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Gene Dmel\Gli

General Information
Symbol	Dmel\Gli	Species	D. melanogaster
Name	Gliotactin	Annotation symbol	CG3903
Feature type	protein_coding_gene	FlyBase ID	FBgn0001987
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	l(2)35Dg, BG:DS09217.3, l(2)br45
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	35D4-35D4	Sequence location	2L:15,756,001..15,762,755 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Gliotactin is referred to in FlyBase by the symbol Dmel\Gli (CG3903, FBgn0001987). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: carboxylesterase activity. There is experimental evidence that it is involved in the biological process: synaptic target recognition; female meiosis chromosome segregation; maintenance of imaginal disc-derived wing hair orientation; border follicle cell migration; establishment of blood-nerve barrier; regulation of tube size, open tracheal system; septate junction assembly. 47 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; organ system; peripheral nervous system; adult segment; thoracic segment; eo support cell; apical junction complex; multicellular structure; sense organ; septate junction. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Carboxylesterase type B, conserved site; Carboxylesterase, type B. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 06-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval trachea. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, larval/adult hindgut, larval/adult salivary gland, adult spermathecae, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1624203_s_at completely aligns to an exonic region common to each of the 5 FlyBase-annotated transcript isoforms of Gli. Gene sequence location is 2L:15756001..15762755.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02	Controlled Vocabulary Terms synapse assembly cell surface neurexin family protein binding integral to plasma membrane receptor activity synapse
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 35D4-35D4   Limits computationally determined from genome sequence between P{lacW}CycEk05007&P{lacW}CycEk02602 and P{EP}crpEP721&P{lacW}crpk07829
Experimentally Determined Cytological Location
Cytogenetic map Notes References 35D7-35D7   (determined by in situ hybridisation)   (Abdelilah-Seyfried et al., 2000) 35D6-35D7   (determined by in situ hybridisation)   (Ashburner et al., 1999) 35D6-35D7   (determined by in situ hybridisation)   (Spradling et al., 1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes	l(2)35Di, l(2)35Df and Gli are definitely distal of wek. (Roote, 2000.6.13)
Gene Model & Products
Please see the GBrowse view of Dmel\Gli for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Gli-RA FBtr0080765  NM_057254   4093   956 Gli-RB FBtr0080766  NM_165130   3787   806 Gli-RC FBtr0080767  NM_165127   4184   956 Gli-RD FBtr0080768  NM_165128   3973   956 Gli-RE FBtr0080769  NM_165129   4008   956
Additional Transcript Data & Comments
Reported size (kB)	6.0 (northern blot) (Auld et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Gli-PA   FBpp0080324   109.2   956   8.79     NP_476602   AAF53482 Gli-PB   FBpp0080325   91.5   806   8.12     NP_723931   AAN10913 Gli-PC   FBpp0080326   109.2   956   8.79     NP_723928   AAN10910 Gli-PD   FBpp0080327   109.2   956   8.79     NP_723929   AAN10911 Gli-PE   FBpp0080328   109.2   956   8.79     NP_723930   AAN10912
Additional Polypeptide Data & Comments
Reported size (kDa)	956 (aa); 109 (kD predicted) (Auld et al., 1995)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Carboxylesterase, type B (IPR002018) Carboxylesterase type B, conserved site (IPR019819)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF53482   AE014134 AAN10910   AE014134 AAN10911   AE014134 AAN10912   AE014134 AAN10913   AE003414 AAF44964   AQ025882   AQ073477   AQ073491   AQ073569   AQ073609   AQ073729   BI161500   BI164283   BI165431   BI167781   BI172989   BI215238   BI228183   BI229356   BI232443   BI233261   BI234570   BI236159   BI236239   BI238686   BI240370   BI240419   BI356046   BI358595   BI363412   BI368755   BT004892 AAO47870   BT010017 AAQ22486   BT133203   CL868502   CO178278   CO189807   CO190197   CO264559   CO265165   CO265812   CO268736   CO269835   CO273508   CO274641   CO278800   CO280283   CO282704   CO284503   CO284639   CO285442   CO288072   CO289335   CO290720   CO292789   CO294968   CO303206   CO308305   CO314056   CO315891   CO318935   CO320050   CO326283   CO330683   CO334009   DN153964   DN154188   EC058927   EC061307   EC061399   EC069078   EC074830   EC077670   EC082640   EC084324   EC085679   EC086615   EC087007   EC088212   EC089994   EC090373   EC196338   EC199073   EC203939   EC210715   EC216519   EC218243   EC221281   EC231620   EC231869   EC232477   EC232639   EC234567   EC237621   EC242009   EC245484   EC250406   ES696489   ES696490   ES696493   GH942827   GH947924   GH948610   GH949216   GH954746   GH954948   GH956068   GH963810   GH964142   GH973704   GH974271   GH974302   GH976730   GH980511   GH982487   GH983045   GH984740   L39083 AAC41579   Z50443
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KT70 Q8IP36 Q7YU32 Q86LF3 Q9NK80
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   peripheral glial cell   (Auld et al., 1995) midline glial cell   (Auld et al., 1995) exit glial cell   (Auld et al., 1995) embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   hindgut anlage   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   antennal primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal ectoderm   (Fisher et al., 2012) inclusive hindgut primordium   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 11 -- 12   central brain primordium   (Fisher et al., 2012) dorsal epidermis primordium   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) somatic muscle primordium   (Fisher et al., 2012) tracheal primordium   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral epidermis primordium   (Fisher et al., 2012) embryonic stage 12   epidermis   (Auld et al., 1995) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic dorsal epidermis   (Fisher et al., 2012) embryonic foregut   (Fisher et al., 2012) embryonic head epidermis   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic ventral epidermis   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) embryonic/larval somatic muscle   (Fisher et al., 2012) lateral cord surface glial cell   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) sensory nervous system primordium   (Fisher et al., 2012) ventral midline   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
	Gli transcripts are expressed in most peripheral glia, in some exit glia, and in a number of midline glia. Prior to glial staining, there is some epidermal staining in broad, diffuse stripes at early stage 12. (Auld et al., 1995)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage   exit glial cell   (Auld et al., 1995) midline glial cell   (Auld et al., 1995) embryonic/larval hindgut   (Auld et al., 1995) intersegmental nerve   (Auld et al., 1995) segmental nerve   (Auld et al., 1995) embryonic stage 12   epidermis   (Auld et al., 1995) embryonic stage 13 -- 14   embryonic/larval trachea   (Auld et al., 1995) embryonic stage 13 -- 17   peripheral glial cell   (Auld et al., 1995) larval stage   peripheral nervous system   (Auld et al., 1995) ventral thoracic disc   (Auld et al., 1995) eye-antennal disc   (Auld et al., 1995) embryonic/larval trachea   (Auld et al., 1995) thoracico-abdominal ganglion | medial   (Auld et al., 1995) first instar larval stage   subperineurial glial cell   (Strigini et al., 2006)
Additional Descriptive Data
	Gli protein is expressed in most peripheral glia, in some exit glia, and in a number of midline glia. Staining of peripheral glia is first detected at stage 13 and becomes stronger through later stages. At stages 16-17, the entire surface of these glia appears to stain. The Gli-expressing glia extend from the nerve roots just inside the CNS along most of the major peripheral nerves, including the ISN up to the main tracheal trunk and along the two SN branches. Gli protein is expressed on all glia associated with the peripheral motor and sensory nerves but is not expressed on glia associated with sensory structures. Gli protein is also observed in a pair of midline glial cells at stages 16 and 17, in the epidermis from stage 12, and in the trachea and hindgut. In larvae, faint staining is observe in the midline of the thoracic ganglia, along the large nerve trunks leaving the CNS, in leg and antennal discs, in trachea and in the PNS. (Auld et al., 1995)
Marker for
	subperineurial glial cell
Subcellular Localization (GO Cellular Component)
CV term Evidence References
plasma membrane inferred from direct assay (Auld et al., 1995) septate junction inferred from direct assay (Schulte et al., 2003)
Expression Deduced from Reporters
Reporter: P{GawB}GlirL82.29 Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   peripheral glial cell   (Sepp and Auld, 2003)
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval trachea. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, larval/adult hindgut, larval/adult salivary gland, adult spermathecae, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    127.6 Larval Midgut    24.8 Larval Hindgut    297.8 Larval Malpighian Tubules    52.7 Larval Fat Body    26.1 Larval Salivary Gland    390.4 Larval Trachea    801.2 Larval Carcass    411.275 Adult Head    234.2 Adult Eye    378.5 Adult Brain    33 Adult Thoracic-Abdominal Ganglion    55.4 Adult Crop    311.6 Adult Midgut    37.2 Adult Hindgut    171.3 Adult Malpighian Tubules    31.1 Adult Fat Body    21.5 Adult Salivary Gland    188.7 Adult Heart    17.525 Adult VirginFemale Spermatheca    219.5 Adult InseminatedFemale Spermatheca    343.1 Adult Ovary    53.6 Adult Testis    49.7 Adult Male Accessory Gland    157.2 Adult Carcass    111.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    127.6 Larval Midgut    24.8 Larval Hindgut    297.8 Larval Malpighian Tubules    52.7 Larval Fat Body    26.1 Larval Salivary Gland    390.4 Larval Trachea  (801.2) Larval Carcass    411.275 Adult Head    234.2 Adult Eye    378.5 Adult Brain    33 Adult Thoracic-Abdominal Ganglion    55.4 Adult Crop    311.6 Adult Midgut    37.2 Adult Hindgut    171.3 Adult Malpighian Tubules    31.1 Adult Fat Body    21.5 Adult Salivary Gland    188.7 Adult Heart    17.525 Adult VirginFemale Spermatheca    219.5 Adult InseminatedFemale Spermatheca    343.1 Adult Ovary    53.6 Adult Testis    49.7 Adult Male Accessory Gland    157.2 Adult Carcass    111.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    127.6 Larval Midgut    24.8 Larval Hindgut    297.8 Larval Malpighian Tubules    52.7 Larval Fat Body    26.1 Larval Salivary Gland    390.4 Larval Trachea    801.2 Larval Carcass    411.275 Adult Head    234.2 Adult Eye    378.5 Adult Brain    33 Adult Thoracic-Abdominal Ganglion    55.4 Adult Crop    311.6 Adult Midgut    37.2 Adult Hindgut    171.3 Adult Malpighian Tubules    31.1 Adult Fat Body    21.5 Adult Salivary Gland    188.7 Adult Heart    17.525 Adult VirginFemale Spermatheca    219.5 Adult InseminatedFemale Spermatheca    343.1 Adult Ovary    53.6 Adult Testis    49.7 Adult Male Accessory Gland    157.2 Adult Carcass    111.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    127.6 Larval Midgut    24.8 Larval Hindgut    297.8 Larval Malpighian Tubules    52.7 Larval Fat Body    26.1 Larval Salivary Gland    390.4 Larval Trachea    801.2 Larval Carcass    411.275 Adult Head    234.2 Adult Eye    378.5 Adult Brain    33 Adult Thoracic-Abdominal Ganglion    55.4 Adult Crop    311.6 Adult Midgut    37.2 Adult Hindgut    171.3 Adult Malpighian Tubules    31.1 Adult Fat Body    21.5 Adult Salivary Gland    188.7 Adult Heart    17.525 Adult VirginFemale Spermatheca    219.5 Adult InseminatedFemale Spermatheca    343.1 Adult Ovary    53.6 Adult Testis    49.7 Adult Male Accessory Gland    157.2 Adult Carcass    111.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    127.6 Larval Midgut    24.8 Larval Hindgut    297.8 Larval Malpighian Tubules    52.7 Larval Fat Body    26.1 Larval Salivary Gland    390.4 Larval Trachea    801.2 Larval Carcass    411.275 Adult Head    234.2 Adult Eye    378.5 Adult Brain    33 Adult Thoracic-Abdominal Ganglion    55.4 Adult Crop    311.6 Adult Midgut    37.2 Adult Hindgut    171.3 Adult Malpighian Tubules    31.1 Adult Fat Body    21.5 Adult Salivary Gland    188.7 Adult Heart    17.525 Adult VirginFemale Spermatheca    219.5 Adult InseminatedFemale Spermatheca    343.1 Adult Ovary    53.6 Adult Testis    49.7 Adult Male Accessory Gland    157.2 Adult Carcass    111.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    127.6 Larval Midgut    24.8 Larval Hindgut    297.8 Larval Malpighian Tubules    52.7 Larval Fat Body    26.1 Larval Salivary Gland    390.4 Larval Trachea  801.2 Larval Carcass    411.275 Adult Head    234.2 Adult Eye    378.5 Adult Brain    33 Adult Thoracic-Abdominal Ganglion    55.4 Adult Crop    311.6 Adult Midgut    37.2 Adult Hindgut    171.3 Adult Malpighian Tubules    31.1 Adult Fat Body    21.5 Adult Salivary Gland    188.7 Adult Heart    17.525 Adult VirginFemale Spermatheca    219.5 Adult InseminatedFemale Spermatheca    343.1 Adult Ovary    53.6 Adult Testis    49.7 Adult Male Accessory Gland    157.2 Adult Carcass    111.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    127.6 Larval Midgut    24.8 Larval Hindgut    297.8 Larval Malpighian Tubules    52.7 Larval Fat Body    26.1 Larval Salivary Gland    390.4 Larval Trachea    801.2 Larval Carcass    411.275 Adult Head    234.2 Adult Eye    378.5 Adult Brain    33 Adult Thoracic-Abdominal Ganglion    55.4 Adult Crop    311.6 Adult Midgut    37.2 Adult Hindgut    171.3 Adult Malpighian Tubules    31.1 Adult Fat Body    21.5 Adult Salivary Gland    188.7 Adult Heart    17.525 Adult VirginFemale Spermatheca    219.5 Adult InseminatedFemale Spermatheca    343.1 Adult Ovary    53.6 Adult Testis    49.7 Adult Male Accessory Gland    157.2 Adult Carcass    111.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    127.6 Larval Midgut    24.8 Larval Hindgut    297.8 Larval Malpighian Tubules    52.7 Larval Fat Body    26.1 Larval Salivary Gland    390.4 Larval Trachea    801.2 Larval Carcass    411.275 Adult Head    234.2 Adult Eye    378.5 Adult Brain    33 Adult Thoracic-Abdominal Ganglion    55.4 Adult Crop    311.6 Adult Midgut    37.2 Adult Hindgut    171.3 Adult Malpighian Tubules    31.1 Adult Fat Body    21.5 Adult Salivary Gland    188.7 Adult Heart    17.525 Adult VirginFemale Spermatheca    219.5 Adult InseminatedFemale Spermatheca    343.1 Adult Ovary    53.6 Adult Testis    49.7 Adult Male Accessory Gland    157.2 Adult Carcass    111.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    234.2   NA  Eye    378.5   NA  Brain    33   127.6  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    55.4   NA  Crop    311.6   24.8  Midgut    37.2   297.8  Hindgut    171.3   52.7  Malpighian Tubules    no informative data   26.1  Fat Body    21.5   390.4  Salivary Gland    188.7   NA  Heart    17.525   801.2  Trachea    NA   NA  VirginFemale Spermatheca    219.5   NA  InseminatedFemale Spermatheca    343.1   NA  Ovary    53.6   NA  Testis    49.7   NA  Male Accessory Gland    157.2   411.275  Carcass    111.8 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    9 central nervous system, pupae P8    11 head, virgin 1-day female    7 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    6 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    10 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    24 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    17 digestive system, 4-day adult    11 digestive system, 20-day adult    17 fat body, larvae L3 wandering    3 fat body, white prepupae    5 fat body, pupae P8    8 carcass, larvae L3 wandering    27 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    3 ovary, mated 4-day female    2 testis, mated 4-day male    3 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (31) central nervous system, larvae L3    9 central nervous system, pupae P8    11 head, virgin 1-day female    7 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    6 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    10 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    24 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    17 digestive system, 4-day adult    11 digestive system, 20-day adult    17 fat body, larvae L3 wandering    3 fat body, white prepupae    5 fat body, pupae P8    8 carcass, larvae L3 wandering  (27) carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    3 ovary, mated 4-day female    2 testis, mated 4-day male    3 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    9 central nervous system, pupae P8    11 head, virgin 1-day female    7 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    6 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    10 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    24 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    17 digestive system, 4-day adult    11 digestive system, 20-day adult    17 fat body, larvae L3 wandering    3 fat body, white prepupae    5 fat body, pupae P8    8 carcass, larvae L3 wandering    27 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    3 ovary, mated 4-day female    2 testis, mated 4-day male    3 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    9 central nervous system, pupae P8    11 head, virgin 1-day female    7 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    6 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    10 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    24 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    17 digestive system, 4-day adult    11 digestive system, 20-day adult    17 fat body, larvae L3 wandering    3 fat body, white prepupae    5 fat body, pupae P8    8 carcass, larvae L3 wandering    27 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    3 ovary, mated 4-day female    2 testis, mated 4-day male    3 accessory gland, mated 4-day male    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    9 central nervous system, pupae P8    11 head, virgin 1-day female    7 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    6 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    10 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    24 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    17 digestive system, 4-day adult    11 digestive system, 20-day adult    17 fat body, larvae L3 wandering    3 fat body, white prepupae    5 fat body, pupae P8    8 carcass, larvae L3 wandering    27 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    3 ovary, mated 4-day female    2 testis, mated 4-day male    3 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  31 central nervous system, larvae L3    9 central nervous system, pupae P8    11 head, virgin 1-day female    7 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    6 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    10 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    24 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    17 digestive system, 4-day adult    11 digestive system, 20-day adult    17 fat body, larvae L3 wandering    3 fat body, white prepupae    5 fat body, pupae P8    8 carcass, larvae L3 wandering  27 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    3 ovary, mated 4-day female    2 testis, mated 4-day male    3 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    9 central nervous system, pupae P8    11 head, virgin 1-day female    7 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    6 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    10 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    24 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    17 digestive system, 4-day adult    11 digestive system, 20-day adult    17 fat body, larvae L3 wandering    3 fat body, white prepupae    5 fat body, pupae P8    8 carcass, larvae L3 wandering    27 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    3 ovary, mated 4-day female    2 testis, mated 4-day male    3 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    9 central nervous system, pupae P8    11 head, virgin 1-day female    7 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    6 head, mated 4-day female    4 head, mated 20-day female    5 head, mated 1-day male    7 head, mated 4-day male    7 head, mated 20-day male    10 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    24 digestive system, larvae L3 wandering    18 digestive system, 1-day adult    17 digestive system, 4-day adult    11 digestive system, 20-day adult    17 fat body, larvae L3 wandering    3 fat body, white prepupae    5 fat body, pupae P8    8 carcass, larvae L3 wandering    27 carcass, 1-day adult    4 carcass, 4-day adult    4 carcass, 20-day adult    5 ovary, virgin 4-day female    3 ovary, mated 4-day female    2 testis, mated 4-day male    3 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 06-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    21 embryo 04-06hr    41 embryo 06-08hr    56 embryo 08-10hr    58 embryo 10-12hr    69 embryo 12-14hr    48 embryo 14-16hr    50 embryo 16-18hr    50 embryo 18-20hr    38 embryo 20-22hr    21 embryo 22-24hr    23 larva L1    13 larva L2    13 larva L3 12hr old    10 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    30 white prepupae new    40 white prepupae 12hr    26 white prepupae 24hr    40 pupae 2d postWPP    24 pupae 3d postWPP    30 pupae 4d postWPP    10 adult male 01day    9 adult male 05day    9 adult male 30day    9 adult female 01day    8 adult female 05day    6 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    21 embryo 04-06hr  (41) embryo 06-08hr  (56) embryo 08-10hr  (58) embryo 10-12hr  (69) embryo 12-14hr  (48) embryo 14-16hr  (50) embryo 16-18hr  (50) embryo 18-20hr  (38) embryo 20-22hr    21 embryo 22-24hr    23 larva L1    13 larva L2    13 larva L3 12hr old    10 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9  (30) white prepupae new  (40) white prepupae 12hr  26 white prepupae 24hr  (40) pupae 2d postWPP    24 pupae 3d postWPP  (30) pupae 4d postWPP    10 adult male 01day    9 adult male 05day    9 adult male 30day    9 adult female 01day    8 adult female 05day    6 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    21 embryo 04-06hr    41 embryo 06-08hr    56 embryo 08-10hr    58 embryo 10-12hr    69 embryo 12-14hr    48 embryo 14-16hr    50 embryo 16-18hr    50 embryo 18-20hr    38 embryo 20-22hr    21 embryo 22-24hr    23 larva L1    13 larva L2    13 larva L3 12hr old    10 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    30 white prepupae new    40 white prepupae 12hr    26 white prepupae 24hr    40 pupae 2d postWPP    24 pupae 3d postWPP    30 pupae 4d postWPP    10 adult male 01day    9 adult male 05day    9 adult male 30day    9 adult female 01day    8 adult female 05day    6 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    21 embryo 04-06hr    41 embryo 06-08hr    56 embryo 08-10hr    58 embryo 10-12hr    69 embryo 12-14hr    48 embryo 14-16hr    50 embryo 16-18hr    50 embryo 18-20hr    38 embryo 20-22hr    21 embryo 22-24hr    23 larva L1    13 larva L2    13 larva L3 12hr old    10 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    30 white prepupae new    40 white prepupae 12hr    26 white prepupae 24hr    40 pupae 2d postWPP    24 pupae 3d postWPP    30 pupae 4d postWPP    10 adult male 01day    9 adult male 05day    9 adult male 30day    9 adult female 01day    8 adult female 05day    6 adult female 30day    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    21 embryo 04-06hr    41 embryo 06-08hr    56 embryo 08-10hr    58 embryo 10-12hr    69 embryo 12-14hr    48 embryo 14-16hr    50 embryo 16-18hr    50 embryo 18-20hr    38 embryo 20-22hr    21 embryo 22-24hr    23 larva L1    13 larva L2    13 larva L3 12hr old    10 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    30 white prepupae new    40 white prepupae 12hr    26 white prepupae 24hr    40 pupae 2d postWPP    24 pupae 3d postWPP    30 pupae 4d postWPP    10 adult male 01day    9 adult male 05day    9 adult male 30day    9 adult female 01day    8 adult female 05day    6 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    21 embryo 04-06hr  (41) embryo 06-08hr  (56) embryo 08-10hr  (58) embryo 10-12hr  (69) embryo 12-14hr  (48) embryo 14-16hr  (50) embryo 16-18hr  (50) embryo 18-20hr  (38) embryo 20-22hr    21 embryo 22-24hr    23 larva L1    13 larva L2    13 larva L3 12hr old    10 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9  30 white prepupae new  (40) white prepupae 12hr  26 white prepupae 24hr  (40) pupae 2d postWPP    24 pupae 3d postWPP  30 pupae 4d postWPP    10 adult male 01day    9 adult male 05day    9 adult male 30day    9 adult female 01day    8 adult female 05day    6 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    21 embryo 04-06hr    41 embryo 06-08hr    56 embryo 08-10hr    58 embryo 10-12hr    69 embryo 12-14hr    48 embryo 14-16hr    50 embryo 16-18hr    50 embryo 18-20hr    38 embryo 20-22hr    21 embryo 22-24hr    23 larva L1    13 larva L2    13 larva L3 12hr old    10 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    30 white prepupae new    40 white prepupae 12hr    26 white prepupae 24hr    40 pupae 2d postWPP    24 pupae 3d postWPP    30 pupae 4d postWPP    10 adult male 01day    9 adult male 05day    9 adult male 30day    9 adult female 01day    8 adult female 05day    6 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5 embryo 02-04hr    21 embryo 04-06hr    41 embryo 06-08hr    56 embryo 08-10hr    58 embryo 10-12hr    69 embryo 12-14hr    48 embryo 14-16hr    50 embryo 16-18hr    50 embryo 18-20hr    38 embryo 20-22hr    21 embryo 22-24hr    23 larva L1    13 larva L2    13 larva L3 12hr old    10 larva L3 puffstage 1-2    11 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    30 white prepupae new    40 white prepupae 12hr    26 white prepupae 24hr    40 pupae 2d postWPP    24 pupae 3d postWPP    30 pupae 4d postWPP    10 adult male 01day    9 adult male 05day    9 adult male 30day    9 adult female 01day    8 adult female 05day    6 adult female 30day    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    2 embryonic 1182-4H    4 embryonic GM2    12 embryonic Kc167    11 embryonic S1    19 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    8 wing disc ML-DmD8    5 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    16 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    10 ovary fGS/OSS    2 ovary OSC    6 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    2 embryonic 1182-4H    4 embryonic GM2    12 embryonic Kc167    11 embryonic S1    19 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    8 wing disc ML-DmD8    5 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    16 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    10 ovary fGS/OSS    2 ovary OSC    6 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    2 embryonic 1182-4H    4 embryonic GM2    12 embryonic Kc167    11 embryonic S1    19 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    8 wing disc ML-DmD8    5 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    16 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    10 ovary fGS/OSS    2 ovary OSC    6 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    2 embryonic 1182-4H    4 embryonic GM2    12 embryonic Kc167    11 embryonic S1    19 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    8 wing disc ML-DmD8    5 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    16 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    10 ovary fGS/OSS    2 ovary OSC    6 ovary OSS    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    2 embryonic 1182-4H    4 embryonic GM2    12 embryonic Kc167    11 embryonic S1    19 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    8 wing disc ML-DmD8    5 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    16 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    10 ovary fGS/OSS    2 ovary OSC    6 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    2 embryonic 1182-4H    4 embryonic GM2    12 embryonic Kc167    11 embryonic S1    19 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    8 wing disc ML-DmD8    5 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    16 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    10 ovary fGS/OSS    2 ovary OSC    6 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    2 embryonic 1182-4H    4 embryonic GM2    12 embryonic Kc167    11 embryonic S1    19 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    8 wing disc ML-DmD8    5 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    16 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    10 ovary fGS/OSS    2 ovary OSC    6 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    4 Schneider line 2 Sg4    2 embryonic 1182-4H    4 embryonic GM2    12 embryonic Kc167    11 embryonic S1    19 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    8 wing disc ML-DmD8    5 wing disc ML-DmD9    8 wing disc ML-DmD16-c3    6 wing disc ML-DmD21    16 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    5 eye-antennal disc ML-DmD11    8 antennal disc ML-DmD20-c5    6 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    15 tumorous blood cells mbn2    10 ovary fGS/OSS    2 ovary OSC    6 ovary OSS    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    6 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    6 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    6 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    6 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    6 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    6 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    6 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    6 heat shock, 4-day adult    6 Cadmium 50 mM 6 hrs, larvae L3    8 Cadmium 50 mM 12 hrs, larvae L3    8 Cadmium 50 mM 48 hrs, 4-day adult    8 Cadmium 100 mM 48 hrs, 4-day adult    10 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    7 Zinc 4.5 mM 48 hrs, 4-day adult    7 Ethanol 2.5% 3 hrs, larvae L3    7 Ethanol 5% 3 hrs, larvae L3    12 Ethanol 10% 3 hrs, larvae L3    9 Caffeine 1.5 mg/ml 4 hrs, larvae L3    9 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    4 Caffeine 25 mg/ml 48 hrs, 4-day adult    6 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    11 Rotenone 2 μg 12 hrs, larvae L3    8 Rotenone 8 μg 12 hrs, larvae L3    8 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_11 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • RE15719 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001987 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3903-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Gli Stages(s) 1-3 Stages(s) 4-6 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele cell lethal | somatic clone Glidv3 lethal Gli69G7 GliAE2Δ4b GliAE2Δ6a GliAE2Δ45 GliJ29Δ7b lethal (with Gli3) Glidv5 lethal (with Glidv1) Glidv5 lethal (with Glidv3) Glidv5 lethal (with Glidv5) Gli3 Glidv1 Glidv3 lethal | embryonic stage GliAE2Δ45 lethal | embryonic stage | recessive Gli3 Gli4 lethal | partially | recessive Glidv5 lethal | recessive Gli1 viable GliAE2 GliAE2Δ4a GliEY11600 GliJ29 Glik09033 GlirL82 viable, with Scer\GAL4pnr-MD237 GliGD1735 Sterility Allele fertile GliEY11600 Glik09033 Other Phenotypes Allele cell polarity defective Glidv5 cell polarity defective (with Glidv1) Glidv5 cell polarity defective (with Glidv3) Glidv5 cell polarity defective (with Glidv5) Glidv1 Glidv3 GliRAR77 cell polarity defective (with GliRAR77) Glidv5 increased cell death, with Scer\GAL4ap-md544 GliFF.Scer\UAS GliScer\UAS.cPa increased cell number, with Scer\GAL4ap-md544 GliDD.Scer\UAS GliFF.Scer\UAS GliScer\UAS.cPa meiotic cell cycle defective | dominant GliScim neuroanatomy defective | larval stage, with Scer\GAL4elav-C155 GliEP2306 visible GliAE2Δ45 visible, with Scer\GAL4pnr-MD237 GliGD1735 visible, with Scer\GAL4sca-537.4 GliEP2306 Phenotype manifest in Allele anterior fascicle & synapse, with Scer\GAL4elav-C155 GliEP2306 border follicle cell | somatic clone Gli69G7 dorsal trunk primordium GliJ29-41bl dorsocentral bristle, with Scer\GAL4sca-537.4 GliEP2306 embryonic/first instar larval cuticle Gliunspecified embryonic peripheral glial cell 4 GliAE2Δ45 GliAE2Δ4b GliAE2Δ6a GliJ29Δ7b embryonic peripheral glial cell 10 GliAE2Δ45 GliAE2Δ4b GliAE2Δ6a GliJ29Δ7b embryonic salivary gland & epithelial cell Gli1 epithelial cell GliAE2Δ45 intermediate peripheral glial cell of ISN GliAE2Δ45 GliAE2Δ4b GliAE2Δ6a GliJ29Δ7b intersegmental nerve, with Scer\GAL4elav-C155 GliEP2306 macrochaeta GliBG00965 peripheral glial cell 4 of SNc GliAE2Δ45 GliAE2Δ4b GliAE2Δ6a GliJ29Δ7b pleated septate junction GliAE2Δ45 scutellar bristle, with Scer\GAL4sca-537.4 GliEP2306 septate junction Gli1 GliAE2Δ45 tormogen cell, with Scer\GAL4sca-537.4 GliEP2306 trichogen cell, with Scer\GAL4pnr-MD237 GliGD1735 wing | distal (with Glidv3) Glidv5 wing | distal (with Glidv5) Glidv3 wing disc, with Scer\GAL4ap-md544 GliScer\UAS.cPa GliDD.Scer\UAS GliFF.Scer\UAS wing hair Glidv5 wing hair (with Glidv1) Glidv5 wing hair (with Glidv3) Glidv5 wing hair (with Glidv5) GliRAR77 Glidv1 Glidv3 wing hair (with GliRAR77) Glidv5
Classical Alleles ( 37 )
For All Classical Alleles Show
Allele of Gli Class Mutagen Stocks Known lesion Gli1 ethyl methanesulfonate 2 -- GliEY11600 P-element activity 1 -- GliRAR77 ethyl methanesulfonate 1 Yes GlirL82 P-element activity 1 Yes GliAE2Δ45 amorphic allele - genetic evidence Delta2-3 P-element activity 0 Yes GliAE2Δ4b amorphic allele - genetic evidence Delta2-3 P-element activity 0 Yes GliAE2Δ6a amorphic allele - genetic evidence Delta2-3 P-element activity 0 Yes GliJ29Δ7b amorphic allele - genetic evidence Delta2-3 P-element activity 0 Yes Gli2 ethyl methanesulfonate 0 -- Gli3 ethyl methanesulfonate 0 Yes Gli4 ethyl methanesulfonate 0 -- Gli69G7 chemical 0 -- GliAE2 P-element activity 0 Yes GliAE2Δ4a Delta2-3 P-element activity 0 Yes GliBG00965 P-element activity 0 Yes GliCPTI002756 piggyBac transposase 0 Yes GliCPTI002805 piggyBac transposase 0 Yes GliCQ1 ethyl methanesulfonate 0 -- Glidv1 ethyl methanesulfonate 0 Yes Glidv2 ethyl methanesulfonate 0 -- Glidv3 ethyl methanesulfonate 0 Yes Glidv4 ethyl methanesulfonate 0 -- Glidv5 ethyl methanesulfonate 0 Yes GliEP2306 P-element activity 0 Yes GliEP2322 P-element activity 0 Yes GliEP2416 P-element activity 0 Yes GliEP2463 P-element activity 0 Yes GliEP2615 P-element activity 0 Yes GliGS2150 0 Yes GliJ29-41bl 0 -- GliJ29 P-element activity 0 Yes Glik09033 P-element activity 0 Yes GlirL82.29 gene conversion 0 Yes GlirL82.4 gene conversion 0 Yes GlirL82.8 gene conversion 0 Yes GliScim Delta2-3 0 Yes Gliunspecified 0 --
Alleles Carried on Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Gli Class Mutagen Stocks Known lesion GliGD1735 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes GliHM05262 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes GliHMS01737 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes GliKK105971 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes GliDD.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes GliFF.Scer\UAS in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes GliMtnA.PA in vitro construct - regulatory fusion 0 Yes GliNIG.3903R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes GliScer\UAS.cPa in vitro construct - regulatory fusion 0 Yes GliScer\UAS.cSa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)b88c75 (Roote, 1995.3.27, Roote, 1996.8) Df(2L)BSC690 (Christensen et al., 2008.12.28) Df(2L)fn26 (Ashburner et al., 1990) Df(2L)k05007-mr2 (Roote, 2000.6.13) Df(2L)k05007-mr3 (Roote, 2000.6.13) Df(2L)k05007-mr6 (Roote, 2000.6.13) Df(2L)k05007-mr9 (Roote, 2000.6.13) Df(2L)k05007-mr13 (Roote, 2000.6.13) Df(2L)k05007-mr15 (Roote, 2000.6.13) Df(2L)k09033-mr9 (Roote, 2000.6.13) Df(2L)k09033-mr19 (Roote, 2000.6.13) Df(2L)n78l3 (Ashburner et al., 1990) Df(2L)osp29 (Cai et al., 2001, Auld et al., 1995) Df(2L)PZ05271-mr33 (Roote, 2000.6.13) Df(2L)r10 (Ashburner et al., 1990, Auld et al., 1995) Df(2L)Sco7 (Ashburner et al., 1990) Df(2L)Scorv16 (Ashburner et al., 1990) Df(2L)Scorv18 (Ashburner et al., 1990) Df(2L)SS1 (Ashburner et al., 1990) Df(2L)TE35D-2 (Ashburner et al., 1990) Df(2L)TE35D-3 (Ashburner et al., 1990) Df(2L)TE35D-6 (Ashburner et al., 1990) Df(2L)TE35D-13 (Ashburner et al., 1990) Df(2L)TE35D-14 (Ashburner et al., 1990) Df(2L)TE35D-16 (Ashburner et al., 1990) Df(2L)TE35D-19 (Ashburner et al., 1990) Df(2L)TE35D-21 (Ashburner et al., 1990) Df(2L)TE35D-22 (Cai et al., 2001, Ashburner et al., 1990) Df(2L)TE35D-23 (Ashburner et al., 1990) In(2L)dpps22Ldppd36R (Ashburner et al., 1990) In(2L)el18 (Ashburner et al., 1990) T(2;3)Scorv7 (Ashburner et al., 1990)
Not disrupted in	Df(2L)64j (Ashburner et al., 1990) Df(2L)A72 (Ashburner et al., 1990) Df(2L)A267 (Ashburner et al., 1990) Df(2L)ARR1 (Ashburner et al., 1990) Df(2L)b80e4 (Ashburner et al., 1990) Df(2L)el20 (Ashburner et al., 1990) Df(2L)el28 (Ashburner et al., 1990) Df(2L)fn12 (Ashburner et al., 1990) Df(2L)fn27 (Ashburner et al., 1990) Df(2L)H20 (Ashburner et al., 1990) Df(2L)noc11 (Ashburner et al., 1990) Df(2L)osp38 (Ashburner et al., 1990) Df(2L)PZ05271-mr15 (Roote, 2000.6.13) Df(2L)RA5 (Ashburner et al., 1990) Df(2L)rd9 (Ashburner et al., 1990) Df(2L)RM5 (Ashburner et al., 1990) Df(2L)RN2 (Ashburner et al., 1990) Df(2L)Scorv19 (Ashburner et al., 1990) Df(2L)Scorv25 (Ashburner et al., 1990) Df(2L)TE35BC-3 (Ashburner et al., 1990) Df(2L)TE35BC-4 (Ashburner et al., 1990) Df(2L)TE35BC-34 (Ashburner et al., 1990) Df(2L)TE35D-1 (Ashburner et al., 1990) Df(2L)TE35D-4 (Ashburner et al., 1990) Df(2L)TE35D-15 (Ashburner et al., 1990) Df(2L)TE35D-20 (Ashburner et al., 1990) In(2LR)noc4LScorv9R (Cai et al., 2001) In(2LR)Scorv1-DV7 (Ashburner et al., 1990)
Duplicated in	Dp(2;3)osp3 (Ashburner et al., 1990) In(2L)C163.41LC158R (Ashburner et al., 1990)
Not duplicated in	Dp(2;1)Scorv23 (Ashburner et al., 1990) Dp(2;2)GYL (Ashburner et al., 1990) Dp(2;2)TE35B-54L (Ashburner et al., 1990) In(2L)Scorv17LC158R (Ashburner et al., 1990)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1735} NA P{KK105971} NA P{NIG.3903R} NA P{TRiP.HM05262} NA P{TRiP.HMS01737} NA P{UAS-Gli.DD} NA P{UAS-Gli.FF} NA P{UAS-Gli.P} NA P{UAS-Gli.S} NA GAL4 construct P{Gli-GAL4.J29.2} No
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}GliEP2306 NA P{EP}GliEP2322 NA P{EP}GliEP2416 NA P{EP}GliEP2463 NA P{EP}GliEP2615 NA P{EPgy2}GliEY11600 NA P{GSV1}GliGS2150 NA insertion of enhancer trap P{lacW}GliAE2 No P{lacW}GliJ29 No P{lacW}Glik09033 No P{lacW}l(2)SH1811SH1811 No P{PZ}GlirL82 No insertion of enhancer trap binary system P{GawB}GlirL82.4 No P{GawB}GlirL82.8 No P{GawB}GlirL82.29 No P{GawB}GlirL82 No miscellaneous insertions P{GT1}GliBG00965 NA P{PTT-GB}CB02989 NA P{SUPor-P}GliScim NA PBac{754.P.FSVS-0}GliCPTI002756 NA PBac{754.P.FSVS-0}GliCPTI002805 NA
Gene Ontology: Function, Process & Cellular Component ( 16 unique terms )
Terms Based on Experimental Evidence ( 9 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
border follicle cell migration inferred from mutant phenotype (Wang et al., 2006) establishment of blood-nerve barrier inferred from mutant phenotype (Auld et al., 1995) female meiosis chromosome segregation inferred from mutant phenotype (Dobie et al., 2001) maintenance of imaginal disc-derived wing hair orientation inferred from mutant phenotype (Venema et al., 2004) regulation of tube size, open tracheal system inferred from mutant phenotype (Paul et al., 2003) septate junction assembly inferred from mutant phenotype (Schulte et al., 2003) synaptic target recognition inferred from mutant phenotype (Kurusu et al., 2008)
Cellular Component
CV term Evidence References
plasma membrane inferred from direct assay (Auld et al., 1995) septate junction inferred from direct assay (Schulte et al., 2003)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
carboxylesterase activity inferred from sequence or structural similarity (Auld et al., 1995, Ashburner et al., 1999) NOT carboxylesterase activity inferred from key residues with PANTHER:PTN000168538 (assigned by RefGenome) (Gaudet et al., 2010) neurexin family protein binding inferred from biological aspect of ancestor with PANTHER:PTN000168538 (assigned by RefGenome) (Gaudet et al., 2010) receptor activity inferred from biological aspect of ancestor with PANTHER:PTN000168538 (assigned by RefGenome) (Gaudet et al., 2010)
Biological Process
CV term Evidence References
synapse assembly inferred from biological aspect of ancestor with PANTHER:PTN000168538 (assigned by RefGenome) (Gaudet et al., 2010)
Cellular Component
CV term Evidence References
cell surface inferred from biological aspect of ancestor with PANTHER:PTN000168538 (assigned by RefGenome) (Gaudet et al., 2010) integral to plasma membrane inferred from biological aspect of ancestor with PANTHER:PTN000168538 (assigned by RefGenome) (Gaudet et al., 2010) plasma membrane non-traceable author statement (Auld, 1995.7.14) synapse inferred from biological aspect of ancestor with PANTHER:PTN000168538 (assigned by RefGenome) (Gaudet et al., 2010)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Gli allele Gene References GliEP2306 H (Abdelilah-Seyfried et al., 2000) N (Abdelilah-Seyfried et al., 2000) pnr (Pena-Rangel et al., 2002) unspecified Nsf2 (Laviolette et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60941 DroID - A comprehensive database of gene and protein interactions. • FBgn0001987 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34927
Orthologs
OrthoDB Orthologs (31) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG62V91K Dipteran inclusive ortholog search EOG6TTGRV Insect inclusive ortholog search EOG6G79TB Arthropod inclusive ortholog search EOG67SQVR Metazoa inclusive ortholog search EOG66QKKF
Orthologs in Drosophila Species (EOG62V91K)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Gli     Drosophila simulans   Dsim\GD21942 Y   Drosophila sechellia   Dsec\GM14210 Y   Drosophila erecta   Dere\GG24195 Y   Drosophila yakuba   Dyak\GE19390 Y   Drosophila ananassae   Dana\GF14975 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA17762 Y   Drosophila persimilis   Dper\GL15437 Y   Drosophila willistoni   Dwil\GK24272 Y   Drosophila virilis   Dvir\GJ18005 Y   Drosophila mojavensis   Dmoj\GI17245 Y   Drosophila grimshawi   Dgri\GH13495 Y
Orthologs in non-Drosophila Dipterans (EOG6TTGRV)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL009055   Anopheles gambiae Malaria mosquito  Agam\AGAP008190   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ802072
Orthologs in non-Dipteran Insects (EOG6G79TB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Gli   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG001429   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH13339   Atta cephalotes Leafcutter ant  Acep\ACEP26512   Camponotus floridanus Florida carpenter ant  Cflo\CFLO12583   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20099   Linepithema humile Argentine ant  Lhum\LH19859   Pogonomyrmex barbatus Red harvester ant  Pbar\PB19852   Solenopsis invicta Red fire ant  Sinv\SINV14250   Acyrthosiphon pisum Pea aphid  Apim\ACYPI001162   Bombyx mori Silkmoth  Bmor\BGIBMGA005805   Pediculus humanus Human body louse  Phum\PHUM617310   Tribolium castaneum Red flour beetle  Tcas\Gli
Orthologs in non-Insect Arthropods (EOG67SQVR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Lrrc4b   Ixodes scapularis Deer tick  Isca\ISCW020290
Orthologs in non-Arthropod Metazoa (EOG66QKKF)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\glit-1
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD21942 Drosophila sechellia Dsec\GM14210 Drosophila erecta Dere\GG24195 Drosophila yakuba Dyak\GE19390 Drosophila ananassae Dana\GF14975 Drosophila pseudoobscura pseudoobscura Dpse\GA17762 Drosophila persimilis Dper\GL15437 Drosophila willistoni Dwil\GK24272 Drosophila virilis Dvir\GJ18005 Drosophila mojavensis Dmoj\GI17245 Drosophila grimshawi Dgri\GH13495
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	9093 P{PZ}GlirL82; ry506 20686 y1 w67c23; P{EPgy2}GliEY11600 38284 y1 sc* v1; P{TRiP.HMS01737}attP40 3595 b1 Gli1 pr1 cn1 bw1/CyO 25142 b1 GliRAR77 pr1 cn1 bw1/CyO 31869 y1 sc* v1; P{TRiP.HM05262}attP2/TM3, Sb1
Kyoto	107118 b1 Gli1 pr1 cn1 bw1/CyO
VDRC	v107258 P{KK105971}VIE-260B v37115 w1118; P{GD1735}v37115 v37116 w1118; P{GD1735}v37116
Genomic Clones ( 2 )
	BACR06K01 BACR44L22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 98 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE15719 RE37203
Other clones	FI18641
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE01009 RE03931 RE05331 RE08245 RE21581 RE25637 RE27123 RE28510 RE29560 RE30287 RE32173 RE32271 RE35201 RE37261 RE42075 RE45420 RE48213 RE54781
Other clones	10897 13426 30335 31761 33131 33139 35767 40513 56538 58216 66659 72420 78329 108217 120729 153959 159796 177196 193048 273730 CK01.33D.C11 CK01.56A.H7 CK01.85C.G12 CK01.90A.C3 CK01.96C.C2 CK01.120D.C12 CK01.125B.E6 CK01.131B.B8 EK045222 EK046952 EK056308 EK067660 EK070810 EK074941 EK092542 EK096039 EK111238 EK114810 EK131708 EK139614 EK141719 EK143739 EK143755 EK153617 EK161016 EK166206 EK166451 EK169013 EK194725 EK200949 EK208059 EK234811 EK240557 EK257454 EK262938 EK275260 EK281912 EK295910 EK308607 EP03557 RP004086171 RP004105968 RP004109553 RP004186891 RP004195530 RP004203661 RP004205371 RP004215078 RP004220374 RP004240638 RP004254373 RP004313138 RP004366748 RP004366886 RP004376550 RP004507858 RP004510243
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0001987 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34927
Antibody Information
	monoclonal, polyclonal (Auld et al., 1995)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Gli CG3903 (Kodira, 1999.11)
Source for database merge of
Additional comments	FlyBase curator comment: "EP2416" overexpression phenotype stated to be due to its effect on Gli but orientation of the P{EP} element suggests otherwise. (Pena-Rangel et al., 2002)
Other Comments
	Appears to function to stabilize and align prehairs relative to anterior-posterior cell boundaries during pupal wing development. (Venema et al., 2004) Gli encodes a novel transmembrane protein. (Auld et al., 1995) Gli is required for the formation of the peripheral blood nerve barrier. (Auld et al., 1995) In mutant embryos peripheral glia develop normally in terms of migration and differentiation except that ultrastructurally and physiologically they do not form a complete blood-nerve barrier. As a result peripheral motor axons are exposed to high K+ haemolymph, action potentials fails to propagate and the embryos are nearly paralysed. (Auld et al., 1995) 11 additional alleles are discussed but are not named. (Ashburner et al., 1990)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057254 NM_165127 NM_165128 NM_165129 NM_165130 RefSeq (Proteins) • NP_476602 NP_723928 NP_723929 NP_723930 NP_723931 DDBJ / EMBL / GenBank • AAC41579 AAF44964 AAF53482 AAN10910 AAN10911 AAN10912 AAN10913 AAO47870 AAQ22486 AE003414 AQ025882 AQ073477 AQ073491 AQ073569 AQ073609 AQ073729 BI172989 BI240370 BT004892 BT010017 CL868502 L39083 Z50443 Entrez Gene - A searchable database of RefSeq genes. • 34927 UniProtKB/TrEMBL • Q7KT70 Q7YU32 Q8IP36 Q9NK80 Q86LF3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Carboxylesterase, type B (IPR002018) Carboxylesterase type B, conserved site (IPR019819) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE15719
Linkouts
	BioGRID - A database of protein and genetic interactions • 60941 DroID - A comprehensive database of gene and protein interactions. • FBgn0001987 DRSC - Results from RNAi screens. • FBgn0001987 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001987 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3903-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0001987 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34927 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /neural/gliotac.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34927 modMine - Data generated by the modENCODE project. • FBgn0001987
Synonyms & Secondary IDs ( 9 )
Reported As
Symbol Synonym	BG:DS09217.3 (Ashburner et al., 1999.10.12, Ashburner et al., 1999) CG3903 (Norga et al., 2003, Kraut et al., 2001, Kraut et al., 2001, Whitfield, 2000.11.28, Moorman et al., 2006, Laviolette et al., 2005, Keleman et al., 2009.8.5, Haussmann et al., 2008, Perkins et al., 2009, Ni et al., 2010.12.1) Gli (Jordan et al., 2005, Furuse and Tsukita, 2006, Laviolette et al., 2005, Stark et al., 2005, Blanco et al., 2010, Strigini et al., 2006, Buszczak et al., 2007, Xie and Auld, 2011, Christensen et al., 2008.12.28, Yi et al., 2008, Gilchrist et al., 2008, Schulte et al., 2006, Nahvi et al., 2009, Haussmann et al., 2008, Nilton et al., 2010, Padash-Barmchi et al., 2010, Dworkin et al., 2011, Jumbo-Lucioni et al., 2010, Kertesz et al., 2007, Japanese National Institute of Genetics, 2012.5.21, Tan et al., 2012) gli (Wu and Beitel, 2004, Salinas et al., 2001, Nilton et al., 2010, Eddison et al., 2012) l(2)35Dg (Ashburner et al., 1999, The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Roote, 1997.6.6, Alexandrova et al., 1996, Spradling et al., 1995, Auld et al., 1995, ) l(2)br45 (The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Ashburner et al., 1990, ) n(2)k09033 (Spradling, 1999.12.9)
Name Synonym	gliotactin (Jordan et al., 2005, Auld, 1995.7.14, Venema and Auld, 1999, Wu and Beitel, 2004, Norga et al., 2003, Sepp et al., 2000, Schmidt et al., 2011, Liévens et al., 2008, Edenfeld et al., 2006, Tiklova et al., 2010, Padash-Barmchi et al., 2010) Gliotactin (Daneman and Barres, 2005, Wang et al., 2006, Schotman et al., 2008, Yi et al., 2008, Schulte et al., 2006, Haussmann et al., 2008, Nilton et al., 2010, Kurusu et al., 2008, Kim et al., 2010, Tan et al., 2012)
Secondary FlyBase IDs
References ( 116 )
Generate a list of	All references relating to this gene ( 116 )
List References by type	Research paper  ( 59 ) Supplementary material  ( 11 ) Review  ( 8 ) Personal communication to FlyBase  ( 20 ) Abstract  ( 9 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Stock list  ( 2 ) Curated genome annotation  ( 1 ) Website  ( 2 ) Book  ( 1 )
Recent research papers ( 10 )
	Lindsley et al., 2013, PLoS ONE 8(2): e55915 Anent the Genomics of Spermatogenesis in Drosophila melanogaster. [FBrf0220812] Eddison et al., 2012, PLoS ONE 7(12): e51684 A genetic screen for olfactory habituation mutations in Drosophila: analysis of novel foraging alleles and an underlying neural circuit. [FBrf0220425] Förster and Luschnig, 2012, Nat. Cell Biol. 14(5): 526--534 Src42A-dependent polarized cell shape changes mediate epithelial tube elongation in Drosophila. [FBrf0218206] Schmidt et al., 2012, J. Neurosci. 32(22): 7466--7476 Kinesin heavy chain function in Drosophila glial cells controls neuronal activity. [FBrf0218491] Tan et al., 2012, PLoS Genet. 8(5): e1002681 MicroRNA-277 Modulates the Neurodegeneration Caused by Fragile X Premutation rCGG Repeats. [FBrf0218227] Baycin-Hizal et al., 2011, J. Proteome Res. 10(6): 2777--2784 GlycoFly: A Database of Drosophila N-linked Glycoproteins Identified Using SPEG-MS Techniques. [FBrf0213834] Dworkin et al., 2011, Genetics 187(4): 1171--1184 The effects of weak genetic perturbations on the transcriptome of the wing imaginal disc and its association with wing shape in Drosophila melanogaster. [FBrf0214376] Oshima and Fehon, 2011, J. Cell Sci. 124(16): 2861--2871 Analysis of protein dynamics within the septate junction reveals a highly stable core protein complex that does not include the basolateral polarity protein Discs large. [FBrf0214577] Schmidt et al., 2011, Glia 59(9): 1264--1272 Transcriptional regulation of peripheral glial cell differentiation in the embryonic nervous system of drosophila. [FBrf0214270] Xie and Auld, 2011, Development 138(17): 3813--3822 Integrins are necessary for the development and maintenance of the glial layers in the Drosophila peripheral nerve. [FBrf0214589] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...