General Information
Symbol
Dmel\Sos
Species
D. melanogaster
Name
Son of sevenless
Annotation Symbol
CG7793
Feature Type
FlyBase ID
FBgn0001965
Gene Model Status
Stock Availability
Gene Snapshot
In progress.Contributions welcome.
Also Known As
l(2)br24, l(2)34Ea, dSos, E(sev)2A, EY2-3
Genomic Location
Cytogenetic map
Sequence location
2L:13,813,816..13,819,824 [+]
Recombination map
2-49
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
GO Summary Ribbons
Families, Domains and Molecular Function
Protein Family (UniProt, Sequence Similarities)
-
Molecular Function (see GO section for details)
Summaries
Gene Group Membership
RAS GUANINE NUCLEOTIDE EXCHANGE FACTORS -
RasGEFs are Guanine Nucleotide Exchange Factors (GEFs) for Ras family GTPases. The RasGEFs are characterized by a CDC25 homology domain. (Adapted from FBrf0220530).
RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS -
RhoGEFs are Guanine Nucleotide Exchange Factors (GEFs) for Rho family GTPases. They include Dbl-homology domain-containing proteins (the largest family of RhoGEFs) and CZH2 domain/Dock family GEFs. (Adapted from FBrf0190957).
Torso Signaling Pathway Core Components -
Formation of the Drosophila embryonic termini is controlled by the localized activation of the receptor tyrosine kinase, Torso (tor). The Torso signaling pathway acts via the canonical Ras/Raf/MAP kinase cascade. (Adapted from FBrf0157176).
Sevenless Signaling Pathway Core Components -
The specification of the R7 photoreceptor cell in each ommatidium of the developing Drosophila eye is dependent on activation of Sevenless receptor tyrosine kinase, which acts via the canonical Ras/Raf/MAP kinase cascade to promote the expression of lz and pros. sev, expressed in presumptive R7 cells, is activated by binding to Bride of Sevenless (boss), a seven-transmembrane protein expressed in R8 cells. (Adapted from FBrf0127283 and FBrf0221727).
Epidermal Growth Factor Receptor Signaling Pathway Core Components -
The Epidermal Growth Factor Receptor (EGFR) signaling pathway is used multiple times during development (FBrf0190321). It is activated by the binding of a secreted ligand to the receptor tyrosine kinase Egfr and acts via the canonical Ras/Raf/MAP kinase (ERK) cascade. (Adapted from FBrf0190321 and FBrf0221727).
Fibroblast Growth Factor Receptor Signaling Pathway Core Components -
Fibroblast Growth Factor Receptor (FGFR) signaling pathway is initiated by the binding of secreted FGFs - bnl or ths/pyr to receptor tyrosine kinases btl or htl, respectively, to initiate signaling primarily via the canonical Ras/Raf/MAP kinase (ERK) cascade. (Adapted from FBrf0221038).
Platelet-Derived Growth Factor-Vascular Endothelial Growth Factor Receptor-Related Signaling Pathway Core Components -
PDGF/VEGF-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
UniProt Contributed Function Data
Promotes the exchange of Ras-bound GDP by GTP. Functions in signaling pathways initiated by the sevenless and epidermal growth factor receptor tyrosine kinases; implies a role for the ras pathway in neuronal development.
(UniProt, P26675)
Phenotypic Description from the Red Book (Lindsley and Zimm 1992)
l(2)34Ea
Recessive lethal or semilethal; heteroallelic or hemizygous escapers have small rough eyes; heterozygotes between two weak alleles viable with rough eyes.
Interactive Fly
a dual specificity GEF that regulates both Ras and Rho family GTPases - integrates signals that affect gene expression and cytoskeletal reorganization - Slit-dependent endocytic trafficking of the Robo receptor is required for Son of Sevenless recruitment and midline axon repulsion
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Sos or the JBrowse view of Dmel\Sos for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.45
Gene model reviewed during 6.02
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0080541
5635
1596
Additional Transcript Data and Comments
Reported size (kB)
5.5 (longest cDNA)
6.0 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0080118
177.9
1596
7.42
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)
May form a complex with sevenless and DRK.
(UniProt, P26675)
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sos using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (26 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from electronic annotation with InterPro:IPR007125
(assigned by InterPro )
inferred from electronic annotation with InterPro:IPR009072
(assigned by InterPro )
Biological Process (17 terms)
Terms Based on Experimental Evidence (16 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with FLYBASE:tor; FB:FBgn0003733
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
Cellular Component (4 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
inferred from electronic annotation with InterPro:IPR007125
(assigned by InterPro )
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Sos protein is widely expressed at embryonic stage 12, but has begun to be enriched in developing axons.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Sos in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 78 )
For All Classical and Insertion Alleles Show
 
Allele of Sos
Class
Mutagen
Associated Insertion
Stocks
Known lesion
    0
    Yes
      0
      Yes
        0
        Yes
          0
          --
            0
            --
              0
              --
                0
                --
                  0
                  --
                    0
                    --
                    Other relevant insertions
                    miscellaneous insertions
                    Name
                    Expression Data
                    Transgenic Constructs ( 22 )
                    For All Alleles Carried on Transgenic Constructs Show
                    Transgenic constructs containing/affecting coding region of Sos
                    Allele of Sos
                    Mutagen
                    Associated Transgenic Construct
                    Stocks
                    Transgenic constructs containing regulatory region of Sos
                    Deletions and Duplications ( 105 )
                    Not disrupted in
                    Phenotypes
                    For more details about a specific phenotype click on the relevant allele symbol.
                    Lethality
                    Allele
                    Sterility
                    Allele
                    Other Phenotypes
                    Allele
                    Phenotype manifest in
                    Allele
                    Orthologs
                    Human Orthologs (via DIOPT v7.1)
                    Homo sapiens (Human) (8)
                    Species\Gene Symbol
                    Score
                    Best Score
                    Best Reverse Score
                    Alignment
                    Complementation?
                    Transgene?
                    15 of 15
                    Yes
                    Yes
                    13 of 15
                    No
                    Yes
                    1 of 15
                    No
                    No
                    1 of 15
                    No
                    No
                    1 of 15
                    No
                    No
                    1 of 15
                    No
                    Yes
                    1 of 15
                    No
                    Yes
                    1 of 15
                    No
                    Yes
                    Model Organism Orthologs (via DIOPT v7.1)
                    Mus musculus (laboratory mouse) (10)
                    Species\Gene Symbol
                    Score
                    Best Score
                    Best Reverse Score
                    Alignment
                    Complementation?
                    Transgene?
                    14 of 15
                    Yes
                    Yes
                    13 of 15
                    No
                    Yes
                    2 of 15
                    No
                    No
                    1 of 15
                    No
                    No
                    1 of 15
                    No
                    No
                    1 of 15
                    No
                    No
                    1 of 15
                    No
                    No
                    1 of 15
                    No
                    Yes
                    1 of 15
                    No
                    Yes
                    1 of 15
                    No
                    Yes
                    Rattus norvegicus (Norway rat) (6)
                    12 of 13
                    Yes
                    Yes
                    10 of 13
                    No
                    Yes
                    1 of 13
                    No
                    No
                    1 of 13
                    No
                    No
                    1 of 13
                    No
                    Yes
                    1 of 13
                    No
                    Yes
                    Xenopus tropicalis (Western clawed frog) (3)
                    8 of 12
                    Yes
                    Yes
                    7 of 12
                    No
                    Yes
                    1 of 12
                    No
                    No
                    Danio rerio (Zebrafish) (8)
                    10 of 15
                    Yes
                    Yes
                    8 of 15
                    No
                    Yes
                    2 of 15
                    No
                    No
                    1 of 15
                    No
                    Yes
                    1 of 15
                    No
                    No
                    1 of 15
                    No
                    Yes
                    1 of 15
                    No
                    Yes
                    Caenorhabditis elegans (Nematode, roundworm) (3)
                    14 of 15
                    Yes
                    Yes
                    1 of 15
                    No
                    No
                    1 of 15
                    No
                    No
                    Arabidopsis thaliana (thale-cress) (0)
                    No orthologs reported.
                    Saccharomyces cerevisiae (Brewer's yeast) (4)
                    7 of 15
                    Yes
                    Yes
                    2 of 15
                    No
                    Yes
                    2 of 15
                    No
                    Yes
                    1 of 15
                    No
                    Yes
                    Schizosaccharomyces pombe (Fission yeast) (2)
                    3 of 12
                    Yes
                    Yes
                    2 of 12
                    No
                    No
                    Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091900TK )
                    Organism
                    Common Name
                    Gene
                    AAA Syntenic Ortholog
                    Multiple Dmel Genes in this Orthologous Group
                    Drosophila melanogaster
                    fruit fly
                    Drosophila suzukii
                    Spotted wing Drosophila
                    Drosophila simulans
                    Drosophila sechellia
                    Drosophila erecta
                    Drosophila yakuba
                    Drosophila ananassae
                    Drosophila pseudoobscura pseudoobscura
                    Drosophila persimilis
                    Drosophila willistoni
                    Drosophila virilis
                    Drosophila mojavensis
                    Drosophila grimshawi
                    Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500MO )
                    Organism
                    Common Name
                    Gene
                    Multiple Dmel Genes in this Orthologous Group
                    Musca domestica
                    House fly
                    Musca domestica
                    House fly
                    Musca domestica
                    House fly
                    Glossina morsitans
                    Tsetse fly
                    Lucilia cuprina
                    Australian sheep blowfly
                    Mayetiola destructor
                    Hessian fly
                    Aedes aegypti
                    Yellow fever mosquito
                    Anopheles darlingi
                    American malaria mosquito
                    Anopheles gambiae
                    Malaria mosquito
                    Culex quinquefasciatus
                    Southern house mosquito
                    Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00TR )
                    Organism
                    Common Name
                    Gene
                    Multiple Dmel Genes in this Orthologous Group
                    Bombyx mori
                    Silkmoth
                    Danaus plexippus
                    Monarch butterfly
                    Heliconius melpomene
                    Postman butterfly
                    Apis florea
                    Little honeybee
                    Apis mellifera
                    Western honey bee
                    Bombus impatiens
                    Common eastern bumble bee
                    Bombus terrestris
                    Buff-tailed bumblebee
                    Linepithema humile
                    Argentine ant
                    Megachile rotundata
                    Alfalfa leafcutting bee
                    Nasonia vitripennis
                    Parasitic wasp
                    Dendroctonus ponderosae
                    Mountain pine beetle
                    Tribolium castaneum
                    Red flour beetle
                    Pediculus humanus
                    Human body louse
                    Rhodnius prolixus
                    Kissing bug
                    Cimex lectularius
                    Bed bug
                    Acyrthosiphon pisum
                    Pea aphid
                    Acyrthosiphon pisum
                    Pea aphid
                    Zootermopsis nevadensis
                    Nevada dampwood termite
                    Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00JJ )
                    Organism
                    Common Name
                    Gene
                    Multiple Dmel Genes in this Orthologous Group
                    Strigamia maritima
                    European centipede
                    Ixodes scapularis
                    Black-legged tick
                    Stegodyphus mimosarum
                    African social velvet spider
                    Tetranychus urticae
                    Two-spotted spider mite
                    Daphnia pulex
                    Water flea
                    Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G04UL )
                    Organism
                    Common Name
                    Gene
                    Multiple Dmel Genes in this Orthologous Group
                    Strongylocentrotus purpuratus
                    Purple sea urchin
                    Ciona intestinalis
                    Vase tunicate
                    Ciona intestinalis
                    Vase tunicate
                    Gallus gallus
                    Domestic chicken
                    Gallus gallus
                    Domestic chicken
                    Human Disease Model Data
                    FlyBase Human Disease Model Reports
                      Alleles Reported to Model Human Disease (Disease Ontology)
                      Download
                      Models ( 0 )
                      Allele
                      Disease
                      Evidence
                      References
                      Interactions ( 1 )
                      Allele
                      Disease
                      Interaction
                      References
                      Comments ( 0 )
                       
                      Human Orthologs (via DIOPT v7.1)
                      Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
                      Functional Complementation Data
                      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                      Interactions
                      Summary of Physical Interactions
                      Summary of Genetic Interactions
                      esyN Network Diagram
                      esyN Network Key:
                      Suppression
                      Enhancement

                      Please look at the allele data for full details of the genetic interactions
                      Starting gene(s)
                      Interaction type
                      Interacting gene(s)
                      Reference
                      Starting gene(s)
                      Interaction type
                      Interacting gene(s)
                      Reference
                      suppressible
                      suppressible
                      External Data
                      Subunit Structure (UniProtKB)
                      May form a complex with sevenless and DRK.
                      (UniProt, P26675 )
                      Linkouts
                      BioGRID - A database of protein and genetic interactions.
                      DroID - A comprehensive database of gene and protein interactions.
                      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                      Pathways
                      Gene Group - Pathway Membership (FlyBase)
                      Torso Signaling Pathway Core Components -
                      Formation of the Drosophila embryonic termini is controlled by the localized activation of the receptor tyrosine kinase, Torso (tor). The Torso signaling pathway acts via the canonical Ras/Raf/MAP kinase cascade. (Adapted from FBrf0157176).
                      Sevenless Signaling Pathway Core Components -
                      The specification of the R7 photoreceptor cell in each ommatidium of the developing Drosophila eye is dependent on activation of Sevenless receptor tyrosine kinase, which acts via the canonical Ras/Raf/MAP kinase cascade to promote the expression of lz and pros. sev, expressed in presumptive R7 cells, is activated by binding to Bride of Sevenless (boss), a seven-transmembrane protein expressed in R8 cells. (Adapted from FBrf0127283 and FBrf0221727).
                      Epidermal Growth Factor Receptor Signaling Pathway Core Components -
                      The Epidermal Growth Factor Receptor (EGFR) signaling pathway is used multiple times during development (FBrf0190321). It is activated by the binding of a secreted ligand to the receptor tyrosine kinase Egfr and acts via the canonical Ras/Raf/MAP kinase (ERK) cascade. (Adapted from FBrf0190321 and FBrf0221727).
                      Fibroblast Growth Factor Receptor Signaling Pathway Core Components -
                      Fibroblast Growth Factor Receptor (FGFR) signaling pathway is initiated by the binding of secreted FGFs - bnl or ths/pyr to receptor tyrosine kinases btl or htl, respectively, to initiate signaling primarily via the canonical Ras/Raf/MAP kinase (ERK) cascade. (Adapted from FBrf0221038).
                      Platelet-Derived Growth Factor-Vascular Endothelial Growth Factor Receptor-Related Signaling Pathway Core Components -
                      PDGF/VEGF-receptor related (Pvr) encodes a receptor tyrosine kinase activated by the binding of PDGF- and VEGF-related factors (Pvf1,Pvf2 or Pvf3). Pvr has been shown to activate the canonical Ras/Raf/MAP kinase (ERK) cascade, the PI3K kinase pathway, TORC1 (FBrf0222697), Rho family small GTPases (FBrf0221764, FBrf0180198) and the JNK cascade (FBrf0180198), in a context-dependent manner. (Adapted from FBrf0222697 and FBrf0221727).
                      External Data
                      Genomic Location and Detailed Mapping Data
                      Chromosome (arm)
                      2L
                      Recombination map
                      2-49
                      Cytogenetic map
                      Sequence location
                      2L:13,813,816..13,819,824 [+]
                      FlyBase Computed Cytological Location
                      Cytogenetic map
                      Evidence for location
                      34D1-34D1
                      Limits computationally determined from genome sequence between P{lacW}CG7364k07245 and P{lacW}Sosk05224&P{lacW}RpII33k05605
                      Experimentally Determined Cytological Location
                      Cytogenetic map
                      Notes
                      References
                      34D3-34D8
                      (determined by in situ hybridisation) 34D4--6 (determined by in situ hybridisation) 34D5--6 (determined by in situ hybridisation)
                      34D4-34D6
                      (determined by in situ hybridisation)
                      34D3-34D8
                      (determined by in situ hybridisation)
                      Experimentally Determined Recombination Data
                      Left of (cM)
                      Right of (cM)
                      Notes
                      Stocks and Reagents
                      Stocks (22)
                      Genomic Clones (19)
                      cDNA Clones (57)
                       

                      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                      cDNA clones, fully sequences
                      BDGP DGC clones
                      Other clones
                      Drosophila Genomics Resource Center cDNA clones

                      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                      cDNA Clones, End Sequenced (ESTs)
                      RNAi and Array Information
                      Linkouts
                      DRSC - Results frm RNAi screens
                      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                      Antibody Information
                      Laboratory Generated Antibodies
                       
                      polyclonal
                      Commercially Available Antibodies
                       
                      Other Information
                      Relationship to Other Genes
                      Source for database identify of
                      Source for identity of: Sos CG7793
                      Source for database merge of
                      Source for merge of: Sos E(var)189
                      Additional comments
                      Other Comments
                      dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
                      RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 cells: change from round to spindle-shaped, with the formation of F-actin puncta and microtubule extensions. S2R+ cells are unaffected.
                      6 alleles of Sos been recovered in a screen for mutations with mutant phenotypes in clones in the wing.
                      The Sos signaling pathway is required to prevent certain axons crossing the midline during the development of the central nervous system.
                      Identification: One of a collection of genes identified with defective larval growth that extend larval life. Not studied further due to apparent lack of association of mutant phenotype with insertion of P-element present in the mutant chromosome.
                      Shows no genetic interaction with sdk.
                      The effect of binding a Pro-rich peptide derived from Sos on the equilibrium between the folded and unfolded state of drk SH3 domain is investigated.
                      Activated mutations of Sos suppress the P{sevhs-cswCS} phenotype and inactivated mutations enhance the mutant phenotype.
                      Studies of interaction between argos and members of the Ras/MAPK pathway demonstrate the argos gene product is a negative regulator of signal transduction that acts upstream of the Ras/MAPK cascade.
                      Loss of function alleles of Sos are enhancers of the cswEsev1A-3EC.sev and cswEsev1A-eOP.sev phenotype.
                      In vivo structure-function analysis revealed that the amino terminus of the Sos product is essential for its function. Membrane localization of Sos protein is independent of drk function. A drk-independent interaction between Sos and sev has been proposed that is likely mediated by the pleckstrin homology domain within the amino terminus of Sos.
                      The role of the N and C terminal regions of Sos are studied in mammalian cells to directly measure the effect on p21ras loading with GTP. Results demonstrate a functional role for pleckstrin and Dbl domains within the Sos protein.
                      A high affinity binding site for the drk SH3 domain maps to the Sos product tail. The N-terminal drk SH3 domain is primarily responsible for binding to the tail of the Sos product in vitro, and for signalling to the Ras85D product in vivo.
                      Experiments on Ras activation in signal transduction by human insulin receptor in COS cells found heterologously expressed Sos gene product in a complex with insulin receptor and GRB2 or p85.
                      Dosage-dependent genetic interaction between S and sev, Ras85D and Sos (involved in receptor tyrosine kinase signalling) supports a role for S in cell-cell signalling.
                      Heat shock induced expression, embryonic injection and female mosaic analysis demonstrates that Ras85D and its positive regulator Sos are involved in the tor signalling pathway.
                      In vitro, drk binds the C terminal tail of the Sos product through the drk SH3 domain, thereby linking receptor tyrosine kinases to Ras activation.
                      Sos has been cloned and sequenced.
                      The Sos gene product is common to the sev as well as the Egfr receptor tyrosine kinase pathway but the interaction of Sos with Egfr is limited to the developing eye. Suppression of sev by Sos is allele specific.
                      Sos is required for photoreceptor development, acts in R7 and is a suppressor of the Egfr phenotype to restore the eye to a nearly normal appearance.
                      Recessive lethal or semi-lethal; heteroallelic or hemizygous escapers have small rough eyes; heterozygotes between two weak alleles viable with rough eyes.
                      Origin and Etymology
                      Discoverer
                      Etymology
                      Identification
                      External Crossreferences and Linkouts ( 134 )
                      Sequence Crossreferences
                      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                      Linkouts
                      BioGRID - A database of protein and genetic interactions.
                      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
                      DroID - A comprehensive database of gene and protein interactions.
                      DRSC - Results frm RNAi screens
                      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                      Flygut - An atlas of the Drosophila adult midgut
                      FlyMine - An integrated database for Drosophila genomics
                      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                      KEGG Genes - Molecular building blocks of life in the genomic space.
                      MIST (genetic) - An integrated Molecular Interaction Database
                      MIST (protein-protein) - An integrated Molecular Interaction Database
                      modMine - A data warehouse for the modENCODE project
                      SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                      Synonyms and Secondary IDs (30)
                      Reported As
                      Symbol Synonym
                      E(var)189
                      l(2)Sos
                      l(2)k06321
                      Secondary FlyBase IDs
                      • FBgn0013235
                      • FBgn0026802
                      Datasets (1)
                      Study focus (1)
                      Experimental Role
                      Project
                      Project Type
                      Title
                      • bait_protein
                      Interaction map generated by purification of receptor tyrosine kinase pathway factors, with identification of copurifying proteins by mass spectrometry.
                      References (312)