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Gene Dmel\eIF-4a

General Information
Symbol	Dmel\eIF-4a	Species	D. melanogaster
Name	Eukaryotic initiation factor 4a	Annotation symbol	CG9075
Feature type	protein_coding_gene	FlyBase ID	FBgn0001942
Gene Model Status	Current	Stock availability	19 publicly available
Also Known As	eIF4A, l(2L)162, l(2)gdh-4
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	26B2-26B2	Sequence location	2L:5,981,759..5,985,793 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Eukaryotic initiation factor 4a is referred to in FlyBase by the symbol Dmel\eIF-4a (CG9075, FBgn0001942). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: translation initiation factor activity; RNA helicase activity. There is experimental evidence that it is involved in the biological process: centrosome organization; germ-line stem cell maintenance; mitotic spindle elongation; response to DNA damage stimulus; mitosis; mitotic spindle organization; dorsal/ventral axis specification; oogenesis; female germ-line stem cell division; regulation of alternative nuclear mRNA splicing, via spliceosome. 67 alleles are reported. The phenotypes of these alleles are annotated with: multicellular structure; anatomical structure; organ system; cuticle; organ system subdivision; parasegment 9; dorsal thoracic disc; parasegment 14; parasegment 2; cephalopharyngeal skeleton; external compound sense organ; late extended germ band embryo. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: DEAD-like helicase; DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Helicase, C-terminal; RNA helicase, ATP-dependent, DEAD-box, conserved site; RNA helicase, DEAD-box type, Q motif. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very high expression. Peak expression observed within 00-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1638664_s_at completely aligns to an exonic region common to each of the 4 FlyBase-annotated transcript isoforms of eIF-4a. Gene sequence location is 2L:5981759..5985793.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	References Müller et al., 2010, EMBO J. 29(19): 3344--3357 Controlled Vocabulary Terms mitotic spindle centrosome organization centrosome Sequence features BKN27917 HFA03526 BKN46068
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 26B2-26B2   Limits computationally determined from genome sequence between P{EP}chicEP713&P{EP}chicEP1095 and P{lacW}Gef26k13720
Experimentally Determined Cytological Location
Cytogenetic map Notes References 25D5-26D1     (Li and Gelbart, 2002) 26B1-26B2   (determined by in situ hybridisation)   (Spradling et al., 1999) 26A5-26A7   26A5--8 26A7--8 26A7--9 26A8--9 26B1--2 26B8--9   (BDGP Project Members, 1994-1999) 26A7-26A9   (determined by in situ hybridisation) 27A7--27A9 (determined by in situ hybridisation)   (Dorn et al., 1993)
Experimentally Determined Recombination Data
Location
Left of (cM)	P{EP}CG13993EP570 P{EP}EP2273 P{lacW}l(2)k09923k09923 P{lacW}l(2)k09022k09022 P{lacW}hoipk07104 b P{lacW}l(2)k05404k05404 (Li et al., 2005)
Right of (cM)	P{lacW}vrik05901 P{EP}GpdhEP2304 P{lacW}l(2)k06502k06502 P{lacW}chick13321 dp (Li et al., 2005)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\eIF-4a for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) eIF-4a-RA FBtr0079175  NM_164668   1696   403 eIF-4a-RB FBtr0079177  NM_164669   1917   403 eIF-4a-RC FBtr0079176  NM_057247   1559   403 eIF-4a-RD FBtr0079178  NM_164670   1799   403 eIF-4a-RE FBtr0307068     1910   403
Additional Transcript Data & Comments
Reported size (kB)	2.2, 2.0 (northern blot) (Cooley et al., 1992) 1.9, 1.75 (northern blot) (Dorn et al., 1993)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein eIF-4a-PA   FBpp0078806   45.9   403   5.34     NP_723137   AAF52317 eIF-4a-PB   FBpp0078808   45.9   403   5.34     NP_723138   AAN10567 eIF-4a-PC   FBpp0078807   45.9   403   5.34     NP_476595   AAN10566 eIF-4a-PD   FBpp0078809   45.9   403   5.34     NP_723139   AAN10568 eIF-4a-PE   FBpp0297911   45.9   403   5.34
Additional Polypeptide Data & Comments
Reported size (kDa)	402 (aa) (Dorn et al., 1993)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • RNA helicase, ATP-dependent, DEAD-box, conserved site (IPR000629) Helicase, C-terminal (IPR001650) DNA/RNA helicase, DEAD/DEAH box type, N-terminal (IPR011545) DEAD-like helicase (IPR014001) RNA helicase, DEAD-box type, Q motif (IPR014014)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201849   AA201904   AA202043   AA202058   AA202343   AA202523   AA202707   AA202885   AA202911   AA246225   AA246437   AA246506   AA247040   AA263702   AA263703   AA263740   AA264124   AA264232   AA264404   AA264540   AA390312   AA390330   AA390395   AA390651   AA390892   AA390978   AA391457   AA391976   AA392388   AA392501   AA438988   AA439755   AA439819   AA440183   AA440525   AA440932   AA441300   AA538657   AA539088   AA539371   AA539422   AA540050   AA540710   AA540831   AA567273   AA567376   AA567552   AA694788   AA694826   AA695516   AA695987   AA696353   AA696408   AA696520   AA697086   AA697222   AA697323   AA697431   AA697788   AA697802   AA697804   AA697829   AA698722   AA698991   AA735106   AA735346   AA735456   AA735836   AA735931   AA736007   AA801530   AA801735   AA801806   AA801846   AA801924   AA801960   AA802051   AA802692   AA802790   AA802848   AA803048   AA803391   AA803571   AA803621   AA803725   AA803938   AA804095   AA816632   AA816793   AA817113   AA817502   AA817518   AA817542   AA817603   AA820066   AA820379   AA820516   AA820578   AA820735   AA820837   AA820989   AA821083   AA821157   AA940905   AA940910   AA941322   AA941530   AA941537   AA941629   AA941652   AA941803   AA941848   AA942119   AA942175   AA942326   AA942422   AA942582   AA948909   AA948954   AA949207   AA949330   AA949362   AA949550   AA950096   AA950102   AA950248   AA950323   AA950469   AA950703   AA950705   AA950774   AA950787   AA950815   AA950975   AA951108   AA951316   AA951420   AA951579   AA951658   AA952057   AA952062   AA952073   AA952180   AA952215   AA978383   AA979078   AA979291   AA979421   AA979461   AA979576   AA979694   AA990658   AA990687   AA990720   AE014134 AAF52317   AE014134 AAN10566   AE014134 AAN10567   AE014134 AAN10568   AC004268   AC004758   AC092216   AF145621   AI061704   AI061711   AI061915   AI062172   AI062369   AI063589   AI063841   AI063866   AI064029   AI064134   AI064322   AI064349   AI064634   AI107476   AI107807   AI107939   AI107944   AI108482   AI108985   AI109126   AI109343   AI109863   AI109899   AI110001   AI110016   AI110100   AI113781   AI134236   AI135016   AI135037   AI135038   AI135102   AI135217   AI135282   AI135503   AI135863   AI135955   AI238013   AI238055   AI238740   AI239195   AI239240   AI256904   AI256945   AI256947   AI257797   AI257865   AI258675   AI258902   AI259001   AI259182   AI259519   AI259537   AI259627   AI259684   AI259819   AI260946   AI292660   AI292899   AI293339   AI293345   AI294031   AI294586   AI294644   AI295007   AI295189   AI295330   AI295501   AI295739   AI296519   AI296528   AI296984   AI297611   AI297752   AI297758   AI297920   AI386609   AI386755   AI386793   AI387126   AI387256   AI387384   AI387459   AI387542   AI387908   AI388091   AI388308   AI388517   AI388566   AI389089   AI389161   AI389181   AI389768   AI390013   AI401935   AI402580   AI402648   AI402695   AI402788   AI402872   AI402881   AI403056   AI403613   AI403763   AI403767   AI403866   AI403937   AI404035   AI404185   AI404296   AI404631   AI404825   AI405088   AI405101   AI405121   AI405804   AI405984   AI455576   AI455692   AI455860   AI455900   AI455903   AI455946   AI456053   AI456121   AI456170   AI456256   AI456436   AI456542   AI456865   AI456992   AI511681   AI511720   AI511847   AI511854   AI511894   AI511916   AI511949   AI512336   AI513039   AI513172   AI513594   AI513827   AI513897   AI514346   AI514639   AI514658   AI514665   AI514820   AI514916   AI515014   AI515346   AI515439   AI515707   AI516090   AI516181   AI516208   AI516436   AI516586   AI516744   AI517545   AI517610   AI517656   AI517781   AI517937   AI518149   AI518156   AI518281   AI518553   AI518885   AI519083   AI519302   AI519304   AI519336   AI519603   AI519625   AI519662   AI519777   AI519858   AI519953   AI520072   AI520193   AI520401   AI520550   AI520607   AI530758   AI531392   AI532265   AI532352   AI533040   AI533082   AI533253   AI533477   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BI215294   BI216063   BI216233   BI227825   BI227972   BI228479   BI228847   BI229900   BI229930   BI230987   BI232064   BI234750   BI235330   BI235557   BI235732   BI237130   BI237440   BI237749   BI238307   BI240350   BI241263   BI241268   BI241763   BI243664   BI351654   BI353897   BI354228   BI354265   BI354319   BI354360   BI354363   BI354369   BI354379   BI354382   BI354396   BI355576   BI357181   BI358064   BI358135   BI358617   BI358622   BI358678   BI358682   BI358706   BI358710   BI358714   BI361873   BI362240   BI362292   BI363004   BI364133   BI364233   BI365815   BI366978   BI367464   BI371952   BI372414   BI372999   BI373536   BI373769   BI374556   BI374719   BI375195   BI375233   BI375401   BI483799   BI483819   BI485875   BI563541   BI564275   BI564326   BI564480   BI564558   BI564562   BI564738   BI565578   BI566135   BI566145   BI566240   BI566532   BI566659   BI566865   BI567443   BI567503   BI567693   BI567891   BI567907   BI567925   BI568140   BI568319   BI568335   BI568512   BI568690   BI568695   BI572198   BI572200   BI574324   BI574450   BI574754   BI574793   BI574923   BI574939   BI574969   BI574999   BI575860   BI576173   BI576364   BI576992   BI578703   BI582207   BI582209   BI582333   BI582381   BI582627   BI583042   BI583229   BI583969   BI584102   BI584216   BI584561   BI584647   BI584744   BI585897   BI586108   BI586175   BI586723   BI586832   BI587093   BI587707   BI587748   BI587886   BI587912   BI587929   BI588583   BI588988   BI589081   BI589189   BI589221   BI591144   BI591496   BI591706   BI592323   BI592346   BI592653   BI593241   BI604837   BI605145   BI605201   BI605207   BI605361   BI605512   BI605813   BI605884   BI606481   BI606726   BI607140   BI607236   BI607368   BI607561   BI607990   BI608288   BI608807   BI609232   BI610401   BI610431   BI610634   BI610659   BI610685   BI611136   BI611199   BI611538   BI611776   BI613088   BI613528   BI613840   BI613891   BI613916   BI614101   BI614226   BI614240   BI614291   BI614365   BI614383   BI615357   BI615713   BI615767   BI615866   BI615996   BI616679   BI617226   BI617802   BI618531   BI618656   BI619041   BI619122   BI619233   BI619550   BI619591   BI619866   BI620020   BI620283   BI620934   BI621166   BI621232   BI621714   BI621799   BI624220   BI624485   BI624542   BI624577   BI624583   BI624584   BI625255   BI625545   BI625688   BI625790   BI625809   BI625825   BI626113   BI626307   BI626761   BI627759   BI627989   BI628189   BI628301   BI628321   BI628969   BI629606   BI629687   BI629852   BI629911   BI630159   BI631290   BI631596   BI631606   BI631779   BI631787   BI632366   BI632492   BI632587   BI632603   BI632879   BI633043   BI633060   BI633181   BI633212   BI633432   BI633622   BI634043   BI634084   BI634094   BI634370   BI634571   BI634691   BI634698   BI634729   BI634766   BI634829   BI634970   BI635006   BI635184   BI636070   BI636220   BI636496   BI636811   BI637113   BI637124   BI637267   BI637292   BI637789   BI637891   BI638258   BI638348   BI639250   BI639421   BI639646   BI639750   BI640201   BI640474   BI640499   BI640539   BI640575   BI641106   BI641165   BI641233   BP540548   BP540549   BP541849   BP542219   BP542274   BP543180   BP543594   BP543595   BP545481   BP545482   BP547465   BP547827   BP547862   BP548040   BP548496   BP550187   BP550225   BP550226   BP551920   BP551921   BP552750   BP552751   BP554520   BP554521   BP554785   BP555793   BP557623   BP557624   BP558284   BP558285   BP558639   BP558640   BQ102860   BQ102959   BQ103082   BQ103234   BQ103367   BQ103658   BT099779   BT099924   BT120047   BX005606   BX005820   BX006051   BX006591   BX006799   BX006954   BX006999   BX007641   BX007972   BX008146   BX010574   BX011159   BX012073   BX012351   BX012571   BX013059   BX013936   BX014494   BX014549   BX014704   BX014949   BX016087   BX016259   BX016786   BX017198   BX018863   BX019527   BX019824   BX020351   BX020449   BX020719   BX020935   BX021157   BX022334   BX022395   BX022764   BX022817   BX023785   BX025017   BX025026   BX025155   BX025946   BX026426   BX026857   BX027281   BX027399   BX027600   BX027809   BX028052   BX028815   BX029055   BX029783   BX029860   BX029878   BX030041   BX031050   BX031808   BX032130   BX032923   BX033620   BX034342   BX034458   BX034606   BX036204   BX036646   BX036785   BX036939   BX037317   BX037323   BX039495   BX041311   BX041913   BX041931   BX042603   BX042800   BX043775   BX045526   BX045848   BX046370   BX046997   BX047008   BX048646   BX048874   BX051891   BX053902   BX054982   BX055207   BX056399   BX056578   BX056992   BX057121   BX057129   BX057996   BX059384   BX059457   BX059693   BX059729   BX060562   BX060628   BX060824   BX061963   BX062000   BX062173   BX063716   BX063776   BX064751   BX065077   BX065405   BX065543   BX068798   BX068965   BX069140   BX071670   BX071862   CA803673   CA803711   CA804164   CA804670   CA804776   CA805823   CA806990   CA807763   CA807851   CK086555   CK131608   CK131823   CK131832   CK131946   CK132065   CK132126   CK132140   CK132236   CK132397   CK656984   CK657116   CK657508   CK657740   CK658069   CK658151   CK658578   CK658689   CK659290   CK659438   CK659441   CK659473   CK659645   CK659801   CK660543   CK660632   CK660848   CK661153   CK661219   CK661335   CK662118   CO153226   CO153581   CO154146   CO154469   CO155359   CO155695   CO155882   CO156052   CO156827   CO178318   CO181582   CO182540   CO183143   CO190897   CO193681   CO264231   CO276050   CO281356   CO284683   CO285447   CO291865   CO303746   CO312873   CO316657   CO317991   CO318098   CO325793   CO326237   CO328058   CO328293   CO330756   CO332439   CO335710   CO335832   CO336026   CO336452   CO337129   CO337184   CO337285   CO338245   CO338821   CO339831   CZ475160   DN154319   DQ440212   EC055061   EC055108   EC055548   EC055963   EC060672   EC061120   EC061966   EC061983   EC063533   EC065075   EC069366   EC074092   EC074720   EC074937   EC081138   EC202290   EC204267   EC207036   EC213250   EC216352   EC221666   EC226134   EC239744   EC241307   EC242919   EC246947   EC250024   EC252877   EC258699   EC260222   EC260809   EC260880   EC261441   EC261519   EC261639   EC261827   EC263205   EC263361   EC263862   EC263904   EC263946   EC265726   EC266257   EC266328   EC266803   EC267728   EL870065   EL870066   EL871395   EL871396   EL873614   EL873615   EL873703   EL873811   EL873812   EL873910   EL876160   EL876161   EL876555   EL876776   EL877027   EL878970   EL878971   EL879041   EL879042   EL879072   EL879073   EL879112   EL879165   EL879166   EL879689   EL879810   EL879939   EL879940   EL880077   EL882137   EL882529   ES691485   ES691495   ES691518   ES691526   ES691952   ES691959   ES691961   ES692326   EU930205   EV576379   EV576870   EV578307   EV581477   EV586945   EV587577   EV588539   EV589324   EV591470   EV592870   EV593150   EV594274   EV595095   EV596328   EV599636   EV599780   EV600180   G01428   GH942141   GH946618   GH946666   GH947525   GH949374   GH949509   GH950629   GH951891   GH953036   GH954036   GH955175   GH955704   GH956556   GH958485   GH958521   GH959404   GH960460   GH961178   GH961550   GH963973   GH966052   GH966325   GH966535   GH968129   GH968162   GH968611   GH973214   GH974229   GH975361   GH975479   GH978909   GH980066   GH980980   GH981993   GH982092   GH982200   GH983388   X69045 CAA48790
UniProtKB/Swiss-Prot	Q02748
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | ubiquitous   (Dorn et al., 1993) embryonic stage -- adult stage     (Dorn et al., 1993)
Additional Descriptive Data
	eIF-4a transcripts are detected at all developmental stages. In embryos, they are already present in large amounts in fertilized eggs and are abundant in all tissues at later stages of development. (Dorn et al., 1993)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0001942    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0001942 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very high expression. Peak expression observed within 00-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0001942 expression level Developmental Stage   Expression Level embryo 00-02hr    72073 embryo 02-04hr    121488 embryo 04-06hr    134843 embryo 06-08hr    135861 embryo 08-10hr    143147 embryo 10-12hr    155102 embryo 12-14hr    91792 embryo 14-16hr    112783 embryo 16-18hr    99283 embryo 18-20hr    93920 embryo 20-22hr    97868 embryo 22-24hr    87983 larva L1    99720 larva L2    68893 larva L3 12hr old    58238 larva L3 puffstage 1-2    54204 larva L3 puffstage 3-6    64531 larva L3 puffstage 7-9    78732 white prepupae new    78556 white prepupae 12hr    88971 white prepupae 24hr    76742 pupae 2d postWPP    65658 pupae 3d postWPP    48194 pupae 4d postWPP    64553 adult male 01day    47341 adult male 05day    51427 adult male 30day    54747 adult female 01day    80642 adult female 05day    64720 adult female 30day    68050 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (72073) embryo 02-04hr  (121488) embryo 04-06hr  (134843) embryo 06-08hr  (135861) embryo 08-10hr  (143147) embryo 10-12hr  (155102) embryo 12-14hr  (91792) embryo 14-16hr  (112783) embryo 16-18hr  (99283) embryo 18-20hr  (93920) embryo 20-22hr  (97868) embryo 22-24hr  (87983) larva L1  (99720) larva L2  (68893) larva L3 12hr old  (58238) larva L3 puffstage 1-2  (54204) larva L3 puffstage 3-6  (64531) larva L3 puffstage 7-9  (78732) white prepupae new  (78556) white prepupae 12hr  (88971) white prepupae 24hr  (76742) pupae 2d postWPP  (65658) pupae 3d postWPP  (48194) pupae 4d postWPP  (64553) adult male 01day  (47341) adult male 05day  (51427) adult male 30day  (54747) adult female 01day  (80642) adult female 05day  (64720) adult female 30day  (68050) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (72073) embryo 02-04hr  (121488) embryo 04-06hr  (134843) embryo 06-08hr  (135861) embryo 08-10hr  (143147) embryo 10-12hr  (155102) embryo 12-14hr  (91792) embryo 14-16hr  (112783) embryo 16-18hr  (99283) embryo 18-20hr  (93920) embryo 20-22hr  (97868) embryo 22-24hr  (87983) larva L1  (99720) larva L2  (68893) larva L3 12hr old  (58238) larva L3 puffstage 1-2  (54204) larva L3 puffstage 3-6  (64531) larva L3 puffstage 7-9  (78732) white prepupae new  (78556) white prepupae 12hr  (88971) white prepupae 24hr  (76742) pupae 2d postWPP  (65658) pupae 3d postWPP  (48194) pupae 4d postWPP  (64553) adult male 01day  (47341) adult male 05day  (51427) adult male 30day  (54747) adult female 01day  (80642) adult female 05day  (64720) adult female 30day  (68050) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (72073) embryo 02-04hr  (121488) embryo 04-06hr  (134843) embryo 06-08hr  (135861) embryo 08-10hr  (143147) embryo 10-12hr  (155102) embryo 12-14hr  (91792) embryo 14-16hr  (112783) embryo 16-18hr  (99283) embryo 18-20hr  (93920) embryo 20-22hr  (97868) embryo 22-24hr  (87983) larva L1  (99720) larva L2  (68893) larva L3 12hr old  (58238) larva L3 puffstage 1-2  (54204) larva L3 puffstage 3-6  (64531) larva L3 puffstage 7-9  (78732) white prepupae new  (78556) white prepupae 12hr  (88971) white prepupae 24hr  (76742) pupae 2d postWPP  (65658) pupae 3d postWPP  (48194) pupae 4d postWPP  (64553) adult male 01day  (47341) adult male 05day  (51427) adult male 30day  (54747) adult female 01day  (80642) adult female 05day  (64720) adult female 30day  (68050) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    72073 embryo 02-04hr    121488 embryo 04-06hr    134843 embryo 06-08hr    135861 embryo 08-10hr    143147 embryo 10-12hr    155102 embryo 12-14hr    91792 embryo 14-16hr    112783 embryo 16-18hr    99283 embryo 18-20hr    93920 embryo 20-22hr    97868 embryo 22-24hr    87983 larva L1    99720 larva L2    68893 larva L3 12hr old    58238 larva L3 puffstage 1-2    54204 larva L3 puffstage 3-6    64531 larva L3 puffstage 7-9    78732 white prepupae new    78556 white prepupae 12hr    88971 white prepupae 24hr    76742 pupae 2d postWPP    65658 pupae 3d postWPP    48194 pupae 4d postWPP    64553 adult male 01day    47341 adult male 05day    51427 adult male 30day    54747 adult female 01day    80642 adult female 05day    64720 adult female 30day    68050 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0001942 expression level Developmental Stage   Expression Level embryo 00-02hr    72073 embryo 02-04hr    121488 embryo 04-06hr    134843 embryo 06-08hr    135861 embryo 08-10hr    143147 embryo 10-12hr    155102 embryo 12-14hr    91792 embryo 14-16hr    112783 embryo 16-18hr    99283 embryo 18-20hr    93920 embryo 20-22hr    97868 embryo 22-24hr    87983 larva L1    99720 larva L2    68893 larva L3 12hr old    58238 larva L3 puffstage 1-2    54204 larva L3 puffstage 3-6    64531 larva L3 puffstage 7-9    78732 white prepupae new    78556 white prepupae 12hr    88971 white prepupae 24hr    76742 pupae 2d postWPP    65658 pupae 3d postWPP    48194 pupae 4d postWPP    64553 adult male 01day    47341 adult male 05day    51427 adult male 30day    54747 adult female 01day    80642 adult female 05day    64720 adult female 30day    68050 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (72073) embryo 02-04hr  (121488) embryo 04-06hr  (134843) embryo 06-08hr  (135861) embryo 08-10hr  (143147) embryo 10-12hr  (155102) embryo 12-14hr  (91792) embryo 14-16hr  (112783) embryo 16-18hr  (99283) embryo 18-20hr  (93920) embryo 20-22hr  (97868) embryo 22-24hr  (87983) larva L1  (99720) larva L2  (68893) larva L3 12hr old  (58238) larva L3 puffstage 1-2  (54204) larva L3 puffstage 3-6  (64531) larva L3 puffstage 7-9  (78732) white prepupae new  (78556) white prepupae 12hr  (88971) white prepupae 24hr  (76742) pupae 2d postWPP  (65658) pupae 3d postWPP  (48194) pupae 4d postWPP  (64553) adult male 01day  (47341) adult male 05day  (51427) adult male 30day  (54747) adult female 01day  (80642) adult female 05day  (64720) adult female 30day  (68050) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (72073) embryo 02-04hr  (121488) embryo 04-06hr  (134843) embryo 06-08hr  (135861) embryo 08-10hr  (143147) embryo 10-12hr  (155102) embryo 12-14hr  (91792) embryo 14-16hr  (112783) embryo 16-18hr  (99283) embryo 18-20hr  (93920) embryo 20-22hr  (97868) embryo 22-24hr  (87983) larva L1  (99720) larva L2  (68893) larva L3 12hr old  (58238) larva L3 puffstage 1-2  (54204) larva L3 puffstage 3-6  (64531) larva L3 puffstage 7-9  (78732) white prepupae new  (78556) white prepupae 12hr  (88971) white prepupae 24hr  (76742) pupae 2d postWPP  (65658) pupae 3d postWPP  (48194) pupae 4d postWPP  (64553) adult male 01day  (47341) adult male 05day  (51427) adult male 30day  (54747) adult female 01day  (80642) adult female 05day  (64720) adult female 30day  (68050) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (72073) embryo 02-04hr  (121488) embryo 04-06hr  (134843) embryo 06-08hr  (135861) embryo 08-10hr  (143147) embryo 10-12hr  (155102) embryo 12-14hr  (91792) embryo 14-16hr  (112783) embryo 16-18hr  (99283) embryo 18-20hr  (93920) embryo 20-22hr  (97868) embryo 22-24hr  (87983) larva L1  (99720) larva L2  (68893) larva L3 12hr old  (58238) larva L3 puffstage 1-2  (54204) larva L3 puffstage 3-6  (64531) larva L3 puffstage 7-9  (78732) white prepupae new  (78556) white prepupae 12hr  (88971) white prepupae 24hr  (76742) pupae 2d postWPP  (65658) pupae 3d postWPP  (48194) pupae 4d postWPP  (64553) adult male 01day  (47341) adult male 05day  (51427) adult male 30day  (54747) adult female 01day  (80642) adult female 05day  (64720) adult female 30day  (68050) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    72073 embryo 02-04hr    121488 embryo 04-06hr    134843 embryo 06-08hr    135861 embryo 08-10hr    143147 embryo 10-12hr    155102 embryo 12-14hr    91792 embryo 14-16hr    112783 embryo 16-18hr    99283 embryo 18-20hr    93920 embryo 20-22hr    97868 embryo 22-24hr    87983 larva L1    99720 larva L2    68893 larva L3 12hr old    58238 larva L3 puffstage 1-2    54204 larva L3 puffstage 3-6    64531 larva L3 puffstage 7-9    78732 white prepupae new    78556 white prepupae 12hr    88971 white prepupae 24hr    76742 pupae 2d postWPP    65658 pupae 3d postWPP    48194 pupae 4d postWPP    64553 adult male 01day    47341 adult male 05day    51427 adult male 30day    54747 adult female 01day    80642 adult female 05day    64720 adult female 30day    68050 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0001942    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0001942 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0001942 expression level Tissue   Expression Level Larval Central Nervous System    2615.7 Larval Midgut    3780.1 Larval Hindgut    3810.4 Larval Malpighian Tubules    4102.7 Larval Fat Body    5477.5 Larval Salivary Gland    6080.1 Larval Trachea    3528 Larval Carcass    3864.55 Adult Head    3607.8 Adult Eye    4196.025 Adult Brain    3005.3 Adult Thoracic-Abdominal Ganglion    3503.8 Adult Crop    3985.6 Adult Midgut    3541.4 Adult Hindgut    3746 Adult Malpighian Tubules    4480.9 Adult Fat Body    4964.1 Adult Salivary Gland    7727.6 Adult Heart    4465.3 Adult VirginFemale Spermatheca    4423.2 Adult InseminatedFemale Spermatheca    4488.3 Adult Ovary    2631.7 Adult Testis    1529 Adult Male Accessory Gland    6215 Adult Carcass    4088.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2615.7) Larval Midgut  (3780.1) Larval Hindgut  (3810.4) Larval Malpighian Tubules  (4102.7) Larval Fat Body  (5477.5) Larval Salivary Gland  (6080.1) Larval Trachea  (3528) Larval Carcass  (3864.55) Adult Head  (3607.8) Adult Eye  (4196.025) Adult Brain  (3005.3) Adult Thoracic-Abdominal Ganglion  (3503.8) Adult Crop  (3985.6) Adult Midgut  (3541.4) Adult Hindgut  (3746) Adult Malpighian Tubules  (4480.9) Adult Fat Body  (4964.1) Adult Salivary Gland  (7727.6) Adult Heart  (4465.3) Adult VirginFemale Spermatheca  (4423.2) Adult InseminatedFemale Spermatheca  (4488.3) Adult Ovary  (2631.7) Adult Testis  (1529) Adult Male Accessory Gland  (6215) Adult Carcass  (4088.3) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2615.7) Larval Midgut  (3780.1) Larval Hindgut  (3810.4) Larval Malpighian Tubules  (4102.7) Larval Fat Body  (5477.5) Larval Salivary Gland  (6080.1) Larval Trachea  (3528) Larval Carcass  (3864.55) Adult Head  (3607.8) Adult Eye  (4196.025) Adult Brain  (3005.3) Adult Thoracic-Abdominal Ganglion  (3503.8) Adult Crop  (3985.6) Adult Midgut  (3541.4) Adult Hindgut  (3746) Adult Malpighian Tubules  (4480.9) Adult Fat Body  (4964.1) Adult Salivary Gland  (7727.6) Adult Heart  (4465.3) Adult VirginFemale Spermatheca  (4423.2) Adult InseminatedFemale Spermatheca  (4488.3) Adult Ovary  (2631.7) Adult Testis  (1529) Adult Male Accessory Gland  (6215) Adult Carcass  (4088.3) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2615.7 Larval Midgut    3780.1 Larval Hindgut    3810.4 Larval Malpighian Tubules    4102.7 Larval Fat Body    5477.5 Larval Salivary Gland    6080.1 Larval Trachea    3528 Larval Carcass    3864.55 Adult Head    3607.8 Adult Eye    4196.025 Adult Brain    3005.3 Adult Thoracic-Abdominal Ganglion    3503.8 Adult Crop    3985.6 Adult Midgut    3541.4 Adult Hindgut    3746 Adult Malpighian Tubules    4480.9 Adult Fat Body    4964.1 Adult Salivary Gland    7727.6 Adult Heart    4465.3 Adult VirginFemale Spermatheca    4423.2 Adult InseminatedFemale Spermatheca    4488.3 Adult Ovary    2631.7 Adult Testis    1529 Adult Male Accessory Gland    6215 Adult Carcass    4088.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0001942 expression level Tissue   Expression Level Larval Central Nervous System    2615.7 Larval Midgut    3780.1 Larval Hindgut    3810.4 Larval Malpighian Tubules    4102.7 Larval Fat Body    5477.5 Larval Salivary Gland    6080.1 Larval Trachea    3528 Larval Carcass    3864.55 Adult Head    3607.8 Adult Eye    4196.025 Adult Brain    3005.3 Adult Thoracic-Abdominal Ganglion    3503.8 Adult Crop    3985.6 Adult Midgut    3541.4 Adult Hindgut    3746 Adult Malpighian Tubules    4480.9 Adult Fat Body    4964.1 Adult Salivary Gland    7727.6 Adult Heart    4465.3 Adult VirginFemale Spermatheca    4423.2 Adult InseminatedFemale Spermatheca    4488.3 Adult Ovary    2631.7 Adult Testis    1529 Adult Male Accessory Gland    6215 Adult Carcass    4088.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2615.7) Larval Midgut  (3780.1) Larval Hindgut  (3810.4) Larval Malpighian Tubules  (4102.7) Larval Fat Body  (5477.5) Larval Salivary Gland  (6080.1) Larval Trachea  (3528) Larval Carcass  (3864.55) Adult Head  (3607.8) Adult Eye  (4196.025) Adult Brain  (3005.3) Adult Thoracic-Abdominal Ganglion  (3503.8) Adult Crop  (3985.6) Adult Midgut  (3541.4) Adult Hindgut  (3746) Adult Malpighian Tubules  (4480.9) Adult Fat Body  (4964.1) Adult Salivary Gland  (7727.6) Adult Heart  (4465.3) Adult VirginFemale Spermatheca  (4423.2) Adult InseminatedFemale Spermatheca  (4488.3) Adult Ovary  (2631.7) Adult Testis  (1529) Adult Male Accessory Gland  (6215) Adult Carcass  (4088.3) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2615.7) Larval Midgut  (3780.1) Larval Hindgut  (3810.4) Larval Malpighian Tubules  (4102.7) Larval Fat Body  (5477.5) Larval Salivary Gland  (6080.1) Larval Trachea  (3528) Larval Carcass  (3864.55) Adult Head  (3607.8) Adult Eye  (4196.025) Adult Brain  (3005.3) Adult Thoracic-Abdominal Ganglion  (3503.8) Adult Crop  (3985.6) Adult Midgut  (3541.4) Adult Hindgut  (3746) Adult Malpighian Tubules  (4480.9) Adult Fat Body  (4964.1) Adult Salivary Gland  (7727.6) Adult Heart  (4465.3) Adult VirginFemale Spermatheca  (4423.2) Adult InseminatedFemale Spermatheca  (4488.3) Adult Ovary  (2631.7) Adult Testis  1529 Adult Male Accessory Gland  (6215) Adult Carcass  (4088.3) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2615.7 Larval Midgut    3780.1 Larval Hindgut    3810.4 Larval Malpighian Tubules    4102.7 Larval Fat Body    5477.5 Larval Salivary Gland    6080.1 Larval Trachea    3528 Larval Carcass    3864.55 Adult Head    3607.8 Adult Eye    4196.025 Adult Brain    3005.3 Adult Thoracic-Abdominal Ganglion    3503.8 Adult Crop    3985.6 Adult Midgut    3541.4 Adult Hindgut    3746 Adult Malpighian Tubules    4480.9 Adult Fat Body    4964.1 Adult Salivary Gland    7727.6 Adult Heart    4465.3 Adult VirginFemale Spermatheca    4423.2 Adult InseminatedFemale Spermatheca    4488.3 Adult Ovary    2631.7 Adult Testis    1529 Adult Male Accessory Gland    6215 Adult Carcass    4088.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    3607.8   NA  Eye    4196.025   NA  Brain    3005.3   2615.7  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    3503.8   NA  Crop    3985.6   3780.1  Midgut    3541.4   3810.4  Hindgut    3746   4102.7  Malpighian Tubules    4480.9   5477.5  Fat Body    4964.1   6080.1  Salivary Gland    7727.6   NA  Heart    4465.3   3528  Trachea    NA   NA  VirginFemale Spermatheca    4423.2   NA  InseminatedFemale Spermatheca    4488.3   NA  Ovary    2631.7   NA  Testis    1529   NA  Male Accessory Gland    6215   3864.55  Carcass    4088.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_31
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001942 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9075-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal eIF-4aCB03721 lethal, with Scer\GAL4pnr-MD237 eIF-4aGD14111 lethal (with Df(2L)GpdhA) eIF-4aYE9 lethal | embryonic stage (with Df(2L)E110) eIF-4aYE9 lethal | embryonic stage | recessive eIF-4aYE9 lethal | first instar larval stage (with Df(2L)E110) eIF-4aYE9 lethal | first instar larval stage (with eIF-4a02439) eIF-4aYE9 lethal | first instar larval stage (with eIF-4aYE9) eIF-4a02439 lethal | larval stage | recessive eIF-4a162-3 eIF-4a1006 eIF-4a1013 eIF-4a1069 eIF-4a02439 eIF-4ak14518 eIF-4ak14610 eIF-4ak15403 lethal | pupal stage, with Scer\GAL4pnr-MD237 eIF-4aGD14111 lethal | recessive eIF-4a1-9 eIF-4a26Ac-1 eIF-4a26Ac-2 eIF-4a26Ac-3 eIF-4a162-3 eIF-4a162-5 eIF-4a162-7 eIF-4a162-8 eIF-4a162-18 eIF-4a162-R36 eIF-4a162-R39 eIF-4a162-R59 eIF-4a02439 eIF-4a02623 eIF-4a06689 eIF-4aDS-16 eIF-4ak01501 eIF-4ak01801 eIF-4ak05206 eIF-4ak07120 eIF-4ak07519 eIF-4ak08101 eIF-4ak08109 eIF-4ak08120 eIF-4ak09234 eIF-4ak09319a eIF-4aPN-1 eIF-4aPN-8 lethal | second instar larval stage (with Df(2L)E110) eIF-4a02439 lethal | second instar larval stage (with eIF-4a02439) eIF-4aYE9 lethal | second instar larval stage (with eIF-4aYE9) eIF-4a02439 lethal | third instar larval stage (with Df(2L)E110) eIF-4a02439 semi-lethal | recessive eIF-4a162-R1 eIF-4a162-R30 eIF-4a162-R35 eIF-4a162-R75 Other Phenotypes Allele decreased cell number | germline clone eIF-4a1006 developmental rate defective | dominant | larval stage eIF-4aYE9 mitotic cell cycle defective | recessive eIF-4a1006 eIF-4a1013 eIF-4a1069 eIF-4ak14518 eIF-4ak14610 eIF-4ak15403 neuroanatomy defective, with Scer\GAL4elav-C155 eIF-4aEP1011 Phenotype manifest in Allele amnioserosa eIF-4a1006 eIF-4aYE9 amnioserosa (with Df(2L)GpdhA) eIF-4a1006 anterior fascicle & synapse, with Scer\GAL4elav-C155 eIF-4aEP1011 cephalopharyngeal skeleton eIF-4aYE9 cuticle eIF-4a162-18 eIF-4a162-5 eIF-4a162-7 eIF-4a162-8 embryonic/first instar larval cuticle eIF-4aYE9 eye eIF-4a1006 eIF-4a1013 female germline stem cell | germline clone eIF-4a1006 eIF-4a1013 eIF-4ak01501 head eIF-4a162-18 eIF-4a162-5 eIF-4a162-7 eIF-4a162-8 intersegmental nerve, with Scer\GAL4elav-C155 eIF-4aEP1011 parasegment 1 eIF-4a162-18 eIF-4a162-5 eIF-4a162-7 eIF-4a162-8 parasegment 2 eIF-4a162-18 eIF-4a162-5 eIF-4a162-7 eIF-4a162-8 parasegment 3 eIF-4a162-18 eIF-4a162-5 eIF-4a162-7 eIF-4a162-8 parasegment 4 eIF-4a162-18 eIF-4a162-5 eIF-4a162-7 eIF-4a162-8 parasegment 5 eIF-4a162-18 eIF-4a162-5 eIF-4a162-7 eIF-4a162-8 parasegment 6 eIF-4a162-18 eIF-4a162-5 eIF-4a162-7 eIF-4a162-8 parasegment 7 eIF-4a162-18 eIF-4a162-5 eIF-4a162-7 eIF-4a162-8 parasegment 8 eIF-4a162-18 eIF-4a162-5 eIF-4a162-7 eIF-4a162-8 parasegment 9 eIF-4a162-18 eIF-4a162-5 eIF-4a162-7 eIF-4a162-8 parasegment 10 eIF-4a162-18 eIF-4a162-5 eIF-4a162-7 eIF-4a162-8 parasegment 11 eIF-4a162-18 eIF-4a162-5 eIF-4a162-7 eIF-4a162-8 parasegment 12 eIF-4a162-18 eIF-4a162-5 eIF-4a162-7 eIF-4a162-8 parasegment 13 eIF-4a162-18 eIF-4a162-5 eIF-4a162-7 eIF-4a162-8 parasegment 14 eIF-4a162-18 eIF-4a162-5 eIF-4a162-7 eIF-4a162-8 parasegment 15 eIF-4a162-18 eIF-4a162-5 eIF-4a162-7 eIF-4a162-8 wing disc eIF-4a1006 eIF-4a1013 eIF-4a1069 eIF-4a162-3
Classical Alleles ( 61 )
For All Classical Alleles Show
Allele of eIF-4a Class Mutagen Stocks Known lesion eIF-4ak01501 P-element activity 2 Yes eIF-4aNP1272 2 -- eIF-4a02439 P-element activity 1 -- eIF-4a1013 P-element activity 1 Yes eIF-4a5-HA-1998 1 -- eIF-4aCB-0582-3 1 -- eIF-4aCB-0707-3 1 -- eIF-4ad06487 P-element activity 1 -- eIF-4ak01801 P-element activity 1 -- eIF-4ak07120 P-element activity 1 -- eIF-4ak14518 P-element activity 1 -- eIF-4aNP6380 1 -- eIF-4aUM-8048-3 1 -- eIF-4a02623 P-element activity 0 -- eIF-4a06689 P-element activity 0 -- eIF-4a09A09 0 Yes eIF-4a1-9 ethyl methanesulfonate 0 -- eIF-4a1006 P-element activity 0 Yes eIF-4a1069 P-element activity 0 Yes eIF-4a10A07 0 Yes eIF-4a10A12 0 Yes eIF-4a162-18 X ray 0 Yes eIF-4a162-3 P-element activity 0 Yes eIF-4a162-5 X ray 0 Yes eIF-4a162-7 X ray 0 Yes eIF-4a162-8 X ray 0 Yes eIF-4a162-R1 Delta2-3 0 Yes eIF-4a162-R30 Delta2-3 0 Yes eIF-4a162-R35 Delta2-3 0 Yes eIF-4a162-R36 Delta2-3 0 Yes eIF-4a162-R39 Delta2-3 0 Yes eIF-4a162-R59 Delta2-3 0 Yes eIF-4a162-R75 Delta2-3 0 Yes eIF-4a24A03 0 Yes eIF-4a26Ac-1 ethyl methanesulfonate 0 -- eIF-4a26Ac-2 ethyl methanesulfonate 0 -- eIF-4a26Ac-3 ethyl methanesulfonate 0 -- eIF-4aCB03721 P-element activity 0 Yes eIF-4aDS-16 ethyl methanesulfonate 0 -- eIF-4aEP1011 P-element activity 0 Yes eIF-4aEP2078 P-element activity 0 -- eIF-4aEP2166 P-element activity 0 -- eIF-4aG29 P-element activity 0 -- eIF-4aGS-A2207 Delta2-3 0 -- eIF-4ak05206 P-element activity 0 -- eIF-4ak07218 0 -- eIF-4ak07519 P-element activity 0 -- eIF-4ak08101 P-element activity 0 -- eIF-4ak08109 P-element activity 0 -- eIF-4ak08120 P-element activity 0 -- eIF-4ak09234 P-element activity 0 -- eIF-4ak09319a P-element activity 0 -- eIF-4ak09406 P-element activity 0 -- eIF-4ak14610 P-element activity 0 -- eIF-4ak15403 0 -- eIF-4ak16006 0 -- eIF-4ak16010 0 -- eIF-4aPN-1 ethyl methanesulfonate 0 -- eIF-4aPN-8 ethyl methanesulfonate 0 -- eIF-4aunspecified 0 -- eIF-4aYE9 antimorphic allele - genetic evidence ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of eIF-4a Class Mutagen Stocks Known lesion eIF-4aGD14111 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes eIF-4aHMS00927 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes eIF-4aKK107917 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes eIF-4aR321H.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes eIF-4aScer\UAS.cLa in vitro construct - regulatory fusion 0 Yes eIF-4aScer\UAS.P\T.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)BSC184 (Christensen and Cook, 2006.8.29) Df(2L)chic-106 (Verheyen and Cooley, 1994) Df(2L)chic-112 (Verheyen and Cooley, 1994) Df(2L)chic-129 (Verheyen and Cooley, 1994) Df(2L)chic38 (Verheyen and Cooley, 1994) Df(2L)chic103 (Verheyen and Cooley, 1994) Df(2L)chic139 (Verheyen and Cooley, 1994) Df(2L)cl-h3 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2L)E110 (Spradling et al., 1999, Li et al., 2005, BDGP Project Members, 1994-1999) Df(2L)Exel8017 (Ryder, 2004.4.26) Df(2L)GpdhA (Spradling et al., 1999, Li et al., 2005, Kotarski et al., 1983, Dorn et al., 1993, BDGP Project Members, 1994-1999, Beaton, 1997.3.4) Ts(YLt;2Lt)H69+Ts(YLt;2Rt)D211 (Kotarski et al., 1983)
Not disrupted in	Df(2L)2802 (Kotarski et al., 1983) Df(2L)ade2-3 (BDGP Project Members, 1994-1999) Df(2L)cl1 (Kotarski et al., 1983) Df(2L)cl2 (Kotarski et al., 1983) Df(2L)cl7 (Kotarski et al., 1983, Dorn et al., 1993) Df(2L)Gpdh75 (Kotarski et al., 1983) Df(2L)Gpdh78 (Kotarski et al., 1983) Df(2L)TW161 (BDGP Project Members, 1994-1999) Df(2R)M60E (BDGP Project Members, 1994-1999) Df(2R)Np3 (BDGP Project Members, 1994-1999) Df(2R)Np5 (BDGP Project Members, 1994-1999) Df(2R)Pu-D17 (BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD14111} NA P{KK107917} NA P{TRiP.HMS00927} NA P{UAS-eIF-4a.L} NA P{UAS-eIF-4a.MYC} NA P{UAS-eIF-4a.R321H} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}eIF-4a1006 No P{lacW}eIF-4a1013 No P{lacW}eIF-4a1069 No P{lacW}eIF-4ak01501 No P{lacW}eIF-4ak01801 No P{lacW}eIF-4ak05206 No P{lacW}eIF-4ak07120 No P{lacW}eIF-4ak07519 No P{lacW}eIF-4ak08101 No P{lacW}eIF-4ak08109 No P{lacW}eIF-4ak08120 No P{lacW}eIF-4ak09234 No P{lacW}eIF-4ak09319a No P{lacW}eIF-4ak09406 No P{lacW}eIF-4ak14518 No P{lacW}eIF-4ak14610 No P{lacW}l(2)SH2226SH2226 No P{PZ}eIF-4a02439 No P{PZ}eIF-4a02623 No P{PZ}eIF-4a06689 No insertion of mobile activating element P{EP}eIF-4aEP1011 NA P{EP}eIF-4aEP2078 NA P{EP}eIF-4aEP2166 NA P{GSV1}C174C174 NA P{GSV1}eIF-4aGS-A2207 NA P{XP}eIF-4ad06487 NA miscellaneous insertions P{?hsneo.ry+}eIF-4a162-R1 NA P{?hsneo.ry+}eIF-4a162-R30 NA P{?hsneo.ry+}eIF-4a162-R35 NA P{?hsneo.ry+}eIF-4a162-R36 NA P{?hsneo.ry+}eIF-4a162-R39 NA P{?hsneo.ry+}eIF-4a162-R59 NA P{?hsneo.ry+}eIF-4a162-R75 NA P{hsneo.ry+}eIF-4a162-3 NA P{PTT-GB}eIF-4aCB03721 NA P{PTT-un1}eIF-4aG29 NA P{RS3}eIF-4aCB-0582-3 NA P{RS3}eIF-4aCB-0707-3 NA P{RS3}eIF-4aUM-8048-3 NA P{RS5}eIF-4a5-HA-1998 NA P{wHy}eIF-4a09A09 NA P{wHy}eIF-4a10A07 NA P{wHy}eIF-4a10A12 NA P{wHy}eIF-4a24A03 NA insertion of enhancer trap binary system P{GawB}eIF-4aNP1272 No P{GawB}eIF-4aNP6380 No
Gene Ontology: Function, Process & Cellular Component ( 27 unique terms )
Terms Based on Experimental Evidence ( 13 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
centrosome organization inferred from mutant phenotype (Müller et al., 2010) dorsal/ventral axis specification inferred from mutant phenotype (Li and Gelbart, 2002) female germ-line stem cell division inferred from genetic interaction with bam (Shen et al., 2009) inferred from mutant phenotype (Shen et al., 2009) germ-line stem cell maintenance inferred from mutant phenotype (Shen et al., 2009) mitosis inferred from mutant phenotype (Ducat et al., 2008) mitotic spindle elongation inferred from mutant phenotype (Goshima et al., 2007) mitotic spindle organization inferred from mutant phenotype (Goshima et al., 2007) oogenesis inferred from genetic interaction with bam (Shen et al., 2009) regulation of alternative nuclear mRNA splicing, via spliceosome inferred from mutant phenotype (Park et al., 2004, Katzenberger et al., 2009) response to DNA damage stimulus inferred from mutant phenotype (Ravi et al., 2009)
Cellular Component
CV term Evidence References
centrosome inferred from direct assay (Müller et al., 2010) microtubule associated complex inferred from direct assay (Hughes et al., 2008) mitotic spindle inferred from direct assay (Müller et al., 2010)
Terms Based on Predictions or Assertions ( 14 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000629, InterPro:IPR001650, InterPro:IPR011545 (FlyBase Curators et al., 2004-) ATP-dependent helicase activity inferred from electronic annotation with InterPro:IPR000629, InterPro:IPR011545 (FlyBase Curators et al., 2004-) mRNA binding non-traceable author statement (Swiss-Prot Project Members, 1993.7.1) RNA cap binding non-traceable author statement (Swiss-Prot Project Members, 1993.7.1) RNA helicase activity inferred from sequence or structural similarity (Dorn et al., 1993) inferred from sequence or structural similarity with Saccharomyces TIF2 (Lasko, 2000) single-stranded DNA-dependent ATP-dependent DNA helicase activity non-traceable author statement (Swiss-Prot Project Members, 1993.7.1) translation initiation factor activity inferred from sequence or structural similarity (Lasko, 2000) inferred from sequence or structural similarity with Saccharomyces TIF1 (FlyBase, 1992-) non-traceable author statement (Dorn, 1992.10.29, Swiss-Prot Project Members, 1993.7.1)
Biological Process
CV term Evidence References
DNA unwinding involved in replication non-traceable author statement (Swiss-Prot Project Members, 1993.7.1) imaginal disc growth traceable author statement (Weinkove and Leevers, 2000) instar larval development traceable author statement (Weinkove and Leevers, 2000) translational initiation inferred from sequence or structural similarity (Lasko, 2000) inferred from sequence or structural similarity with Saccharomyces TIF1 (FlyBase, 1992-) non-traceable author statement (Dorn, 1992.10.29, Swiss-Prot Project Members, 1993.7.1)
Cellular Component
CV term Evidence References
cytosol inferred from sequence or structural similarity (Lasko, 2000) non-traceable author statement (Dorn, 1992.10.29) eukaryotic translation initiation factor 4F complex inferred from sequence or structural similarity (Lasko, 2000) inferred from sequence or structural similarity with Saccharomyces TIF1 (FlyBase, 1992-) nucleus inferred by curator from GO:0000381 (Park et al., 2004)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions eIF-4a allele Gene References eIF-4a162-3 Dp (Galloni and Edgar, 1999) E2f (Galloni and Edgar, 1999) N (Rottgen et al., 1998) eIF-4a1006 Dp (Galloni and Edgar, 1999) E2f (Galloni and Edgar, 1999) Pten (Gao et al., 2000) eIF-4a1013 Dp (Galloni and Edgar, 1999) E2f (Galloni and Edgar, 1999) eIF-4a1069 Dp (Galloni and Edgar, 1999) E2f (Galloni and Edgar, 1999) Pten (Gao et al., 2000) eIF-4a02439 peb (Wilk et al., 2004) eIF-4ak14518 peb (Wilk et al., 2004) unspecified ct (Krupp et al., 2005) dpp (Li and Gelbart, 2002, Li et al., 2005) l(1)sc (Rottgen et al., 1998)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60000 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0001942 DroID - A comprehensive database of gene and protein interactions. • FBgn0001942 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33835
Orthologs
Genome-wide drosophilid orthologs	Dana\GF15595 Dere\GG25110 Dgri\GH11018 Dmoj\GI17537 Dper\GL19047 Dpse\GA21521 Dsec\GM18587 Dsim\GD23375 Dvir\GJ15436 Dwil\GK14711 Dyak\eIF-4a
Curated drosophilid orthologs	Dpse\GA21521   Dyak\eIF-4a
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL013359-PB Aedes aegypti (mosquito) AGAP009863-PA Anopheles gambiae (mosquito) XP_623285.1 Apis mellifera (honey bee) XP_001952053.1 Acyrthosiphon pisum (pea aphid) At3g13920.1 Arabidopsis thaliana (wall cress) 33571 Batrachochytrium dendrobatidis (chytrid fungus) 238703 Branchiostoma floridae (lancelet) 61658 Branchiostoma floridae (lancelet) XP_001894230.1 Brugia malayi (roundworm nematode) BGIBMGA003186-PA Bombyx mori (silk worm) ENSBTAP00000019596 Bos taurus (bovine) CAL0004095 Candida albicans (a form of yeast) CN30025 Caenorhabditis brenneri (small nematode) CBP03954 Caenorhabditis briggsae (nematode) CE01341 Caenorhabditis elegans (worm) ENSCAFP00000020138 Canis familiaris (dog) CAGL0I04356g Candida glabrata (haploid yeast) Chro.10108 Cryptosporidium hominis (obligate parasite) ENSCINP00000016021 Ciona intestinalis (sea squirt) JA15042 Caenorhabditis japonica (nematode) CMK028C Cyanidioschyzon merolae (red alga) cn01756 Cryptococcus neoformans (yeast-like fungus) cgd1_880 Cryptosporidium parvum (protozoan parasite) CPIJ001547 Culex pipens (mosquito) ENSCPOP00000010055 Cavia porcellus (guinea pig) 188942 Chlamidomonas reinhardtii (green alga) RP24902 Caenorhabditis remanei (nematode) ENSCSAVP00000001129 Ciona savignyi (sedentary tunicate) 202865 Capitella spl (polychaete worm) DEHA2D15048g Debaryomyces Hansenii (yeast) 230663 Daphnia pulex (daphnia) ENSDARP00000058912 Danio rerio (zebra fish) ENSECAP00000019166 Equus caballus (horse) ENSGACP00000026522 Gymnopilus aculeatus (mushroom) ENSGALP00000014119 Gallus gallus (chicken) GL50803_10255 Giardia lamblia (flagellated protozoan) 112831 Hypsipyla robusta (cedar shoot borer) ENSP00000326381 Homo sapiens (human) ISCW015864-PA Ixodes scapularis (deer tick) KLLA0A05731g Kluyveromyces lactis (yeast) 207101 Lottia gigantea (owl limpet) ENSMODP00000008799 Monodelphis domestica (gray opossum) ENSMMUP00000004942 Macaca mulatta (rhesus monkey) ENSMUSP00000110998 Mus musculus (house mouse) 236625 Nematostella vectensis (starlet anemone) XP_001599839.1 Nasonia vitripennis (wasp) ENSOANP00000006873 Ornithorynchus anatinus (platypus) ENSORLP00000011094 Oryzias latipes (japanese killifish) LOC_Os02g05330.1 Oryza sativa (asian rice) 28625 Ostreococcus tauri (green alga) PF14_0655 Plasmodium falciparum (protozoal parasite) PHUM001597-PA Pediculus humanus (human body louse) PP26933 Pristionchus pacificus (nematode) 107162 Physcomitrella patens (moss) 226898 Physcomitrella patens (moss) 233331 Physcomitrella patens (moss) ENSPPYP00000016089 Pongo pygmaeus (orangutan) 825619 Populus trichocarpa (black cottonwood) ENSPTRP00000027042 Pan troglodytes (chimpanzee) PVX_117030 Plasmodium vivax (protozoal parasite) ENSRNOP00000002484 Rattus norvegicus (norway rat) 150064 Sorghum bicolor (sorghum) YJL138C Saccharomyces cerevisiae (budding yeast) YKR059W Saccharomyces cerevisiae (budding yeast) SPAC1006.07 Schizosaccharomyces pombe (fission yeast) TA11470 Theileria annulata (apicomplexan parasite) TP02_0123 Theileria parva (parasitic protozoan) 9716 Thalassiosira pseudonana (marine diatom) ENSTRUP00000013706 Takifugu rubripes (pufferfish Takifugu) 97417.m00105 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000043428 Xenopus tropicalis (frog) YALI0B20922g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15901 NV17593 LH24849 ISCW015864 FBgn0067982 FBgn0216716 FBgn0202629 FBgn0194760 FBgn0173493 JGI_V11_230663 FBgn0081507 FBgn0156647 FBgn0140281 FBgn0118499 FBgn0117238 FBgn0092619 CPIJ001547 BGIBMGA003186 ACYPI002483 GB19724 AGAP009863 AAEL013359 PHUM148640 GLEAN_14113
Stocks & Reagents
Stocks Listed in FlyBase ( 19 )
Bloomington	8647 w*; P{lacW}eIF-4a1013/CyO 11190 P{PZ}eIF-4a02439 cn1/CyO; ry506 33970 y1 sc* v1; P{TRiP.HMS00927}attP2 10506 y1 w67c23; P{lacW}eIF-4ak01501/CyO
Harvard	- P{XP}eIF-4ad06487
Kyoto	123245 w1118; P{RS3}eIF-4aCB-0582-3 123292 w1118; P{RS3}eIF-4aCB-0707-3 124307 w1118; P{RS3}eIF-4aUM-8048-3 125515 w1118; P{RS5}eIF-4a5-HA-1998
VDRC	v100310 P{KK107917}VIE-260B v42202 w1118; P{GD14111}v42202 v42201 w1118; P{GD14111}v42201/CyO
	More stocks available...
Genomic Clones ( 2 )
	BACR10M11 BACR48E14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 910 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT04852 GH03937 GH17619 GM14109 RE22480
Other clones	LD22268 yak-em_eIF
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT02170 AT03112 AT04436 AT08483 AT09694 AT13057 AT13234 AT14958 AT23385 AT28812 AT29165 GH03487 GH03971 GH04406 GH10237 GH12628 GH13143 GH17568 GH17902 GH17993 GH19458 GH20855 GH22211 GH23403 GH25019 GH28093 GM02255 GM02949 GM03589 GM04868 GM05852 GM06410 GM07523 GM07620 GM09465 GM09633 GM10135 GM10276 GM12817 GM13046 GM13668 GM14727 GM15538 GM15563 GM17171 GM23357 GM24441 GM25511 GM30446 HL01093 LD03032 LD03986 LD05294 LD06175 LD06879 LD07504 LD09168 LD09670 LD10089 LD10520 LD11417 LD12205 LD12478 LD14489 LD14793 LD18790 LD23136 LD23242 LD25394 LD25720 LD25905 LD26166 LD26628 LD26891 LD28016 LD28387 LD29095 LD30890 LD30912 LD35575 LD35634 LD35684 LD37188 LD37340 LD37576 LD37586 LD38110 LD38361 LD39274 LD39682 LD39824 LD40270 LD40743 LD40813 LD41145 LD41960 LD42775 LD43215 LD43385 LD43393 LD43453 LD43487 LD45372 LD45777 LD46296 LD46374 LD46549 LD46672 LP01922 LP02971 LP03323 LP04994 LP07996 LP08062 LP08516 LP08927 LP09159 LP09453 LP10454 LP10466 LP13302 LP14610 LP14775 LP17260 LP19180 LP20469 RE33667 RE72606 RH13985 RH15860 RH28612 RH48244 RH61195 RH64119 RH71787 SD01050 SD01324 SD02408 SD03701 SD06978 SD07602 SD07627 SD08035 SD08123 SD10363 SD10971 SD11872 SD12088 SD12273 SD12396 SD12655 SD12781 SD13028 SD13676 SD14122 SD14636 SD14908 SD16032 SD17637 SD17834 SD18187 SD18636 SD19033 SD19046 SD19231 SD19260 SD19869 SD20034 SD20504 SD20615 SD21790 SD21991 SD22282 SD23011 SD23347 SD23491 SD24302 SD24372 SD26131 SD26286 SD26407 SD26774 SD27010 SD27187 SD27237 SD28279
Other clones	14748 521770 522186 524773 525476 527094 542778 556916 557873 568931 571190 AT01838 AT05848 AT06172 AT09680 AT18822 AT20608 AT27636 bs22d04 CK01.71A.C3 Dmel_dig_013231_0666_1757 Dmel_dig_013487_0595_3704 Dmel_dig_019064_0631_2094 Dmel_dig_020281_0666_2543 Dmel_neb_000289_0157_0336 Dmel_neb_005129_0343_0322 Dmel_neb_005746_0611_3622 Dmel_neb_008478_0190_1288 Dmel_neb_008593_0829_2942 Dmel_neb_010733_0879_1851 Dmel_neb_011850_0690_3461 Dmel_neb_012949_0585_3147 Dmel_neb_013357_0845_1943 Dmel_neb_013742_0420_3126 Dmel_neb_014523_0580_0561 Dmel_neb_014549_0124_1710 Dmel_neb_014790_0859_1752 EC14594 EC22941 EC25004 EC36618 EC055061 EC055108 EC055548 EC055963 EK050021 EK056410 EK119531 EK138206 EK156940 EK166542 EK169018 EK197453 EK198541 EK217447 EK230441 EK242659 EK265601 EK269950 EK270328 EK296121 EK303445 EN01527 EN02363 EN03603 EN04205 EN05912 EN06562 EN06920 EN07249 EN09403 EN11036 EN11318 EN11660 EN12551 EN13863 EN14009 EN14216 EN16314 EN17663 EP03506 EP08512 EP08922 EP09461 ESG015d.B21_D09 ESG019c.E21_A05 ESG019d.E21_H11 ESG0110a.E21_B09 ESG0110a.E21_H06 ESG0112b.B21_E08 ESG0114c.B21_H12 ESG0115a.B21_G10 ESG0119d.B21_G05 FGA005E07 FGC006A12 FGC010D08 FGC011B01 FGC019A12 FGC021C11 FGC031E08 FGH117C04 FGH121B04 FGH121E03 FGH123D04 FGH128D07 FGM105G05 FGM206A02 FGM215F03 FGM220E10 FGM230C10 FGM231G01 FGM237B09 FGM310C11 FGM314B02 FGM316C01 GH01280 GH01548 GH02849 GH04276 GH04694 GH04730 GH05176 GH05662 GH05838 GH05844 GH07326 GH07470 GH08232 GH08496 GH09245 GH09290 GH09424 GH09441 GH09562 GH11636 GH12650 GH12651 GH12736 GH12878 GH12956 GH13294 GH13763 GH13886 GH13976 GH14039 GH14843 GH15612 GH15928 GH16539 GH16553 GH16744 GH16957 GH17035 GH17735 GH18093 GH18604 GH18867 GH19160 GH19518 GH20174 GH20261 GH20290 GH21026 GH21454 GH21827 GH21907 GH21965 GH22079 GH22202 GH22419 GH23089 GH23269 GH23273 GH23488 GH23619 GH23812 GH23946 GH24417 GH24663 GH25006 GH25040 GH25936 GH26156 GH26930 GH28548 GH28637 GH28703 GH28841 GM01545 GM01624 GM03424 GM03475 GM03637 GM03780 GM06133 GM06320 GM06888 GM07826 GM09065 GM09944 GM10764 GM12317 GM13521 GM13672 GM20661 GM23273 GM23731 GM24301 GM25419 GM27260 GM27578 GM30369 GM31425 GM31671 GM31813 GM32189 HL01442 HL02249 HL02453 HL03155 HL03181 HL03183 HL03234 HL05560 HL06574 HL06612 IP02171 IP03502 IP06007 IP06494 IP06694 IP06966 IP08851 IP08951 IP09012 IP09051 IP09151 IP09620 IP09720 IP09820 IP09920 IP11917 IP12276 IP13689 IP13789 IP13889 IP13989 LD01034 LD01849 LD02494 LD02764 LD02915 LD02928 LD03237 LD03272 LD03327 LD03649 LD03665 LD03766 LD05432 LD06015 LD06856 LD06869 LD07626 LD07706 LD08044 LD10369 LD11241 LD11735 LD12744 LD13402 LD14401 LD16184 LD17539 LD18238 LD19026 LD19387 LD20491 LD20654 LD21153 LD21343 LD22226 LD23180 LD23235 LD23347 LD23585 LD23960 LD24289 LD24379 LD24605 LD24745 LD24956 LD25313 LD25710 LD25868 LD26008 LD26244 LD26464 LD27157 LD27423 LD27603 LD27662 LD28185 LD28229 LD28624 LD28631 LD28738 LD28846 LD29088 LD29118 LD29265 LD29314 LD30078 LD30273 LD30695 LD30802 LD30952 LD31171 LD31407 LD31722 LD31873 LD32182 LD32305 LD33340 LD33673 LD33784 LD33792 LD33978 LD34046 LD34204 LD34466 LD34506 LD34561 LD34982 LD35335 LD35630 LD35710 LD35877 LD35971 LD36033 LD36145 LD36457 LD36593 LD37020 LD37751 LD38838 LD38840 LD38879 LD39248 LD39325 LD39542 LD40018 LD40172 LD40550 LD41236 LD41354 LD41844 LD42003 LD42305 LD42492 LD43163 LD43258 LD43533 LD43642 LD44174 LD45255 LD45530 LD45940 LD46075 LD46179 LD46405 LD47125 LD47275 LD47756 LP02205 LP02319 LP02534 LP02949 LP03085 LP03153 LP03626 LP04027 LP04029 LP06271 LP06353 LP07322 LP08747 LP11121 LP11946 LP12124 LP12130 LP12365 LP12510 LP12842 LP12853 LP13058 LP13395 LP13426 LP13607 LP13894 LP15592 LP15837 LP16951 LP17206 LP17210 LP17550 LP17825 LP19367 LP19772 LP20349 LP20760 LP22101 LP22877 LP23148 LP23866 LP24268 RE01894 RE03387 RE04311 RE04691 RE06572 RE06762 RE07782 RE07852 RE09811 RE13858 RE15110 RE15765 RE16207 RE16662 RE16746 RE18846 RE21656 RE22870 RE23181 RE25204 RE25365 RE26032 RE26494 RE27780 RE27825 RE28070 RE30505 RE31161 RE31417 RE31653 RE33295 RE34035 RE34721 RE37176 RE38290 RE38295 RE38916 RE41370 RE43584 RE43749 RE44731 RE44812 RE46261 RE46751 RE46820 RE47710 RE49185 RE49303 RE51203 RE52636 RE53236 RE55395 RE59366 RE60208 RE60852 RE61176 RE62180 RE62384 RE62949 RE62984 RE63190 RE66746 RE66768 RE69227 RH04865 RH05278 RH06574 RH07557 RH07559 RH09971 RH09995 RH10406 RH11221 RH12112 RH12485 RH13510 RH15925 RH16168 RH16207 RH16259 RH17266 RH17364 RH17865 RH18180 RH20162 RH20165 RH20316 RH20427 RH20902 RH21475 RH21772 RH22704 RH22881 RH23091 RH23221 RH23489 RH23804 RH23896 RH24015 RH25592 RH25850 RH26027 RH26581 RH26814 RH26942 RH27029 RH27361 RH27472 RH27488 RH27525 RH27556 RH28560 RH28789 RH28831 RH28857 RH29950 RH30624 RH30757 RH31542 RH31585 RH32193 RH32680 RH32911 RH33721 RH34189 RH35280 RH35295 RH35435 RH36153 RH36207 RH36367 RH36635 RH37216 RH37291 RH37307 RH37837 RH37913 RH38247 RH38415 RH38595 RH38752 RH38895 RH38909 RH38947 RH38994 RH39071 RH39216 RH39238 RH39522 RH39741 RH39759 RH39955 RH40081 RH40207 RH40356 RH40363 RH42161 RH42692 RH43088 RH43150 RH43180 RH43394 RH43553 RH43570 RH43636 RH43725 RH43743 RH44964 RH45439 RH45520 RH45749 RH45939 RH46728 RH47492 RH49384 RH49536 RH50004 RH50094 RH50223 RH50607 RH50656 RH50993 RH51176 RH51370 RH52201 RH52468 RH52545 RH53112 RH53212 RH56524 RH56666 RH56687 RH57744 RH58503 RH58589 RH58775 RH58849 RH59143 RH60838 RH61215 RH61425 RH61435 RH61765 RH61860 RH61864 RH62238 RH63371 RH63743 RH64050 RH64159 RH64166 RH64167 RH65563 RH65993 RH66157 RH66280 RH66293 RH66321 RH66659 RH66881 RH67813 RH69170 RH69508 RH70324 RH70677 RH70746 RH70755 RH70949 RH71146 RH71888 RH72977 RH73501 RH74144 RH74256 RH74426 RH74651 RP004031146 RP004032786 RP004076171 RP004091908 RP004102521 RP004119853 RP004135380 RP004152082 RP004171531 RP004184085 RP004186084 RP004209153 RP004211000 RP004217691 RP004218216 RP004224528 RP004225285 RP004226549 RP004235742 RP004245578 RP004255883 RP004259464 RP004342008 RP004344296 RP004367799 RP004385457 RP004452093 RP004458865 RP004459431 RP004479482 RP004481278 RP004484174 RP004509618 RP004534614 RP004537738 RP004544633 RP004560005 SD03839 SD04721 SD04778 SD05011 SD05312 SD05557 SD05958 SD06717 SD10376 SD10532 SD10741 SD11784 SD11902 SD12547 SD13048 SD14246 SD14869 SD15003 SD15187 SD16453 SD22417 SD23381 SD23443 SD24453 SD26424 SD27030 SD27516 SD27757
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0001942 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33835
Antibody Information
	polyclonal (Hernandez et al., 2004)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: eIF-4a l(2)k01501 (Spradling et al., 1999) Source for merge of: eIF-4a Su(dpp)YE9 (Li et al., 2005)
Additional comments
Other Comments
	RNAi screen using dsRNA made from templates generated with primers directed against this gene results in aberrantly short, monopolar spindles when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA. (Goshima et al., 2007) S2 cells transfected with dsRNA made from templates generated with primers directed against this gene show significantly lower levels of global translation within 2 days. (Coelho et al., 2005) RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) Identification: identified in a genetic screen for suppressors of the dppH46 phenotype. (Li and Gelbart, 2002) Maternal and zygotic suppressor of dppH46. Homozygous embryonic lethal. Cuticle phenotypes of homozygous mutant embryos show dorsal-ventral patterning defects. eIF-4a can completely rescue the maternal-effect lethality caused by Mad, sax double mutants. (Li and Gelbart, 2002) Identification: One of a collection of genes identified with defective larval growth that extend larval life. (Galloni and Edgar, 1999) Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland. (Harvie et al., 1998) Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology. (Roch et al., 1998) A single copy gene. (Dorn et al., 1993) 1.6kb non-sex-specific transcript located close to Acp26Aa in the 26A region. (Monsma and Wolfner, 1988)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057247 NM_164668 NM_164669 NM_164670 RefSeq (Proteins) • NP_476595 NP_723137 NP_723138 NP_723139 DDBJ / EMBL / GenBank • AA697086 AA803725 AAD38596 AAF52317 AAL39428 AAM51950 AAN10566 AAN10567 AAN10568 AC004268 AC004758 AC092216 AF145621 AI063841 AI401935 AI946230 AQ034134 AQ072952 AQ254819 AW940665 AW941379 AY069283 AY121623 AZ300927 CAA48790 CZ475160 G01428 X69045 Entrez Gene - A searchable database of RefSeq genes. • 33835 UniProtKB/Swiss-Prot • Q02748
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • RNA helicase, ATP-dependent, DEAD-box, conserved site (IPR000629) Helicase, C-terminal (IPR001650) DNA/RNA helicase, DEAD/DEAH box type, N-terminal (IPR011545) DEAD-like helicase (IPR014001) RNA helicase, DEAD-box type, Q motif (IPR014014)
Linkouts
	BioGRID - A database of protein and genetic interactions • 60000 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0001942 DroID - A comprehensive database of gene and protein interactions. • FBgn0001942 DRSC - Results from RNAi screens. • FBgn0001942 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001942 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9075-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0001942 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 33835 InParanoid A subset of ortholog calls from InParanoid. • AAEL013359-PB Aedes aegypti (mosquito) AGAP009863-PA Anopheles gambiae (mosquito) XP_623285.1 Apis mellifera (honey bee) XP_001952053.1 Acyrthosiphon pisum (pea aphid) At3g13920.1 Arabidopsis thaliana (wall cress) 33571 Batrachochytrium dendrobatidis (chytrid fungus) 238703 Branchiostoma floridae (lancelet) 61658 Branchiostoma floridae (lancelet) XP_001894230.1 Brugia malayi (roundworm nematode) BGIBMGA003186-PA Bombyx mori (silk worm) ENSBTAP00000019596 Bos taurus (bovine) CAL0004095 Candida albicans (a form of yeast) CN30025 Caenorhabditis brenneri (small nematode) CBP03954 Caenorhabditis briggsae (nematode) CE01341 Caenorhabditis elegans (worm) ENSCAFP00000020138 Canis familiaris (dog) CAGL0I04356g Candida glabrata (haploid yeast) Chro.10108 Cryptosporidium hominis (obligate parasite) ENSCINP00000016021 Ciona intestinalis (sea squirt) JA15042 Caenorhabditis japonica (nematode) CMK028C Cyanidioschyzon merolae (red alga) cn01756 Cryptococcus neoformans (yeast-like fungus) cgd1_880 Cryptosporidium parvum (protozoan parasite) CPIJ001547 Culex pipens (mosquito) ENSCPOP00000010055 Cavia porcellus (guinea pig) 188942 Chlamidomonas reinhardtii (green alga) RP24902 Caenorhabditis remanei (nematode) ENSCSAVP00000001129 Ciona savignyi (sedentary tunicate) 202865 Capitella spl (polychaete worm) DEHA2D15048g Debaryomyces Hansenii (yeast) 230663 Daphnia pulex (daphnia) ENSDARP00000058912 Danio rerio (zebra fish) ENSECAP00000019166 Equus caballus (horse) ENSGACP00000026522 Gymnopilus aculeatus (mushroom) ENSGALP00000014119 Gallus gallus (chicken) GL50803_10255 Giardia lamblia (flagellated protozoan) 112831 Hypsipyla robusta (cedar shoot borer) ENSP00000326381 Homo sapiens (human) ISCW015864-PA Ixodes scapularis (deer tick) KLLA0A05731g Kluyveromyces lactis (yeast) 207101 Lottia gigantea (owl limpet) ENSMODP00000008799 Monodelphis domestica (gray opossum) ENSMMUP00000004942 Macaca mulatta (rhesus monkey) ENSMUSP00000110998 Mus musculus (house mouse) 236625 Nematostella vectensis (starlet anemone) XP_001599839.1 Nasonia vitripennis (wasp) ENSOANP00000006873 Ornithorynchus anatinus (platypus) ENSORLP00000011094 Oryzias latipes (japanese killifish) LOC_Os02g05330.1 Oryza sativa (asian rice) 28625 Ostreococcus tauri (green alga) PF14_0655 Plasmodium falciparum (protozoal parasite) PHUM001597-PA Pediculus humanus (human body louse) PP26933 Pristionchus pacificus (nematode) 107162 Physcomitrella patens (moss) 226898 Physcomitrella patens (moss) 233331 Physcomitrella patens (moss) ENSPPYP00000016089 Pongo pygmaeus (orangutan) 825619 Populus trichocarpa (black cottonwood) ENSPTRP00000027042 Pan troglodytes (chimpanzee) PVX_117030 Plasmodium vivax (protozoal parasite) ENSRNOP00000002484 Rattus norvegicus (norway rat) 150064 Sorghum bicolor (sorghum) YJL138C Saccharomyces cerevisiae (budding yeast) YKR059W Saccharomyces cerevisiae (budding yeast) SPAC1006.07 Schizosaccharomyces pombe (fission yeast) TA11470 Theileria annulata (apicomplexan parasite) TP02_0123 Theileria parva (parasitic protozoan) 9716 Thalassiosira pseudonana (marine diatom) ENSTRUP00000013706 Takifugu rubripes (pufferfish Takifugu) 97417.m00105 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000043428 Xenopus tropicalis (frog) YALI0B20922g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33835 modMine - Data generated by the modENCODE project. • FBgn0001942 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15901 NV17593 LH24849 ISCW015864 FBgn0067982 FBgn0216716 FBgn0202629 FBgn0194760 FBgn0173493 JGI_V11_230663 FBgn0081507 FBgn0156647 FBgn0140281 FBgn0118499 FBgn0117238 FBgn0092619 CPIJ001547 BGIBMGA003186 ACYPI002483 GB19724 AGAP009863 AAEL013359 PHUM148640 GLEAN_14113
Synonyms & Secondary IDs ( 35 )
Reported As
Symbol Synonym	2439 (Harvie et al., 1998) 9075 (Ravi et al., 2009) anon26A   anon-26Aa   CG9075 (Kraut et al., 2001, Kraut et al., 2001, Lasko, 2000, Whitfield, 2000.5.17, Quinones-Coello, 2007, Goshima et al., 2007, Molnar et al., 2006, Ducat et al., 2008, Ida et al., 2009, Keleman et al., 2009.8.5, Hughes et al., 2008, McIntyre et al., 2006, Ni et al., 2010.12.1, Hernandez et al., 2004, Cammarato et al., 2011) deIF4A (Garrey et al., ) Dm-eIF4A (Hernandez et al., 2004) DmRH2 (Boudet et al., 2001) eIF4A (Coelho et al., 2005, Li et al., 2005, Bjorklund et al., 2006, Lasko, 2000, Carrera et al., 2000, Lehner, 1999, Verheyen and Cooley, 1994, Andersen and Leevers, 2007, Franklin-Dumont et al., 2007, Li and Li, 2006, Shen et al., 2009, Thomson et al., 2008, Park et al., 2010, Hernandez et al., 2004, Singh et al., 2011) eif4A (Orian et al., 2003, Gao et al., 2000, Galloni and Edgar, 1999, Galloni and Edgar, 1999) Eif-4a (Morin et al., 2001) EIF-4A (Boudet et al., 2001, Hernandez et al., 2004) eIF-4A (van Steensel et al., 2001, Beller et al., 2006, Takahashi et al., 2005, Fuller and Baker, 2007.6.28, Kent et al., 2009) EiF4A (Weinkove and Leevers, 2000) eif-4a (Basu and Li, 1998) Eif4a   eIF-4a (Christensen and Cook, 2006.8.29, Wang et al., 2004, Stuart et al., 2007, Buszczak et al., 2007, Quinones-Coello, 2007, Goshima et al., 2007, Molnar et al., 2006, Lipatov et al., 2005, Ida et al., 2009, Katzenberger et al., 2009, McIntyre et al., 2006, Zhou et al., 2008, Franco et al., 2011, Müller et al., 2010) eIF4a (Blanco et al., 2010, Abel et al., 2009, Insco et al., 2009) eIF 4A (Ducat et al., 2008) eIF-4a-I (Hernandez and Vazquez-Pianzola, 2005) eIF4A-I (Hernandez and Vazquez-Pianzola, 2005) eIF4AI (Palacios et al., 2004) l(2)26Ac   l(2)162   l(2)02439   l(2)gdh-4 (Knipple and MacIntyre, 1984, Kotarski et al., 1983, ) l(2)k01501 (BDGP Project Members, 1994-1999, ) l(2L)162 (Dorn, 1992.10.29, Dorn et al., 1993, ) L(2L)162 (Hernandez et al., 2004) Su(dpp)YE9 (Li and Gelbart, 2002, ) unnamed (Monsma and Wolfner, 1988)
Name Synonym	Eukaryotic initiation factor 4a (Cammarato et al., 2011) Eukaryotic initiation factor 4A (Costello et al., 2009) eukaryotic translation initiation factor 4A (Li and Li, 2006, Kent et al., 2009) translation initiation factor 4A (Hernandez et al., 2004)
Secondary FlyBase IDs
	FBgn0013406 FBgn0013523 FBgn0015864 FBgn0022247 FBgn0024969 FBgn0062252
References ( 110 )
Generate a list of	All references relating to this gene ( 110 )
List References by type	Research paper  ( 64 ) Supplementary material  ( 11 ) Review  ( 4 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 5 ) FlyBase analysis  ( 3 ) Letter  ( 1 ) DNA/RNA sequence record  ( 2 ) Computer file  ( 4 ) Protein sequence record  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 ) Book  ( 1 )
Recent research papers ( 5 )
	Franco et al., 2011, Mol. Cell. Proteomics 10(5): M110.002188 A Novel Strategy to Isolate Ubiquitin Conjugates Reveals Wide Role for Ubiquitination during Neural Development. [FBrf0213919] Singh et al., 2011, Dev. Biol. 352(1): 104--115 The Bin3 RNA methyltransferase is required for repression of caudal translation in the Drosophila embryo. [FBrf0213172] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Müller et al., 2010, EMBO J. 29(19): 3344--3357 Proteomic and functional analysis of the mitotic Drosophila centrosome. [FBrf0212030] Park et al., 2010, Biochim. biophys. Acta 1799(7): 510--519 Regulation of the Drosophila p38b gene by transcription factor DREF in the adult midgut. [FBrf0211129] Show all research papers ...
Recent reviews ( 1 )
	Arkov and Ramos, 2010, Trends Cell Biol. 20(8): 482--490 Building RNA-protein granules: insight from the germline. [FBrf0212430] Show all reviews ...