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General Information
Symbol
Dmel\dlg1
Species
D. melanogaster
Name
discs large 1
Annotation Symbol
CG1725
Feature Type
FlyBase ID
FBgn0001624
Gene Model Status
Stock Availability
Enzyme Name (EC)
Guanylate kinase (2.7.4.8)
Gene Snapshot
In progress.Contributions welcome.
Also Known As
Dlg, Discs large, Discs-large, Disc large, l(1)d.lg-1
Key Links
Genomic Location
Cytogenetic map
Sequence location
X:11,369,665..11,409,776 [+]
Recombination map
1-34
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
Belongs to the MAGUK family. (P31007)
Molecular Function (GO)
[Detailed GO annotations]
Catalytic Activity (EC)
Experimental Evidence
-
Predictions / Assertions
ATP + GMP = ADP + GDP (2.7.4.8)
Summaries
Gene Group (FlyBase)
PHOSPHATE GROUP PHOSPHOTRANSFERASES -
Phosphate group phosphotransferases catalyze the transfer of a phosphorus-containing group from a donor compound to an acceptor.
Protein Function (UniProtKB)
During embryonic development, some isoforms are essential for proper neuronal differentiation and organization. Required for cell polarity; maintenance of apicobasal polarity. Plays a critical role at septate junctions in cellular growth control during larval development. The presence of a guanylate kinase domain suggests involvement in cellular adhesion as well as signal transduction to control cellular proliferation.
(UniProt, P31007)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
dlg1: discs large
Late larval lethal; prolonged larval stages with bloated larvae attempting pupariation around day 15; some cuticular tanning, but no adult cuticular structures formed. During early larval development, the imaginal discs are smaller than those of normal larvae of the same age and are misshapen, but as the larvae continue to survive after the normal pupariation time, the discs continue to grow. They become large, amorphous, and solid, containing three times the normal numbers of cells at ten days of age; they also experience substantial cell death. By eleven days, wing and haltere discs may fuse; also first and second leg discs fuse with ventral ganglion of the CNS; great enlargement of optic lobes of brain also takes place. Discs, but not brains, transplanted into adults grow rapidly displaying invasive growth; they do not differentiate when transplanted into larvae for metamorphosis. Homozygous tissues do not survive, nor do gynandromorphs (one with male abdominal tissue vs. 66 expected). It is possible to produce homozygous germ-line clones (Perrimon). dlg1 embryos generated from such clones display defects in morphogenesis and neurogenesis; most tissues are defective; partial rescue achieved by a paternal dlg1+ contribution, in the form of either a normal X or a v+Y.
dlg12
Homozygotes fail to survive when raised at 25; when raised at 18 however, 37% survival attained; hemizygous females show 65-70% survival at 18, but are also lethal at 25. Survival at 18 nearly complete in heterozygotes with dlg15 and dlg118, and survival at 25 is 4% and 95% respectively. Embryos produced by matings between surviving dlg12 flies raised at 18 show but 4% hatchability at 18, and such crosses are completely sterile at 25; however in crosses of homozygous dlg1+2 females to dlg1+ males, rescue of heterozygous daughters nearly complete at either 18 or 25 and is somewhat reduced at 29. Abnormal embryos produced by dlg12 females show failure of dorsal closure, and head involution. The maternal effect of dlg1 is germ-line specific, since embryos produced by homozygous clones in heterozygous mothers are indistinguishable from those produced by homozygous mothers (Perrimon, 1988, Dev. Biol. 127: 392-407).
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
21
Number of Unique Polypeptides
15

Please see the GBrowse view of Dmel\dlg1 or the JBrowse view of Dmel\dlg1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.44
Stop-codon suppression (UGA) postulated; FBrf0216884.
gene_with_stop_codon_read_through ; SO:0000697
Gene model includes transcripts encoding non-overlapping portions of the full CDS.
Gene model reviewed during 5.40
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0073486
4865
968
FBtr0073488
5296
970
FBtr0073483
2554
208
FBtr0073485
4848
960
FBtr0073487
4709
960
FBtr0073484
2554
816
FBtr0073489
4893
975
FBtr0073490
5119
911
FBtr0073491
2114
208
FBtr0073492
2102
208
FBtr0112812
6554
911
FBtr0112813
7249
946
FBtr0301288
3196
1030
FBtr0301289
4841
960
FBtr0302114
2363
206
FBtr0308088
4841
983
FBtr0308089
5341
975
FBtr0330390
4848
1001
FBtr0333261
5380
960
FBtr0333262
6815
943
FBtr0333263
2524
198
Additional Transcript Data and Comments
Reported size (kB)
5.1 (longest cDNA)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0073342
103.2
968
8.49
FBpp0089351
106.7
970
6.75
FBpp0073339
24.4
208
10.43
FBpp0073341
102.4
960
7.87
FBpp0089350
102.4
960
7.87
FBpp0073340
88.7
816
4.49
FBpp0089352
104.0
975
7.15
FBpp0089353
100.2
911
6.95
FBpp0089348
24.4
208
10.43
FBpp0089349
24.4
208
10.43
FBpp0111724
100.5
911
8.77
FBpp0111725
104.3
946
6.61
FBpp0290503
112.5
1030
4.80
FBpp0290504
102.4
960
7.87
FBpp0291324
24.2
206
10.43
FBpp0300431
104.9
983
7.56
FBpp0300432
104.0
975
7.15
FBpp0303416
106.8
1001
8.95
FBpp0305459
102.4
960
7.87
FBpp0305460
100.6
943
9.06
FBpp0305461
23.3
198
10.43
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

208 aa isoforms: dlg1-PC, dlg1-PI, dlg1-PJ
975 aa isoforms: dlg1-PG, dlg1-PQ
960 aa isoforms: dlg1-PD, dlg1-PE, dlg1-PN, dlg1-PS
Additional Polypeptide Data and Comments
Reported size (kDa)
960 (aa); 102 (kD)
Comments
External Data
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\dlg1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (64 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
inferred from physical interaction with FLYBASE:gukh; FB:FBgn0026239
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
Biological Process (38 terms)
Terms Based on Experimental Evidence (28 terms)
CV Term
Evidence
References
inferred from mutant phenotype
(assigned by BHF-UCL )
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by BHF-UCL )
inferred from mutant phenotype
(assigned by BHF-UCL )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by BHF-UCL )
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by BHF-UCL )
inferred from mutant phenotype
(assigned by BHF-UCL )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by BHF-UCL )
inferred from mutant phenotype
(assigned by BHF-UCL )
inferred from mutant phenotype
(assigned by BHF-UCL )
Terms Based on Predictions or Assertions (13 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN001501163
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000563569
(assigned by GO_Central )
traceable author statement
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN001501163
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN001501163
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN001501163
(assigned by GO_Central )
Cellular Component (23 terms)
Terms Based on Experimental Evidence (17 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from high throughput direct assay
inferred from direct assay
inferred from high throughput direct assay
inferred from mutant phenotype
inferred from direct assay
colocalizes_with postsynaptic membrane
inferred from direct assay
colocalizes_with presynaptic membrane
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
Terms Based on Predictions or Assertions (9 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN001501163
(assigned by GO_Central )
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN001501163
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN001501163
(assigned by GO_Central )
traceable author statement
inferred from biological aspect of ancestor with PANTHER:PTN000563569
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000563569
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN000563569
(assigned by GO_Central )
traceable author statement
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
dlg1 has an unusual gene structure encoding isoforms with non-overlapping coding regions. Probes specific to the amino-terminal transcripts of dlg1 detect transcripts starting in embryonic stage 10 in the neurogenic region. In stage 12, expression becomes more concentrated in the ventral nerve cord and persists throughout embryogenesis.
dlg1 transcripts are expressed throughout development.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
dlg1 is expressed in Malpighian tubule Type II (stellate) cells in early stage 13 embryos, just after they have pushed into the renal epithelium. All Malpighian tubule Type II cells contact the luminal surface of the tubules in mid stage 14 and express high levels of dlg1 as well as crb, shg, and baz.
dlg1 is expressed in central brain neuropils. Lamina cross-sections exhibited a bright ring of R1-R6 terminals that label with dlg1. Using immunoelectron microscopy, dlg1 is often seen close to the heads of the capitate projections (invaginations from surrounding epithelial glial and specialised organelles for the endocytosis of vesicle membrane), but not the stalks.
dlg1 protein is found mainly in epithelia, where it is localized at the apical part of the lateral cell membrane.
Expression of dlg1 is observed in the neuromuscular junction of wildtype fly at 3, 15, 30 and 60 days post-eclosion.
In the adult prothorax and neck, dlg1 immunoreactivity is observed in the type I boutons of motor neurons innervating ventral cervical muscles, prothoracic sternal anterior rotator muscle 31, and prothoracic sternal adductor muscle 33. dlg1 protein is localized to all prothoracic type I nerve terminals. Extrasynaptic dlg1 immunoreactivity is also observed in all adult muscles in a highly regular pattern resembling a reticular network.
In male reproductive tissue, dlg1 protein is found in the apical region of the lateral membranes of the accessory gland and the ejaculatory bulb. A complex pattern of staining is seen also in the testis. In the ovary, staining is observed in lateral membranes of follicle cells and in the cytoplasm of nurse cells and the oocyte. In cellular blastoderm embryos, dlg1 protein is found at the apical region of the forming lateral cell membrane. It is around each cell but not at the corners. At the time of dorsal closure, staining in the epidermis is restricted along the cell boundaries. Staining is seen in peripheral neurons, in gut, and in axon bundles. In larvae, dlg1 protein is found in salivary glands, proventriculus, imaginal discs, and CNS.
Marker for
Subcellular Localization
CV Term
Evidence
References
inferred from direct assay
inferred from high throughput direct assay
inferred from direct assay
inferred from high throughput direct assay
inferred from mutant phenotype
inferred from direct assay
colocalizes_with postsynaptic membrane
inferred from direct assay
colocalizes_with presynaptic membrane
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
inferred from direct assay
Expression Deduced from Reporters
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\dlg1 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 69 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 44 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of dlg1
Transgenic constructs containing regulatory region of dlg1
Deletions and Duplications ( 39 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
imaginal disc & epithelial cell & plasma membrane | somatic clone
imaginal disc & epithelial cell & septate junction | somatic clone
imaginal disc & septate junction
neuromuscular junction & bouton
neuromuscular junction & postsynaptic membrane
postsynaptic membrane & neuromuscular junction | larval stage
presynaptic membrane & neuromuscular junction | larval stage
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (11)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
13 of 15
Yes
Yes
12 of 15
Yes
No
12 of 15
Yes
No
 
9 of 15
Yes
No
1 of 15
Yes
No
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (10)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
13 of 15
Yes
Yes
12 of 15
Yes
No
11 of 15
Yes
No
9 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
Yes
No
Rattus norvegicus (Norway rat) (9)
11 of 13
Yes
Yes
10 of 13
Yes
No
9 of 13
Yes
No
6 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (6)
10 of 12
Yes
Yes
3 of 12
No
Yes
3 of 12
No
Yes
2 of 12
No
Yes
1 of 12
No
Yes
1 of 12
No
No
Danio rerio (Zebrafish) (11)
11 of 15
Yes
Yes
11 of 15
Yes
Yes
10 of 15
No
Yes
10 of 15
No
Yes
8 of 15
No
Yes
7 of 15
No
Yes
1 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
Yes
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (3)
11 of 15
Yes
Yes
1 of 15
No
Yes
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (1)
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (1)
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091901DA )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila sechellia
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150DOP )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Musca domestica
House fly
Musca domestica
House fly
Musca domestica
House fly
Glossina morsitans
Tsetse fly
Lucilia cuprina
Australian sheep blowfly
Aedes aegypti
Yellow fever mosquito
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0759 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X070C )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Stegodyphus mimosarum
African social velvet spider
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0BB1 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Ciona intestinalis
Vase tunicate
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (9)
2 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 6 )
Potential Models Based on Orthology ( 1 )
Modifiers Based on Experimental Evidence ( 4 )
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Functional Complementation Data
Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
Interactions
Summary of Physical Interactions
esyN Network Diagram
Show neighbor-neighbor interactions:
Select Layout:
Legend:
Protein
RNA
Selected Interactor(s)
Interactions Browser

Please see the Physical Interaction reports below for full details
protein-protein
Physical Interaction
Assay
References
RNA-RNA
Physical Interaction
Assay
References
RNA-protein
Physical Interaction
Assay
References
Summary of Genetic Interactions
esyN Network Diagram
esyN Network Key:
Suppression
Enhancement

Please look at the allele data for full details of the genetic interactions
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
Starting gene(s)
Interaction type
Interacting gene(s)
Reference
External Data
Linkouts
BioGRID - A database of protein and genetic interactions.
DroID - A comprehensive database of gene and protein interactions.
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Pathways
Gene Group - Pathway Membership (FlyBase)
External Data
Linkouts
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
SignaLink - A signaling pathway resource with multi-layered regulatory networks.
Genomic Location and Detailed Mapping Data
Chromosome (arm)
X
Recombination map
1-34
Cytogenetic map
Sequence location
X:11,369,665..11,409,776 [+]
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
10B6-10B10
Limits computationally determined from genome sequence between P{EP}CG11756EP1610 and P{EP}CG32666EP1452
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
10B14-10B17
(determined by in situ hybridisation) 10B8--11 (determined by in situ hybridisation)
10B8-10B11
(determined by in situ hybridisation)
10B14-10B17
(determined by in situ hybridisation)
Experimentally Determined Recombination Data
Left of (cM)
Right of (cM)
Notes
Stocks and Reagents
Stocks (43)
Genomic Clones (25)
cDNA Clones (141)
 

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences
Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)
RNAi and Array Information
Linkouts
DRSC - Results frm RNAi screens
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
Antibody Information
Laboratory Generated Antibodies
Commercially Available Antibodies
 
Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
Other Information
Relationship to Other Genes
Source for database identify of
Source for identity of: dlg1 CG1725
Source for database merge of
Source for merge of: dlg1 l(1)G0276 l(1)G0456 l(1)G0342
Source for merge of: dlg1 anon- EST:Posey93
Source for merge of: dlg1 anon-WO03040301.258 anon-WO03040301.260 anon-WO03040301.268
Source for merge of: dlg1 CG1730
Additional comments
Annotations CG1725 and CG1730 merged as CG1725 in release 3 of the genome annotation.
Source for merge of dlg1 anon-WO03040301.258 anon-WO03040301.260 anon-WO03040301.268 was sequence comparison ( date:051113 ).
Other Comments
RNAi interference against the dlg1 S97 isoform does not result in defects in the development of the nervous system. The defects in the development of the nervous system that were reported in FBrf0159063 after injection of a dsRNA directed against the dlg1 S97 isoform were not due to an affect on the dlg1 S97 isoform, but instead were unintended off-target effects caused by a low-complexity fragment of less than 50bp at the end of the RNAi construct.
dlg1 protein is required for the microtubule-induced cortical polarity of the raps and G-iα65A proteins in neuroblasts.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Vap-33-1 and dlg1 localize asymmetrically at the synapse during bouton budding.
baz, raps and dlg1 establish and maintain planar polarity in pI cells.
The l(2)gl and dlg1 products act in a common process that differentially mediates cortical protein targeting in mitotic neuroblasts, creating intrinsic differences between daughter cells.
The dlg1 product regulates the localization of l(2)gl.
The l(2)gl and dlg1 gene products regulate basal protein targeting, but not apical complex formation or spindle orientation, in both embryonic and larval neuroblasts. The l(2)gl and dlg1 proteins promote, and that of zip inhibits, actomyosin dependent basal protein targeting in neuroblasts.
dlg1 and CaMKII protein colocalise at synapses and exist in the same protein complex.
Functional analysis of the MAGUK domains of dlg1 in vivo.
The dlg1 gene product is not required for the localization of glutamate receptors at synapses.
The dlg1 product colocalises with Sh K+ channels, which are clustered at glutamatergic synapses at the larval neuromuscular junction. Results demonstrate dlg1 plays an important role in synaptic organisation in vivo that correlates with its ability to bind directly to specific membrane proteins of the synapse.
Some of the proteins of apico-lateral junctions are required both for apico-basal cell polarity and for the signalling mechanisms controlling cell proliferation, whereas others are required more specifically in cell-cell signalling.
The C-terminal sequences of Fas2 and Sh are both necessary and sufficient for targeting to the subsynaptic muscle membrane at the larval neuromuscular junction, and this localization depends on the product of dlg1.
Mutations in dlg1 can result in postsynaptic structural defects and large synaptic currents at neuromuscular junctions. Targetted expression of dlg1 using Scer\GAL4 can substantially rescue the reduced postsynaptic structure and presynaptic expression can rescue the physiological defect. Levels of postsynaptic dlg1 regulate or determine subsynaptic reticulum (SSR) size. Results suggest that dlg1 functions in the regulation of neurotransmitter release and postsynaptic structure.
The expression of dlg1 during synaptogenesis and synapse maturation has been studied.
dlg1 protein is localised on the cytoplasmic face of the septate junction and is required for the maintenance of this structure. dlg1 is also required for proper organisation of the cytoskeleton, for the differential location of membrane proteins and for apicobasal polarity of epithelial cells. These functions can be uncoupled from dlg1s role as a tumour suppressor since mutations in two domains of the protein (SH3 and GUK) cause loss of normal cell proliferation control without affecting the other functions of the protein.
Drosophila homolog of rat PSD-95.
In addition to its function as a tumor suppressor, the dlg1 gene is required for proper formation of neuromuscular synapses.
dlg1 immunoreactivity is expressed at one type of glutamatergic synapse and is associated with both presynaptic and postsynaptic membranes. Mutations in dlg1 alter the expression and cause striking changes in the structure of the subsynaptic reticulum, a postsynaptic specialisation at these synapses. Results indicate that dlg1 is required for normal synaptic structure.
Mutants display an imaginal disc neoplastic phenotype.
Endocrine mechanisms responsible for the prolongation of larval life in dlg1 mutants have been investigated: results suggest that delayed pupariation is caused by the overgrown imaginal discs inhibiting the production or release of ecdysteroids from the endocrine system.
Reduced ecdysteroid titer and delayed or blocked metamorphosis in mutants may be a result of altered neuropeptide production, which is probably secondary to the imaginal disc overgrowth.
Mutant analysis of dlg1 suggests that cell-cell interaction and communication is required for the termination of disc cell proliferation. This must occur prior to cellular response to ecdysone.
Mutations cause neoplastic imaginal overgrowth.
A protein, PSD-95, similar to the dlg1 tumour suppressor protein has been found in the rat brain. dlg1 protein is associated with septate junctions in developing flies and contains a guanylate kinase domain that is required for normal control of cell division.
Mutant analysis demonstrates that the dlg1 gene product is a guanylate kinase homolog located in a small apical belt of the lateral cell membrane coinciding in position with the septate junction.
dlg1 has been isolated and characterized.
The developmental profile of dlg1 transcription has been investigated.
Late larval lethal; prolonged larval stages with bloated larvae attempting pupariation around day 15; some cuticular tanning, but no adult cuticular structures formed. During early larval development, the imaginal discs are smaller than those of normal larvae of the same age and are misshapen, but as the larvae continue to survive after the normal pupariation time, the discs continue to grow. They become large, amorphous and solid, containing three times the normal numbers of cells at ten days of age; they also experience substantial cell death. By eleven days, wing and haltere discs may fuse; also first and second leg discs fuse with ventral ganglion of the CNS; great enlargement of optic lobes of brain also takes place. Discs, but not brains, transplanted into adults grow rapidly displaying invasive growth; they do not differentiate when transplanted into larvae for metamorphosis. Homozygous tissues do not survive, nor do gynandromorphs (one with male abdominal tissue vs. 66 expected). It is possible to produce homozygous germ-line clones (Perrimon, 1988). dlg1 embryos generated from such clones display defects in morphogenesis and neurogenesis; most tissues are defective; partial rescue achieved by a paternal dlg1+ contribution, in the form of either a normal X or a v+Y.
Origin and Etymology
Discoverer
Etymology
Identification
External Crossreferences and Linkouts ( 156 )
Sequence Crossreferences
NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
Other crossreferences
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
KEGG Genes - Molecular building blocks of life in the genomic space.
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
modMine - A data warehouse for the modENCODE project
SignaLink - A signaling pathway resource with multi-layered regulatory networks.
Linkouts
BioGRID - A database of protein and genetic interactions.
DPiM - Drosophila Protein interaction map
DroID - A comprehensive database of gene and protein interactions.
DRSC - Results frm RNAi screens
Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyMine - An integrated database for Drosophila genomics
Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
MIST (genetic) - An integrated Molecular Interaction Database
MIST (protein-protein) - An integrated Molecular Interaction Database
Synonyms and Secondary IDs (66)
Reported As
Symbol Synonym
DLG
(Dissel et al., 2017, Zhang et al., 2017, Nakayama et al., 2016, Xu et al., 2016, Chin et al., 2015, Dissel et al., 2015, Packard et al., 2015, Peterson and Krasnow, 2015, Blunk et al., 2014, Mhatre et al., 2014, Nakayama et al., 2014, Xing et al., 2014, Forrest et al., 2013, Friedman et al., 2013, Gillespie and Hodge, 2013, Grifoni et al., 2013, Jepson et al., 2013, Jokhi et al., 2013, Lee et al., 2013, Lin et al., 2013, Nahm et al., 2013, Weislogel et al., 2013, Xu et al., 2013, Younger et al., 2013, Baffet et al., 2012, Beck et al., 2012, Coffee et al., 2012, Dani et al., 2012, Füger et al., 2012, Harvey and Hariharan, 2012, Lloyd et al., 2012, Pradhan et al., 2012, Rushton et al., 2012, Beerman and Jongens, 2011, Chiang et al., 2011, Gibson et al., 2011, Godena et al., 2011, Lanson et al., 2011, Miśkiewicz et al., 2011, Shih and Chiang, 2011, Siller and Broadie, 2011, Uytterhoeven et al., 2011, Varija Raghu et al., 2011, Wu et al., 2011, Zhang et al., 2011, Choi et al., 2010, Coffee et al., 2010, Hamanaka and Meinertzhagen, 2010, Haussmann and Soller, 2010, Kim et al., 2010, Milton et al., 2010, Morimoto et al., 2010, Mosca and Schwarz, 2010, Dickman and Davis, 2009, Fuentes-Medel et al., 2009, Gilestro et al., 2009, Korkut et al., 2009, Kumar et al., 2009, Morais et al., 2009, Ramachandran et al., 2009, Rushton et al., 2009, von Trotha et al., 2009, Cauchi et al., 2008, Chang et al., 2008, Kapelnikov et al., 2008, Kolodziejczyk et al., 2008, Liebl et al., 2008, Pan et al., 2008, Ratnaparkhi et al., 2008, Venken et al., 2008, Ash et al., 2007, Beramendi et al., 2007, Haas et al., 2007, Kazama et al., 2007, Ohyama et al., 2007, Acharya et al., 2006, Ashraf et al., 2006, Ataman, 2006, Bhandari et al., 2006, Dickman, 2006, Dickman et al., 2006, Hebbar et al., 2006, Thompson and Cohen, 2006, Wang et al., 2006, Chen and Featherstone, 2005, Hiesinger et al., 2005, Liebl et al., 2005, Margolis and Borg, 2005, Pallavi and Shashidhara, 2005, Singh et al., 2005, Montana and Littleton, 2004, Rivlin et al., 2004, Rosin et al., 2004, Aravamudan and Broadie, 2003, Benton and St. Johnston, 2003, Cereijido et al., 2003, Genova and Fehon, 2003, Packard et al., 2003, Rieckhof et al., 2003, Rushton et al., 2003, Schenck et al., 2003, Van Doren et al., 2003, Beumer et al., 2002, Kazantsev et al., 2002, Koh et al., 2002, Packard et al., 2002, Radovic et al., 2002, Ruiz-Canada et al., 2002, Beumer et al., 2001, Mathew et al., 2001, Parmentier et al., 2001, Razzaq et al., 2001, Renden et al., 2001, Bellen, 2000, Kramer, 2000, Seidensticker and Behrens, 2000, Beumer et al., 1999, Bhat et al., 1999, Gorczyca et al., 1999, Koh et al., 1999, Koh et al., 1999, Murthy, 1999, Parmentier et al., 1999, Montell, 1998, O'Brien et al., 1998, Baumgartner et al., 1996, Roush, 1996)
Dlg
(Hannaford et al., 2019, Khadilkar and Tanentzapf, 2019, Magnaghi-Jaulin et al., 2019, Nakajima et al., 2019, Ou et al., 2019, Caria et al., 2018, Gan and Zhang, 2018, Schmidt et al., 2018, Wang et al., 2018, Zoranovic et al., 2018, Choubey and Roy, 2017, Furuse and Izumi, 2017, Golub et al., 2017, Jouette et al., 2017, Lang and Munro, 2017, Richardson and Portela, 2017, Clavería and Torres, 2016, Di Gregorio et al., 2016, Flores-Benitez and Knust, 2016, Jin et al., 2016, Krieger et al., 2016, Lee and Schwarz, 2016, Moreira and Morais-de-Sá, 2016, Ng et al., 2016, Padash Barmchi et al., 2016, Padash Barmchi et al., 2016, Patel et al., 2016, Roman-Fernandez and Bryant, 2016, Schimizzi et al., 2016, Sharifkhodaei et al., 2016, Veeman and McDonald, 2016, Yadav et al., 2016, Bajaj et al., 2015, Bell et al., 2015, Bouleau and Tricoire, 2015, Cao et al., 2015, de Madrid et al., 2015, Erdmann et al., 2015, Flores-Benitez and Knust, 2015, Harris and Littleton, 2015, Hildebrandt et al., 2015, Irvine and Harvey, 2015, Kim et al., 2015, Lee et al., 2015, Ohno et al., 2015, Ramos et al., 2015, Romano et al., 2015, Schweisguth, 2015, Wang et al., 2015, Wang et al., 2015, Zhou et al., 2015, Acharya et al., 2014, Amoyel and Bach, 2014, Bätz et al., 2014, Bulat et al., 2014, Claret et al., 2014, Coyle, 2014, Davis et al., 2014, Gamblin et al., 2014, Ghosh et al., 2014, Jones and Srivastava, 2014, Kumichel and Knust, 2014, Liang et al., 2014, Loya et al., 2014, Macagno et al., 2014, Machamer et al., 2014, Mauri et al., 2014, Morais-de-Sá et al., 2014, Mouri et al., 2014, Oliva et al., 2014, Perruchoud and Egger, 2014, Romano et al., 2014, Sulkowski et al., 2014, Thomas and Strutt, 2014, Wang et al., 2014, Wang et al., 2014, Bergstralh et al., 2013, Castellanos et al., 2013, Chen and Zhang, 2013, Das et al., 2013, Denholm et al., 2013, Eguchi et al., 2013, Enneking et al., 2013, Estes et al., 2013, Fuse et al., 2013, Haack et al., 2013, Kern et al., 2013, Klose et al., 2013, Lee and Harris, 2013, Lee et al., 2013, Levayer and Moreno, 2013, Lu and Johnston, 2013, Lu and Prehoda, 2013, Maisak et al., 2013, Maldonado et al., 2013, Masoner et al., 2013, Morante et al., 2013, Nakamura et al., 2013, Natarajan et al., 2013, Pérez-Gómez et al., 2013, Rohrbough et al., 2013, Rousso et al., 2013, Sotillos et al., 2013, Steffensmeier et al., 2013, Sung et al., 2013, Tögel et al., 2013, Woodfield et al., 2013, Yan et al., 2013, Yu and Guan, 2013, Zhou and Luo, 2013, Andersen et al., 2012, Baffet et al., 2012, Bayat et al., 2012, Colombani et al., 2012, Etchegaray et al., 2012, Fletcher et al., 2012, Giagtzoglou et al., 2012, Gomez et al., 2012, Guilgur et al., 2012, Gurudatta et al., 2012, Jordán-Álvarez et al., 2012, Kelsom and Lu, 2012, Kim et al., 2012, Koch et al., 2012, Koles et al., 2012, Liu et al., 2012, Maiya et al., 2012, Miller et al., 2012, Mosca et al., 2012, Mouri et al., 2012, Muller et al., 2012, Muñoz-Soriano et al., 2012, Neumüller et al., 2012, Penalva and Mirouse, 2012, Rawson et al., 2012, Sarpal et al., 2012, Sen et al., 2012, Smith et al., 2012, Stevens et al., 2012, Tepass, 2012, Tsai et al., 2012, Unhavaithaya and Orr-Weaver, 2012, Vanderploeg et al., 2012, Verghese et al., 2012, Wang et al., 2012, Xia et al., 2012, Xiao et al., 2012, Zhou and Hong, 2012, Ayyub, 2011, Charlton-Perkins et al., 2011, Cho et al., 2011, Daniels et al., 2011, Djiane et al., 2011, Estes et al., 2011, Genevet and Tapon, 2011, Gilbert et al., 2011, Godena et al., 2011, Graf et al., 2011, Haralalka et al., 2011, Hijazi et al., 2011, James and Broihier, 2011, Jiang et al., 2011, Kaplan et al., 2011, Keller et al., 2011, Laprise and Tepass, 2011, Lee and Thomas, 2011, Mathew et al., 2011, Miles et al., 2011, Müller et al., 2011, Pastor-Pareja and Xu, 2011, Popova et al., 2011, Raghu and Borst, 2011, Rossetto et al., 2011, Sarthi and Elefant, 2011, Singh et al., 2011, Sun et al., 2011, Szul et al., 2011, Takemura et al., 2011, Tapadia and Gautam, 2011, Tare et al., 2011, Tjota et al., 2011, Wang et al., 2011, Wang et al., 2011, Wang et al., 2011, Willecke et al., 2011, Xu et al., 2011, Zhao et al., 2011, Ball et al., 2010, Banovic et al., 2010, Bayraktar et al., 2010, Beam and Moberg, 2010, Campbell et al., 2010, Chen et al., 2010, David et al., 2010, Ekas et al., 2010, Estella and Mann, 2010, Fan et al., 2010, Fernandes et al., 2010, Georgiou and Baum, 2010, Gervais and Casanova, 2010, Graham et al., 2010, Haglund et al., 2010, Hamel et al., 2010, Harumoto et al., 2010, Ho et al., 2010, Januschke and Gonzalez, 2010, Kaplan and Tolwinski, 2010, Khuong et al., 2010, Krahn et al., 2010, Laplante et al., 2010, Lee et al., 2010, Levine et al., 2010, Liu et al., 2010, Lorenzo et al., 2010, Marie et al., 2010, Maurel-Zaffran et al., 2010, Maynard et al., 2010, Morais-de-Sá et al., 2010, Murthy et al., 2010, Nahm et al., 2010, Nahm et al., 2010, Nelson et al., 2010, Padash-Barmchi et al., 2010, Robinson et al., 2010, Rohrbough and Broadie, 2010, Sekyrova et al., 2010, Singh et al., 2010, Tamori et al., 2010, Tikhmyanova et al., 2010, Tiklova et al., 2010, Tiklová et al., 2010, Tsurudome et al., 2010, Warner et al., 2010, Yu et al., 2010, Zhang et al., 2010, Barber et al., 2009, Campbell et al., 2009, Flaherty et al., 2009, Genevet et al., 2009, Giagtzoglou et al., 2009, Glavic et al., 2009, Grusche et al., 2009, Guha et al., 2009, Hamaratoglu et al., 2009, Johnson et al., 2009, Kim et al., 2009, Kumar et al., 2009, Langton et al., 2009, Laprise et al., 2009, Lee et al., 2009, Lin et al., 2009, Marcette et al., 2009, Martinez et al., 2009, Massaro et al., 2009, Massarwa et al., 2009, Masuda-Nakagawa et al., 2009, Merino et al., 2009, Mirouse et al., 2009, Nagaraj and Banerjee, 2009, Ninov et al., 2009, O'Keefe et al., 2009, Ogawa et al., 2009, Patel et al., 2009, Peng et al., 2009, Peng et al., 2009, Peng et al., 2009, Rajan et al., 2009, Rodahl et al., 2009, Roeth et al., 2009, Romani et al., 2009, Sahota et al., 2009, Sawyer et al., 2009, Tiwari and Roy, 2009, Wairkar et al., 2009, Warner and Longmore, 2009, Warner and Longmore, 2009, Widmann and Dahmann, 2009, Woolworth et al., 2009, Yan et al., 2009, Zhang et al., 2009, Albertson et al., 2008, Alves-Silva et al., 2008, Bachmann et al., 2008, Bachmann et al., 2008, Baena-Lopez et al., 2008, Banerjee et al., 2008, Bao et al., 2008, Bogdanik et al., 2008, Cao et al., 2008, Chen et al., 2008, Cobreros et al., 2008, Devaud et al., 2008, Eid et al., 2008, Emes et al., 2008, Homem and Peifer, 2008, Horne-Badovinac and Bilder, 2008, Larson et al., 2008, Lee et al., 2008, Ly et al., 2008, Miech et al., 2008, Morrison et al., 2008, Narasimha et al., 2008, O'Connor-Giles et al., 2008, Pielage et al., 2008, Pope and Harris, 2008, Seppa et al., 2008, Sokac and Wieschaus, 2008, Speicher et al., 2008, Vogler and Urban, 2008, Willecke et al., 2008, Yasugi et al., 2008, Yu et al., 2008, Anuradha et al., 2007, Bach et al., 2007, Besse et al., 2007, Beuchle et al., 2007, Chandraratna et al., 2007, Conder et al., 2007, Copeland et al., 2007, Corrigall et al., 2007, Egger et al., 2007, Gorfinkiel and Arias, 2007, Grzeschik et al., 2007, Haines et al., 2007, Harris and Peifer, 2007, Huntwork and Littleton, 2007, Koh et al., 2007, Kohsaka et al., 2007, Kolsch et al., 2007, Korolchuk et al., 2007, Lee et al., 2007, Link et al., 2007, Menut et al., 2007, Mitonaka et al., 2007, Nagaraj and Banerjee, 2007, Nishimura et al., 2007, O'Keefe et al., 2007, Ou et al., 2007, Pfleger et al., 2007, Polesello and Tapon, 2007, Rohrbough et al., 2007, Roy et al., 2007, Sasaki et al., 2007, Song et al., 2007, Stowers and Isacoff, 2007, Szafranski and Goode, 2007, Tian and Ten Hagen, 2007, Walthall et al., 2007, Wang and Riechmann, 2007, Wang et al., 2007, Wu et al., 2007, Zhang et al., 2007, Zhao et al., 2007, Auld et al., 2006, Bayraktar et al., 2006, Bennett and Harvey, 2006, Dudu, 2006, Dudu et al., 2006, Ferres-Marco et al., 2006, Hamaratoglu et al., 2006, Johnson et al., 2006, Kim et al., 2006, Lovegrove et al., 2006, Mahr and Aberle, 2006, McCartney et al., 2006, Meyer and Aberle, 2006, Mirkovic and Mlodzik, 2006, Muro et al., 2006, Nolo et al., 2006, Pielage et al., 2006, Poulton and Deng, 2006, Qian and Prehoda, 2006, Rusten et al., 2006, Schmid et al., 2006, Schneider et al., 2006, Schulte et al., 2006, Siddall et al., 2006, Siegrist and Doe, 2006, Simoes et al., 2006, Singh et al., 2006, Suzuki and Ohno, 2006, Thompson and Cohen, 2006, Wang et al., 2006, Wang et al., 2006, Willecke et al., 2006, Xu et al., 2006, Ahringer, 2005, Araujo et al., 2005, Großhans et al., 2005, Guerrero et al., 2005, Hall et al., 2005, Harris and Peifer, 2005, Jafar-Nejad et al., 2005, Langevin et al., 2005, Le Bivic, 2005, Marques, 2005, Masuda-Nakagawa et al., 2005, Moberg et al., 2005, Munoz-Descalzo et al., 2005, Pielage et al., 2005, Sanchez-Soriano and Prokop, 2005, Siegrist and Doe, 2005, Sommer et al., 2005, Vaccari et al., 2005, Verstreken et al., 2005, Wei et al., 2005, Wu et al., 2005, Xu et al., 2005, Albertson et al., 2004, Albin and Davis, 2004, Bardin et al., 2004, Bellaiche et al., 2004, Betschinger and Knoblich, 2004, Cho, 2004, Coyle et al., 2004, Harris and Peifer, 2004, Kato et al., 2004, Koh et al., 2004, Lim and Choi, 2004, Llimargas et al., 2004, Menon et al., 2004, Siegrist and Doe, 2004, Strickland and Burgess, 2004, Torban et al., 2004, van Roessel et al., 2004, Wu and Beitel, 2004, Wu et al., 2004, Wu et al., 2004, Anonymous, 2003, Bachmann et al., 2003, Bastock et al., 2003, Bilder, 2003, Deng et al., 2003, Goode and Szafranski, 2003, Hemphala et al., 2003, Henrique and Schweisguth, 2003, Horton and Ehlers, 2003, Lecuit, 2003, Lee et al., 2003, Lim and Choi, 2003, Müller and Bossinger, 2003, Nelson, 2003, Rolls et al., 2003, Schulte et al., 2003, Udan et al., 2003, Zhao et al., 2003, Aberle et al., 2002, Chern and Choi, 2002, Hebbar and Fernandes, 2002, Hering and Sheng, 2002, Hoover and Bryant, 2002, Kango-Singh et al., 2002, Knox and Brown, 2002, Knust and Bossinger, 2002, Lee et al., 2002, Roche et al., 2002, Verstreken et al., 2002, Bellaiche et al., 2001, Bilder, 2001, Braga and Harwood, 2001, Chase, 2001, Hong et al., 2001, Knust, 2001, Leventis et al., 2001, Mayer, 2001, Parnas et al., 2001, Zahraoui et al., 2001, Zelhof et al., 2001, Bienz and Clevers, 2000, Bryant and Huwe, 2000, Cho, 2000, Hoover and Bryant, 2000, Huwe et al., 2000, Zahraoui et al., 2000, Dimitratos et al., 1999, Martinez Arias et al., 1999, Noselli and Agnes, 1999, Radovic' et al., 1999, Yeaman et al., 1999, Anonymous, 1998, Anonymous, 1998, Broadie, 1998, Brosamle, 1998, Craven and Bredt, 1998, Tsunoda et al., 1998, Tepass, 1997, Woods et al., 1997, Woods et al., 1997, Anderson, 1996, Woods et al., 1996, Fanning et al., 1993)
anon-EST:Posey93
anon-WO03040301.258
anon-WO03040301.260
anon-WO03040301.268
dlg
(Parvy et al., 2019, Ray et al., 2019, de Vreede et al., 2018, Richardson and Portela, 2018, Setiawan et al., 2018, Manent et al., 2017, Resnik-Docampo et al., 2017, Rives-Quinto et al., 2017, Roubinet et al., 2017, Tamori and Deng, 2017, Wang et al., 2017, Yamamoto et al., 2017, Bergstralh et al., 2016, Bosveld et al., 2016, Andersen et al., 2015, Bunker et al., 2015, Denes et al., 2015, Feng and Martin, 2015, Figueroa-Clarevega and Bilder, 2015, Guillermin et al., 2015, Lincoln et al., 2015, Merino et al., 2015, Gibson et al., 2014, Meier et al., 2014, Parisi et al., 2014, Skwarek et al., 2014, Tipping and Perrimon, 2014, Bangi, 2013, Hombría and Serras, 2013, Jagut et al., 2013, Levayer and Moreno, 2013, Morais-de-Sá and Sunkel, 2013, Nakajima et al., 2013, Willoughby et al., 2013, Eddison et al., 2012, Garelli et al., 2012, Gistelinck et al., 2012, Izumi et al., 2012, Justiniano et al., 2012, Miyashita et al., 2012, Saini and Reichert, 2012, Zoller and Schulz, 2012, Brumby et al., 2011, Cho et al., 2011, Desai and Lnenicka, 2011, Donlea et al., 2011, Letizia et al., 2011, Li et al., 2011, Miles et al., 2011, Ohsawa et al., 2011, Pastor-Pareja and Xu, 2011, Shulman et al., 2011, Thum et al., 2011, Wee et al., 2011, Bachmann et al., 2010, Bachmann et al., 2010, Bahri et al., 2010, Buchon et al., 2010, Cabernard et al., 2010, Cordero et al., 2010, Fichelson et al., 2010, Franz and Riechmann, 2010, Garlena et al., 2010, Grzeschik et al., 2010, Kitajima et al., 2010, Laprise et al., 2010, Simone and DiNardo, 2010, Thomson and Johnson, 2010, Walther and Pichaud, 2010, Apidianakis et al., 2009, Courbard et al., 2009, Donlea et al., 2009, Jansen et al., 2009, Johnston et al., 2009, Kaplan et al., 2009, Katsuki et al., 2009, Kumar et al., 2009, Li et al., 2009, Mao and Freeman, 2009, Newman and Prehoda, 2009, Ni et al., 2009, Papagiannouli and Mechler, 2009, Albornoz et al., 2008, Chia et al., 2008, Denef et al., 2008, Fernandez-Minan et al., 2008, Mendoza-Topaz et al., 2008, Moyer and Jacobs, 2008, Ni et al., 2008, Pastor-Pareja et al., 2008, Pielage et al., 2008, Rodal et al., 2008, Zhao et al., 2008, Bao et al., 2007, Blankenship et al., 2007, Gorczyca et al., 2007, Guthridge et al., 2007, Hackney et al., 2007, Heckscher et al., 2007, Kohsaka et al., 2007, Mendoza et al., 2007, Tountas and Fortini, 2007, Zhang et al., 2007, D'Costa et al., 2006, Denef et al., 2006, Hall et al., 2006, Humbert et al., 2006, Igaki et al., 2006, Igaki et al., 2006, Jankovics and Brunner, 2006, Janody and Treisman, 2006, Laprise et al., 2006, Szafranski and Goode, 2006, Viquez et al., 2006, Wirtz-Peitz and Knoblich, 2006, Wodarz and Gonzalez, 2006, Zhao et al., 2006, Cho, 2005, Djiane et al., 2005, Emery et al., 2005, Goode et al., 2005, Goode et al., 2005, Grosskortenhaus et al., 2005, Richardson et al., 2005, Werz et al., 2005, Wiggin et al., 2005, Yang et al., 2005, Zhao et al., 2005, Bachmann et al., 2004, Bilder, 2004, Brumby et al., 2004, Dudu et al., 2004, Dunlop et al., 2004, Grifoni et al., 2004, Kuppers-Munther et al., 2004, Lecuit, 2004, Roegiers and Jan, 2004, Szafranski and Goode, 2004, Wei et al., 2004, Abdelilah-Seyfried et al., 2003, Albertson and Doe, 2003, Bilder et al., 2003, Cross et al., 2003, Dow et al., 2003, Drapeau et al., 2003, Gibson and Perrimon, 2003, Humbert et al., 2003, Johnson and Wodarz, 2003, Le Borgne and Schweisguth, 2003, Lecuit and Pilot, 2003, Marhold et al., 2003, Mendoza et al., 2003, Muller, 2003, Pagliarini and Xu, 2003, Papagiannouli et al., 2003, Radovic and Bryant, 2003, Tanentzapf and Tepass, 2003, Wodarz and Huttner, 2003, Adler, 2002, Caruana, 2002, Chia and Yang, 2002, Cross et al., 2002, Johnston and Gallant, 2002, Kaltschmidt et al., 2002, Karunanithi et al., 2002, Kaufmann et al., 2002, Leeds and Coyle-Thompson, 2002, Marhold et al., 2002, Mathew et al., 2002, Medina et al., 2002, Pennetta et al., 2002, Wedlich, 2002, Bellaiche et al., 2001, Bilder, 2001, Doe, 2001, Doe and Bowerman, 2001, Greaves, 2001, Hardie and Raghu, 2001, Karunanithi et al., 2001, Kuchinke et al., 2001, Luxenberg et al., 2001, Mathew et al., 2001, Ohshiro et al., 2001, Radovic et al., 2001, Ramon and Coyle-Thompson, 2001, Schaefer and Knoblich, 2001, Tanentzapf and Tepass, 2001, Tepass et al., 2001, Wodarz, 2001, Wu et al., 2001, Andrew et al., 2000, Bilder et al., 2000, Dobens and Raftery, 2000, Goode, 2000, Greaves, 2000, Littleton and Ganetzky, 2000, Muller, 2000, Ohshiro et al., 2000, Peifer, 2000, Peng et al., 2000, Radovic et al., 2000, Ramon et al., 2000, Sone et al., 2000, Thomas et al., 2000, Wodarz, 2000, Agnes and Noselli, 1999, Atwood et al., 1999, Bilder and Perrimon, 1999, Bilder et al., 1999, Greaves et al., 1999, Jesu et al., 1999, Kim and Huganir, 1999, Koh et al., 1999, McGee and Bredt, 1999, Prokop, 1999, Rohrbough et al., 1999, Torroja et al., 1999, Turenchalk et al., 1999, Biessmann and Walter, 1998, Craven and Bredt, 1998, Gundelfinger et al., 1998, Jesu et al., 1998, Jesu et al., 1998, Kondo, 1998, Noselli, 1998, Ward et al., 1998, Woodhouse et al., 1998, Woods et al., 1998, Brunner and O'Kane, 1997, Bryant, 1997, Dimitratos et al., 1997, Goode and Perrimon, 1997, Goode and Perrimon, 1997, Hough et al., 1997, Izaddoost et al., 1997, Kim, 1997, Littlejohn et al., 1997, Makino et al., 1997, Petersen et al., 1997, Ponting et al., 1997, Ruiz-Cathada et al., 1997, Sheng and Wyszynski, 1997, Thomas et al., 1997, Thomas et al., 1997, Trimmer and Rhodes, 1997, Woods et al., 1997, Zito et al., 1997, Budnik, 1996, Budnik et al., 1996, Fagotto and Gumbiner, 1996, Fanning and Anderson, 1996, Guan et al., 1996, Hough et al., 1996, Peifer, 1996, Woods et al., 1996, Budnik et al., 1995, Goode and Perrimon, 1995, Kim, 1995, Kirkpatrick and Peifer, 1995, Shieh and Niemeyer, 1995, Binari and Perrimon, 1994, Gateff, 1994, Mechler, 1994, Watson et al., 1994, Boedigheimer et al., 1993, Bryant, 1993, Bryant et al., 1993, Garner et al., 1993, Peifer et al., 1993, Sehnal and Bryant, 1993, Skaer, 1993, Woods and Bryant, 1993, Woods and Bryant, 1993, Zitnan et al., 1993, Koonin et al., 1992, Woods and Bryant, 1992, Woods and Bryant, 1991, Bryant and Schmidt, 1990)
dlg1
(Birnbaum et al., 2019, Deshpande et al., 2019, Doktór et al., 2019, Kim et al., 2019, Donohoe et al., 2018, Lee et al., 2018, Hsu and Drummond-Barbosa, 2017, Katheder et al., 2017, Muzzopappa et al., 2017, Park et al., 2017, Aigouy and Le Bivic, 2016, Harris et al., 2016, Sarov et al., 2016, Schwartz et al., 2016, Wang et al., 2016, Zhimulev et al., 2016, Gene Disruption Project members, 2015-, Grotewiel and Bettinger, 2015, Haelterman, 2015.3.20, Nagarkar-Jaiswal et al., 2015, Ugrankar et al., 2015, Ashwal-Fluss et al., 2014, Haelterman et al., 2014, Kim and Choe, 2014, Liang et al., 2014, McDermott et al., 2014, Mhatre et al., 2014, Westholm et al., 2014, White-Grindley et al., 2014, Muerdter et al., 2013, Robinson and Atkinson, 2013, van Bon et al., 2013, Willemsen et al., 2013, Yamamoto et al., 2013-, Yin et al., 2013, Adamson and Lajeunesse, 2012, Aranjuez et al., 2012, Hazelett et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Lee et al., 2012, Legent et al., 2012, Maiya et al., 2012, Senthilan et al., 2012, Friedman et al., 2011, Goossens et al., 2011, Jungreis et al., 2011, Ribeiro et al., 2011, Kim and Marqués, 2010, Knowles-Barley et al., 2010, Popodi et al., 2010-, Venken et al., 2010, Dworkin et al., 2009, Ni et al., 2009, Bakal et al., 2008, Chen et al., 2008, Ni et al., 2008, Buszczak et al., 2007, Dietzl et al., 2007, Junion et al., 2007, Lecuyer et al., 2007, Quinones-Coello, 2007, Tyler and Baker, 2007, Armstrong et al., 2006, Wijnen et al., 2006, Rasse et al., 2005, Dow et al., 2003)
l(1)G19
l(1)d.lg.-1
l(1)l.pr.-2
Name Synonyms
Disc-Large
Discs large
(Baker, 2017, Moreira and Morais-de-Sá, 2016, Ng et al., 2016, Amoyel and Bach, 2014, Liang et al., 2014, Machamer et al., 2014, Wang et al., 2014, Bergstralh et al., 2013, Bräcker et al., 2013, Castellanos et al., 2013, Das et al., 2013, Hombría and Sotillos, 2013, Sotillos et al., 2013, Tögel et al., 2013, Woodfield et al., 2013, Coffee et al., 2012, Etchegaray et al., 2012, Kelsom and Lu, 2012, Miller et al., 2012, Moraru et al., 2012, Mukherjee et al., 2012, Panz et al., 2012, Smith et al., 2012, Verghese et al., 2012, Wang et al., 2012, Zhou and Hong, 2012, Ayyub, 2011, Gilbert et al., 2011, Park et al., 2011, Pastor-Pareja and Xu, 2011, Syed et al., 2011, Szul et al., 2011, Thum et al., 2011, Wang et al., 2011, Xu et al., 2011, Bahri et al., 2010, Buchon et al., 2010, Chen et al., 2010, Choi et al., 2010, David et al., 2010, Forster et al., 2010, Franz and Riechmann, 2010, Grzeschik et al., 2010, Hamel et al., 2010, Kim et al., 2010, Krahn et al., 2010, Lee and Wu, 2010, Masuda-Nakagawa et al., 2010, Maurel-Zaffran et al., 2010, Maynard et al., 2010, Milton et al., 2010, Murthy et al., 2010, Nelson et al., 2010, Padash-Barmchi et al., 2010, Robinson et al., 2010, Rohrbough and Broadie, 2010, Simone and DiNardo, 2010, Singh et al., 2010, Tamori et al., 2010, Tsurudome et al., 2010, Warner et al., 2010, Guha et al., 2009, Hamaratoglu et al., 2009, Kaplan et al., 2009, Kim et al., 2009, Langton et al., 2009, Laprise et al., 2009, Massarwa et al., 2009, O'Keefe et al., 2009, Patel et al., 2009, Ribaya et al., 2009, Sahota et al., 2009, von Trotha et al., 2009, Warner and Longmore, 2009, Warner and Longmore, 2009, Bachmann et al., 2008, Bao et al., 2008, Kolodziejczyk et al., 2008, Ratnaparkhi et al., 2008, Seppa et al., 2008, Ash et al., 2007, Blankenship et al., 2007, Chandraratna et al., 2007, Hackney et al., 2007, Huntwork and Littleton, 2007, Kondo et al., 2007, Krieser et al., 2007, Polesello and Tapon, 2007, Sasaki et al., 2007, Stowers and Isacoff, 2007, Bennett and Harvey, 2006, Kim et al., 2006, Muro et al., 2006, Poulton and Deng, 2006, Schulte et al., 2006, Suzuki and Ohno, 2006, Sanchez-Soriano and Prokop, 2005, Sommer et al., 2005, Wu et al., 2005, Harris and Peifer, 2004, Hipfner et al., 2004, Lecuit, 2004, Chan et al., 2003, Schneeberger and Raabe, 2003, Gibson and Schubiger, 2001, Martinez Arias et al., 1999)
discslarge
lethal(1)benign wing imaginal disc neoplasm
lethal(1)discs large
lethal(2)discs large
Secondary FlyBase IDs
  • FBgn0010108
  • FBgn0027239
  • FBgn0027662
  • FBgn0028321
  • FBgn0029052
  • FBgn0030295
  • FBgn0066811
  • FBgn0066812
  • FBgn0066813
Datasets (0)
Study focus (0)
Experimental Role
Project
Project Type
Title
References (1,277)