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Gene Dmel\dlg1

General Information
Symbol	Dmel\dlg1	Species	D. melanogaster
Name	discs large 1	Annotation symbol	CG1725
Feature type	protein_coding_gene	FlyBase ID	FBgn0001624
Gene Model Status	Current	Stock availability	32 publicly available
Also Known As	dlg, DlgA, l(1)d.lg-1, Dlg-A, misb, dlg-1, l(1)dlg, l(1)dlg-1, l(1)discs large, l(1)bwn
Genomic Location
Chromosome (arm)	X	Recombination map	1-34.8
Cytogenetic map	10B6-10B10	Sequence location	X:11,263,670..11,303,320 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene discs large 1 is referred to in FlyBase by the symbol Dmel\dlg1 (CG1725, FBgn0001624). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence for 16 unique biological process terms, many of which group under: anatomical structure development; localization; cellular component organization or biogenesis; macromolecule localization; mating; protein localization; morphogenesis of follicular epithelium; behavioral interaction between organisms; multicellular organismal reproductive process; synaptic transmission; locomotory behavior; establishment or maintenance of polarity of follicular epithelium; locomotion. 99 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; nervous system; organ system; multi-cell-component structure; adult segment; presumptive embryonic/larval nervous system; imaginal precursor; female germline cyst; plasma membrane part; cuticle. It has 17 annotated transcripts and 17 annotated polypeptides. Protein features are: Guanylate kinase; Guanylate kinase, conserved site; Guanylate kinase/L-type calcium channel; L27; L27-1; PDZ/DHR/GLGF; Src homology-3 domain; Variant SH3. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, during late pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression in all larval and adult organs/tissues ranges from low to undetected. Expression at high levels in the following post-embryonic organs or tissues: adult eye. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult hindgut, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland, larval/adult carcass. Gene sequence location is X:11263670..11303320.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	dlg1: discs large Late larval lethal; prolonged larval stages with bloated larvae attempting pupariation around day 15; some cuticular tanning, but no adult cuticular structures formed. During early larval development, the imaginal discs are smaller than those of normal larvae of the same age and are misshapen, but as the larvae continue to survive after the normal pupariation time, the discs continue to grow. They become large, amorphous, and solid, containing three times the normal numbers of cells at ten days of age; they also experience substantial cell death. By eleven days, wing and haltere discs may fuse; also first and second leg discs fuse with ventral ganglion of the CNS; great enlargement of optic lobes of brain also takes place. Discs, but not brains, transplanted into adults grow rapidly displaying invasive growth; they do not differentiate when transplanted into larvae for metamorphosis. Homozygous tissues do not survive, nor do gynandromorphs (one with male abdominal tissue vs. 66 expected). It is possible to produce homozygous germ-line clones (Perrimon). dlg1 embryos generated from such clones display defects in morphogenesis and neurogenesis; most tissues are defective; partial rescue achieved by a paternal dlg1+ contribution, in the form of either a normal X or a v+Y. dlg12 Homozygotes fail to survive when raised at 25; when raised at 18 however, 37% survival attained; hemizygous females show 65-70% survival at 18, but are also lethal at 25. Survival at 18 nearly complete in heterozygotes with dlg15 and dlg118, and survival at 25 is 4% and 95% respectively. Embryos produced by matings between surviving dlg12 flies raised at 18 show but 4% hatchability at 18, and such crosses are completely sterile at 25; however in crosses of homozygous dlg1+2 females to dlg1+ males, rescue of heterozygous daughters nearly complete at either 18 or 25 and is somewhat reduced at 29. Abnormal embryos produced by dlg12 females show failure of dorsal closure, and head involution. The maternal effect of dlg1 is germ-line specific, since embryos produced by homozygous clones in heterozygous mothers are indistinguishable from those produced by homozygous mothers (Perrimon, 1988, Dev. Biol. 127: 392-407).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features BKN51211 BKN51305 BKN50030 HFA20324 HFA18896 BKN41756 BKN41425 HFA18895 HFA19767 BKN42737 BKN51190 BKN51039 BKN50834 Controlled Vocabulary Terms perinuclear region of cytoplasm References Khuong et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(40): 17379--17384 Willecke et al., 2011, Oncogene 30(39): 4067--4074 Albornoz et al., 2008, Gene Expr. Patterns 8(6): 443--451 Gilbert et al., 2011, Dev. Cell 20(5): 700--712 Fan et al., 2010, Cell Death Differ. 17(6): 912--921 Cabernard et al., 2010, Nature 467(7311): 91--94 Ayyub, 2011, J. Genet. 90(2): 239--249 Peng et al., 2009, Biochem. Biophys. Res. Commun. 382(1): Raghu and Borst, 2011, PLoS ONE 6(5): e19472 Oshima and Fehon, 2011, J. Cell Sci. 124(16): 2861--2871 Ball et al., 2010, Neuron 66(4): 536--549 Rohrbough and Broadie, 2010, Development 137(20): 3523--3533 Rossetto et al., 2011, Hum. Mol. Genet. 20(21): 4248--4257
FB2011_10	References Knowles-Barley, 2011.8.24, BrainTrap expression curation. Georgiou and Baum, 2010, J. Cell Sci. 123(7): 1089--1098 Chen et al., 2008, PLoS Comput. Biol. 4(2): e1000026
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 10B6-10B10   Limits computationally determined from genome sequence between P{EP}CG11756EP1610 and P{EP}CG32666EP1452
Experimentally Determined Cytological Location
Cytogenetic map Notes References 10B14-10B17   (determined by in situ hybridisation) 10B8--11 (determined by in situ hybridisation)   (Peter et al., 2002) 10B8-10B11   (determined by in situ hybridisation)   (Schaefer et al., 1999.12.14) 10B8-10B11   (determined by in situ hybridisation)   (Schaefer et al., 1999.8.12) 10B14-10B17   (determined by in situ hybridisation)   (Schaefer et al., 1999.6.15) 10B8-10B11   (determined by in situ hybridisation)   (Woods and Bryant, 1989)
Experimentally Determined Recombination Data
Location	1-34.8   1-36.2 (Kiss et al., 1978) 1-34.82 (Geer et al., 1983, Perrimon and Mahowald, 1986, Binari and Perrimon, 1994)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\dlg1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.40 Gene model includes transcripts encoding non-overlapping portions of the full CDS.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) dlg1-RA FBtr0073486  NM_167282   4864   968 dlg1-RB FBtr0073488  NM_206683   5324   970 dlg1-RC FBtr0073483  NM_167280   2582   208 dlg1-RD FBtr0073485  NM_078565   4822   960 dlg1-RE FBtr0073487  NM_206684   4707   960 dlg1-RF FBtr0073484  NM_167281   2554   816 dlg1-RG FBtr0073489  NM_206682   4867   975 dlg1-RH FBtr0073490  NM_206681   5147   911 dlg1-RI FBtr0073491  NM_206680   2142   208 dlg1-RJ FBtr0073492  NM_206679   2130   208 dlg1-RK FBtr0112812  NM_001103485   6065   911 dlg1-RL FBtr0112813  NM_001103486   6788   946 dlg1-RM FBtr0301288  NM_001169247   3196   1030 dlg1-RN FBtr0301289  NM_001169248   4840   960 dlg1-RO FBtr0302114  NM_001169249   2361   206 dlg1-RP FBtr0308088     4841   983 dlg1-RQ FBtr0308089     5336   975
Additional Transcript Data & Comments
Reported size (kB)	5.1 (longest cDNA) (Woods and Bryant, 1991)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein dlg1-PA   FBpp0073342   103.2   968   8.49     NP_727520   AAF48038 dlg1-PB   FBpp0089351   106.7   970   6.75     NP_996406   AAS65308 dlg1-PC   FBpp0073339   24.4   208   10.43     NP_727518   AAF48037 dlg1-PD   FBpp0073341   102.4   960   7.87     NP_511120   AAF48039 dlg1-PE   FBpp0089350   102.4   960   7.87     NP_996407   AAS65313 dlg1-PF   FBpp0073340   88.7   816   4.49     NP_727519   AAN09630 dlg1-PG   FBpp0089352   104.0   975   7.15     NP_996405   AAS65312 dlg1-PH   FBpp0089353   100.2   911   6.95     NP_996404   AAS65309 dlg1-PI   FBpp0089348   24.4   208   10.43     NP_996403   AAS65310 dlg1-PJ   FBpp0089349   24.4   208   10.43     NP_996402   AAS65311 dlg1-PK   FBpp0111724   100.5   911   8.77     NP_001096955   ABW09394 dlg1-PL   FBpp0111725   104.3   946   6.61     NP_001096956   ABW09395 dlg1-PM   FBpp0290503   112.5   1030   4.80     NP_001162718   ACZ95253 dlg1-PN   FBpp0290504   102.4   960   7.87     NP_001162719   ACZ95254 dlg1-PO   FBpp0291324   24.2   206   10.43     NP_001162720   ACZ95255 dlg1-PP   FBpp0300431   104.9   983   7.56       dlg1-PQ   FBpp0300432   104.0   975   7.15
Additional Polypeptide Data & Comments
Reported size (kDa)	960 (aa); 102 (kD) (Woods and Bryant, 1991)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Src homology-3 domain (IPR001452) PDZ/DHR/GLGF (IPR001478) L27 (IPR004172) Guanylate kinase (IPR008144) Guanylate kinase/L-type calcium channel (IPR008145) L27-1 (IPR015143) Guanylate kinase, conserved site (IPR020590) Variant SH3 (IPR011511)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202290   AA203039   AA263928   AA391639   AA735698   AA979335   AE014298 AAF48037   AE014298 AAF48038   AE014298 AAF48039   AE014298 AAN09630   AE014298 AAS65308   AE014298 AAS65309   AE014298 AAS65310   AE014298 AAS65311   AE014298 AAS65312   AE014298 AAS65313   AE014298 ABW09394   AE014298 ABW09395   AE014298 ACZ95253   AE014298 ACZ95254   AE014298 ACZ95255   AF171794   AI062058   AI292923   AI294433   AI387558   AI403687   AI514083   AI515310   AI520395   AI531210   AJ426861   AJ426862   AW940096   AW942147   AX777404   AX777406   AX777414   AY059433 AAL13339   AY069408 AAL39553   AY075410 AAL68235   AY332243 AAQ01226   BI163243   BI163834   BI165651   BI216148   BI227551   BI230304   BI234656   BI234828   BI239863   BI370960   BI375508   BI485743   BI577343   BI592481   BI609373   BI610842   BI614082   BI621421   BI634846   BP545929   BP551140   BP551393   BP551804   BP551805   BP556112   BP558843   BT024959   BT081965   BT099726   BT125867   CK131675   CK131681   CO178434   CO178655   CO185503   CO185838   CO185972   CO186979   CO187244   CO188052   CO189783   CO193640   CO262580   CO263558   CO265413   CO266055   CO266220   CO270384   CO271651   CO273740   CO275716   CO275784   CO278884   CO278929   CO284118   CO285321   CO286138   CO286885   CO287266   CO288677   CO289671   CO289715   CO289767   CO290211   CO290659   CO291533   CO292922   CO293873   CO296114   CO298010   CO300577   CO301686   CO303570   CO304409   CO305585   CO313655   CO313689   CO315204   CO320993   CO321260   CO323009   CO329148   CO331703   CO331883   CO337241   CO338328   CO340501   CO343016   CO343865   CO344210   CO344718   CZ476394   CZ477415   CZ481376   CZ481377   CZ490653   DQ066624 AAY83340   EC058424   EC058687   EC058845   EC058867   EC060543   EC063537   EC063674   EC063746   EC064261   EC066669   EC067317   EC070180   EC070260   EC072366   EC073822   EC075539   EC076809   EC077373   EC079192   EC080323   EC080606   EC081664   EC084181   EC084423   EC085132   EC085720   EC194490   EC194681   EC197629   EC199027   EC200217   EC201979   EC202778   EC203719   EC206525   EC206895   EC207923   EC207953   EC208385   EC209882   EC213667   EC214336   EC215669   EC221547   EC224378   EC228125   EC229071   EC229454   EC230254   EC230859   EC230975   EC231400   EC231980   EC235434   EC237221   EC237683   EC239521   EC240729   EC243916   EC244082   EC248552   EC250347   EC252946   EC254981   EC255137   EC256122   EC259390   EC260672   EC266091   EC268002   EL875197   EV580913   EV583793   EV587112   EV587277   EV597258   EV599827   GH952717   GH954018   GH959979   GH960259   GH962809   GH963088   GH965846   GH966579   GH967688   GH979293   GH979441   GH979974   GH980305   GH983426   GH984129   GH985016   M73529 AAA28468
UniProtKB/Swiss-Prot	P31007
UniProtKB/TrEMBL	Q4PLW2 C1C536 E1JJH6 E1JJH5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 5   epithelial cell   • lateral plasma membrane (Lecuyer et al., 2007) epithelium   • lateral plasma membrane (Lecuyer et al., 2007)
Additional Descriptive Data
	dlg1 transcripts are expressed throughout development. (Woods and Bryant, 1991)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   epidermis   (Woods and Bryant, 1991) embryonic/larval digestive system   (Woods and Bryant, 1991) peripheral nervous system   (Woods and Bryant, 1991) embryonic brain   (Woods and Bryant, 1991) embryonic/larval central nervous system | restricted   (Mendoza-Topaz et al., 2008) embryonic somatic muscle | subset   (Mendoza-Topaz et al., 2008) ventral nerve cord | restricted   (Mendoza-Topaz et al., 2008) embryonic stage 13   embryonic leading edge cell   • septate junction (Arquier et al., 2001) embryonic stage 16   epithelial cell of embryonic/larval salivary gland   • septate junction (Paul et al., 2003) embryonic/larval tracheocyte   • septate junction (Paul et al., 2003) epidermal cell   • septate junction (Paul et al., 2003) larval stage   embryonic/larval salivary gland   (Woods and Bryant, 1991) ventral nerve cord   (Woods and Bryant, 1991) embryonic/larval proventriculus   (Woods and Bryant, 1991) embryonic/larval brain   (Woods and Bryant, 1991) optic lobe   (Woods and Bryant, 1991) imaginal disc   (Woods and Bryant, 1991) third instar larval stage   wing disc   • septate junction (Arquier et al., 2001) embryonic/larval neuromuscular junction   • postsynaptic membrane (Zelhof et al., 2001) embryonic/larval neuromuscular junction | subset   (Mendoza-Topaz et al., 2008) embryonic/larval neuromuscular junction of glutamatergic neuron | subset   (Mendoza-Topaz et al., 2008) adult stage | male   ejaculatory bulb   (Woods and Bryant, 1991) male accessory gland   (Woods and Bryant, 1991) adult stage   adult neuromuscular junction   (Beramendi et al., 2007) photoreceptor cell R1 -- photoreceptor cell R6   (Kolodziejczyk et al., 2008) lamina neuropil | faint & restricted   (Hamanaka and Meinertzhagen, 2010) medulla neuropil | faint & restricted   (Hamanaka and Meinertzhagen, 2010) photoreceptor cell R1 | restricted   (Hamanaka and Meinertzhagen, 2010) photoreceptor cell R2 | restricted   (Hamanaka and Meinertzhagen, 2010) photoreceptor cell R3 | restricted   (Hamanaka and Meinertzhagen, 2010) photoreceptor cell R4 | restricted   (Hamanaka and Meinertzhagen, 2010) photoreceptor cell R5 | restricted   (Hamanaka and Meinertzhagen, 2010) photoreceptor cell R6 | restricted   (Hamanaka and Meinertzhagen, 2010) adult brain | restricted   (Mendoza-Topaz et al., 2008) lamina | restricted   (Mendoza-Topaz et al., 2008) adult mushroom body | restricted   (Mendoza-Topaz et al., 2008) adult antennal lobe | restricted   (Mendoza-Topaz et al., 2008) adult stage & oogenesis   nurse cell   (Woods and Bryant, 1991) follicle cell   (Woods and Bryant, 1991) oogenesis & adult stage | female   oogonial cell   (Woods and Bryant, 1991) germline cell   (Szafranski and Goode, 2004) adult stage | female & oogenesis   follicle cell   (Szafranski and Goode, 2004) oogenesis stage S7 -- S9 & adult stage | female   polar follicle cell   • leading edge membrane (Szafranski and Goode, 2004) border follicle cell   (Szafranski and Goode, 2004) spermatogenesis & adult stage   primary gonial cell   (Woods and Bryant, 1991) testis   (Woods and Bryant, 1991) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
	dlg1 protein is found mainly in epithelia, where it is localized at the apical part of the lateral cell membrane. (Woods and Bryant, 1991) dlg1 is expressed in central brain neuropils. Lamina cross-sections exhibited a bright ring of R1-R6 terminals that label with dlg1. Using immunoelectron microscopy, dlg1 is often seen close to the heads of the capitate projections (invaginations from surrounding epithelial glial and specialised organelles for the endocytosis of vesicle membrane), but not the stalks. (Hamanaka and Meinertzhagen, 2010) Expression of dlg1 is observed in the neuromuscular junction of wildtype fly at 3, 15, 30 and 60 days post-eclosion. (Beramendi et al., 2007)
Marker for
	septate junction neuromuscular junction postsynaptic membrane
Subcellular Localization
CV Term	septate junction (Woods and Bryant, 1991)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0001624    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0001624 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, during late pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0001624 expression level Developmental Stage   Expression Level embryo 00-02hr    1687 embryo 02-04hr    3145 embryo 04-06hr    3190 embryo 06-08hr    2434 embryo 08-10hr    2296 embryo 10-12hr    1605 embryo 12-14hr    1878 embryo 14-16hr    2105 embryo 16-18hr    2557 embryo 18-20hr    2374 embryo 20-22hr    2405 embryo 22-24hr    2288 larva L1    1630 larva L2    1124 larva L3 12hr old    1145 larva L3 puffstage 1-2    553 larva L3 puffstage 3-6    1005 larva L3 puffstage 7-9    1064 white prepupae new    1074 white prepupae 12hr    957 white prepupae 24hr    1323 pupae 2d postWPP    1627 pupae 3d postWPP    2783 pupae 4d postWPP    3289 adult male 01day    1822 adult male 05day    1479 adult male 30day    1418 adult female 01day    1912 adult female 05day    1320 adult female 30day    1357 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1687) embryo 02-04hr  (3145) embryo 04-06hr  (3190) embryo 06-08hr  (2434) embryo 08-10hr  (2296) embryo 10-12hr  (1605) embryo 12-14hr  (1878) embryo 14-16hr  (2105) embryo 16-18hr  (2557) embryo 18-20hr  (2374) embryo 20-22hr  (2405) embryo 22-24hr  (2288) larva L1  (1630) larva L2  (1124) larva L3 12hr old  (1145) larva L3 puffstage 1-2  (553) larva L3 puffstage 3-6  (1005) larva L3 puffstage 7-9  (1064) white prepupae new  (1074) white prepupae 12hr  (957) white prepupae 24hr  (1323) pupae 2d postWPP  (1627) pupae 3d postWPP  (2783) pupae 4d postWPP  (3289) adult male 01day  (1822) adult male 05day  (1479) adult male 30day  (1418) adult female 01day  (1912) adult female 05day  (1320) adult female 30day  (1357) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (1687) embryo 02-04hr  (3145) embryo 04-06hr  (3190) embryo 06-08hr  (2434) embryo 08-10hr  (2296) embryo 10-12hr  (1605) embryo 12-14hr  (1878) embryo 14-16hr  (2105) embryo 16-18hr  (2557) embryo 18-20hr  (2374) embryo 20-22hr  (2405) embryo 22-24hr  (2288) larva L1  (1630) larva L2    1124 larva L3 12hr old    1145 larva L3 puffstage 1-2    553 larva L3 puffstage 3-6    1005 larva L3 puffstage 7-9    1064 white prepupae new    1074 white prepupae 12hr    957 white prepupae 24hr    1323 pupae 2d postWPP  (1627) pupae 3d postWPP  (2783) pupae 4d postWPP  (3289) adult male 01day  (1822) adult male 05day  1479 adult male 30day  1418 adult female 01day  (1912) adult female 05day    1320 adult female 30day    1357 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1687 embryo 02-04hr    3145 embryo 04-06hr    3190 embryo 06-08hr    2434 embryo 08-10hr    2296 embryo 10-12hr    1605 embryo 12-14hr    1878 embryo 14-16hr    2105 embryo 16-18hr    2557 embryo 18-20hr    2374 embryo 20-22hr    2405 embryo 22-24hr    2288 larva L1    1630 larva L2    1124 larva L3 12hr old    1145 larva L3 puffstage 1-2    553 larva L3 puffstage 3-6    1005 larva L3 puffstage 7-9    1064 white prepupae new    1074 white prepupae 12hr    957 white prepupae 24hr    1323 pupae 2d postWPP    1627 pupae 3d postWPP    2783 pupae 4d postWPP    3289 adult male 01day    1822 adult male 05day    1479 adult male 30day    1418 adult female 01day    1912 adult female 05day    1320 adult female 30day    1357 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1687 embryo 02-04hr    3145 embryo 04-06hr    3190 embryo 06-08hr    2434 embryo 08-10hr    2296 embryo 10-12hr    1605 embryo 12-14hr    1878 embryo 14-16hr    2105 embryo 16-18hr    2557 embryo 18-20hr    2374 embryo 20-22hr    2405 embryo 22-24hr    2288 larva L1    1630 larva L2    1124 larva L3 12hr old    1145 larva L3 puffstage 1-2    553 larva L3 puffstage 3-6    1005 larva L3 puffstage 7-9    1064 white prepupae new    1074 white prepupae 12hr    957 white prepupae 24hr    1323 pupae 2d postWPP    1627 pupae 3d postWPP    2783 pupae 4d postWPP    3289 adult male 01day    1822 adult male 05day    1479 adult male 30day    1418 adult female 01day    1912 adult female 05day    1320 adult female 30day    1357 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0001624 expression level Developmental Stage   Expression Level embryo 00-02hr    1687 embryo 02-04hr    3145 embryo 04-06hr    3190 embryo 06-08hr    2434 embryo 08-10hr    2296 embryo 10-12hr    1605 embryo 12-14hr    1878 embryo 14-16hr    2105 embryo 16-18hr    2557 embryo 18-20hr    2374 embryo 20-22hr    2405 embryo 22-24hr    2288 larva L1    1630 larva L2    1124 larva L3 12hr old    1145 larva L3 puffstage 1-2    553 larva L3 puffstage 3-6    1005 larva L3 puffstage 7-9    1064 white prepupae new    1074 white prepupae 12hr    957 white prepupae 24hr    1323 pupae 2d postWPP    1627 pupae 3d postWPP    2783 pupae 4d postWPP    3289 adult male 01day    1822 adult male 05day    1479 adult male 30day    1418 adult female 01day    1912 adult female 05day    1320 adult female 30day    1357 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (1687) embryo 02-04hr  (3145) embryo 04-06hr  (3190) embryo 06-08hr  (2434) embryo 08-10hr  (2296) embryo 10-12hr  (1605) embryo 12-14hr  (1878) embryo 14-16hr  (2105) embryo 16-18hr  (2557) embryo 18-20hr  (2374) embryo 20-22hr  (2405) embryo 22-24hr  (2288) larva L1  (1630) larva L2  (1124) larva L3 12hr old  (1145) larva L3 puffstage 1-2  (553) larva L3 puffstage 3-6  (1005) larva L3 puffstage 7-9  (1064) white prepupae new  (1074) white prepupae 12hr  (957) white prepupae 24hr  (1323) pupae 2d postWPP  (1627) pupae 3d postWPP  (2783) pupae 4d postWPP  (3289) adult male 01day  (1822) adult male 05day  (1479) adult male 30day  (1418) adult female 01day  (1912) adult female 05day  (1320) adult female 30day  (1357) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  1687 embryo 02-04hr  (3145) embryo 04-06hr  (3190) embryo 06-08hr  2434 embryo 08-10hr  2296 embryo 10-12hr  1605 embryo 12-14hr  1878 embryo 14-16hr  2105 embryo 16-18hr  (2557) embryo 18-20hr  2374 embryo 20-22hr  2405 embryo 22-24hr  2288 larva L1  1630 larva L2    1124 larva L3 12hr old    1145 larva L3 puffstage 1-2    553 larva L3 puffstage 3-6    1005 larva L3 puffstage 7-9    1064 white prepupae new    1074 white prepupae 12hr    957 white prepupae 24hr    1323 pupae 2d postWPP  1627 pupae 3d postWPP  (2783) pupae 4d postWPP  (3289) adult male 01day  1822 adult male 05day  1479 adult male 30day  1418 adult female 01day  1912 adult female 05day    1320 adult female 30day    1357 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1687 embryo 02-04hr    3145 embryo 04-06hr    3190 embryo 06-08hr    2434 embryo 08-10hr    2296 embryo 10-12hr    1605 embryo 12-14hr    1878 embryo 14-16hr    2105 embryo 16-18hr    2557 embryo 18-20hr    2374 embryo 20-22hr    2405 embryo 22-24hr    2288 larva L1    1630 larva L2    1124 larva L3 12hr old    1145 larva L3 puffstage 1-2    553 larva L3 puffstage 3-6    1005 larva L3 puffstage 7-9    1064 white prepupae new    1074 white prepupae 12hr    957 white prepupae 24hr    1323 pupae 2d postWPP    1627 pupae 3d postWPP    2783 pupae 4d postWPP    3289 adult male 01day    1822 adult male 05day    1479 adult male 30day    1418 adult female 01day    1912 adult female 05day    1320 adult female 30day    1357 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1687 embryo 02-04hr    3145 embryo 04-06hr    3190 embryo 06-08hr    2434 embryo 08-10hr    2296 embryo 10-12hr    1605 embryo 12-14hr    1878 embryo 14-16hr    2105 embryo 16-18hr    2557 embryo 18-20hr    2374 embryo 20-22hr    2405 embryo 22-24hr    2288 larva L1    1630 larva L2    1124 larva L3 12hr old    1145 larva L3 puffstage 1-2    553 larva L3 puffstage 3-6    1005 larva L3 puffstage 7-9    1064 white prepupae new    1074 white prepupae 12hr    957 white prepupae 24hr    1323 pupae 2d postWPP    1627 pupae 3d postWPP    2783 pupae 4d postWPP    3289 adult male 01day    1822 adult male 05day    1479 adult male 30day    1418 adult female 01day    1912 adult female 05day    1320 adult female 30day    1357 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0001624    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0001624 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression in all larval and adult organs/tissues ranges from low to undetected. Expression at high levels in the following post-embryonic organs or tissues: adult eye. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult hindgut, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult ovary, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_09
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001624 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1725-RD;CG1725-RC;CG1725-RF;CG1725-RF
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal dlg11 dlg15 dlg16 dlg19 dlg115 dlg116 dlg117 lethal, with Scer\GAL4Mef2.PR dlg1GD4689 lethal, with Scer\GAL4pnr-MD237 dlg1GD4689 lethal | embryonic stage | maternal effect dlg1sw lethal | heat sensitive dlg12 lethal | larval stage dlg11 dlg1G0276 lethal | larval stage | recessive dlg17 dlg112 dlg114 dlg115 lethal | pharate adult stage | recessive dlg118 lethal | polyphasic | recessive dlg17 lethal | prepupal stage dlg1G0276 dlg1G0456 lethal | pupal stage dlg15 dlg18 dlg1G0342 dlg1G0456 lethal | pupal stage | recessive dlg15 dlg16 dlg18 dlg112 dlg114 dlg118 lethal | recessive dlg11 dlg14 dlg15 dlg16 dlg17 dlg19 dlg111 dlg112 dlg113 dlg114 dlg115 dlg118 dlg119 dlg1G0276 dlg1G0342 dlg1G0456 dlg1PG100 dlg1PL32 lethal | recessive | heat sensitive dlg12 lethal | third instar larval stage dlg1A40.2 semi-lethal, with Scer\GAL4elav.PLu dlg1GD4689 viable dlg1CC01936 dlg1S97-rev150 dlg1sw Other Phenotypes Allele cell polarity defective | somatic clone dlg114 courtship behavior defective | recessive dlg1S97-5 flight defective, with Scer\GAL4elav.PLu dlg1GD4689 flightless dlg17 hyperplasia dlg114 hyperplasia | recessive dlg16 dlg17 locomotor behavior defective, with Scer\GAL4elav.PLu dlg1GD4689 locomotor rhythm defective | adult stage | recessive dlg1S97-5 dlg1S97-138 mating defective | recessive dlg1S97-5 neuroanatomy defective dlg16 dlg17 dlg114 neuroanatomy defective, with Scer\GAL4BG487 dlg1Scer\UAS.cBa neuroanatomy defective | pupal stage | recessive dlg16 dlg112 neuroanatomy defective | recessive dlg16 dlg17 neuroanatomy defective | recessive | heat sensitive dlg12 neuroanatomy defective | third instar larval stage (with Df(1)N71) dlg114 neurophysiology defective dlg16 dlg17 dlg114 neurophysiology defective | larval stage | recessive dlg1A40.2 neurophysiology defective | third instar larval stage (with Df(1)N71) dlg114 phototaxis behavior defective | adult stage | recessive dlg1S97-5 dlg1S97-138 tumorigenic dlg17 tumorigenic | recessive dlg114 visible dlg1sw visible, with Scer\GAL4en-e16E dlg1JF01076 visible | larval stage dlg17 visible | recessive dlg1misb Phenotype manifest in Allele adherens junction dlg114 dlg1unspecified adherens junction | ectopic dlg114 antenna dlg118 axon dlg1S97N dlg1a.S97N border follicle cell dlg12 border follicle cell (with dlg12) dlg15 border follicle cell (with dlg15) dlg12 bouton dlg112 dlg16 dlg17 brain | third instar larval stage (with Df(1)N71) dlg114 egg chamber | somatic clone dlg114 embryo | germline clone dlg11 embryonic/first instar larval cuticle dlg114 embryonic/larval brain dlg17 dlg1G4 dlg1G5 dlg1G6 dlg1G7 dlg1G8 dlg1G9 dlg1A40.2 embryonic/larval brain | heat sensitive dlg12 embryonic/larval optic lobe dlg17 embryonic epidermis | dorsal | maternal effect dlg1sw embryonic epidermis | germline clone dlg114 embryonic neuroblast dlg114 epithelial cell | germline clone dlg114 external sensory organ precursor cell I dlg118 dlg1sw eye-antennal disc dlg114 follicle cell dlg1sw follicle cell | cell autonomous | somatic clone dlg114 follicle cell | germline clone dlg114 follicle cell | heat sensitive dlg12 follicle cell | somatic clone dlg114 germline cell | germline clone dlg114 imaginal disc dlg112 dlg114 dlg115 dlg16 dlg17 dlg18 imaginal disc & epithelial cell & plasma membrane | somatic clone dlg114 imaginal disc & epithelial cell & septate junction | somatic clone dlg114 imaginal disc & septate junction dlg114 imaginal disc | heat sensitive dlg12 imaginal disc | larval stage dlg1A40.2 imaginal disc | third instar larval stage (with Df(1)N71) dlg114 intermediate longitudinal fascicle dlg1S97N dlg1a.S97N interommatidial bristle dlg118 dlg1sw lateral longitudinal fascicle dlg1S97N dlg1a.S97N leg dlg118 macrochaeta dlg118 dlg1misb medial longitudinal fascicle dlg1S97N dlg1a.S97N mesothoracic leg disc | larval stage dlg17 neuroblast | embryonic stage | germline clone dlg114 neuromuscular junction dlg17 neuromuscular junction & bouton dlg17 neuromuscular junction & postsynaptic membrane dlg17 neuromuscular junction | larval stage dlg17 NMJ bouton dlg17 pleated septate junction dlg114 postsynaptic membrane dlg114 dlg12 dlg16 dlg17 postsynaptic membrane, with Scer\GAL4BG487 dlg1Scer\UAS.cBa postsynaptic membrane & neuromuscular junction | larval stage dlg17 prepupal cuticle dlg19 presumptive embryonic/larval central nervous system dlg1S97N dlg1a.S97N presumptive embryonic/larval nervous system | germline clone dlg114 presumptive embryonic/larval peripheral nervous system dlg1S97N dlg1a.S97N presynaptic membrane & neuromuscular junction | larval stage dlg17 dlg1A40.2 dlg1S97-138 prothoracic leg disc | larval stage dlg17 puparium dlg19 ring gland dlg18 septate junction dlg114 socket dlg1misb subsynaptic reticulum dlg17 subsynaptic reticulum, with Scer\GAL4BG487 dlg1Scer\UAS.cBa subsynaptic reticulum, with Scer\GAL4Mhc.PW dlg1WT.Scer\UAS.T:Avic\GFP supraesophageal commissural pioneer tract dlg1S97N dlg1a.S97N synapse | third instar larval stage (with Df(1)N71) dlg114 type I bouton & synaptic vesicle & third instar larva (with Df(1)N71) dlg114 ventral nerve cord dlg1S97N dlg1a.S97N ventral nerve cord | larval stage dlg17 wing, with Scer\GAL4en-e16E dlg1JF01076 wing disc dlg18 wing disc | larval stage dlg17
Classical Alleles ( 57 )
For All Classical Alleles Show
Allele of dlg1 Class Mutagen Stocks Known lesion dlg1G0276 P-element activity 2 -- dlg1G0342 P-element activity 2 -- dlg114 amorphic allele - genetic evidence, loss of function allele ethyl nitrosourea 1 Yes dlg118 hypomorphic allele - genetic evidence ethyl methanesulfonate 1 Yes dlg12 hypomorphic allele - genetic evidence X ray 1 Yes dlg15-HA-1959 1 -- dlg15 hypomorphic allele - genetic evidence ethyl methanesulfonate 1 -- dlg16 ethyl methanesulfonate 1 Yes dlg1CB-5424-3 1 -- dlg1d08753 P-element activity 1 -- dlg1d10747 P-element activity 1 -- dlg1e03622 piggyBac transposase 1 -- dlg1EY05003 1 -- dlg1f03974 1 -- dlg1f07937 piggyBac transposase 1 -- dlg1G0456 P-element activity 1 -- dlg1NP1102 1 -- dlg1NP4134 1 -- dlg1NP7225 1 -- dlg110 ethyl nitrosourea 0 -- dlg111 ethyl nitrosourea 0 -- dlg112 ethyl nitrosourea 0 Yes dlg113 ethyl nitrosourea 0 -- dlg115 loss of function allele X ray 0 -- dlg116 0 -- dlg117 0 -- dlg119 diepoxybutane 0 -- dlg11 X ray ethyl methanesulfonate 0 -- dlg13 X ray 0 -- dlg14 X ray 0 -- dlg17 loss of function allele, hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes dlg18 ethyl methanesulfonate 0 -- dlg19 ethyl methanesulfonate 0 -- dlg1A-51.1 P-element activity 0 Yes dlg1A40.2 Delta2-3 0 Yes dlg1b88 0 Yes dlg1CC01936 P-element activity 0 Yes dlg1CPTI000207 piggyBac transposase 0 Yes dlg1CPTI002569 piggyBac transposase 0 Yes dlg1CPTI002860 piggyBac transposase 0 Yes dlg1G4 ethyl methanesulfonate 0 -- dlg1G5 X ray 0 -- dlg1G6 X ray 0 -- dlg1G7 X ray 0 -- dlg1G8 X ray 0 -- dlg1G9 X ray 0 -- dlg1GG01705 0 -- dlg1misb 0 -- dlg1PG100 Delta2-3 0 -- dlg1PL32 Delta2-3 0 -- dlg1S97-138 Delta2-3 0 Yes dlg1S97-5 Delta2-3 0 Yes dlg1S97-flpV FLPase recombination 0 Yes dlg1S97-rev150 Delta2-3 0 Yes dlg1sw 0 Yes dlg1unspecified 0 -- dlg1w55 0 --
Alleles Carried on Transgenic Constructs ( 42 )
For All Alleles Carried on Transgenic Constructs Show
Allele of dlg1 Class Mutagen Stocks Known lesion dlg1GD4689 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes dlg1GL00188 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dlg1HMS00014 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dlg1HMS00024 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dlg1HMS00172 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dlg1HMS01521 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dlg1JF01076 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dlg1JF01077 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dlg1JF01365 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dlg1JF01694 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dlg1a.S97N in vitro construct - RNAi 0 Yes dlg1cQa in vitro construct 0 Yes dlg1dsRNA.cBa in vitro construct - RNAi 0 Yes dlg1HOOK.Scer\UAS.T:Zzzz\FLAG in vitro construct - deletion 0 Yes dlg1KK116285 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes dlg1PDZ2+HOOK.Scer\UAS.T:Zzzz\FLAG in vitro construct - deletion 0 Yes dlg1S48A.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes dlg1S48D.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes dlg1S97N.Scer\UAS.T:Avic\GFP-EGFP in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes dlg1S97N in vitro construct - RNAi 0 Yes dlg1SA.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes dlg1Scer\UAS.cBa in vitro construct - regulatory fusion 0 Yes dlg1Scer\UAS.T:Avic\GFP-YFP in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes dlg1Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes dlg1SD.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes dlg1WT.Scer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes dlg1WT.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes dlg1ΔC1:2.Scer\UAS.T:Zzzz\FLAG in vitro construct - deletion in vitro construct - regulatory fusion 0 Yes dlg1ΔE-F.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes dlg1ΔGUK.Scer\UAS.T:Zzzz\FLAG in vitro construct - deletion in vitro construct - regulatory fusion 0 Yes dlg1ΔHOOK.Scer\UAS.T:Zzzz\FLAG in vitro construct - deletion in vitro construct - regulatory fusion 0 Yes dlg1ΔI3.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes dlg1ΔN.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes dlg1ΔN2:3.Scer\UAS.T:Zzzz\FLAG in vitro construct - deletion in vitro construct - regulatory fusion 0 Yes dlg1ΔPDZ1.Scer\UAS.T:Zzzz\FLAG in vitro construct - deletion in vitro construct - regulatory fusion 0 Yes dlg1ΔPDZ1:2.Scer\UAS.T:Zzzz\FLAG in vitro construct - deletion in vitro construct - regulatory fusion 0 Yes dlg1ΔPDZ1:3.Scer\UAS.T:Zzzz\FLAG in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes dlg1ΔPDZ2.Scer\UAS.T:Zzzz\FLAG in vitro construct - deletion in vitro construct - regulatory fusion 0 Yes dlg1ΔPDZ2:3.Scer\UAS.T:Zzzz\FLAG in vitro construct - deletion 0 Yes dlg1ΔPDZ3.Scer\UAS.T:Zzzz\FLAG in vitro construct - deletion in vitro construct - regulatory fusion 0 Yes dlg1ΔSH3.Scer\UAS.T:Zzzz\FLAG in vitro construct - deletion in vitro construct - regulatory fusion 0 Yes dlg1Δt40.Scer\UAS.T:Zzzz\FLAG in vitro construct 0 Yes
Aneuploid Aberrations
Duplicated in	Dp(1;2)v+65b (Geer et al., 1983, Zhimulev et al., 1987) Dp(1;2)v+75d (Geer et al., 1983) Dp(1;3)DC238 (Popodi et al., 2010-) Dp(1;Y)dsh+y+ (Zhimulev et al., 1987) Dp(1;Y)v+y+ (Geer et al., 1983, Zhimulev et al., 1987, Woods and Bryant, 1989) Dp(1;Y)v+y+366 (Zhimulev et al., 1987)
Not disrupted in	Df(1)59D3 (Zhimulev et al., 1987) Df(1)203C10 (Zhimulev et al., 1987) Df(1)HC133 (Zhimulev et al., 1987) Df(1)m13 (Woods and Bryant, 1989, Caggese et al., 1994) Df(1)ras-P14 (Zhimulev et al., 1987) Df(1)ras-v17 (Zhimulev et al., 1987) Df(1)ras-v-P26 (Zhimulev et al., 1987) Df(1)sbr1 (Zhimulev et al., 1987) Df(1)sbr8 (Zhimulev et al., 1987) Df(1)sbr9 (Zhimulev et al., 1987) Df(1)sbr10 (Zhimulev et al., 1987) Df(1)v64f (Zhimulev et al., 1987) Df(1)v-B151 (Zhimulev et al., 1987) Df(1)v-L1 (Geer et al., 1983, Zhimulev et al., 1987) Df(1)v-L2 (Geer et al., 1983, Zhimulev et al., 1987) Df(1)v-L3 (Geer et al., 1983, Zhimulev et al., 1987) Df(1)v-L4 (Geer et al., 1983, Zhimulev et al., 1987) Df(1)v-L7 (Zhimulev et al., 1987) Df(1)v-L11 (Zhimulev et al., 1987) Df(1)v-L15 (Zhimulev et al., 1987) Df(1)v-M1 (Zhimulev et al., 1987) Df(1)v-M5 (Zhimulev et al., 1987) Df(1)v-M6 (Zhimulev et al., 1987) Df(1)v-M7 (Zhimulev et al., 1987) Df(1)v-P5 (Zhimulev et al., 1987) Df(1)v-P16 (Zhimulev et al., 1987) Df(1)v-P22 (Zhimulev et al., 1987)
Not duplicated in	Dp(1;2)v+63i (Geer et al., 1983, Zhimulev et al., 1987) Dp(1;Y)v+y+U15 (Zhimulev et al., 1987)
Disrupted in	Df(1)DA622 (Woods and Bryant, 1989, Caggese et al., 1994) Df(1)KA7 (Zhimulev et al., 1987) Df(1)N71 (Zhimulev et al., 1987, Woods and Bryant, 1989, Lahey et al., 1994, Caggese et al., 1994, Tejedor et al., 1997) Df(1)RA37 (Zhimulev et al., 1987, Woods and Bryant, 1989, Caggese et al., 1994)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{dlg1HOOK-FLAG} NA P{dlg1PDZ2+HOOK-FLAG} NA P{dlg1ΔC1:2-FLAG} NA P{dlg1ΔE-F-FLAG} NA P{dlg1ΔGUK-FLAG} NA P{dlg1ΔHOOK-FLAG} NA P{dlg1ΔI3-FLAG} NA P{dlg1ΔN2:3-FLAG} NA P{dlg1ΔN-FLAG} NA P{dlg1ΔPDZ1:2-FLAG} NA P{dlg1ΔPDZ1:3-FLAG} NA P{dlg1ΔPDZ1-FLAG} NA P{dlg1ΔPDZ2:3-FLAG} NA P{dlg1ΔPDZ2-FLAG} NA P{dlg1ΔPDZ3-FLAG} NA P{dlg1ΔSH3-FLAG} NA P{dlg1Δt40-FLAG} NA P{GD4689} NA P{KK116285} NA P{TRiP.GL00188} NA P{TRiP.HMS00014} NA P{TRiP.HMS00024} NA P{TRiP.HMS00172} NA P{TRiP.HMS01521} NA P{TRiP.JF01076} NA P{TRiP.JF01077} NA P{TRiP.JF01365} NA P{TRiP.JF01694} NA P{UAS-dlg1.B} NA P{UAS-dlg1.S97N-EGFP} NA P{UAS-dlg1.SA.GFP} NA P{UAS-dlg1.SD.GFP} NA P{UAS-dlg1.WT.GFP} NA P{UAS-dlg1-EGFP} NA P{UAS-eGFP-dlg1-S48A} NA P{UAS-eGFP-dlg1-S48D} NA P{UAS-eGFP-dlg1-S48S} NA P{UAS-YFP-dlg1.K} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions ?{}dlg12 NA P{PTT-GC}dlg1CC01936 NA P{RS3}dlg1CB-5424-3 NA P{RS5}dlg15-HA-1959 NA PBac{602.P.SVS-1}dlg1CPTI000207 NA PBac{754.P.FSVS-0}dlg1CPTI002569 NA PBac{CPTI-un}dlg1CPTI002860 NA PBac{RB}dlg1e03622 NA PBac{WH}dlg1f03974 NA PBac{WH}dlg1f07937 NA insertion of enhancer trap binary system P{GawB}dlg1NP1102 No P{GawB}dlg1NP4134 No P{GawB}dlg1NP7225 No P{GawB}dlg1PG100 No insertion of mobile activating element P{EPgy2}dlg1EY05003 NA P{Mae-UAS.6.11}dlg1GG01705 NA P{XP}dlg1d08753 NA P{XP}dlg1d10747 NA insertion of enhancer trap P{lacW}dlg1G0276 No P{lacW}dlg1G0342a No P{lacW}dlg1G0342b No P{lacW}dlg1G0456 No P{lacW}dlg1PL32 No
Gene Ontology: Function, Process & Cellular Component ( 51 unique terms )
Terms Based on Experimental Evidence ( 28 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with gukh (Mathew et al., 2002)
Biological Process
CV term Evidence References
asymmetric protein localization inferred from mutant phenotype (Ohshiro et al., 2000, Albertson and Doe, 2003) basal protein localization inferred from mutant phenotype (Peng et al., 2000) central nervous system development inferred from mutant phenotype (Mendoza et al., 2003) establishment of spindle orientation inferred from mutant phenotype (Siegrist and Doe, 2005) establishment or maintenance of polarity of follicular epithelium inferred from genetic interaction with l(2)gl (Bilder et al., 2000) locomotor rhythm inferred from mutant phenotype (Mendoza-Topaz et al., 2008) male courtship behavior inferred from mutant phenotype (Mendoza-Topaz et al., 2008) mating behavior inferred from mutant phenotype (Mendoza-Topaz et al., 2008) morphogenesis of follicular epithelium inferred from mutant phenotype (Bilder et al., 2000) nervous system development inferred from mutant phenotype (Ohshiro et al., 2000) neuron differentiation inferred from mutant phenotype (Mendoza et al., 2003) peripheral nervous system development inferred from mutant phenotype (Mendoza et al., 2003) positive phototaxis inferred from mutant phenotype (Mendoza-Topaz et al., 2008) protein localization inferred from mutant phenotype (Mathew et al., 2002) synaptic growth at neuromuscular junction inferred from mutant phenotype (Zhang et al., 2007) synaptic transmission inferred from mutant phenotype (Koh et al., 1999, Karunanithi et al., 2002)
Cellular Component
CV term Evidence References
apical cortex inferred from direct assay (Peng et al., 2000, Siegrist and Doe, 2005) apicolateral plasma membrane inferred from direct assay (Bilder et al., 2000) cell cortex inferred from direct assay (Ohshiro et al., 2000) lateral plasma membrane inferred from direct assay (Albornoz et al., 2008) neuromuscular junction inferred from direct assay (Kohsaka et al., 2007) perinuclear region of cytoplasm inferred from direct assay (Albornoz et al., 2008) plasma membrane inferred from direct assay (Khanna et al., 2010) inferred from mutant phenotype (Lee et al., 2003) postsynaptic membrane inferred from direct assay (Ashraf et al., 2006) colocalizes_with postsynaptic membrane inferred from direct assay (Kohsaka et al., 2007) colocalizes_with presynaptic membrane inferred from direct assay (Mathew et al., 2002) synapse inferred from direct assay (Zhang et al., 2007) terminal button inferred from direct assay (Mathew et al., 2002)
Terms Based on Predictions or Assertions ( 28 terms )
Molecular Function
CV term Evidence References
epidermal growth factor receptor binding traceable author statement (Humbert et al., 2003) guanylate kinase activity traceable author statement (Koh et al., 1999, Ohshiro et al., 2000) structural molecule activity traceable author statement (Gibson and Schubiger, 2001)
Biological Process
CV term Evidence References
asymmetric protein localization traceable author statement (Wedlich, 2002) asymmetric protein localization involved in cell fate determination traceable author statement (Bardin et al., 2004) basal protein localization non-traceable author statement (Schaefer and Knoblich, 2001) cell proliferation traceable author statement (Bilder et al., 2000) cytoskeleton organization non-traceable author statement (Caruana, 2002) dorsal closure non-traceable author statement (Harden, 2002) traceable author statement (Noselli and Agnes, 1999, Tepass et al., 2001) establishment or maintenance of epithelial cell apical/basal polarity non-traceable author statement (Johnston and Gallant, 2002) traceable author statement (Tepass et al., 2001, Humbert et al., 2003) establishment or maintenance of neuroblast polarity traceable author statement (Tepass et al., 2001) establishment or maintenance of polarity of embryonic epithelium traceable author statement (Ohshiro et al., 2000, Peng et al., 2000) establishment or maintenance of polarity of larval imaginal disc epithelium non-traceable author statement (Tepass et al., 2001) traceable author statement (Bilder et al., 2000) morphogenesis of an epithelium traceable author statement (Tepass et al., 2001) morphogenesis of a polarized epithelium traceable author statement (Gibson and Perrimon, 2003) morphogenesis of larval imaginal disc epithelium traceable author statement (Bilder et al., 2000) negative regulation of cell proliferation traceable author statement (Humbert et al., 2003) protein localization traceable author statement (Noselli and Agnes, 1999, Packard et al., 2003) regulation of border follicle cell delamination traceable author statement (Dobens and Raftery, 2000) regulation of cell cycle non-traceable author statement (Humbert et al., 2003) regulation of cell proliferation traceable author statement (Caruana, 2002) septate junction assembly traceable author statement (Caruana, 2002, Harden, 2002)
Cellular Component
CV term Evidence References
basolateral plasma membrane traceable author statement (Gibson and Perrimon, 2003) cytoskeleton non-traceable author statement (Swiss-Prot Project Members, 1993.7.1) membrane traceable author statement (Koh et al., 1999) plasma membrane non-traceable author statement (FlyBase, 1992-) septate junction non-traceable author statement (Tepass et al., 2001, Harden, 2002) traceable author statement (Noselli and Agnes, 1999, Caruana, 2002, Cereijido et al., 2003, Humbert et al., 2003, Medina et al., 2002) synapse traceable author statement (Packard et al., 2003)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions dlg1 allele Gene References dlg16 CycE (Brumby et al., 2004) dlg114 arm (Greaves et al., 1999) baz (Abdelilah-Seyfried et al., 2003) crb (Tanentzapf and Tepass, 2003) Ras85D (Pagliarini and Xu, 2003) Sh (Thomas et al., 1997) dlg1unspecified scrib (Bilder et al., 2000) unspecified shg (Greaves et al., 1999) sli (Qian et al., 2005) sno (Coyle-Thompson and Jesu, 1997)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 58494 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0001624 DroID - A comprehensive database of gene and protein interactions. • FBgn0001624 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32083
Orthologs
Genome-wide drosophilid orthologs	Dana\GF19076 Dere\GG18413 Dgri\GH12184 Dmoj\GI15715 Dper\GL14854 Dpse\GA14413 Dsec\GM13074 Dsim\GD17020 Dvir\GJ15243 Dwil\GK16228 Dyak\GE15930
Curated drosophilid orthologs	Dhet\dlg1   Dpse\GA14413
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AGAP000255-PA Anopheles gambiae (mosquito) XP_001944265.1 Acyrthosiphon pisum (pea aphid) 255838 Branchiostoma floridae (lancelet) BGIBMGA010382-PA Bombyx mori (silk worm) ENSBTAP00000017813 Bos taurus (bovine) CN09940 Caenorhabditis brenneri (small nematode) CBP37541 Caenorhabditis briggsae (nematode) CE36524 Caenorhabditis elegans (worm) ENSCAFP00000019662 Canis familiaris (dog) ENSCINP00000009884 Ciona intestinalis (sea squirt) JA14511 Caenorhabditis japonica (nematode) CPIJ009531 Culex pipens (mosquito) ENSCPOP00000009777 Cavia porcellus (guinea pig) RP28989 Caenorhabditis remanei (nematode) ENSCSAVP00000015687 Ciona savignyi (sedentary tunicate) 217798 Capitella spl (polychaete worm) 214226 Daphnia pulex (daphnia) ENSDARP00000073316 Danio rerio (zebra fish) ENSECAP00000010309 Equus caballus (horse) ENSGACP00000027364 Gymnopilus aculeatus (mushroom) ENSGALP00000011181 Gallus gallus (chicken) 95514 Hypsipyla robusta (cedar shoot borer) ENSP00000345731 Homo sapiens (human) 209 Monocosta brevicollis (choanoflagellate) ENSMODP00000007980 Monodelphis domestica (gray opossum) ENSMMUP00000021791 Macaca mulatta (rhesus monkey) ENSMUSP00000064280 Mus musculus (house mouse) ENSOANP00000013925 Ornithorynchus anatinus (platypus) ENSORLP00000009557 Oryzias latipes (japanese killifish) PP26706 Pristionchus pacificus (nematode) ENSPPYP00000016163 Pongo pygmaeus (orangutan) 93809 Phytophthora ramorum (sudden oak death pathogen) ENSPTRP00000027175 Pan troglodytes (chimpanzee) ENSRNOP00000055673 Rattus norvegicus (norway rat) Smp_170290 Schistosoma mansoni (trematode parasite) XP_797198.2 Strongylocentrotus purpuratus (purple sea urchin) 63520 Trichoplax adhaerens (metazoa) XP_001815997.1 Tribolium castaneum (red flour beetle) ENSTNIP00000012935 Tetraodon nigroviridis (green spotted pufferfish) ENSTNIP00000019941 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000003441 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000007496 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16839 NV10278 LH23301 FBgn0233489 FBgn0218231 FBgn0202440 FBgn0168007 JGI_V11_214226 FBgn0247742 FBgn0244691 FBgn0152460 FBgn0152459 FBgn0138465 FBgn0119664 FBgn0110629 FBgn0096089 CPIJ009531 BGIBMGA010382 ACYPI007653 ACYPI006699 GB30138 GB14011 AGAP000255 AAEL016988 PHUM577960 GLEAN_00855
Stocks & Reagents
Stocks Listed in FlyBase ( 32 )
Bloomington	36280 dlg15/FM7a 36278 y1 w* dlg12/FM7a 36279 y1 w* dlg118/FM7a
Harvard	- P{XP}dlg1d08753 - P{XP}dlg1d10747 - PBac{RB}dlg1e03622 - PBac{WH}dlg1f03974 - PBac{WH}dlg1f07937
Kyoto	123617 w1118 P{RS3}dlg1CB-5424-3 125496 w1118 P{RS5}dlg15-HA-1959
VDRC	v41134 w1118; P{GD4689}v41134 v41136 w1118; P{GD4689}v41136/TM3
	More stocks available...
Genomic Clones ( 2 )
	BACR07P15 BACR28L07 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 199 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH01107 IP15321 LD04727 LD10659 LD33841 RE30311
Other clones	AF171794 DPiM_GH01107 DPiM_LD33841 MIP06293
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH15958 GH18117 GH23176 GH27140 GM09556 LD02441 LD03505 LD07111 LD40542 LD47071 LP07807 LP12610 LP12648 RE02589 RE03350 RE05583 RE08987 RE23079 RE24631 RE30395 RE30579 RE36470 RE57748 RE63349 RE69083 RE71009 RH10178 RH14146 RH16778 RH39089 RH43373 RH52758 SD02152
Other clones	11862 11926 15527 15644 18268 19350 29825 34561 34979 46986 52599 57598 58899 70139 70672 72445 73495 75088 78209 80568 97203 102725 107383 107507 108088 117489 119548 121999 146004 153400 164370 172923 175194.1 190282 193748 214211.7 214339.7 214411.6 214477.7 214479.5 214511.4 274031 274225 568888 571280 CK01.6C.H7 CK01.11A.C3 CK01.12C.H7 CK01.22C.E6 CK01.26B.E9 CK01.31D.F2 CK01.33D.C6 CK01.43C.G3 CK01.56A.E6 CK01.72B.H10 CK01.79C.H10 CK01.87C.C7 CK01.87C.G7 CK01.91D.B12 CK01.91D.E6 CK01.92B.D9 CK01.94B.D10 CK01.96A.H4 CK01.100B.F11 CK01.101D.H1 CK01.109A.D9 CK01.144A.G5 CK01.169D.C2 Dmel_dig_006779_0612_1408 Dmel_dig_010795_0691_0812 Dmel_neb_010548_0112_1326 Dmel_neb_012048_0923_0455 Dmel_neb_013793_0165_3199 Dmel_neb_014132_0889_2957 EC36536 EK009822 EK012910 EK014803 EK025114 EK027453 EK036826 EK045139 EK056708 EK057263 EK061861 EK064203 EK065406 EK069128 EK071740 EK071851 EK072015 EK073347 EK074662 EK085829 EK088918 EK098713 EK104141 EK112052 EK118406 EK118627 EK131964 EK132332 EK142609 EK144818 EK145454 EK165313 EK168744 EK171116 EK178629 EK181911 EK189501 EK197564 EK201225 EK205025 EK212735 EK233651 EK233741 EK239701 EK242125 EK244623 EK249018 EK290111 EK290608 EK292123 EK301158 EK301921 EN14127 EN16517 EP10758 EP15933 EP18245 EP18847 EP19759 FGH101A07 FGM211B08 FGM212F04 FGM214H06 FGM301E02 FGM317D03 IP15221 RP004121192 RP004139642 RP004201397 RP004210006 RP004242472 RP004246064 RP004250740 RP004251922 RP004264906 RP004464133 RP004478213 RP004486695 RP004518081 RP004521395 RP004547497 RP004550441
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0001624 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32083
Antibody Information
	polyclonal (Woods and Bryant, 1991) polyclonal antibody (Szafranski and Goode, 2004)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: dlg1 CG1725 (Zhong, 1999.11)
Source for database merge of	Source for merge of: dlg1 anon-EST:Posey93 (FlyBase Genome Annotators, 2005) Source for merge of: dlg1 anon-WO03040301.258 anon-WO03040301.260 anon-WO03040301.268 (FlyBase, 1996-) Source for merge of: dlg1 CG1730 (FlyBase Genome Annotators, 2002-2003) Source for merge of: dlg1 l(1)G0276 l(1)G0456 l(1)G0342 (Peter et al., 2002)
Additional comments	Annotations CG1725 and CG1730 merged as CG1725 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Source for merge of dlg1 anon-WO03040301.258 anon-WO03040301.260 anon-WO03040301.268 was sequence comparison (date:051113). (FlyBase, 1996-)
Other Comments
	dlg1 protein is required for the microtubule-induced cortical polarity of the raps and G-iα65A proteins in neuroblasts. (Siegrist and Doe, 2005) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Vap-33-1 and dlg1 localize asymmetrically at the synapse during bouton budding. (Pennetta et al., 2002) baz, raps and dlg1 establish and maintain planar polarity in pI cells. (Bellaiche et al., 2001) The l(2)gl and dlg1 products act in a common process that differentially mediates cortical protein targeting in mitotic neuroblasts, creating intrinsic differences between daughter cells. (Ohshiro et al., 2000) The dlg1 product regulates the localization of l(2)gl. (Ohshiro et al., 2000) The l(2)gl and dlg1 gene products regulate basal protein targeting, but not apical complex formation or spindle orientation, in both embryonic and larval neuroblasts. The l(2)gl and dlg1 proteins promote, and that of zip inhibits, actomyosin dependent basal protein targeting in neuroblasts. (Peng et al., 2000) dlg1 and CaMKII protein colocalise at synapses and exist in the same protein complex. (Koh et al., 1999) Functional analysis of the MAGUK domains of dlg1 in vivo. (Hough et al., 1997) The dlg1 gene product is not required for the localization of glutamate receptors at synapses. (Petersen et al., 1997) The dlg1 product colocalises with Sh K+ channels, which are clustered at glutamatergic synapses at the larval neuromuscular junction. Results demonstrate dlg1 plays an important role in synaptic organisation in vivo that correlates with its ability to bind directly to specific membrane proteins of the synapse. (Tejedor et al., 1997) Some of the proteins of apico-lateral junctions are required both for apico-basal cell polarity and for the signalling mechanisms controlling cell proliferation, whereas others are required more specifically in cell-cell signalling. (Woods et al., 1997) The C-terminal sequences of Fas2 and Sh are both necessary and sufficient for targeting to the subsynaptic muscle membrane at the larval neuromuscular junction, and this localization depends on the product of dlg1. (Zito et al., 1997) Mutations in dlg1 can result in postsynaptic structural defects and large synaptic currents at neuromuscular junctions. Targetted expression of dlg1 using Scer\GAL4 can substantially rescue the reduced postsynaptic structure and presynaptic expression can rescue the physiological defect. Levels of postsynaptic dlg1 regulate or determine subsynaptic reticulum (SSR) size. Results suggest that dlg1 functions in the regulation of neurotransmitter release and postsynaptic structure. (Budnik et al., 1996) The expression of dlg1 during synaptogenesis and synapse maturation has been studied. (Guan et al., 1996) dlg1 protein is localised on the cytoplasmic face of the septate junction and is required for the maintenance of this structure. dlg1 is also required for proper organisation of the cytoskeleton, for the differential location of membrane proteins and for apicobasal polarity of epithelial cells. These functions can be uncoupled from dlg1s role as a tumour suppressor since mutations in two domains of the protein (SH3 and GUK) cause loss of normal cell proliferation control without affecting the other functions of the protein. (Woods et al., 1996) Drosophila homolog of rat PSD-95. (Kim et al., 1995) In addition to its function as a tumor suppressor, the dlg1 gene is required for proper formation of neuromuscular synapses. (Thomas et al., 1995) dlg1 immunoreactivity is expressed at one type of glutamatergic synapse and is associated with both presynaptic and postsynaptic membranes. Mutations in dlg1 alter the expression and cause striking changes in the structure of the subsynaptic reticulum, a postsynaptic specialisation at these synapses. Results indicate that dlg1 is required for normal synaptic structure. (Lahey et al., 1994) Mutants display an imaginal disc neoplastic phenotype. (Mechler, 1994) Endocrine mechanisms responsible for the prolongation of larval life in dlg1 mutants have been investigated: results suggest that delayed pupariation is caused by the overgrown imaginal discs inhibiting the production or release of ecdysteroids from the endocrine system. (Sehnal and Bryant, 1993) Reduced ecdysteroid titer and delayed or blocked metamorphosis in mutants may be a result of altered neuropeptide production, which is probably secondary to the imaginal disc overgrowth. (Zitnan et al., 1993) Mutant analysis of dlg1 suggests that cell-cell interaction and communication is required for the termination of disc cell proliferation. This must occur prior to cellular response to ecdysone. (Abbott and Natzle, 1992) Mutations cause neoplastic imaginal overgrowth. (Bryant and Woods, 1992) A protein, PSD-95, similar to the dlg1 tumour suppressor protein has been found in the rat brain. dlg1 protein is associated with septate junctions in developing flies and contains a guanylate kinase domain that is required for normal control of cell division. (Cho et al., 1992) Mutant analysis demonstrates that the dlg1 gene product is a guanylate kinase homolog located in a small apical belt of the lateral cell membrane coinciding in position with the septate junction. (Woods and Bryant, 1991) The developmental profile of dlg1 transcription has been investigated. (Woods and Bryant, 1989) dlg1 has been isolated and characterized. (Woods and Bryant, 1989) Late larval lethal; prolonged larval stages with bloated larvae attempting pupariation around day 15; some cuticular tanning, but no adult cuticular structures formed. During early larval development, the imaginal discs are smaller than those of normal larvae of the same age and are misshapen, but as the larvae continue to survive after the normal pupariation time, the discs continue to grow. They become large, amorphous and solid, containing three times the normal numbers of cells at ten days of age; they also experience substantial cell death. By eleven days, wing and haltere discs may fuse; also first and second leg discs fuse with ventral ganglion of the CNS; great enlargement of optic lobes of brain also takes place. Discs, but not brains, transplanted into adults grow rapidly displaying invasive growth; they do not differentiate when transplanted into larvae for metamorphosis. Homozygous tissues do not survive, nor do gynandromorphs (one with male abdominal tissue vs. 66 expected). It is possible to produce homozygous germ-line clones (Perrimon, 1988). dlg1 embryos generated from such clones display defects in morphogenesis and neurogenesis; most tissues are defective; partial rescue achieved by a paternal dlg1+ contribution, in the form of either a normal X or a v+Y.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078565 NM_167280 NM_167281 NM_167282 NM_206679 NM_206680 NM_206681 NM_206682 NM_206683 NM_206684 NM_001103485 NM_001103486 NM_001169247 NM_001169248 NM_001169249 RefSeq (Proteins) • NP_511120 NP_727518 NP_727519 NP_727520 NP_996402 NP_996403 NP_996404 NP_996405 NP_996406 NP_996407 NP_001096955 NP_001096956 NP_001162718 NP_001162719 NP_001162720 DDBJ / EMBL / GenBank • AA391639 AA979335 AAA28468 AAF48037 AAF48037.2 AAF48038 AAF48038.2 AAF48039 AAF48039.2 AAL13339 AAL39553 AAL68235 AAN09630 AAN09630.1 AAQ01226 AAS65308 AAS65308.1 AAS65309 AAS65309.1 AAS65310 AAS65310.1 AAS65311 AAS65311.1 AAS65312 AAS65312.1 AAS65313 AAS65313.1 AAY83340 ABW09394 ABW09395 ACZ95253 ACZ95254 ACZ95255 AF171794 AI062058 AJ426861 AJ426862 AW940096 AW942147 AX777404 AX777406 AX777414 AY059433 AY069408 AY075410 AY332243 CZ476394 CZ477415 CZ481376 CZ481377 CZ490653 DQ066624 M73529 Entrez Gene - A searchable database of RefSeq genes. • 32083 UniProtKB/Swiss-Prot • P31007 UniProtKB/TrEMBL • C1C536 E1JJH5 E1JJH6 Q4PLW2
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Src homology-3 domain (IPR001452) PDZ/DHR/GLGF (IPR001478) L27 (IPR004172) Guanylate kinase (IPR008144) Guanylate kinase/L-type calcium channel (IPR008145) L27-1 (IPR015143) Guanylate kinase, conserved site (IPR020590) Variant SH3 (IPR011511)
Linkouts
	BioGRID - A database of protein and genetic interactions • 58494 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0001624 DroID - A comprehensive database of gene and protein interactions. • FBgn0001624 DRSC - Results from RNAi screens. • FBgn0001624 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001624 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1725-RD;CG1725-RC;CG1725-RF;CG1725-RF FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0001624 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32083 InParanoid A subset of ortholog calls from InParanoid. • AGAP000255-PA Anopheles gambiae (mosquito) XP_001944265.1 Acyrthosiphon pisum (pea aphid) 255838 Branchiostoma floridae (lancelet) BGIBMGA010382-PA Bombyx mori (silk worm) ENSBTAP00000017813 Bos taurus (bovine) CN09940 Caenorhabditis brenneri (small nematode) CBP37541 Caenorhabditis briggsae (nematode) CE36524 Caenorhabditis elegans (worm) ENSCAFP00000019662 Canis familiaris (dog) ENSCINP00000009884 Ciona intestinalis (sea squirt) JA14511 Caenorhabditis japonica (nematode) CPIJ009531 Culex pipens (mosquito) ENSCPOP00000009777 Cavia porcellus (guinea pig) RP28989 Caenorhabditis remanei (nematode) ENSCSAVP00000015687 Ciona savignyi (sedentary tunicate) 217798 Capitella spl (polychaete worm) 214226 Daphnia pulex (daphnia) ENSDARP00000073316 Danio rerio (zebra fish) ENSECAP00000010309 Equus caballus (horse) ENSGACP00000027364 Gymnopilus aculeatus (mushroom) ENSGALP00000011181 Gallus gallus (chicken) 95514 Hypsipyla robusta (cedar shoot borer) ENSP00000345731 Homo sapiens (human) 209 Monocosta brevicollis (choanoflagellate) ENSMODP00000007980 Monodelphis domestica (gray opossum) ENSMMUP00000021791 Macaca mulatta (rhesus monkey) ENSMUSP00000064280 Mus musculus (house mouse) ENSOANP00000013925 Ornithorynchus anatinus (platypus) ENSORLP00000009557 Oryzias latipes (japanese killifish) PP26706 Pristionchus pacificus (nematode) ENSPPYP00000016163 Pongo pygmaeus (orangutan) 93809 Phytophthora ramorum (sudden oak death pathogen) ENSPTRP00000027175 Pan troglodytes (chimpanzee) ENSRNOP00000055673 Rattus norvegicus (norway rat) Smp_170290 Schistosoma mansoni (trematode parasite) XP_797198.2 Strongylocentrotus purpuratus (purple sea urchin) 63520 Trichoplax adhaerens (metazoa) XP_001815997.1 Tribolium castaneum (red flour beetle) ENSTNIP00000012935 Tetraodon nigroviridis (green spotted pufferfish) ENSTNIP00000019941 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000003441 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000007496 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /newgene/disclrg1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32083 modMine - Data generated by the modENCODE project. • FBgn0001624 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB16839 NV10278 LH23301 FBgn0233489 FBgn0218231 FBgn0202440 FBgn0168007 JGI_V11_214226 FBgn0247742 FBgn0244691 FBgn0152460 FBgn0152459 FBgn0138465 FBgn0119664 FBgn0110629 FBgn0096089 CPIJ009531 BGIBMGA010382 ACYPI007653 ACYPI006699 GB30138 GB14011 AGAP000255 AAEL016988 PHUM577960 GLEAN_00855
Synonyms & Secondary IDs ( 60 )
Reported As
Symbol Synonym	11 (Lefevre and Watkins, 1986, Lefevre, 1981) anon-EST:Posey93 (Ashburner, 2004.6.30, ) anon-WO03040301.258   anon-WO03040301.260   anon-WO03040301.268   CG1725 (Bourbon et al., 2002, Quinones-Coello, 2007, Perkins et al., 1.15.2009, Khanna et al., 2010, Ni et al., 2008, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Ni et al., 2011.7.19, Cammarato et al., 2011) CG1730 (Ni et al., 2008) CPD (Lee et al., 2002) d. lg.-1 (Mason et al., 1990) Discs-large (Le Borgne et al., 2005) dlg (Zhao et al., 2008, Werz et al., 2005, Dunlop et al., 2004, Bachmann et al., 2004, Le Borgne and Schweisguth, 2003, Mendoza et al., 2003, Karunanithi et al., 2002, Brumby et al., 2004, Roegiers and Jan, 2004, Dudu et al., 2004, Zhao et al., 2005, Goode et al., 2005, Cho, 2005, Bilder, 2004, Szafranski and Goode, 2004, Kuppers-Munther et al., 2004, Pagliarini and Xu, 2003, Gibson and Perrimon, 2003, Wodarz and Huttner, 2003, Radovic and Bryant, 2003, Doe and Bowerman, 2001, Johnson and Wodarz, 2003, Lecuit and Pilot, 2003, Bilder et al., 2003, Tanentzapf and Tepass, 2003, Albertson and Doe, 2003, Kaltschmidt et al., 2002, Medina et al., 2002, Humbert et al., 2003, Drapeau et al., 2003, Abdelilah-Seyfried et al., 2003, Chia and Yang, 2002, Adler, 2002, Greaves, 2001, Doe, 2001, Goode, 2000, Caruana, 2002, Schaefer and Knoblich, 2001, Muller, 2003, Wedlich, 2002, Cross et al., 2003, Papagiannouli et al., 2003, Marhold et al., 2003, Pennetta et al., 2002, Kaufmann et al., 2002, Cross et al., 2002, Marhold et al., 2002, Leeds and Coyle-Thompson, 2002, Mathew et al., 2001, Kuchinke et al., 2001, Karunanithi et al., 2001, Wodarz, 2001, Johnston and Gallant, 2002, Tepass et al., 2001, Hardie and Raghu, 2001, Wu et al., 2001, Luxenberg et al., 2001, Bellaiche et al., 2001, Bilder, 2001, Radovic et al., 2001, Ramon and Coyle-Thompson, 2001, Tanentzapf and Tepass, 2001, Ohshiro et al., 2001, Peng et al., 2000, Ohshiro et al., 2000, Greaves, 2000, Wodarz, 2000, Thomas et al., 2000, Sone et al., 2000, Peifer, 2000, Muller, 2000, Dobens and Raftery, 2000, Bilder et al., 2000, Littleton and Ganetzky, 2000, Andrew et al., 2000, Ramon et al., 2000, Radovic et al., 2000, Atwood et al., 1999, Turenchalk et al., 1999, Greaves et al., 1999, Bilder et al., 1999, Koh et al., 1999, Torroja et al., 1999, Prokop, 1999, Rohrbough et al., 1999, McGee and Bredt, 1999, Kim and Huganir, 1999, Jesu et al., 1999, Bilder and Perrimon, 1999, Agnes and Noselli, 1999, Kondo, 1998, Gundelfinger et al., 1998, Woods et al., 1998, Craven and Bredt, 1998, Woodhouse et al., 1998, Ward et al., 1998, Jesu et al., 1998, Jesu et al., 1998, Biessmann and Walter, 1998, Petersen et al., 1997, Noselli, 1998, Hough et al., 1997, Bryant, 1993, Zito et al., 1997, Thomas et al., 1997, Ruiz-Cathada et al., 1997, Kim, 1997, Izaddoost et al., 1997, Thomas et al., 1997, Sheng and Wyszynski, 1997, Goode and Perrimon, 1997, Makino et al., 1997, Littlejohn et al., 1997, Ponting et al., 1997, Woods et al., 1997, Trimmer and Rhodes, 1997, Dimitratos et al., 1997, Bryant, 1997, Budnik, 1996, Brunner and O'Kane, 1997, Goode and Perrimon, 1997, Fagotto and Gumbiner, 1996, Fanning and Anderson, 1996, Woods et al., 1996, Budnik et al., 1996, Guan et al., 1996, Kim, 1995, Peifer, 1996, Hough et al., 1996, Budnik et al., 1995, Kirkpatrick and Peifer, 1995, Watson et al., 1994, Shieh and Niemeyer, 1995, Mechler, 1994, Gateff, 1994, Goode and Perrimon, 1995, Woods and Bryant, 1993, Peifer et al., 1993, Bryant et al., 1993, Woods and Bryant, 1993, Boedigheimer et al., 1993, Binari and Perrimon, 1994, Sehnal and Bryant, 1993, Garner et al., 1993, Skaer, 1993, Zitnan et al., 1993, Koonin et al., 1992, Woods and Bryant, 1992, Woods and Bryant, 1991, Bryant and Schmidt, 1990, Richardson et al., 2005, Zhao et al., 2006, Szafranski and Goode, 2006, Hall et al., 2006, Denef et al., 2006, Wirtz-Peitz and Knoblich, 2006, Humbert et al., 2006, Wodarz and Gonzalez, 2006, Djiane et al., 2005, Janody and Treisman, 2006, Emery et al., 2005, Mathew et al., 2002, Wiggin et al., 2005, Mendoza-Topaz et al., 2008, Guthridge et al., 2007, Tountas and Fortini, 2007, D'Costa et al., 2006, Goode et al., 2005, Bao et al., 2007, Yang et al., 2005, Lecuit, 2004, Chia et al., 2008, Wei et al., 2004, Hackney et al., 2007, Gorczyca et al., 2007, Laprise et al., 2006, Jankovics and Brunner, 2006, Denef et al., 2008, Zhang et al., 2007, Heckscher et al., 2007, Pielage et al., 2008, Rodal et al., 2008, Blankenship et al., 2007, Moyer and Jacobs, 2008, Donlea et al., 2009, Ohsawa et al., 2011, Courbard et al., 2009, Igaki et al., 2006, Igaki et al., 2006, Grosskortenhaus et al., 2005, Viquez et al., 2006, Katsuki et al., 2009, Ni et al., 2009, Kohsaka et al., 2007, Li et al., 2009, Laprise et al., 2010, Grzeschik et al., 2010, Franz and Riechmann, 2010, Walther and Pichaud, 2010, Cordero et al., 2010, Mao and Freeman, 2009, Fichelson et al., 2010, Simone and DiNardo, 2010, Bahri et al., 2010, Bachmann et al., 2010, Bachmann et al., 2010, Garlena et al., 2010, Fernandez-Minan et al., 2008, Grifoni et al., 2004, Dow et al., 2003, Buchon et al., 2010, Kaplan et al., 2009, Kitajima et al., 2010, Thomson and Johnson, 2010, Albornoz et al., 2008, Letizia et al., 2011, Pastor-Pareja et al., 2008, Cabernard et al., 2010) DLG (Liebl et al., 2005, Singh et al., 2005, Montana and Littleton, 2004, Genova and Fehon, 2003, Koh et al., 2002, Rosin et al., 2004, Rieckhof et al., 2003, Packard et al., 2003, Benton and St. Johnston, 2003, Schenck et al., 2003, Cereijido et al., 2003, Van Doren et al., 2003, Rushton et al., 2003, Packard et al., 2002, Beumer et al., 2002, Radovic et al., 2002, Kazantsev et al., 2002, Razzaq et al., 2001, Renden et al., 2001, Mathew et al., 2001, Parmentier et al., 2001, Beumer et al., 2001, Kramer, 2000, Bellen, 2000, Seidensticker and Behrens, 2000, Murthy, 1999, Beumer et al., 1999, O'Brien et al., 1998, Parmentier et al., 1999, Gorczyca et al., 1999, Bhat et al., 1999, Koh et al., 1999, Montell, 1998, Baumgartner et al., 1996, Roush, 1996, Thompson and Cohen, 2006, Hiesinger et al., 2005, Dickman et al., 2006, Dickman, 2006, Ataman, 2006, Ashraf et al., 2006, Wang et al., 2006, Rivlin et al., 2004, Ohyama et al., 2007, Haas et al., 2007, Liebl et al., 2008, Ash et al., 2007, Pan et al., 2008, Acharya et al., 2006, Margolis and Borg, 2005, Aravamudan and Broadie, 2003, Pallavi and Shashidhara, 2005, Hebbar et al., 2006, Chen and Featherstone, 2005, Kapelnikov et al., 2008, Cauchi et al., 2008, Kumar et al., 2009, Gilestro et al., 2009, Ramachandran et al., 2009, Beramendi et al., 2007, Rushton et al., 2009, Korkut et al., 2009, Chang et al., 2008, Dickman and Davis, 2009, Fuentes-Medel et al., 2009, Gibson et al., 2011, Ratnaparkhi et al., 2008, Kolodziejczyk et al., 2008, Milton et al., 2010, Mosca and Schwarz, 2010, Kim et al., 2010, Choi et al., 2010, Hamanaka and Meinertzhagen, 2010, Chiang et al., 2011, Morimoto et al., 2010, Varija Raghu et al., 2011, Uytterhoeven et al., 2011, Beerman and Jongens, 2011, Wu et al., 2011, Shih and Chiang, 2011, Lanson et al., 2011) Dlg (Araujo et al., 2005, Munoz-Descalzo et al., 2005, Masuda-Nakagawa et al., 2005, Ferres-Marco et al., 2006, Xu et al., 2005, Pielage et al., 2005, Albin and Davis, 2004, Cho, 2004, Lee et al., 2003, Udan et al., 2003, Rolls et al., 2003, Vaccari et al., 2005, Grosshans et al., 2005, Lim and Choi, 2004, Kato et al., 2004, van Roessel et al., 2004, Wu et al., 2004, Schulte et al., 2003, Roche et al., 2002, Wu and Beitel, 2004, Betschinger and Knoblich, 2004, Strickland and Burgess, 2004, Wu et al., 2005, Hall et al., 2005, Torban et al., 2004, Koh et al., 2004, Bachmann et al., 2003, Horton and Ehlers, 2003, Coyle et al., 2004, Bardin et al., 2004, Wu et al., 2004, Bellaiche et al., 2004, Llimargas et al., 2004, Lim and Choi, 2003, Siegrist and Doe, 2004, Mueller and Bossinger, 2003, Anonymous, 2003, Bilder, 2003, Hoover and Bryant, 2000, Lecuit, 2003, Henrique and Schweisguth, 2003, Bastock et al., 2003, Braga and Harwood, 2001, Bryant and Huwe, 2000, Nelson, 2003, Hemphala et al., 2003, Knust and Bossinger, 2002, Goode and Szafranski, 2003, Zhao et al., 2003, Deng et al., 2003, Kango-Singh et al., 2002, Knox and Brown, 2002, Chern and Choi, 2002, Hebbar and Fernandes, 2002, Hering and Sheng, 2002, Hoover and Bryant, 2002, Verstreken et al., 2002, Aberle et al., 2002, Leventis et al., 2001, Hong et al., 2001, Zelhof et al., 2001, Chase, 2001, Knust, 2001, Bilder, 2001, Bellaiche et al., 2001, Mayer, 2001, Zahraoui et al., 2001, Bienz and Clevers, 2000, Zahraoui et al., 2000, Cho, 2000, Huwe et al., 2000, Dimitratos et al., 1999, Martinez Arias et al., 1999, Yeaman et al., 1999, Noselli and Agnes, 1999, Radovic' et al., 1999, Tsunoda et al., 1998, Craven and Bredt, 1998, Broadie, 1998, Anonymous, 1998, Anonymous, 1998, Brosamle, 1998, Woods et al., 1997, Tepass, 1997, Woods et al., 1997, Woods et al., 1996, Anderson, 1996, Fanning et al., 1993, Wang et al., 2006, Auld et al., 2006, Bogdanik et al., 2008, Le Bivic, 2005, Singh et al., 2006, Dudu, 2006, Siddall et al., 2006, Thompson and Cohen, 2006, McCartney et al., 2006, Muro et al., 2006, Ahringer, 2005, Siegrist and Doe, 2005, Kim et al., 2006, Nolo et al., 2006, Poulton and Deng, 2006, Wei et al., 2005, Harris and Peifer, 2004, Mahr and Aberle, 2006, Dudu et al., 2006, Mirkovic and Mlodzik, 2006, Sommer et al., 2005, Wang et al., 2006, Koh et al., 2007, Schneider et al., 2006, Simoes et al., 2006, Qian and Prehoda, 2006, Pfleger et al., 2007, Bennett and Harvey, 2006, Kolsch et al., 2007, Tian and Ten Hagen, 2007, Tiwari and Roy, 2009, Yu et al., 2008, Merino et al., 2009, Banovic et al., 2010, Stowers and Isacoff, 2007, Langevin et al., 2005, Harris and Peifer, 2005, Sasaki et al., 2007, Nagaraj and Banerjee, 2007, Lovegrove et al., 2006, Bach et al., 2007, Sanchez-Soriano and Prokop, 2005, Lee et al., 2007, Moberg et al., 2005, Meyer and Aberle, 2006, Wu et al., 2007, Pielage et al., 2006, Lee et al., 2002, Jafar-Nejad et al., 2005, Wang et al., 2007, Marques, 2005, Beuchle et al., 2007, Suzuki and Ohno, 2006, Zhao et al., 2007, Murthy et al., 2010, Rohrbough et al., 2007, Szafranski and Goode, 2007, Horne-Badovinac and Bilder, 2008, Menut et al., 2007, Siegrist and Doe, 2006, Harris and Peifer, 2007, Corrigall et al., 2007, Link et al., 2007, Mirouse et al., 2007, Kohsaka et al., 2007, Besse et al., 2007, Albertson et al., 2008, Cao et al., 2008, Grzeschik et al., 2007, Song et al., 2007, Nishimura et al., 2007, Homem and Peifer, 2008, Yasugi et al., 2008, Pope and Harris, 2008, O'Keefe et al., 2007, Conder et al., 2007, Ou et al., 2007, Polesello and Tapon, 2007, O'Connor-Giles et al., 2008, Egger et al., 2007, Banerjee et al., 2008, Vogler and Urban, 2008, Albertson et al., 2004, Bayraktar et al., 2006, Speicher et al., 2008, Walthall et al., 2007, Miech et al., 2008, Chandraratna et al., 2007, Sokac and Wieschaus, 2008, Narasimha et al., 2008, Romani et al., 2009, Schulte et al., 2006, Wairkar et al., 2009, Mirouse et al., 2009, Gorfinkiel and Arias, 2007, Nagaraj and Banerjee, 2009, Campbell et al., 2010, Hamaratoglu et al., 2006, Morrison et al., 2008, Alves-Silva et al., 2008, Korolchuk et al., 2007, Grusche et al., 2009, Rodahl et al., 2009, Widmann and Dahmann, 2009, Giagtzoglou et al., 2009, Ninov et al., 2009, Emes et al., 2008, Peng et al., 2009, Verstreken et al., 2005, Lee et al., 2009, Hamaratoglu et al., 2009, Genevet et al., 2009, Glavic et al., 2009, Laprise et al., 2009, Sekyrova et al., 2010, Peng et al., 2009, Willecke et al., 2008, Baena-Lopez et al., 2008, Sawyer et al., 2009, Woolworth et al., 2009, Lin et al., 2009, Flaherty et al., 2009, Sahota et al., 2009, Massarwa et al., 2009, O'Keefe et al., 2009, Campbell et al., 2009, Yan et al., 2009, Warner and Longmore, 2009, Willecke et al., 2006, Patel et al., 2009, Copeland et al., 2007, Eid et al., 2008, Ly et al., 2008, Kumar et al., 2009, Larson et al., 2008, Guha et al., 2009, Cobreros et al., 2008, Zhang et al., 2009, Warner and Longmore, 2009, Barber et al., 2009, Ogawa et al., 2009, Kim et al., 2009, Langton et al., 2009, Huntwork and Littleton, 2007, Roeth et al., 2009, Pielage et al., 2008, Haines et al., 2007, Martinez et al., 2009, Johnson et al., 2009, Masuda-Nakagawa et al., 2009, Gervais and Casanova, 2010, Krahn et al., 2010, Robinson et al., 2010, Ho et al., 2010, Maynard et al., 2010, Morais-de-Sá et al., 2010, Haglund et al., 2010, Maurel-Zaffran et al., 2010, Lee et al., 2008, Devaud et al., 2008, Fernandes et al., 2010, Yu et al., 2010, Beam and Moberg, 2010, Warner et al., 2010, Chen et al., 2010, Levine et al., 2010, Tamori et al., 2010, Januschke and Gonzalez, 2010, Nelson et al., 2010, Marie et al., 2010, Ekas et al., 2010, Hamel et al., 2010, Graham et al., 2010, Bachmann et al., 2008, Wang and Riechmann, 2007, Zhang et al., 2007, Harumoto et al., 2010, Tikhmyanova et al., 2010, Tsurudome et al., 2010, Daniels et al., 2011, Liu et al., 2010, Padash-Barmchi et al., 2010, Djiane et al., 2011, Kaplan and Tolwinski, 2010, Lee et al., 2010, Roy et al., 2007, Wang et al., 2011, Lee and Thomas, 2011, Müller et al., 2011, Kaplan et al., 2011, Laplante et al., 2010, Hijazi et al., 2011, Nahm et al., 2010, Szul et al., 2011, James and Broihier, 2011, Jiang et al., 2011, Charlton-Perkins et al., 2011, Georgiou and Baum, 2010, Rossetto et al., 2011, Raghu and Borst, 2011, Peng et al., 2009, Khuong et al., 2010, Gilbert et al., 2011, Ball et al., 2010, Ayyub, 2011, Fan et al., 2010, Rohrbough and Broadie, 2010) Dlg1 (Baena-Lopez et al., 2003, Hijazi et al., 2009, Laprise et al., 2009, Ho et al., 2010, Simone and DiNardo, 2010, Bahri et al., 2010) dlg-1 (Thomas et al., 1997, Thomas et al., 1995, Thomas et al., 1995) dlg1 (Wijnen et al., 2006, Buszczak et al., 2007, Quinones-Coello, 2007, Lecuyer et al., 2007, Dietzl et al., 2007, Rasse et al., 2005, Bakal et al., 2008, Tyler and Baker, 2007, Junion et al., 2007, Dworkin et al., 2009, Chen et al., 2008, Ni et al., 2009, Popodi et al., 2010-, Dow et al., 2003, Kim and Marqués, 2010) Dlg-A (Mendoza et al., 2003) dlg-A (Fanning and Anderson, 1999, Woods and Bryant, 1992, ) DLG-A (Inagaki et al., 2001) DlgA (Thomas et al., 1997, Balda and Matter, 1998, Garner and Kindler, 1996, Saras and Heldin, 1996, Kurzchalia and Hartmann, 1996) dlgA (Dale, 1998, Mendoza-Topaz et al., 2008) dlgS97 (Mendoza-Topaz et al., 2008) Drodlg (Gorry et al., 1996) l(1)10Bf (Caggese et al., 1994, ) l(1)bwn (Gateff, 1977, Gateff, 1978) l(1)d.lg-1 (Woods and Bryant, 1989, Poodry and Woods, 1990, Loffler et al., 1990, Mechler, 1990, Woods and Bryant, 1989, Gateff and Mechler, 1989, ) l(1)d.lg.-1 (Gateff, 1978) l(1)discs large (Fristrom and Fristrom, 1993, Cohen, 1993) l(1)dlg (Madueno et al., 1995, Lahey et al., 1994, Segal, 1993) l(1)dlg1 (Madueno et al., 1995, ) l(1)dlg-1 (Abbott and Schenkel, 1992, Abbott and Natzle, 1992, Schmidt, 1989) l(1)G19   l(1)G0276 (Schaefer et al., 1999.6.15, ) l(1)G0342 (Schaefer et al., 1999.8.12, ) l(1)G0456 (Schaefer et al., 1999.12.14, ) l(1)L11 (Zhimulev et al., 1987) l(1)l.pr.-2   l(1)lpr-2 (Kiss et al., 1978) misb (Cross et al., 2003, Cross et al., 2002, Jesu et al., 1998) PSD95 (Marques, 2005) SAP97 (Lecuit, 2004)
Name Synonym	disc-large (Polesello and Payre, 2004) Disc Large (Cordero et al., 2004, Swanson and Beitel, 2006, Beramendi et al., 2007, Reeve et al., 2008) disc large (Nurminsky, 2007, Cordero et al., 2010) Disc large (Tiwari and Roy, 2009, Nagaraj and Banerjee, 2009, Qurashi et al., 2007, Cobreros et al., 2008, Varija Raghu et al., 2011) Disc-large (Wang et al., 2007, Ho et al., 2010) Discslarge (Zhao et al., 2008, Goode et al., 2005, Szafranski et al., 2004) discs large (Kurshan et al., 2009, Rodriguez-Boulan et al., 2004, Levine, 2004, Delmas et al., 2004, Eaton and Davis, 2003, Paul et al., 2003, Landgraf et al., 2003, Wedlich, 2002, Guan et al., 1996, Coyle-Thompson and Sparling, 2007, Tountas and Fortini, 2007, Goode et al., 2005, Haas et al., 2007, Huang et al., 2006, Chia et al., 2008, Albertson et al., 2008, Eid et al., 2008, Larson et al., 2008, Dickman and Davis, 2009, Li et al., 2009, Laprise et al., 2010, Devaud et al., 2008, Fernandez-Minan et al., 2008, Chiang et al., 2011, Grifoni et al., 2004, Dow et al., 2003, Thomson and Johnson, 2010, Lanson et al., 2011, Rossetto et al., 2011) Discs large (Wu et al., 2005, Schneeberger and Raabe, 2003, Gibson and Schubiger, 2001, Chan et al., 2003, Hipfner et al., 2004, Martinez Arias et al., 1999, Muro et al., 2006, Kim et al., 2006, Poulton and Deng, 2006, Harris and Peifer, 2004, Sommer et al., 2005, Bennett and Harvey, 2006, Ash et al., 2007, Stowers and Isacoff, 2007, Sasaki et al., 2007, Sanchez-Soriano and Prokop, 2005, Lecuit, 2004, Suzuki and Ohno, 2006, Hackney et al., 2007, Krieser et al., 2007, Mirouse et al., 2007, Polesello and Tapon, 2007, Chandraratna et al., 2007, Schulte et al., 2006, Blankenship et al., 2007, Hamaratoglu et al., 2009, Laprise et al., 2009, Sahota et al., 2009, Massarwa et al., 2009, O'Keefe et al., 2009, Ribaya et al., 2009, Warner and Longmore, 2009, Patel et al., 2009, Kondo et al., 2007, Guha et al., 2009, Forster et al., 2010, Warner and Longmore, 2009, Kim et al., 2009, Langton et al., 2009, Huntwork and Littleton, 2007, Krahn et al., 2010, Grzeschik et al., 2010, Robinson et al., 2010, Franz and Riechmann, 2010, Maynard et al., 2010, Ratnaparkhi et al., 2008, Kolodziejczyk et al., 2008, Maurel-Zaffran et al., 2010, Warner et al., 2010, Chen et al., 2010, Tamori et al., 2010, Nelson et al., 2010, Hamel et al., 2010, Milton et al., 2010, Simone and DiNardo, 2010, Bahri et al., 2010, Murthy et al., 2010, Kim et al., 2010, Choi et al., 2010, Tsurudome et al., 2010, Padash-Barmchi et al., 2010, Park et al., 2011, Masuda-Nakagawa et al., 2010, Buchon et al., 2010, Lee and Wu, 2010, Kaplan et al., 2009, Syed et al., 2011, Szul et al., 2011, Gilbert et al., 2011, Ayyub, 2011, Rohrbough and Broadie, 2010) discs-large (Venema and Auld, 2003, Venema and Auld, 2003, Venema and Auld, 2001, Celniker, 2000, Morel and Arias, 2004, Le Borgne and Schweisguth, 2003, Roegiers and Jan, 2004, Wolfgang et al., 2004, Goode, 2000, Dickman et al., 2006, Chen and Featherstone, 2005, Donlea et al., 2009, Ni et al., 2009, Bachmann et al., 2010, Hamanaka and Meinertzhagen, 2010) Discs-Large (Eaton et al., 2002, Parmentier et al., 2000, Cao et al., 2008, Wairkar et al., 2009, Morrison et al., 2008, Katsuki et al., 2009, Kohsaka et al., 2007, Lee et al., 2008, Bogdanik et al., 2008, Roy et al., 2007) Discs-large (Featherstone et al., 2000, Fehon, 2006, Duchi et al., 2007, Romani et al., 2007, Pielage et al., 2006, Vogler et al., 2008, van der Plas et al., 2006, Szafranski and Goode, 2007, Horne-Badovinac and Bilder, 2008, Jaekel and Klein, 2006, Langton et al., 2007, O'Keefe et al., 2007, Walthall et al., 2007, Mirouse et al., 2009, Rodahl et al., 2009, Gilestro et al., 2009, Martinez et al., 2009, Müller et al., 2011) discslarge (Goode et al., 1996) Discs Large (Wu and Beitel, 2004, Mahr and Aberle, 2006, Wang et al., 2006, Zhang and Ward, 2009, Lee et al., 2002, Rasse et al., 2005, Margolis and Borg, 2005, Wei et al., 2004, Harris and Peifer, 2007, Tyler and Baker, 2007, Song et al., 2007, Seppa et al., 2008, Speicher et al., 2008, Kapelnikov et al., 2008, Chang et al., 2008, Cobreros et al., 2008, Haines et al., 2007, Johnson et al., 2009, Beam and Moberg, 2010, Levine et al., 2010, Fichelson et al., 2010, Mosca and Schwarz, 2010, Tsurudome et al., 2010, Laplante and Nilson, 2011, Lee and Thomas, 2011, Laplante et al., 2010) discs large 1 (Bakal et al., 2008, Letizia et al., 2011, Cammarato et al., 2011) Discs large 1 (Matakatsu and Blair, 2008, Hijazi et al., 2009, Sekyrova et al., 2010, Khanna et al., 2010) Disk Large (Rusten et al., 2006) lethal(1)benign wing imaginal disc neoplasm (Gateff, 1977) lethal(1)discs-large (de Lorenzo et al., 2003, Caruana, 2002, Huwe et al., 2000) lethal(1)discs large (Knust, 1994) lethal(2)discs large (Biessmann and Walter, 1998)
Secondary FlyBase IDs
	FBgn0010108 FBgn0027239 FBgn0027662 FBgn0028321 FBgn0029052 FBgn0030295 FBgn0066811 FBgn0066812 FBgn0066813
References ( 802 )
Generate a list of	All references relating to this gene ( 802 )
List References by type	Research paper  ( 502 ) Supplementary material  ( 15 ) Review  ( 147 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 99 ) FlyBase analysis  ( 5 ) Conference report  ( 6 ) Letter  ( 4 ) Book review  ( 1 ) Curated genome annotation  ( 1 ) Protein sequence record  ( 1 ) Computer file  ( 4 ) DNA/RNA sequence record  ( 1 ) Automatic genome annotation  ( 1 ) Book  ( 1 ) Patent  ( 1 )
Recent research papers ( 95 )
	Ayyub, 2011, J. Genet. 90(2): 239--249 Cullin-5 and cullin-2 play a role in the development of neuromuscular junction and the female germ line of Drosophila. [FBrf0214802] Beerman and Jongens, 2011, Neuroscience 181: 48--66 A non-canonical start codon in the Drosophila fragile X gene yields two functional isoforms. [FBrf0213401] Charlton-Perkins et al., 2011, Neural Dev. 6: 20 Prospero and Pax2 combinatorially control neural cell fate decisions by modulating Ras- and Notch-dependent signaling. [FBrf0213993] Chiang et al., 2011, Curr. Biol. 21(1): 1--11 Three-Dimensional Reconstruction of Brain-wide Wiring Networks in Drosophila at Single-Cell Resolution. [FBrf0212704] Daniels et al., 2011, Neurobiol. Disease 41(2): 415--420 Increased vesicular glutamate transporter expression causes excitotoxic neurodegeneration. [FBrf0212635] Djiane et al., 2011, J. Cell Biol. 192(1): 189--200 Su(dx) E3 ubiquitin ligase-dependent and -independent functions of Polychaetoid, the Drosophila ZO-1 homologue. [FBrf0212737] Gibson et al., 2011, Cell 144(3): 427--438 Control of the mitotic cleavage plane by local epithelial topology. [FBrf0214365] Gilbert et al., 2011, Dev. Cell 20(5): 700--712 A Screen for Conditional Growth Suppressor Genes Identifies the Drosophila Homolog of HD-PTP as a Regulator of the Oncoprotein Yorkie. [FBrf0213686] Hijazi et al., 2011, PLoS ONE 6(3): e17763 The ly6 protein coiled is required for septate junction and blood brain barrier organisation in Drosophila. [FBrf0213269] James and Broihier, 2011, Development 138(15): 3273--3286 Crimpy inhibits the BMP homolog Gbb in motoneurons to enable proper growth control at the Drosophila neuromuscular junction. [FBrf0214390] Jiang et al., 2011, Oncogene 30(29): 3248--3260 Sds22/PP1 links epithelial integrity and tumor suppression via regulation of myosin II and JNK signaling. [FBrf0214488] Kaplan et al., 2011, PLoS ONE 6(4): e18616 Complex Interactions between GSK3 and aPKC in Drosophila Embryonic Epithelial Morphogenesis. [FBrf0213424] Lanson et al., 2011, Hum. Mol. Genet. 20(13): 2510--2523 A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43. [FBrf0213887] Laplante and Nilson, 2011, J. Cell Biol. 192(2): 335--348 Asymmetric distribution of Echinoid defines the epidermal leading edge during Drosophila dorsal closure. [FBrf0212838] Lee and Thomas, 2011, Mech. Dev. 128(1-2): 116--128 Rac1 modulation of the apical domain is negatively regulated by β(Heavy)-spectrin. [FBrf0213021] Letizia et al., 2011, J. Cell Sci. 124(2): 240--251 Regulated Crb accumulation controls apical constriction and invagination in Drosophila tracheal cells. [FBrf0212559] Müller et al., 2011, Neuron 69(4): 749--762 Rab3-GAP Controls the Progression of Synaptic Homeostasis at a Late Stage of Vesicle Release. [FBrf0213055] Ohsawa et al., 2011, Dev. Cell 20(3): 315--328 Elimination of Oncogenic Neighbors by JNK-Mediated Engulfment in Drosophila. [FBrf0213219] Oshima and Fehon, 2011, J. Cell Sci. 124(16): 2861--2871 Analysis of protein dynamics within the septate junction reveals a highly stable core protein complex that does not include the basolateral polarity protein Discs large. [FBrf0214577] Park et al., 2011, Biochem. Biophys. Res. Commun. 404(2): 638--645 Normal prion protein in Drosophila enhances the toxicity of pathogenic polyglutamine proteins and alters susceptibility to oxidative and autophagy signaling modulators. [FBrf0212784] Raghu and Borst, 2011, PLoS ONE 6(5): e19472 Candidate glutamatergic neurons in the visual system of Drosophila. [FBrf0213690] Ribeiro et al., 2011, PLoS Genet. 7(2): e1001295 Phosphoinositide regulation of integrin trafficking required for muscle attachment and maintenance. [FBrf0213137] Rossetto et al., 2011, Hum. Mol. Genet. 20(21): 4248--4257 Defhc1.1, a homologue of the juvenile myoclonic gene EFHC1, modulates architecture and basal activity of the neuromuscular junction in Drosophila. [FBrf0216330] Shih and Chiang, 2011, J. Neurogenet. 25(1-2): 1--6 Anatomical Characterization of Thermosensory AC Neurons in the Adult Drosophila Brain. [FBrf0213700] Syed et al., 2011, J. Neurosci. 31(21): 7876--7885 The CD59 Family Member Leaky/Coiled Is Required for the Establishment of the Blood-Brain Barrier in Drosophila. [FBrf0213741] Szul et al., 2011, Cell. Logist. 1(2): 69--76 The Garz Sec7 domain guanine nucleotide exchange factor for Arf regulates salivary gland development in Drosophila. [FBrf0213963] Uytterhoeven et al., 2011, Cell 145(1): 117--132 Loss of skywalker reveals synaptic endosomes as sorting stations for synaptic vesicle proteins. [FBrf0213384] Varija Raghu et al., 2011, J. Comp. Neurol. 519(1): 162--176 Neurons with cholinergic phenotype in the visual system of Drosophila. [FBrf0212356] Wang et al., 2011, Dev. Biol. 350(2): 414--428 Notch signaling regulates neuroepithelial stem cell maintenance and neuroblast formation in Drosophila optic lobe development. [FBrf0212909] Willecke et al., 2011, Oncogene 30(39): 4067--4074 Loss of PI3K blocks cell-cycle progression in a Drosophila tumor model. [FBrf0216281] Wu et al., 2011, Curr. Biol. 21(10): 848--854 Heterotypic Gap Junctions between Two Neurons in the Drosophila Brain Are Critical for Memory. [FBrf0213804] Bachmann et al., 2010, J. Neurosci. 30(17): 5811--5824 A perisynaptic ménage à trois between Dlg, DLin-7, and Metro controls proper organization of Drosophila synaptic junctions. [FBrf0210640] Bahri et al., 2010, Development 137(12): 2023--2032 The leading edge during dorsal closure as a model for epithelial plasticity: Pak is required for recruitment of the Scribble complex and septate junction formation. [FBrf0210918] Ball et al., 2010, Neuron 66(4): 536--549 Retrograde BMP Signaling Controls Synaptic Growth at the NMJ by Regulating Trio Expression in Motor Neurons. [FBrf0210920] Banovic et al., 2010, Neuron 66(5): 724--738 Drosophila Neuroligin 1 Promotes Growth and Postsynaptic Differentiation at Glutamatergic Neuromuscular Junctions. [FBrf0211035] Beam and Moberg, 2010, Fly 4(2): 104--116 The gang of four gene regulates growth and patterning of the developing Drosophila eye. [FBrf0211089] Buchon et al., 2010, BMC Biol. 8: 152 Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection. [FBrf0212840] Cabernard et al., 2010, Nature 467(7311): 91--94 A spindle-independent cleavage furrow positioning pathway. [FBrf0211664] Campbell et al., 2010, Mech. Dev. 127(7-8): 345--357 Mesenchymal-to-epithelial transition of intercalating cells in Drosophila renal tubules depends on polarity cues from epithelial neighbours. [FBrf0211143] Chen et al., 2010, PLoS ONE 5(3): e9480 Role of Spastin in Apical Domain Control along the Rhabdomere Elongation in Drosophila Photoreceptor. [FBrf0210148] Choi et al., 2010, Hum. Mol. Genet. 19(22): 4474--4489 A Drosophila model of GSS syndrome suggests defects in active zones are responsible for pathogenesis of GSS syndrome. [FBrf0212151] Cordero et al., 2010, Dev. Cell 18(6): 999--1011 Oncogenic Ras diverts a host TNF tumor suppressor activity into tumor promoter. [FBrf0211264] Ekas et al., 2010, Dev. Biol. 344(2): 621--636 Characterization of a dominant-active STAT that promotes tumorigenesis in Drosophila. [FBrf0211400] Fan et al., 2010, Cell Death Differ. 17(6): 912--921 Dual roles of Drosophila p53 in cell death and cell differentiation. [FBrf0210741] Fernandes et al., 2010, Dev. Cell 18(1): 64--76 Zona pellucida domain proteins remodel the apical compartment for localized cell shape changes. [FBrf0211093] Fichelson et al., 2010, Development 137(5): 815--824 lethal giant larvae is required with the par genes for the early polarization of the Drosophila oocyte. [FBrf0209930] Forster et al., 2010, Curr. Biol. 20(1): 62--68 Sec24-Dependent Secretion Drives Cell-Autonomous Expansion of Tracheal Tubes in Drosophila. [FBrf0209657] Franz and Riechmann, 2010, Dev. Biol. 338(2): 136--147 Stepwise polarisation of the Drosophila follicular epithelium. [FBrf0209855] Garlena et al., 2010, J. Cell Sci. 123(18): 3177--3188 Regulation of mixed-lineage kinase activation in JNK-dependent morphogenesis. [FBrf0211702] Georgiou and Baum, 2010, J. Cell Sci. 123(7): 1089--1098 Polarity proteins and Rho GTPases cooperate to spatially organise epithelial actin-based protrusions. [FBrf0214990] Gervais and Casanova, 2010, Curr. Biol. 20(4): 359--366 In Vivo Coupling of Cell Elongation and Lumen Formation in a Single Cell. [FBrf0210105] Graham et al., 2010, J. Biol. Chem. 285(15): 11143--11153 Neurologic dysfunction and male infertility in Drosophila porin mutants: a new model for mitochondrial dysfunction and disease. [FBrf0210435] Grzeschik et al., 2010, Curr. Biol. 20(7): 573--581 Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms. [FBrf0210559] Haglund et al., 2010, Curr. Biol. 20(10): 944--950 Cindr interacts with anillin to control cytokinesis in Drosophila melanogaster. [FBrf0210868] Hamanaka and Meinertzhagen, 2010, J. Comp. Neurol. 518(7): 1133--1155 Immunocytochemical localization of synaptic proteins to photoreceptor synapses of Drosophila melanogaster. [FBrf0209968] Hamel et al., 2010, J. Cell Biol. 188(4): 581--594 Notch ligand activity is modulated by glycosphingolipid membrane composition in Drosophila melanogaster. [FBrf0210025] Harumoto et al., 2010, Dev. Cell 19(3): 389--401 Atypical cadherins dachsous and fat control dynamics of noncentrosomal microtubules in planar cell polarity. [FBrf0211754] Ho et al., 2010, Dev. Biol. 337(2): 274--283 Mob as tumor suppressor is activated at the cell membrane to control tissue growth and organ size in Drosophila. [FBrf0209794] Ho et al., 2010, Development 137(5): 745--754 Echinoid regulates Flamingo endocytosis to control ommatidial rotation in the Drosophila eye. [FBrf0209940] Januschke and Gonzalez, 2010, J. Cell Biol. 188(5): 693--706 The interphase microtubule aster is a determinant of asymmetric division orientation in Drosophila neuroblasts. [FBrf0210175] Kaplan and Tolwinski, 2010, J. Cell Sci. 123(18): 3157--3165 Spatially defined Dsh-Lgl interaction contributes to directional tissue morphogenesis. [FBrf0211705] Khuong et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(40): 17379--17384 WASP is activated by phosphatidylinositol-4,5-bisphosphate to restrict synapse growth in a pathway parallel to bone morphogenetic protein signaling. [FBrf0214154] Kim et al., 2010, J. Asia-Pacific Ent. 13(4): 339--343 Alterations in both acetylcholinesterase activity and synaptic scaffolding protein localization in the nervous system of Drosophila presenilin mutants. [FBrf0212161] Kim and Marqués, 2010, Dev. Dyn. 239(9): 2413--2425 Identification of downstream targets of the Bone Morphogenetic Protein pathway in the Drosophila nervous system. [FBrf0211763] Kitajima et al., 2010, Dev. Biol. 347(1): 9--23 Progenitor properties of symmetrically dividing Drosophila neuroblasts during embryonic and larval development. [FBrf0211968] Krahn et al., 2010, Curr. Biol. 20(7): 636--642 Membrane targeting of Bazooka/PAR-3 is mediated by direct binding to phosphoinositide lipids. [FBrf0210551] Laplante et al., 2010, Dev. Dyn. 239(9): 2509--2519 Echinoid regulates tracheal morphology and fusion cell fate in Drosophila. [FBrf0211771] Laprise et al., 2010, Curr. Biol. 20(1): 55--61 Epithelial Polarity Proteins Regulate Drosophila Tracheal Tube Size in Parallel to the Luminal Matrix Pathway. [FBrf0209969] Lee et al., 2010, J. Neurosci. 30(50): 16959--16969 LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction. [FBrf0212570] Lee and Wu, 2010, J. Neurosci. 30(47): 15821--15833 Orchestration of stepwise synaptic growth by k+ and Ca2+ channels in Drosophila. [FBrf0212405] Levine et al., 2010, Dev. Biol. 344(1): 196--209 Opposing interactions between Drosophila Cut and the C/EBP encoded by Slow Border Cells direct apical constriction and epithelial invagination. [FBrf0211314] Liu et al., 2010, J. Neurosci. 30(35): 11624--11634 Distinct Presynaptic and Postsynaptic Dismantling Processes of Drosophila Neuromuscular Junctions during Metamorphosis. [FBrf0211694] Marie et al., 2010, J. Neurosci. 30(24): 8071--8082 Synaptic homeostasis is consolidated by the cell fate gene gooseberry, a Drosophila pax3/7 homolog. [FBrf0211066] Masuda-Nakagawa et al., 2010, Gene Expr. Patterns 10(7-8): 328--337 Targeting expression to projection neurons that innervate specific mushroom body calyx and antennal lobe glomeruli in larval Drosophila. [FBrf0211879] Maurel-Zaffran et al., 2010, Dev. Biol. 343(1-2): 18--27 Reiterative use of signalling pathways controls multiple cellular events during Drosophila posterior spiracle organogenesis. [FBrf0211024] Maynard et al., 2010, Dev. Biol. 339(2): 295--306 Gp93, the Drosophila GRP94 ortholog, is required for gut epithelial homeostasis and nutrient assimilation-coupled growth control. [FBrf0210107] Milton et al., 2010, Development 137(5): 735--743 Differential requirement of Salvador-Warts-Hippo pathway members for organ size control in Drosophila melanogaster. [FBrf0209966] Morais-de-Sá et al., 2010, Cell 141(3): 509--523 aPKC phosphorylation of Bazooka defines the apical/lateral border in Drosophila epithelial cells. [FBrf0210663] Morimoto et al., 2010, Neuroscience 165(4): 1284--1292 Subunit-specific and homeostatic regulation of glutamate receptor localization by CaMKII in Drosophila neuromuscular junctions. [FBrf0209866] Mosca and Schwarz, 2010, Nat. Neurosci. 13(8): 935--943 The nuclear import of Frizzled2-C by Importins-beta11 and alpha2 promotes postsynaptic development. [FBrf0211361] Murthy et al., 2010, Development 137(16): 2773--2783 Sec5, a member of the exocyst complex, mediates Drosophila embryo cellularization. [FBrf0211434] Nahm et al., 2010, J. Neurosci. 30(24): 8138--8150 dCIP4 (Drosophila Cdc42-interacting protein 4) restrains synaptic growth by inhibiting the secretion of the retrograde Glass bottom boat signal. [FBrf0211075] Nelson et al., 2010, Genetics 185(3): 831--839 The Drosophila Claudin Kune-kune Is Required for Septate Junction Organization and Tracheal Tube Size Control. [FBrf0211332] Padash-Barmchi et al., 2010, J. Cell Sci. 123(23): 4052--4062 Control of Gliotactin localization and levels by tyrosine phosphorylation and endocytosis is necessary for survival of polarized epithelia. [FBrf0212409] Robinson et al., 2010, Curr. Biol. 20(7): 582--590 Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein expanded. [FBrf0210560] Rohrbough and Broadie, 2010, Development 137(20): 3523--3533 Anterograde Jelly belly ligand to Alk receptor signaling at developing synapses is regulated by Mind the gap. [FBrf0211915] Sekyrova et al., 2010, Development 137(1): 141--150 Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis. [FBrf0209550] Simone and DiNardo, 2010, Development 137(8): 1385--1394 Actomyosin contractility and Discs large contribute to junctional conversion in guiding cell alignment within the Drosophila embryonic epithelium. [FBrf0210407] Tamori et al., 2010, PLoS Biol. 8(7): e1000422 Involvement of Lgl and Mahjong/VprBP in Cell Competition. [FBrf0211298] Thomson and Johnson, 2010, Cell Death Differ. 17(11): 1717--1727 Inducible somatic oocyte destruction in response to rapamycin requires wild-type regulation of follicle cell epithelial polarity. [FBrf0211996] Tikhmyanova et al., 2010, PLoS ONE 5(8): e12369 Dcas supports cell polarization and cell-cell adhesion complexes in development. [FBrf0211678] Tsurudome et al., 2010, Neuron 68(5): 879--893 The Drosophila miR-310 Cluster Negatively Regulates Synaptic Strength at the Neuromuscular Junction. [FBrf0212495] Walther and Pichaud, 2010, Curr. Biol. 20(12): 1065--1074 Crumbs/DaPKC-Dependent Apical Exclusion of Bazooka Promotes Photoreceptor Polarity Remodeling. [FBrf0211169] Warner et al., 2010, Curr. Biol. 20(8): 677--686 The Cdc42/Par6/aPKC Polarity Complex Regulates Apoptosis-Induced Compensatory Proliferation in Epithelia. [FBrf0211164] Yu et al., 2010, Dev. Cell 18(2): 288--299 Kibra Functions as a Tumor Suppressor Protein that Regulates Hippo Signaling in Conjunction with Merlin and Expanded. [FBrf0210017] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...