eIF-4a, l(2)gdh-4, l(2L)162, deIF4A, l(2)k01501
Please see the JBrowse view of Dmel\eIF4A for information on other features
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Gene model reviewed during 5.55
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.44
1.9, 1.75 (northern blot)
2.2, 2.0 (northern blot)
402 (aa)
eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E1 and eIF4G1. Interacts with tud and vas.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\eIF4A using the Feature Mapper tool.
Comment: maternally deposited
eIF-4a transcripts are detected at all developmental stages. In embryos, they are already present in large amounts in fertilized eggs and are abundant in all tissues at later stages of development.
GBrowse - Visual display of RNA-Seq signals
View Dmel\eIF4A in GBrowse 22-18
2-18
2-19.2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
monoclonal
Source for identity of: eIF4A eIF-4a
Source for merge of: eIF-4a l(2)k01501
Source for merge of: eIF-4a Su(dpp)YE9
RNAi screen using dsRNA made from templates generated with primers directed against this gene results in aberrantly short, monopolar spindles when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.
S2 cells transfected with dsRNA made from templates generated with primers directed against this gene show significantly lower levels of global translation within 2 days.
RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.
Identification: identified in a genetic screen for suppressors of the dppH46 phenotype.
Identification: One of a collection of genes identified with defective larval growth that extend larval life.
Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland.
Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology.
A single copy gene.
1.6kb non-sex-specific transcript located close to Acp26Aa in the 26A region.