FlyBase Gene Report: Dmel\Sos

General Information

Symbol

Dmel\Sos

Species

D. melanogaster

Name

Son of sevenless

Annotation Symbol

CG7793

Feature Type

protein_coding_gene

FlyBase ID

FBgn0001965

Gene Model Status

Stock Availability

20 publicly available

Gene Summary

Promotes the exchange of Ras-bound GDP by GTP. Functions in signaling pathways initiated by the sevenless and epidermal growth factor receptor tyrosine kinases; implies a role for the ras pathway in neuronal development. (UniProt, P26675)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Pathway
Gene Group
UniProtKB
Red Book
Interactive Fly

Also Known As

l(2)br24, l(2)34Ea, dSos, E(sev)2A, Su(tor)2-2

Key Links

Genomic Location

Cytogenetic map

Sequence location

2L:13,813,816..13,819,824 [+]

Recombination map

2-49

RefSeq locus

NT_033779 REGION:13813816..13819824

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (26 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables guanyl-nucleotide exchange factor activity

inferred from direct assay

(McCollam et al., 1995, Baltensperger et al., 1993)

inferred from genetic interaction with FLYBASE:Rac1; FB:FBgn0010333

(Yang and Bashaw, 2006)

inferred from genetic interaction with SGD:S000004301

(Karlovich et al., 1995)

enables protein binding

inferred from physical interaction with FLYBASE:drk; FB:FBgn0004638

(Raabe et al., 1995, Olivier et al., 1993)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables DNA binding

inferred from electronic annotation with InterPro:IPR007125

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables guanyl-nucleotide exchange factor activity

inferred from biological aspect of ancestor with PANTHER:PTN007734601

(assigned by GO_Central )

(Gaudet et al., 2011)

enables protein heterodimerization activity

inferred from electronic annotation with InterPro:IPR009072

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Biological Process (18 terms)

Terms Based on Experimental Evidence (16 terms)

CV Term

Evidence

References

involved_in axon midline choice point recognition

inferred from genetic interaction with FLYBASE:robo1; FB:FBgn0005631, FLYBASE:Rac1; FB:FBgn0010333, FLYBASE:RhoGAP93B; FB:FBgn0038853, FLYBASE:sli; FB:FBgn0264089

(Yang and Bashaw, 2006)

involved_in defense response to virus

inferred from mutant phenotype

(Xu et al., 2013)

involved_in epidermal growth factor receptor signaling pathway

inferred from mutant phenotype

(Cabernard and Affolter, 2005, Lu and Li, 1999, Diaz-Benjumea and Hafen, 1994)

involved_in epithelial cell migration, open tracheal system

inferred from mutant phenotype

(Cabernard and Affolter, 2005)

involved_in fibroblast growth factor receptor signaling pathway

inferred from mutant phenotype

(Cabernard and Affolter, 2005)

involved_in imaginal disc-derived leg morphogenesis

inferred from mutant phenotype

(Greenberg and Hatini, 2011)

involved_in negative regulation of G1/S transition of mitotic cell cycle

inferred from mutant phenotype

(Firth and Baker, 2005)

involved_in photoreceptor cell fate determination

inferred from genetic interaction with FLYBASE:rho; FB:FBgn0004635

(Freeman, 1994)

involved_in positive regulation of cell size

inferred from mutant phenotype

(Sims et al., 2009)

involved_in positive regulation of Rac protein signal transduction

inferred from genetic interaction with FLYBASE:Rac1; FB:FBgn0010333

(Yang and Bashaw, 2006)

involved_in positive regulation of Ras protein signal transduction

inferred from direct assay

(Baltensperger et al., 1993)

involved_in R7 cell fate commitment

inferred from genetic interaction with FLYBASE:sev; FB:FBgn0003366

(Karlovich et al., 1995, Bonfini et al., 1992, Rogge et al., 1991, Simon et al., 1991)

inferred from genetic interaction with FLYBASE:sev; FB:FBgn0003366, FLYBASE:drk; FB:FBgn0004638

(Simon et al., 1993)

involved_in sevenless signaling pathway

inferred from genetic interaction with FLYBASE:sev; FB:FBgn0003366, FLYBASE:drk; FB:FBgn0004638

(Simon et al., 1993)

inferred from genetic interaction with FLYBASE:sev; FB:FBgn0003366

(Karlovich et al., 1995, Bonfini et al., 1992, Simon et al., 1991)

inferred from genetic interaction with FLYBASE:boss; FB:FBgn0000206, FLYBASE:sev; FB:FBgn0003366

(Rogge et al., 1991)

involved_in torso signaling pathway

inferred from mutant phenotype

(Hou et al., 1995, Lu et al., 1993)

inferred from genetic interaction with FLYBASE:tor; FB:FBgn0003733

(Doyle and Bishop, 1993)

involved_in tracheal outgrowth, open tracheal system

inferred from mutant phenotype

(Cabernard and Affolter, 2005)

involved_in vascular endothelial growth factor receptor signaling pathway

inferred from mutant phenotype

(Sims et al., 2009)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in positive regulation of GTPase activity

inferred from biological aspect of ancestor with PANTHER:PTN007734601

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in positive regulation of Ras protein signal transduction

inferred by curator from GO:0005085

(McCollam et al., 1995)

involved_in Ras protein signal transduction

inferred from biological aspect of ancestor with PANTHER:PTN007734601

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

located_in cytosol

inferred from direct assay

(Yang and Bashaw, 2006)

located_in extrinsic component of cytoplasmic side of plasma membrane

inferred from direct assay

(Yang and Bashaw, 2006)

located_in rhabdomere microvillus membrane

inferred from direct assay

(Karlovich et al., 1995)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN007734601

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

RAS GUANINE NUCLEOTIDE EXCHANGE FACTORS

RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS

Pathway (FlyBase)

Torso Signaling Pathway Core Components

Sevenless Signaling Pathway Core Components

EGFR Signaling Pathway Core Components

FGFR Signaling Pathway Core Components

Pvr Signaling Pathway Core Components

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

RAS GUANINE NUCLEOTIDE EXCHANGE FACTORS -: RasGEFs are Guanine Nucleotide Exchange Factors (GEFs) for Ras family GTPases. The RasGEFs are characterized by a CDC25 homology domain. (Adapted from FBrf0220530).
RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS -: RhoGEFs are Guanine Nucleotide Exchange Factors (GEFs) for Rho family GTPases. They include Dbl-homology domain-containing proteins (the largest family of RhoGEFs) and CZH2 domain/Dock family GEFs. (Adapted from FBrf0190957).

Pathway (FlyBase)

Torso Signaling Pathway Core Components -: The formation of Drosophila embryonic termini is controlled by the localized activation of Torso (tor) receptor tyrosine kinase. The Torso signaling pathway acts via the canonical Ras/Raf/MAP kinase cascade. (Adapted from FBrf0157176.)
Sevenless Signaling Pathway Core Components -: The specification of the R7 photoreceptor cell in each ommatidium of the developing Drosophila eye is dependent on activation of Sevenless receptor tyrosine kinase, which acts via the canonical Ras/Raf/MAP kinase cascade to promote the expression of lz and pros. sev, expressed in presumptive R7 cells, is activated by binding to Bride of Sevenless (boss), a seven-transmembrane protein expressed in R8 cells. (Adapted from FBrf0127283 and FBrf0221727).
EGFR Signaling Pathway Core Components -: The Epidermal Growth Factor Receptor (EGFR) signaling pathway is used multiple times during development (FBrf0190321). It is activated by the binding of a secreted ligand to the receptor tyrosine kinase Egfr and acts via the canonical Ras/Raf/MAP kinase (ERK) cascade. (Adapted from FBrf0190321 and FBrf0221727).
FGFR Signaling Pathway Core Components -: Fibroblast Growth Factor Receptor (FGFR) signaling pathway is initiated by the binding of secreted FGFs - bnl or ths/pyr to receptor tyrosine kinases btl or htl, respectively, to initiate signaling primarily via the canonical Ras/Raf/MAP kinase (ERK) cascade. (Adapted from FBrf0221038).
Pvr Signaling Pathway Core Components -: PDGF/VEGF (Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor)-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).

Protein Function (UniProtKB)

Promotes the exchange of Ras-bound GDP by GTP. Functions in signaling pathways initiated by the sevenless and epidermal growth factor receptor tyrosine kinases; implies a role for the ras pathway in neuronal development.

(UniProt, P26675)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

l(2)34Ea

Recessive lethal or semilethal; heteroallelic or hemizygous escapers have small rough eyes; heterozygotes between two weak alleles viable with rough eyes.

Summary (Interactive Fly)

a dual specificity GEF that regulates both Ras and Rho family GTPases - integrates signals that affect gene expression and cytoskeletal reorganization - Slit-dependent endocytic trafficking of the Robo receptor is required for Son of Sevenless recruitment and midline axon repulsion

Interactive Fly

Gene Model and Products

Number of Transcripts

1

Number of Unique Polypeptides

1

Please see the JBrowse view of Dmel\Sos for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P26675)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.45

Gene model reviewed during 6.02

Sequence Ontology: Class of Gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0080541

5635

1596

Additional Transcript Data and Comments

Reported size (kB)

5.5 (longest cDNA)

(Bonfini et al., 1992)

6.0 (northern blot)

(Simon et al., 1991)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

FBpp0080118

177.9

1596

7.42

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

1595 (aa)

(Bonfini et al., 1992)

1596 (aa)

(Simon et al., 1991)

Comments

External Data

Subunit Structure (UniProtKB)

May form a complex with sevenless and DRK.

(UniProt, P26675)

Crossreferences

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

1AZE

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

P26675

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sos using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Sos_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that the Fly Cell Atlas project found the gene expressed in that cell type. Darker colors mean that more cells of that cell type express the gene:

low

high

Colorless tiles indicate that there is no scRNAseq data for the gene in that cell type.

Colored tiles in ribbon indicate that expression data (RNA and/or protein) has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

Colored tiles in the ribbon indicate the average RNA expression level of the gene at the indicated stages:

low

high

as determined by RNA-seq (RPKM) using whole organism samples modENCODE, Brown et al., 2014. For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

prepupal stage P3

leg | ubiquitous

(Greenberg and Hatini, 2011)

leg joint of tarsal segment

Comment: elevated level

(Greenberg and Hatini, 2011)

Additional Descriptive Data

Expression in stage P3 pupal leg discs is ubiquitous but is elevated in the tarsal joints.

(Greenberg and Hatini, 2011)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 12

organism | ubiquitous

(Yang and Bashaw, 2006)

embryonic stage 12 -- 17

neuron of embryonic/larval central nervous system

• axon

(Yang and Bashaw, 2006)

embryonic stage 16

embryonic/larval tracheal section

(Yang and Bashaw, 2006)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

day 5 of adulthood & male -- day 7 of adulthood & male

(Wasbrough et al., 2010)

Additional Descriptive Data

Sos protein is widely expressed at embryonic stage 12, but has begun to be enriched in developing axons.

(Yang and Bashaw, 2006)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytosol

inferred from direct assay

(Yang and Bashaw, 2006)

located_in extrinsic component of cytoplasmic side of plasma membrane

inferred from direct assay

(Yang and Bashaw, 2006)

located_in rhabdomere microvillus membrane

inferred from direct assay

(Karlovich et al., 1995)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Sos in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Sos

View exonic expression by tissue for Dmel\Sos

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34790/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0001965

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0001965

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0001965

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7793

Flygut - An atlas of the Drosophila adult midgut

FBgn0001965

Images

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 78 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 22 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Sos

Transgenic constructs containing regulatory region of Sos

Aberrations (Deficiencies and Duplications) ( 105 )

Inferred from experimentation ( 105 )

Gene disrupted in

(Iyengar et al., 1999, Woodruff and Ashburner, 1979)

(Gubb et al., 1990, Woodruff and Ashburner, 1979)

(Iyengar et al., 1999, Simon et al., 1991, Ashburner et al., 1982)

(Alexandrova et al., 1996)

(Roote, 1996.8)

(Alexandrova et al., 1996)

(Bonfini et al., 1992)

(Roote, 2000.7.3, Iyengar et al., 1999, Roote, 1995.3.27)

(Roote et al., 1996, Bonfini et al., 1992)

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

(Alexandrova et al., 1996)

(Roote, 1995.3.27)

(Roote, 2000.6.5, Roote, 2000.7.3)

(Roote, 2000.6.5)

(Roote, 2000.6.5)

(Verheyen et al., 1996)

(Ryder, 2004.4.26)

(Ashburner et al., 1982)

(Ashburner et al., 1982)

(Gubb et al., 1990)

(Bonfini et al., 1992)

(Gubb et al., 1985)

(Gubb et al., 1984)

Df(2L)TE35BC-23

(Gubb et al., 1984)

(Roote, 1998.3.4)

(Iyengar et al., 1999)

(Iyengar et al., 1999, Roote, 1995.3.27)

(Roote, 2000.6.5)

(Roote, 1997.2.3, Bonfini et al., 1992)

(Roote, 2000.6.5)

(Alexandrova et al., 1996)

T(Y;2;3)b^88g22

(Roote, 2000.6.5, Roote, 1995.3.27)

(Alexandrova et al., 1996)

Gene not disrupted in

(Gubb et al., 1990, Ashburner et al., 1982)

(Gubb et al., 1990, Ashburner et al., 1982)

(Ashburner et al., 1982)

(Ashburner et al., 1982)

(Ashburner et al., 1982)

(Ashburner et al., 1982)

(Ashburner et al., 1982)

(Ashburner et al., 1982)

(Ashburner et al., 1982)

(Ashburner et al., 1982)

(Ashburner et al., 1982)

(Ashburner et al., 1982)

(Ashburner et al., 1982)

(Ashburner et al., 1982)

(Ashburner et al., 1982)

(Ashburner et al., 1982)

(Ashburner et al., 1982)

(Ashburner et al., 1982)

(Ashburner et al., 1982)

(Ashburner et al., 1982)

Df(2L)b81a2^LA80^R

(Roote, 2000.7.3)

(Roote, 2000.7.3)

(Roote, 2000.7.3)

(Roote, 2000.7.3)

(Woodruff and Ashburner, 1979)

(Ashburner et al., 1982, Woodruff and Ashburner, 1979)

(Ashburner et al., 1982, Woodruff and Ashburner, 1979)

(Ashburner et al., 1982, Woodruff and Ashburner, 1979)

(Ashburner et al., 1982)

(Ashburner et al., 1982, Woodruff and Ashburner, 1979)

(Ashburner et al., 1982, Woodruff and Ashburner, 1979)

(Ashburner et al., 1982)

(Ashburner et al., 1982)

(Ashburner et al., 1982)

(Ashburner et al., 1982)

(Gubb et al., 1990)

(Roote, 1996.8)

(Woodruff and Ashburner, 1979)

(Gubb et al., 1985)

(Gubb et al., 1985)

(Gubb et al., 1985)

(Gubb et al., 1985)

(Gubb et al., 1985)

(Gubb et al., 1985)

(Gubb et al., 1985)

(Gubb et al., 1985)

(Gubb et al., 1985)

(Gubb et al., 1985)

(Gubb et al., 1985)

(Gubb et al., 1985)

(Gubb et al., 1984)

(Gubb et al., 1984)

(Gubb et al., 1984)

(Gubb et al., 1984)

(Gubb et al., 1984)

Df(2L)TE35BC-24

(Gubb et al., 1984)

Df(2L)TE35BC-28

(Gubb et al., 1984)

Df(2L)TE35BC-29

(Gubb et al., 1984)

Df(2L)TE35BC-31

(Gubb et al., 1984)

Df(2L)TE35BC-34

(Gubb et al., 1984)

Df(2L)TE35BC-35

(Gubb et al., 1984)

(Woodruff and Ashburner, 1979)

In(2L)75c^LC158.1^R

(Woodruff and Ashburner, 1979)

(Woodruff and Ashburner, 1979)

(Iyengar et al., 1999)

(Gubb et al., 1985)

In(2LR)b81a2^LDTD43^R

(Roote, 2000.7.3, Bonfini et al., 1992)

(Bonfini et al., 1992)

(Woodruff and Ashburner, 1979)

T(Y;2)A80^DR15^P

(Woodruff and Ashburner, 1979)

T(Y;2)J165^DP58^P

(Woodruff and Ashburner, 1979)

T(Y;2)R15^DJ165^P

(Woodruff and Ashburner, 1979)

(Ashburner et al., 1982)

Gene partially disrupted in

Df(2L)b81a2^LA80^R

(Iyengar et al., 1999)

(Iyengar et al., 1999)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | maternal effect | recessive

lethal | recessive

lethal - all die before end of pupal stage | recessive

lethal - all die during embryonic stage | germline clone | maternal effect | recessive

lethal - all die during embryonic stage | recessive

Sos^x122

lethal - all die during P-stage, with Scer\GAL4^Mef2.PR

Sos^GD1539

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Sos^GD1539

viable, with Scer\GAL4^pnr-MD237

Sos^GD1539

viable, with Scer\GAL4^tin.CΔ4

Sos^GD1539

Sterility

Allele

Sos^KG10074

Other Phenotypes

Allele

abnormal body color, with Scer\GAL4^pnr-MD237

Sos^GD1539

abnormal mitotic cell cycle | cell autonomous | somatic clone

Sos^x122

abnormal neuroanatomy | embryonic stage 17

Sos^e2H

enhancer of variegation | dominant, with In(1)w^m4h

Sos¹⁸⁹

some die during embryonic stage | maternal effect | recessive

some die during embryonic stage | recessive

Sos^x122

some die during pupal stage | recessive

terminal phenotype | germline clone | maternal effect

visible, with Scer\GAL4^pnr-MD237

Sos^GD1539

visible | adult stage, with Scer\GAL4^en-e16E

visible | recessive

visible | somatic clone

Sos^unspecified

Phenotype manifest in

Allele

abdominal 1 lateral pentascolopidial chordotonal organ lch5

Sos^unspecified

abdominal 1 ventral monoscolopidial chordotonal organ vch1

Sos^unspecified

abdominal 2 lateral pentascolopidial chordotonal organ lch5

Sos^unspecified

abdominal 2 ventral monoscolopidial chordotonal organ vch1

Sos^unspecified

abdominal 3 lateral pentascolopidial chordotonal organ lch5

Sos^unspecified

abdominal 3 ventral monoscolopidial chordotonal organ vch1

Sos^unspecified

abdominal 4 lateral pentascolopidial chordotonal organ lch5

Sos^unspecified

abdominal 4 ventral monoscolopidial chordotonal organ vch1

Sos^unspecified

abdominal 5 lateral pentascolopidial chordotonal organ lch5

Sos^unspecified

abdominal 5 ventral monoscolopidial chordotonal organ vch1

Sos^unspecified

abdominal 6 lateral pentascolopidial chordotonal organ lch5

Sos^unspecified

abdominal 6 ventral monoscolopidial chordotonal organ vch1

Sos^unspecified

abdominal 7 lateral pentascolopidial chordotonal organ lch5

Sos^unspecified

abdominal 7 ventral monoscolopidial chordotonal organ vch1

Sos^unspecified

chaeta | increased number, with Scer\GAL4^pnr-MD237

Sos^GD1539

commissure | embryonic stage 17

Sos^e2H

Sos^e49

dorsal air sac primordium | somatic clone

embryo | germline clone | maternal effect

eye disc | cell autonomous | somatic clone

Sos^x122

glial cell, with Scer\GAL4^repo, Scer\GAL80^ts.αTub84B

Sos^GD1539

larval longitudinal connective

larval longitudinal connective | embryonic stage 17

Sos^e2H

mesothoracic tergum, with Scer\GAL4^pnr-MD237

Sos^GD1539

ommatidium | somatic clone

Sos^34Ea-6

Sos^e49

photoreceptor cell R1

photoreceptor cell R2

photoreceptor cell R3

photoreceptor cell R4

photoreceptor cell R5

photoreceptor cell R6

photoreceptor cell R7

photoreceptor cell R8

symmetrical commissure

Sos^x122

trichogen cell, with Scer\GAL4^pnr-MD237

Sos^GD1539

vesicle, with Scer\GAL4^repo, Scer\GAL80^ts.αTub84B

Sos^GD1539

Sos^e49

wing, with Scer\GAL4^en-e16E

wing vein, with Scer\GAL4^en-e16E

wing vein | ectopic

wing vein L4 | somatic clone

Sos^unspecified

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (17)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

14 of 15

Yes

Yes

12 of 15

No

Yes

1

2 of 15

No

No

2 of 15

No

Yes

2 of 15

No

Yes

2 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

2

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (18)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

14 of 15

Yes

Yes

11 of 15

No

Yes

2 of 15

No

No

2 of 15

No

Yes

2 of 15

No

Yes

Mmus\4933421I07Rik

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Rattus norvegicus (Norway rat) (12)

11 of 13

Yes

Yes

10 of 13

No

Yes

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

1 of 13

No

No

Xenopus tropicalis (Western clawed frog) (11)

8 of 12

Yes

Yes

7 of 12

No

Yes

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

1 of 12

No

No

Danio rerio (Zebrafish) (11)

10 of 15

Yes

Yes

7 of 15

No

Yes

2 of 15

No

No

2 of 15

No

No

2 of 15

No

Yes

Drer\si:ch211-234p18.3

2 of 15

No

Yes

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

1 of 15

No

No

Caenorhabditis elegans (Nematode, roundworm) (4)

15 of 15

Yes

Yes

2 of 15

No

No

1 of 15

No

No

1 of 15

No

Yes

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (4)

7 of 15

Yes

Yes

3 of 15

No

Yes

2 of 15

No

No

1 of 15

No

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

5 of 12

Yes

Yes

4 of 12

No

Yes

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (8)

Gene Symbol

Score

Source

Alignment

4 of 10

3 of 10

3 of 10

2 of 10

2 of 10

2 of 10

2 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 3 )

Human Ortholog

Disease

Evidence

References

SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1

model of Noonan syndrome 4

IEA

(FlyBase, 2019-)

model of gingival fibromatosis

IEA

(FlyBase, 2019-)

SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2

model of Noonan syndrome 9

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

ameliorates autosomal dominant cerebellar ataxia

modeled by Hsap\ATXN1^82Q.UAS

(Park et al., 2013)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1

14 of 15

SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2

12 of 15

NOONAN SYNDROME 9; NS9

Noonan syndrome 9

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

two hybrid, anti tag coimmunoprecipitation, anti tag western blot, pull down, western blot

(Yang and Bashaw, 2006)

pull down, western blot, far western blotting, anti tag coimmunoprecipitation, peptide massfingerprinting, lambda phage display, autoradiography

(Friedman et al., 2011, Le and Simon, 1998, Olivier et al., 1993)

anti tag coimmunoprecipitation, anti tag western blot, western blot

(Yang and Bashaw, 2006)

anti tag coimmunoprecipitation, peptide massfingerprinting

(Friedman et al., 2011)

RNA-protein

Physical Interaction

Assay

References

rna three hybrid

(Kim et al., 2012)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Rogge et al., 1995)

enhanceable

(Kolodkin et al., 1994)

enhanceable

(Fritz and VanBerkum, 2002)

enhanceable

(Taguchi et al., 2000)

enhanceable

(Zhang and Lu, 2000)

enhanceable

(Dong et al., 1999)

enhanceable

(Dong et al., 1999)

enhanceable

(Lu et al., 2014)

enhanceable

(Fritz and VanBerkum, 2002)

enhanceable

(Fritz and VanBerkum, 2002)

suppressible

(Fritz and VanBerkum, 2002)

enhanceable

(Pazman et al., 2000)

suppressible

(Kolodkin et al., 1994)

enhanceable

(Kolodkin et al., 1994)

suppressible

(Kolodkin et al., 1994)

suppressible

(Lu and Li, 1999)

suppressible

(Dong et al., 1999)

enhanceable

(Malartre et al., 2010)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Chen et al., 1999)

enhanceable

(Rebay et al., 2000, Chen et al., 1999)

suppressible

(Hayashi et al., 1998)

enhanceable

(Hayashi et al., 1998)

suppressible

(Lu et al., 2014)

enhanceable

(Firth et al., 2000)

suppressible

(Oishi et al., 2009, Oishi et al., 2006)

suppressible

(Lu et al., 2014)

suppressible

(Dong et al., 1999)

suppressible

(Verheyen et al., 1996, Doyle and Bishop, 1993)

enhanceable

(Ruan et al., 2016)

suppressible

(Fritz and VanBerkum, 2000)

Khc::Ggal\MLCK|robo1

suppressible

(Fritz and VanBerkum, 2000)

suppressible

(Reich and Shilo, 2002)

enhanceable

(Therrien et al., 2000)

enhanceable

(Lu et al., 2014)

enhanceable

(Verheyen et al., 1996)

suppressible

(Williams et al., 2001)

suppressible

(Lu et al., 2014)

enhanceable

(Therrien et al., 2000)

enhanceable

(Rebay et al., 2000)

suppressible

(Rebay et al., 2000)

suppressible

(Maixner et al., 1998)

suppressible

(Read et al., 2005)

suppressible

(Freeman, 1994)

suppressible

(Fritz and VanBerkum, 2000)

suppressible

(Dong et al., 1999)

suppressible

(Pazman et al., 2000, Kolodkin et al., 1994, Bonfini et al., 1992, Rogge et al., 1991)

enhanceable

(Murillo-Maldonado et al., 2011)

suppressible

(Murillo-Maldonado et al., 2011)

enhanceable

(Fritz and VanBerkum, 2000)

suppressible

(Rawlings et al., 2004)

suppressible

(Zhang et al., 1999, Takahashi et al., 1996)

suppressible

(Begemann et al., 1995, Kramer et al., 1995)

enhanceable

(Begemann et al., 1995, Kramer et al., 1995)

suppressible

(Li and Li, 2003, Doyle and Bishop, 1993)

enhanceable

(Malartre et al., 2010)

External Data

Subunit Structure (UniProtKB)

May form a complex with sevenless and DRK.

(UniProt, P26675 )

Linkouts

BioGRID - A database of protein and genetic interactions.

60823

DroID - A comprehensive database of gene and protein interactions.

FBgn0001965

MIST (genetic) - An integrated Molecular Interaction Database

Sos

MIST (protein-protein) - An integrated Molecular Interaction Database

Sos

Pathways

Signaling Pathways (FlyBase)

Torso Signaling Pathway Core Components -: The formation of Drosophila embryonic termini is controlled by the localized activation of Torso (tor) receptor tyrosine kinase. The Torso signaling pathway acts via the canonical Ras/Raf/MAP kinase cascade. (Adapted from FBrf0157176.)
Sevenless Signaling Pathway Core Components -: The specification of the R7 photoreceptor cell in each ommatidium of the developing Drosophila eye is dependent on activation of Sevenless receptor tyrosine kinase, which acts via the canonical Ras/Raf/MAP kinase cascade to promote the expression of lz and pros. sev, expressed in presumptive R7 cells, is activated by binding to Bride of Sevenless (boss), a seven-transmembrane protein expressed in R8 cells. (Adapted from FBrf0127283 and FBrf0221727).
EGFR Signaling Pathway Core Components -: The Epidermal Growth Factor Receptor (EGFR) signaling pathway is used multiple times during development (FBrf0190321). It is activated by the binding of a secreted ligand to the receptor tyrosine kinase Egfr and acts via the canonical Ras/Raf/MAP kinase (ERK) cascade. (Adapted from FBrf0190321 and FBrf0221727).
FGFR Signaling Pathway Core Components -: Fibroblast Growth Factor Receptor (FGFR) signaling pathway is initiated by the binding of secreted FGFs - bnl or ths/pyr to receptor tyrosine kinases btl or htl, respectively, to initiate signaling primarily via the canonical Ras/Raf/MAP kinase (ERK) cascade. (Adapted from FBrf0221038).
Pvr Signaling Pathway Core Components -: PDGF/VEGF (Platelet-Derived Growth Factor/Vascular Endothelial Growth Factor)-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

2L

Recombination map

2-49

Cytogenetic map

Sequence location

2L:13,813,816..13,819,824 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

34D1-34D1

Limits computationally determined from genome sequence between P{lacW}CG7364^k07245 and P{lacW}Sos^k05224&P{lacW}RpII33^k05605

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

34D3-34D8

(determined by in situ hybridisation) 34D4--6 (determined by in situ hybridisation) 34D5--6 (determined by in situ hybridisation)

(Ashburner et al., 1999)

34D4-34D6

(determined by in situ hybridisation)

(Spradling et al., 1999)

34D-34D

(Gibson et al., 1999)

34D4-34D6

34D5--6

(BDGP Project Members, 1994-1999)

34D3-34D8

(determined by in situ hybridisation)

(Dorn et al., 1993)

Experimentally Determined Recombination Data

Location

2-49

(FlyBase, 2016)

2-45.1

(Comeron et al., 2012)

2-

(Dorn et al., 1993)

2-48

(Simon et al., 1991)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (20)

Aberrations including deletions of this gene Aberrations including duplications of this gene

43400

w^*; P{GSV1}Sos^EP-1008

16503

y¹; P{SUPor-P}Sos^KG10074

31174

y¹ v¹; P{TRiP.JF01680}attP2

31275

y¹ v¹; P{TRiP.JF01216}attP2

31597

y¹ v¹; P{TRiP.JF01186}attP2

2240

b¹ Sos^34Ea-6 Adhⁿ⁴/CyO

10566

y¹ w^67c23; P{lacW}Sos^k05224/CyO

106751

b¹ Sos^34Ea-6 Adhⁿ⁴/CyO

102411

y¹ w^67c23 ; P{lacW}Sos^k05705 / CyO

v106925

P{KK102390}VIE-260B

v42848

w¹¹¹⁸; P{GD1539}v42848

v318202

PBac{fTRG00714.sfGFP-TVPTBF}VK00033

More stocks available...

Genomic Clones (19)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (57)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

FI22903

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0001965

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0001965

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

34790

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Simon et al., 1993)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Sos CG7793

(Guan, 1999.11)

Source for database merge of

Source for merge of: Sos E(var)189

(Roote, 1997.6.6)

Additional comments

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 cells: change from round to spindle-shaped, with the formation of F-actin puncta and microtubule extensions. S2R+ cells are unaffected.

(Kiger et al., 2003)

6 alleles of Sos been recovered in a screen for mutations with mutant phenotypes in clones in the wing.

(Vegh and Basler, 2003)

The Sos signaling pathway is required to prevent certain axons crossing the midline during the development of the central nervous system.

(Fritz and VanBerkum, 2000)

Identification: One of a collection of genes identified with defective larval growth that extend larval life. Not studied further due to apparent lack of association of mutant phenotype with insertion of P-element present in the mutant chromosome.

(Galloni and Edgar, 1999)

Shows no genetic interaction with sdk.

(Nguyen et al., 1997)

The effect of binding a Pro-rich peptide derived from Sos on the equilibrium between the folded and unfolded state of drk SH3 domain is investigated.

(Zhang and Forman-Kay, 1997)

Activated mutations of Sos suppress the P{sevhs-csw^CS} phenotype and inactivated mutations enhance the mutant phenotype.

(Herbst et al., 1996)

Studies of interaction between argos and members of the Ras/MAPK pathway demonstrate the argos gene product is a negative regulator of signal transduction that acts upstream of the Ras/MAPK cascade.

(Sawamoto et al., 1996)

Loss of function alleles of Sos are enhancers of the csw^{Esev1A-3EC.sev} and csw^{Esev1A-eOP.sev} phenotype.

(Carroll et al., 1995)

In vivo structure-function analysis revealed that the amino terminus of the Sos product is essential for its function. Membrane localization of Sos protein is independent of drk function. A drk-independent interaction between Sos and sev has been proposed that is likely mediated by the pleckstrin homology domain within the amino terminus of Sos.

(Karlovich et al., 1995)

The role of the N and C terminal regions of Sos are studied in mammalian cells to directly measure the effect on p21^ras loading with GTP. Results demonstrate a functional role for pleckstrin and Dbl domains within the Sos protein.

(McCollam et al., 1995)

A high affinity binding site for the drk SH3 domain maps to the Sos product tail. The N-terminal drk SH3 domain is primarily responsible for binding to the tail of the Sos product in vitro, and for signalling to the Ras85D product in vivo.

(Raabe et al., 1995)

Experiments on Ras activation in signal transduction by human insulin receptor in COS cells found heterologously expressed Sos gene product in a complex with insulin receptor and GRB2 or p85.

(Baltensperger et al., 1993)

Dosage-dependent genetic interaction between S and sev, Ras85D and Sos (involved in receptor tyrosine kinase signalling) supports a role for S in cell-cell signalling.

(Heberlein et al., 1993)

Heat shock induced expression, embryonic injection and female mosaic analysis demonstrates that Ras85D and its positive regulator Sos are involved in the tor signalling pathway.

(Lu et al., 1993)

In vitro, drk binds the C terminal tail of the Sos product through the drk SH3 domain, thereby linking receptor tyrosine kinases to Ras activation.

(Olivier et al., 1993)

Sos has been cloned and sequenced.

(Bonfini et al., 1992)

The Sos gene product is common to the sev as well as the Egfr receptor tyrosine kinase pathway but the interaction of Sos with Egfr is limited to the developing eye. Suppression of sev by Sos is allele specific.

(Rogge et al., 1991)

Sos is required for photoreceptor development, acts in R7 and is a suppressor of the Egfr phenotype to restore the eye to a nearly normal appearance.

(Simon et al., 1991)

Recessive lethal or semi-lethal; heteroallelic or hemizygous escapers have small rough eyes; heterozygotes between two weak alleles viable with rough eyes.

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 138 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34790

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P26675

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P26675

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P26675

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0001965

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34790/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0001965

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Sos_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0001965

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0001965

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG7793

Flygut - An atlas of the Drosophila adult midgut

FBgn0001965

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

34790

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC015124

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG7793

MARRVEL_MODEL - MARRVEL (model organism gene)

34790

modMine - A data warehouse for the modENCODE project

FBgn0001965

PDB - An information portal to biological macromolecular structures

1AZE

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

P26675

Linkouts

BioGRID - A database of protein and genetic interactions.

60823

DroID - A comprehensive database of gene and protein interactions.

FBgn0001965

DRSC - Results frm RNAi screens

FBgn0001965

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0001965

FlyMine - An integrated database for Drosophila genomics

FBgn0001965

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

MIST (genetic) - An integrated Molecular Interaction Database

Sos

MIST (protein-protein) - An integrated Molecular Interaction Database

Sos

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (31)

Reported As

Symbol Synonym

2.3

(Gibson et al., 1999)

34Ea

(Kumar and Moses, 2000)

BG:DS00941.4

(Ashburner et al., 1999, Ashburner et al., 1999.10.12)

CG7793

(Balakrishnan et al., 2015, Hosono et al., 2015, Greenberg and Hatini, 2011, Ni et al., 2011.7.19, Keleman et al., 2009.8.5, van Dam et al., 2009, Ni et al., 2008, Molnar et al., 2006)

E(sev)2A

(Kumar and Moses, 2000, Yamamoto, 1993, Simon et al., 1991)

E(var)189

EC2-5

(Baril et al., 2014)

EK2-8

(Therrien et al., 2000)

EY2-3

(Rebay et al., 2000, Chen et al., 1999)

SOS

(Davidson and Wood, 2020, Lusk et al., 2017, Winfree et al., 2017, Freeman, 2015, Lu et al., 2014, Slack et al., 2010, van Dam et al., 2009, Carroll et al., 1995, Marshall, 1994)

SoS

(Hayashi and Ogura, 2020)

Sos

(Bilder et al., 2021, DeAngelis et al., 2021, Yoong et al., 2020, Ray et al., 2019, Inoue et al., 2018, Ogura et al., 2018, Ashton-Beaucage and Therrien, 2017, Chabu et al., 2017, Li et al., 2017, Nakamura et al., 2017, Transgenic RNAi Project members, 2017-, Zhu et al., 2017, Malartre, 2016, Sarov et al., 2016, Chance and Bashaw, 2015, Vedanayagam and Garrigan, 2015, Baril et al., 2014, Macagno et al., 2014, Bergwitz et al., 2013, Carter, 2013, de Celis et al., 2013.9.11, Mbodj et al., 2013, Muha and Müller, 2013, Park et al., 2013, Sopko and Perrimon, 2013, Izutsu et al., 2012, Alic et al., 2011, Diez et al., 2011, Friedman et al., 2011, Friedman et al., 2011, Murillo-Maldonado et al., 2011, Ragab et al., 2011, Coleman et al., 2010, Mourikis et al., 2010, Salzer et al., 2010, Wasbrough et al., 2010, Oishi et al., 2009, Sims et al., 2009, Yan et al., 2009, Zhou et al., 2008, Bakal et al., 2007, Zhang et al., 2007, Friedman and Perrimon, 2006, Molnar et al., 2006, Yang and Bashaw, 2006, Firth and Baker, 2005, Harrison et al., 2005, Rawlings et al., 2004, Silver et al., 2004, Voas and Rebay, 2004, Dawes-Hoang and Wieschaus, 2001, Gim et al., 2001, Pazman et al., 2000, Biggs et al., 1994)

Sos1

(McCormick, 1993)

Su(tor)2-2

(Kumar and Moses, 2000, Doyle and Bishop, 1993)

br24

(Gubb et al., 1985)

br25

(Kumar and Moses, 2000)

dSos

(Swevers et al., 2018, Wennstrom and Downward, 1999, McCollam et al., 1995, Cherniack et al., 1994)

dme-SOS

(Baxevanis et al., 1995)

l(2)34Ea

(Ashburner et al., 1999, The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Alexandrova et al., 1996, Gubb et al., 1990)

l(2)Sos

l(2)br24

(Kumar and Moses, 2000, The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Gubb et al., 1984, Ashburner et al., 1982, Woodruff and Ashburner, 1979)

l(2)br25

(Woodruff and Ashburner, 1979)

l(2)k05224

(Galloni and Edgar, 1999, Chen et al., 1998)

l(2)k06321

(Chen et al., 1998)

Name Synonyms

Son of sevenless

(Ashton-Beaucage and Therrien, 2017, Malartre, 2016, Muha and Müller, 2013, Murillo-Maldonado et al., 2011, Salzer et al., 2010, Harrison et al., 2005, Rawlings et al., 2004)

Son-of-sevenless

(Gim et al., 2001)

lethal 24 in the black-reduced region

(Woodruff and Ashburner, 1979)

lethal 25 in the black-reduced region

(Woodruff and Ashburner, 1979)

son of sevenless

(Lu et al., 2014, Ni et al., 2009, Ni et al., 2008, Oishi et al., 2006)

son-of-sevenless

(Hsouna and VanBerkum, 2008)

Secondary FlyBase IDs

FBgn0013235
FBgn0026802

Datasets (1)

Study focus (1)

Experimental Role

Project

Project Type

Title

bait_protein

RTK-Ras-ERK_interaction_map

interactome

Interaction map generated by purification of receptor tyrosine kinase pathway factors, with identification of copurifying proteins by mass spectrometry.

Study result (0)

Result

Result Type

Title

References (324)