FB2025_05 , released December 11, 2025
Gene: Dmel\eIF4A
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General Information
Symbol
Dmel\eIF4A
Species
D. melanogaster
Name
eukaryotic translation initiation factor 4A
Annotation Symbol
CG9075
Feature Type
protein_coding_gene
FlyBase ID
FBgn0001942
Gene Model Status
Current
Stock Availability
25 publicly available
Enzyme Name (EC)
RNA helicase (3.6.4.13)
Gene Summary
eukaryotic translation initiation factor 4A (eIF4A) encodes an essential DEAD-box RNA helicase protein and a canonical translation initiation factor. It is a component of the eIF4F cap-binding complex that is essential for cap-dependent translation of mRNA. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

eIF-4a, l(2)gdh-4, l(2L)162, l(2)k01501, Su(dpp)YE9

Key Links
Genomic Location
Cytogenetic map
26B2-26B2
Sequence location
Recombination map
2-18
RefSeq locus
NT_033779 REGION:5981764..5985909
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (20 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables SMAD binding
inferred from physical interaction with FLYBASE:Mad; FB:FBgn0011648
(Li and Li, 2006)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR011545, InterPro:IPR044728
(InterPro Project Members, 2004-)
enables nucleic acid binding
inferred from electronic annotation with InterPro:IPR011545
(InterPro Project Members, 2004-)
enables RNA helicase activity
inferred from sequence or structural similarity with SGD:S000003674
(Lasko, 2000)
inferred from electronic annotation with InterPro:IPR014014
(InterPro Project Members, 2004-)
enables translation initiation factor activity
inferred from sequence or structural similarity
(Lasko, 2000)
inferred from biological aspect of ancestor with PANTHER:PTN002777147
(GO Reference Genome Project, 2011-)
Biological Process (10 terms)
Terms Based on Experimental Evidence (8 terms)
CV Term
Evidence
References
involved_in female germ-line stem cell asymmetric division
inferred from mutant phenotype
(Shen et al., 2009)
inferred from genetic interaction with FLYBASE:bam; FB:FBgn0000158
(Shen et al., 2009)
involved_in germ-line stem cell population maintenance
inferred from mutant phenotype
(Shen et al., 2009)
involved_in mitotic cell cycle
inferred from high throughput mutant phenotype
(Ducat et al., 2008)
involved_in negative regulation of BMP signaling pathway
inferred from direct assay
(Li and Li, 2006)
inferred from mutant phenotype
(Li and Li, 2006)
involved_in oogenesis
inferred from genetic interaction with FLYBASE:bam; FB:FBgn0000158
(Shen et al., 2009)
inferred from mutant phenotype
(Jagut et al., 2013)
involved_in pole cell formation
inferred from genetic interaction with FLYBASE:tud; FB:FBgn0003891
(Thomson et al., 2008)
inferred from genetic interaction with FLYBASE:vas; FB:FBgn0283442
(Thomson et al., 2008)
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process
inferred from direct assay
(Li and Li, 2006)
involved_in regulation of alternative mRNA splicing, via spliceosome
inferred from high throughput mutant phenotype
(Park et al., 2004)
inferred from mutant phenotype
(Katzenberger et al., 2009)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in cytoplasmic translational initiation
inferred from biological aspect of ancestor with PANTHER:PTN002777147
(GO Reference Genome Project, 2011-)
involved_in translational initiation
inferred from sequence or structural similarity
(Lasko, 2000)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in cytosol
inferred from direct assay
(Li and Li, 2006)
located_in nucleus
inferred from high throughput direct assay
(Lee et al., 2014)
located_in P granule
inferred from direct assay
(Thomson et al., 2008)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
is_active_in cytoplasmic stress granule
inferred from biological aspect of ancestor with PANTHER:PTN002777147
(GO Reference Genome Project, 2011-)
located_in cytosol
inferred from sequence or structural similarity
(Lasko, 2000)
part_of eukaryotic translation initiation factor 4F complex
inferred from sequence or structural similarity
(Lasko, 2000)
located_in nucleus
inferred by curator from GO:0000381
(Park et al., 2004)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
Belongs to the DEAD box helicase family. eIF4A subfamily. (Q02748)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
RNA helicase activity
ATP + H2O = ADP + phosphate + H(+) (3.6.4.13)
Summaries
Gene Snapshot
eukaryotic translation initiation factor 4A (eIF4A) encodes an essential DEAD-box RNA helicase protein and a canonical translation initiation factor. It is a component of the eIF4F cap-binding complex that is essential for cap-dependent translation of mRNA. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
CYTOPLASMIC TRANSLATION INITIATION FACTORS -
Cytoplasmic (or eukaryotic) translation initiation factors function in the initiation stage of ribosome-mediated translation in the cytoplasm. (Adapted from FBrf0233552 and PMID:20094052).
DEAD-BOX RNA HELICASES -
DEAD-box RNA helicases belong to helicase superfamily 2 (SF2). They are characterized by the presence of nine conserved helicase motifs, including the DEAD sequence in motif II. (Adapted from PMID:21509200.)
Pathway (FlyBase)
NEGATIVE REGULATORS OF BMP SIGNALING PATHWAY -
Negative regulators of Bone Morphogenetic Protein (BMP) signaling down-regulate the pathway, ultimately resulting in the decreased nuclear activity of the Mad/Med transcription factor complex.
Protein Function (UniProtKB)
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. As a result, promotes cell proliferation and growth (By similarity). Binds and antagonises the bam-bgcn complex; probably prevents bam mediated translational repression of shg/E-cadherin (PubMed:19556547). Involved in germ cell formation (PubMed:18590813). Involved in germline stem cell maintenance and proliferation; prevents differentiation (PubMed:19556547).
(UniProt, Q02748)
Summary (Interactive Fly)

dead-box RNA helicase - eIF3 complex and the helicase eIF4A are required for dendritic pruning - inactivates TORC1 in response to amino acid starvation - resistance to eIF4A inhibition in conferred by the insulin receptor cellular IRES - controls germline stem cell self-renewal by directly inhibiting BAM function in the ovary - negative regulator of Dpp/BMP signalling that mediates SMAD degradation

Gene Model and Products
Number of Transcripts
6
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\eIF4A for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q02748)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.55

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.44

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
eIF4A-RA
FBtr0079175
NM_164668
1691
403
eIF4A-RB
FBtr0079177
NM_164669
1847
403
eIF4A-RC
FBtr0079176
NM_057247
1553
403
eIF4A-RD
FBtr0079178
NM_164670
1960
403
eIF4A-RE
FBtr0307068
NM_001258978
2021
403
eIF4A-RF
FBtr0331201
NM_001273188
1939
403
Additional Transcript Data and Comments
Reported size (kB)

1.9, 1.75 (northern blot)

(Dorn et al., 1993)

2.2, 2.0 (northern blot)

(Cooley et al., 1992)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
eIF4A-PA
FBpp0078806
45.9
403
5.34
Q02748
NP_723137
AAF52317
eIF4A-PB
FBpp0078808
45.9
403
5.34
Q02748
NP_723138
AAN10567
eIF4A-PC
FBpp0078807
45.9
403
5.34
Q02748
NP_476595
AAN10566
eIF4A-PD
FBpp0078809
45.9
403
5.34
Q02748
NP_723139
AAN10568
eIF4A-PE
FBpp0297911
45.9
403
5.34
Q02748
NP_001245907
AFH03581
eIF4A-PF
FBpp0303628
45.9
403
5.34
Q02748
NP_001260117
AGB92653
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

403 aa isoforms: eIF4A-PA, eIF4A-PB, eIF4A-PC, eIF4A-PD, eIF4A-PE, eIF4A-PF
Additional Polypeptide Data and Comments
Reported size (kDa)

402 (aa)

(Dorn et al., 1993)
Comments
External Data
Subunit Structure (UniProtKB)

eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions (PubMed:18590813). It is composed of at least eIF4A, eIF4E1 and eIF4G1. Interacts with tud and vas (PubMed:18590813). Interacts (via multiple contacts) with bam; the interaction is direct (PubMed:19556547).

(UniProt, Q02748)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\eIF4A using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.56

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism | ubiquitous | uniform
(Hernandez et al., 2004)
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | ubiquitous
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism | ubiquitous
(Dorn et al., 1993)
embryonic stage -- adult stage
(Dorn et al., 1993)
organism
(Hernandez et al., 2004)
Additional Descriptive Data

eIF4A transcripts are detected at all developmental stages. In embryos, they are already present in large amounts in fertilized eggs and are abundant in all tissues at later stages of development.

(Dorn et al., 1993)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
organism | ubiquitous | uniform
(Hernandez et al., 2004)
embryonic stage 5
organism
(Hernandez et al., 2004)
third instar larval stage
wing disc | ubiquitous | uniform
(Hernandez et al., 2004)
haltere disc | ubiquitous | uniform
(Hernandez et al., 2004)
leg disc | ubiquitous | uniform
(Hernandez et al., 2004)
eye-antennal disc | ubiquitous | uniform
(Hernandez et al., 2004)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data

eIF4A protein is ubiquitously distributed at all embryonic stages. In cellular blastoderms, protein is significantly accumulated in the apical cortex of blastoderm cells. eIF4A protein is evenly distributed in wing, haltere, leg, and eye-antennal discs.

(Hernandez et al., 2004)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytosol
inferred from direct assay
(Li and Li, 2006)
located_in nucleus
inferred from high throughput direct assay
(Lee et al., 2014)
located_in P granule
inferred from direct assay
(Thomson et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\eIF4A in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 64 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of eIF4A
Transgenic constructs containing regulatory region of eIF4A
Aberrations (Deficiencies and Duplications) ( 27 )
Inferred from experimentation ( 27 )
Gene disrupted in
Df(2L)BSC184
(Christensen and Cook, 2006.8.29)
Df(2L)chic-106
(Verheyen and Cooley, 1994)
Df(2L)chic-112
(Verheyen and Cooley, 1994)
Df(2L)chic-129
(Verheyen and Cooley, 1994)
Df(2L)chic38
(Verheyen and Cooley, 1994)
Df(2L)chic103
(Verheyen and Cooley, 1994)
Df(2L)chic139
(Verheyen and Cooley, 1994)
Df(2L)cl-h3
(Spradling et al., 1999, BDGP Project Members, 1994-1999)
Df(2L)E110
(Li et al., 2005, Spradling et al., 1999, BDGP Project Members, 1994-1999)
Df(2L)ED299
(Marygold et al., 2007)
Df(2L)ED354
(Marygold et al., 2007)
Df(2L)ED385
(Marygold et al., 2007)
Df(2L)Exel8017
(Ryder, 2004.4.26)
Df(2L)Gpdh1-A
(Li et al., 2005, Spradling et al., 1999, Beaton, 1997.3.4, BDGP Project Members, 1994-1999, Dorn et al., 1993, Kotarski et al., 1983)
Ts(YLt;2Lt)H69+Ts(YLt;2Rt)D211
(Kotarski et al., 1983)
Gene not disrupted in
Df(2L)2802
(Kotarski et al., 1983)
Df(2L)ade2-3
(BDGP Project Members, 1994-1999)
Df(2L)cl1
(Kotarski et al., 1983)
Df(2L)cl2
(Kotarski et al., 1983)
Df(2L)cl7
(Dorn et al., 1993, Kotarski et al., 1983)
Df(2L)Gpdh1-75
(Kotarski et al., 1983)
Df(2L)Gpdh1-78
(Kotarski et al., 1983)
Df(2L)TW161
(BDGP Project Members, 1994-1999)
Df(2R)M60E
(BDGP Project Members, 1994-1999)
Df(2R)Np3
(BDGP Project Members, 1994-1999)
Df(2R)Np5
(BDGP Project Members, 1994-1999)
Df(2R)Pu-D17
(BDGP Project Members, 1994-1999)
Inferred from location ( 14 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4btl.PS
lethal, with Scer\GAL4GMR.PU
lethal, with Scer\GAL4nub-AC-62
lethal, with Scer\GAL4pnr-MD237
lethal (with Df(2L)Gpdh1-A)
lethal | embryonic stage (with Df(2L)E110)
lethal | female limited, with Scer\GAL4dome-PG14
lethal | first instar larval stage (with Df(2L)E110)
lethal | first instar larval stage (with eIF4A02439)
lethal | first instar larval stage (with eIF4AYE9)
lethal | pupal stage, with Scer\GAL4pnr-MD237
lethal | recessive
lethal | second instar larval stage (with Df(2L)E110)
lethal | second instar larval stage (with eIF4A02439)
lethal | second instar larval stage (with eIF4AYE9)
lethal | third instar larval stage (with Df(2L)E110)
lethal - all die before end of larval stage, with Scer\GAL4en-e16E
lethal - all die before end of larval stage | recessive
lethal - all die before end of P-stage, with Scer\GAL4GMR.PU
lethal - all die before end of P-stage, with Scer\GAL4nub.PK
lethal - all die during embryonic stage, with Scer\GAL4nub.PK
lethal - all die during embryonic stage | recessive
lethal - all die during larval stage, with Scer\GAL4Mef2.PR
partially lethal, with Scer\GAL4tin.CΔ4
partially lethal - majority die | recessive
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
Other Phenotypes
Allele
abnormal cell number | somatic clone | spermatogenesis
abnormal developmental rate | dominant | larval stage
abnormal mitotic cell cycle | recessive
abnormal neuroanatomy, with Scer\GAL4elav-C155
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4repo
decreased cell number | cell autonomous | larval stage | somatic clone
decreased cell number | germline clone
decreased cell number | spermatogenesis, with Scer\GAL4tj.PU
decreased cell number | third instar larval stage, with Scer\GAL4repo
decreased occurrence of cell division | larval stage
some die during embryonic stage | recessive
some die during larval stage, with Scer\GAL4tin.CΔ4
some die during larval stage | recessive
visible | adult stage, with Scer\GAL4nub.PK
Phenotype manifest in
Allele
amnioserosa
amnioserosa (with Df(2L)Gpdh1-A)
anterior fascicle & synapse, with Scer\GAL4elav-C155
centrosome | germline clone
cephalopharyngeal skeleton
cuticle
cyst progenitor cell | decreased number, with Scer\GAL4tj.PU
cyst progenitor cell | decreased number | somatic clone
egg chamber | germline clone
embryonic/first instar larval cuticle
embryonic/larval optic stalk | third instar larval stage, with Scer\GAL4repo
embryonic/larval salivary gland, with Scer\GAL4fkh.PH
eye
eye disc | third instar larval stage, with Scer\GAL4repo
female germline stem cell | germline clone
glial cell | third instar larval stage, with Scer\GAL4repo
head
larval intersegmental nerve, with Scer\GAL4elav-C155
oocyte | germline clone
parasegment 1
parasegment 2
parasegment 3
parasegment 4
parasegment 5
parasegment 6
parasegment 7
parasegment 8
parasegment 9
parasegment 10
parasegment 11
parasegment 12
parasegment 13
parasegment 14
parasegment 15
wing, with Scer\GAL4nub.PK
wing disc
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (27)
Hsap\EIF4A1
13 of 14
Yes
Yes
Hsap\EIF4A2
13 of 14
Yes
Yes
 
5  
Hsap\EIF4A3
5 of 14
No
No
Hsap\DDX1
1 of 14
No
No
2  
Hsap\DDX3X
1 of 14
No
No
1  
Hsap\DDX3Y
1 of 14
No
No
Hsap\DDX4
1 of 14
No
No
Hsap\DDX5
1 of 14
No
No
1  
Hsap\DDX6
1 of 14
No
No
Hsap\DDX10
1 of 14
No
No
1  
Hsap\DDX17
1 of 14
No
No
1  
Hsap\DDX19A
1 of 14
No
No
Hsap\DDX19B
1 of 14
No
No
Hsap\DDX20
1 of 14
No
No
Hsap\DDX23
1 of 14
No
No
Hsap\DDX25
1 of 14
No
No
Hsap\DDX27
1 of 14
No
No
Hsap\DDX39A
1 of 14
No
No
1  
Hsap\DDX39B
1 of 14
No
No
0  
Hsap\DDX42
1 of 14
No
No
Hsap\DDX43
1 of 14
No
No
Hsap\DDX47
1 of 14
No
No
Hsap\DDX49
1 of 14
No
No
Hsap\DDX50
1 of 14
No
No
Hsap\DDX52
1 of 14
No
No
Hsap\DDX54
1 of 14
No
No
Hsap\DDX56
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (13)
Rnor\Eif4a1
13 of 14
Yes
Yes
Rnor\Eif4a2
13 of 14
Yes
Yes
Rnor\Eif4a3
5 of 14
No
No
Rnor\Ddx1
1 of 14
No
No
Rnor\Ddx6
1 of 14
No
No
Rnor\Ddx19b
1 of 14
No
No
Rnor\Ddx23
1 of 14
No
No
Rnor\Ddx25
1 of 14
No
No
Rnor\Ddx39a
1 of 14
No
No
Rnor\Ddx39b
1 of 14
No
No
Rnor\Ddx42
1 of 14
No
No
Rnor\Ddx52
1 of 14
No
No
Rnor\Ddx54
1 of 14
No
No
Mus musculus (laboratory mouse) (16)
Mmus\Eif4a1
13 of 14
Yes
Yes
Mmus\Eif4a2
13 of 14
Yes
Yes
Mmus\Eif4a3
5 of 14
No
No
Mmus\Eif4a3l1
4 of 14
No
No
Mmus\Eif4a3l2
4 of 14
No
No
Mmus\Ddx1
1 of 14
No
No
Mmus\Ddx6
1 of 14
No
No
Mmus\Ddx19a
1 of 14
No
No
Mmus\Ddx19b
1 of 14
No
No
Mmus\Ddx23
1 of 14
No
No
Mmus\Ddx25
1 of 14
No
No
Mmus\Ddx39a
1 of 14
No
No
Mmus\Ddx39b
1 of 14
No
No
Mmus\Ddx42
1 of 14
No
No
Mmus\Ddx52
1 of 14
No
No
Mmus\Ddx54
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (12)
Xtro\eif4a1
7 of 13
Yes
Yes
Xtro\eif4a2
7 of 13
Yes
Yes
Xtro\eif4a3.1
5 of 13
No
No
Xtro\ddx1
1 of 13
No
No
Xtro\ddx6
1 of 13
No
No
Xtro\ddx10
1 of 13
No
No
Xtro\ddx27
1 of 13
No
No
Xtro\ddx42
1 of 13
No
No
Xtro\ddx54
1 of 13
No
No
Xtro\ddx56
1 of 13
No
No
Xtro\ddx59
1 of 13
No
No
Xtro\nphs2
1 of 13
No
No
Danio rerio (Zebrafish) (15)
Drer\eif4a1b
12 of 14
Yes
Yes
Drer\eif4a2
12 of 14
Yes
Yes
Drer\eif4a1a
11 of 14
No
Yes
Drer\eif4a3
5 of 14
No
No
Drer\ddx1
1 of 14
No
No
Drer\ddx6
1 of 14
No
No
Drer\ddx19a
1 of 14
No
No
Drer\ddx19b
1 of 14
No
No
Drer\ddx23
1 of 14
No
No
Drer\ddx39aa
1 of 14
No
No
Drer\ddx39ab
1 of 14
No
No
Drer\ddx39b
1 of 14
No
No
Drer\ddx52
1 of 14
No
No
Drer\ddx54
1 of 14
No
No
Drer\ddx61
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (18)
Cele\inf-1
13 of 14
Yes
Yes
Cele\F57B9.3
7 of 14
No
Yes
Cele\F33D11.10
5 of 14
No
No
Cele\Y65B4A.6
5 of 14
No
No
Cele\mel-46
2 of 14
No
No
Cele\B0511.6
1 of 14
No
No
Cele\C24H12.4
1 of 14
No
No
Cele\cgh-1
1 of 14
No
No
Cele\ddx-17
1 of 14
No
No
Cele\ddx-19
1 of 14
No
No
Cele\ddx-27
1 of 14
No
No
Cele\ddx-46
1 of 14
No
No
Cele\H20J04.4
1 of 14
No
No
Cele\hel-1
1 of 14
No
No
Cele\sacy-1
1 of 14
No
No
Cele\T26G10.1
1 of 14
No
No
Cele\Y55F3BR.1
1 of 14
No
No
Cele\Y94H6A.5
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (24)
Agam\AgaP_AGAP009863
12 of 12
Yes
Yes
Agam\AgaP_AGAP003089
5 of 12
No
No
Agam\AgaP_AGAP005391
2 of 12
No
No
Agam\AgaP_AGAP003047
1 of 12
No
No
Agam\AgaP_AGAP003397
1 of 12
No
No
Agam\AgaP_AGAP003663
1 of 12
No
No
Agam\AgaP_AGAP004351
1 of 12
No
No
Agam\AgaP_AGAP004711
1 of 12
No
No
Agam\AgaP_AGAP004765
1 of 12
No
No
Agam\AgaP_AGAP004912
1 of 12
No
No
Agam\AgaP_AGAP005130
1 of 12
No
No
Agam\AgaP_AGAP005652
1 of 12
No
No
Agam\AgaP_AGAP007511
1 of 12
No
No
Agam\AgaP_AGAP008578
1 of 12
No
No
Agam\AgaP_AGAP008601
1 of 12
No
No
Agam\AgaP_AGAP009075
1 of 12
No
No
Agam\AgaP_AGAP009135
1 of 12
No
No
Agam\AgaP_AGAP009808
1 of 12
No
No
Agam\AgaP_AGAP011084
1 of 12
No
No
Agam\AgaP_AGAP011145
1 of 12
No
No
Agam\AgaP_AGAP011147
1 of 12
No
No
Agam\AgaP_AGAP012358
1 of 12
No
No
Agam\AgaP_AGAP012523
1 of 12
No
No
Agam\AgaP_AGAP012892
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (39)
Atha\EIF4A1
13 of 13
Yes
Yes
Atha\EIF4A-2
13 of 13
Yes
Yes
Atha\AT1G72730
12 of 13
No
Yes
Atha\AT1G51380
5 of 13
No
No
Atha\EIF4A-III
5 of 13
No
No
Atha\AT1G20920
1 of 13
No
No
Atha\AT1G77030
1 of 13
No
No
Atha\AT2G33730
1 of 13
No
No
Atha\AT2G42520
1 of 13
No
No
Atha\AT2G45810
1 of 13
No
No
Atha\AT2G47330
1 of 13
No
No
Atha\AT3G02065
1 of 13
No
No
Atha\AT3G06480
1 of 13
No
No
Atha\AT3G09720
1 of 13
No
No
Atha\AT3G58510
1 of 13
No
No
Atha\AT3G58570
1 of 13
No
No
Atha\AT3G61240
1 of 13
No
No
Atha\AT4G16630
1 of 13
No
No
Atha\AT4G33370
1 of 13
No
No
Atha\AT4G34910
1 of 13
No
No
Atha\AT4G37020
1 of 13
No
No
Atha\AT5G14610
1 of 13
No
No
Atha\AT5G19210
1 of 13
No
No
Atha\AT5G51280
1 of 13
No
No
Atha\AT5G60990
1 of 13
No
No
Atha\AT5G63120
1 of 13
No
No
Atha\DRH1
1 of 13
No
No
Atha\emb1138
1 of 13
No
No
Atha\EMB1586
1 of 13
No
No
Atha\LOS4
1 of 13
No
No
Atha\PMH1
1 of 13
No
No
Atha\PMH2
1 of 13
No
No
Atha\RH8
1 of 13
No
No
Atha\RH20
1 of 13
No
No
Atha\RH36
1 of 13
No
No
Atha\RPF1
1 of 13
No
No
Atha\STRS1
1 of 13
No
No
Atha\UAP56a
1 of 13
No
No
Atha\UAP56b
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (15)
Scer\TIF1
11 of 13
Yes
Yes
Scer\TIF2
10 of 13
No
Yes
Scer\FAL1
5 of 13
No
No
Scer\DBP1
1 of 13
No
No
Scer\DBP2
1 of 13
No
No
Scer\DBP3
1 of 13
No
No
Scer\DBP5
1 of 13
No
No
Scer\DBP8
1 of 13
No
No
Scer\DBP9
1 of 13
No
No
Scer\DED1
1 of 13
No
No
Scer\DHH1
1 of 13
No
No
Scer\DRS1
1 of 13
No
No
Scer\PRP28
1 of 13
No
No
Scer\RRP3
1 of 13
No
No
Scer\SUB2
1 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (8)
Spom\SPAC1006.07
10 of 12
Yes
Yes
Spom\SPAC1F5.10
4 of 12
No
No
Spom\dbp3
1 of 12
No
No
Spom\rok1
1 of 12
No
No
Spom\SPBC12C2.06
1 of 12
No
No
Spom\SPBC25D12.06
1 of 12
No
Yes
Spom\ste13
1 of 12
No
No
Spom\uap56
1 of 12
No
No
Escherichia coli (enterobacterium) (3)
Ecol\deaD
5 of 11
Yes
No
Ecol\rhlE
3 of 11
No
No
Ecol\dbpA
2 of 11
No
No
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:eIF4A. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (31)
CG7483
8 of 13
me31B
4 of 13
ais
3 of 13
CG5800
3 of 13
CG6418
3 of 13
CG32344
3 of 13
Dbp45A
3 of 13
Ddx1
3 of 13
Ddx56
3 of 13
Gem3
3 of 13
pths
3 of 13
Rs1
3 of 13
bel
2 of 13
CG7878
2 of 13
CG8611
2 of 13
CG9143
2 of 13
CG9630
2 of 13
CG10077
2 of 13
CG10333
2 of 13
Dbp21E2
2 of 13
Dbp73D
2 of 13
Dbp80
2 of 13
Hel25E
2 of 13
mahe
2 of 13
pit
2 of 13
Prp5
2 of 13
Rm62
2 of 13
vas
2 of 13
abs
1 of 13
CG14443
1 of 13
mus301
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 1 )
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
EIF4A1; eukaryotic translation initiation factor 4A1
13 of 14
602641
      EIF4A2; eukaryotic translation initiation factor 4A2
      13 of 14
      EUKARYOTIC TRANSLATION INITIATION FACTOR 4A, ISOFORM 2; EIF4A2
       
      EIF4A3; eukaryotic translation initiation factor 4A3
      5 of 14
      608546
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Dmel gene
        Ortholog showing functional complementation
        Supporting References
        eIF4A
        Hsap\EIF4A2
        (Paul et al., 2023)
        Interactions
        Summary of Physical Interactions
        Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        eIF4A - Akt
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        eIF4A - Mad
        anti tag coimmunoprecipitation, anti tag western blot, pull down, western blot, anti bait coimmunoprecipitation
        (Li and Li, 2006)
        eIF4A - Med
        anti tag coimmunoprecipitation, anti tag western blot
        (Li and Li, 2006)
        eIF4A - NAT1
        anti tag coimmunoprecipitation, anti tag western blot, peptide massfingerprinting
        (Tsokanos et al., 2016)
        eIF4A - Pdcd4
        pull down, western blot, anti bait coimmunoprecipitation, anti tag western blot
        (Olson et al., 2013)
        eIF4A - Pdk1
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        eIF4A - Pi3K92E
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        eIF4A - Raf
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Friedman et al., 2011)
        eIF4A - RagC-D
        anti tag coimmunoprecipitation, anti tag western blot
        (Tsokanos et al., 2016)
        eIF4A - Rheb
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        eIF4A - S6k
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        eIF4A - S6kII
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        eIF4A - aub
        anti tag coimmunoprecipitation, anti tag western blot, cross-linking study, Identification by mass spectrometry
        (Ma et al., 2017, Zheng et al., 2016)
        eIF4A - bam
        anti tag coimmunoprecipitation, anti tag western blot, two hybrid
        (Shen et al., 2009)
        eIF4A - csw
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Friedman et al., 2011)
        eIF4A - eIF3b
        anti tag coimmunoprecipitation, western blot
        (Rode et al., 2018)
        eIF4A - eIF4G1
        two hybrid
        (Hernandez et al., 2004)
        eIF4A - gig
        anti tag coimmunoprecipitation, Identification by mass spectrometry, anti tag western blot
        (Tsokanos et al., 2016, Vinayagam et al., 2016)
        eIF4A - raptor
        anti tag coimmunoprecipitation, anti tag western blot
        (Tsokanos et al., 2016)
        eIF4A - rictor
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        eIF4A - sima
        anti tag coimmunoprecipitation, Identification by mass spectrometry
        (Vinayagam et al., 2016)
        eIF4A - tud
        anti tag coimmunoprecipitation, anti tag western blot, cross-linking study, Identification by mass spectrometry, anti bait coimmunoprecipitation
        (Zheng et al., 2016, Thomson et al., 2008)
        Summary of Genetic Interactions
        Interaction Browsers
        View in FlyBase Interactions Browser   View in MIST tool (external link)
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        bam
        suppressible
        eIF4A
        (Shen et al., 2009)
        bam
        enhanceable
        eIF4A
        (Shen et al., 2009)
        ct
        enhanceable
        eIF4A
        (Krupp et al., 2005)
        ct
        suppressible
        eIF4A
        (Krupp et al., 2005)
        dpp
        suppressible
        eIF4A
        (Li et al., 2005)
        Dref
        suppressible
        eIF4A
        (Ida et al., 2009, Ida et al., 2007)
        l(1)sc
        enhanceable
        eIF4A
        (Rottgen et al., 1998)
        N
        enhanceable
        eIF4A
        (Rottgen et al., 1998)
        Pdcd4
        suppressible
        eIF4A
        (Cash and Andrews, 2012)
        peb
        suppressible
        eIF4A
        (Wilk et al., 2004)
        Pten
        suppressible
        eIF4A
        (Gao et al., 2000)
        External Data
        Subunit Structure (UniProtKB)
        eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions (PubMed:18590813). It is composed of at least eIF4A, eIF4E1 and eIF4G1. Interacts with tud and vas (PubMed:18590813). Interacts (via multiple contacts) with bam; the interaction is direct (PubMed:19556547).
        (UniProt, Q02748 )
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Class of Gene
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2L
        Recombination map
        2-18
        Cytogenetic map
        26B2-26B2
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        26B2-26B2
        Limits computationally determined from genome sequence between P{EP}chicEP713&P{EP}chicEP1095 and P{lacW}Gef26k13720
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        25D5-26D1
        (Li and Gelbart, 2002)
        26B1-26B2
        (determined by in situ hybridisation)
        (Spradling et al., 1999)
        26A5-26A7
        26A5--8 26A7--8 26A7--9 26A8--9 26B1--2 26B8--9
        (BDGP Project Members, 1994-1999)
        26A7-26A9
        (determined by in situ hybridisation) 27A7--27A9 (determined by in situ hybridisation)
        (Dorn et al., 1993)
        Experimentally Determined Recombination Data
        Location

        2-18

        (FlyBase, 2016)

        2-19.2

        (Comeron et al., 2012)
        Left of (cM)
        (Li et al., 2005)
        Right of (cM)
        (Li et al., 2005)
        Notes
        Stocks and Reagents
        Stocks (25)
        Genomic Clones (18)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (890)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        Antibody Information
        Laboratory Generated Antibodies
         

        polyclonal

        (Tsokanos et al., 2016, Fukaya et al., 2014, Olson et al., 2013, Hernandez et al., 2004)

        monoclonal

        (Na et al., 2016)
        Commercially Available Antibodies
         
        Cell Line Information
        Publicly Available Cell Lines
         
          Other Stable Cell Lines
           
            Other Comments

            RNAi screen using dsRNA made from templates generated with primers directed against this gene results in aberrantly short, monopolar spindles when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA.

            (Goshima et al., 2007)

            S2 cells transfected with dsRNA made from templates generated with primers directed against this gene show significantly lower levels of global translation within 2 days.

            (Coelho et al., 2005)

            RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells.

            (Boutros et al., 2004)

            Identification: identified in a genetic screen for suppressors of the dppH46 phenotype.

            (Li and Gelbart, 2002)

            Maternal and zygotic suppressor of dppH46. Homozygous embryonic lethal. Cuticle phenotypes of homozygous mutant embryos show dorsal-ventral patterning defects. eIF-4a can completely rescue the maternal-effect lethality caused by Mad, sax double mutants.

            (Li and Gelbart, 2002)

            Identification: One of a collection of genes identified with defective larval growth that extend larval life.

            (Galloni and Edgar, 1999)

            Identification: Enhancer trap expression pattern survey for loci expressed in the ring gland.

            (Harvie et al., 1998)

            Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology.

            (Roch et al., 1998)

            A single copy gene.

            (Dorn et al., 1993)

            1.6kb non-sex-specific transcript located close to Acp26Aa in the 26A region.

            (Monsma and Wolfner, 1988)
            Relationship to Other Genes
            Source for database merge of

            Source for merge of: eIF-4a l(2)k01501

            (Spradling et al., 1999)

            Source for merge of: eIF-4a Su(dpp)YE9

            (Li et al., 2005)
            Additional comments
            Nomenclature History
            Source for database identify of

            Source for identity of: eIF4A eIF-4a

            (Marygold et al., 2017)
            Nomenclature comments
            Etymology
            Synonyms and Secondary IDs (42)
            Reported As
            Symbol Synonym
            2439
            (Harvie et al., 1998)
            9075
            (Ravi et al., 2009)
            CG9075
            (National Institute of Genetics Fly Stocks, 2022-, Vasudevan et al., 2020, Kolkhof et al., 2017, Marygold et al., 2017, Na et al., 2016, Hosono et al., 2015, Povellato et al., 2014, Schertel et al., 2013, Cammarato et al., 2011, Müller et al., 2010, Ni et al., 2010.12.1, Ida et al., 2009, Keleman et al., 2009.8.5, Ducat et al., 2008, Hughes et al., 2008, Goshima et al., 2007, Quinones-Coello, 2007, McIntyre et al., 2006, Molnar et al., 2006, Hernandez et al., 2004, Kraut et al., 2001, Kraut et al., 2001, Lasko, 2000, Whitfield, 2000.5.17)
            Dm-eIF4A
            (Hernandez et al., 2004)
            DmRH2
            (Boudet et al., 2001)
            EIF-4A
            (Hernandez et al., 2004, Boudet et al., 2001)
            EIF-4a
            (He et al., 2014, Povellato et al., 2014)
            EIF4A
            (Cui et al., 2020, Linsalata et al., 2019, Sofola et al., 2007)
            EiF4A
            (Weinkove and Leevers, 2000)
            Eif-4a
            (Morin et al., 2001)
            Eif4a
            (Nguyen et al., 2016)
            IF4A
            (Beghelli et al., 2024)
            L(2L)162
            (Hernandez et al., 2004)
            Su(dpp)YE9
            (Li and Gelbart, 2002)
            anon-26Aa
            anon26A
            deIF4A
            (Gareau et al., 2013, Garrey et al., 2010)
            eIF 4A
            (Ducat et al., 2008)
            eIF-4A
            (Chen et al., 2013, Kent et al., 2009, Fuller and Baker, 2007.6.28, Beller et al., 2006, Takahashi et al., 2005, van Steensel et al., 2001)
            eIF-4a
            (Hudson et al., 2023, National Institute of Genetics Fly Stocks, 2022-, Grobler et al., 2018, Jana et al., 2016, Na et al., 2016, Sarov et al., 2016, Tan et al., 2016, Dent et al., 2015, Tavares et al., 2015, Vedanayagam and Garrigan, 2015, Ashwal-Fluss et al., 2014, Demontis et al., 2014, Lee et al., 2014, Bonke et al., 2013, Kwon et al., 2013, Schertel et al., 2013, Sen et al., 2013, Franco et al., 2011, Friedman et al., 2011, Müller et al., 2010, Müller et al., 2010, Ulvila et al., 2010, Ida et al., 2009, Jiang et al., 2009, Katzenberger et al., 2009, Maybeck and Röper, 2009, Fisher et al., 2008, Zhou et al., 2008, Buszczak et al., 2007, Goshima et al., 2007, Ida et al., 2007, Marygold et al., 2007, Quinones-Coello, 2007, Stuart et al., 2007, Sun et al., 2007, Christensen and Cook, 2006.8.29, McIntyre et al., 2006, Molnar et al., 2006, Lipatov et al., 2005, Wang et al., 2004)
            eIF-4a-I
            (Hernandez and Vazquez-Pianzola, 2005)
            eIF4A
            (Dyson et al., 2025, Rui, 2024, Zappia et al., 2024, Paul et al., 2023, Furusawa and Emoto, 2021, Millet-Boureima et al., 2021, Morin-Poulard et al., 2021, Jin et al., 2020, Thackray et al., 2020, Vasudevan et al., 2020, Drummond-Barbosa, 2019, Fingerhut et al., 2019, Gene Disruption Project members, 2018-, Rode et al., 2018, Ma et al., 2017, Marygold et al., 2017, Zheng et al., 2016, Tokusumi et al., 2015, Gareau et al., 2013, Hernández et al., 2013, Jagut et al., 2013, Olson et al., 2013, Cash and Andrews, 2012, Penney et al., 2012, Tokusumi et al., 2012, Zitserman et al., 2012, Singh et al., 2011, Park et al., 2010, Shen et al., 2009, Thomson et al., 2008, Andersen and Leevers, 2007, Franklin-Dumont et al., 2007, Ida et al., 2007, Bjorklund et al., 2006, Li and Li, 2006, Coelho et al., 2005, Li et al., 2005, Hernandez et al., 2004, Carrera et al., 2000, Lasko, 2000, Lehner, 1999, Verheyen and Cooley, 1994)
            eIF4A-I
            (Hernandez and Vazquez-Pianzola, 2005)
            eIF4AI
            (Palacios et al., 2004)
            eIF4a
            (Pavlidaki et al., 2022, Al L Abaquita et al., 2021, Li et al., 2020, Ji et al., 2017, Olesnicky et al., 2014, Djiane et al., 2013, Blanco et al., 2010, Abel et al., 2009, Insco et al., 2009)
            eIf4A
            (Kagemann et al., 2025)
            eiF4A
            (Ramesh et al., 2023, Sankaranarayanan and Weil, 2020, Jagut et al., 2013)
            eif-4a
            (Basu and Li, 1998)
            eif4A
            (Orian et al., 2003, Gao et al., 2000, Galloni and Edgar, 1999, Galloni and Edgar, 1999)
            eif4a
            (Sofola et al., 2007)
            l(2)02439
            l(2)162
            l(2)26Ac
            l(2)gdh-4
            (Knipple and MacIntyre, 1984, Kotarski et al., 1983)
            l(2)k01501
            (BDGP Project Members, 1994-1999)
            l(2L)162
            (Dorn et al., 1993, Dorn, 1992.10.29)
            pecan
            (Jagut et al., 2013)
            Name Synonyms
            Eukaryotic initiation factor 4A
            (Costello et al., 2009)
            Eukaryotic initiation factor 4a
            (Cammarato et al., 2011)
            eukaryotic initiation factor 4A
            (Jagut et al., 2013, Ida et al., 2007)
            eukaryotic translation initiation factor 4A
            (Kent et al., 2009, Li and Li, 2006)
            translation initiation factor 4A
            (Hernandez et al., 2004)
            Secondary FlyBase IDs
            • FBgn0013406
            • FBgn0013523
            • FBgn0015864
            • FBgn0022247
            • FBgn0024969
            • FBgn0062252
            Datasets (0)
            Study focus (0)
            Experimental Role
            Project
            Project Type
            Title
            Study result (0)
            Result
            Result Type
            Title
            External Crossreferences and Linkouts ( 81 )
            Sequence Crossreferences
            NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
            GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
            GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
            RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
            UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
            UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
            Other crossreferences
            AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
            BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
            DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
            EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
            FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
            FlyMine - An integrated database for Drosophila genomics
            InterPro - A database of protein families, domains and functional sites
            KEGG Genes - Molecular building blocks of life in the genomic space.
            MARRVEL_MODEL - MARRVEL (model organism gene)
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
            DroID - A comprehensive database of gene and protein interactions.
            DRSC - Results frm RNAi screens
            Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
            FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
            FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
            Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
            Flygut - An atlas of the Drosophila adult midgut
            FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
            iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
            Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
            MIST (genetic) - An integrated Molecular Interaction Database
            MIST (protein-protein) - An integrated Molecular Interaction Database
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            References (228)