l(2)35Dg, l(2)br45, BG:DS09217.3
Please see the GBrowse view of Dmel\Gli or the JBrowse view of Dmel\Gli for information on other features
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Gene model reviewed during 5.52
6.0 (northern blot)
956 (aa); 109 (kD predicted)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Gli using the Feature Mapper tool.
Comment: maternally deposited
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Gli transcripts are expressed in most peripheral glia, in some exit glia, and in a number of midline glia. Prior to glial staining, there is some epidermal staining in broad, diffuse stripes at early stage 12.
Gli is localized at tricellular tight junctions in columnar epithelial cells of the wing disc, as well as being found in intracellular vesicles.
Gli protein expression is enriched in centripetal cells relative to other cells in the egg chamber throughout migration.
Gli protein is expressed in most peripheral glia, in some exit glia, and in a number of midline glia. Staining of peripheral glia is first detected at stage 13 and becomes stronger through later stages. At stages 16-17, the entire surface of these glia appears to stain. The Gli-expressing glia extend from the nerve roots just inside the CNS along most of the major peripheral nerves, including the ISN up to the main tracheal trunk and along the two SN branches. Gli protein is expressed on all glia associated with the peripheral motor and sensory nerves but is not expressed on glia associated with sensory structures. Gli protein is also observed in a pair of midline glial cells at stages 16 and 17, in the epidermis from stage 12, and in the trachea and hindgut. In larvae, faint staining is observe in the midline of the thoracic ganglia, along the large nerve trunks leaving the CNS, in leg and antennal discs, in trachea and in the PNS.
GBrowse - Visual display of RNA-Seq signals
View Dmel\Gli in GBrowse 2
2-51
2-51
2-48.9
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
monoclonal, polyclonal
Appears to function to stabilize and align prehairs relative to anterior-posterior cell boundaries during pupal wing development.
Gli encodes a novel transmembrane protein.
Gli is required for the formation of the peripheral blood nerve barrier.
In mutant embryos peripheral glia develop normally in terms of migration and differentiation except that ultrastructurally and physiologically they do not form a complete blood-nerve barrier. As a result peripheral motor axons are exposed to high K+ haemolymph, action potentials fails to propagate and the embryos are nearly paralysed.
11 additional alleles are discussed but are not named.
