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Gene Dmel\stc

General Information
Symbol	Dmel\stc	Species	D. melanogaster
Name	shuttle craft	Annotation symbol	CG3647
Feature type	protein_coding_gene	FlyBase ID	FBgn0001978
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	l(2)35Cb, l(2)br33, br33, BG:DS04929.4
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	35C2-35C2	Sequence location	2L:15,113,480..15,118,069 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene shuttle craft is referred to in FlyBase by the symbol Dmel\stc (CG3647, FBgn0001978). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: sequence-specific DNA binding transcription factor activity. Based on sequence similarity, it is predicted to be involved in the biological process: regulation of transcription, DNA-dependent. 15 alleles are reported. The phenotypes of these alleles are annotated with: central nervous system; intersegmental nerve; abdominal segmental nerve. It has 4 annotated transcripts and 4 annotated polypeptides. Protein features are: Single-stranded nucleic acid binding R3H; Zinc finger, NF-X1-type; Zinc finger, PHD-type, conserved site; Zinc finger, RING-type. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult ovary, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult testis, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1640237_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of stc. Gene sequence location is 2L:15113480..15118069.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	l(2)35Cb l(2)35Cb1 escapes in heterozygous combination with Df(2L)Sco4, but not with other l(2)35Cb deficiencies.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 35C2-35C2   Limits computationally determined from genome sequence between P{EP}vigEP812&P{PZ}stc05441 and P{EP}esgEP633&P{PZ}esg07082
Experimentally Determined Cytological Location
Cytogenetic map Notes References 34C4-36A7     (Oh et al., 2003) 35C1-35C2   (determined by in situ hybridisation)   (Ashburner et al., 1999) 35C1-35C2   (determined by in situ hybridisation)   (Spradling et al., 1999) 35C-35C   (determined by in situ hybridisation)   (Stroumbakis et al., 1996) 35C1-35C2     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\stc for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) stc-RA FBtr0080706  NM_057250   4124   1099 stc-RB FBtr0080705  NM_057251   4145   1106 stc-RC FBtr0332473  NM_001273531   4112   1095 stc-RD FBtr0332474  NM_001273532   4133   1102
Additional Transcript Data & Comments
Reported size (kB)	4.0 (northern blot) (Stroumbakis et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein stc-PA   FBpp0080266   122.4   1099   8.34     NP_476598   AAN10891 stc-PB   FBpp0080265   123.2   1106   8.34     NP_476599   AAF53441 stc-PC   FBpp0304749   121.9   1095   8.34     NP_001260460   AGB92995 stc-PD   FBpp0304750   122.7   1102   8.34     NP_001260461   AGB92996
Additional Polypeptide Data & Comments
Reported size (kDa)	1106, 1099 (aa); 123 (kD predicted) (Stroumbakis et al., 1996)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, NF-X1-type (IPR000967) Single-stranded nucleic acid binding R3H (IPR001374) Zinc finger, RING-type (IPR001841) Zinc finger, PHD-type, conserved site (IPR019786)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202170   AA390475   AA390501   AA391078   AA820112   AA941360   AA941373   AA948858   AA952254   AA978739   AE014134 AAF53441   AE014134 AAN10891   AB082587   AE003412 AAF44922   AF145679 AAD38654   AE014134 AGB92995   AE014134 AGB92996   AI455296   BF486760   BF491441   BF497142   BF497530   BF498285   BF506177   BF506288   BF506626   BG635063   BI165083   BI171004   BI214340   BI214520   BI216567   BI216705   BI230509   BI230571   BI231925   BI235375   BI236500   BI237045   BI238284   BI241981   BI361947   BI371766   BI632546   BI633844   BI639349   BP544150   BP544151   BT125955   CO288504   CO290210   CO309003   CO311017   CO312388   CO313213   CO325380   CO328754   CO335352   EC070162   EC074912   EC202254   EC204804   EC207789   EC236679   EC263134   EL873018   EV576764   EV578122   EV599578   G00414   GH749783   GH749987   GH750948   GH754392   GH774861   GH780874   GH781596   GH782096   GH784817   GH784832   GH788908   GH799410   GH804387   GH810818   GH811168   GH812037   GH812353   GH812642   GH820546   GH823494   GH825650   GH827753   GH827779   GH828464   GH829827   GH837694   GH849670   GH852330   GH852570   GH858576   GH859121   GH861061   GH866099   GH870091   GH872578   GH875557   GH876447   GH876786   GH877050   GH881975   GH882395   GH889411   GH895668   GH907811   GH918859   GH920108   GH920273   GH923418   GH924964   GH927273   GH931588   U09306 AAB60255
UniProtKB/Swiss-Prot	P40798
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) pole cell   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) pole cell   (Fisher et al., 2012) embryonic stage 9 -- 10   germline cell   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | ubiquitous   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Stroumbakis et al., 1996) oogenesis & adult stage | female   ovary   (Stroumbakis et al., 1996)
Additional Descriptive Data
	stc transcripts are detected throughout development on northern blots. They are most abundant in adult males and in ovaries. (Stroumbakis et al., 1996)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 13 -- 17   embryonic/larval brain | restricted   (Stroumbakis et al., 1996) presumptive embryonic/larval central nervous system | restricted   (Stroumbakis et al., 1996)
Additional Descriptive Data
	stc protein was detected in the central nervous system of stage 13-17 embryos. It is prominent in repeated clusters of cells in each neuromere along the length of the ventral nerve cord and in distinct groups of cells within the brain lobes. (Stroumbakis et al., 1996)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nucleus inferred from direct assay (Stroumbakis et al., 1996)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult ovary, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult testis, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    235.525 Larval Midgut    199.3 Larval Hindgut    158.3 Larval Malpighian Tubules    131.6 Larval Fat Body    140.7 Larval Salivary Gland    394.4 Larval Trachea    171.1 Larval Carcass    235.35 Adult Head    116.1 Adult Eye    107.6 Adult Brain    194.4 Adult Thoracic-Abdominal Ganglion    168.7 Adult Crop    180.1 Adult Midgut    218 Adult Hindgut    148.6 Adult Malpighian Tubules    212.2 Adult Fat Body    171.8 Adult Salivary Gland    242.5 Adult Heart    92.95 Adult VirginFemale Spermatheca    246.8 Adult InseminatedFemale Spermatheca    294.5 Adult Ovary    544.2 Adult Testis    339.6 Adult Male Accessory Gland    617.7 Adult Carcass    106.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    235.525 Larval Midgut    199.3 Larval Hindgut    158.3 Larval Malpighian Tubules    131.6 Larval Fat Body    140.7 Larval Salivary Gland    394.4 Larval Trachea    171.1 Larval Carcass    235.35 Adult Head    116.1 Adult Eye    107.6 Adult Brain    194.4 Adult Thoracic-Abdominal Ganglion    168.7 Adult Crop    180.1 Adult Midgut    218 Adult Hindgut    148.6 Adult Malpighian Tubules    212.2 Adult Fat Body    171.8 Adult Salivary Gland    242.5 Adult Heart    92.95 Adult VirginFemale Spermatheca    246.8 Adult InseminatedFemale Spermatheca    294.5 Adult Ovary  (544.2) Adult Testis    339.6 Adult Male Accessory Gland  (617.7) Adult Carcass    106.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    235.525 Larval Midgut    199.3 Larval Hindgut    158.3 Larval Malpighian Tubules    131.6 Larval Fat Body    140.7 Larval Salivary Gland    394.4 Larval Trachea    171.1 Larval Carcass    235.35 Adult Head    116.1 Adult Eye    107.6 Adult Brain    194.4 Adult Thoracic-Abdominal Ganglion    168.7 Adult Crop    180.1 Adult Midgut    218 Adult Hindgut    148.6 Adult Malpighian Tubules    212.2 Adult Fat Body    171.8 Adult Salivary Gland    242.5 Adult Heart    92.95 Adult VirginFemale Spermatheca    246.8 Adult InseminatedFemale Spermatheca    294.5 Adult Ovary    544.2 Adult Testis    339.6 Adult Male Accessory Gland    617.7 Adult Carcass    106.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    235.525 Larval Midgut    199.3 Larval Hindgut    158.3 Larval Malpighian Tubules    131.6 Larval Fat Body    140.7 Larval Salivary Gland    394.4 Larval Trachea    171.1 Larval Carcass    235.35 Adult Head    116.1 Adult Eye    107.6 Adult Brain    194.4 Adult Thoracic-Abdominal Ganglion    168.7 Adult Crop    180.1 Adult Midgut    218 Adult Hindgut    148.6 Adult Malpighian Tubules    212.2 Adult Fat Body    171.8 Adult Salivary Gland    242.5 Adult Heart    92.95 Adult VirginFemale Spermatheca    246.8 Adult InseminatedFemale Spermatheca    294.5 Adult Ovary    544.2 Adult Testis    339.6 Adult Male Accessory Gland    617.7 Adult Carcass    106.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    235.525 Larval Midgut    199.3 Larval Hindgut    158.3 Larval Malpighian Tubules    131.6 Larval Fat Body    140.7 Larval Salivary Gland    394.4 Larval Trachea    171.1 Larval Carcass    235.35 Adult Head    116.1 Adult Eye    107.6 Adult Brain    194.4 Adult Thoracic-Abdominal Ganglion    168.7 Adult Crop    180.1 Adult Midgut    218 Adult Hindgut    148.6 Adult Malpighian Tubules    212.2 Adult Fat Body    171.8 Adult Salivary Gland    242.5 Adult Heart    92.95 Adult VirginFemale Spermatheca    246.8 Adult InseminatedFemale Spermatheca    294.5 Adult Ovary    544.2 Adult Testis    339.6 Adult Male Accessory Gland    617.7 Adult Carcass    106.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    235.525 Larval Midgut    199.3 Larval Hindgut    158.3 Larval Malpighian Tubules    131.6 Larval Fat Body    140.7 Larval Salivary Gland    394.4 Larval Trachea    171.1 Larval Carcass    235.35 Adult Head    116.1 Adult Eye    107.6 Adult Brain    194.4 Adult Thoracic-Abdominal Ganglion    168.7 Adult Crop    180.1 Adult Midgut    218 Adult Hindgut    148.6 Adult Malpighian Tubules    212.2 Adult Fat Body    171.8 Adult Salivary Gland    242.5 Adult Heart    92.95 Adult VirginFemale Spermatheca    246.8 Adult InseminatedFemale Spermatheca    294.5 Adult Ovary  544.2 Adult Testis    339.6 Adult Male Accessory Gland  617.7 Adult Carcass    106.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    235.525 Larval Midgut    199.3 Larval Hindgut    158.3 Larval Malpighian Tubules    131.6 Larval Fat Body    140.7 Larval Salivary Gland    394.4 Larval Trachea    171.1 Larval Carcass    235.35 Adult Head    116.1 Adult Eye    107.6 Adult Brain    194.4 Adult Thoracic-Abdominal Ganglion    168.7 Adult Crop    180.1 Adult Midgut    218 Adult Hindgut    148.6 Adult Malpighian Tubules    212.2 Adult Fat Body    171.8 Adult Salivary Gland    242.5 Adult Heart    92.95 Adult VirginFemale Spermatheca    246.8 Adult InseminatedFemale Spermatheca    294.5 Adult Ovary    544.2 Adult Testis    339.6 Adult Male Accessory Gland    617.7 Adult Carcass    106.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    235.525 Larval Midgut    199.3 Larval Hindgut    158.3 Larval Malpighian Tubules    131.6 Larval Fat Body    140.7 Larval Salivary Gland    394.4 Larval Trachea    171.1 Larval Carcass    235.35 Adult Head    116.1 Adult Eye    107.6 Adult Brain    194.4 Adult Thoracic-Abdominal Ganglion    168.7 Adult Crop    180.1 Adult Midgut    218 Adult Hindgut    148.6 Adult Malpighian Tubules    212.2 Adult Fat Body    171.8 Adult Salivary Gland    242.5 Adult Heart    92.95 Adult VirginFemale Spermatheca    246.8 Adult InseminatedFemale Spermatheca    294.5 Adult Ovary    544.2 Adult Testis    339.6 Adult Male Accessory Gland    617.7 Adult Carcass    106.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    116.1   NA  Eye    107.6   NA  Brain    194.4   235.525  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    168.7   NA  Crop    180.1   199.3  Midgut    218   158.3  Hindgut    148.6   131.6  Malpighian Tubules    212.2   140.7  Fat Body    171.8   394.4  Salivary Gland    242.5   NA  Heart    92.95   171.1  Trachea    NA   NA  VirginFemale Spermatheca    246.8   NA  InseminatedFemale Spermatheca    294.5   NA  Ovary    544.2   NA  Testis    339.6   NA  Male Accessory Gland    617.7   235.35  Carcass    106.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    27 central nervous system, larvae L3    17 central nervous system, pupae P8    9 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    7 head, mated 1-day male    8 head, mated 4-day male    10 head, mated 20-day male    11 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    10 digestive system, 4-day adult    14 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    8 fat body, pupae P8    9 carcass, larvae L3 wandering    15 carcass, 1-day adult    8 carcass, 4-day adult    11 carcass, 20-day adult    9 ovary, virgin 4-day female    64 ovary, mated 4-day female    61 testis, mated 4-day male    32 accessory gland, mated 4-day male    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (27) central nervous system, larvae L3    17 central nervous system, pupae P8    9 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    7 head, mated 1-day male    8 head, mated 4-day male    10 head, mated 20-day male    11 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    10 digestive system, 4-day adult    14 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    8 fat body, pupae P8    9 carcass, larvae L3 wandering    15 carcass, 1-day adult    8 carcass, 4-day adult    11 carcass, 20-day adult    9 ovary, virgin 4-day female  (64) ovary, mated 4-day female  (61) testis, mated 4-day male  (32) accessory gland, mated 4-day male    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    27 central nervous system, larvae L3    17 central nervous system, pupae P8    9 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    7 head, mated 1-day male    8 head, mated 4-day male    10 head, mated 20-day male    11 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    10 digestive system, 4-day adult    14 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    8 fat body, pupae P8    9 carcass, larvae L3 wandering    15 carcass, 1-day adult    8 carcass, 4-day adult    11 carcass, 20-day adult    9 ovary, virgin 4-day female    64 ovary, mated 4-day female    61 testis, mated 4-day male    32 accessory gland, mated 4-day male    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    27 central nervous system, larvae L3    17 central nervous system, pupae P8    9 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    7 head, mated 1-day male    8 head, mated 4-day male    10 head, mated 20-day male    11 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    10 digestive system, 4-day adult    14 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    8 fat body, pupae P8    9 carcass, larvae L3 wandering    15 carcass, 1-day adult    8 carcass, 4-day adult    11 carcass, 20-day adult    9 ovary, virgin 4-day female    64 ovary, mated 4-day female    61 testis, mated 4-day male    32 accessory gland, mated 4-day male    21 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    27 central nervous system, larvae L3    17 central nervous system, pupae P8    9 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    7 head, mated 1-day male    8 head, mated 4-day male    10 head, mated 20-day male    11 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    10 digestive system, 4-day adult    14 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    8 fat body, pupae P8    9 carcass, larvae L3 wandering    15 carcass, 1-day adult    8 carcass, 4-day adult    11 carcass, 20-day adult    9 ovary, virgin 4-day female    64 ovary, mated 4-day female    61 testis, mated 4-day male    32 accessory gland, mated 4-day male    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  27 central nervous system, larvae L3    17 central nervous system, pupae P8    9 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    7 head, mated 1-day male    8 head, mated 4-day male    10 head, mated 20-day male    11 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    10 digestive system, 4-day adult    14 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    8 fat body, pupae P8    9 carcass, larvae L3 wandering    15 carcass, 1-day adult    8 carcass, 4-day adult    11 carcass, 20-day adult    9 ovary, virgin 4-day female  (64) ovary, mated 4-day female  (61) testis, mated 4-day male  32 accessory gland, mated 4-day male    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    27 central nervous system, larvae L3    17 central nervous system, pupae P8    9 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    7 head, mated 1-day male    8 head, mated 4-day male    10 head, mated 20-day male    11 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    10 digestive system, 4-day adult    14 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    8 fat body, pupae P8    9 carcass, larvae L3 wandering    15 carcass, 1-day adult    8 carcass, 4-day adult    11 carcass, 20-day adult    9 ovary, virgin 4-day female    64 ovary, mated 4-day female    61 testis, mated 4-day male    32 accessory gland, mated 4-day male    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    27 central nervous system, larvae L3    17 central nervous system, pupae P8    9 head, virgin 1-day female    7 head, virgin 4-day female    8 head, virgin 20-day female    8 head, mated 1-day female    8 head, mated 4-day female    9 head, mated 20-day female    7 head, mated 1-day male    8 head, mated 4-day male    10 head, mated 20-day male    11 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    6 digestive system, larvae L3 wandering    7 digestive system, 1-day adult    10 digestive system, 4-day adult    14 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    8 fat body, pupae P8    9 carcass, larvae L3 wandering    15 carcass, 1-day adult    8 carcass, 4-day adult    11 carcass, 20-day adult    9 ovary, virgin 4-day female    64 ovary, mated 4-day female    61 testis, mated 4-day male    32 accessory gland, mated 4-day male    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    105 embryo 02-04hr    100 embryo 04-06hr    45 embryo 06-08hr    49 embryo 08-10hr    58 embryo 10-12hr    55 embryo 12-14hr    37 embryo 14-16hr    46 embryo 16-18hr    31 embryo 18-20hr    21 embryo 20-22hr    29 embryo 22-24hr    26 larva L1    33 larva L2    21 larva L3 12hr old    17 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    17 white prepupae new    17 white prepupae 12hr    18 white prepupae 24hr    27 pupae 2d postWPP    25 pupae 3d postWPP    15 pupae 4d postWPP    19 adult male 01day    22 adult male 05day    30 adult male 30day    31 adult female 01day    53 adult female 05day    63 adult female 30day    68 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (105) embryo 02-04hr  (100) embryo 04-06hr  (45) embryo 06-08hr  (49) embryo 08-10hr  (58) embryo 10-12hr  (55) embryo 12-14hr  (37) embryo 14-16hr  (46) embryo 16-18hr  (31) embryo 18-20hr    21 embryo 20-22hr  (29) embryo 22-24hr  26 larva L1  (33) larva L2    21 larva L3 12hr old    17 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    17 white prepupae new    17 white prepupae 12hr    18 white prepupae 24hr  (27) pupae 2d postWPP    25 pupae 3d postWPP    15 pupae 4d postWPP    19 adult male 01day    22 adult male 05day  (30) adult male 30day  (31) adult female 01day  (53) adult female 05day  (63) adult female 30day  (68) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  105 embryo 02-04hr    100 embryo 04-06hr    45 embryo 06-08hr    49 embryo 08-10hr    58 embryo 10-12hr    55 embryo 12-14hr    37 embryo 14-16hr    46 embryo 16-18hr    31 embryo 18-20hr    21 embryo 20-22hr    29 embryo 22-24hr    26 larva L1    33 larva L2    21 larva L3 12hr old    17 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    17 white prepupae new    17 white prepupae 12hr    18 white prepupae 24hr    27 pupae 2d postWPP    25 pupae 3d postWPP    15 pupae 4d postWPP    19 adult male 01day    22 adult male 05day    30 adult male 30day    31 adult female 01day    53 adult female 05day    63 adult female 30day    68 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    105 embryo 02-04hr    100 embryo 04-06hr    45 embryo 06-08hr    49 embryo 08-10hr    58 embryo 10-12hr    55 embryo 12-14hr    37 embryo 14-16hr    46 embryo 16-18hr    31 embryo 18-20hr    21 embryo 20-22hr    29 embryo 22-24hr    26 larva L1    33 larva L2    21 larva L3 12hr old    17 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    17 white prepupae new    17 white prepupae 12hr    18 white prepupae 24hr    27 pupae 2d postWPP    25 pupae 3d postWPP    15 pupae 4d postWPP    19 adult male 01day    22 adult male 05day    30 adult male 30day    31 adult female 01day    53 adult female 05day    63 adult female 30day    68 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    105 embryo 02-04hr    100 embryo 04-06hr    45 embryo 06-08hr    49 embryo 08-10hr    58 embryo 10-12hr    55 embryo 12-14hr    37 embryo 14-16hr    46 embryo 16-18hr    31 embryo 18-20hr    21 embryo 20-22hr    29 embryo 22-24hr    26 larva L1    33 larva L2    21 larva L3 12hr old    17 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    17 white prepupae new    17 white prepupae 12hr    18 white prepupae 24hr    27 pupae 2d postWPP    25 pupae 3d postWPP    15 pupae 4d postWPP    19 adult male 01day    22 adult male 05day    30 adult male 30day    31 adult female 01day    53 adult female 05day    63 adult female 30day    68 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (105) embryo 02-04hr  (100) embryo 04-06hr  (45) embryo 06-08hr  (49) embryo 08-10hr  (58) embryo 10-12hr  (55) embryo 12-14hr  (37) embryo 14-16hr  (46) embryo 16-18hr  31 embryo 18-20hr    21 embryo 20-22hr  29 embryo 22-24hr  26 larva L1  (33) larva L2    21 larva L3 12hr old    17 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    17 white prepupae new    17 white prepupae 12hr    18 white prepupae 24hr  27 pupae 2d postWPP    25 pupae 3d postWPP    15 pupae 4d postWPP    19 adult male 01day    22 adult male 05day  30 adult male 30day  31 adult female 01day  (53) adult female 05day  (63) adult female 30day  (68) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  105 embryo 02-04hr    100 embryo 04-06hr    45 embryo 06-08hr    49 embryo 08-10hr    58 embryo 10-12hr    55 embryo 12-14hr    37 embryo 14-16hr    46 embryo 16-18hr    31 embryo 18-20hr    21 embryo 20-22hr    29 embryo 22-24hr    26 larva L1    33 larva L2    21 larva L3 12hr old    17 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    17 white prepupae new    17 white prepupae 12hr    18 white prepupae 24hr    27 pupae 2d postWPP    25 pupae 3d postWPP    15 pupae 4d postWPP    19 adult male 01day    22 adult male 05day    30 adult male 30day    31 adult female 01day    53 adult female 05day    63 adult female 30day    68 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    105 embryo 02-04hr    100 embryo 04-06hr    45 embryo 06-08hr    49 embryo 08-10hr    58 embryo 10-12hr    55 embryo 12-14hr    37 embryo 14-16hr    46 embryo 16-18hr    31 embryo 18-20hr    21 embryo 20-22hr    29 embryo 22-24hr    26 larva L1    33 larva L2    21 larva L3 12hr old    17 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    17 larva L3 puffstage 7-9    17 white prepupae new    17 white prepupae 12hr    18 white prepupae 24hr    27 pupae 2d postWPP    25 pupae 3d postWPP    15 pupae 4d postWPP    19 adult male 01day    22 adult male 05day    30 adult male 30day    31 adult female 01day    53 adult female 05day    63 adult female 30day    68 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    38 Schneider line 2 Sg4    57 embryonic 1182-4H    37 embryonic GM2    27 embryonic Kc167    95 embryonic S1    82 embryonic S3    31 leg disc CME L1    66 wing disc CME-W2    49 wing disc ML-DmD8    38 wing disc ML-DmD9    52 wing disc ML-DmD16-c3    183 wing disc ML-DmD21    73 wing disc ML-DmD32    77 haltere disc ML-DmD17-c3    34 eye-antennal disc ML-DmD11    71 antennal disc ML-DmD20-c5    54 mixed discs ML-DmD4-c1    37 CNS ML-DmBG1-c1    67 CNS ML-DmBG2-c2    41 tumorous blood cells mbn2    43 ovary fGS/OSS    46 ovary OSC    32 ovary OSS    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (38) Schneider line 2 Sg4  (57) embryonic 1182-4H  (37) embryonic GM2  (27) embryonic Kc167  (95) embryonic S1  (82) embryonic S3  (31) leg disc CME L1  (66) wing disc CME-W2  (49) wing disc ML-DmD8  (38) wing disc ML-DmD9  (52) wing disc ML-DmD16-c3  (183) wing disc ML-DmD21  (73) wing disc ML-DmD32  (77) haltere disc ML-DmD17-c3  (34) eye-antennal disc ML-DmD11  (71) antennal disc ML-DmD20-c5  (54) mixed discs ML-DmD4-c1  (37) CNS ML-DmBG1-c1  (67) CNS ML-DmBG2-c2  (41) tumorous blood cells mbn2  (43) ovary fGS/OSS  (46) ovary OSC  (32) ovary OSS    22 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    38 Schneider line 2 Sg4    57 embryonic 1182-4H    37 embryonic GM2    27 embryonic Kc167    95 embryonic S1    82 embryonic S3    31 leg disc CME L1    66 wing disc CME-W2    49 wing disc ML-DmD8    38 wing disc ML-DmD9    52 wing disc ML-DmD16-c3  (183) wing disc ML-DmD21    73 wing disc ML-DmD32    77 haltere disc ML-DmD17-c3    34 eye-antennal disc ML-DmD11    71 antennal disc ML-DmD20-c5    54 mixed discs ML-DmD4-c1    37 CNS ML-DmBG1-c1    67 CNS ML-DmBG2-c2    41 tumorous blood cells mbn2    43 ovary fGS/OSS    46 ovary OSC    32 ovary OSS    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    38 Schneider line 2 Sg4    57 embryonic 1182-4H    37 embryonic GM2    27 embryonic Kc167    95 embryonic S1    82 embryonic S3    31 leg disc CME L1    66 wing disc CME-W2    49 wing disc ML-DmD8    38 wing disc ML-DmD9    52 wing disc ML-DmD16-c3    183 wing disc ML-DmD21    73 wing disc ML-DmD32    77 haltere disc ML-DmD17-c3    34 eye-antennal disc ML-DmD11    71 antennal disc ML-DmD20-c5    54 mixed discs ML-DmD4-c1    37 CNS ML-DmBG1-c1    67 CNS ML-DmBG2-c2    41 tumorous blood cells mbn2    43 ovary fGS/OSS    46 ovary OSC    32 ovary OSS    22 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    38 Schneider line 2 Sg4    57 embryonic 1182-4H    37 embryonic GM2    27 embryonic Kc167    95 embryonic S1    82 embryonic S3    31 leg disc CME L1    66 wing disc CME-W2    49 wing disc ML-DmD8    38 wing disc ML-DmD9    52 wing disc ML-DmD16-c3    183 wing disc ML-DmD21    73 wing disc ML-DmD32    77 haltere disc ML-DmD17-c3    34 eye-antennal disc ML-DmD11    71 antennal disc ML-DmD20-c5    54 mixed discs ML-DmD4-c1    37 CNS ML-DmBG1-c1    67 CNS ML-DmBG2-c2    41 tumorous blood cells mbn2    43 ovary fGS/OSS    46 ovary OSC    32 ovary OSS    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (38) Schneider line 2 Sg4  (57) embryonic 1182-4H  (37) embryonic GM2  27 embryonic Kc167  (95) embryonic S1  (82) embryonic S3  31 leg disc CME L1  (66) wing disc CME-W2  (49) wing disc ML-DmD8  (38) wing disc ML-DmD9  (52) wing disc ML-DmD16-c3  (183) wing disc ML-DmD21  (73) wing disc ML-DmD32  (77) haltere disc ML-DmD17-c3  (34) eye-antennal disc ML-DmD11  (71) antennal disc ML-DmD20-c5  (54) mixed discs ML-DmD4-c1  (37) CNS ML-DmBG1-c1  (67) CNS ML-DmBG2-c2  (41) tumorous blood cells mbn2  (43) ovary fGS/OSS  (46) ovary OSC  32 ovary OSS    22 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    38 Schneider line 2 Sg4    57 embryonic 1182-4H    37 embryonic GM2    27 embryonic Kc167    95 embryonic S1    82 embryonic S3    31 leg disc CME L1    66 wing disc CME-W2    49 wing disc ML-DmD8    38 wing disc ML-DmD9    52 wing disc ML-DmD16-c3  (183) wing disc ML-DmD21    73 wing disc ML-DmD32    77 haltere disc ML-DmD17-c3    34 eye-antennal disc ML-DmD11    71 antennal disc ML-DmD20-c5    54 mixed discs ML-DmD4-c1    37 CNS ML-DmBG1-c1    67 CNS ML-DmBG2-c2    41 tumorous blood cells mbn2    43 ovary fGS/OSS    46 ovary OSC    32 ovary OSS    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    38 Schneider line 2 Sg4    57 embryonic 1182-4H    37 embryonic GM2    27 embryonic Kc167    95 embryonic S1    82 embryonic S3    31 leg disc CME L1    66 wing disc CME-W2    49 wing disc ML-DmD8    38 wing disc ML-DmD9    52 wing disc ML-DmD16-c3    183 wing disc ML-DmD21    73 wing disc ML-DmD32    77 haltere disc ML-DmD17-c3    34 eye-antennal disc ML-DmD11    71 antennal disc ML-DmD20-c5    54 mixed discs ML-DmD4-c1    37 CNS ML-DmBG1-c1    67 CNS ML-DmBG2-c2    41 tumorous blood cells mbn2    43 ovary fGS/OSS    46 ovary OSC    32 ovary OSS    22 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    12 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult    51 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    31 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    43 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult    35 Paraquat 10 mM 48 hrs, 4-day adult    39 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    12 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult  (51) Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult  (31) Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3  (43) Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (37) Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult  (35) Paraquat 10 mM 48 hrs, 4-day adult  (39) Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    12 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult    51 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    31 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    43 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult    35 Paraquat 10 mM 48 hrs, 4-day adult    39 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    12 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult    51 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    31 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    43 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult    35 Paraquat 10 mM 48 hrs, 4-day adult    39 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    12 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult    51 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    31 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    43 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult    35 Paraquat 10 mM 48 hrs, 4-day adult    39 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    12 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult  (51) Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult  31 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3  (43) Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (37) Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult  (35) Paraquat 10 mM 48 hrs, 4-day adult  (39) Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    12 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult    51 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    31 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    43 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult    35 Paraquat 10 mM 48 hrs, 4-day adult    39 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    16 cold shock, 4-day adult    12 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    10 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    22 Cadmium 100 mM 48 hrs, 4-day adult    51 Copper 0.5 mM 12 hrs, larvae L3    11 Copper 15 mM 48 hrs, 4-day adult    31 Zinc 5 mM 12 hrs, larvae L3    8 Zinc 4.5 mM 48 hrs, 4-day adult    18 Ethanol 2.5% 3 hrs, larvae L3    43 Ethanol 5% 3 hrs, larvae L3    6 Ethanol 10% 3 hrs, larvae L3    8 Caffeine 1.5 mg/ml 4 hrs, larvae L3    7 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    37 Caffeine 25 mg/ml 48 hrs, 4-day adult    19 Paraquat 5 mM 48 hrs, 4-day adult    35 Paraquat 10 mM 48 hrs, 4-day adult    39 Rotenone 2 μg 12 hrs, larvae L3    9 Rotenone 8 μg 12 hrs, larvae L3    10 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_01 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • LD22726 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001978 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3647-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | maternal effect | recessive stc3 lethal | embryonic stage | recessive stc3 stc05441 lethal | recessive stc1 stc05441 stck11112 stcSH1565 stcunspecified viable, with Scer\GAL4pnr-MD237 stcGD1543 Other Phenotypes Allele short lived | female limited stcKG01230 Phenotype manifest in Allele abdominal segmental nerve stc3 abdominal segmental nerve | embryonic stage | maternal effect stc3 central nervous system stc3 denticle belt | maternal effect stc3 embryonic/first instar larval cuticle | maternal effect stc3 intersegmental nerve stc3 intersegmental nerve | embryonic stage | maternal effect stc3 presumptive embryonic/larval central nervous system | maternal effect stc3 ventral nerve cord & abdominal segment 4 | maternal effect stc3 ventral nerve cord & abdominal segment 5 | maternal effect stc3 ventral nerve cord & abdominal segment 6 | maternal effect stc3 ventral nerve cord & abdominal segment 7 | maternal effect stc3 ventral nerve cord & abdominal segment 8 | maternal effect stc3 ventral nerve cord | maternal effect stc3
Classical Alleles ( 13 )
For All Classical Alleles Show
Allele of stc Class Mutagen Stocks Known lesion stc05441 loss of function allele P-element activity 2 Yes stc3 loss of function allele ethyl methanesulfonate 1 -- stc6 X ray gamma ray 1 -- stcKG01230 1 -- stc1 ethyl methanesulfonate 0 -- stc2 ethyl methanesulfonate 0 -- stc4 ethyl methanesulfonate 0 -- stc5 ethyl methanesulfonate 0 -- stck11112 P-element activity 0 -- stcNP3113 0 -- stcSH1565 P-element activity 0 -- stcTE35D-4 0 -- stcunspecified 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of stc Class Mutagen Stocks Known lesion stcGD1543 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes stcGL01553 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)A48 (Spradling et al., 1999, Cai et al., 2001, Ashburner et al., 1982, Ashburner et al., 1982, Fossett et al., 1994, Grau et al., 1984) Df(2L)A72 (Ashburner et al., 1982, Ashburner et al., 1982, Ashburner et al., 1990, Fossett et al., 1994, Roote et al., 1996) Df(2L)A215 (Ashburner et al., 1982, Fossett et al., 1994) Df(2L)A220 (Ashburner et al., 1982, Fossett et al., 1994, Roote et al., 1996) Df(2L)A246 (Ashburner et al., 1982, Fossett et al., 1994) Df(2L)A263 (Ashburner et al., 1982, Furukawa et al., 1992) Df(2L)A264 (Ashburner et al., 1982, Fossett et al., 1994) Df(2L)A337 (Fossett et al., 1994) Df(2L)A376 (Ashburner et al., 1982, Ashburner, 1982, Fossett et al., 1994) Df(2L)A377 (Ashburner et al., 1982, Ashburner, 1982) Df(2L)A400 (Ashburner et al., 1982, Ashburner, 1982, Fossett et al., 1994, Roote et al., 1996) Df(2L)Adh-nBR55 (Roote, 1995.3.24) Df(2L)Adh-nBR101 (Fossett et al., 1994) Df(2L)Adh-nBR102 (Fossett et al., 1994) Df(2L)Adh-nBR103 (Fossett et al., 1994) Df(2L)Adh-nBR105 (Fossett et al., 1994, Roote, 1996.1.11, Roote et al., 1996, Roote, 1996.8) Df(2L)Adh-nBR118 (Fossett et al., 1994) Df(2L)Adh-nBR120 (Fossett et al., 1994) Df(2L)Adh-nBR122 (Fossett et al., 1994, Roote, 1996.1.11, Roote et al., 1996, Roote, 1996.8) Df(2L)Adh-nBR125 (Fossett et al., 1994) Df(2L)Adh-nBR126 (Fossett et al., 1994) Df(2L)Adh-nBR128 (Fossett et al., 1994, Roote, 1996.1.11, Roote et al., 1996, Roote, 1996.8) Df(2L)Adh-nBR129 (Fossett et al., 1994) Df(2L)Adh-nBR130 (Fossett et al., 1994) Df(2L)Adh-nBR131 (Fossett et al., 1994, Roote, 1996.1.11, Roote, 1996.8) Df(2L)b80e4 (Ashburner et al., 1990) Df(2L)b84h50 (Furukawa et al., 1992, Roote, 1996.8) Df(2L)b88c58 (Alexandrov and Alexandrova, 1991, Roote, 1996.8) Df(2L)do1 (Ashburner, 1982) Df(2L)ED1050 (Roote, 2004.6.24) Df(2L)el20 (Ashburner et al., 1990) Df(2L)el28 (Ashburner et al., 1990, Furukawa et al., 1992) Df(2L)el80f1 (Ashburner et al., 1983) Df(2L)Exel7062 (Ryder, 2004.4.26) Df(2L)fn1 (Ashburner et al., 1982, Ashburner et al., 1982, Grau et al., 1984) Df(2L)fn5 (Ashburner et al., 1982, Furukawa et al., 1992) Df(2L)fn26 (Ashburner et al., 1982, Ashburner et al., 1990) Df(2L)fn27 (Ashburner et al., 1982, Ashburner et al., 1982, Ashburner, 1982, Ashburner et al., 1990) Df(2L)k05007-mr19 (Roote, 2000.6.13) Df(2L)k09033-mr19 (Roote, 2000.6.13) Df(2L)n78l3 (Ashburner et al., 1982, Ashburner et al., 1990) Df(2L)nNxF1 (Roote et al., 1996, Roote, 1996.8) Df(2L)nNxF2 (Roote et al., 1996) Df(2L)noc11 (Ashburner et al., 1990) Df(2L)osp29 (Cai et al., 2001, Ashburner et al., 1982, Furukawa et al., 1992, Grau et al., 1984) Df(2L)osp38 (Ashburner et al., 1990) Df(2L)Sco7 (Ashburner et al., 1983, Ashburner et al., 1990) Df(2L)Scorv4 (Ashburner et al., 1983, Ashburner et al., 1990, Roote et al., 1996) Df(2L)Scorv23 (Ashburner, 1982, Ashburner et al., 1983, Grau et al., 1984) Df(2L)TE35B-1 (Gubb et al., 1985) Df(2L)TE35B-2 (Gubb et al., 1985) Df(2L)TE35B-5 (Gubb et al., 1985, Roote, 1996.8) Df(2L)TE35B-6 (Gubb et al., 1985, Roote et al., 1996) Df(2L)TE35BC-3 (Cai et al., 2001, Ashburner et al., 1982, Ashburner, 1982, Gubb et al., 1984, Ashburner et al., 1990, Grau et al., 1984) Df(2L)TE35BC-4 (Ashburner et al., 1982, Ashburner, 1982, Gubb et al., 1984, Ashburner et al., 1990) Df(2L)TE35BC-6 (Gubb et al., 1984) Df(2L)TE35BC-8 (Gubb et al., 1984) Df(2L)TE35BC-24 (Gubb et al., 1984, Zhu et al., 2005) Df(2L)TE35BC-34 (Gubb et al., 1984, Ashburner et al., 1990) Df(2L)TE35BC-35 (Gubb et al., 1984) Df(2L)TE35D-4 (Ashburner et al., 1990, Stroumbakis et al., 1996, Roote, 1997.6.6) Df(2L)TE35D-16 (Ashburner et al., 1990) Df(2L)TE35D-18 (Furukawa et al., 1992) Df(2L)TE35D-20 (Ashburner et al., 1990) Df(2L)TE35D-23 (Ashburner et al., 1990) In(2L)75c (Ashburner, 1982, Grau et al., 1984) In(2L)C158LScorv11R (Ashburner et al., 1983, Ashburner and Harrington, 1984) In(2L)C158LScorv17R (Ashburner et al., 1983, Ashburner and Harrington, 1984) In(2L)dpps22Ldppd36R (Ashburner et al., 1990) In(2L)el18 (Ashburner et al., 1990) In(2L)TE35B-13 (Gubb et al., 1985) In(2LR)noc4LScorv9R (Cai et al., 2001, Ashburner and Harrington, 1984) In(2LR)pkD1-rv8 (Roote, 1997.6.6) In(2LR)TE35B-6LScorv9R (Ashburner and Harrington, 1984) Tp(2;2)A446 (Ashburner et al., 1982, Ashburner et al., 1982, Fossett et al., 1994) Ts(2Lt;3Lt)TE35B-4+Ts(2Rt;3Rt)Scorv13 (Ashburner and Harrington, 1984) Ts(2Lt;3Lt)TE35BC-3+Ts(2Rt;3Rt)Scorv13 (Ashburner et al., 1983, Ashburner and Harrington, 1984)
Partially disrupted in	Df(2L)Scorv4 (Ashburner et al., 1999.10.12)
Not disrupted in	Df(2L)64j (Ashburner, 1982, Ashburner et al., 1990, Furukawa et al., 1992) Df(2L)A47 (Ashburner et al., 1982, Fossett et al., 1994) Df(2L)A63 (Ashburner et al., 1982, Ashburner et al., 1982, Fossett et al., 1994) Df(2L)A178 (Ashburner et al., 1982, Ashburner et al., 1982, Fossett et al., 1994) Df(2L)A217 (Ashburner et al., 1982, Fossett et al., 1994) Df(2L)A245 (Ashburner et al., 1982, Fossett et al., 1994) Df(2L)A260 (Ashburner et al., 1982) Df(2L)A266 (Ashburner et al., 1982, Ashburner et al., 1982, Fossett et al., 1994) Df(2L)A267 (Ashburner et al., 1982, Ashburner et al., 1982, Lasko and Ashburner, 1988, Ashburner et al., 1990, Fossett et al., 1994) Df(2L)A379 (Ashburner et al., 1982, Ashburner et al., 1982, Fossett et al., 1994) Df(2L)A400 (Ashburner et al., 1982) Df(2L)A445 (Ashburner et al., 1982, Fossett et al., 1994) Df(2L)Adh-nBR100 (Fossett et al., 1994) Df(2L)Adh-nBR106 (Fossett et al., 1994) Df(2L)Adh-nBR107 (Fossett et al., 1994) Df(2L)Adh-nBR117 (Fossett et al., 1994) Df(2L)Adh-nBR119 (Fossett et al., 1994) Df(2L)Adh-nBR121 (Fossett et al., 1994) Df(2L)Adh-nBR127 (Fossett et al., 1994) Df(2L)ARR1 (Ashburner, 1982, Ashburner et al., 1990, Furukawa et al., 1992) Df(2L)b80e3 (Ashburner et al., 1982) Df(2L)b81a1 (Ashburner et al., 1982) Df(2L)b84a3 (Furukawa et al., 1992) Df(2L)b84a7 (Furukawa et al., 1992) Df(2L)b87e25 (Roote, 1996.8, Zhu et al., 2005) Df(2L)b89e80a (Roote, 2000.7.3) Df(2L)fn2 (Ashburner et al., 1982, Ashburner et al., 1982, Grau et al., 1984) Df(2L)fn3 (Ashburner et al., 1982, Ashburner, 1982) Df(2L)fn7 (Ashburner et al., 1982, Ashburner, 1982) Df(2L)fn12 (Ashburner et al., 1982, Ashburner et al., 1990) Df(2L)fn15 (Ashburner et al., 1982) Df(2L)fn30 (Ashburner et al., 1982) Df(2L)fn31 (Ashburner et al., 1982, Ashburner, 1982) Df(2L)fn36 (Ashburner et al., 1982) Df(2L)H20 (Ashburner et al., 1990) Df(2L)osp144 (Ashburner et al., 1982) Df(2L)PA4 (Ashburner et al., 1983) Df(2L)PZ07130-mr2 (Roote, 2000.6.13) Df(2L)PZ07130-mr7 (Roote, 2000.6.13) Df(2L)r10 (Ashburner et al., 1990, Zhu et al., 2005) Df(2L)RA5 (Ashburner et al., 1990) Df(2L)rd9 (Ashburner et al., 1990, Furukawa et al., 1992, Roote, 1996.8, Zhu et al., 2005) Df(2L)RM5 (Ashburner et al., 1990) Df(2L)RN2 (Ashburner et al., 1990) Df(2L)Sco-1 (Ashburner, 1982) Df(2L)Scorv10 (Ashburner et al., 1983, Grau et al., 1984) Df(2L)Scorv14 (Ashburner et al., 1983) Df(2L)Scorv16 (Ashburner et al., 1983, Ashburner et al., 1990, Grau et al., 1984) Df(2L)Scorv18 (Ashburner et al., 1983, Ashburner et al., 1990) Df(2L)Scorv19 (Ashburner et al., 1983, Ashburner et al., 1990, Grau et al., 1984) Df(2L)Scorv25 (Ashburner et al., 1983, Ashburner et al., 1990, Grau et al., 1984) Df(2L)SS1 (Ashburner et al., 1990, Grau et al., 1984) Df(2L)TE35B-3 (Gubb et al., 1985) Df(2L)TE35B-4 (Gubb et al., 1985) Df(2L)TE35B-5 (Lasko and Ashburner, 1988) Df(2L)TE35B-7 (Gubb et al., 1985) Df(2L)TE35B-8 (Gubb et al., 1985) Df(2L)TE35B-9 (Gubb et al., 1985) Df(2L)TE35B-10 (Gubb et al., 1985) Df(2L)TE35B-11 (Gubb et al., 1985) Df(2L)TE35B-12 (Gubb et al., 1985) Df(2L)TE35B-15 (Gubb et al., 1985) Df(2L)TE35BC-1 (Ashburner, 1982, Gubb et al., 1984) Df(2L)TE35BC-7 (Gubb et al., 1984, Furukawa et al., 1992) Df(2L)TE35BC-23 (Gubb et al., 1984) Df(2L)TE35BC-28 (Gubb et al., 1984, Furukawa et al., 1992) Df(2L)TE35BC-29 (Gubb et al., 1984) Df(2L)TE35BC-31 (Gubb et al., 1984) Df(2L)TE35D-1 (Ashburner et al., 1990) Df(2L)TE35D-2 (Ashburner et al., 1990, Furukawa et al., 1992) Df(2L)TE35D-3 (Ashburner et al., 1990) Df(2L)TE35D-6 (Ashburner et al., 1990, Furukawa et al., 1992, Stroumbakis et al., 1996) Df(2L)TE35D-13 (Ashburner et al., 1990, Furukawa et al., 1992) Df(2L)TE35D-14 (Ashburner et al., 1990) Df(2L)TE35D-15 (Ashburner et al., 1990, Furukawa et al., 1992) Df(2L)TE35D-19 (Ashburner et al., 1990) Df(2L)TE35D-21 (Ashburner et al., 1990) Df(2L)TE35D-22 (Cai et al., 2001, Ashburner et al., 1990) Df(2L)W (Ashburner et al., 1982) In(2LR)Scorv1-DV7 (Ashburner et al., 1990) T(2;3)Scorv7 (Ashburner et al., 1983, Ashburner and Harrington, 1984, Ashburner et al., 1990, Grau et al., 1984) T(Y;2)A80DR15P (Ashburner et al., 1982) Ts(Y;2Lt)el4+Ts(YSt;2Rt)R15 (Ashburner et al., 1982)
Duplicated in	Dp(2;1)Scorv23 (Ashburner, 1982, Ashburner et al., 1983, Ashburner et al., 1990, Grau et al., 1984) Dp(2;2)GYL (Ashburner, 1982, Ashburner et al., 1990) Dp(2;2)GYS (Ashburner, 1982) Dp(2;2)TE35B-54L (Ashburner et al., 1990) Dp(2;3)osp3 (Ashburner et al., 1990) In(2L)C163.41LC158R (Ashburner, 1982, Ashburner et al., 1990) In(2L)Scorv17LC158R (Ashburner, 1982, Ashburner et al., 1990)
Not duplicated in	Dp(2;2)Adh3 (Ashburner, 1982)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1543} NA P{TRiP.GL01553} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}k11112 No P{PZ}stc05441 No insertion of enhancer trap binary system P{GawB}stcNP3113 No miscellaneous insertions P{SUPor-P}stcKG01230 NA
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Stroumbakis et al., 1996)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
nucleic acid binding inferred from electronic annotation with InterPro:IPR001374 (FlyBase Curators et al., 2004-) sequence-specific DNA binding transcription factor activity inferred from sequence or structural similarity with human NFX1 (Stroumbakis et al., 1996) single-stranded DNA binding non-traceable author statement (Tolias, 1994.4.29) zinc ion binding inferred from electronic annotation with InterPro:IPR000967, InterPro:IPR001841 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
nervous system development non-traceable author statement (Swiss-Prot Project Members, 1995.2.1) regulation of transcription, DNA-dependent inferred from electronic annotation with InterPro:IPR000967 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Ashburner et al., 1999)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity (Ashburner et al., 1999) non-traceable author statement (Swiss-Prot Project Members, 1995.2.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
stc - Gadd34 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions stc allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60906 DroID - A comprehensive database of gene and protein interactions. • FBgn0001978 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34888
Orthologs
OrthoDB Orthologs (37) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG644M4N Dipteran inclusive ortholog search EOG6894VH Insect inclusive ortholog search EOG6HX3VW Arthropod inclusive ortholog search EOG67D7WX Metazoa inclusive ortholog search EOG6064SQ
Orthologs in Drosophila Species (EOG644M4N)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\stc     Drosophila simulans   Dsim\GD23996 Y   Drosophila sechellia   Dsec\GM15949 Y   Drosophila erecta   Dere\GG25149 Y   Drosophila yakuba   Dyak\GE20891 Y   Drosophila ananassae   Dana\GF14341 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA17585 Y   Drosophila persimilis   Dper\GL26033 Y   Drosophila willistoni   Dwil\GK18317 Y   Drosophila virilis   Dvir\GJ11954 Y   Drosophila mojavensis   Dmoj\GI13324 Y   Drosophila grimshawi   Dgri\GH10921 Y
Orthologs in non-Drosophila Dipterans (EOG6894VH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL001636   Anopheles gambiae Malaria mosquito  Agam\AGAP008728   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ000861
Orthologs in non-Dipteran Insects (EOG6HX3VW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB54378   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG022091   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH10450   Atta cephalotes Leafcutter ant  Acep\ACEP23349   Camponotus floridanus Florida carpenter ant  Cflo\CFLO13853   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19741   Linepithema humile Argentine ant  Lhum\LH18434   Pogonomyrmex barbatus Red harvester ant  Pbar\PB11459   Solenopsis invicta Red fire ant  Sinv\SINV23286   Acyrthosiphon pisum Pea aphid  Apim\ACYPI000420   Bombyx mori Silkmoth  Bmor\BGIBMGA005634   Pediculus humanus Human body louse  Phum\PHUM136550   Tribolium castaneum Red flour beetle  Tcas\TC030607
Orthologs in non-Insect Arthropods (EOG67D7WX)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_307023   Ixodes scapularis Deer tick  Isca\ISCW024451
Orthologs in non-Arthropod Metazoa (EOG6064SQ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\tag-182   Danio rerio Zebrafish  Drer\ENSDARG00000076662   Xenopus tropicalis Western clawed frog  Xtro\nfx1   Gallus gallus Domestic chicken  Ggal\NFX1   Mus musculus House mouse  Mmus\Nfx1   Rattus norvegicus Norway rat  Rnor\Nfx1   Homo sapiens Human  Hsap\NFX1
Human Orthologs (1)
Gene OMIM HGNC Hsap\NFX1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD23996 Drosophila sechellia Dsec\GM15949 Drosophila erecta Dere\GG25149 Drosophila yakuba Dyak\GE20891 Drosophila ananassae Dana\GF14341 Drosophila pseudoobscura pseudoobscura Dpse\GA17585 Drosophila persimilis Dper\GL26033 Drosophila willistoni Dwil\GK18317 Drosophila virilis Dvir\GJ11954 Drosophila mojavensis Dmoj\GI13324 Drosophila grimshawi Dgri\GH10921
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	25139 In(2L)dpps22, dpps22 stc6/CyO 13413 y1 w67c23; P{SUPor-P}stcKG01230 43208 y1 sc* v1; P{TRiP.GL01553}attP40 30472 b1 stc3 pr1 cn1 bw1/SM5 11408 P{PZ}stc05441 CG1526905441 cn1/CyO; ry506
Kyoto	130377 P{PZ}stc05441 cn1 / CyO; ry506
VDRC	v47973 w1118; P{GD1543}v47973 v47974 w1118; P{GD1543}v47974/TM3
Genomic Clones ( 1 )
	BACR06I01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 110 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT25289 LD22726
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT08578 AT08728 AT09157 AT11238 AT12669 AT21280 AT28181 AT31526 LD02285 LD08763 LD09946 LD25467 LD25490 LD27525 LD29364 LD32773 RE04892 RE12650 RE14203 RE14274 RE20117 RE20351 RE23747 RE23926 RE25107 RE31215 RE32561 RE33195 RE34693 RE39190 RE46378 RE58739 SD21913 SD26353 SD28018
Other clones	69283 100528 101856 190172 534040 AT11720 CK01.87A.C8 CK01.94A.D12 Dmel_dig_004627_0708_3437 Dmel_dig_010725_0591_3538 Dmel_neb_012942_0895_0357 EK068644 EK073346 EK196351 EK223152 EK228625 EK231907 EK259906 EK291332 EN10123 FGC024D01 IP04829 RP003011018 RP003031438 RP003038185 RP003042157 RP003086584 RP003093418 RP003100914 RP003102612 RP003114838 RP003118021 RP003118589 RP003125414 RP003130471 RP003131067 RP003143030 RP003149048 RP003197269 RP003218886 RP003237466 RP003260931 RP003262067 RP003278207 RP003281995 RP003292190 RP003296076 RP003298697 RP003302383 RP003302440 RP003318805 RP003321041 RP003328666 RP003333502 RP003338693 RP003339399 RP003339405 RP003351126 RP003351875 RP003352349 RP003360275 RP003388348 RP003388535 RP003405891 RP003438684 RP003451279 RP003473640 RP003474099 RP003493135 RP003560015 RP003618648 RP003650188 RP003673208
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0001978 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34888
Antibody Information
	polyclonal (Stroumbakis et al., 1996)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: stc CG3647 (Kodira, 1999.11)
Source for database merge of	Source for merge of: stc BcDNA:LD22726 (FlyBase, 1996-) Source for merge of: stc l(2)SH1565 (Roote, 2005.1.24)
Additional comments	Source for merge of stc BcDNA:LD22726 was sequence comparison (date:990717). (FlyBase, 1996-)
Other Comments
	Expression is enriched in embryonic gonads. (Shigenobu et al., 2006) 0 alleles of stc recovered in a P-insertion screen. (Oh et al., 2003) A maternally derived source of stc protein is required during embryogenesis but not oogenesis. (Tolias and Stroumbakis, 1998) FlyBase curator comment: Authors state "stc is the sole transcription unit in this region". Subsequent genome annotation identified adjacent CG15269, in which the 05441 insertion FBti0005150 identified with stc05441 (FBal0008509) maps. (Stroumbakis et al., 1996) Mutants fail to coordinate the contractions required for hatching and die during late embryogenesis. (Stroumbakis et al., 1995) 5 additional alleles are discussed but are not named. (Ashburner et al., 1990)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057250 NM_057251 NM_001273531 NM_001273532 RefSeq (Proteins) • NP_476598 NP_476599 NP_001260460 NP_001260461 DDBJ / EMBL / GenBank • AA202170 AA390475 AA390501 AA391078 AA820112 AA941360 AA941373 AA948858 AA952254 AA978739 AAB60255 AAD38654 AAF44922 AAF53441 AAN10891 AB082587 AE003412 AF145679 AGB92995 AGB92996 AI455296 G00414 U09306 Entrez Gene - A searchable database of RefSeq genes. • 34888 UniProtKB/Swiss-Prot • P40798
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, NF-X1-type (IPR000967) Single-stranded nucleic acid binding R3H (IPR001374) Zinc finger, RING-type (IPR001841) Zinc finger, PHD-type, conserved site (IPR019786) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD22726
Linkouts
	BioGRID - A database of protein and genetic interactions • 60906 DroID - A comprehensive database of gene and protein interactions. • FBgn0001978 DRSC - Results from RNAi screens. • FBgn0001978 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001978 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3647-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0001978 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34888 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /dbzhnsky/shtlcrf1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34888 modMine - Data generated by the modENCODE project. • FBgn0001978
Synonyms & Secondary IDs ( 18 )
Reported As
Symbol Synonym	151662_s_at (Kristensen et al., 2005) BcDNA:LD22726   BcDNA.LD22726 (Rubin, 1999.4.23) BG:DS04929.4 (Ashburner et al., 1999.10.12, Ashburner et al., 1999) br33 (Grau et al., 1984, Furukawa et al., 1992, Gubb et al., 1985, Ashburner and Harrington, 1984) Cf4   CG3647 (Whitfield, 2000.5.3, Wirbelauer et al., 2005, Bell et al., 2007, Ni et al., 2010.12.1) l35Cb (Fossett et al., 1994) l(2)35Cb (Ashburner et al., 1999, The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Alexandrova et al., 1996, Roote, 1995.5.15, Roote, 1995.5.4, Lindsley and Zimm, 1992, Ashburner et al., 1990) l(2)br33 (Gubb et al., 1984, Ashburner et al., 1983, Ashburner, 1982, Ashburner et al., 1982, Ashburner et al., 1982, ) l(2)SH2 1565 (Oh et al., 2002.3.26) l(2)SH1565   LD22726 (Pilot et al., 2006) stc (Jordan et al., 2006, Roote, 2005.1.24, Shigenobu et al., 2006, Negre et al., 2006, Zhu et al., 2005, Roshina et al., 2008, Weake et al., 2011, Pasyukova et al., 2004, Salzer et al., 2010, Gerhold et al., 2011)
Name Synonym	Chorion-factor-4   shuttle craft (Negre et al., 2006, Roshina et al., 2008, Pasyukova et al., 2004, Harbison et al., 2005, Salzer et al., 2010) shuttlecraft (Jordan et al., 2006, Gerhold et al., 2011) SHUTTLECRAFT (Boucher et al., 2001)
Secondary FlyBase IDs
	FBgn0065412
References ( 94 )
Generate a list of	All references relating to this gene ( 94 )
List References by type	Research paper  ( 42 ) Supplementary material  ( 8 ) Review  ( 2 ) Personal communication to FlyBase  ( 23 ) Abstract  ( 6 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 3 ) Stock list  ( 1 ) Book  ( 1 ) Curated genome annotation  ( 3 ) Protein sequence record  ( 1 ) Website  ( 1 )
Recent research papers ( 4 )
	Gabilondo et al., 2011, Mech. Dev. 128(3-4): 208--221 A targeted genetic screen identifies crucial players in the specification of the Drosophila abdominal Capaergic neurons. [FBrf0213290] Gerhold et al., 2011, Genetics 189(4): 1309--1326 Identification and characterization of genes required for compensatory growth in Drosophila. [FBrf0217000] Quan et al., 2011, Nat. Biotechnol. 29(5): 449--452 Parallel on-chip gene synthesis and application to optimization of protein expression. [FBrf0213642] Weake et al., 2011, Genes Dev. 25(14): 1499--1509 Post-transcription initiation function of the ubiquitous SAGA complex in tissue-specific gene activation. [FBrf0214372] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...