• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\wek

General Information
Symbol	Dmel\wek	Species	D. melanogaster
Name	weckle	Annotation symbol	CG4148
Feature type	protein_coding_gene	FlyBase ID	FBgn0001990
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	l(2)35Ea, BG:DS09217.5
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	35D4-35D4	Sequence location	2L:15,766,475..15,768,317 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene weckle is referred to in FlyBase by the symbol Dmel\wek (CG4148, FBgn0001990). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; protein homodimerization activity. There is experimental evidence that it is involved in the biological process: Toll signaling pathway; maternal specification of dorsal/ventral axis, oocyte, germ-line encoded; dorsal/ventral axis specification. 21 alleles are reported. The phenotypes of these alleles are annotated with: leg; wing. It has one annotated transcript and one annotated polypeptide. Protein features are: Zinc finger, AD-type; Zinc finger, C2H2; Zinc finger, C2H2-like; Zinc finger, C2H2-type/integrase, DNA-binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1623370_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of wek. Gene sequence location is 2L:15766475..15768317.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	Sequence features BKN23756 HFA03561
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 35D4-35D4   Limits computationally determined from genome sequence between P{lacW}CycEk05007&P{lacW}CycEk02602 and P{EP}crpEP721&P{lacW}crpk07829
Experimentally Determined Cytological Location
Cytogenetic map Notes References 35D-35D     (Luschnig et al., 2004) 35D1-35D2   (determined by in situ hybridisation)   (Ashburner et al., 1999) 35D1-35D2   (determined by in situ hybridisation)   (Spradling et al., 1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes	l(2)35Di, l(2)35Df and Gli are definitely distal of wek. (Roote, 2000.6.13)
Gene Model & Products
Please see the GBrowse view of Dmel\wek for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) wek-RA FBtr0080764  NM_080191   1659   470
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein wek-PA   FBpp0080323   53.2   470   7.05     NP_524930   AAF53484
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2-like (IPR015880) Zinc finger, C2H2 (IPR007087) Zinc finger, AD-type (IPR012934) Zinc finger, C2H2-type/integrase, DNA-binding (IPR013087)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202739   AA817333   AE014134 AAF53484   AE003414 AAF44966   AI455284   AI519311   AY051673 AAK93097   BI165551   BI166560   BI169589   BI483805   BP556962   BP556963   CK657762   CO176787   CO176863   CO185689   CO185863   CO188115   CO188586   CO193068   CO262563   CO262933   CO287995   CO288015   CO288927   CO289590   CO300781   CO308752   CO310213   CO330943   CO343779   CO345200   EC059196   EC081655   EC087502   EC194684   EC195256   EC196162   EC217383   EC229013   EC238225   EC256222   GH748295   GH753760   GH757130   GH757219   GH757951   GH770515   GH770977   GH778679   GH780528   GH781128   GH781468   GH781475   GH782969   GH786290   GH787566   GH792298   GH792988   GH795859   GH798030   GH798786   GH810384   GH814468   GH815920   GH817884   GH818734   GH823912   GH826043   GH827993   GH828389   GH829603   GH831269   GH832146   GH835989   GH839188   GH839900   GH841847   GH842474   GH842506   GH843627   GH846581   GH848801   GH848955   GH848966   GH849481   GH850440   GH853199   GH856562   GH859153   GH861025   GH862644   GH865935   GH866841   GH870424   GH872957   GH875001   GH876539   GH881342   GH885560   GH887580   GH892345   GH892603   GH894291   GH898354   GH900622   GH901747   GH905822   GH909874   GH912197   GH914740   GH916688   GH916931   GH917422   GH918160   GH921153   GH921461   GH922318   GH922776   GH922856   GH923549   GH925008   GH926355   GH931593   GH936322   GH937193   GH939787   GH940224
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VJN5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0001990    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0001990 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0001990 expression level Developmental Stage   Expression Level embryo 00-02hr    2612 embryo 02-04hr    3073 embryo 04-06hr    2296 embryo 06-08hr    1850 embryo 08-10hr    1751 embryo 10-12hr    1154 embryo 12-14hr    1089 embryo 14-16hr    1037 embryo 16-18hr    896 embryo 18-20hr    546 embryo 20-22hr    968 embryo 22-24hr    981 larva L1    458 larva L2    375 larva L3 12hr old    322 larva L3 puffstage 1-2    407 larva L3 puffstage 3-6    509 larva L3 puffstage 7-9    636 white prepupae new    572 white prepupae 12hr    539 white prepupae 24hr    692 pupae 2d postWPP    497 pupae 3d postWPP    324 pupae 4d postWPP    321 adult male 01day    326 adult male 05day    381 adult male 30day    391 adult female 01day    773 adult female 05day    1372 adult female 30day    1412 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2612) embryo 02-04hr  (3073) embryo 04-06hr  (2296) embryo 06-08hr  (1850) embryo 08-10hr  (1751) embryo 10-12hr  (1154) embryo 12-14hr  (1089) embryo 14-16hr  (1037) embryo 16-18hr  (896) embryo 18-20hr  (546) embryo 20-22hr  (968) embryo 22-24hr  (981) larva L1  (458) larva L2  (375) larva L3 12hr old  (322) larva L3 puffstage 1-2  (407) larva L3 puffstage 3-6  (509) larva L3 puffstage 7-9  (636) white prepupae new  (572) white prepupae 12hr  (539) white prepupae 24hr  (692) pupae 2d postWPP  (497) pupae 3d postWPP  (324) pupae 4d postWPP  (321) adult male 01day  (326) adult male 05day  (381) adult male 30day  (391) adult female 01day  (773) adult female 05day  (1372) adult female 30day  (1412) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2612) embryo 02-04hr  (3073) embryo 04-06hr  (2296) embryo 06-08hr  (1850) embryo 08-10hr  (1751) embryo 10-12hr    1154 embryo 12-14hr    1089 embryo 14-16hr    1037 embryo 16-18hr    896 embryo 18-20hr    546 embryo 20-22hr    968 embryo 22-24hr    981 larva L1    458 larva L2    375 larva L3 12hr old    322 larva L3 puffstage 1-2    407 larva L3 puffstage 3-6    509 larva L3 puffstage 7-9    636 white prepupae new    572 white prepupae 12hr    539 white prepupae 24hr    692 pupae 2d postWPP    497 pupae 3d postWPP    324 pupae 4d postWPP    321 adult male 01day    326 adult male 05day    381 adult male 30day    391 adult female 01day    773 adult female 05day    1372 adult female 30day  1412 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2612 embryo 02-04hr    3073 embryo 04-06hr    2296 embryo 06-08hr    1850 embryo 08-10hr    1751 embryo 10-12hr    1154 embryo 12-14hr    1089 embryo 14-16hr    1037 embryo 16-18hr    896 embryo 18-20hr    546 embryo 20-22hr    968 embryo 22-24hr    981 larva L1    458 larva L2    375 larva L3 12hr old    322 larva L3 puffstage 1-2    407 larva L3 puffstage 3-6    509 larva L3 puffstage 7-9    636 white prepupae new    572 white prepupae 12hr    539 white prepupae 24hr    692 pupae 2d postWPP    497 pupae 3d postWPP    324 pupae 4d postWPP    321 adult male 01day    326 adult male 05day    381 adult male 30day    391 adult female 01day    773 adult female 05day    1372 adult female 30day    1412 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2612 embryo 02-04hr    3073 embryo 04-06hr    2296 embryo 06-08hr    1850 embryo 08-10hr    1751 embryo 10-12hr    1154 embryo 12-14hr    1089 embryo 14-16hr    1037 embryo 16-18hr    896 embryo 18-20hr    546 embryo 20-22hr    968 embryo 22-24hr    981 larva L1    458 larva L2    375 larva L3 12hr old    322 larva L3 puffstage 1-2    407 larva L3 puffstage 3-6    509 larva L3 puffstage 7-9    636 white prepupae new    572 white prepupae 12hr    539 white prepupae 24hr    692 pupae 2d postWPP    497 pupae 3d postWPP    324 pupae 4d postWPP    321 adult male 01day    326 adult male 05day    381 adult male 30day    391 adult female 01day    773 adult female 05day    1372 adult female 30day    1412 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0001990 expression level Developmental Stage   Expression Level embryo 00-02hr    2612 embryo 02-04hr    3073 embryo 04-06hr    2296 embryo 06-08hr    1850 embryo 08-10hr    1751 embryo 10-12hr    1154 embryo 12-14hr    1089 embryo 14-16hr    1037 embryo 16-18hr    896 embryo 18-20hr    546 embryo 20-22hr    968 embryo 22-24hr    981 larva L1    458 larva L2    375 larva L3 12hr old    322 larva L3 puffstage 1-2    407 larva L3 puffstage 3-6    509 larva L3 puffstage 7-9    636 white prepupae new    572 white prepupae 12hr    539 white prepupae 24hr    692 pupae 2d postWPP    497 pupae 3d postWPP    324 pupae 4d postWPP    321 adult male 01day    326 adult male 05day    381 adult male 30day    391 adult female 01day    773 adult female 05day    1372 adult female 30day    1412 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2612) embryo 02-04hr  (3073) embryo 04-06hr  (2296) embryo 06-08hr  (1850) embryo 08-10hr  (1751) embryo 10-12hr  (1154) embryo 12-14hr  (1089) embryo 14-16hr  (1037) embryo 16-18hr  (896) embryo 18-20hr  (546) embryo 20-22hr  (968) embryo 22-24hr  (981) larva L1  (458) larva L2  (375) larva L3 12hr old  (322) larva L3 puffstage 1-2  (407) larva L3 puffstage 3-6  (509) larva L3 puffstage 7-9  (636) white prepupae new  (572) white prepupae 12hr  (539) white prepupae 24hr  (692) pupae 2d postWPP  (497) pupae 3d postWPP  (324) pupae 4d postWPP  (321) adult male 01day  (326) adult male 05day  (381) adult male 30day  (391) adult female 01day  (773) adult female 05day  (1372) adult female 30day  (1412) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2612) embryo 02-04hr  (3073) embryo 04-06hr  2296 embryo 06-08hr  1850 embryo 08-10hr  1751 embryo 10-12hr    1154 embryo 12-14hr    1089 embryo 14-16hr    1037 embryo 16-18hr    896 embryo 18-20hr    546 embryo 20-22hr    968 embryo 22-24hr    981 larva L1    458 larva L2    375 larva L3 12hr old    322 larva L3 puffstage 1-2    407 larva L3 puffstage 3-6    509 larva L3 puffstage 7-9    636 white prepupae new    572 white prepupae 12hr    539 white prepupae 24hr    692 pupae 2d postWPP    497 pupae 3d postWPP    324 pupae 4d postWPP    321 adult male 01day    326 adult male 05day    381 adult male 30day    391 adult female 01day    773 adult female 05day    1372 adult female 30day  1412 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2612 embryo 02-04hr    3073 embryo 04-06hr    2296 embryo 06-08hr    1850 embryo 08-10hr    1751 embryo 10-12hr    1154 embryo 12-14hr    1089 embryo 14-16hr    1037 embryo 16-18hr    896 embryo 18-20hr    546 embryo 20-22hr    968 embryo 22-24hr    981 larva L1    458 larva L2    375 larva L3 12hr old    322 larva L3 puffstage 1-2    407 larva L3 puffstage 3-6    509 larva L3 puffstage 7-9    636 white prepupae new    572 white prepupae 12hr    539 white prepupae 24hr    692 pupae 2d postWPP    497 pupae 3d postWPP    324 pupae 4d postWPP    321 adult male 01day    326 adult male 05day    381 adult male 30day    391 adult female 01day    773 adult female 05day    1372 adult female 30day    1412 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2612 embryo 02-04hr    3073 embryo 04-06hr    2296 embryo 06-08hr    1850 embryo 08-10hr    1751 embryo 10-12hr    1154 embryo 12-14hr    1089 embryo 14-16hr    1037 embryo 16-18hr    896 embryo 18-20hr    546 embryo 20-22hr    968 embryo 22-24hr    981 larva L1    458 larva L2    375 larva L3 12hr old    322 larva L3 puffstage 1-2    407 larva L3 puffstage 3-6    509 larva L3 puffstage 7-9    636 white prepupae new    572 white prepupae 12hr    539 white prepupae 24hr    692 pupae 2d postWPP    497 pupae 3d postWPP    324 pupae 4d postWPP    321 adult male 01day    326 adult male 05day    381 adult male 30day    391 adult female 01day    773 adult female 05day    1372 adult female 30day    1412 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0001990    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0001990 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0001990 expression level Tissue   Expression Level Larval Central Nervous System    58.85 Larval Midgut no informative data Larval Hindgut    33.1 Larval Malpighian Tubules    48 Larval Fat Body    72.7 Larval Salivary Gland    54.1 Larval Trachea    58 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain    34.3 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    33 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    24.975 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    24.1 Adult Ovary    147 Adult Testis    30.2 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    58.85 Larval Midgut no informative data Larval Hindgut    33.1 Larval Malpighian Tubules    48 Larval Fat Body    72.7 Larval Salivary Gland    54.1 Larval Trachea    58 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain    34.3 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    33 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    24.975 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    24.1 Adult Ovary    147 Adult Testis    30.2 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    58.85 Larval Midgut no informative data Larval Hindgut    33.1 Larval Malpighian Tubules    48 Larval Fat Body    72.7 Larval Salivary Gland    54.1 Larval Trachea    58 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain    34.3 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    33 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    24.975 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    24.1 Adult Ovary    147 Adult Testis    30.2 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    58.85 Larval Midgut no informative data Larval Hindgut    33.1 Larval Malpighian Tubules    48 Larval Fat Body    72.7 Larval Salivary Gland    54.1 Larval Trachea    58 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain    34.3 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    33 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    24.975 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    24.1 Adult Ovary    147 Adult Testis    30.2 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0001990 expression level Tissue   Expression Level Larval Central Nervous System    58.85 Larval Midgut no informative data Larval Hindgut    33.1 Larval Malpighian Tubules    48 Larval Fat Body    72.7 Larval Salivary Gland    54.1 Larval Trachea    58 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain    34.3 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    33 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    24.975 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    24.1 Adult Ovary    147 Adult Testis    30.2 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    58.85 Larval Midgut no informative data Larval Hindgut    33.1 Larval Malpighian Tubules    48 Larval Fat Body    72.7 Larval Salivary Gland    54.1 Larval Trachea    58 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain    34.3 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    33 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    24.975 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    24.1 Adult Ovary    147 Adult Testis    30.2 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    58.85 Larval Midgut no informative data Larval Hindgut    33.1 Larval Malpighian Tubules    48 Larval Fat Body    72.7 Larval Salivary Gland    54.1 Larval Trachea    58 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain    34.3 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    33 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    24.975 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    24.1 Adult Ovary    147 Adult Testis    30.2 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    58.85 Larval Midgut no informative data Larval Hindgut    33.1 Larval Malpighian Tubules    48 Larval Fat Body    72.7 Larval Salivary Gland    54.1 Larval Trachea    58 Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain    34.3 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    33 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    24.975 Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca    24.1 Adult Ovary    147 Adult Testis    30.2 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain     Adult Thoracic-Abdominal Ganglion no informative data Adult Crop     Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    no informative data   NA  Brain    34.3   58.85  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    33   no informative data  Midgut    no informative data   33.1  Hindgut    no informative data   48  Malpighian Tubules    no informative data   72.7  Fat Body    no informative data   54.1  Salivary Gland    no informative data   NA  Heart    24.975   58  Trachea    NA   NA  VirginFemale Spermatheca    no informative data   NA  InseminatedFemale Spermatheca    24.1   NA  Ovary    147   NA  Testis    30.2   NA  Male Accessory Gland    no informative data   no informative data  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001990 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4148-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | germline clone | non-rescuable maternal effect weklor lethal | embryonic stage | germline clone | non-rescuable maternal effect | recessive wek2L-34-30 wek2L-241-31 wek2L-355-34 lethal | pharate adult stage wekAM11 lethal | pupal stage wekEX14 weklor lethal | pupal stage (with wekEX14) weklor lethal | pupal stage (with weklor) wekEX14 lethal | recessive wekRAR14 viable wek05271a viable, with Scer\GAL4pnr-MD237 wekGD4369 Sterility Allele fertile wek05271a Other Phenotypes Allele visible | recessive wek05271a Phenotype manifest in Allele embryonic/first instar larval cuticle | germline clone | non-rescuable maternal effect | ventral wekRAR14 weklor wekEX14 embryonic/first instar larval cuticle | germline clone | non-rescuable maternal effect | ventral (with wekEX14) weklor embryonic/first instar larval cuticle | germline clone | non-rescuable maternal effect | ventral (with weklor) wekEX14 embryonic ventral epidermis | germline clone | non-rescuable maternal effect wekRAR14 weklor wekEX14 embryonic ventral epidermis | germline clone | non-rescuable maternal effect (with wekEX14) weklor embryonic ventral epidermis | germline clone | non-rescuable maternal effect (with weklor) wekEX14 filzkorper | germline clone | non-rescuable maternal effect wekRAR14 weklor wekEX14 leg wek05271a leg (with wekEX14) weklor leg (with weklor) wekEX14 wing wek05271a
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of wek Class Mutagen Stocks Known lesion wekAM11 ethyl methanesulfonate 1 -- wekRAR14 loss of function allele ethyl methanesulfonate 1 Yes wek05271a P-element activity 0 Yes wek2L-241-31 ethyl methanesulfonate 0 -- wek2L-34-30 ethyl methanesulfonate 0 -- wek2L-355-34 ethyl methanesulfonate 0 -- wekEX14 loss of function allele Delta2-3 0 Yes weklor ethyl methanesulfonate 0 Yes
Alleles Carried on Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Allele of wek Class Mutagen Stocks Known lesion wekGD4369 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes wekGLV21045 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes wekAct5C.PC in vitro construct - regulatory fusion 0 Yes wekC.Act5C in vitro construct - regulatory fusion 0 Yes wekC.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion 0 Yes wekdsRNA.3'.cCa in vitro construct - RNAi 0 Yes wekdsRNA.5'.cCa in vitro construct - RNAi 0 Yes wekM.Act5C in vitro construct - regulatory fusion 0 Yes wekN.Act5C.T:SV5\V5 in vitro construct - regulatory fusion 0 Yes wekN.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion 0 Yes wekNM.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion 0 Yes wekScer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion 0 Yes wekαTub84B.PC in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)A246 (Fossett et al., 1994) Df(2L)A337 (Fossett et al., 1994) Df(2L)Adh-nBR101 (Fossett et al., 1994) Df(2L)Adh-nBR120 (Fossett et al., 1994, Roote, 1996.1.11, Roote, 1996.8) Df(2L)Adh-nBR126 (Fossett et al., 1994) Df(2L)b88c75 (Alexandrova et al., 1996) Df(2L)b89e88a (Roote, 2000.6.5) Df(2L)el28 (Roote et al., 1996) Df(2L)Exel6037 (Ryder, 2004.4.26) Df(2L)fn26 (Ashburner et al., 1990) Df(2L)k05007-mr15 (Roote, 2000.6.13) Df(2L)n78l3 (Ashburner et al., 1990, Roote et al., 1996) Df(2L)osp29 (Cai et al., 2001) Df(2L)PZ05271-mr15 (Roote, 2000.6.13) Df(2L)PZ05271-mr45 (Roote, 2000.6.13) Df(2L)PZ05271-rv54 (Roote, 2000.6.13) Df(2L)r10 (Ashburner et al., 1990) Df(2L)Sco7 (Ashburner et al., 1990) Df(2L)Scorv10 (Roote et al., 1996) Df(2L)Scorv14 (Roote et al., 1996) Df(2L)Scorv16 (Ashburner et al., 1990) Df(2L)Scorv18 (Ashburner et al., 1990) Df(2L)SS1 (Ashburner et al., 1990) Df(2L)TE35BC-8 (Roote et al., 1996) Df(2L)TE35D-2 (Ashburner et al., 1990) Df(2L)TE35D-3 (Ashburner et al., 1990) Df(2L)TE35D-5 (Roote et al., 1996) Df(2L)TE35D-6 (Ashburner et al., 1990) Df(2L)TE35D-12 (Roote et al., 1996) Df(2L)TE35D-13 (Ashburner et al., 1990) Df(2L)TE35D-14 (Ashburner et al., 1990) Df(2L)TE35D-16 (Ashburner et al., 1990) Df(2L)TE35D-19 (Ashburner et al., 1990) Df(2L)TE35D-21 (Ashburner et al., 1990) Df(2L)TE35D-22 (Cai et al., 2001, Ashburner et al., 1990) Df(2L)TE35D-23 (Ashburner et al., 1990) Df(2L)TE35D-24 (Roote et al., 1996) In(2L)dpps22Ldppd36R (Ashburner et al., 1990) In(2L)el18 (Ashburner et al., 1990) In(2L)TE35B-13 (Roote et al., 1996, Roote, 1996.8) In(2LR)noc4LD6R (Roote et al., 1996) T(2;3)Scorv7 (Ashburner et al., 1990, Roote et al., 1996) Tp(2;2)A446 (Fossett et al., 1994)
Not disrupted in	Df(2L)64j (Ashburner et al., 1990) Df(2L)A47 (Fossett et al., 1994) Df(2L)A48 (BDGP Project Members, 1994-1999, Fossett et al., 1994) Df(2L)A63 (Fossett et al., 1994) Df(2L)A72 (Ashburner et al., 1990, Fossett et al., 1994) Df(2L)A178 (Fossett et al., 1994) Df(2L)A215 (Fossett et al., 1994) Df(2L)A217 (Fossett et al., 1994) Df(2L)A220 (Fossett et al., 1994) Df(2L)A245 (Fossett et al., 1994) Df(2L)A264 (Fossett et al., 1994) Df(2L)A266 (Fossett et al., 1994) Df(2L)A267 (Ashburner et al., 1990, Fossett et al., 1994) Df(2L)A376 (Fossett et al., 1994) Df(2L)A379 (Fossett et al., 1994) Df(2L)A400 (Fossett et al., 1994) Df(2L)A445 (Fossett et al., 1994) Df(2L)Adh-nBR100 (Fossett et al., 1994) Df(2L)Adh-nBR102 (Fossett et al., 1994) Df(2L)Adh-nBR103 (Fossett et al., 1994) Df(2L)Adh-nBR105 (Fossett et al., 1994) Df(2L)Adh-nBR117 (Fossett et al., 1994) Df(2L)Adh-nBR118 (Fossett et al., 1994) Df(2L)Adh-nBR119 (Fossett et al., 1994) Df(2L)Adh-nBR121 (Fossett et al., 1994) Df(2L)Adh-nBR122 (Fossett et al., 1994) Df(2L)Adh-nBR125 (Fossett et al., 1994) Df(2L)Adh-nBR127 (Fossett et al., 1994) Df(2L)Adh-nBR128 (Fossett et al., 1994) Df(2L)Adh-nBR129 (Fossett et al., 1994) Df(2L)Adh-nBR130 (Fossett et al., 1994) Df(2L)Adh-nBR131 (Fossett et al., 1994) Df(2L)ARR1 (Ashburner et al., 1990) Df(2L)b80e4 (Ashburner et al., 1990) Df(2L)el20 (Ashburner et al., 1990) Df(2L)el28 (Ashburner et al., 1990) Df(2L)fn12 (Ashburner et al., 1990) Df(2L)fn27 (Ashburner et al., 1990) Df(2L)H20 (Ashburner et al., 1990) Df(2L)k05007-mr2 (Roote, 2000.6.13) Df(2L)k05007-mr3 (Roote, 2000.6.13) Df(2L)k05007-mr6 (Roote, 2000.6.13) Df(2L)k05007-mr9 (Roote, 2000.6.13) Df(2L)k05007-mr13 (Roote, 2000.6.13) Df(2L)k09033-mr9 (Roote, 2000.6.13) Df(2L)k09033-mr19 (Roote, 2000.6.13) Df(2L)noc11 (Ashburner et al., 1990) Df(2L)osp38 (Ashburner et al., 1990) Df(2L)PZ05271-mr33 (Roote, 2000.6.13) Df(2L)RA5 (Ashburner et al., 1990, Roote, 1996.8) Df(2L)rd9 (Ashburner et al., 1990) Df(2L)RM5 (Ashburner et al., 1990) Df(2L)RN2 (Ashburner et al., 1990) Df(2L)Scorv19 (Ashburner et al., 1990) Df(2L)Scorv25 (Ashburner et al., 1990) Df(2L)TE35BC-3 (Ashburner et al., 1990) Df(2L)TE35BC-4 (Ashburner et al., 1990) Df(2L)TE35BC-34 (Ashburner et al., 1990, Roote, 1996.8) Df(2L)TE35D-1 (Ashburner et al., 1990) Df(2L)TE35D-4 (Ashburner et al., 1990) Df(2L)TE35D-15 (Ashburner et al., 1990) Df(2L)TE35D-20 (Ashburner et al., 1990) In(2L)75c (BDGP Project Members, 1994-1999) In(2LR)noc4LScorv9R (Cai et al., 2001) In(2LR)Scorv1-DV7 (Ashburner et al., 1990, Roote, 1996.8)
Duplicated in	Dp(2;3)osp3 (Ashburner et al., 1990) In(2L)C163.41LC158R (Ashburner et al., 1990)
Not duplicated in	Dp(2;1)Scorv23 (Ashburner et al., 1990) Dp(2;2)GYL (Ashburner et al., 1990) Dp(2;2)TE35B-54L (Ashburner et al., 1990) In(2L)Scorv17LC158R (Ashburner et al., 1990)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4369} NA P{TRiP.GLV21045} NA P{UAS-wek.C} NA P{UAS-Wek.HA} NA P{UAS-wek.N} NA P{UAS-wek.NM} NA characterization construct P{αTub84B-wek.C} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{PZ}wek05271a No miscellaneous insertions P{3'PZ}wekEX14 NA
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with Myd88 (Chen et al., 2006) inferred from physical interaction with Tl (Chen et al., 2006) protein homodimerization activity inferred from direct assay (Chen et al., 2006)
Biological Process
CV term Evidence References
dorsal/ventral axis specification inferred from mutant phenotype (Chen et al., 2006) maternal specification of dorsal/ventral axis, oocyte, germ-line encoded inferred from mutant phenotype (Luschnig et al., 2004) Toll signaling pathway inferred from mutant phenotype (Chen et al., 2006)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Chen et al., 2006) plasma membrane inferred from direct assay (Chen et al., 2006)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
nucleic acid binding inferred from electronic annotation with InterPro:IPR013087 (FlyBase Curators et al., 2004-) sequence-specific DNA binding transcription factor activity inferred from sequence or structural similarity with EMBL:M36146 (FlyBase, 1992-) zinc ion binding inferred from electronic annotation with InterPro:IPR007087, InterPro:IPR012934, InterPro:IPR015880 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
regulation of transcription, DNA-dependent inferred from sequence or structural similarity with EMBL:M36146 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity with EMBL:M36146 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions wek allele Gene References unspecified cact (Chen et al., 2006) pll (Chen et al., 2006) Tl (Chen et al., 2006) tub (Chen et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 71683 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0001990 DroID - A comprehensive database of gene and protein interactions. • FBgn0001990 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 48785
Orthologs
Genome-wide drosophilid orthologs	Dere\GG24194 Dgri\GH22488 Dmoj\GI22250 Dper\GL24004 Dpse\GA26475 Dsec\GM14198 Dsim\GD21941 Dvir\GJ10853 Dwil\GK14368 Dyak\GE19389
Curated drosophilid orthologs
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • CBP18808 Caenorhabditis briggsae (nematode) RP18101 Caenorhabditis remanei (nematode) RP38949 Caenorhabditis remanei (nematode) ENSCSAVP00000014934 Ciona savignyi (sedentary tunicate) PHUM004964-PA Pediculus humanus (human body louse) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0236733 FBgn0216374 FBgn0198122 FBgn0193356 FBgn0169124 FBgn0247849 FBgn0161594 FBgn0144978 FBgn0129946 FBgn0116326
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	3598 b79a3 wekAM11/CyO, P{sevRas1.V12}FK1 35680 y1 sc* v1; P{TRiP.GLV21045}attP2 30471 b1 wekRAR14 pr1 cn1 bw1/CyO
VDRC	v12706 w1118; P{GD4369}v12706 v12707 w1118; P{GD4369}v12707
Genomic Clones ( 2 )
	BACR06K01 BACR44L22 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 125 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD22579
Other clones	DPiM_LD22579
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD02957 LD38849 LP24312 RE05471 RE06723 RE10810 RE66752
Other clones	98073 155823 214443.26 CK01.8A.C1 CK01.12D.C4 CK01.19D.E4 CK01.44D.G1 CK01.85B.A2 CK01.91B.E3 CK01.103C.C12 EC35076 EK010909 EK013742 EK037419 EK041046 EK050960 EK051411 EK067505 EK067533 EK069705 EK071418 EK085804 EK086844 EK179405 EK220762 EK259244 EK296606 EP18025 EP21611 FGM306E07 RP003009287 RP003018846 RP003021710 RP003030229 RP003033773 RP003087435 RP003093998 RP003110652 RP003124391 RP003135196 RP003141142 RP003144692 RP003156884 RP003158554 RP003162971 RP003173444 RP003194900 RP003196292 RP003200645 RP003205295 RP003208467 RP003228034 RP003250191 RP003250955 RP003255233 RP003257968 RP003269022 RP003270789 RP003271151 RP003272814 RP003274689 RP003281127 RP003296208 RP003296474 RP003297239 RP003300991 RP003305214 RP003305723 RP003308804 RP003312320 RP003320538 RP003325792 RP003327487 RP003327603 RP003327737 RP003328410 RP003329102 RP003332043 RP003332703 RP003343428 RP003343619 RP003347744 RP003357769 RP003375753 RP003390613 RP003407277 RP003416188 RP003423569 RP003427969 RP003452211 RP003481136 RP003505750 RP003515971 RP003520788 RP003521869 RP003523284 RP003544328 RP003544919 RP003554769 RP003559760 RP003562655 RP003571601 RP003578914 RP003599430 RP003600914 RP003602075 RP003611881 RP003624950 RP003625806 RP003634354 RP003638988 RP003651259 RP003656114 RP003658382 RP003658644 RP003663645
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0001990 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 48785
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: wek l(2)35Ea (Luschnig et al., 2004) Source for identity of: wek l(2)35Ea (Luschnig et al., 2004)
Source for database merge of	Source for merge of: l(2)35Ea CG4148 (Misra, 2000.4.12)
Additional comments	Paralogous to CG17568, CG10366 and CG6254. (Chen et al., 2006)
Other Comments
	wek is required for recruitment of the Myd88 protein to the Tl protein. (Chen et al., 2006)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080191 RefSeq (Proteins) • NP_524930 DDBJ / EMBL / GenBank • AA202739 AA817333 AAF44966 AAF53484 AAK93097 AE003414 AI455284 AY051673 Entrez Gene - A searchable database of RefSeq genes. • 48785 UniProtKB/TrEMBL • Q9VJN5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2-like (IPR015880) Zinc finger, C2H2 (IPR007087) Zinc finger, AD-type (IPR012934) Zinc finger, C2H2-type/integrase, DNA-binding (IPR013087)
Linkouts
	BioGRID - A database of protein and genetic interactions • 71683 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0001990 DroID - A comprehensive database of gene and protein interactions. • FBgn0001990 DRSC - Results from RNAi screens. • FBgn0001990 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001990 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4148-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0001990 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 214757 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 48785 InParanoid A subset of ortholog calls from InParanoid. • CBP18808 Caenorhabditis briggsae (nematode) RP18101 Caenorhabditis remanei (nematode) RP38949 Caenorhabditis remanei (nematode) ENSCSAVP00000014934 Ciona savignyi (sedentary tunicate) PHUM004964-PA Pediculus humanus (human body louse) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 48785 modMine - Data generated by the modENCODE project. • FBgn0001990 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • FBgn0236733 FBgn0216374 FBgn0198122 FBgn0193356 FBgn0169124 FBgn0247849 FBgn0161594 FBgn0144978 FBgn0129946 FBgn0116326
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	BG:DS09217.5 (Ashburner et al., 1999.10.12, Ashburner et al., 1999) CG4148 (Brody et al., 2002, Chen et al., 2006, Ni et al., 2011.7.19) l35Ea (Fossett et al., 1994) l(2)35Ea (Spradling et al., 1995, Roote, 2000.7.3, Roote, 1996.1.11, Roote, 1995.3.24, Roote et al., 1996, Gubb et al., 1988, Egger et al., 2002, Cai et al., 2001, BDGP Project Members, 1994-1999, Roote, 2000.6.13, Ashburner et al., 1999, Ashburner et al., 1999, Spradling et al., 1999, Ashburner et al., 1999, Laviolette et al., 2005) l(2)br47 (Ashburner et al., 1990) unnamed (Gates and Thummel, 2000) wek (Chen et al., 2006, Chen, 2006)
Name Synonym	lethal(2)35Ea   weckle (Luschnig et al., 2004, Luschnig et al., 2004, Chen et al., 2006) Weckle (Fu and Levine, 2007, Wei et al., 2005, Fu and Levine, 2008)
Secondary FlyBase IDs
	FBgn0027899 FBgn0032571
References ( 46 )
Generate a list of	All references relating to this gene ( 46 )
List References by type	Research paper  ( 15 ) Supplementary material  ( 7 ) Review  ( 2 ) Personal communication to FlyBase  ( 12 ) Abstract  ( 3 ) FlyBase analysis  ( 1 ) Computer file  ( 2 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 ) Book  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2010 Show research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...