 Adult Thoracic-Abdominal Ganglion    395.4 Adult Crop    501.3 Adult Midgut    215.3 Adult Hindgut    545.2 Adult Malpighian Tubules    359.4 Adult Fat Body    384.9 Adult Salivary Gland    451.2 Adult Heart    627.425 Adult VirginFemale Spermatheca    415.4 Adult InseminatedFemale Spermatheca    410.3 Adult Ovary    481.9 Adult Testis    31.1 Adult Male Accessory Gland    606.3 Adult Carcass    364.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    378.9   NA  Eye    785.675   NA  Brain    384.3   277.7  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    395.4   NA  Crop    501.3   185.8  Midgut    215.3   350.2  Hindgut    545.2   458.4  Malpighian Tubules    359.4   167.9  Fat Body    384.9   222.6  Salivary Gland    451.2   NA  Heart    627.425   526.175  Trachea    NA   NA  VirginFemale Spermatheca    415.4   NA  InseminatedFemale Spermatheca    410.3   NA  Ovary    481.9   NA  Testis    31.1   NA  Male Accessory Gland    606.3   308.675  Carcass    364.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    13 central nervous system, pupae P8    12 head, virgin 1-day female    18 head, virgin 4-day female    22 head, virgin 20-day female    27 head, mated 1-day female    22 head, mated 4-day female    20 head, mated 20-day female    18 head, mated 1-day male    28 head, mated 4-day male    22 head, mated 20-day male    25 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    14 digestive system, 4-day adult    13 digestive system, 20-day adult    16 fat body, larvae L3 wandering    8 fat body, white prepupae    10 fat body, pupae P8    31 carcass, larvae L3 wandering    28 carcass, 1-day adult    14 carcass, 4-day adult    15 carcass, 20-day adult    20 ovary, virgin 4-day female    64 ovary, mated 4-day female    53 testis, mated 4-day male    6 accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    13 central nervous system, pupae P8    12 head, virgin 1-day female    18 head, virgin 4-day female    22 head, virgin 20-day female  (27) head, mated 1-day female    22 head, mated 4-day female    20 head, mated 20-day female    18 head, mated 1-day male  (28) head, mated 4-day male    22 head, mated 20-day male    25 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    14 digestive system, 4-day adult    13 digestive system, 20-day adult    16 fat body, larvae L3 wandering    8 fat body, white prepupae    10 fat body, pupae P8  (31) carcass, larvae L3 wandering  (28) carcass, 1-day adult    14 carcass, 4-day adult    15 carcass, 20-day adult    20 ovary, virgin 4-day female  (64) ovary, mated 4-day female  (53) testis, mated 4-day male    6 accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    13 central nervous system, pupae P8    12 head, virgin 1-day female    18 head, virgin 4-day female    22 head, virgin 20-day female    27 head, mated 1-day female    22 head, mated 4-day female    20 head, mated 20-day female    18 head, mated 1-day male    28 head, mated 4-day male    22 head, mated 20-day male    25 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    14 digestive system, 4-day adult    13 digestive system, 20-day adult    16 fat body, larvae L3 wandering    8 fat body, white prepupae    10 fat body, pupae P8    31 carcass, larvae L3 wandering    28 carcass, 1-day adult    14 carcass, 4-day adult    15 carcass, 20-day adult    20 ovary, virgin 4-day female    64 ovary, mated 4-day female    53 testis, mated 4-day male    6 accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    13 central nervous system, pupae P8    12 head, virgin 1-day female    18 head, virgin 4-day female    22 head, virgin 20-day female    27 head, mated 1-day female    22 head, mated 4-day female    20 head, mated 20-day female    18 head, mated 1-day male    28 head, mated 4-day male    22 head, mated 20-day male    25 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    14 digestive system, 4-day adult    13 digestive system, 20-day adult    16 fat body, larvae L3 wandering    8 fat body, white prepupae    10 fat body, pupae P8    31 carcass, larvae L3 wandering    28 carcass, 1-day adult    14 carcass, 4-day adult    15 carcass, 20-day adult    20 ovary, virgin 4-day female    64 ovary, mated 4-day female    53 testis, mated 4-day male    6 accessory gland, mated 4-day male    20 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    13 central nervous system, pupae P8    12 head, virgin 1-day female    18 head, virgin 4-day female    22 head, virgin 20-day female    27 head, mated 1-day female    22 head, mated 4-day female    20 head, mated 20-day female    18 head, mated 1-day male    28 head, mated 4-day male    22 head, mated 20-day male    25 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    14 digestive system, 4-day adult    13 digestive system, 20-day adult    16 fat body, larvae L3 wandering    8 fat body, white prepupae    10 fat body, pupae P8    31 carcass, larvae L3 wandering    28 carcass, 1-day adult    14 carcass, 4-day adult    15 carcass, 20-day adult    20 ovary, virgin 4-day female    64 ovary, mated 4-day female    53 testis, mated 4-day male    6 accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    13 central nervous system, pupae P8    12 head, virgin 1-day female    18 head, virgin 4-day female    22 head, virgin 20-day female  27 head, mated 1-day female    22 head, mated 4-day female    20 head, mated 20-day female    18 head, mated 1-day male  28 head, mated 4-day male    22 head, mated 20-day male    25 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    14 digestive system, 4-day adult    13 digestive system, 20-day adult    16 fat body, larvae L3 wandering    8 fat body, white prepupae    10 fat body, pupae P8  31 carcass, larvae L3 wandering  28 carcass, 1-day adult    14 carcass, 4-day adult    15 carcass, 20-day adult    20 ovary, virgin 4-day female  (64) ovary, mated 4-day female  (53) testis, mated 4-day male    6 accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    13 central nervous system, pupae P8    12 head, virgin 1-day female    18 head, virgin 4-day female    22 head, virgin 20-day female    27 head, mated 1-day female    22 head, mated 4-day female    20 head, mated 20-day female    18 head, mated 1-day male    28 head, mated 4-day male    22 head, mated 20-day male    25 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    14 digestive system, 4-day adult    13 digestive system, 20-day adult    16 fat body, larvae L3 wandering    8 fat body, white prepupae    10 fat body, pupae P8    31 carcass, larvae L3 wandering    28 carcass, 1-day adult    14 carcass, 4-day adult    15 carcass, 20-day adult    20 ovary, virgin 4-day female    64 ovary, mated 4-day female    53 testis, mated 4-day male    6 accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    19 central nervous system, larvae L3    13 central nervous system, pupae P8    12 head, virgin 1-day female    18 head, virgin 4-day female    22 head, virgin 20-day female    27 head, mated 1-day female    22 head, mated 4-day female    20 head, mated 20-day female    18 head, mated 1-day male    28 head, mated 4-day male    22 head, mated 20-day male    25 salivary gland, larvae L3 wandering    6 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    23 digestive system, 1-day adult    14 digestive system, 4-day adult    13 digestive system, 20-day adult    16 fat body, larvae L3 wandering    8 fat body, white prepupae    10 fat body, pupae P8    31 carcass, larvae L3 wandering    28 carcass, 1-day adult    14 carcass, 4-day adult    15 carcass, 20-day adult    20 ovary, virgin 4-day female    64 ovary, mated 4-day female    53 testis, mated 4-day male    6 accessory gland, mated 4-day male    20 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    101 embryo 02-04hr    131 embryo 04-06hr    102 embryo 06-08hr    100 embryo 08-10hr    110 embryo 10-12hr    77 embryo 12-14hr    60 embryo 14-16hr    60 embryo 16-18hr    54 embryo 18-20hr    54 embryo 20-22hr    85 embryo 22-24hr    84 larva L1    54 larva L2    26 larva L3 12hr old    24 larva L3 puffstage 1-2    30 larva L3 puffstage 3-6    37 larva L3 puffstage 7-9    41 white prepupae new    34 white prepupae 12hr    33 white prepupae 24hr    33 pupae 2d postWPP    24 pupae 3d postWPP    19 pupae 4d postWPP    22 adult male 01day    31 adult male 05day    34 adult male 30day    25 adult female 01day    58 adult female 05day    70 adult female 30day    69 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (101) embryo 02-04hr  (131) embryo 04-06hr  (102) embryo 06-08hr  (100) embryo 08-10hr  (110) embryo 10-12hr  (77) embryo 12-14hr  (60) embryo 14-16hr  (60) embryo 16-18hr  (54) embryo 18-20hr  (54) embryo 20-22hr  (85) embryo 22-24hr  (84) larva L1  (54) larva L2  26 larva L3 12hr old    24 larva L3 puffstage 1-2  (30) larva L3 puffstage 3-6  (37) larva L3 puffstage 7-9  (41) white prepupae new  (34) white prepupae 12hr  (33) white prepupae 24hr  (33) pupae 2d postWPP    24 pupae 3d postWPP    19 pupae 4d postWPP    22 adult male 01day  (31) adult male 05day  (34) adult male 30day    25 adult female 01day  (58) adult female 05day  (70) adult female 30day  (69) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  101 embryo 02-04hr  (131) embryo 04-06hr  102 embryo 06-08hr    100 embryo 08-10hr  (110) embryo 10-12hr    77 embryo 12-14hr    60 embryo 14-16hr    60 embryo 16-18hr    54 embryo 18-20hr    54 embryo 20-22hr    85 embryo 22-24hr    84 larva L1    54 larva L2    26 larva L3 12hr old    24 larva L3 puffstage 1-2    30 larva L3 puffstage 3-6    37 larva L3 puffstage 7-9    41 white prepupae new    34 white prepupae 12hr    33 white prepupae 24hr    33 pupae 2d postWPP    24 pupae 3d postWPP    19 pupae 4d postWPP    22 adult male 01day    31 adult male 05day    34 adult male 30day    25 adult female 01day    58 adult female 05day    70 adult female 30day    69 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    101 embryo 02-04hr    131 embryo 04-06hr    102 embryo 06-08hr    100 embryo 08-10hr    110 embryo 10-12hr    77 embryo 12-14hr    60 embryo 14-16hr    60 embryo 16-18hr    54 embryo 18-20hr    54 embryo 20-22hr    85 embryo 22-24hr    84 larva L1    54 larva L2    26 larva L3 12hr old    24 larva L3 puffstage 1-2    30 larva L3 puffstage 3-6    37 larva L3 puffstage 7-9    41 white prepupae new    34 white prepupae 12hr    33 white prepupae 24hr    33 pupae 2d postWPP    24 pupae 3d postWPP    19 pupae 4d postWPP    22 adult male 01day    31 adult male 05day    34 adult male 30day    25 adult female 01day    58 adult female 05day    70 adult female 30day    69 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    101 embryo 02-04hr    131 embryo 04-06hr    102 embryo 06-08hr    100 embryo 08-10hr    110 embryo 10-12hr    77 embryo 12-14hr    60 embryo 14-16hr    60 embryo 16-18hr    54 embryo 18-20hr    54 embryo 20-22hr    85 embryo 22-24hr    84 larva L1    54 larva L2    26 larva L3 12hr old    24 larva L3 puffstage 1-2    30 larva L3 puffstage 3-6    37 larva L3 puffstage 7-9    41 white prepupae new    34 white prepupae 12hr    33 white prepupae 24hr    33 pupae 2d postWPP    24 pupae 3d postWPP    19 pupae 4d postWPP    22 adult male 01day    31 adult male 05day    34 adult male 30day    25 adult female 01day    58 adult female 05day    70 adult female 30day    69 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (101) embryo 02-04hr  (131) embryo 04-06hr  (102) embryo 06-08hr  (100) embryo 08-10hr  (110) embryo 10-12hr  (77) embryo 12-14hr  (60) embryo 14-16hr  (60) embryo 16-18hr  (54) embryo 18-20hr  (54) embryo 20-22hr  (85) embryo 22-24hr  (84) larva L1  (54) larva L2  26 larva L3 12hr old    24 larva L3 puffstage 1-2  30 larva L3 puffstage 3-6  (37) larva L3 puffstage 7-9  (41) white prepupae new  (34) white prepupae 12hr  (33) white prepupae 24hr  (33) pupae 2d postWPP    24 pupae 3d postWPP    19 pupae 4d postWPP    22 adult male 01day  31 adult male 05day  (34) adult male 30day    25 adult female 01day  (58) adult female 05day  (70) adult female 30day  (69) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  101 embryo 02-04hr  131 embryo 04-06hr  102 embryo 06-08hr    100 embryo 08-10hr  110 embryo 10-12hr    77 embryo 12-14hr    60 embryo 14-16hr    60 embryo 16-18hr    54 embryo 18-20hr    54 embryo 20-22hr    85 embryo 22-24hr    84 larva L1    54 larva L2    26 larva L3 12hr old    24 larva L3 puffstage 1-2    30 larva L3 puffstage 3-6    37 larva L3 puffstage 7-9    41 white prepupae new    34 white prepupae 12hr    33 white prepupae 24hr    33 pupae 2d postWPP    24 pupae 3d postWPP    19 pupae 4d postWPP    22 adult male 01day    31 adult male 05day    34 adult male 30day    25 adult female 01day    58 adult female 05day    70 adult female 30day    69 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    101 embryo 02-04hr    131 embryo 04-06hr    102 embryo 06-08hr    100 embryo 08-10hr    110 embryo 10-12hr    77 embryo 12-14hr    60 embryo 14-16hr    60 embryo 16-18hr    54 embryo 18-20hr    54 embryo 20-22hr    85 embryo 22-24hr    84 larva L1    54 larva L2    26 larva L3 12hr old    24 larva L3 puffstage 1-2    30 larva L3 puffstage 3-6    37 larva L3 puffstage 7-9    41 white prepupae new    34 white prepupae 12hr    33 white prepupae 24hr    33 pupae 2d postWPP    24 pupae 3d postWPP    19 pupae 4d postWPP    22 adult male 01day    31 adult male 05day    34 adult male 30day    25 adult female 01day    58 adult female 05day    70 adult female 30day    69 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    95 Schneider line 2 Sg4    24 embryonic 1182-4H    56 embryonic GM2    62 embryonic Kc167    99 embryonic S1    48 embryonic S3    23 leg disc CME L1    22 wing disc CME-W2    17 wing disc ML-DmD8    31 wing disc ML-DmD9    33 wing disc ML-DmD16-c3    28 wing disc ML-DmD21    36 wing disc ML-DmD32    26 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    25 mixed discs ML-DmD4-c1    27 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    30 tumorous blood cells mbn2    30 ovary fGS/OSS    47 ovary OSC    24 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (95) Schneider line 2 Sg4    24 embryonic 1182-4H  (56) embryonic GM2  (62) embryonic Kc167  (99) embryonic S1  (48) embryonic S3    23 leg disc CME L1    22 wing disc CME-W2    17 wing disc ML-DmD8  (31) wing disc ML-DmD9  (33) wing disc ML-DmD16-c3  (28) wing disc ML-DmD21  (36) wing disc ML-DmD32  26 haltere disc ML-DmD17-c3  (33) eye-antennal disc ML-DmD11  (28) antennal disc ML-DmD20-c5    25 mixed discs ML-DmD4-c1  (27) CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2  (30) tumorous blood cells mbn2  (30) ovary fGS/OSS  (47) ovary OSC    24 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    95 Schneider line 2 Sg4    24 embryonic 1182-4H    56 embryonic GM2    62 embryonic Kc167    99 embryonic S1    48 embryonic S3    23 leg disc CME L1    22 wing disc CME-W2    17 wing disc ML-DmD8    31 wing disc ML-DmD9    33 wing disc ML-DmD16-c3    28 wing disc ML-DmD21    36 wing disc ML-DmD32    26 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    25 mixed discs ML-DmD4-c1    27 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    30 tumorous blood cells mbn2    30 ovary fGS/OSS    47 ovary OSC    24 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    95 Schneider line 2 Sg4    24 embryonic 1182-4H    56 embryonic GM2    62 embryonic Kc167    99 embryonic S1    48 embryonic S3    23 leg disc CME L1    22 wing disc CME-W2    17 wing disc ML-DmD8    31 wing disc ML-DmD9    33 wing disc ML-DmD16-c3    28 wing disc ML-DmD21    36 wing disc ML-DmD32    26 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    25 mixed discs ML-DmD4-c1    27 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    30 tumorous blood cells mbn2    30 ovary fGS/OSS    47 ovary OSC    24 ovary OSS    19 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    95 Schneider line 2 Sg4    24 embryonic 1182-4H    56 embryonic GM2    62 embryonic Kc167    99 embryonic S1    48 embryonic S3    23 leg disc CME L1    22 wing disc CME-W2    17 wing disc ML-DmD8    31 wing disc ML-DmD9    33 wing disc ML-DmD16-c3    28 wing disc ML-DmD21    36 wing disc ML-DmD32    26 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    25 mixed discs ML-DmD4-c1    27 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    30 tumorous blood cells mbn2    30 ovary fGS/OSS    47 ovary OSC    24 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (95) Schneider line 2 Sg4    24 embryonic 1182-4H  (56) embryonic GM2  (62) embryonic Kc167  (99) embryonic S1  (48) embryonic S3    23 leg disc CME L1    22 wing disc CME-W2    17 wing disc ML-DmD8  31 wing disc ML-DmD9  (33) wing disc ML-DmD16-c3  28 wing disc ML-DmD21  (36) wing disc ML-DmD32  26 haltere disc ML-DmD17-c3  (33) eye-antennal disc ML-DmD11  28 antennal disc ML-DmD20-c5    25 mixed discs ML-DmD4-c1  27 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2  30 tumorous blood cells mbn2  30 ovary fGS/OSS  (47) ovary OSC    24 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    95 Schneider line 2 Sg4    24 embryonic 1182-4H    56 embryonic GM2    62 embryonic Kc167    99 embryonic S1    48 embryonic S3    23 leg disc CME L1    22 wing disc CME-W2    17 wing disc ML-DmD8    31 wing disc ML-DmD9    33 wing disc ML-DmD16-c3    28 wing disc ML-DmD21    36 wing disc ML-DmD32    26 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    25 mixed discs ML-DmD4-c1    27 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    30 tumorous blood cells mbn2    30 ovary fGS/OSS    47 ovary OSC    24 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    95 Schneider line 2 Sg4    24 embryonic 1182-4H    56 embryonic GM2    62 embryonic Kc167    99 embryonic S1    48 embryonic S3    23 leg disc CME L1    22 wing disc CME-W2    17 wing disc ML-DmD8    31 wing disc ML-DmD9    33 wing disc ML-DmD16-c3    28 wing disc ML-DmD21    36 wing disc ML-DmD32    26 haltere disc ML-DmD17-c3    33 eye-antennal disc ML-DmD11    28 antennal disc ML-DmD20-c5    25 mixed discs ML-DmD4-c1    27 CNS ML-DmBG1-c1    25 CNS ML-DmBG2-c2    30 tumorous blood cells mbn2    30 ovary fGS/OSS    47 ovary OSC    24 ovary OSS    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    11 heat shock, 4-day adult    26 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    30 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    63 Ethanol 5% 3 hrs, larvae L3    21 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    29 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    46 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    48 Paraquat 10 mM 48 hrs, 4-day adult    59 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    11 heat shock, 4-day adult  26 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult  (30) Cadmium 100 mM 48 hrs, 4-day adult  (44) Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3  (63) Ethanol 5% 3 hrs, larvae L3    21 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3  (29) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (46) Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult  (48) Paraquat 10 mM 48 hrs, 4-day adult  (59) Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    11 heat shock, 4-day adult    26 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    30 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    63 Ethanol 5% 3 hrs, larvae L3    21 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    29 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    46 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    48 Paraquat 10 mM 48 hrs, 4-day adult    59 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    11 heat shock, 4-day adult    26 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    30 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    63 Ethanol 5% 3 hrs, larvae L3    21 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    29 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    46 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    48 Paraquat 10 mM 48 hrs, 4-day adult    59 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    11 heat shock, 4-day adult    26 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    30 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    63 Ethanol 5% 3 hrs, larvae L3    21 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    29 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    46 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    48 Paraquat 10 mM 48 hrs, 4-day adult    59 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    11 heat shock, 4-day adult  26 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult  30 Cadmium 100 mM 48 hrs, 4-day adult  (44) Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3  (63) Ethanol 5% 3 hrs, larvae L3    21 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3  29 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (46) Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult  (48) Paraquat 10 mM 48 hrs, 4-day adult  (59) Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    11 heat shock, 4-day adult    26 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    30 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    63 Ethanol 5% 3 hrs, larvae L3    21 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    29 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    46 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    48 Paraquat 10 mM 48 hrs, 4-day adult    59 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    14 cold shock, 4-day adult    11 heat shock, 4-day adult    26 Cadmium 50 mM 6 hrs, larvae L3    11 Cadmium 50 mM 12 hrs, larvae L3    22 Cadmium 50 mM 48 hrs, 4-day adult    30 Cadmium 100 mM 48 hrs, 4-day adult    44 Copper 0.5 mM 12 hrs, larvae L3    7 Copper 15 mM 48 hrs, 4-day adult    23 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    20 Ethanol 2.5% 3 hrs, larvae L3    63 Ethanol 5% 3 hrs, larvae L3    21 Ethanol 10% 3 hrs, larvae L3    14 Caffeine 1.5 mg/ml 4 hrs, larvae L3    29 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    46 Caffeine 25 mg/ml 48 hrs, 4-day adult    13 Paraquat 5 mM 48 hrs, 4-day adult    48 Paraquat 10 mM 48 hrs, 4-day adult    59 Rotenone 2 μg 12 hrs, larvae L3    17 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_08 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001565 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1666-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele cell lethal | germline clone Hlc17-62 Hlc19Ff-2 Hlc19Ff-6 Hlc19Ff-7 lethal Hlc19Ff-6 HlcGD9183 lethal | larval stage | recessive Hlc19Ff-2 lethal | recessive Hlc17-62 Hlc19Ff-2 Hlc19Ff-5 Hlc19Ff-6 Hlc19Ff-7 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 HlcGD9183 viable Hlcf06483 viable, with Scer\GAL4pnr-MD237 HlcGD16441 Sterility Allele fertile Hlcf06483 Other Phenotypes Allele neuroanatomy defective | larval stage HlcGD9183 visible, with Scer\GAL4pnr-MD237 HlcGD9183 wild-type Hlc+t4.8 Hlc+t11.6 Phenotype manifest in Allele central nervous system Hlc17-62 Hlc19Ff-6 Hlc19Ff-7 embryonic/larval neuroblast | larval stage HlcGD9183 ganglion mother cell | larval stage HlcGD9183 mesothoracic tergum, with Scer\GAL4pnr-MD237 HlcGD9183 peripheral nervous system Hlc17-62 Hlc19Ff-6 Hlc19Ff-7 trichogen cell, with Scer\GAL4pnr-MD237 HlcGD9183
Classical Alleles ( 13 )
For All Classical Alleles Show
Allele of Hlc Class Mutagen Stocks Known lesion Hlcf06483 piggyBac transposase 2 -- Hlc17-62 1 -- Hlc19Ff-1 X ray 1 -- Hlc19Ff-2 X ray 1 -- Hlc19Ff-6 X ray 1 -- Hlc19Ff-7 spontaneous 1 -- Hlcf03964 piggyBac transposase 1 -- Hlc19Ff-3 ethyl methanesulfonate 0 -- Hlc19Ff-4 ethyl methanesulfonate 0 -- Hlc19Ff-5 ethyl methanesulfonate 0 -- HlcHM44 0 Yes HlcJA117 0 Yes HlcJC77 0 Yes
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Hlc Class Mutagen Stocks Known lesion HlcGD9183 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes HlcGD16441 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes HlcHMS01424 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes HlcJF02921 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Hlc+t11.6 in vitro construct - genomic fragment 0 Yes Hlc+t4.8 in vitro construct - genomic fragment 0 Yes HlcNIG.1666R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes HlctMa in vitro construct - genomic fragment 0 Yes HlctMb in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)2/19B (Perrimon et al., 1989, Miklos and de Couet, 1990, Maleszka et al., 1996) Df(1)14-11 (Munoz, 2003.12.10) Df(1)16-1-88 (Munoz, 2004.1.5) Df(1)16-3-22 (Miklos et al., 1987) Df(1)16-3-95 (Munoz, 2004.1.5) Df(1)16-3-129 (Munoz, 2004.1.5) Df(1)16-3-139 (Munoz, 2004.1.5) Df(1)16-3-160 (Munoz, 2004.1.5) Df(1)17-59 (Schalet and Lefevre, 1973) Df(1)17-241 (Munoz, 2003.12.10) Df(1)17-244 (Munoz, 2004.1.5) Df(1)17-257 (Miklos et al., 1987, Perrimon et al., 1989, Miklos and de Couet, 1990, Russell et al., 1992, Maleszka et al., 1996) Df(1)17-322 (Munoz, 2004.1.5) Df(1)17-351 (Miklos et al., 1987, Perrimon et al., 1989, Miklos and de Couet, 1990) Df(1)17-412 (Munoz, 2004.1.5) Df(1)17-489 (Miklos et al., 1987, Perrimon et al., 1989) Df(1)18-36 (Munoz, 2004.1.5) Df(1)19-2 (Munoz, 2004.1.5) Df(1)19-18 (Munoz, 2003.12.10, Munoz, 2004.1.5) Df(1)26B (Perrimon et al., 1989) Df(1)A53 (Perrimon et al., 1989) Df(1)A58 (Lifschytz and Falk, 1968) Df(1)B12 (Lifschytz and Falk, 1968, Lifschytz and Falk, 1969, Lifschytz and Yakobovitz, 1978, Prud'homme et al., 1995) Df(1)B82 (Lifschytz and Falk, 1969) Df(1)C74 (Perrimon et al., 1989, Miklos and de Couet, 1990) Df(1)D5 (Eeken et al., 1985) Df(1)D43L1 (Rahman and Lindsley, 1981, Eeken et al., 1985, Perrimon et al., 1989, Kramers et al., 1991) Df(1)DCB1-35b (Perrimon et al., 1989, Prud'homme et al., 1995) Df(1)GA33 (Perrimon et al., 1989) Df(1)GA37 (Perrimon et al., 1989) Df(1)GA40 (Perrimon et al., 1989) Df(1)GA104 (Miklos et al., 1987, Perrimon et al., 1989, Miklos and de Couet, 1990, Maleszka et al., 1996) Df(1)GE263 (Miklos et al., 1987, Perrimon et al., 1989, Miklos and de Couet, 1990) Df(1)HM44 (Miklos et al., 1986, Miklos et al., 1987, Perrimon et al., 1989, Miklos and de Couet, 1990, Miklos et al., 1997) Df(1)JA117 (Miklos et al., 1987, Perrimon et al., 1989, Miklos and de Couet, 1990, Miklos et al., 1997) Df(1)JC77 (Miklos et al., 1987, Perrimon et al., 1989, Miklos and de Couet, 1990, Miklos et al., 1997) Df(1)LB6 (Perrimon et al., 1989, Prud'homme et al., 1995) Df(1)LB7 (Perrimon et al., 1989) Df(1)LB23 (Perrimon et al., 1989) Df(1)mal3 (Rahman and Lindsley, 1981, Kramers et al., 1991) Df(1)mal6 (Kramers et al., 1991) Df(1)mal12 (Rahman and Lindsley, 1980, Rahman and Lindsley, 1981) Df(1)n17-8 (Munoz, 2004.1.5) Df(1)N77 (Perrimon et al., 1989) Df(1)Q38 (Lifschytz and Falk, 1969) Df(1)Q219 (Lifschytz and Falk, 1969) Df(1)Q408 (Lifschytz and Falk, 1969) Df(1)Q539 (Lifschytz and Falk, 1969, Schalet and Lefevre, 1973, Miklos et al., 1987, Perrimon et al., 1989, Miklos and de Couet, 1990, Prud'homme et al., 1995, Miklos et al., 1997) Df(1)R1 (Rahman and Lindsley, 1981) Df(1)R4 (Rahman and Lindsley, 1981) Df(1)R5 (Rahman and Lindsley, 1981) Df(1)R9 (Rahman and Lindsley, 1981) Df(1)R-9-1 (Lifschytz and Falk, 1969) Df(1)R-10-5 (Lifschytz and Falk, 1969) Df(1)R11 (Rahman and Lindsley, 1981) Df(1)R34 (Rahman and Lindsley, 1981) Df(1)R39 (Rahman and Lindsley, 1981) Df(1)S54 (Miklos et al., 1987, Perrimon et al., 1989, Miklos and de Couet, 1990) Df(1)su(f)7085 (Lifschytz and Yakobovitz, 1978) Df(1)su(f)9122 (Lifschytz and Yakobovitz, 1978) Df(1)wl-2 (Lifschytz and Falk, 1969) Df(1)yl-1 (Lifschytz and Falk, 1969)
Not disrupted in	Df(1)16-2-13 (Miklos et al., 1987, Prud'homme et al., 1995) Df(1)16-3-35 (Eeken et al., 1985, Miklos et al., 1987, Perrimon et al., 1989, Kramers et al., 1991) Df(1)16-3-53 (Munoz, 2004.1.5) Df(1)16-129 (Eeken et al., 1985, Miklos et al., 1987, Perrimon et al., 1989, Miklos and de Couet, 1990, Maleszka et al., 1996) Df(1)16-185 (Rahman and Lindsley, 1981) Df(1)17-87 (Rahman and Lindsley, 1980, Rahman and Lindsley, 1981) Df(1)17-137 (Schalet and Lefevre, 1973, Rahman and Lindsley, 1981) Df(1)17-148 (Rahman and Lindsley, 1981, Prud'homme et al., 1995) Df(1)17-228 (Munoz, 2004.1.5) Df(1)17-369 (Munoz, 2004.1.5) Df(1)17-408 (Rahman and Lindsley, 1981) Df(1)17-456 (Munoz, 2004.1.5) Df(1)18-80 (Munoz, 2004.1.5, Schalet and Lefevre, 1973) Df(1)A19 (Lifschytz and Falk, 1968, Lifschytz and Falk, 1969) Df(1)A33 (Lifschytz and Falk, 1968, Lifschytz and Falk, 1969) Df(1)A58 (Lifschytz and Falk, 1969) Df(1)A118 (Lifschytz and Falk, 1968, Lifschytz and Falk, 1969, Lifschytz and Yakobovitz, 1978, Eeken et al., 1985, Miklos et al., 1987, Perrimon et al., 1989, Kramers et al., 1991) Df(1)A122 (Lifschytz and Falk, 1968, Lifschytz and Falk, 1969) Df(1)A129 (Lifschytz and Falk, 1968) Df(1)A161 (Lifschytz and Falk, 1968) Df(1)A200 (Lifschytz and Falk, 1968) Df(1)A209 (Lifschytz and Falk, 1968, Lifschytz and Falk, 1969, Rahman and Lindsley, 1980, Rahman and Lindsley, 1981) Df(1)A211 (Lifschytz and Falk, 1968) Df(1)B18 (Lifschytz and Falk, 1968) Df(1)B47 (Lifschytz and Falk, 1968) Df(1)B56 (Lifschytz and Falk, 1968, Lifschytz and Falk, 1969) Df(1)B57 (Lifschytz and Falk, 1968, Lifschytz and Falk, 1969, Lifschytz and Yakobovitz, 1978, Miklos et al., 1987, Perrimon et al., 1989, Miklos and de Couet, 1990) Df(1)B82 (Lifschytz and Falk, 1968) Df(1)B85 (Lifschytz and Falk, 1968) Df(1)B99 (Lifschytz and Falk, 1968) Df(1)B111 (Lifschytz and Falk, 1968, Lifschytz and Falk, 1969) Df(1)B155 (Lifschytz and Falk, 1968, Lifschytz and Falk, 1969) Df(1)B179 (Lifschytz and Falk, 1968) Df(1)B182 (Lifschytz and Falk, 1968) Df(1)B199 (Lifschytz and Falk, 1968) Df(1)B214 (Lifschytz and Falk, 1968, Lifschytz and Falk, 1969) Df(1)B225 (Lifschytz and Falk, 1968) Df(1)B240 (Lifschytz and Falk, 1968) Df(1)B255 (Lifschytz and Falk, 1968) Df(1)B264 (Lifschytz and Falk, 1968, Lifschytz and Falk, 1969) Df(1)DCB1-35c (Miklos et al., 1987, Prud'homme et al., 1995) Df(1)EA113 (Miklos et al., 1987) Df(1)GA22 (Miklos et al., 1987) Df(1)GA42 (Rahman and Lindsley, 1980, Rahman and Lindsley, 1981) Df(1)GA90 (Rahman and Lindsley, 1980, Rahman and Lindsley, 1981) Df(1)GA131 (Miklos et al., 1987) Df(1)HC279 (Perrimon et al., 1989) Df(1)HF359 (Miklos et al., 1987) Df(1)JA21 (Miklos et al., 1987) Df(1)JC4 (Miklos et al., 1987, Miklos and de Couet, 1990) Df(1)K5 (Rahman and Lindsley, 1981) Df(1)M31 (Lifschytz and Yakobovitz, 1978) Df(1)M158 (Lifschytz and Yakobovitz, 1978) Df(1)M171 (Lifschytz and Yakobovitz, 1978) Df(1)M176 (Lifschytz and Yakobovitz, 1978) Df(1)mal8 (Kramers et al., 1991) Df(1)mal10 (Perrimon et al., 1989) Df(1)mal17 (Perrimon et al., 1989) Df(1)Q539 (Kramers et al., 1991) Df(1)R2 (Rahman and Lindsley, 1981) Df(1)R3 (Rahman and Lindsley, 1981) Df(1)R6 (Rahman and Lindsley, 1981) Df(1)R7 (Rahman and Lindsley, 1981, Prud'homme et al., 1995) Df(1)R8 (Rahman and Lindsley, 1981) Df(1)R8A (Rahman and Lindsley, 1981) Df(1)R10 (Rahman and Lindsley, 1981) Df(1)R12 (Rahman and Lindsley, 1981) Df(1)R13 (Rahman and Lindsley, 1981) Df(1)R14 (Rahman and Lindsley, 1981) Df(1)R15 (Rahman and Lindsley, 1981) Df(1)R16 (Rahman and Lindsley, 1981) Df(1)R17 (Rahman and Lindsley, 1981) Df(1)R18 (Rahman and Lindsley, 1981) Df(1)R19 (Rahman and Lindsley, 1981) Df(1)R20 (Rahman and Lindsley, 1981, Prud'homme et al., 1995) Df(1)R21 (Rahman and Lindsley, 1981, Prud'homme et al., 1995) Df(1)R22 (Rahman and Lindsley, 1981) Df(1)R23 (Rahman and Lindsley, 1981) Df(1)R24 (Rahman and Lindsley, 1981) Df(1)R25 (Rahman and Lindsley, 1980, Rahman and Lindsley, 1981) Df(1)R26 (Rahman and Lindsley, 1981) Df(1)R27 (Rahman and Lindsley, 1981) Df(1)R28 (Rahman and Lindsley, 1981) Df(1)R29 (Rahman and Lindsley, 1981) Df(1)R30 (Rahman and Lindsley, 1981) Df(1)R31 (Rahman and Lindsley, 1981) Df(1)R32 (Rahman and Lindsley, 1981) Df(1)R33 (Rahman and Lindsley, 1981) Df(1)R35 (Rahman and Lindsley, 1981) Df(1)R36 (Rahman and Lindsley, 1981) Df(1)R37 (Rahman and Lindsley, 1981) Df(1)R38 (Rahman and Lindsley, 1981) Df(1)R40 (Rahman and Lindsley, 1981) Df(1)R41 (Rahman and Lindsley, 1981) Df(1)R42 (Rahman and Lindsley, 1981) Df(1)R43 (Rahman and Lindsley, 1981) Df(1)R44 (Rahman and Lindsley, 1980, Rahman and Lindsley, 1981, Prud'homme et al., 1995) Df(1)R45 (Rahman and Lindsley, 1981) Df(1)R46 (Rahman and Lindsley, 1981, Prud'homme et al., 1995) Df(1)R47 (Rahman and Lindsley, 1981) Df(1)R48 (Rahman and Lindsley, 1981) Df(1)run1112 (Perrimon et al., 1989) Df(1)Sp20A-F (Schalet, 1986) Df(1)su(f)4B (Kramers et al., 1991) Df(1)su(f)724 (Lifschytz and Yakobovitz, 1978, Prud'homme et al., 1995) Df(1)su(f)733 (Lifschytz and Yakobovitz, 1978) Df(1)su(f)754 (Lifschytz and Yakobovitz, 1978) Df(1)su(f)795 (Lifschytz and Yakobovitz, 1978) Df(1)su(f)7009 (Lifschytz and Yakobovitz, 1978) Df(1)T2-14A (Miklos et al., 1987, Perrimon et al., 1989) Df(1)X-1 (Lifschytz and Falk, 1968, Lifschytz and Falk, 1969, Rahman and Lindsley, 1980, Rahman and Lindsley, 1981) Df(1)y-X5 (Rahman and Lindsley, 1981) Df(1)y-X15 (Rahman and Lindsley, 1980, Rahman and Lindsley, 1981, Kramers et al., 1991) Dp(1;Y)y+mal126 (Lifschytz and Yakobovitz, 1978)
Duplicated in	Dp(1;f)mini2 (Perrimon et al., 1989) Dp(1;f)mini7 (Prud'homme et al., 1995) Dp(1;f)mini77 (Perrimon et al., 1989, Miklos and de Couet, 1990) Dp(1;f)mini-ring (Perrimon et al., 1989) Dp(1;Y)59k9-4 (Eeken et al., 1985) Dp(1;Y)B101 (Perrimon et al., 1989) Dp(1;Y)mal+ (Lifschytz and Falk, 1968, Rahman and Lindsley, 1981) Dp(1;Y)y+mal102 (Perrimon et al., 1989, Prud'homme et al., 1995) Dp(1;Y)y+mal106 (Miklos and de Couet, 1990, Prud'homme et al., 1995) Dp(1;Y)y+mal171 (Perrimon et al., 1989) Dp(1;Y)y+mal+ (Lefevre, 1981, Eeken et al., 1985, Prud'homme et al., 1995)
Not duplicated in	Dp(1;f)3 (Rahman and Lindsley, 1981) Dp(1;Y)BS (Kramers et al., 1991, Prud'homme et al., 1995) Dp(1;Y)BSYy+ (Rahman and Lindsley, 1981) Dp(1;Y)y267g19.1 (Eeken et al., 1985) Dp(1;Y)y+mal118 (Prud'homme et al., 1995) Dp(1;Y)y+mal126 (Schalet and Lefevre, 1973, Rahman and Lindsley, 1981, Miklos and de Couet, 1990) Dp(1;Y)y+malN152 (Prud'homme et al., 1995)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9183} NA P{GD16441} NA P{NIG.1666R} NA P{TRiP.HMS01424} NA P{TRiP.JF02921} NA characterization construct P{19F.A} NA P{19F.B} NA P{19F.C} NA P{slgA+GL2} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{WH}Hlcf03964 NA PBac{WH}Hlcf06483 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
neurogenesis inferred from mutant phenotype (Neumüller et al., 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR001650, InterPro:IPR011545 (FlyBase Curators et al., 2004-) ATP-dependent RNA helicase activity inferred from sequence or structural similarity with Saccharomyces DBP9 (FlyBase, 1992-, Lasko, 2000) nucleic acid binding inferred from electronic annotation with InterPro:IPR001650, InterPro:IPR011545 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Hlc - CG10496 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hlc - CG17601 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hlc - CG1785 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hlc - CG31637 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hlc - Csp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hlc - Eap anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hlc - Ect3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hlc - Kr-h1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hlc - Obp49a anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hlc - Ran anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hlc - Sbp2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Hlc - mTerf5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Hlc allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0001565 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33118
Orthologs
OrthoDB Orthologs (41) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6VT6GX Dipteran inclusive ortholog search EOG6B2T5K Insect inclusive ortholog search EOG6HDRPN Arthropod inclusive ortholog search EOG698SFX Metazoa inclusive ortholog search EOG6M9DK1
Orthologs in Drosophila Species (EOG6VT6GX)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Hlc     Drosophila simulans   Dsim\GD15498 Y   Drosophila sechellia   Dsec\GM22625 Y   Drosophila erecta   Dere\GG17541 Y   Drosophila yakuba   Dyak\GE15300 Y   Drosophila ananassae   Dana\GF21359 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA14086 Y   Drosophila persimilis   Dper\GL15985 Y   Drosophila willistoni   Dwil\GK24230 Y   Drosophila virilis   Dvir\GJ15568 Y   Drosophila mojavensis   Dmoj\GI21708 Y   Drosophila grimshawi   Dgri\GH24281 Y
Orthologs in non-Drosophila Dipterans (EOG6B2T5K)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL004445   Anopheles gambiae Malaria mosquito  Agam\AGAP011147   Anopheles gambiae Malaria mosquito  Agam\AGAP011145   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ008189
Orthologs in non-Dipteran Insects (EOG6HDRPN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB55090   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG020441   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH26301   Atta cephalotes Leafcutter ant  Acep\ACEP17268   Camponotus floridanus Florida carpenter ant  Cflo\CFLO18156   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20628   Linepithema humile Argentine ant  Lhum\LH13501   Pogonomyrmex barbatus Red harvester ant  Pbar\PB22032   Solenopsis invicta Red fire ant  Sinv\SINV25755   Solenopsis invicta Red fire ant  Sinv\SINV25756   Acyrthosiphon pisum Pea aphid  Apim\ACYPI003826   Bombyx mori Silkmoth  Bmor\BGIBMGA014271   Pediculus humanus Human body louse  Phum\PHUM227560   Tribolium castaneum Red flour beetle  Tcas\TC001089
Orthologs in non-Insect Arthropods (EOG698SFX)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\cytb   Ixodes scapularis Deer tick  Isca\ISCW009014
Orthologs in non-Arthropod Metazoa (EOG6M9DK1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\C24H12.4   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_012487gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008946gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_014505gn   Danio rerio Zebrafish  Drer\ddx56   Xenopus tropicalis Western clawed frog  Xtro\ddx56   Mus musculus House mouse  Mmus\Ddx56   Rattus norvegicus Norway rat  Rnor\Ddx56   Homo sapiens Human  Hsap\DDX56
Human Orthologs (1)
Gene OMIM HGNC Hsap\DDX56
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD15498 Drosophila sechellia Dsec\GM22625 Drosophila erecta Dere\GG17541 Drosophila yakuba Dyak\GE15300 Drosophila ananassae Dana\GF21359 Drosophila pseudoobscura pseudoobscura Dpse\GA14086 Drosophila persimilis Dper\GL15985 Drosophila willistoni Dwil\GK24230 Drosophila virilis Dvir\GJ15568 Drosophila mojavensis Dmoj\GI21708 Drosophila grimshawi Dgri\GH24281
Stocks & Reagents
Stocks Listed in FlyBase ( 13 )
Bloomington	4731 Hlc19Ff-7/FM6 6889 Hlc19Ff-1/FM6 18982 w1118 PBac{WH}Hlcf06483 7485 Hlc19Ff-2/FM6/Dp(1;Y)mal+ 7423 Hlc17-62/Binsn/Dp(1;Y)mal+ 28991 y1 v1; P{TRiP.JF02921}attP2 e* 35308 y1 sc* v1; P{TRiP.HMS01424}attP2
Harvard	- PBac{WH}Hlcf03964 - PBac{WH}Hlcf06483
VDRC	v32693 w1118; P{GD9183}v32693 v32694 w1118; P{GD9183}v32694 v50144 w1118; P{GD16441}v50144/CyO
	More stocks available...
Genomic Clones ( 2 )
	BACR09F10 BACR23I18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 131 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE72861 RH74035
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH11253 GH21675 GM02417 GM04394 GM10217 LD01242 LD02933 LD06142 LD08240 LD09016 LD10586 LD11970 LD12802 LD12878 LD13516 LD14457 LD23659 LD24354 LD30615 LD32709 LD32780 LD33048 LD33750 LD34174 LD35262 LD35266 LD35301 LD37113 LD40233 LD40334 LD40744 LD41456 LD42162 LD43007 LD43539 LD44237 LD45691 LD46153 LD46696 LD46825 LD47975 LP06630 LP08369 LP18804 LP22183 LP24211 RE04639 RE04959 RE05010 RE11613 RE19455 RE29361 RE29915 RE34254 RE39226 RE49082 RE55132 RE56134 RE66845 RE67493 RE72435 RE72690 RE72806 RE73480 RE74327 RH02305 RH02332 RH03286 RH10725 RH11121 RH22257 RH26412 RH29714 RH36739 RH36804 RH38511 RH38557 RH42625 RH45051 RH58405 RH64633 RH70360 RH71975 RH72459 RH73908 RH74445 RH74478 SD09027 SD13240 SD17413 SD18563 SD21856 SD24783
Other clones	77612 100181 106672 214281.64 214437.77 CK01.1C.F9 CK01.1C.F11 CK01.51C.C8 CK01.60A.F3 CK01.76D.E5 CK01.104A.H9 CK01.110A.H12 Dmel_dig_009714_0660_1808 Dmel_neb_013865_0084_1296 EC34342 EC051628 EC052121 EC052643 EC056412 EK040844 EK060019 EK063322 EK067803 EK099462 EK208448 EK223049 EK244256 EN15353 EP18643 EP19122 FGC030B10 IP10929 IP11029 IP11129 IP13179 RE01119
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0001565 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33118
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Hlc CG1666 (Li, 1999.11)
Source for database merge of
Additional comments
Other Comments
	snoRNA:Z30 is an intronic RNA encoded in the first intron of Hlc. (Zhou et al., 2002) Mutant embryos have no obvious defects of central nervous system, peripheral nervous system, or cuticle. Germ line clones lethal (Perrimon, Smouse, and Miklos, 1989).
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078710 RefSeq (Proteins) • NP_523434 DDBJ / EMBL / GenBank • AAC28406 AAF50818 AAL48095 AAM29646 AF017777 AY070624 AY113641 BI578914 BI607049 CZ486560 CZ486561 Entrez Gene - A searchable database of RefSeq genes. • 33118 UniProtKB/TrEMBL • Q8MYS0 Q9VRI0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Helicase, C-terminal (IPR001650) DNA/RNA helicase, DEAD/DEAH box type, N-terminal (IPR011545) Helicase, superfamily 1/2, ATP-binding domain (IPR014001) RNA helicase, DEAD-box type, Q motif (IPR014014) P-loop containing nucleoside triphosphate hydrolase (IPR027417)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0001565 DRSC - Results from RNAi screens. • FBgn0001565 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001565 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1666-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0001565 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33118 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33118 modMine - Data generated by the modENCODE project. • FBgn0001565
Synonyms & Secondary IDs ( 24 )
Reported As
Symbol Synonym	7 (Lifschytz and Falk, 1968) 11P1 (Kramers et al., 1991, Schalet, 1986) 14 (Lifschytz and Falk, 1969) A112 (Miklos et al., 1997, Maleszka et al., 1996, Prud'homme et al., 1995, Miklos et al., 1987, Hayward et al., 1993, Miklos and de Couet, 1990, Miklos and Cotsell, 1990, Perrimon et al., 1989, Lefevre and Watkins, 1986, Eeken et al., 1985, Rahman and Lindsley, 1981, Lefevre, 1981, Lifschytz, 1978, Bergman et al., 2006) CG1666 (Huang et al., 2005, Perkins et al., 2009, Ni et al., 2011.7.19) DmRH10 (Boudet et al., 2001) HLC (Boudet et al., 2001) hlc (Miklos, 1997.8.4, Hyun et al., 2005) Hlc (Neumüller et al., 2011, Japanese National Institute of Genetics, 2012.5.21) HM-44 (Kramers et al., 1991) l11P1 (Schalet and Singer, 1971) l(1)8-1   l(1)11P1 (Rahman and Lindsley, 1980) l(1)19Ff   l(1)A112 (Schalet, 1972, Miklos et al., 1987) l(1)S-19F6   lA112 (Schalet and Singer, 1971) unnamed (Schalet and Lefevre, 1973)
Name Synonym	helicase (Maleszka et al., 1998) Helicase (Meiklejohn et al., 2011) lethal(1)19Ff   RNA helicase gene (Zhou et al., 2002) section 7 (Lifschytz and Falk, 1968) section 14 (Lifschytz and Falk, 1969)
Secondary FlyBase IDs
References ( 61 )
Generate a list of	All references relating to this gene ( 61 )
List References by type	Research paper  ( 34 ) Supplementary material  ( 4 ) Review  ( 2 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 1 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 1 ) Curated genome annotation  ( 3 ) Book  ( 1 )
Recent research papers ( 2 )
	Meiklejohn et al., 2011, PLoS Biol. 9(8): e1001126 Sex Chromosome-Specific Regulation in the Drosophila Male Germline But Little Evidence for Chromosomal Dosage Compensation or Meiotic Inactivation. [FBrf0214756] Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...