FlyBase Gene Report: Dmel\NimC3

General Information

Symbol

Dmel\NimC3

Species

D. melanogaster

Name

Nimrod C3

Annotation Symbol

CG16880

Feature Type

protein_coding_gene

FlyBase ID

FBgn0001967

Gene Model Status

Current

Stock Availability

9 publicly available

Gene Summary

Nimrod C3 (NimC3) encodes a member of the highly conserved Nimrod cluster. It is a transmembrane protein with a putative phagocytosis receptor function. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

l(2)br30, l(2)k00811, br30, BG:DS05899.2 , l(2)34Fa

Key Links

Genomic Location

Cytogenetic map

34F1-34F1

Sequence location

2L:14,019,357..14,020,208 [-]

Recombination map

2-50

RefSeq locus

NT_033779 REGION:14019357..14020208

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (4 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in immune response

inferred from biological aspect of ancestor with PANTHER:PTN001171370

(GO Reference Genome Project, 2011-)

involved_in phagocytosis

inferred from sequence or structural similarity with FLYBASE:NimC1; FB:FBgn0259896

(Kurucz et al., 2007)

inferred from biological aspect of ancestor with PANTHER:PTN001171370

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in membrane

inferred from sequence model

(FlyBase Curators, 2011-)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN004653852

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

NIMROD-TYPE RECEPTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Epidermal growth factor-like domain-containing protein

Summaries

Gene Snapshot

Nimrod C3 (NimC3) encodes a member of the highly conserved Nimrod cluster. It is a transmembrane protein with a putative phagocytosis receptor function. [Date last reviewed: 2019-03-14]

Gene Group (FlyBase)

NIMROD-TYPE RECEPTORS -: The Nimrod family of genes is characterised by the presence of NIM repeats, closely related to the EGF-repeat. They encode proteins which are secreted or integral to the plasma membrane. The Nimrod genes have been linked to the innate immune response and some members of this family have been shown to act as receptors for bacterial or apoptic cell phagocytosis. (Adapted from FBrf0212245).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\NimC3 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VJU2)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.42

Gene model reviewed during 5.43

Gene model reviewed during 5.52

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

NimC3-RB

FBtr0290243

NM_080189

852

224

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

NimC3-PB

FBpp0288682

25.3

224

6.17

Q9VJU2

NP_524928

AAF53369

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Epidermal growth factor-like domain-containing protein

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VJU2

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\NimC3 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

NimC3_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.17

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\NimC3 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\NimC3

View exonic expression by tissue for Dmel\NimC3

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

48772/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0001967

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0001967

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0001967

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG16880

Flygut - An atlas of the Drosophila adult midgut

FBgn0001967

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of NimC3

Transgenic constructs containing regulatory region of NimC3

Aberrations (Deficiencies and Duplications) ( 133 )

Inferred from experimentation ( 133 )

Gene disrupted in

Df(2L)A47

(Fossett et al., 1994, Gubb et al., 1990, Ashburner et al., 1982)

Df(2L)A263

(Ashburner et al., 1982)

Df(2L)A376

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)Adh-nBR41

(Roote et al., 1996)

Df(2L)Adh-nBR101

(Fossett et al., 1994)

Df(2L)Adh-nBR130

(Fossett et al., 1994)

Df(2L)Adh-nBR131

(Roote, 1996.1.11, Roote, 1996.8)

Df(2L)b75

(Gubb et al., 1990)

Df(2L)b77c

(Roote, 2000.7.3, Alexandrova et al., 1996)

Df(2L)b79b3

(Alexandrova et al., 1996, Roote, 1995.3.27)

Df(2L)b81f1A

(Roote, 1995.3.27)

Df(2L)b81f2A

(Alexandrova et al., 1996)

Df(2L)b84h14

(Alexandrova et al., 1996, Roote, 1995.3.27)

Df(2L)b84h50

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Df(2L)b85c1

(Alexandrova et al., 1996, Roote, 1995.3.27)

Df(2L)b87g23

(Alexandrova et al., 1996)

Df(2L)b88f40

(Roote, 2000.6.5, Roote, 2000.7.3)

Df(2L)b88f43

(Roote, 1996.8, Roote, 1995.3.27)

Df(2L)b88g96

(Roote, 1996.8, Roote, 1995.3.27)

Df(2L)b89e8

(Roote, 2000.6.5, Roote, 2000.7.3)

Df(2L)b89e64b

(Roote, 2000.6.5)

Df(2L)b89e72

(Roote, 2000.6.5, Roote, 2000.7.3)

(Roote, 2000.6.5)

(Roote, 1998.3.17)

(Roote, 1995.5.13)

(Ryder, 2004.4.26)

(Ashburner et al., 1982)

Df(2L)fn12

(Ashburner et al., 1982)

Df(2L)fn26

(Ashburner et al., 1982)

Df(2L)fn30

(Ashburner et al., 1982)

Df(2L)fn31

(Ashburner et al., 1982)

Df(2L)GT4

(Roote et al., 1996, Gubb et al., 1990)

Df(2L)GT5

(Gubb et al., 1990)

Df(2L)k07245^Lk00811^R-mr2

(Roote, 2000.6.13)

Df(2L)k07245^Lk00811^R-mr3

(Roote, 2000.6.13)

Df(2L)k07245^Lk00811^R-mr4

(Roote, 2000.6.13)

Df(2L)k07245^Lk00811^R-mr5

(Roote, 2000.6.13)

Df(2L)k07245^Lk00811^R-mr6

(Roote, 2000.6.13)

Df(2L)k07245^Lk00811^R-mr7

(Roote, 2000.6.13)

Df(2L)k07245^Lk00811^R-mr8

(Roote, 2000.6.13)

Df(2L)k07245^Lk00811^R-mr10

(Roote, 2000.6.13)

Df(2L)k07245^Lk00811^R-mr11

(Roote, 2000.6.13)

Df(2L)k07245^Lk00811^R-mr13

(Roote, 2000.6.13)

Df(2L)k07245^Lk00811^R-mr14

(Roote, 2000.6.13)

Df(2L)k07245^Lk00811^R-mr15

(Roote, 2000.6.13)

Df(2L)k07245^Lk00811^R-mr16

(Roote, 2000.6.13)

Df(2L)k07245^Lk00811^R-mr17

(Roote, 2000.6.13)

Df(2L)k07245^Lk05605^R-mr6

(Roote, 2000.6.13)

Df(2L)k07245^Lk05605^R-mr8

(Roote, 2000.6.13)

Df(2L)noc10

(Roote et al., 1996)

Df(2L)noc20

(Roote et al., 1996)

Df(2L)osp141

(Roote et al., 1996)

Df(2L)rN149-rv3

(Roote, 2000.6.13)

Df(2L)Sco^rv23

(Ashburner and Harrington, 1984)

Df(2L)TE35B-3

(Roote et al., 1996, Gubb et al., 1985)

Df(2L)TE35B-4

(Roote et al., 1996, Gubb et al., 1985)

Df(2L)TE35B-5

(Gubb et al., 1985)

Df(2L)TE35B-8

(Roote et al., 1996, Gubb et al., 1985)

Df(2L)TE35B-9

(Roote et al., 1996, Gubb et al., 1985)

Df(2L)TE35BC-6

(Gubb et al., 1984)

Df(2L)TE35BC-23

(Gubb et al., 1984)

Df(2L)TE35BC-29

(Gubb et al., 1984)

Df(2L)TE35BC-31

(Gubb et al., 1984)

Df(2L)W

(Roote et al., 1996)

Gene duplicated in

Dp(2;1;3;f)Sco^rv23-X6

Dp(2;1;f)Sco^rv23-X2

Dp(2;1)Sco^rv23

(Ashburner and Harrington, 1984)

Dp(2;Y)b88b15

(Roote, 1996.8)

Gene partially disrupted in

Df(2L)el20

(Ashburner et al., 1999.10.12)

Gene not disrupted in

Df(2L)A48

(Fossett et al., 1994, Gubb et al., 1990, Ashburner et al., 1982)

Df(2L)A63

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A72

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A178

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A215

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A217

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A220

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A245

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A246

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A260

(Ashburner et al., 1982)

Df(2L)A264

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A266

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A267

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A337

(Fossett et al., 1994)

Df(2L)A377

(Ashburner et al., 1982)

Df(2L)A379

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A400

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)A445

(Fossett et al., 1994, Ashburner et al., 1982)

Df(2L)Adh-nBR100

(Roote, 1996.1.11, Roote, 1996.8, Fossett et al., 1994)

Df(2L)Adh-nBR102

(Fossett et al., 1994)

Df(2L)Adh-nBR103

(Roote, 1996.1.11, Roote, 1996.8, Fossett et al., 1994)

Df(2L)Adh-nBR105

(Fossett et al., 1994)

Df(2L)Adh-nBR106

(Fossett et al., 1994)

Df(2L)Adh-nBR107

(Fossett et al., 1994)

Df(2L)Adh-nBR117

(Fossett et al., 1994)

Df(2L)Adh-nBR118

(Fossett et al., 1994)

Df(2L)Adh-nBR119

(Fossett et al., 1994)

Df(2L)Adh-nBR120

(Roote, 1996.1.11, Roote, 1996.8, Fossett et al., 1994)

Df(2L)Adh-nBR121

(Fossett et al., 1994)

Df(2L)Adh-nBR122

(Fossett et al., 1994)

Df(2L)Adh-nBR125

(Roote, 1996.1.11, Roote, 1996.8, Fossett et al., 1994)

Df(2L)Adh-nBR126

(Fossett et al., 1994)

Df(2L)Adh-nBR127

(Fossett et al., 1994)

Df(2L)Adh-nBR128

(Fossett et al., 1994)

Df(2L)Adh-nBR129

(Fossett et al., 1994)

Df(2L)Adh-nBR131

(Fossett et al., 1994)

Df(2L)b80c1

(Ashburner et al., 1982)

Df(2L)b91l5

(Roote, 2000.7.3)

Df(2L)fn1

(Ashburner et al., 1982)

Df(2L)fn2

(Ashburner et al., 1982)

Df(2L)fn3

(Ashburner et al., 1982)

Df(2L)fn5

(Ashburner et al., 1982)

Df(2L)fn15

(Ashburner et al., 1982)

Df(2L)fn27

(Ashburner et al., 1982)

Df(2L)fn36

(Ashburner et al., 1982)

Df(2L)osp38

(Roote, 1996.8)

Df(2L)TE35B-1

(Gubb et al., 1985)

Df(2L)TE35B-2

(Gubb et al., 1985)

Df(2L)TE35B-6

(Gubb et al., 1985)

Df(2L)TE35B-7

(Gubb et al., 1985)

Df(2L)TE35B-10

(Gubb et al., 1985)

Df(2L)TE35B-11

(Gubb et al., 1985)

Df(2L)TE35B-12

(Gubb et al., 1985)

Df(2L)TE35B-15

(Gubb et al., 1985)

Df(2L)TE35BC-1

(Gubb et al., 1984)

Df(2L)TE35BC-3

(Gubb et al., 1984)

Df(2L)TE35BC-4

(Gubb et al., 1984)

Df(2L)TE35BC-7

(Gubb et al., 1984)

Df(2L)TE35BC-8

(Gubb et al., 1984)

Df(2L)TE35BC-24

(Gubb et al., 1984)

Df(2L)TE35BC-28

(Gubb et al., 1984)

Df(2L)TE35BC-34

(Gubb et al., 1984)

Df(2L)TE35BC-35

(Gubb et al., 1984)

In(2L)TE35B-13

(Gubb et al., 1985)

T(2;3)H147

(Roote, 1997.6.2)

Tp(2;2)A446

(Fossett et al., 1994, Ashburner et al., 1982)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | recessive

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

NimC3^GD12708

viable, with Scer\GAL4^Mef2.PR

NimC3^GD12708

viable, with Scer\GAL4^pnr-MD237

NimC3^GD12708

Other Phenotypes

Allele

abnormal immune response | adult stage, with Scer\GAL4^Hml.Δ

NimC3^GD12708

short lived | conditional, with Scer\GAL4^Hml.Δ

NimC3^GD12708

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (23)

Hsap\CCBE1

1 of 14

Yes

Hsap\DKK1

1 of 14

Yes

Hsap\DKK2

1 of 14

Yes

Hsap\DKK3

1 of 14

Yes

Hsap\DKK4

1 of 14

Yes

Hsap\ESM1

1 of 14

Yes

Hsap\FAT1

1 of 14

Yes

Hsap\MEGF6

1 of 14

Yes

Hsap\MEGF10

1 of 14

Yes

Hsap\MEGF11

1 of 14

Yes

Hsap\PEAR1

1 of 14

Yes

Hsap\SCARF1

1 of 14

Yes

Hsap\SCARF2

1 of 14

Yes

Hsap\STAB1

1 of 14

Yes

Hsap\STAB2

1 of 14

Yes

Hsap\SVEP1

1 of 14

Yes

Hsap\TENM2

1 of 14

Yes

Hsap\TENM3

1 of 14

Yes

Hsap\TNC

1 of 14

Yes

Hsap\TNFAIP6

1 of 14

Yes

Hsap\TNXB

1 of 14

Yes

Hsap\VWDE

1 of 14

Yes

Hsap\WIF1

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (14)

Rnor\Dkk1

1 of 14

Yes

Rnor\Dkk2

1 of 14

Yes

Rnor\Dkk3

1 of 14

Yes

Rnor\Dkk4

1 of 14

Yes

Rnor\Esm1

1 of 14

Yes

Rnor\Megf6

1 of 14

Yes

Rnor\Megf10

1 of 14

Yes

Rnor\Pear1

1 of 14

Yes

Rnor\Scarf2

1 of 14

Yes

Rnor\Stab1

1 of 14

Yes

Rnor\Stab2

1 of 14

Yes

Rnor\Tenm3

1 of 14

Yes

Rnor\Tnfaip6

1 of 14

Yes

Rnor\Wif1

1 of 14

Yes

Mus musculus (laboratory mouse) (20)

Mmus\Ccbe1

1 of 14

Yes

Mmus\Dkk1

1 of 14

Yes

Mmus\Dkk2

1 of 14

Yes

Mmus\Dkk3

1 of 14

Yes

Mmus\Dkk4

1 of 14

Yes

Mmus\Egfem1

1 of 14

Yes

Mmus\Egfl6

1 of 14

Yes

Mmus\Esm1

1 of 14

Yes

Mmus\Megf6

1 of 14

Yes

Mmus\Megf10

1 of 14

Yes

Mmus\Megf11

1 of 14

Yes

Mmus\Pear1

1 of 14

Yes

Mmus\Scarf1

1 of 14

Yes

Mmus\Scarf2

1 of 14

Yes

Mmus\Stab1

1 of 14

Yes

Mmus\Stab2

1 of 14

Yes

Mmus\Tenm3

1 of 14

Yes

Mmus\Tnfaip6

1 of 14

Yes

Mmus\Tnxb

1 of 14

Yes

Mmus\Wif1

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (6)

Xtro\adgre2

1 of 13

Yes

Xtro\egf

1 of 13

Yes

Xtro\fat1

1 of 13

Yes

Xtro\LOC101730707

1 of 13

Yes

Xtro\pear1

1 of 13

Yes

Xtro\tnn

1 of 13

Yes

Danio rerio (Zebrafish) (13)

Drer\ccbe1

1 of 14

Yes

Drer\dkk1a

1 of 14

Yes

Drer\dkk1b

1 of 14

Yes

Drer\dkk2

1 of 14

Yes

Drer\dkk3b

1 of 14

Yes

Drer\megf6b

1 of 14

Yes

Drer\megf11

1 of 14

Yes

Drer\pear1

1 of 14

Yes

Drer\stab1

1 of 14

Yes

Drer\stab2

1 of 14

Yes

Drer\tnfaip6

1 of 14

Yes

Drer\vwdel

1 of 14

Yes

Drer\wif1

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (16)

Cele\C53B7.2

1 of 14

Yes

Cele\cpg-24

1 of 14

Yes

Cele\D1044.7

1 of 14

Yes

Cele\dsl-1

1 of 14

Yes

Cele\dsl-2

1 of 14

Yes

Cele\dsl-5

1 of 14

Yes

Cele\dsl-6

1 of 14

Yes

Cele\dsl-7

1 of 14

Yes

Cele\F07H5.8

1 of 14

Yes

Cele\F46B3.15

1 of 14

Yes

Cele\F56B3.2

1 of 14

Yes

Cele\lag-2

1 of 14

Yes

Cele\M03F4.6

1 of 14

Yes

Cele\pqn-25

1 of 14

Yes

Cele\sdz-23

1 of 14

Yes

Cele\T01D3.1

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (9)

Agam\AgaP_AGAP009762

3 of 12

Yes

Agam\AgaP_AGAP009763

3 of 12

Yes

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:NimC3. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (16)

5 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

shf

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Other Interaction Browsers

Summary of Genetic Interactions

esyN Network Diagram

Other Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

71674

DroID - A comprehensive database of gene and protein interactions.

FBgn0001967

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-50

Cytogenetic map

34F1-34F1

Sequence location

2L:14,019,357..14,020,208 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

34F1-34F1

Limits computationally determined from genome sequence between P{lacW}Sos^k05224&P{lacW}RpII33^k05605 and P{lacW}l(2)34Fa^k00811&P{PZ}wb⁰⁹⁴³⁷

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

35A1-35A2

(determined by in situ hybridisation)

(Ashburner et al., 1999, Spradling et al., 1999)

35A1-35A2

(BDGP Project Members, 1994-1999)

Experimentally Determined Recombination Data

Location

2-50

(FlyBase, 2016)

2-45.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

17054

w¹¹¹⁸; P{EP}NimC3^EP2418

10487

y¹ w^67c23; P{lacW}NimC3^k00811/CyO

3439

NimC3¹ Adhⁿ¹ PolD3^rd-s pr¹ cn¹, l(2)CA3^CR5/CyO

Kyoto

114340

y^d2 w¹¹¹⁸ P{ey-FLP.N}2; P{lacW}NimC3^k00811 P{neoFRT}40A/CyO y⁺

NIG-Fly

M2L-1104

y¹ w¹¹¹⁸; NimC3^SK4 P{neoFRT}40A/CyO-Tb

M2L-1105

y¹ w¹¹¹⁸; NimC3^SK6 P{neoFRT}40A/CyO-Tb

2LG-0881

y² VhaAC39-1^cho-1 v¹; P{U6-NimC3.NIG.sgRNA}attP40/CyO

VDRC

v103668

P{KK112612}VIE-260B

v22920

w¹¹¹⁸; P{GD12708}v22920

Genomic Clones (10)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (0)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0001967

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0001967

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Source for merge of: l(2)34Fa CG16880

(Misra, 2000.4.12)

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: nimC3 l(2)34Fa

(Kurucz et al., 2007)

Source for identity of: NimC3 nimC3

(FlyBase, 2009-)

Nomenclature comments

Etymology

The "nimrod" gene cluster is dubbed after Nimrod, the biblical "mighty hunter before the Lord" (Genesis 10), who according to Gesta Hungarorum was also the ancestor of all Hungarians (Kezai Simon, Gesta Hunnorum et Hungarorum A.D. 1282).

(Kurucz et al., 2007)

Synonyms and Secondary IDs (13)

Reported As

Symbol Synonym

BG:DS05899.2

(Ashburner et al., 1999, Ashburner et al., 1999.10.12)

CG16880

(National Institute of Genetics Fly Stocks, 2022-, Okuda et al., 2016, Hosono et al., 2015, Keleman et al., 2009.8.5, Bhutkar et al., 2008, Kurucz et al., 2007)

I(2)34Fa

(Ogura et al., 2009)

NimC3

(Chen et al., 2023, National Institute of Genetics Fly Stocks, 2022-, Lu et al., 2020, Somogyi et al., 2008, Kurucz et al., 2007)

br30

(Gubb et al., 1985, Ashburner and Harrington, 1984)

l(2)34Fa

(Bhutkar et al., 2008)

l(2)br30

(Gubb et al., 1984, Ashburner et al., 1982)

l(2)k00811

(Chen et al., 1998, Chen et al., 1998)

l34Fa

(Fossett et al., 1994)

nimC3

(DeSalvo et al., 2014, Somogyi et al., 2010, Kurucz et al., 2007)

Name Synonyms

Nimrod C3

(Okuda et al., 2016)

lethal (2) 34Fa

nimrod C3

Secondary FlyBase IDs

FBgn0032542

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 28 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

48772

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VJU2

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9VJU2

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VJU2

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

48772/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0001967

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0001967

FlyMine - An integrated database for Drosophila genomics

FBgn0001967

InterPro - A database of protein families, domains and functional sites

Epidermal growth factor-like domain-containing protein

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG16880

MARRVEL_MODEL - MARRVEL (model organism gene)

48772

Linkouts

BioGRID - A database of protein and genetic interactions.

71674

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0001967

DroID - A comprehensive database of gene and protein interactions.

FBgn0001967

DRSC - Results frm RNAi screens

FBgn0001967

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

NimC3_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0001967

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0001967

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG16880

Flygut - An atlas of the Drosophila adult midgut

FBgn0001967

References (70)

The following external sites may use different assemblies or annotations than FlyBase.

-0.17

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