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Gene Dmel\eIF-4a

General Information
Symbol	Dmel\eIF-4a	Species	D. melanogaster
Name	Eukaryotic initiation factor 4a	Annotation symbol	CG9075
Feature type	protein_coding_gene	FlyBase ID	FBgn0001942
Gene Model Status	Current	Stock availability	19 publicly available
Also Known As	eIF4A, l(2L)162, l(2)gdh-4
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	26B2-26B2	Sequence location	2L:5,981,764..5,985,793 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Eukaryotic initiation factor 4a is referred to in FlyBase by the symbol Dmel\eIF-4a (CG9075, FBgn0001942). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: translation initiation factor activity; RNA helicase activity. There is experimental evidence that it is involved in the biological process: centrosome organization; germ-line stem cell maintenance; mitotic spindle elongation; response to DNA damage stimulus; mitosis; mitotic spindle organization; dorsal/ventral axis specification; oogenesis; female germ-line stem cell division; regulation of alternative mRNA splicing, via spliceosome. 67 alleles are reported. The phenotypes of these alleles are annotated with: multicellular structure; anatomical structure; parasegment; organ system; acellular anatomical structure; thoracic segment; parasegment 9; organ system subdivision; parasegment 14; parasegment 2; cephalopharyngeal skeleton; external compound sense organ; late extended germ band embryo. It has 6 annotated transcripts and 6 annotated polypeptides. Protein features are: DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Helicase, C-terminal; Helicase, superfamily 1/2, ATP-binding domain; RNA helicase, ATP-dependent, DEAD-box, conserved site; RNA helicase, DEAD-box type, Q motif. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very high expression. Peak expression observed within 00-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1638664_s_at completely aligns to an exonic region common to each of the 4 FlyBase-annotated transcript isoforms of eIF-4a. Gene sequence location is 2L:5981764..5985793.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 26B2-26B2   Limits computationally determined from genome sequence between P{EP}chicEP713&P{EP}chicEP1095 and P{lacW}Gef26k13720
Experimentally Determined Cytological Location
Cytogenetic map Notes References 25D5-26D1     (Li and Gelbart, 2002) 26B1-26B2   (determined by in situ hybridisation)   (Spradling et al., 1999) 26A5-26A7   26A5--8 26A7--8 26A7--9 26A8--9 26B1--2 26B8--9   (BDGP Project Members, 1994-1999) 26A7-26A9   (determined by in situ hybridisation) 27A7--27A9 (determined by in situ hybridisation)   (Dorn et al., 1993)
Experimentally Determined Recombination Data
Location
Left of (cM)	P{EP}CG13993EP570 P{EP}EP2273 P{lacW}l(2)k09923k09923 P{lacW}l(2)k09022k09022 P{lacW}hoipk07104 b P{lacW}l(2)k05404k05404 (Li et al., 2005)
Right of (cM)	P{lacW}vrik05901 P{EP}GpdhEP2304 P{lacW}l(2)k06502k06502 P{lacW}chick13321 dp (Li et al., 2005)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\eIF-4a for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.44 Low-frequency junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) eIF-4a-RA FBtr0079175  NM_164668   1691   403 eIF-4a-RB FBtr0079177  NM_164669   1847   403 eIF-4a-RC FBtr0079176  NM_057247   1553   403 eIF-4a-RD FBtr0079178  NM_164670   1729   403 eIF-4a-RE FBtr0307068  NM_001258978   1905   403 eIF-4a-RF FBtr0331201  NM_001273188   1939   403
Additional Transcript Data & Comments
Reported size (kB)	2.2, 2.0 (northern blot) (Cooley et al., 1992) 1.9, 1.75 (northern blot) (Dorn et al., 1993)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein eIF-4a-PA   FBpp0078806   45.9   403   5.34     NP_723137   AAF52317 eIF-4a-PB   FBpp0078808   45.9   403   5.34     NP_723138   AAN10567 eIF-4a-PC   FBpp0078807   45.9   403   5.34     NP_476595   AAN10566 eIF-4a-PD   FBpp0078809   45.9   403   5.34     NP_723139   AAN10568 eIF-4a-PE   FBpp0297911   45.9   403   5.34     NP_001245907   AFH03581 eIF-4a-PF   FBpp0303628   45.9   403   5.34     NP_001260117   AGB92653
Additional Polypeptide Data & Comments
Reported size (kDa)	402 (aa) (Dorn et al., 1993)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • RNA helicase, ATP-dependent, DEAD-box, conserved site (IPR000629) Helicase, C-terminal (IPR001650) DNA/RNA helicase, DEAD/DEAH box type, N-terminal (IPR011545) Helicase, superfamily 1/2, ATP-binding domain (IPR014001) RNA helicase, DEAD-box type, Q motif (IPR014014) P-loop containing nucleoside triphosphate hydrolase (IPR027417)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA201849   AA201904   AA202043   AA202058   AA202343   AA202523   AA202707   AA202885   AA202911   AA246225   AA246437   AA246506   AA247040   AA263702   AA263703   AA263740   AA264124   AA264232   AA264404   AA264540   AA390312   AA390330   AA390395   AA390651   AA390892   AA390978   AA391457   AA391976   AA392388   AA392501   AA438988   AA439755   AA439819   AA440183   AA440525   AA440932   AA441300   AA538657   AA539088   AA539371   AA539422   AA540050   AA540710   AA540831   AA567273   AA567376   AA567552   AA694788   AA694826   AA695516   AA695987   AA696353   AA696408   AA696520   AA697086   AA697222   AA697323   AA697431   AA697788   AA697802   AA697804   AA697829   AA698722   AA698991   AA735106   AA735346   AA735456   AA735836   AA735931   AA736007   AA801530   AA801735   AA801806   AA801846   AA801924   AA801960   AA802051   AA802692   AA802790   AA802848   AA803048   AA803391   AA803571   AA803621   AA803725   AA803938   AA804095   AA816632   AA816793   AA817113   AA817502   AA817518   AA817542   AA817603   AA820066   AA820379   AA820516   AA820578   AA820735   AA820837   AA820989   AA821083   AA821157   AA940905   AA940910   AA941322   AA941530   AA941537   AA941629   AA941652   AA941803   AA941848   AA942119   AA942175   AA942326   AA942422   AA942582   AA948909   AA948954   AA949207   AA949330   AA949362   AA949550   AA950096   AA950102   AA950248   AA950323   AA950469   AA950703   AA950705   AA950774   AA950787   AA950815   AA950975   AA951108   AA951316   AA951420   AA951579   AA951658   AA952057   AA952062   AA952073   AA952180   AA952215   AA978383   AA979078   AA979291   AA979421   AA979461   AA979576   AA979694   AA990658   AA990687   AA990720   AE014134 AAF52317   AE014134 AAN10566   AE014134 AAN10567   AE014134 AAN10568   AC004268   AC004758   AC092216   AF145621   AE014134 AFH03581   AE014134 AGB92653   AI061704   AI061711   AI061915   AI062172   AI062369   AI063589   AI063841   AI063866   AI064029   AI064134   AI064322   AI064349   AI064634   AI107476   AI107807   AI107939   AI107944   AI108482   AI108985   AI109126   AI109343   AI109863   AI109899   AI110001   AI110016   AI110100   AI113781   AI134236   AI135016   AI135037   AI135038   AI135102   AI135217   AI135282   AI135503   AI135863   AI135955   AI238013   AI238055   AI238740   AI239195   AI239240   AI256904   AI256945   AI256947   AI257797   AI257865   AI258675   AI258902   AI259001   AI259182   AI259519   AI259537   AI259627   AI259684   AI259819   AI260946   AI292660   AI292899   AI293339   AI293345   AI294031   AI294586   AI294644   AI295007   AI295189   AI295330   AI295501   AI295739   AI296519   AI296528   AI296984   AI297611   AI297752   AI297758   AI297920   AI386609   AI386755   AI386793   AI387126   AI387256   AI387384   AI387459   AI387542   AI387908   AI388091   AI388308   AI388517   AI388566   AI389089   AI389161   AI389181   AI389768   AI390013   AI401935   AI402580   AI402648   AI402695   AI402788   AI402872   AI402881   AI403056   AI403613   AI403763   AI403767   AI403866   AI403937   AI404035   AI404185   AI404296   AI404631   AI404825   AI405088   AI405101   AI405121   AI405804   AI405984   AI455576   AI455692   AI455860   AI455900   AI455903   AI455946   AI456053   AI456121   AI456170   AI456256   AI456436   AI456542   AI456865   AI456992   AI511681   AI511720   AI511847   AI511854   AI511894   AI511916   AI511949   AI512336   AI513039   AI513172   AI513594   AI513827   AI513897   AI514346   AI514639   AI514658   AI514665   AI514820   AI514916   AI515014   AI515346   AI515439   AI515707   AI516090   AI516181   AI516208   AI516436   AI516586   AI516744   AI517545   AI517610   AI517656   AI517781   AI517937   AI518149   AI518156   AI518281   AI518553   AI518885   AI519083   AI519302   AI519304   AI519336   AI519603   AI519625   AI519662   AI519777   AI519858   AI519953   AI520072   AI520193   AI520401   AI520550   AI520607   AI530758   AI531392   AI532265   AI532352   AI533040   AI533082   AI533253   AI533477   AI533658   AI533932   AI534660   AI534672   AI534818   AI541697   AI541802   AI542059   AI543567   AI543579   AI543662   AI543867   AI544052   AI544135   AI544251   AI544423   AI546190   AI546237   AI546595   AI946230   AQ034134   AQ072952   AQ254819   AW940665   AW941379   AY069283 AAL39428   AY121623 AAM51950   AY231884   AY432777   AZ300927   BF486337   BF488184   BF490989   BF491956   BF492258   BF493547   BF493813   BF494487   BF495494   BF495981   BF495995   BF498616   BF498763   BF500204   BF502952   BF504480   BF504588   BF506100   BG632744   BG633143   BG633490   BG635575   BG635593   BG636086   BG636413   BG636515   BG636835   BG637023   BG637058   BG637137   BG637273   BG639085   BG639104   BG640653   BG640730   BG640756   BG640913   BG641046   BG641139   BG641248   BG641334   BG641441   BI142037   BI162629   BI162630   BI163868   BI164604   BI164921   BI166446   BI166589   BI167402   BI167463   BI168905   BI171956   BI172580   BI173033   BI173309   BI173674   BI213443   BI215294   BI216063   BI216233   BI227825   BI227972   BI228479   BI228847   BI229900   BI229930   BI230987   BI232064   BI234750   BI235330   BI235557   BI235732   BI237130   BI237440   BI237749   BI238307   BI240350   BI241263   BI241268   BI241763   BI243664   BI351654   BI353897   BI354228   BI354265   BI354319   BI354360   BI354363   BI354369   BI354379   BI354382   BI354396   BI355576   BI357181   BI358064   BI358135   BI358617   BI358622   BI358678   BI358682   BI358706   BI358710   BI358714   BI361873   BI362240   BI362292   BI363004   BI364133   BI364233   BI365815   BI366978   BI367464   BI371952   BI372414   BI372999   BI373536   BI373769   BI374556   BI374719   BI375195   BI375233   BI375401   BI483799   BI483819   BI485875   BI563541   BI564275   BI564326   BI564480   BI564558   BI564562   BI564738   BI565578   BI566135   BI566145   BI566240   BI566532   BI566659   BI566865   BI567443   BI567503   BI567693   BI567891   BI567907   BI567925   BI568140   BI568319   BI568335   BI568512   BI568690   BI568695   BI572198   BI572200   BI574324   BI574450   BI574754   BI574793   BI574923   BI574939   BI574969   BI574999   BI575860   BI576173   BI576364   BI576992   BI578703   BI582207   BI582209   BI582333   BI582381   BI582627   BI583042   BI583229   BI583969   BI584102   BI584216   BI584561   BI584647   BI584744   BI585897   BI586108   BI586175   BI586723   BI586832   BI587093   BI587707   BI587748   BI587886   BI587912   BI587929   BI588583   BI588988   BI589081   BI589189   BI589221   BI591144   BI591496   BI591706   BI592323   BI592346   BI592653   BI593241   BI604837   BI605145   BI605201   BI605207   BI605361   BI605512   BI605813   BI605884   BI606481   BI606726   BI607140   BI607236   BI607368   BI607561   BI607990   BI608288   BI608807   BI609232   BI610401   BI610431   BI610634   BI610659   BI610685   BI611136   BI611199   BI611538   BI611776   BI613088   BI613528   BI613840   BI613891   BI613916   BI614101   BI614226   BI614240   BI614291   BI614365   BI614383   BI615357   BI615713   BI615767   BI615866   BI615996   BI616679   BI617226   BI617802   BI618531   BI618656   BI619041   BI619122   BI619233   BI619550   BI619591   BI619866   BI620020   BI620283   BI620934   BI621166   BI621232   BI621714   BI621799   BI624220   BI624485   BI624542   BI624577   BI624583   BI624584   BI625255   BI625545   BI625688   BI625790   BI625809   BI625825   BI626113   BI626307   BI626761   BI627759   BI627989   BI628189   BI628301   BI628321   BI628969   BI629606   BI629687   BI629852   BI629911   BI630159   BI631290   BI631596   BI631606   BI631779   BI631787   BI632366   BI632492   BI632587   BI632603   BI632879   BI633043   BI633060   BI633181   BI633212   BI633432   BI633622   BI634043   BI634084   BI634094   BI634370   BI634571   BI634691   BI634698   BI634729   BI634766   BI634829   BI634970   BI635006   BI635184   BI636070   BI636220   BI636496   BI636811   BI637113   BI637124   BI637267   BI637292   BI637789   BI637891   BI638258   BI638348   BI639250   BI639421   BI639646   BI639750   BI640201   BI640474   BI640499   BI640539   BI640575   BI641106   BI641165   BI641233   BP540548   BP540549   BP541849   BP542219   BP542274   BP543180   BP543594   BP543595   BP545481   BP545482   BP547465   BP547827   BP547862   BP548040   BP548496   BP550187   BP550225   BP550226   BP551920   BP551921   BP552750   BP552751   BP554520   BP554521   BP554785   BP555793   BP557623   BP557624   BP558284   BP558285   BP558639   BP558640   BQ102860   BQ102959   BQ103082   BQ103234   BQ103367   BQ103658   BT099779   BT099924   BT120047   BX005606   BX005820   BX006051   BX006591   BX006799   BX006954   BX006999   BX007641   BX007972   BX008146   BX010574   BX011159   BX012073   BX012351   BX012571   BX013059   BX013936   BX014494   BX014549   BX014704   BX014949   BX016087   BX016259   BX016786   BX017198   BX018863   BX019527   BX019824   BX020351   BX020449   BX020719   BX020935   BX021157   BX022334   BX022395   BX022764   BX022817   BX023785   BX025017   BX025026   BX025155   BX025946   BX026426   BX026857   BX027281   BX027399   BX027600   BX027809   BX028052   BX028815   BX029055   BX029783   BX029860   BX029878   BX030041   BX031050   BX031808   BX032130   BX032923   BX033620   BX034342   BX034458   BX034606   BX036204   BX036646   BX036785   BX036939   BX037317   BX037323   BX039495   BX041311   BX041913   BX041931   BX042603   BX042800   BX043775   BX045526   BX045848   BX046370   BX046997   BX047008   BX048646   BX048874   BX051891   BX053902   BX054982   BX055207   BX056399   BX056578   BX056992   BX057121   BX057129   BX057996   BX059384   BX059457   BX059693   BX059729   BX060562   BX060628   BX060824   BX061963   BX062000   BX062173   BX063716   BX063776   BX064751   BX065077   BX065405   BX065543   BX068798   BX068965   BX069140   BX071670   BX071862   CA803673   CA803711   CA804164   CA804670   CA804776   CA805823   CA806990   CA807763   CA807851   CK086555   CK131608   CK131823   CK131832   CK131946   CK132065   CK132126   CK132140   CK132236   CK132397   CK656984   CK657116   CK657508   CK657740   CK658069   CK658151   CK658578   CK658689   CK659290   CK659438   CK659441   CK659473   CK659645   CK659801   CK660543   CK660632   CK660848   CK661153   CK661219   CK661335   CK662118   CO153226   CO153581   CO154146   CO154469   CO155359   CO155695   CO155882   CO156052   CO156827   CO178318   CO181582   CO182540   CO183143   CO190897   CO193681   CO264231   CO276050   CO281356   CO284683   CO285447   CO291865   CO303746   CO312873   CO316657   CO317991   CO318098   CO325793   CO326237   CO328058   CO328293   CO330756   CO332439   CO335710   CO335832   CO336026   CO336452   CO337129   CO337184   CO337285   CO338245   CO338821   CO339831   CZ475160   DN154319   DQ440212   EC055061   EC055108   EC055548   EC055963   EC060672   EC061120   EC061966   EC061983   EC063533   EC065075   EC069366   EC074092   EC074720   EC074937   EC081138   EC202290   EC204267   EC207036   EC213250   EC216352   EC221666   EC226134   EC239744   EC241307   EC242919   EC246947   EC250024   EC252877   EC258699   EC260222   EC260809   EC260880   EC261441   EC261519   EC261639   EC261827   EC263205   EC263361   EC263862   EC263904   EC263946   EC265726   EC266257   EC266328   EC266803   EC267728   EL870065   EL870066   EL871395   EL871396   EL873614   EL873615   EL873703   EL873811   EL873812   EL873910   EL876160   EL876161   EL876555   EL876776   EL877027   EL878970   EL878971   EL879041   EL879042   EL879072   EL879073   EL879112   EL879165   EL879166   EL879689   EL879810   EL879939   EL879940   EL880077   EL882137   EL882529   ES691485   ES691495   ES691518   ES691526   ES691952   ES691959   ES691961   ES692326   EU930205   EV576379   EV576870   EV578307   EV581477   EV586945   EV587577   EV588539   EV589324   EV591470   EV592870   EV593150   EV594274   EV595095   EV596328   EV599636   EV599780   EV600180   G01428   GH942141   GH946618   GH946666   GH947525   GH949374   GH949509   GH950629   GH951891   GH953036   GH954036   GH955175   GH955704   GH956556   GH958485   GH958521   GH959404   GH960460   GH961178   GH961550   GH963973   GH966052   GH966325   GH966535   GH968129   GH968162   GH968611   GH973214   GH974229   GH975361   GH975479   GH978909   GH980066   GH980980   GH981993   GH982092   GH982200   GH983388   X69045 CAA48790
UniProtKB/Swiss-Prot	Q02748
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References regulatory region FBsf0000435512 2L:5,981,378..5,981,759 evidence=Reporter construct (in vivo) (Ida et al., 2007, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | ubiquitous & uniform   (Hernandez et al., 2004) embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | ubiquitous   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | ubiquitous   (Dorn et al., 1993) embryonic stage -- adult stage     (Dorn et al., 1993) organism   (Hernandez et al., 2004)
Additional Descriptive Data
	eIF-4a transcripts are detected at all developmental stages. In embryos, they are already present in large amounts in fertilized eggs and are abundant in all tissues at later stages of development. (Dorn et al., 1993)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | ubiquitous & uniform   (Hernandez et al., 2004) embryonic stage 5   organism   • apical cortex (Hernandez et al., 2004) third instar larval stage   wing disc | ubiquitous & uniform   (Hernandez et al., 2004) haltere disc | ubiquitous & uniform   (Hernandez et al., 2004) ventral thoracic disc | ubiquitous & uniform   (Hernandez et al., 2004) eye-antennal disc | ubiquitous & uniform   (Hernandez et al., 2004) mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
	eIF-4a protein is ubiquitously distributed at all embryonic stages. In cellular blastoderms, protein is significantly accumulated in the apical cortex of blastoderm cells. eIF-4a protein is evenly distributed in wing, haltere, leg, and eye-antennal discs. (Hernandez et al., 2004)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
centrosome inferred from direct assay (Müller et al., 2010) microtubule associated complex inferred from direct assay (Hughes et al., 2008) mitotic spindle inferred from direct assay (Müller et al., 2010)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2615.7 Larval Midgut    3780.1 Larval Hindgut    3810.4 Larval Malpighian Tubules    4102.7 Larval Fat Body    5477.5 Larval Salivary Gland    6080.1 Larval Trachea    3528 Larval Carcass    3864.55 Adult Head    3607.8 Adult Eye    4196.025 Adult Brain    3005.3 Adult Thoracic-Abdominal Ganglion    3503.8 Adult Crop    3985.6 Adult Midgut    3541.4 Adult Hindgut    3746 Adult Malpighian Tubules    4480.9 Adult Fat Body    4964.1 Adult Salivary Gland    7727.6 Adult Heart    4465.3 Adult VirginFemale Spermatheca    4423.2 Adult InseminatedFemale Spermatheca    4488.3 Adult Ovary    2631.7 Adult Testis    1529 Adult Male Accessory Gland    6215 Adult Carcass    4088.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2615.7) Larval Midgut  (3780.1) Larval Hindgut  (3810.4) Larval Malpighian Tubules  (4102.7) Larval Fat Body  (5477.5) Larval Salivary Gland  (6080.1) Larval Trachea  (3528) Larval Carcass  (3864.55) Adult Head  (3607.8) Adult Eye  (4196.025) Adult Brain  (3005.3) Adult Thoracic-Abdominal Ganglion  (3503.8) Adult Crop  (3985.6) Adult Midgut  (3541.4) Adult Hindgut  (3746) Adult Malpighian Tubules  (4480.9) Adult Fat Body  (4964.1) Adult Salivary Gland  (7727.6) Adult Heart  (4465.3) Adult VirginFemale Spermatheca  (4423.2) Adult InseminatedFemale Spermatheca  (4488.3) Adult Ovary  (2631.7) Adult Testis  (1529) Adult Male Accessory Gland  (6215) Adult Carcass  (4088.3) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2615.7) Larval Midgut  (3780.1) Larval Hindgut  (3810.4) Larval Malpighian Tubules  (4102.7) Larval Fat Body  (5477.5) Larval Salivary Gland  (6080.1) Larval Trachea  (3528) Larval Carcass  (3864.55) Adult Head  (3607.8) Adult Eye  (4196.025) Adult Brain  (3005.3) Adult Thoracic-Abdominal Ganglion  (3503.8) Adult Crop  (3985.6) Adult Midgut  (3541.4) Adult Hindgut  (3746) Adult Malpighian Tubules  (4480.9) Adult Fat Body  (4964.1) Adult Salivary Gland  (7727.6) Adult Heart  (4465.3) Adult VirginFemale Spermatheca  (4423.2) Adult InseminatedFemale Spermatheca  (4488.3) Adult Ovary  (2631.7) Adult Testis  (1529) Adult Male Accessory Gland  (6215) Adult Carcass  (4088.3) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2615.7 Larval Midgut    3780.1 Larval Hindgut    3810.4 Larval Malpighian Tubules    4102.7 Larval Fat Body    5477.5 Larval Salivary Gland    6080.1 Larval Trachea    3528 Larval Carcass    3864.55 Adult Head    3607.8 Adult Eye    4196.025 Adult Brain    3005.3 Adult Thoracic-Abdominal Ganglion    3503.8 Adult Crop    3985.6 Adult Midgut    3541.4 Adult Hindgut    3746 Adult Malpighian Tubules    4480.9 Adult Fat Body    4964.1 Adult Salivary Gland    7727.6 Adult Heart    4465.3 Adult VirginFemale Spermatheca    4423.2 Adult InseminatedFemale Spermatheca    4488.3 Adult Ovary    2631.7 Adult Testis    1529 Adult Male Accessory Gland    6215 Adult Carcass    4088.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2615.7 Larval Midgut    3780.1 Larval Hindgut    3810.4 Larval Malpighian Tubules    4102.7 Larval Fat Body    5477.5 Larval Salivary Gland    6080.1 Larval Trachea    3528 Larval Carcass    3864.55 Adult Head    3607.8 Adult Eye    4196.025 Adult Brain    3005.3 Adult Thoracic-Abdominal Ganglion    3503.8 Adult Crop    3985.6 Adult Midgut    3541.4 Adult Hindgut    3746 Adult Malpighian Tubules    4480.9 Adult Fat Body    4964.1 Adult Salivary Gland    7727.6 Adult Heart    4465.3 Adult VirginFemale Spermatheca    4423.2 Adult InseminatedFemale Spermatheca    4488.3 Adult Ovary    2631.7 Adult Testis    1529 Adult Male Accessory Gland    6215 Adult Carcass    4088.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (2615.7) Larval Midgut  (3780.1) Larval Hindgut  (3810.4) Larval Malpighian Tubules  (4102.7) Larval Fat Body  (5477.5) Larval Salivary Gland  (6080.1) Larval Trachea  (3528) Larval Carcass  (3864.55) Adult Head  (3607.8) Adult Eye  (4196.025) Adult Brain  (3005.3) Adult Thoracic-Abdominal Ganglion  (3503.8) Adult Crop  (3985.6) Adult Midgut  (3541.4) Adult Hindgut  (3746) Adult Malpighian Tubules  (4480.9) Adult Fat Body  (4964.1) Adult Salivary Gland  (7727.6) Adult Heart  (4465.3) Adult VirginFemale Spermatheca  (4423.2) Adult InseminatedFemale Spermatheca  (4488.3) Adult Ovary  (2631.7) Adult Testis  (1529) Adult Male Accessory Gland  (6215) Adult Carcass  (4088.3) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (2615.7) Larval Midgut  (3780.1) Larval Hindgut  (3810.4) Larval Malpighian Tubules  (4102.7) Larval Fat Body  (5477.5) Larval Salivary Gland  (6080.1) Larval Trachea  (3528) Larval Carcass  (3864.55) Adult Head  (3607.8) Adult Eye  (4196.025) Adult Brain  (3005.3) Adult Thoracic-Abdominal Ganglion  (3503.8) Adult Crop  (3985.6) Adult Midgut  (3541.4) Adult Hindgut  (3746) Adult Malpighian Tubules  (4480.9) Adult Fat Body  (4964.1) Adult Salivary Gland  (7727.6) Adult Heart  (4465.3) Adult VirginFemale Spermatheca  (4423.2) Adult InseminatedFemale Spermatheca  (4488.3) Adult Ovary  (2631.7) Adult Testis  1529 Adult Male Accessory Gland  (6215) Adult Carcass  (4088.3) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2615.7 Larval Midgut    3780.1 Larval Hindgut    3810.4 Larval Malpighian Tubules    4102.7 Larval Fat Body    5477.5 Larval Salivary Gland    6080.1 Larval Trachea    3528 Larval Carcass    3864.55 Adult Head    3607.8 Adult Eye    4196.025 Adult Brain    3005.3 Adult Thoracic-Abdominal Ganglion    3503.8 Adult Crop    3985.6 Adult Midgut    3541.4 Adult Hindgut    3746 Adult Malpighian Tubules    4480.9 Adult Fat Body    4964.1 Adult Salivary Gland    7727.6 Adult Heart    4465.3 Adult VirginFemale Spermatheca    4423.2 Adult InseminatedFemale Spermatheca    4488.3 Adult Ovary    2631.7 Adult Testis    1529 Adult Male Accessory Gland    6215 Adult Carcass    4088.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    3607.8   NA  Eye    4196.025   NA  Brain    3005.3   2615.7  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    3503.8   NA  Crop    3985.6   3780.1  Midgut    3541.4   3810.4  Hindgut    3746   4102.7  Malpighian Tubules    4480.9   5477.5  Fat Body    4964.1   6080.1  Salivary Gland    7727.6   NA  Heart    4465.3   3528  Trachea    NA   NA  VirginFemale Spermatheca    4423.2   NA  InseminatedFemale Spermatheca    4488.3   NA  Ovary    2631.7   NA  Testis    1529   NA  Male Accessory Gland    6215   3864.55  Carcass    4088.3 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    720 central nervous system, larvae L3    919 central nervous system, pupae P8    581 head, virgin 1-day female    461 head, virgin 4-day female    743 head, virgin 20-day female    495 head, mated 1-day female    534 head, mated 4-day female    554 head, mated 20-day female    475 head, mated 1-day male    585 head, mated 4-day male    661 head, mated 20-day male    589 salivary gland, larvae L3 wandering    322 salivary gland, white prepupae    1430 digestive system, larvae L3 wandering    639 digestive system, 1-day adult    340 digestive system, 4-day adult    412 digestive system, 20-day adult    327 fat body, larvae L3 wandering    405 fat body, white prepupae    460 fat body, pupae P8    1403 carcass, larvae L3 wandering    867 carcass, 1-day adult    360 carcass, 4-day adult    474 carcass, 20-day adult    553 ovary, virgin 4-day female    607 ovary, mated 4-day female    530 testis, mated 4-day male    433 accessory gland, mated 4-day male    555 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (720) central nervous system, larvae L3  (919) central nervous system, pupae P8  (581) head, virgin 1-day female  (461) head, virgin 4-day female  (743) head, virgin 20-day female  (495) head, mated 1-day female  (534) head, mated 4-day female  (554) head, mated 20-day female  (475) head, mated 1-day male  (585) head, mated 4-day male  (661) head, mated 20-day male  (589) salivary gland, larvae L3 wandering  (322) salivary gland, white prepupae  (1430) digestive system, larvae L3 wandering  (639) digestive system, 1-day adult  (340) digestive system, 4-day adult  (412) digestive system, 20-day adult  (327) fat body, larvae L3 wandering  (405) fat body, white prepupae  (460) fat body, pupae P8  (1403) carcass, larvae L3 wandering  (867) carcass, 1-day adult  (360) carcass, 4-day adult  (474) carcass, 20-day adult  (553) ovary, virgin 4-day female  (607) ovary, mated 4-day female  (530) testis, mated 4-day male  (433) accessory gland, mated 4-day male  (555) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (720) central nervous system, larvae L3  (919) central nervous system, pupae P8  (581) head, virgin 1-day female  (461) head, virgin 4-day female  (743) head, virgin 20-day female  (495) head, mated 1-day female  (534) head, mated 4-day female  (554) head, mated 20-day female  (475) head, mated 1-day male  (585) head, mated 4-day male  (661) head, mated 20-day male  (589) salivary gland, larvae L3 wandering  (322) salivary gland, white prepupae  (1430) digestive system, larvae L3 wandering  (639) digestive system, 1-day adult  (340) digestive system, 4-day adult  (412) digestive system, 20-day adult  (327) fat body, larvae L3 wandering  (405) fat body, white prepupae  (460) fat body, pupae P8  (1403) carcass, larvae L3 wandering  (867) carcass, 1-day adult  (360) carcass, 4-day adult  (474) carcass, 20-day adult  (553) ovary, virgin 4-day female  (607) ovary, mated 4-day female  (530) testis, mated 4-day male  (433) accessory gland, mated 4-day male  (555) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    720 central nervous system, larvae L3    919 central nervous system, pupae P8    581 head, virgin 1-day female    461 head, virgin 4-day female    743 head, virgin 20-day female    495 head, mated 1-day female    534 head, mated 4-day female    554 head, mated 20-day female    475 head, mated 1-day male    585 head, mated 4-day male    661 head, mated 20-day male    589 salivary gland, larvae L3 wandering    322 salivary gland, white prepupae    1430 digestive system, larvae L3 wandering    639 digestive system, 1-day adult    340 digestive system, 4-day adult    412 digestive system, 20-day adult    327 fat body, larvae L3 wandering    405 fat body, white prepupae    460 fat body, pupae P8    1403 carcass, larvae L3 wandering    867 carcass, 1-day adult    360 carcass, 4-day adult    474 carcass, 20-day adult    553 ovary, virgin 4-day female    607 ovary, mated 4-day female    530 testis, mated 4-day male    433 accessory gland, mated 4-day male    555 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    720 central nervous system, larvae L3    919 central nervous system, pupae P8    581 head, virgin 1-day female    461 head, virgin 4-day female    743 head, virgin 20-day female    495 head, mated 1-day female    534 head, mated 4-day female    554 head, mated 20-day female    475 head, mated 1-day male    585 head, mated 4-day male    661 head, mated 20-day male    589 salivary gland, larvae L3 wandering    322 salivary gland, white prepupae    1430 digestive system, larvae L3 wandering    639 digestive system, 1-day adult    340 digestive system, 4-day adult    412 digestive system, 20-day adult    327 fat body, larvae L3 wandering    405 fat body, white prepupae    460 fat body, pupae P8    1403 carcass, larvae L3 wandering    867 carcass, 1-day adult    360 carcass, 4-day adult    474 carcass, 20-day adult    553 ovary, virgin 4-day female    607 ovary, mated 4-day female    530 testis, mated 4-day male    433 accessory gland, mated 4-day male    555 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (720) central nervous system, larvae L3  (919) central nervous system, pupae P8  (581) head, virgin 1-day female  (461) head, virgin 4-day female  (743) head, virgin 20-day female  (495) head, mated 1-day female  (534) head, mated 4-day female  (554) head, mated 20-day female  (475) head, mated 1-day male  (585) head, mated 4-day male  (661) head, mated 20-day male  (589) salivary gland, larvae L3 wandering  (322) salivary gland, white prepupae  (1430) digestive system, larvae L3 wandering  (639) digestive system, 1-day adult  (340) digestive system, 4-day adult  (412) digestive system, 20-day adult  (327) fat body, larvae L3 wandering  (405) fat body, white prepupae  (460) fat body, pupae P8  (1403) carcass, larvae L3 wandering  (867) carcass, 1-day adult  (360) carcass, 4-day adult  (474) carcass, 20-day adult  (553) ovary, virgin 4-day female  (607) ovary, mated 4-day female  (530) testis, mated 4-day male  (433) accessory gland, mated 4-day male  (555) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (720) central nervous system, larvae L3  (919) central nervous system, pupae P8  (581) head, virgin 1-day female  (461) head, virgin 4-day female  (743) head, virgin 20-day female  (495) head, mated 1-day female  (534) head, mated 4-day female  (554) head, mated 20-day female  (475) head, mated 1-day male  (585) head, mated 4-day male  (661) head, mated 20-day male  (589) salivary gland, larvae L3 wandering  (322) salivary gland, white prepupae  (1430) digestive system, larvae L3 wandering  (639) digestive system, 1-day adult  (340) digestive system, 4-day adult  (412) digestive system, 20-day adult  (327) fat body, larvae L3 wandering  (405) fat body, white prepupae  (460) fat body, pupae P8  (1403) carcass, larvae L3 wandering  (867) carcass, 1-day adult  (360) carcass, 4-day adult  (474) carcass, 20-day adult  (553) ovary, virgin 4-day female  (607) ovary, mated 4-day female  (530) testis, mated 4-day male  (433) accessory gland, mated 4-day male  (555) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    720 central nervous system, larvae L3    919 central nervous system, pupae P8    581 head, virgin 1-day female    461 head, virgin 4-day female    743 head, virgin 20-day female    495 head, mated 1-day female    534 head, mated 4-day female    554 head, mated 20-day female    475 head, mated 1-day male    585 head, mated 4-day male    661 head, mated 20-day male    589 salivary gland, larvae L3 wandering    322 salivary gland, white prepupae    1430 digestive system, larvae L3 wandering    639 digestive system, 1-day adult    340 digestive system, 4-day adult    412 digestive system, 20-day adult    327 fat body, larvae L3 wandering    405 fat body, white prepupae    460 fat body, pupae P8    1403 carcass, larvae L3 wandering    867 carcass, 1-day adult    360 carcass, 4-day adult    474 carcass, 20-day adult    553 ovary, virgin 4-day female    607 ovary, mated 4-day female    530 testis, mated 4-day male    433 accessory gland, mated 4-day male    555 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of very high expression. Peak expression observed within 00-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    885 embryo 02-04hr    1492 embryo 04-06hr    1659 embryo 06-08hr    1670 embryo 08-10hr    1760 embryo 10-12hr    1904 embryo 12-14hr    1129 embryo 14-16hr    1383 embryo 16-18hr    1219 embryo 18-20hr    1152 embryo 20-22hr    1202 embryo 22-24hr    1084 larva L1    1224 larva L2    847 larva L3 12hr old    715 larva L3 puffstage 1-2    666 larva L3 puffstage 3-6    792 larva L3 puffstage 7-9    967 white prepupae new    966 white prepupae 12hr    1094 white prepupae 24hr    944 pupae 2d postWPP    807 pupae 3d postWPP    592 pupae 4d postWPP    792 adult male 01day    581 adult male 05day    631 adult male 30day    671 adult female 01day    989 adult female 05day    795 adult female 30day    836 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (885) embryo 02-04hr  (1492) embryo 04-06hr  (1659) embryo 06-08hr  (1670) embryo 08-10hr  (1760) embryo 10-12hr  (1904) embryo 12-14hr  (1129) embryo 14-16hr  (1383) embryo 16-18hr  (1219) embryo 18-20hr  (1152) embryo 20-22hr  (1202) embryo 22-24hr  (1084) larva L1  (1224) larva L2  (847) larva L3 12hr old  (715) larva L3 puffstage 1-2  (666) larva L3 puffstage 3-6  (792) larva L3 puffstage 7-9  (967) white prepupae new  (966) white prepupae 12hr  (1094) white prepupae 24hr  (944) pupae 2d postWPP  (807) pupae 3d postWPP  (592) pupae 4d postWPP  (792) adult male 01day  (581) adult male 05day  (631) adult male 30day  (671) adult female 01day  (989) adult female 05day  (795) adult female 30day  (836) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (885) embryo 02-04hr  (1492) embryo 04-06hr  (1659) embryo 06-08hr  (1670) embryo 08-10hr  (1760) embryo 10-12hr  (1904) embryo 12-14hr  (1129) embryo 14-16hr  (1383) embryo 16-18hr  (1219) embryo 18-20hr  (1152) embryo 20-22hr  (1202) embryo 22-24hr  (1084) larva L1  (1224) larva L2  (847) larva L3 12hr old  (715) larva L3 puffstage 1-2  (666) larva L3 puffstage 3-6  (792) larva L3 puffstage 7-9  (967) white prepupae new  (966) white prepupae 12hr  (1094) white prepupae 24hr  (944) pupae 2d postWPP  (807) pupae 3d postWPP  (592) pupae 4d postWPP  (792) adult male 01day  (581) adult male 05day  (631) adult male 30day  (671) adult female 01day  (989) adult female 05day  (795) adult female 30day  (836) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    885 embryo 02-04hr    1492 embryo 04-06hr    1659 embryo 06-08hr    1670 embryo 08-10hr    1760 embryo 10-12hr    1904 embryo 12-14hr    1129 embryo 14-16hr    1383 embryo 16-18hr    1219 embryo 18-20hr    1152 embryo 20-22hr    1202 embryo 22-24hr    1084 larva L1    1224 larva L2    847 larva L3 12hr old    715 larva L3 puffstage 1-2    666 larva L3 puffstage 3-6    792 larva L3 puffstage 7-9    967 white prepupae new    966 white prepupae 12hr    1094 white prepupae 24hr    944 pupae 2d postWPP    807 pupae 3d postWPP    592 pupae 4d postWPP    792 adult male 01day    581 adult male 05day    631 adult male 30day    671 adult female 01day    989 adult female 05day    795 adult female 30day    836 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    885 embryo 02-04hr    1492 embryo 04-06hr    1659 embryo 06-08hr    1670 embryo 08-10hr    1760 embryo 10-12hr    1904 embryo 12-14hr    1129 embryo 14-16hr    1383 embryo 16-18hr    1219 embryo 18-20hr    1152 embryo 20-22hr    1202 embryo 22-24hr    1084 larva L1    1224 larva L2    847 larva L3 12hr old    715 larva L3 puffstage 1-2    666 larva L3 puffstage 3-6    792 larva L3 puffstage 7-9    967 white prepupae new    966 white prepupae 12hr    1094 white prepupae 24hr    944 pupae 2d postWPP    807 pupae 3d postWPP    592 pupae 4d postWPP    792 adult male 01day    581 adult male 05day    631 adult male 30day    671 adult female 01day    989 adult female 05day    795 adult female 30day    836 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (885) embryo 02-04hr  (1492) embryo 04-06hr  (1659) embryo 06-08hr  (1670) embryo 08-10hr  (1760) embryo 10-12hr  (1904) embryo 12-14hr  (1129) embryo 14-16hr  (1383) embryo 16-18hr  (1219) embryo 18-20hr  (1152) embryo 20-22hr  (1202) embryo 22-24hr  (1084) larva L1  (1224) larva L2  (847) larva L3 12hr old  (715) larva L3 puffstage 1-2  (666) larva L3 puffstage 3-6  (792) larva L3 puffstage 7-9  (967) white prepupae new  (966) white prepupae 12hr  (1094) white prepupae 24hr  (944) pupae 2d postWPP  (807) pupae 3d postWPP  (592) pupae 4d postWPP  (792) adult male 01day  (581) adult male 05day  (631) adult male 30day  (671) adult female 01day  (989) adult female 05day  (795) adult female 30day  (836) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (885) embryo 02-04hr  (1492) embryo 04-06hr  (1659) embryo 06-08hr  (1670) embryo 08-10hr  (1760) embryo 10-12hr  (1904) embryo 12-14hr  (1129) embryo 14-16hr  (1383) embryo 16-18hr  (1219) embryo 18-20hr  (1152) embryo 20-22hr  (1202) embryo 22-24hr  (1084) larva L1  (1224) larva L2  (847) larva L3 12hr old  (715) larva L3 puffstage 1-2  (666) larva L3 puffstage 3-6  (792) larva L3 puffstage 7-9  (967) white prepupae new  (966) white prepupae 12hr  (1094) white prepupae 24hr  (944) pupae 2d postWPP  (807) pupae 3d postWPP  (592) pupae 4d postWPP  (792) adult male 01day  (581) adult male 05day  (631) adult male 30day  (671) adult female 01day  (989) adult female 05day  (795) adult female 30day  (836) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    885 embryo 02-04hr    1492 embryo 04-06hr    1659 embryo 06-08hr    1670 embryo 08-10hr    1760 embryo 10-12hr    1904 embryo 12-14hr    1129 embryo 14-16hr    1383 embryo 16-18hr    1219 embryo 18-20hr    1152 embryo 20-22hr    1202 embryo 22-24hr    1084 larva L1    1224 larva L2    847 larva L3 12hr old    715 larva L3 puffstage 1-2    666 larva L3 puffstage 3-6    792 larva L3 puffstage 7-9    967 white prepupae new    966 white prepupae 12hr    1094 white prepupae 24hr    944 pupae 2d postWPP    807 pupae 3d postWPP    592 pupae 4d postWPP    792 adult male 01day    581 adult male 05day    631 adult male 30day    671 adult female 01day    989 adult female 05day    795 adult female 30day    836 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    898 Schneider line 2 Sg4    1392 embryonic 1182-4H    784 embryonic GM2    863 embryonic Kc167    1566 embryonic S1    1129 embryonic S3    556 leg disc CME L1    1032 wing disc CME-W2    1306 wing disc ML-DmD8    1196 wing disc ML-DmD9    789 wing disc ML-DmD16-c3    527 wing disc ML-DmD21    1538 wing disc ML-DmD32    1213 haltere disc ML-DmD17-c3    992 eye-antennal disc ML-DmD11    1311 antennal disc ML-DmD20-c5    1332 mixed discs ML-DmD4-c1    1214 CNS ML-DmBG1-c1    1027 CNS ML-DmBG2-c2    1274 tumorous blood cells mbn2    1014 ovary fGS/OSS    627 ovary OSC    861 ovary OSS    234 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (898) Schneider line 2 Sg4  (1392) embryonic 1182-4H  (784) embryonic GM2  (863) embryonic Kc167  (1566) embryonic S1  (1129) embryonic S3  (556) leg disc CME L1  (1032) wing disc CME-W2  (1306) wing disc ML-DmD8  (1196) wing disc ML-DmD9  (789) wing disc ML-DmD16-c3  (527) wing disc ML-DmD21  (1538) wing disc ML-DmD32  (1213) haltere disc ML-DmD17-c3  (992) eye-antennal disc ML-DmD11  (1311) antennal disc ML-DmD20-c5  (1332) mixed discs ML-DmD4-c1  (1214) CNS ML-DmBG1-c1  (1027) CNS ML-DmBG2-c2  (1274) tumorous blood cells mbn2  (1014) ovary fGS/OSS  (627) ovary OSC  (861) ovary OSS  (234) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (898) Schneider line 2 Sg4  (1392) embryonic 1182-4H  (784) embryonic GM2  (863) embryonic Kc167  (1566) embryonic S1  (1129) embryonic S3  (556) leg disc CME L1  (1032) wing disc CME-W2  (1306) wing disc ML-DmD8  (1196) wing disc ML-DmD9  (789) wing disc ML-DmD16-c3  (527) wing disc ML-DmD21  (1538) wing disc ML-DmD32  (1213) haltere disc ML-DmD17-c3  (992) eye-antennal disc ML-DmD11  (1311) antennal disc ML-DmD20-c5  (1332) mixed discs ML-DmD4-c1  (1214) CNS ML-DmBG1-c1  (1027) CNS ML-DmBG2-c2  (1274) tumorous blood cells mbn2  (1014) ovary fGS/OSS  (627) ovary OSC  (861) ovary OSS  (234) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    898 Schneider line 2 Sg4    1392 embryonic 1182-4H    784 embryonic GM2    863 embryonic Kc167    1566 embryonic S1    1129 embryonic S3    556 leg disc CME L1    1032 wing disc CME-W2    1306 wing disc ML-DmD8    1196 wing disc ML-DmD9    789 wing disc ML-DmD16-c3    527 wing disc ML-DmD21    1538 wing disc ML-DmD32    1213 haltere disc ML-DmD17-c3    992 eye-antennal disc ML-DmD11    1311 antennal disc ML-DmD20-c5    1332 mixed discs ML-DmD4-c1    1214 CNS ML-DmBG1-c1    1027 CNS ML-DmBG2-c2    1274 tumorous blood cells mbn2    1014 ovary fGS/OSS    627 ovary OSC    861 ovary OSS    234 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    898 Schneider line 2 Sg4    1392 embryonic 1182-4H    784 embryonic GM2    863 embryonic Kc167    1566 embryonic S1    1129 embryonic S3    556 leg disc CME L1    1032 wing disc CME-W2    1306 wing disc ML-DmD8    1196 wing disc ML-DmD9    789 wing disc ML-DmD16-c3    527 wing disc ML-DmD21    1538 wing disc ML-DmD32    1213 haltere disc ML-DmD17-c3    992 eye-antennal disc ML-DmD11    1311 antennal disc ML-DmD20-c5    1332 mixed discs ML-DmD4-c1    1214 CNS ML-DmBG1-c1    1027 CNS ML-DmBG2-c2    1274 tumorous blood cells mbn2    1014 ovary fGS/OSS    627 ovary OSC    861 ovary OSS    234 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (898) Schneider line 2 Sg4  (1392) embryonic 1182-4H  (784) embryonic GM2  (863) embryonic Kc167  (1566) embryonic S1  (1129) embryonic S3  (556) leg disc CME L1  (1032) wing disc CME-W2  (1306) wing disc ML-DmD8  (1196) wing disc ML-DmD9  (789) wing disc ML-DmD16-c3  (527) wing disc ML-DmD21  (1538) wing disc ML-DmD32  (1213) haltere disc ML-DmD17-c3  (992) eye-antennal disc ML-DmD11  (1311) antennal disc ML-DmD20-c5  (1332) mixed discs ML-DmD4-c1  (1214) CNS ML-DmBG1-c1  (1027) CNS ML-DmBG2-c2  (1274) tumorous blood cells mbn2  (1014) ovary fGS/OSS  (627) ovary OSC  (861) ovary OSS  (234) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (898) Schneider line 2 Sg4  (1392) embryonic 1182-4H  (784) embryonic GM2  (863) embryonic Kc167  (1566) embryonic S1  (1129) embryonic S3  (556) leg disc CME L1  (1032) wing disc CME-W2  (1306) wing disc ML-DmD8  (1196) wing disc ML-DmD9  (789) wing disc ML-DmD16-c3  (527) wing disc ML-DmD21  (1538) wing disc ML-DmD32  (1213) haltere disc ML-DmD17-c3  (992) eye-antennal disc ML-DmD11  (1311) antennal disc ML-DmD20-c5  (1332) mixed discs ML-DmD4-c1  (1214) CNS ML-DmBG1-c1  (1027) CNS ML-DmBG2-c2  (1274) tumorous blood cells mbn2  (1014) ovary fGS/OSS  (627) ovary OSC  (861) ovary OSS  (234) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    898 Schneider line 2 Sg4    1392 embryonic 1182-4H    784 embryonic GM2    863 embryonic Kc167    1566 embryonic S1    1129 embryonic S3    556 leg disc CME L1    1032 wing disc CME-W2    1306 wing disc ML-DmD8    1196 wing disc ML-DmD9    789 wing disc ML-DmD16-c3    527 wing disc ML-DmD21    1538 wing disc ML-DmD32    1213 haltere disc ML-DmD17-c3    992 eye-antennal disc ML-DmD11    1311 antennal disc ML-DmD20-c5    1332 mixed discs ML-DmD4-c1    1214 CNS ML-DmBG1-c1    1027 CNS ML-DmBG2-c2    1274 tumorous blood cells mbn2    1014 ovary fGS/OSS    627 ovary OSC    861 ovary OSS    234 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    278 cold shock, 4-day adult    210 heat shock, 4-day adult    507 Cadmium 50 mM 6 hrs, larvae L3    402 Cadmium 50 mM 12 hrs, larvae L3    457 Cadmium 50 mM 48 hrs, 4-day adult    542 Cadmium 100 mM 48 hrs, 4-day adult    661 Copper 0.5 mM 12 hrs, larvae L3    365 Copper 15 mM 48 hrs, 4-day adult    863 Zinc 5 mM 12 hrs, larvae L3    286 Zinc 4.5 mM 48 hrs, 4-day adult    645 Ethanol 2.5% 3 hrs, larvae L3    476 Ethanol 5% 3 hrs, larvae L3    502 Ethanol 10% 3 hrs, larvae L3    361 Caffeine 1.5 mg/ml 4 hrs, larvae L3    484 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    790 Caffeine 25 mg/ml 48 hrs, 4-day adult    324 Paraquat 5 mM 48 hrs, 4-day adult    669 Paraquat 10 mM 48 hrs, 4-day adult    507 Rotenone 2 μg 12 hrs, larvae L3    498 Rotenone 8 μg 12 hrs, larvae L3    490 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (278) cold shock, 4-day adult  (210) heat shock, 4-day adult  (507) Cadmium 50 mM 6 hrs, larvae L3  (402) Cadmium 50 mM 12 hrs, larvae L3  (457) Cadmium 50 mM 48 hrs, 4-day adult  (542) Cadmium 100 mM 48 hrs, 4-day adult  (661) Copper 0.5 mM 12 hrs, larvae L3  (365) Copper 15 mM 48 hrs, 4-day adult  (863) Zinc 5 mM 12 hrs, larvae L3  (286) Zinc 4.5 mM 48 hrs, 4-day adult  (645) Ethanol 2.5% 3 hrs, larvae L3  (476) Ethanol 5% 3 hrs, larvae L3  (502) Ethanol 10% 3 hrs, larvae L3  (361) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (484) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (790) Caffeine 25 mg/ml 48 hrs, 4-day adult  (324) Paraquat 5 mM 48 hrs, 4-day adult  (669) Paraquat 10 mM 48 hrs, 4-day adult  (507) Rotenone 2 μg 12 hrs, larvae L3  (498) Rotenone 8 μg 12 hrs, larvae L3  (490) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (278) cold shock, 4-day adult  (210) heat shock, 4-day adult  (507) Cadmium 50 mM 6 hrs, larvae L3  (402) Cadmium 50 mM 12 hrs, larvae L3  (457) Cadmium 50 mM 48 hrs, 4-day adult  (542) Cadmium 100 mM 48 hrs, 4-day adult  (661) Copper 0.5 mM 12 hrs, larvae L3  (365) Copper 15 mM 48 hrs, 4-day adult  (863) Zinc 5 mM 12 hrs, larvae L3  (286) Zinc 4.5 mM 48 hrs, 4-day adult  (645) Ethanol 2.5% 3 hrs, larvae L3  (476) Ethanol 5% 3 hrs, larvae L3  (502) Ethanol 10% 3 hrs, larvae L3  (361) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (484) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (790) Caffeine 25 mg/ml 48 hrs, 4-day adult  (324) Paraquat 5 mM 48 hrs, 4-day adult  (669) Paraquat 10 mM 48 hrs, 4-day adult  (507) Rotenone 2 μg 12 hrs, larvae L3  (498) Rotenone 8 μg 12 hrs, larvae L3  (490) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    278 cold shock, 4-day adult    210 heat shock, 4-day adult    507 Cadmium 50 mM 6 hrs, larvae L3    402 Cadmium 50 mM 12 hrs, larvae L3    457 Cadmium 50 mM 48 hrs, 4-day adult    542 Cadmium 100 mM 48 hrs, 4-day adult    661 Copper 0.5 mM 12 hrs, larvae L3    365 Copper 15 mM 48 hrs, 4-day adult    863 Zinc 5 mM 12 hrs, larvae L3    286 Zinc 4.5 mM 48 hrs, 4-day adult    645 Ethanol 2.5% 3 hrs, larvae L3    476 Ethanol 5% 3 hrs, larvae L3    502 Ethanol 10% 3 hrs, larvae L3    361 Caffeine 1.5 mg/ml 4 hrs, larvae L3    484 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    790 Caffeine 25 mg/ml 48 hrs, 4-day adult    324 Paraquat 5 mM 48 hrs, 4-day adult    669 Paraquat 10 mM 48 hrs, 4-day adult    507 Rotenone 2 μg 12 hrs, larvae L3    498 Rotenone 8 μg 12 hrs, larvae L3    490 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    278 cold shock, 4-day adult    210 heat shock, 4-day adult    507 Cadmium 50 mM 6 hrs, larvae L3    402 Cadmium 50 mM 12 hrs, larvae L3    457 Cadmium 50 mM 48 hrs, 4-day adult    542 Cadmium 100 mM 48 hrs, 4-day adult    661 Copper 0.5 mM 12 hrs, larvae L3    365 Copper 15 mM 48 hrs, 4-day adult    863 Zinc 5 mM 12 hrs, larvae L3    286 Zinc 4.5 mM 48 hrs, 4-day adult    645 Ethanol 2.5% 3 hrs, larvae L3    476 Ethanol 5% 3 hrs, larvae L3    502 Ethanol 10% 3 hrs, larvae L3    361 Caffeine 1.5 mg/ml 4 hrs, larvae L3    484 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    790 Caffeine 25 mg/ml 48 hrs, 4-day adult    324 Paraquat 5 mM 48 hrs, 4-day adult    669 Paraquat 10 mM 48 hrs, 4-day adult    507 Rotenone 2 μg 12 hrs, larvae L3    498 Rotenone 8 μg 12 hrs, larvae L3    490 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (278) cold shock, 4-day adult  (210) heat shock, 4-day adult  (507) Cadmium 50 mM 6 hrs, larvae L3  (402) Cadmium 50 mM 12 hrs, larvae L3  (457) Cadmium 50 mM 48 hrs, 4-day adult  (542) Cadmium 100 mM 48 hrs, 4-day adult  (661) Copper 0.5 mM 12 hrs, larvae L3  (365) Copper 15 mM 48 hrs, 4-day adult  (863) Zinc 5 mM 12 hrs, larvae L3  (286) Zinc 4.5 mM 48 hrs, 4-day adult  (645) Ethanol 2.5% 3 hrs, larvae L3  (476) Ethanol 5% 3 hrs, larvae L3  (502) Ethanol 10% 3 hrs, larvae L3  (361) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (484) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (790) Caffeine 25 mg/ml 48 hrs, 4-day adult  (324) Paraquat 5 mM 48 hrs, 4-day adult  (669) Paraquat 10 mM 48 hrs, 4-day adult  (507) Rotenone 2 μg 12 hrs, larvae L3  (498) Rotenone 8 μg 12 hrs, larvae L3  (490) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (278) cold shock, 4-day adult  (210) heat shock, 4-day adult  (507) Cadmium 50 mM 6 hrs, larvae L3  (402) Cadmium 50 mM 12 hrs, larvae L3  (457) Cadmium 50 mM 48 hrs, 4-day adult  (542) Cadmium 100 mM 48 hrs, 4-day adult  (661) Copper 0.5 mM 12 hrs, larvae L3  (365) Copper 15 mM 48 hrs, 4-day adult  (863) Zinc 5 mM 12 hrs, larvae L3  (286) Zinc 4.5 mM 48 hrs, 4-day adult  (645) Ethanol 2.5% 3 hrs, larvae L3  (476) Ethanol 5% 3 hrs, larvae L3  (502) Ethanol 10% 3 hrs, larvae L3  (361) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (484) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (790) Caffeine 25 mg/ml 48 hrs, 4-day adult  (324) Paraquat 5 mM 48 hrs, 4-day adult  (669) Paraquat 10 mM 48 hrs, 4-day adult  (507) Rotenone 2 μg 12 hrs, larvae L3  (498) Rotenone 8 μg 12 hrs, larvae L3  (490) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    278 cold shock, 4-day adult    210 heat shock, 4-day adult    507 Cadmium 50 mM 6 hrs, larvae L3    402 Cadmium 50 mM 12 hrs, larvae L3    457 Cadmium 50 mM 48 hrs, 4-day adult    542 Cadmium 100 mM 48 hrs, 4-day adult    661 Copper 0.5 mM 12 hrs, larvae L3    365 Copper 15 mM 48 hrs, 4-day adult    863 Zinc 5 mM 12 hrs, larvae L3    286 Zinc 4.5 mM 48 hrs, 4-day adult    645 Ethanol 2.5% 3 hrs, larvae L3    476 Ethanol 5% 3 hrs, larvae L3    502 Ethanol 10% 3 hrs, larvae L3    361 Caffeine 1.5 mg/ml 4 hrs, larvae L3    484 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    790 Caffeine 25 mg/ml 48 hrs, 4-day adult    324 Paraquat 5 mM 48 hrs, 4-day adult    669 Paraquat 10 mM 48 hrs, 4-day adult    507 Rotenone 2 μg 12 hrs, larvae L3    498 Rotenone 8 μg 12 hrs, larvae L3    490 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_31 mE1_20_mRNA_expression_cluster_01
External Data & Images
Linkouts	BDGP expression data • GM14109 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001942 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9075-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal eIF-4aCB03721 lethal, with Scer\GAL4pnr-MD237 eIF-4aGD14111 lethal (with Df(2L)GpdhA) eIF-4aYE9 lethal | embryonic stage (with Df(2L)E110) eIF-4aYE9 lethal | embryonic stage | recessive eIF-4aYE9 lethal | first instar larval stage (with Df(2L)E110) eIF-4aYE9 lethal | first instar larval stage (with eIF-4a02439) eIF-4aYE9 lethal | first instar larval stage (with eIF-4aYE9) eIF-4a02439 lethal | larval stage | recessive eIF-4a162-3 eIF-4a1006 eIF-4a1013 eIF-4a1069 eIF-4a02439 eIF-4ak14518 eIF-4ak14610 eIF-4ak15403 lethal | pupal stage, with Scer\GAL4pnr-MD237 eIF-4aGD14111 lethal | recessive eIF-4a1-9 eIF-4a26Ac-1 eIF-4a26Ac-2 eIF-4a26Ac-3 eIF-4a162-3 eIF-4a162-5 eIF-4a162-7 eIF-4a162-8 eIF-4a162-18 eIF-4a162-R36 eIF-4a162-R39 eIF-4a162-R59 eIF-4a02439 eIF-4a02623 eIF-4a06689 eIF-4aDS-16 eIF-4ak01501 eIF-4ak01801 eIF-4ak05206 eIF-4ak07120 eIF-4ak07519 eIF-4ak08101 eIF-4ak08109 eIF-4ak08120 eIF-4ak09234 eIF-4ak09319a eIF-4aPN-1 eIF-4aPN-8 lethal | second instar larval stage (with Df(2L)E110) eIF-4a02439 lethal | second instar larval stage (with eIF-4a02439) eIF-4aYE9 lethal | second instar larval stage (with eIF-4aYE9) eIF-4a02439 lethal | third instar larval stage (with Df(2L)E110) eIF-4a02439 partially lethal - majority die | recessive eIF-4a162-R1 eIF-4a162-R30 eIF-4a162-R35 eIF-4a162-R75 Other Phenotypes Allele decreased cell number | germline clone eIF-4a1006 developmental rate defective | dominant | larval stage eIF-4aYE9 mitotic cell cycle defective | recessive eIF-4a1006 eIF-4a1013 eIF-4a1069 eIF-4ak14518 eIF-4ak14610 eIF-4ak15403 neuroanatomy defective, with Scer\GAL4elav-C155 eIF-4aEP1011 Phenotype manifest in Allele amnioserosa eIF-4a1006 eIF-4aYE9 amnioserosa (with Df(2L)GpdhA) eIF-4a1006 anterior fascicle & synapse, with Scer\GAL4elav-C155 eIF-4aEP1011 cephalopharyngeal skeleton eIF-4aYE9 cuticle eIF-4a162-18 eIF-4a162-5 eIF-4a162-7 eIF-4a162-8 embryonic/first instar larval cuticle eIF-4aYE9 eye eIF-4a1006 eIF-4a1013 female germline stem cell | germline clone eIF-4a1006 eIF-4a1013 eIF-4ak01501 head eIF-4a162-18 eIF-4a162-5 eIF-4a162-7 eIF-4a162-8 intersegmental nerve, with Scer\GAL4elav-C155 eIF-4aEP1011 parasegment 1 eIF-4a162-18 eIF-4a162-5 eIF-4a162-7 eIF-4a162-8 parasegment 2 eIF-4a162-18 eIF-4a162-5 eIF-4a162-7 eIF-4a162-8 parasegment 3 eIF-4a162-18 eIF-4a162-5 eIF-4a162-7 eIF-4a162-8 parasegment 4 eIF-4a162-18 eIF-4a162-5 eIF-4a162-7 eIF-4a162-8 parasegment 5 eIF-4a162-18 eIF-4a162-5 eIF-4a162-7 eIF-4a162-8 parasegment 6 eIF-4a162-18 eIF-4a162-5 eIF-4a162-7 eIF-4a162-8 parasegment 7 eIF-4a162-18 eIF-4a162-5 eIF-4a162-7 eIF-4a162-8 parasegment 8 eIF-4a162-18 eIF-4a162-5 eIF-4a162-7 eIF-4a162-8 parasegment 9 eIF-4a162-18 eIF-4a162-5 eIF-4a162-7 eIF-4a162-8 parasegment 10 eIF-4a162-18 eIF-4a162-5 eIF-4a162-7 eIF-4a162-8 parasegment 11 eIF-4a162-18 eIF-4a162-5 eIF-4a162-7 eIF-4a162-8 parasegment 12 eIF-4a162-18 eIF-4a162-5 eIF-4a162-7 eIF-4a162-8 parasegment 13 eIF-4a162-18 eIF-4a162-5 eIF-4a162-7 eIF-4a162-8 parasegment 14 eIF-4a162-18 eIF-4a162-5 eIF-4a162-7 eIF-4a162-8 parasegment 15 eIF-4a162-18 eIF-4a162-5 eIF-4a162-7 eIF-4a162-8 wing disc eIF-4a1006 eIF-4a1013 eIF-4a1069 eIF-4a162-3
Classical Alleles ( 61 )
For All Classical Alleles Show
Allele of eIF-4a Class Mutagen Stocks Known lesion eIF-4ak01501 P-element activity 2 Yes eIF-4aNP1272 2 -- eIF-4a02439 P-element activity 1 -- eIF-4a1013 P-element activity 1 Yes eIF-4a5-HA-1998 1 -- eIF-4aCB-0582-3 1 -- eIF-4aCB-0707-3 1 -- eIF-4ad06487 P-element activity 1 -- eIF-4ak01801 P-element activity 1 -- eIF-4ak07120 P-element activity 1 -- eIF-4ak14518 P-element activity 1 -- eIF-4aNP6380 1 -- eIF-4aUM-8048-3 1 -- eIF-4a02623 P-element activity 0 -- eIF-4a06689 P-element activity 0 -- eIF-4a09A09 0 Yes eIF-4a1-9 ethyl methanesulfonate 0 -- eIF-4a1006 P-element activity 0 Yes eIF-4a1069 P-element activity 0 Yes eIF-4a10A07 0 Yes eIF-4a10A12 0 Yes eIF-4a162-18 X ray 0 Yes eIF-4a162-3 P-element activity 0 Yes eIF-4a162-5 X ray 0 Yes eIF-4a162-7 X ray 0 Yes eIF-4a162-8 X ray 0 Yes eIF-4a162-R1 Delta2-3 0 Yes eIF-4a162-R30 Delta2-3 0 Yes eIF-4a162-R35 Delta2-3 0 Yes eIF-4a162-R36 Delta2-3 0 Yes eIF-4a162-R39 Delta2-3 0 Yes eIF-4a162-R59 Delta2-3 0 Yes eIF-4a162-R75 Delta2-3 0 Yes eIF-4a24A03 0 Yes eIF-4a26Ac-1 ethyl methanesulfonate 0 -- eIF-4a26Ac-2 ethyl methanesulfonate 0 -- eIF-4a26Ac-3 ethyl methanesulfonate 0 -- eIF-4aCB03721 P-element activity 0 Yes eIF-4aDS-16 ethyl methanesulfonate 0 -- eIF-4aEP1011 P-element activity 0 Yes eIF-4aEP2078 P-element activity 0 -- eIF-4aEP2166 P-element activity 0 -- eIF-4aG29 P-element activity 0 -- eIF-4aGS-A2207 Delta2-3 0 -- eIF-4ak05206 P-element activity 0 -- eIF-4ak07218 0 -- eIF-4ak07519 P-element activity 0 -- eIF-4ak08101 P-element activity 0 -- eIF-4ak08109 P-element activity 0 -- eIF-4ak08120 P-element activity 0 -- eIF-4ak09234 P-element activity 0 -- eIF-4ak09319a P-element activity 0 -- eIF-4ak09406 P-element activity 0 -- eIF-4ak14610 P-element activity 0 -- eIF-4ak15403 0 -- eIF-4ak16006 0 -- eIF-4ak16010 0 -- eIF-4aPN-1 ethyl methanesulfonate 0 -- eIF-4aPN-8 ethyl methanesulfonate 0 -- eIF-4aunspecified 0 -- eIF-4aYE9 antimorphic allele - genetic evidence ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of eIF-4a Class Mutagen Stocks Known lesion eIF-4aGD14111 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes eIF-4aHMS00927 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes eIF-4aKK107917 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes eIF-4aR321H.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes eIF-4aScer\UAS.cLa in vitro construct - regulatory fusion 0 Yes eIF-4aScer\UAS.P\T.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)BSC184 (Christensen and Cook, 2006.8.29) Df(2L)chic-106 (Verheyen and Cooley, 1994) Df(2L)chic-112 (Verheyen and Cooley, 1994) Df(2L)chic-129 (Verheyen and Cooley, 1994) Df(2L)chic38 (Verheyen and Cooley, 1994) Df(2L)chic103 (Verheyen and Cooley, 1994) Df(2L)chic139 (Verheyen and Cooley, 1994) Df(2L)cl-h3 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2L)E110 (Spradling et al., 1999, Li et al., 2005, BDGP Project Members, 1994-1999) Df(2L)Exel8017 (Ryder, 2004.4.26) Df(2L)GpdhA (Spradling et al., 1999, Li et al., 2005, Kotarski et al., 1983, Dorn et al., 1993, BDGP Project Members, 1994-1999, Beaton, 1997.3.4) Ts(YLt;2Lt)H69+Ts(YLt;2Rt)D211 (Kotarski et al., 1983)
Not disrupted in	Df(2L)2802 (Kotarski et al., 1983) Df(2L)ade2-3 (BDGP Project Members, 1994-1999) Df(2L)cl1 (Kotarski et al., 1983) Df(2L)cl2 (Kotarski et al., 1983) Df(2L)cl7 (Kotarski et al., 1983, Dorn et al., 1993) Df(2L)Gpdh75 (Kotarski et al., 1983) Df(2L)Gpdh78 (Kotarski et al., 1983) Df(2L)TW161 (BDGP Project Members, 1994-1999) Df(2R)M60E (BDGP Project Members, 1994-1999) Df(2R)Np3 (BDGP Project Members, 1994-1999) Df(2R)Np5 (BDGP Project Members, 1994-1999) Df(2R)Pu-D17 (BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD14111} NA P{KK107917} NA P{TRiP.HMS00927} NA P{UAS-eIF-4a.L} NA P{UAS-eIF-4a.MYC} NA P{UAS-eIF-4a.R321H} NA reporter construct P{eIF-4a-lacZ.-436mutDREall} No P{eIF-4a-lacZ.-436wt} No
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}eIF-4a1006 No P{lacW}eIF-4a1013 No P{lacW}eIF-4a1069 No P{lacW}eIF-4ak01501 No P{lacW}eIF-4ak01801 No P{lacW}eIF-4ak05206 No P{lacW}eIF-4ak07120 No P{lacW}eIF-4ak07519 No P{lacW}eIF-4ak08101 No P{lacW}eIF-4ak08109 No P{lacW}eIF-4ak08120 No P{lacW}eIF-4ak09234 No P{lacW}eIF-4ak09319a No P{lacW}eIF-4ak09406 No P{lacW}eIF-4ak14518 No P{lacW}eIF-4ak14610 No P{lacW}l(2)SH2226SH2226 No P{PZ}eIF-4a02439 No P{PZ}eIF-4a02623 No P{PZ}eIF-4a06689 No insertion of mobile activating element P{EP}eIF-4aEP1011 NA P{EP}eIF-4aEP2078 NA P{EP}eIF-4aEP2166 NA P{GSV1}C174C174 NA P{GSV1}eIF-4aGS-A2207 NA P{XP}eIF-4ad06487 NA miscellaneous insertions P{?hsneo.ry+}eIF-4a162-R1 NA P{?hsneo.ry+}eIF-4a162-R30 NA P{?hsneo.ry+}eIF-4a162-R35 NA P{?hsneo.ry+}eIF-4a162-R36 NA P{?hsneo.ry+}eIF-4a162-R39 NA P{?hsneo.ry+}eIF-4a162-R59 NA P{?hsneo.ry+}eIF-4a162-R75 NA P{hsneo.ry+}eIF-4a162-3 NA P{PTT-GB}eIF-4aCB03721 NA P{PTT-un1}eIF-4aG29 NA P{RS3}eIF-4aCB-0582-3 NA P{RS3}eIF-4aCB-0707-3 NA P{RS3}eIF-4aUM-8048-3 NA P{RS5}eIF-4a5-HA-1998 NA P{wHy}eIF-4a09A09 NA P{wHy}eIF-4a10A07 NA P{wHy}eIF-4a10A12 NA P{wHy}eIF-4a24A03 NA insertion of enhancer trap binary system P{GawB}eIF-4aNP1272 No P{GawB}eIF-4aNP6380 No
Gene Ontology: Function, Process & Cellular Component ( 27 unique terms )
Terms Based on Experimental Evidence ( 13 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
centrosome organization inferred from mutant phenotype (Müller et al., 2010) dorsal/ventral axis specification inferred from mutant phenotype (Li and Gelbart, 2002) female germ-line stem cell division inferred from genetic interaction with bam (Shen et al., 2009) inferred from mutant phenotype (Shen et al., 2009) germ-line stem cell maintenance inferred from mutant phenotype (Shen et al., 2009) mitosis inferred from mutant phenotype (Ducat et al., 2008) mitotic spindle elongation inferred from mutant phenotype (Goshima et al., 2007) mitotic spindle organization inferred from mutant phenotype (Goshima et al., 2007) oogenesis inferred from genetic interaction with bam (Shen et al., 2009) regulation of alternative mRNA splicing, via spliceosome inferred from mutant phenotype (Park et al., 2004, Katzenberger et al., 2009) response to DNA damage stimulus inferred from mutant phenotype (Ravi et al., 2009)
Cellular Component
CV term Evidence References
centrosome inferred from direct assay (Müller et al., 2010) microtubule associated complex inferred from direct assay (Hughes et al., 2008) mitotic spindle inferred from direct assay (Müller et al., 2010)
Terms Based on Predictions or Assertions ( 14 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000629, InterPro:IPR001650, InterPro:IPR011545 (FlyBase Curators et al., 2004-) ATP-dependent helicase activity inferred from electronic annotation with InterPro:IPR000629, InterPro:IPR011545 (FlyBase Curators et al., 2004-) mRNA binding non-traceable author statement (Swiss-Prot Project Members, 1993.7.1) RNA cap binding non-traceable author statement (Swiss-Prot Project Members, 1993.7.1) RNA helicase activity inferred from sequence or structural similarity (Dorn et al., 1993) inferred from sequence or structural similarity with Saccharomyces TIF2 (Lasko, 2000) single-stranded DNA-dependent ATP-dependent DNA helicase activity non-traceable author statement (Swiss-Prot Project Members, 1993.7.1) translation initiation factor activity inferred from sequence or structural similarity (Lasko, 2000) inferred from sequence or structural similarity with Saccharomyces TIF1 (FlyBase, 1992-) non-traceable author statement (Dorn, 1992.10.29, Swiss-Prot Project Members, 1993.7.1)
Biological Process
CV term Evidence References
DNA unwinding involved in replication non-traceable author statement (Swiss-Prot Project Members, 1993.7.1) imaginal disc growth traceable author statement (Weinkove and Leevers, 2000) instar larval development traceable author statement (Weinkove and Leevers, 2000) translational initiation inferred from sequence or structural similarity (Lasko, 2000) inferred from sequence or structural similarity with Saccharomyces TIF1 (FlyBase, 1992-) non-traceable author statement (Dorn, 1992.10.29, Swiss-Prot Project Members, 1993.7.1)
Cellular Component
CV term Evidence References
cytosol inferred from sequence or structural similarity (Lasko, 2000) non-traceable author statement (Dorn, 1992.10.29) eukaryotic translation initiation factor 4F complex inferred from sequence or structural similarity (Lasko, 2000) inferred from sequence or structural similarity with Saccharomyces TIF1 (FlyBase, 1992-) nucleus inferred by curator from GO:0000381 (Park et al., 2004)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions eIF-4a allele Gene References eIF-4a162-3 Dp (Galloni and Edgar, 1999) E2f (Galloni and Edgar, 1999) N (Rottgen et al., 1998) eIF-4a1006 Dp (Galloni and Edgar, 1999) E2f (Galloni and Edgar, 1999) Pten (Gao et al., 2000) eIF-4a1013 Dp (Galloni and Edgar, 1999) E2f (Galloni and Edgar, 1999) eIF-4a1069 Dp (Galloni and Edgar, 1999) E2f (Galloni and Edgar, 1999) Pten (Gao et al., 2000) eIF-4a02439 peb (Wilk et al., 2004) eIF-4ak14518 peb (Wilk et al., 2004) unspecified ct (Krupp et al., 2005) dpp (Li and Gelbart, 2002, Li et al., 2005) l(1)sc (Rottgen et al., 1998)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60000 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0001942 DroID - A comprehensive database of gene and protein interactions. • FBgn0001942 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 33835
Orthologs
OrthoDB Orthologs (54) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG622B4N Dipteran inclusive ortholog search EOG6Z0BF7 Insect inclusive ortholog search EOG65MM1T Arthropod inclusive ortholog search EOG6F1VJM Metazoa inclusive ortholog search EOG63NM66
Orthologs in Drosophila Species (EOG622B4N)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\eIF-4a     Drosophila simulans   Dsim\GD23375 Y   Drosophila sechellia   Dsec\GM18587 Y   Drosophila erecta   Dere\GG25110 Y   Drosophila yakuba   Dyak\eIF-4a Y   Drosophila ananassae   Dana\GF15595 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA21521 Y   Drosophila persimilis   Dper\GL19047 Y   Drosophila willistoni   Dwil\GK14711 Y   Drosophila virilis   Dvir\GJ15436 Y   Drosophila mojavensis   Dmoj\GI17537 Y   Drosophila grimshawi   Dgri\GH11018 Y
Orthologs in non-Drosophila Dipterans (EOG6Z0BF7)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL013359   Anopheles gambiae Malaria mosquito  Agam\AGAP009863   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ801619
Orthologs in non-Dipteran Insects (EOG65MM1T)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB51710   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG018524   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH21451   Atta cephalotes Leafcutter ant  Acep\ACEP16210   Camponotus floridanus Florida carpenter ant  Cflo\CFLO20522   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15616   Linepithema humile Argentine ant  Lhum\LH24849   Pogonomyrmex barbatus Red harvester ant  Pbar\PB15901   Solenopsis invicta Red fire ant  Sinv\SINV25515   Acyrthosiphon pisum Pea aphid  Apim\ACYPI002483   Bombyx mori Silkmoth  Bmor\BGIBMGA003186   Pediculus humanus Human body louse  Phum\PHUM148640   Tribolium castaneum Red flour beetle  Tcas\TC014113
Orthologs in non-Insect Arthropods (EOG6F1VJM)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\hmg2   Ixodes scapularis Deer tick  Isca\ISCW015864
Orthologs in non-Arthropod Metazoa (EOG63NM66)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\Y65B4A.6 Y Caenorhabditis elegans Nematode  Cele\F57B9.3 Y Caenorhabditis elegans Nematode  Cele\inf-1 Y Caenorhabditis elegans Nematode  Cele\F33D11.10 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_014808gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_023083gn Y Danio rerio Zebrafish  Drer\eif4a2 Y Danio rerio Zebrafish  Drer\eif4a1a Y Danio rerio Zebrafish  Drer\eif4a1b Y Danio rerio Zebrafish  Drer\eif4a3 Y Xenopus tropicalis Western clawed frog  Xtro\eif4a2 Y Xenopus tropicalis Western clawed frog  Xtro\eif4a1 Y Xenopus tropicalis Western clawed frog  Xtro\eif4a3 Y Gallus gallus Domestic chicken  Ggal\EIF4A2 Y Gallus gallus Domestic chicken  Ggal\EIF4A3 Y Mus musculus House mouse  Mmus\Eif4a1 Y Mus musculus House mouse  Mmus\Gm5576 Y Mus musculus House mouse  Mmus\Eif4a3 Y Mus musculus House mouse  Mmus\Gm8994 Y Rattus norvegicus Norway rat  Rnor\Eif4a2 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000027316 Y Rattus norvegicus Norway rat  Rnor\Eif4a1 Y Homo sapiens Human  Hsap\EIF4A1 Y Homo sapiens Human  Hsap\EIF4A3 Y
Human Orthologs (2)
Gene OMIM HGNC Hsap\EIF4A1     Hsap\EIF4A3
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD23375 Drosophila sechellia Dsec\GM18587 Drosophila erecta Dere\GG25110 Drosophila yakuba Dyak\eIF-4a Drosophila ananassae Dana\GF15595 Drosophila pseudoobscura pseudoobscura Dpse\GA21521 Drosophila persimilis Dper\GL19047 Drosophila willistoni Dwil\GK14711 Drosophila virilis Dvir\GJ15436 Drosophila mojavensis Dmoj\GI17537 Drosophila grimshawi Dgri\GH11018
Stocks & Reagents
Stocks Listed in FlyBase ( 19 )
Bloomington	8647 w*; P{lacW}eIF-4a1013/CyO 11190 P{PZ}eIF-4a02439 cn1/CyO; ry506 33970 y1 sc* v1; P{TRiP.HMS00927}attP2 10506 y1 w67c23; P{lacW}eIF-4ak01501/CyO
Harvard	- P{XP}eIF-4ad06487
Kyoto	123245 w1118; P{RS3}eIF-4aCB-0582-3 123292 w1118; P{RS3}eIF-4aCB-0707-3 124307 w1118; P{RS3}eIF-4aUM-8048-3 125515 w1118; P{RS5}eIF-4a5-HA-1998
VDRC	v100310 P{KK107917}VIE-260B v42202 w1118; P{GD14111}v42202 v42201 w1118; P{GD14111}v42201/CyO
	More stocks available...
Genomic Clones ( 2 )
	BACR10M11 BACR48E14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 910 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT04852 GH03937 GH17619 GM14109 RE22480
Other clones	LD22268 yak-em_eIF
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT02170 AT03112 AT04436 AT08483 AT09694 AT13057 AT13234 AT14958 AT23385 AT28812 AT29165 GH03487 GH03971 GH04406 GH10237 GH12628 GH13143 GH17568 GH17902 GH17993 GH19458 GH20855 GH22211 GH23403 GH25019 GH28093 GM02255 GM02949 GM03589 GM04868 GM05852 GM06410 GM07523 GM07620 GM09465 GM09633 GM10135 GM10276 GM12817 GM13046 GM13668 GM14727 GM15538 GM15563 GM17171 GM23357 GM24441 GM25511 GM30446 HL01093 LD03032 LD03986 LD05294 LD06175 LD06879 LD07504 LD09168 LD09670 LD10089 LD10520 LD11417 LD12205 LD12478 LD14489 LD14793 LD18790 LD23136 LD23242 LD25394 LD25720 LD25905 LD26166 LD26628 LD26891 LD28016 LD28387 LD29095 LD30890 LD30912 LD35575 LD35634 LD35684 LD37188 LD37340 LD37576 LD37586 LD38110 LD38361 LD39274 LD39682 LD39824 LD40270 LD40743 LD40813 LD41145 LD41960 LD42775 LD43215 LD43385