Dgrip91, dd4, l(1)dd4, l(1)d.deg.-4, lethal (1) discs degenerate 4
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Gene model reviewed during 5.45
3.491 (longest cDNA)
There is only one protein coding transcript and one polypeptide associated with this gene
917 (aa); 100 (kD observed)
Gamma-tubulin small complex (Gamma TuSC) is a heterotetrameric complex which contains two molecules of gamma-tubulin, and one molecule each of Dgrip84 and Dgrip91. The gamma-tubulin in this complex binds preferentially to GDP over GTP.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Grip91 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signals
View Dmel\Grip91 in GBrowse 21-45
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: Grip91 l(1)dd4
Source for merge of: Grip91 l(1)dd4
Source for merge of: l(1)dd4 l(1)G0122
Source for merge of: l(1)dd4 anon-WO03040301.197
Renamed from the placeholder symbol 'l(1)dd4' to 'Grip91' to reflect usage in the literature.
Source for merge of l(1)dd4 anon-WO03040301.197 was sequence comparison ( date:051113 ).
RNAi screen using dsRNA made from templates generated with primers directed against this gene results in the formation of an aberrantly long, monopolar spindle when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.
The interactions between and γ-Tubulin facilitates γ-Tubulin binding to GTP.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
l(1)dd4 is essential for progression through mitosis.
Identification: Protein identified as part of a γ tubulin ring complex.