FB2021_05, released October 15, 2021

Gene: Dmel\eIF4A

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General Information
Symbol
Dmel\eIF4A
Species
D. melanogaster
Name
eukaryotic translation initiation factor 4A
Annotation Symbol
CG9075
Feature Type
protein_coding_gene
FlyBase ID
FBgn0001942
Gene Model Status
Current
Stock Availability
22 publicly available
Enzyme Name (EC)
RNA helicase (3.6.4.13)
Gene Summary
eukaryotic translation initiation factor 4A (eIF4A) encodes an essential DEAD-box RNA helicase protein and a canonical translation initiation factor. It is a component of the eIF4F cap-binding complex that is essential for cap-dependent translation of mRNA. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

eIF-4a, l(2)gdh-4, l(2L)162, Su(dpp)YE9, eukaryotic initiation factor 4A

Key Links
Genomic Location
Cytogenetic map
26B2-26B2
Sequence location
Recombination map
2-18
RefSeq locus
NT_033779 REGION:5981764..5985909
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (18 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables SMAD binding
inferred from physical interaction with FLYBASE:Mad; FB:FBgn0011648
(Li and Li, 2006)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR011545
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables RNA helicase activity
inferred from sequence or structural similarity with SGD:S000003674
(Lasko, 2000)
enables translation initiation factor activity
inferred from biological aspect of ancestor with PANTHER:PTN002777147
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred from sequence or structural similarity
(Lasko, 2000)
Biological Process (10 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
involved_in female germ-line stem cell asymmetric division
inferred from mutant phenotype
(Shen et al., 2009)
inferred from genetic interaction with FLYBASE:bam; FB:FBgn0000158
(Shen et al., 2009)
involved_in germ-line stem cell population maintenance
inferred from mutant phenotype
(Shen et al., 2009)
involved_in mitotic cell cycle
inferred from high throughput mutant phenotype
(Ducat et al., 2008)
involved_in negative regulation of BMP signaling pathway
inferred from direct assay
(Li and Li, 2006)
inferred from mutant phenotype
(Li and Li, 2006)
involved_in oogenesis
inferred from genetic interaction with FLYBASE:bam; FB:FBgn0000158
(Shen et al., 2009)
inferred from mutant phenotype
(Jagut et al., 2013)
involved_in pole cell formation
inferred from genetic interaction with FLYBASE:tud; FB:FBgn0003891
(Thomson et al., 2008)
inferred from genetic interaction with FLYBASE:vas; FB:FBgn0283442
(Thomson et al., 2008)
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process
inferred from direct assay
(Li and Li, 2006)
involved_in regulation of alternative mRNA splicing, via spliceosome
inferred from high throughput mutant phenotype
(Park et al., 2004)
inferred from mutant phenotype
(Katzenberger et al., 2009)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in cytoplasmic translational initiation
inferred from biological aspect of ancestor with PANTHER:PTN002777147
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in translational initiation
inferred from sequence or structural similarity
(Lasko, 2000)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in cytosol
inferred from direct assay
(Li and Li, 2006)
located_in nucleus
inferred from high throughput direct assay
(Lee et al., 2014)
located_in P granule
inferred from direct assay
(Thomson et al., 2008)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
located_in cytosol
inferred from sequence or structural similarity
(Lasko, 2000)
part_of eukaryotic translation initiation factor 4F complex
inferred from sequence or structural similarity
(Lasko, 2000)
located_in nucleus
inferred by curator from GO:0000381
(Park et al., 2004)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the DEAD box helicase family. eIF4A subfamily. (Q02748)
Protein Signatures (InterPro)
Catalytic Activity (EC)
Experimental Evidence
-
Predictions / Assertions
ATP + H(2)O = ADP + phosphate (3.6.4.13)
Summaries
Gene Snapshot
eukaryotic translation initiation factor 4A (eIF4A) encodes an essential DEAD-box RNA helicase protein and a canonical translation initiation factor. It is a component of the eIF4F cap-binding complex that is essential for cap-dependent translation of mRNA. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
CYTOPLASMIC TRANSLATION INITIATION FACTORS -
Cytoplasmic (or eukaryotic) translation initiation factors function in the initiation stage of ribosome-mediated translation in the cytoplasm. (Adapted from FBrf0233552 and PMID:20094052).
DEAD-BOX RNA HELICASES -
DEAD-box RNA helicases belong to helicase superfamily 2 (SF2). They are characterized by the presence of nine conserved helicase motifs, including the DEAD sequence in motif II. (Adapted from PMID:21509200.)
Pathway (FlyBase)
Negative Regulators of BMP Signaling Pathway -
Negative regulators of Bone Morphogenetic Protein (BMP) signaling down-regulate the pathway, ultimately resulting in the decreased nuclear activity of the Mad/Med transcription factor complex.
Protein Function (UniProtKB)
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. Involved in germ cell formation.
(UniProt, Q02748)
Gene Model and Products
Number of Transcripts
6
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\eIF4A for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.55

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.44

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
eIF4A-RA
FBtr0079175
NM_164668
1691
403
eIF4A-RB
FBtr0079177
NM_164669
1847
403
eIF4A-RC
FBtr0079176
NM_057247
1553
403
eIF4A-RD
FBtr0079178
NM_164670
1960
403
eIF4A-RE
FBtr0307068
NM_001258978
2021
403
eIF4A-RF
FBtr0331201
NM_001273188
1939
403
Additional Transcript Data and Comments
Reported size (kB)

1.9, 1.75 (northern blot)

(Dorn et al., 1993)

2.2, 2.0 (northern blot)

(Cooley et al., 1992)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
eIF4A-PA
FBpp0078806
45.9
403
5.34
NP_723137
AAF52317
eIF4A-PB
FBpp0078808
45.9
403
5.34
NP_723138
AAN10567
eIF4A-PC
FBpp0078807
45.9
403
5.34
NP_476595
AAN10566
eIF4A-PD
FBpp0078809
45.9
403
5.34
NP_723139
AAN10568
eIF4A-PE
FBpp0297911
45.9
403
5.34
NP_001245907
AFH03581
eIF4A-PF
FBpp0303628
45.9
403
5.34
NP_001260117
AGB92653
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

403 aa isoforms: eIF4A-PA, eIF4A-PB, eIF4A-PC, eIF4A-PD, eIF4A-PE, eIF4A-PF
Additional Polypeptide Data and Comments
Reported size (kDa)

402 (aa)

(Dorn et al., 1993)
Comments
External Data
Subunit Structure (UniProtKB)

eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E1 and eIF4G1. Interacts with tud and vas.

(UniProt, Q02748)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\eIF4A using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism | ubiquitous | uniform
(Hernandez et al., 2004)
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | ubiquitous
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism | ubiquitous
(Dorn et al., 1993)
embryonic stage -- adult stage
(Dorn et al., 1993)
organism
(Hernandez et al., 2004)
Additional Descriptive Data

eIF-4a transcripts are detected at all developmental stages. In embryos, they are already present in large amounts in fertilized eggs and are abundant in all tissues at later stages of development.

(Dorn et al., 1993)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism | ubiquitous | uniform
(Hernandez et al., 2004)
embryonic stage 5
organism
(Hernandez et al., 2004)
third instar larval stage
wing disc | ubiquitous | uniform
(Hernandez et al., 2004)
haltere disc | ubiquitous | uniform
(Hernandez et al., 2004)
ventral thoracic disc | ubiquitous | uniform
(Hernandez et al., 2004)
eye-antennal disc | ubiquitous | uniform
(Hernandez et al., 2004)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data

eIF-4a protein is ubiquitously distributed at all embryonic stages. In cellular blastoderms, protein is significantly accumulated in the apical cortex of blastoderm cells. eIF-4a protein is evenly distributed in wing, haltere, leg, and eye-antennal discs.

(Hernandez et al., 2004)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytosol
inferred from direct assay
(Li and Li, 2006)
located_in nucleus
inferred from high throughput direct assay
(Lee et al., 2014)
located_in P granule
inferred from direct assay
(Thomson et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\eIF4A in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 63 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of eIF4A
Transgenic constructs containing regulatory region of eIF4A
Aberrations (Deficiencies and Duplications) ( 27 )
Inferred from experimentation ( 27 )
Gene disrupted in
Df(2L)BSC184
(Christensen and Cook, 2006.8.29)
Df(2L)chic-106
(Verheyen and Cooley, 1994)
Df(2L)chic-112
(Verheyen and Cooley, 1994)
Df(2L)chic-129
(Verheyen and Cooley, 1994)
Df(2L)chic38
(Verheyen and Cooley, 1994)
Df(2L)chic103
(Verheyen and Cooley, 1994)
Df(2L)chic139
(Verheyen and Cooley, 1994)
Df(2L)cl-h3
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
Df(2L)E110
(Li et al., 2005, Spradling et al., 1999, BDGP Project Members, 1994-1999)
Df(2L)ED299
(Marygold et al., 2007)
Df(2L)ED354
(Marygold et al., 2007)
Df(2L)ED385
(Marygold et al., 2007)
Df(2L)Exel8017
(Ryder, 2004.4.26)
Df(2L)Gpdh1-A
(Li et al., 2005, Spradling et al., 1999, Beaton, 1997.3.4, BDGP Project Members, 1994-1999, Dorn et al., 1993, Kotarski et al., 1983)
Ts(YLt;2Lt)H69+Ts(YLt;2Rt)D211
(Kotarski et al., 1983)
Gene not disrupted in
Df(2L)2802
(Kotarski et al., 1983)
Df(2L)ade2-3
(BDGP Project Members, 1994-1999)
Df(2L)cl1
(Kotarski et al., 1983)
Df(2L)cl2
(Kotarski et al., 1983)
Df(2L)cl7
(Dorn et al., 1993, Kotarski et al., 1983)
Df(2L)Gpdh1-75
(Kotarski et al., 1983)
Df(2L)Gpdh1-78
(Kotarski et al., 1983)
Df(2L)TW161
(BDGP Project Members, 1994-1999)
Df(2R)M60E
(BDGP Project Members, 1994-1999)
Df(2R)Np3
(BDGP Project Members, 1994-1999)
Df(2R)Np5
(BDGP Project Members, 1994-1999)
Df(2R)Pu-D17
(BDGP Project Members, 1994-1999)
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4nub-AC-62
lethal, with Scer\GAL4pnr-MD237
lethal (with Df(2L)Gpdh1-A)
lethal | embryonic stage (with Df(2L)E110)
lethal | female limited, with Scer\GAL4dome-PG14
lethal | first instar larval stage (with Df(2L)E110)
lethal | first instar larval stage (with eIF4A02439)
lethal | first instar larval stage (with eIF4AYE9)
lethal | pupal stage, with Scer\GAL4pnr-MD237
lethal | recessive
lethal | second instar larval stage (with Df(2L)E110)
lethal | second instar larval stage (with eIF4A02439)
lethal | second instar larval stage (with eIF4AYE9)
lethal | third instar larval stage (with Df(2L)E110)
lethal - all die before end of larval stage, with Scer\GAL4en-e16E
lethal - all die before end of larval stage | recessive
lethal - all die during embryonic stage | recessive
lethal - all die during larval stage, with Scer\GAL4Mef2.PR
partially lethal, with Scer\GAL4tin.CΔ4
partially lethal - majority die | recessive
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
Other Phenotypes
Allele
abnormal developmental rate | dominant | larval stage
abnormal mitotic cell cycle | recessive
abnormal neuroanatomy, with Scer\GAL4elav-C155
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4repo
decreased cell number | cell autonomous | larval stage | somatic clone
decreased cell number | germline clone
decreased cell number | third instar larval stage, with Scer\GAL4repo
decreased occurrence of cell division | larval stage
some die during embryonic stage | recessive
some die during larval stage, with Scer\GAL4tin.CΔ4
some die during larval stage | recessive
Phenotype manifest in
Allele
amnioserosa
amnioserosa (with Df(2L)Gpdh1-A)
anterior fascicle & synapse, with Scer\GAL4elav-C155
centrosome | germline clone
cephalopharyngeal skeleton
cuticle
egg chamber | germline clone
embryonic/first instar larval cuticle
embryonic/larval optic stalk | third instar larval stage, with Scer\GAL4repo
embryonic/larval salivary gland, with Scer\GAL4fkh.PH
eye
eye disc | third instar larval stage, with Scer\GAL4repo
female germline stem cell | germline clone
glial cell | third instar larval stage, with Scer\GAL4repo
head
larval intersegmental nerve, with Scer\GAL4elav-C155
oocyte | germline clone
parasegment 1
parasegment 2
parasegment 3
parasegment 4
parasegment 5
parasegment 6
parasegment 7
parasegment 8
parasegment 9
parasegment 10
parasegment 11
parasegment 12
parasegment 13
parasegment 14
parasegment 15
wing disc
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\EIF4A1
12 of 15
Yes
Yes
Hsap\EIF4A2
12 of 15
Yes
Yes
Hsap\EIF4A3
2 of 15
No
No
Hsap\CDK2
1 of 15
No
No
1  
Hsap\MIR1248
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (4)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Eif4a1
12 of 15
Yes
Yes
Mmus\Eif4a2
12 of 15
Yes
Yes
Mmus\Eif4a3
2 of 15
No
No
Mmus\Gm8994
1 of 15
No
No
Rattus norvegicus (Norway rat) (3)
Rnor\Eif4a2
11 of 13
Yes
Yes
Rnor\Eif4a1
10 of 13
No
Yes
Rnor\Eif4a3
2 of 13
No
No
Xenopus tropicalis (Western clawed frog) (3)
Xtro\eif4a1
11 of 12
Yes
Yes
Xtro\eif4a2
10 of 12
No
Yes
Xtro\eif4a3
2 of 12
No
No
Danio rerio (Zebrafish) (4)
Drer\eif4a1a
10 of 15
Yes
Yes
Drer\eif4a1b
10 of 15
Yes
Yes
Drer\eif4a2
10 of 15
Yes
Yes
Drer\eif4a3
2 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (4)
Cele\inf-1
13 of 15
Yes
Yes
Cele\F57B9.3
5 of 15
No
Yes
Cele\F33D11.10
2 of 15
No
No
Cele\Y65B4A.6
2 of 15
No
No
Arabidopsis thaliana (thale-cress) (6)
Atha\EIF4A1
8 of 9
Yes
Yes
Atha\EIF4A-2
8 of 9
Yes
Yes
Atha\AT1G72730
7 of 9
No
Yes
Atha\AT1G51380
2 of 9
No
No
Atha\AT2G28600
1 of 9
No
Yes
Atha\EIF4A-III
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\TIF1
9 of 15
Yes
Yes
Scer\FAL1
4 of 15
No
No
Scer\TIF2
4 of 15
No
Yes
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\SPAC1006.07
8 of 12
Yes
Yes
Spom\SPAC1F5.10
1 of 12
No
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG0919097Y )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00009632
Drosophila simulans
Dsim\GD23375
Drosophila sechellia
Dsec\GM18587
Drosophila erecta
Dere\GG25110
Drosophila yakuba
Dyak\eIF-4a
Drosophila ananassae
Dana\GF15595
Drosophila pseudoobscura pseudoobscura
Dpse\GA21521
Drosophila persimilis
Dper\GL19047
Drosophila willistoni
Dwil\GK14711
Drosophila virilis
Dvir\GJ15436
Drosophila mojavensis
Dmoj\GI17537
Drosophila grimshawi
Dgri\GH11018
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091505KD )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17020772
Musca domestica
House fly
Mdoa\17016929
Glossina morsitans
Tsetse fly
Gmor\GMOY002522
Glossina morsitans
Tsetse fly
Gmor\GMOY003287
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_05212
Mayetiola destructor
Hessian fly
Mdes\Mdes006258
Mayetiola destructor
Hessian fly
Mdes\Mdes010974
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL013359
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL014414
Anopheles darlingi
American malaria mosquito
Adar\ADAC007455
Anopheles darlingi
American malaria mosquito
Adar\ADAC004044
Anopheles gambiae
Malaria mosquito
Agam\AGAP009863
Anopheles gambiae
Malaria mosquito
Agam\AGAP003089
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ001547
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W05FL )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA003186
Bombyx mori
Silkmoth
Bmor\BGIBMGA004822
Danaus plexippus
Monarch butterfly
Dple\DPOGS214941-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS211201-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL015594
Heliconius melpomene
Postman butterfly
Hmel\HMEL012453
Apis florea
Little honeybee
Aflo\2451681364
Apis florea
Little honeybee
Aflo\2198071780
Apis mellifera
Western honey bee
Amel\LOC409866
Apis mellifera
Western honey bee
Amel\GB51710
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP12462
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25120
Bombus terrestris
Buff-tailed bumblebee
Bter\15216784
Bombus terrestris
Buff-tailed bumblebee
Bter\15208217
Linepithema humile
Argentine ant
Lhum\LH11979
Linepithema humile
Argentine ant
Lhum\LH24849
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001e3b
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00103c
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG018524
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003545
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06329
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_04286
Tribolium castaneum
Red flour beetle
Tcas\TC014113
Tribolium castaneum
Red flour beetle
Tcas\TC009998
Pediculus humanus
Human body louse
Phum\PHUM148640
Pediculus humanus
Human body louse
Phum\PHUM597330
Rhodnius prolixus
Kissing bug
Rpro\RPRC006840
Rhodnius prolixus
Kissing bug
Rpro\RPRC002208
Cimex lectularius
Bed bug
Clec\CLEC005239
Cimex lectularius
Bed bug
Clec\CLEC008969
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001585
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002483
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_04200
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_04771
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X05BL )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR001486
Strigamia maritima
European centipede
Smar\SMAR009015
Strigamia maritima
European centipede
Smar\SMAR011862
Ixodes scapularis
Black-legged tick
Isca\ISCW015864
Ixodes scapularis
Black-legged tick
Isca\ISCW013399
Stegodyphus mimosarum
African social velvet spider
Smim\KFM68235.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM75183.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM78111.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM62051.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g09740
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g09690
Tetranychus urticae
Two-spotted spider mite
Turt\tetur21g02590
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_300157
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_104930
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_230663
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G07OI )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Eif4A
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ddx48
Ciona intestinalis
Vase tunicate
Cint\LOC100177596
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000007818
Gallus gallus
Domestic chicken
Ggal\EIF4A2
Gallus gallus
Domestic chicken
Ggal\EIF4A3
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (31)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG7483
4 of 10
abs
2 of 10
bel
2 of 10
CG5589
2 of 10
CG5800
2 of 10
CG6418
2 of 10
CG7878
2 of 10
CG8611
2 of 10
CG9143
2 of 10
CG9253
2 of 10
CG9630
2 of 10
CG10077
2 of 10
CG10333
2 of 10
CG14443
2 of 10
CG32344
2 of 10
Dbp21E2
2 of 10
Dbp45A
2 of 10
Dbp73D
2 of 10
Dbp80
2 of 10
Ddx1
2 of 10
Gem3
2 of 10
Hel25E
2 of 10
Hlc
2 of 10
mahe
2 of 10
me31B
2 of 10
pit
2 of 10
Prp5
2 of 10
Rm62
2 of 10
Rs1
2 of 10
vas
2 of 10
mus301
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    EIF4A1; eukaryotic translation initiation factor 4A1
    12 of 15
    602641
        EIF4A2; eukaryotic translation initiation factor 4A2
        12 of 15
        601102
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Show neighbor-neighbor interactions:
            Select Layout:
            Legend:
            Protein
            RNA
            Selected Interactor(s)
            Interactions Browser
            View in Interactions Browser
            Please see the Physical Interaction reports below for full details
            protein-protein
            Physical Interaction
            Assay
            References
            eIF4A - Akt
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            eIF4A - Mad
            anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, anti tag western blot, pull down
            (Li and Li, 2006)
            eIF4A - Med
            anti tag coimmunoprecipitation, anti tag western blot
            (Li and Li, 2006)
            eIF4A - NAT1
            anti tag coimmunoprecipitation, anti tag western blot, peptide massfingerprinting
            (Tsokanos et al., 2016)
            eIF4A - Pdcd4
            anti bait coimmunoprecipitation, western blot, anti tag western blot, pull down
            (Olson et al., 2013)
            eIF4A - Pdk1
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            eIF4A - Pi3K92E
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            eIF4A - Raf
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Friedman et al., 2011)
            eIF4A - RagC-D
            anti tag coimmunoprecipitation, anti tag western blot
            (Tsokanos et al., 2016)
            eIF4A - Rheb
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            eIF4A - S6k
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            eIF4A - S6kII
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            eIF4A - aub
            anti tag coimmunoprecipitation, anti tag western blot, cross-linking study, Identification by mass spectrometry
            (Ma et al., 2017, Zheng et al., 2016)
            eIF4A - bam
            anti tag coimmunoprecipitation, anti tag western blot, two hybrid
            (Shen et al., 2009)
            eIF4A - csw
            anti tag coimmunoprecipitation, peptide massfingerprinting
            (Friedman et al., 2011)
            eIF4A - eIF3b
            anti tag coimmunoprecipitation, western blot
            (Rode et al., 2018)
            eIF4A - eIF4G1
            two hybrid
            (Hernandez et al., 2004)
            eIF4A - gig
            anti tag coimmunoprecipitation, Identification by mass spectrometry, anti tag western blot
            (Tsokanos et al., 2016, Vinayagam et al., 2016)
            eIF4A - raptor
            anti tag coimmunoprecipitation, anti tag western blot
            (Tsokanos et al., 2016)
            eIF4A - rictor
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            eIF4A - sima
            anti tag coimmunoprecipitation, Identification by mass spectrometry
            (Vinayagam et al., 2016)
            eIF4A - tud
            anti tag coimmunoprecipitation, cross-linking study, Identification by mass spectrometry, anti bait coimmunoprecipitation, anti tag western blot
            (Zheng et al., 2016, Thomson et al., 2008)
            Summary of Genetic Interactions
            esyN Network Diagram
            esyN Network Key:
            Suppression
            Enhancement
            View in Interactions Browser
            Please look at the allele data for full details of the genetic interactions
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            eIF4A
            suppressible
            Dp
            (Galloni and Edgar, 1999)
            eIF4A
            suppressible
            E2f1
            (Galloni and Edgar, 1999)
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            bam
            enhanceable
            eIF4A
            (Shen et al., 2009)
            bam
            suppressible
            eIF4A
            (Shen et al., 2009)
            ct
            enhanceable
            eIF4A
            (Krupp et al., 2005)
            ct
            suppressible
            eIF4A
            (Krupp et al., 2005)
            dpp
            suppressible
            eIF4A
            (Li et al., 2005)
            Dref
            suppressible
            eIF4A
            (Ida et al., 2009, Ida et al., 2007)
            l(1)sc
            enhanceable
            eIF4A
            (Rottgen et al., 1998)
            N
            enhanceable
            eIF4A
            (Rottgen et al., 1998)
            Pdcd4
            suppressible
            eIF4A
            (Cash and Andrews, 2012)
            peb
            suppressible
            eIF4A
            (Wilk et al., 2004)
            Pten
            suppressible
            eIF4A
            (Gao et al., 2000)
            External Data
            Subunit Structure (UniProtKB)
            eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E1 and eIF4G1. Interacts with tud and vas.
            (UniProt, Q02748 )
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Pathways
            Signaling Pathways (FlyBase)
            Negative Regulators of BMP Signaling Pathway -
            Negative regulators of Bone Morphogenetic Protein (BMP) signaling down-regulate the pathway, ultimately resulting in the decreased nuclear activity of the Mad/Med transcription factor complex.
            Metabolic Pathways
            FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
            External Data
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            2L
            Recombination map
            2-18
            Cytogenetic map
            26B2-26B2
            Sequence location
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            26B2-26B2
            Limits computationally determined from genome sequence between P{EP}chicEP713&P{EP}chicEP1095 and P{lacW}Gef26k13720
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            25D5-26D1
            (Li and Gelbart, 2002)
            26B1-26B2
            (determined by in situ hybridisation)
            (Spradling et al., 1999)
            26A5-26A7
            26A5--8 26A7--8 26A7--9 26A8--9 26B1--2 26B8--9
            (BDGP Project Members, 1994-1999)
            26A7-26A9
            (determined by in situ hybridisation) 27A7--27A9 (determined by in situ hybridisation)
            (Dorn et al., 1993)
            Experimentally Determined Recombination Data
            Location

            2-18

            (FlyBase, 2016)

            2-19.2

            (Comeron et al., 2012)
            Left of (cM)
            (Li et al., 2005)
            Right of (cM)
            (Li et al., 2005)
            Notes
            Stocks and Reagents
            Stocks (22)
            Genomic Clones (18)
             

            Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

            cDNA Clones (908)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequenced
            BDGP DGC clones
            Other clones
            Drosophila Genomics Resource Center cDNA clones

            For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
            Other clones
            RNAi and Array Information
            Linkouts
            DRSC - Results frm RNAi screens
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            Antibody Information
            Laboratory Generated Antibodies
             

            polyclonal

            (Tsokanos et al., 2016, Fukaya et al., 2014, Olson et al., 2013, Hernandez et al., 2004)

            monoclonal

            (Na et al., 2016)
            Commercially Available Antibodies
             
            Other Information
            Relationship to Other Genes
            Source for database identify of

            Source for identity of: eIF4A eIF-4a

            (Marygold et al., 2017)
            Source for database merge of

            Source for merge of: eIF-4a l(2)k01501

            (Spradling et al., 1999)

            Source for merge of: eIF-4a Su(dpp)YE9

            (Li et al., 2005)
            Additional comments
            Other Comments

            RNAi screen using dsRNA made from templates generated with primers directed against this gene results in aberrantly short, monopolar spindles when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.

            (Goshima et al., 2007)

            S2 cells transfected with dsRNA made from templates generated with primers directed against this gene show significantly lower levels of global translation within 2 days.

            (Coelho et al., 2005)

            RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

            (Boutros et al., 2004)

            Identification: identified in a genetic screen for suppressors of the dppH46 phenotype.

            (Li and Gelbart, 2002)

            Maternal and zygotic suppressor of dppH46. Homozygous embryonic lethal. Cuticle phenotypes of homozygous mutant embryos show dorsal-ventral patterning defects. eIF-4a can completely rescue the maternal-effect lethality caused by Mad, sax double mutants.

            (Li and Gelbart, 2002)

            Identification: One of a collection of genes identified with defective larval growth that extend larval life.

            (Galloni and Edgar, 1999)

            Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland.

            (Harvie et al., 1998)

            Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology.

            (Roch et al., 1998)

            A single copy gene.

            (Dorn et al., 1993)

            1.6kb non-sex-specific transcript located close to Acp26Aa in the 26A region.

            (Monsma and Wolfner, 1988)
            Origin and Etymology
            Discoverer
            Etymology
            Identification
            External Crossreferences and Linkouts ( 86 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
            UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
            Other crossreferences
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
            GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            modMine - A data warehouse for the modENCODE project
            Linkouts
            ApoDroso - Functional genomic database for photoreceptor development, survival and function
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            FlyMine - An integrated database for Drosophila genomics
            KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Synonyms and Secondary IDs (40)
            Reported As
            Symbol Synonym
            2439
            (Harvie et al., 1998)
            9075
            (Ravi et al., 2009)
            CG9075
            (Vasudevan et al., 2020, Kolkhof et al., 2017, Marygold et al., 2017, Na et al., 2016, Hosono et al., 2015, Povellato et al., 2014, Schertel et al., 2013, Cammarato et al., 2011, Müller et al., 2010, Ni et al., 2010.12.1, Ida et al., 2009, Keleman et al., 2009.8.5, Ducat et al., 2008, Hughes et al., 2008, Goshima et al., 2007, Quinones-Coello, 2007, McIntyre et al., 2006, Molnar et al., 2006, Hernandez et al., 2004, Kraut et al., 2001, Kraut et al., 2001, Lasko, 2000, Whitfield, 2000.5.17)
            Dm-eIF4A
            (Hernandez et al., 2004)
            DmRH2
            (Boudet et al., 2001)
            EIF-4A
            (Hernandez et al., 2004, Boudet et al., 2001)
            EIF-4a
            (He et al., 2014, Povellato et al., 2014)
            EIF4A
            (Cui et al., 2020, Linsalata et al., 2019, Sofola et al., 2007)
            EiF4A
            (Weinkove and Leevers, 2000)
            Eif-4a
            (Morin et al., 2001)
            Eif4a
            (Nguyen et al., 2016)
            L(2L)162
            (Hernandez et al., 2004)
            Su(dpp)YE9
            (Li and Gelbart, 2002)
            anon-26Aa
            anon26A
            deIF4A
            (Gareau et al., 2013, Garrey et al., 2010)
            eIF 4A
            (Ducat et al., 2008)
            eIF-4A
            (Chen et al., 2013, Kent et al., 2009, Fuller and Baker, 2007.6.28, Beller et al., 2006, Takahashi et al., 2005, van Steensel et al., 2001)
            eIF-4a
            (Grobler et al., 2018, Jana et al., 2016, Na et al., 2016, Sarov et al., 2016, Tan et al., 2016, Dent et al., 2015, Tavares et al., 2015, Vedanayagam and Garrigan, 2015, Ashwal-Fluss et al., 2014, Lee et al., 2014, Bonke et al., 2013, Kwon et al., 2013, Schertel et al., 2013, Sen et al., 2013, Franco et al., 2011, Friedman et al., 2011, Müller et al., 2010, Müller et al., 2010, Ulvila et al., 2010, Ida et al., 2009, Jiang et al., 2009, Katzenberger et al., 2009, Maybeck and Röper, 2009, Fisher et al., 2008, Zhou et al., 2008, Buszczak et al., 2007, Goshima et al., 2007, Ida et al., 2007, Marygold et al., 2007, Quinones-Coello, 2007, Stuart et al., 2007, Sun et al., 2007, Christensen and Cook, 2006.8.29, McIntyre et al., 2006, Molnar et al., 2006, Lipatov et al., 2005, Wang et al., 2004)
            eIF-4a-I
            (Hernandez and Vazquez-Pianzola, 2005)
            eIF4A
            (Furusawa and Emoto, 2021, Millet-Boureima et al., 2021, Morin-Poulard et al., 2021, Jin et al., 2020, Thackray et al., 2020, Vasudevan et al., 2020, Drummond-Barbosa, 2019, Fingerhut et al., 2019, Rode et al., 2018, Ma et al., 2017, Marygold et al., 2017, Zheng et al., 2016, Tokusumi et al., 2015, Gareau et al., 2013, Hernández et al., 2013, Jagut et al., 2013, Olson et al., 2013, Cash and Andrews, 2012, Tokusumi et al., 2012, Singh et al., 2011, Park et al., 2010, Shen et al., 2009, Thomson et al., 2008, Andersen and Leevers, 2007, Franklin-Dumont et al., 2007, Ida et al., 2007, Bjorklund et al., 2006, Li and Li, 2006, Coelho et al., 2005, Li et al., 2005, Hernandez et al., 2004, Carrera et al., 2000, Lasko, 2000, Lehner, 1999, Verheyen and Cooley, 1994)
            eIF4A-I
            (Hernandez and Vazquez-Pianzola, 2005)
            eIF4AI
            (Palacios et al., 2004)
            eIF4a
            (Li et al., 2020, Ji et al., 2017, Olesnicky et al., 2014, Djiane et al., 2013, Blanco et al., 2010, Abel et al., 2009, Insco et al., 2009)
            eiF4A
            (Sankaranarayanan and Weil, 2020, Jagut et al., 2013)
            eif-4a
            (Basu and Li, 1998)
            eif4A
            (Orian et al., 2003, Gao et al., 2000, Galloni and Edgar, 1999, Galloni and Edgar, 1999)
            eif4a
            (Sofola et al., 2007)
            l(2)02439
            l(2)162
            l(2)26Ac
            l(2)gdh-4
            (Knipple and MacIntyre, 1984, Kotarski et al., 1983)
            l(2)k01501
            (BDGP Project Members, 1994-1999)
            l(2L)162
            (Dorn et al., 1993, Dorn, 1992.10.29)
            pecan
            (Jagut et al., 2013)
            Name Synonyms
            Eukaryotic initiation factor 4A
            (Costello et al., 2009)
            Eukaryotic initiation factor 4a
            (Cammarato et al., 2011)
            eukaryotic initiation factor 4A
            (Jagut et al., 2013, Ida et al., 2007)
            eukaryotic translation initiation factor 4A
            (Kent et al., 2009, Li and Li, 2006)
            translation initiation factor 4A
            (Hernandez et al., 2004)
            Secondary FlyBase IDs
            • FBgn0013406
            • FBgn0013523
            • FBgn0015864
            • FBgn0022247
            • FBgn0024969
            • FBgn0062252
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            References (204)