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Gene Dmel\Ca-α1D

General Information
Symbol	Dmel\Ca-α1D	Species	D. melanogaster
Name	Ca2+-channel protein α1 subunit D	Annotation symbol	CG4894
Feature type	protein_coding_gene	FlyBase ID	FBgn0001991
Gene Model Status	Current	Stock availability	11 publicly available
Also Known As	Dmca1D, l(2)35Fa, Ca-alpha1D, Caα1D, BG:DS02795.1
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	35E5-35E6	Sequence location	2L:16,165,831..16,190,540 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Ca2+-channel protein α1 subunit D is referred to in FlyBase by the symbol Dmel\Ca-α1D (CG4894, FBgn0001991). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: voltage-gated calcium channel activity. There is experimental evidence that it is involved in the biological process: epithelial fluid transport. 12 alleles are reported. The phenotypes of these alleles are annotated with: cephalopharyngeal skeleton; NMJ bouton; neuromuscular junction; embryonic/larval tracheal system; longitudinal connective; wing; abdominal segmental nerve. It has 10 annotated transcripts and 10 annotated polypeptides. Protein features are: Ion transport domain; Voltage-dependent calcium channel, L-type, alpha-1 subunit; Voltage-dependent calcium channel, alpha-1 subunit; Voltage-dependent calcium channel, alpha-1 subunit, IQ domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed during late pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult central nervous system, adult heart. Comments on Affy2 ProbeSet: ProbeSet 1640092_a_at completely aligns to an exonic region common to each of the 4 FlyBase-annotated transcript isoforms of Ca-alpha1D. Gene sequence location is 2L:16165831..16190540.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 35E5-35E6   Limits computationally determined from genome sequence between P{lacW}CycEk05007&P{lacW}CycEk02602 and P{EP}crpEP721&P{lacW}crpk07829
Experimentally Determined Cytological Location
Cytogenetic map Notes References 35E3-35F3   (determined by in situ hybridisation)   (Eberl et al., 1998) 35E-35E     (Gellon et al., 1997) 35E-35F   (determined by in situ hybridisation)   (Zheng et al., 1995)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Ca-α1D for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Alternative translation stop created by use of multiphasic reading frames within coding region. Variable use of small exon; supported combination results in frameshift and premature stop in downstream exon. Gene model reviewed during 5.45 Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Ca-α1D-RA FBtr0090006  NM_134429   9425   2516 Ca-α1D-RB FBtr0090005  NM_080365   8973   2519 Ca-α1D-RC FBtr0090004  NM_165146   8986   2552 Ca-α1D-RD FBtr0090003  NM_165147   9298   2300 Ca-α1D-RE FBtr0332020  NM_001273551   8968   2546 Ca-α1D-RF FBtr0332021  NM_001273552   7881   2023 Ca-α1D-RG FBtr0332022  NM_001273553   8226   1799 Ca-α1D-RH FBtr0332023  NM_001273554   7881   2023 Ca-α1D-RI FBtr0332024  NM_001273555   7890   2026 Ca-α1D-RJ FBtr0332025  NM_001273556   8450   2059
Additional Transcript Data & Comments
Reported size (kB)	12.5, 9.5 (northern blot) (Zheng et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Ca-α1D-PA   FBpp0089049   276.7   2516   5.01     NP_602305   AAF53504 Ca-α1D-PB   FBpp0089048   277.1   2519   5.13     NP_525104   AAN10929 Ca-α1D-PC   FBpp0089047   280.7   2552   5.07     NP_723952   AAN10930 Ca-α1D-PD   FBpp0089046   254.6   2300   4.91     NP_723953   AAN10931 Ca-α1D-PE   FBpp0304336   280.8   2546   5.20     NP_001260480   AGB93015 Ca-α1D-PF   FBpp0304337   224.5   2023   6.64     NP_001260481   AGB93016 Ca-α1D-PG   FBpp0304338   201.3   1799   6.40     NP_001260482   AGB93017 Ca-α1D-PH   FBpp0304339   224.6   2023   6.67     NP_001260483   AGB93018 Ca-α1D-PI   FBpp0304340   224.9   2026   6.96     NP_001260484   AGB93019 Ca-α1D-PJ   FBpp0304341   228.5   2059   6.79     NP_001260485   AGB93020
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Voltage-dependent calcium channel, alpha-1 subunit (IPR002077) Voltage-dependent calcium channel, L-type, alpha-1 subunit (IPR005446) Ion transport domain (IPR005821) Voltage-dependent calcium channel, alpha-1 subunit, IQ domain (IPR014873) Voltage-dependent potassium channel, four helix bundle domain (IPR027359)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA567666   AE014134 AAF53504   AE014134 AAN10929   AE014134 AAN10930   AE014134 AAN10931   AE003415 AAF44986   AE014134 AGB93015   AE014134 AGB93016   AE014134 AGB93017   AE014134 AGB93018   AE014134 AGB93019   AE014134 AGB93020   AI062722   AI062792   AI239096   AI401988   AI517535   AW940078   AY058268 AAL13497   BH615004   BT088879   CO178111   CO271778   CO283803   CO285106   CO288656   CO295230   CO297501   CO298786   CO306603   CO321205   CO325829   CO326095   CO326310   CO328910   CO339147   CO340870   CO340962   EC061645   EC062896   EC087072   EC196231   EC207188   EC212979   EC214388   EC221585   EC222802   EC225350   EC228847   EC232795   EC240369   EC240606   EC245515   EC252794   EC257923   EC258225   EC259017   ES690307   EY198942   EY199057   FE527435   FE527455   FE527460   FE527493   FE527595   U00690 AAA81883
UniProtKB/Swiss-Prot	Q24270
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   presumptive embryonic/larval nervous system   (Zheng et al., 1995) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 12 -- 15     (Zheng et al., 1995) Comment:9-12 hr AEL pupal stage | late     (Zheng et al., 1995) adult stage   adult head   (Zheng et al., 1995)   (Zheng et al., 1995)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
apical plasma membrane inferred from direct assay (MacPherson et al., 2001) basolateral plasma membrane inferred from direct assay (MacPherson et al., 2001)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult eye, adult central nervous system, adult heart. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    91.025 Larval Midgut    4.4 Larval Hindgut    20.9 Larval Malpighian Tubules    3.9 Larval Fat Body    5.2 Larval Salivary Gland    6.2 Larval Trachea    12.65 Larval Carcass    91.125 Adult Head    75 Adult Eye    292.05 Adult Brain    428.2 Adult Thoracic-Abdominal Ganglion    295.3 Adult Crop    71.4 Adult Midgut    13.1 Adult Hindgut    53.2 Adult Malpighian Tubules    4.2 Adult Fat Body    6.2 Adult Salivary Gland    10.5 Adult Heart    119.375 Adult VirginFemale Spermatheca    20.7 Adult InseminatedFemale Spermatheca    27.5 Adult Ovary    0.8 Adult Testis    22 Adult Male Accessory Gland    927.1 Adult Carcass    74.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    91.025 Larval Midgut    4.4 Larval Hindgut    20.9 Larval Malpighian Tubules    3.9 Larval Fat Body    5.2 Larval Salivary Gland    6.2 Larval Trachea    12.65 Larval Carcass    91.125 Adult Head    75 Adult Eye    292.05 Adult Brain    428.2 Adult Thoracic-Abdominal Ganglion    295.3 Adult Crop    71.4 Adult Midgut    13.1 Adult Hindgut    53.2 Adult Malpighian Tubules    4.2 Adult Fat Body    6.2 Adult Salivary Gland    10.5 Adult Heart    119.375 Adult VirginFemale Spermatheca    20.7 Adult InseminatedFemale Spermatheca    27.5 Adult Ovary    0.8 Adult Testis    22 Adult Male Accessory Gland  (927.1) Adult Carcass    74.2 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    91.025 Larval Midgut    4.4 Larval Hindgut    20.9 Larval Malpighian Tubules    3.9 Larval Fat Body    5.2 Larval Salivary Gland    6.2 Larval Trachea    12.65 Larval Carcass    91.125 Adult Head    75 Adult Eye    292.05 Adult Brain    428.2 Adult Thoracic-Abdominal Ganglion    295.3 Adult Crop    71.4 Adult Midgut    13.1 Adult Hindgut    53.2 Adult Malpighian Tubules    4.2 Adult Fat Body    6.2 Adult Salivary Gland    10.5 Adult Heart    119.375 Adult VirginFemale Spermatheca    20.7 Adult InseminatedFemale Spermatheca    27.5 Adult Ovary    0.8 Adult Testis    22 Adult Male Accessory Gland    927.1 Adult Carcass    74.2 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    91.025 Larval Midgut    4.4 Larval Hindgut    20.9 Larval Malpighian Tubules    3.9 Larval Fat Body    5.2 Larval Salivary Gland    6.2 Larval Trachea    12.65 Larval Carcass    91.125 Adult Head    75 Adult Eye    292.05 Adult Brain    428.2 Adult Thoracic-Abdominal Ganglion    295.3 Adult Crop    71.4 Adult Midgut    13.1 Adult Hindgut    53.2 Adult Malpighian Tubules    4.2 Adult Fat Body    6.2 Adult Salivary Gland    10.5 Adult Heart    119.375 Adult VirginFemale Spermatheca    20.7 Adult InseminatedFemale Spermatheca    27.5 Adult Ovary    0.8 Adult Testis    22 Adult Male Accessory Gland    927.1 Adult Carcass    74.2 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    91.025 Larval Midgut    4.4 Larval Hindgut    20.9 Larval Malpighian Tubules    3.9 Larval Fat Body    5.2 Larval Salivary Gland    6.2 Larval Trachea    12.65 Larval Carcass    91.125 Adult Head    75 Adult Eye    292.05 Adult Brain    428.2 Adult Thoracic-Abdominal Ganglion    295.3 Adult Crop    71.4 Adult Midgut    13.1 Adult Hindgut    53.2 Adult Malpighian Tubules    4.2 Adult Fat Body    6.2 Adult Salivary Gland    10.5 Adult Heart    119.375 Adult VirginFemale Spermatheca    20.7 Adult InseminatedFemale Spermatheca    27.5 Adult Ovary    0.8 Adult Testis    22 Adult Male Accessory Gland    927.1 Adult Carcass    74.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    91.025 Larval Midgut    4.4 Larval Hindgut    20.9 Larval Malpighian Tubules    3.9 Larval Fat Body    5.2 Larval Salivary Gland    6.2 Larval Trachea    12.65 Larval Carcass    91.125 Adult Head    75 Adult Eye    292.05 Adult Brain    428.2 Adult Thoracic-Abdominal Ganglion    295.3 Adult Crop    71.4 Adult Midgut    13.1 Adult Hindgut    53.2 Adult Malpighian Tubules    4.2 Adult Fat Body    6.2 Adult Salivary Gland    10.5 Adult Heart    119.375 Adult VirginFemale Spermatheca    20.7 Adult InseminatedFemale Spermatheca    27.5 Adult Ovary    0.8 Adult Testis    22 Adult Male Accessory Gland  (927.1) Adult Carcass    74.2 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    91.025 Larval Midgut    4.4 Larval Hindgut    20.9 Larval Malpighian Tubules    3.9 Larval Fat Body    5.2 Larval Salivary Gland    6.2 Larval Trachea    12.65 Larval Carcass    91.125 Adult Head    75 Adult Eye    292.05 Adult Brain    428.2 Adult Thoracic-Abdominal Ganglion    295.3 Adult Crop    71.4 Adult Midgut    13.1 Adult Hindgut    53.2 Adult Malpighian Tubules    4.2 Adult Fat Body    6.2 Adult Salivary Gland    10.5 Adult Heart    119.375 Adult VirginFemale Spermatheca    20.7 Adult InseminatedFemale Spermatheca    27.5 Adult Ovary    0.8 Adult Testis    22 Adult Male Accessory Gland    927.1 Adult Carcass    74.2 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    91.025 Larval Midgut    4.4 Larval Hindgut    20.9 Larval Malpighian Tubules    3.9 Larval Fat Body    5.2 Larval Salivary Gland    6.2 Larval Trachea    12.65 Larval Carcass    91.125 Adult Head    75 Adult Eye    292.05 Adult Brain    428.2 Adult Thoracic-Abdominal Ganglion    295.3 Adult Crop    71.4 Adult Midgut    13.1 Adult Hindgut    53.2 Adult Malpighian Tubules    4.2 Adult Fat Body    6.2 Adult Salivary Gland    10.5 Adult Heart    119.375 Adult VirginFemale Spermatheca    20.7 Adult InseminatedFemale Spermatheca    27.5 Adult Ovary    0.8 Adult Testis    22 Adult Male Accessory Gland    927.1 Adult Carcass    74.2 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    75   NA  Eye    292.05   NA  Brain    428.2   91.025  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    295.3   NA  Crop    71.4   4.4  Midgut    no informative data   20.9  Hindgut    53.2   3.9  Malpighian Tubules    4.2   5.2  Fat Body    6.2   6.2  Salivary Gland    no informative data   NA  Heart    119.375   no informative data  Trachea    NA   NA  VirginFemale Spermatheca    20.7   NA  InseminatedFemale Spermatheca    27.5   NA  Ovary    0.8   NA  Testis    no informative data   NA  Male Accessory Gland    927.1   91.125  Carcass    74.2 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    5 central nervous system, pupae P8    25 head, virgin 1-day female    16 head, virgin 4-day female    17 head, virgin 20-day female    11 head, mated 1-day female    17 head, mated 4-day female    16 head, mated 20-day female    11 head, mated 1-day male    25 head, mated 4-day male    26 head, mated 20-day male    22 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    3 carcass, larvae L3 wandering    3 carcass, 1-day adult    14 carcass, 4-day adult    8 carcass, 20-day adult    5 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    5 central nervous system, pupae P8    25 head, virgin 1-day female    16 head, virgin 4-day female    17 head, virgin 20-day female    11 head, mated 1-day female    17 head, mated 4-day female    16 head, mated 20-day female    11 head, mated 1-day male    25 head, mated 4-day male  26 head, mated 20-day male    22 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    3 carcass, larvae L3 wandering    3 carcass, 1-day adult    14 carcass, 4-day adult    8 carcass, 20-day adult    5 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    5 central nervous system, pupae P8    25 head, virgin 1-day female    16 head, virgin 4-day female    17 head, virgin 20-day female    11 head, mated 1-day female    17 head, mated 4-day female    16 head, mated 20-day female    11 head, mated 1-day male    25 head, mated 4-day male    26 head, mated 20-day male    22 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    3 carcass, larvae L3 wandering    3 carcass, 1-day adult    14 carcass, 4-day adult    8 carcass, 20-day adult    5 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    5 central nervous system, pupae P8    25 head, virgin 1-day female    16 head, virgin 4-day female    17 head, virgin 20-day female    11 head, mated 1-day female    17 head, mated 4-day female    16 head, mated 20-day female    11 head, mated 1-day male    25 head, mated 4-day male    26 head, mated 20-day male    22 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    3 carcass, larvae L3 wandering    3 carcass, 1-day adult    14 carcass, 4-day adult    8 carcass, 20-day adult    5 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    5 central nervous system, pupae P8    25 head, virgin 1-day female    16 head, virgin 4-day female    17 head, virgin 20-day female    11 head, mated 1-day female    17 head, mated 4-day female    16 head, mated 20-day female    11 head, mated 1-day male    25 head, mated 4-day male    26 head, mated 20-day male    22 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    3 carcass, larvae L3 wandering    3 carcass, 1-day adult    14 carcass, 4-day adult    8 carcass, 20-day adult    5 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    5 central nervous system, pupae P8    25 head, virgin 1-day female    16 head, virgin 4-day female    17 head, virgin 20-day female    11 head, mated 1-day female    17 head, mated 4-day female    16 head, mated 20-day female    11 head, mated 1-day male    25 head, mated 4-day male  26 head, mated 20-day male    22 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    3 carcass, larvae L3 wandering    3 carcass, 1-day adult    14 carcass, 4-day adult    8 carcass, 20-day adult    5 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    5 central nervous system, pupae P8    25 head, virgin 1-day female    16 head, virgin 4-day female    17 head, virgin 20-day female    11 head, mated 1-day female    17 head, mated 4-day female    16 head, mated 20-day female    11 head, mated 1-day male    25 head, mated 4-day male    26 head, mated 20-day male    22 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    3 carcass, larvae L3 wandering    3 carcass, 1-day adult    14 carcass, 4-day adult    8 carcass, 20-day adult    5 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    3 central nervous system, larvae L3    5 central nervous system, pupae P8    25 head, virgin 1-day female    16 head, virgin 4-day female    17 head, virgin 20-day female    11 head, mated 1-day female    17 head, mated 4-day female    16 head, mated 20-day female    11 head, mated 1-day male    25 head, mated 4-day male    26 head, mated 20-day male    22 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    1 fat body, pupae P8    3 carcass, larvae L3 wandering    3 carcass, 1-day adult    14 carcass, 4-day adult    8 carcass, 20-day adult    5 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of extremely low expression. Peak expression observed during late pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    2 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    3 embryo 12-14hr    6 embryo 14-16hr    8 embryo 16-18hr    10 embryo 18-20hr    10 embryo 20-22hr    9 embryo 22-24hr    9 larva L1    9 larva L2    6 larva L3 12hr old    6 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    8 pupae 3d postWPP    27 pupae 4d postWPP    14 adult male 01day    15 adult male 05day    13 adult male 30day    11 adult female 01day    7 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    2 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    3 embryo 12-14hr    6 embryo 14-16hr    8 embryo 16-18hr    10 embryo 18-20hr    10 embryo 20-22hr    9 embryo 22-24hr    9 larva L1    9 larva L2    6 larva L3 12hr old    6 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    8 pupae 3d postWPP  (27) pupae 4d postWPP    14 adult male 01day    15 adult male 05day    13 adult male 30day    11 adult female 01day    7 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    2 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    3 embryo 12-14hr    6 embryo 14-16hr    8 embryo 16-18hr    10 embryo 18-20hr    10 embryo 20-22hr    9 embryo 22-24hr    9 larva L1    9 larva L2    6 larva L3 12hr old    6 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    8 pupae 3d postWPP    27 pupae 4d postWPP    14 adult male 01day    15 adult male 05day    13 adult male 30day    11 adult female 01day    7 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    2 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    3 embryo 12-14hr    6 embryo 14-16hr    8 embryo 16-18hr    10 embryo 18-20hr    10 embryo 20-22hr    9 embryo 22-24hr    9 larva L1    9 larva L2    6 larva L3 12hr old    6 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    8 pupae 3d postWPP    27 pupae 4d postWPP    14 adult male 01day    15 adult male 05day    13 adult male 30day    11 adult female 01day    7 adult female 05day    2 adult female 30day    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    2 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    3 embryo 12-14hr    6 embryo 14-16hr    8 embryo 16-18hr    10 embryo 18-20hr    10 embryo 20-22hr    9 embryo 22-24hr    9 larva L1    9 larva L2    6 larva L3 12hr old    6 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    8 pupae 3d postWPP    27 pupae 4d postWPP    14 adult male 01day    15 adult male 05day    13 adult male 30day    11 adult female 01day    7 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    2 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    3 embryo 12-14hr    6 embryo 14-16hr    8 embryo 16-18hr    10 embryo 18-20hr    10 embryo 20-22hr    9 embryo 22-24hr    9 larva L1    9 larva L2    6 larva L3 12hr old    6 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    8 pupae 3d postWPP  27 pupae 4d postWPP    14 adult male 01day    15 adult male 05day    13 adult male 30day    11 adult female 01day    7 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    2 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    3 embryo 12-14hr    6 embryo 14-16hr    8 embryo 16-18hr    10 embryo 18-20hr    10 embryo 20-22hr    9 embryo 22-24hr    9 larva L1    9 larva L2    6 larva L3 12hr old    6 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    8 pupae 3d postWPP    27 pupae 4d postWPP    14 adult male 01day    15 adult male 05day    13 adult male 30day    11 adult female 01day    7 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    2 embryo 06-08hr    1 embryo 08-10hr    2 embryo 10-12hr    3 embryo 12-14hr    6 embryo 14-16hr    8 embryo 16-18hr    10 embryo 18-20hr    10 embryo 20-22hr    9 embryo 22-24hr    9 larva L1    9 larva L2    6 larva L3 12hr old    6 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    2 larva L3 puffstage 7-9    2 white prepupae new    2 white prepupae 12hr    2 white prepupae 24hr    2 pupae 2d postWPP    8 pupae 3d postWPP    27 pupae 4d postWPP    14 adult male 01day    15 adult male 05day    13 adult male 30day    11 adult female 01day    7 adult female 05day    2 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    13 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    4 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    8 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    13 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    4 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    8 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    13 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    4 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    8 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    13 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    4 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    8 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    13 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    4 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    8 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    13 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    4 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    8 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    13 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    4 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    8 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    1 embryonic GM2    0 embryonic Kc167    0 embryonic S1    13 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    4 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    1 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    8 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    4 cold shock, 4-day adult    3 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    10 Ethanol 2.5% 3 hrs, larvae L3    5 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    3 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    4 Paraquat 10 mM 48 hrs, 4-day adult    8 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_15 mE1_20_mRNA_expression_cluster_11
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001991 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4894-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Dcr-2Scer\UAS.cDa, Scer\GAL4e22c, Scer\GAL4sqh.PW Ca-α1DGD1737 lethal | embryonic stage | recessive Ca-α1Dunspecified Ca-α1DX7 Ca-α1DX10 lethal | pharate adult stage | recessive Ca-α1DAR66 lethal | recessive Ca-α1DAR66 Ca-α1DIK2 Ca-α1DX7 Ca-α1DX10 Other Phenotypes Allele neuroanatomy defective Ca-α1DAR66 wild-type Ca-α1D+tCa01 Phenotype manifest in Allele abdominal segmental nerve Ca-α1DAR66 cephalopharyngeal skeleton Ca-α1DX10 Ca-α1DX7 embryonic/larval dorsal vessel | embryonic stage Ca-α1DX10 Ca-α1DX7 embryonic/larval midgut | embryonic stage Ca-α1DX10 Ca-α1DX7 embryonic/larval tracheal system Ca-α1DX10 Ca-α1DX7 longitudinal connective Ca-α1DAR66 neuromuscular junction Ca-α1DAR66 NMJ bouton Ca-α1DAR66 wing Ca-α1DAR66 Ca-α1Dunspecified
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of Ca-α1D Class Mutagen Stocks Known lesion Ca-α1DKG04231 P-element activity 2 -- Ca-α1DX7 ethyl methanesulfonate 2 -- Ca-α1DMB06807 1 -- Ca-α1DX10 ethyl methanesulfonate 1 Yes Ca-α1DAR66 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 Yes Ca-α1DIK2 P-element activity 0 -- Ca-α1DUgra 0 -- Ca-α1Dunspecified 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Ca-α1D Class Mutagen Stocks Known lesion Ca-α1DGD1737 in vitro construct - RNAi in vitro construct - regulatory fusion 3 Yes Ca-α1DHMS00294 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ca-α1DJF01848 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Ca-α1D+tCa01 in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)r10 (Ashburner et al., 1990) Df(2L)RA5 (Eberl et al., 1998, Ashburner et al., 1990, Mahone et al., 1995) Df(2L)RM5 (Ashburner et al., 1990) Df(2L)Scorv16 (Ashraf et al., 1999, Ashburner et al., 1990) Df(2L)TE35BC-24 (Ashraf et al., 1999) Df(2L)TE35D-13 (Eberl et al., 1998, Ashburner et al., 1990) Df(2L)TE35D-16 (Ashburner et al., 1990) Df(2L)TE35D-21 (Ashburner et al., 1990) Df(2L)TE35D-23 (Ashburner et al., 1990) In(2L)el18 (Eberl et al., 1998, Ashburner et al., 1990) Tp(2;2)A446 (Fossett et al., 1994, Roote et al., 1996)
Not disrupted in	Df(2L)64j (Ashburner et al., 1990) Df(2L)A47 (Fossett et al., 1994) Df(2L)A48 (Fossett et al., 1994) Df(2L)A63 (Fossett et al., 1994) Df(2L)A72 (Ashburner et al., 1990, Fossett et al., 1994) Df(2L)A178 (Fossett et al., 1994) Df(2L)A215 (Fossett et al., 1994) Df(2L)A217 (Fossett et al., 1994) Df(2L)A220 (Fossett et al., 1994) Df(2L)A245 (Fossett et al., 1994) Df(2L)A246 (Fossett et al., 1994) Df(2L)A264 (Fossett et al., 1994) Df(2L)A266 (Fossett et al., 1994) Df(2L)A267 (Ashburner et al., 1990, Fossett et al., 1994) Df(2L)A337 (Fossett et al., 1994) Df(2L)A376 (Fossett et al., 1994) Df(2L)A379 (Fossett et al., 1994) Df(2L)A400 (Fossett et al., 1994) Df(2L)A445 (Fossett et al., 1994) Df(2L)Adh-nBR100 (Fossett et al., 1994) Df(2L)Adh-nBR101 (Fossett et al., 1994) Df(2L)Adh-nBR102 (Fossett et al., 1994) Df(2L)Adh-nBR103 (Fossett et al., 1994) Df(2L)Adh-nBR105 (Fossett et al., 1994) Df(2L)Adh-nBR117 (Fossett et al., 1994) Df(2L)Adh-nBR118 (Fossett et al., 1994) Df(2L)Adh-nBR119 (Fossett et al., 1994) Df(2L)Adh-nBR120 (Fossett et al., 1994) Df(2L)Adh-nBR121 (Fossett et al., 1994) Df(2L)Adh-nBR122 (Fossett et al., 1994) Df(2L)Adh-nBR125 (Fossett et al., 1994) Df(2L)Adh-nBR126 (Fossett et al., 1994, Roote, 1996.1.11, Roote, 1996.8) Df(2L)Adh-nBR127 (Fossett et al., 1994) Df(2L)Adh-nBR128 (Fossett et al., 1994) Df(2L)Adh-nBR129 (Fossett et al., 1994) Df(2L)Adh-nBR130 (Fossett et al., 1994) Df(2L)Adh-nBR131 (Fossett et al., 1994) Df(2L)ARR1 (Ashburner et al., 1990) Df(2L)b80e4 (Ashburner et al., 1990) Df(2L)b88b15 (Roote, 1996.8) Df(2L)el20 (Ashburner et al., 1990) Df(2L)el28 (Ashburner et al., 1990) Df(2L)fn12 (Ashburner et al., 1990) Df(2L)fn26 (Ashburner et al., 1990) Df(2L)fn27 (Ashburner et al., 1990) Df(2L)H20 (Ashburner et al., 1990) Df(2L)k09834rv1 (Roote, 2000.6.13) Df(2L)k09834rv2 (Roote, 2000.6.13) Df(2L)n78l3 (Ashburner et al., 1990) Df(2L)noc11 (Ashburner et al., 1990) Df(2L)osp29 (Eberl et al., 1998, Roote, 1996.8) Df(2L)osp38 (Ashburner et al., 1990) Df(2L)rd9 (Ashburner et al., 1990) Df(2L)RN2 (Eberl et al., 1998, Ashburner et al., 1990) Df(2L)Sco7 (Ashburner et al., 1990) Df(2L)Scorv18 (Ashburner et al., 1990) Df(2L)Scorv19 (Ashburner et al., 1990) Df(2L)Scorv25 (Ashburner et al., 1990) Df(2L)SS1 (Ashburner et al., 1990) Df(2L)TE35BC-3 (Ashburner et al., 1990) Df(2L)TE35BC-4 (Ashburner et al., 1990) Df(2L)TE35BC-34 (Ashburner et al., 1990) Df(2L)TE35D-1 (Ashburner et al., 1990) Df(2L)TE35D-2 (Ashburner et al., 1990) Df(2L)TE35D-3 (Ashburner et al., 1990) Df(2L)TE35D-4 (Ashburner et al., 1990) Df(2L)TE35D-6 (Ashburner et al., 1990) Df(2L)TE35D-14 (Eberl et al., 1998, Ashburner et al., 1990) Df(2L)TE35D-15 (Ashburner et al., 1990) Df(2L)TE35D-19 (Ashburner et al., 1990, Roote, 1996.8) Df(2L)TE35D-20 (Ashburner et al., 1990) Df(2L)TE35D-22 (Ashburner et al., 1990) In(2L)dpps22Ldppd36R (Ashburner et al., 1990) In(2LR)Scorv1-DV7 (Ashburner et al., 1990) T(2;3)Scorv7 (Ashburner et al., 1990)
Duplicated in	Dp(2;3)osp3 (Ashburner et al., 1990) Ts(2Lt;4Lt)DTD22+Ts(2Rt;4Rt)TE35B-50 (Roote et al., 1996)
Not duplicated in	Dp(2;1)Scorv23 (Ashburner et al., 1990) Dp(2;2)GYL (Ashburner et al., 1990) Dp(2;2)TE35B-54L (Ashburner et al., 1990) Dp(2;Y)b88b15 (Roote, 1996.8) In(2L)C163.41LC158R (Ashburner et al., 1990) In(2L)Scorv17LC158R (Ashburner et al., 1990)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data characterization construct P{Ca-α1D+Ca01} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}Ca-α1DKG04231 NA insertion of enhancer trap binary system Mi{ET1}Ca-α1DMB06807 No
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
epithelial fluid transport inferred from direct assay AND inferred from expression pattern (MacPherson et al., 2001)
Cellular Component
CV term Evidence References
apical plasma membrane inferred from direct assay (MacPherson et al., 2001) basolateral plasma membrane inferred from direct assay (MacPherson et al., 2001)
Terms Based on Predictions or Assertions ( 6 terms )
Molecular Function
CV term Evidence References
voltage-gated calcium channel activity inferred from electronic annotation with InterPro:IPR002077, InterPro:IPR005446 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Ashburner et al., 1999) non-traceable author statement (Littleton and Ganetzky, 2000, Swiss-Prot Project Members, 1999.7.15)
Biological Process
CV term Evidence References
calcium ion transmembrane transport inferred from electronic annotation with InterPro:IPR002077, InterPro:IPR005446 (FlyBase Curators et al., 2004-) calcium ion transport non-traceable author statement (Littleton and Ganetzky, 2000, Swiss-Prot Project Members, 1999.7.15) embryo development non-traceable author statement (Swiss-Prot Project Members, 1999.7.15) muscle contraction traceable author statement (Littleton and Ganetzky, 2000)
Cellular Component
CV term Evidence References
voltage-gated calcium channel complex inferred from electronic annotation with InterPro:IPR002077 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Ashburner et al., 1999) non-traceable author statement (Littleton and Ganetzky, 2000, MacPherson et al., 2001, Swiss-Prot Project Members, 1999.7.15)
Sequence Ontology: Class of Gene
	gene_with_edited_transcript (Graveley et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Ca-α1D allele Gene References Ca-α1DAR66 Cam (Wang et al., 2003) Ca-α1Dunspecified Dfd (Gellon et al., 1997) Ca-α1DX7 Cam (Wang et al., 2003)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60962 DroID - A comprehensive database of gene and protein interactions. • FBgn0001991 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34950
Orthologs
OrthoDB Orthologs (85) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6KPTW3 Dipteran inclusive ortholog search EOG6CJVR1 Insect inclusive ortholog search EOG6FN3CJ Arthropod inclusive ortholog search EOG6VMCW5 Metazoa inclusive ortholog search EOG6DG2F3
Orthologs in Drosophila Species (EOG6KPTW3)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Ca-α1D     Drosophila simulans   Dsim\GD24041 Y   Drosophila sechellia   Dsec\GM18655 Y   Drosophila erecta   Dere\GG25192 Y   Drosophila yakuba   Dyak\GE21343 Y   Drosophila ananassae   Dana\GF14939     Drosophila pseudoobscura pseudoobscura   Dpse\GA18508 Y   Drosophila persimilis   Dper\GL21044 Y   Drosophila persimilis   Dper\GL21794     Drosophila willistoni   Dwil\GK18110     Drosophila virilis   Dvir\GJ18055 Y   Drosophila mojavensis   Dmoj\GI19648     Drosophila mojavensis   Dmoj\GI17379     Drosophila mojavensis   Dmoj\GI17378     Drosophila grimshawi   Dgri\GH10399 Y
Orthologs in non-Drosophila Dipterans (EOG6CJVR1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL011280   Anopheles gambiae Malaria mosquito  Agam\AGAP012433   Anopheles gambiae Malaria mosquito  Agam\AGAP010295   Anopheles gambiae Malaria mosquito  Agam\AGAP012434   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ018381
Orthologs in non-Dipteran Insects (EOG6FN3CJ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB55481   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG008358   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH13880   Atta cephalotes Leafcutter ant  Acep\ACEP22645   Camponotus floridanus Florida carpenter ant  Cflo\CFLO15491   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19157   Linepithema humile Argentine ant  Lhum\LH18419   Pogonomyrmex barbatus Red harvester ant  Pbar\PB19441   Solenopsis invicta Red fire ant  Sinv\SINV19015   Acyrthosiphon pisum Pea aphid  Apim\ACYPI31143   Bombyx mori Silkmoth  Bmor\BGIBMGA013346   Pediculus humanus Human body louse  Phum\PHUM510590   Tribolium castaneum Red flour beetle  Tcas\TC004715
Orthologs in non-Insect Arthropods (EOG6VMCW5)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\ndhF   Ixodes scapularis Deer tick  Isca\ISCW008837
Orthologs in non-Arthropod Metazoa (EOG6DG2F3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\unc-2 Y Caenorhabditis elegans Nematode  Cele\egl-19 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_007770gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_011692gn Y Danio rerio Zebrafish  Drer\si:ch73-289n4.1 Y Danio rerio Zebrafish  Drer\OTTDARG00000032100 Y Danio rerio Zebrafish  Drer\cacna1ab Y Danio rerio Zebrafish  Drer\cacna1aa Y Danio rerio Zebrafish  Drer\cacna1da Y Danio rerio Zebrafish  Drer\cacna1f Y Danio rerio Zebrafish  Drer\cacna1ba Y Danio rerio Zebrafish  Drer\cacna1r Y Danio rerio Zebrafish  Drer\cacna1sa Y Danio rerio Zebrafish  Drer\cacna1c Y Danio rerio Zebrafish  Drer\ENSDARG00000037904 Y Danio rerio Zebrafish  Drer\cacna1sb Y Danio rerio Zebrafish  Drer\si:ch211-241e1.2 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000031848 Y Xenopus tropicalis Western clawed frog  Xtro\cacna1e Y Xenopus tropicalis Western clawed frog  Xtro\cacna1s Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000033323 Y Xenopus tropicalis Western clawed frog  Xtro\cacna1d Y Xenopus tropicalis Western clawed frog  Xtro\cacna1f Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000033434 Y Xenopus tropicalis Western clawed frog  Xtro\cacna1a Y Gallus gallus Domestic chicken  Ggal\CACNA1B Y Gallus gallus Domestic chicken  Ggal\ENSGALG00000000730 Y Gallus gallus Domestic chicken  Ggal\ENSGALG00000013022 Y Gallus gallus Domestic chicken  Ggal\CACNA1D Y Gallus gallus Domestic chicken  Ggal\CACNA1E Y Mus musculus House mouse  Mmus\Cacna1s Y Mus musculus House mouse  Mmus\Cacna1c Y Mus musculus House mouse  Mmus\Cacna1e Y Mus musculus House mouse  Mmus\Cacna1a Y Mus musculus House mouse  Mmus\Cacna1f Y Mus musculus House mouse  Mmus\ENSMUSG00000015968 Y Mus musculus House mouse  Mmus\Cacna1b Y Rattus norvegicus Norway rat  Rnor\Cacna1a Y Rattus norvegicus Norway rat  Rnor\Cacna1d Y Rattus norvegicus Norway rat  Rnor\Cacna1e Y Rattus norvegicus Norway rat  Rnor\Cacna1c Y Rattus norvegicus Norway rat  Rnor\Cacna1f Y Rattus norvegicus Norway rat  Rnor\Cacna1b Y Homo sapiens Human  Hsap\CACNA1D Y Homo sapiens Human  Hsap\ENSG00000141837 Y Homo sapiens Human  Hsap\CACNA1C Y Homo sapiens Human  Hsap\ENSG00000198216 Y Homo sapiens Human  Hsap\CACNA1B Y Homo sapiens Human  Hsap\CACNA1S Y Homo sapiens Human  Hsap\CACNA1F Y
Human Orthologs (7)
Gene OMIM HGNC Hsap\CACNA1D     Hsap\ENSG00000141837     Hsap\CACNA1C     Hsap\ENSG00000198216     Hsap\CACNA1B     Hsap\CACNA1S     Hsap\CACNA1F
AAA Orthologs (8) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD24041 Drosophila sechellia Dsec\GM18655 Drosophila erecta Dere\GG25192 Drosophila yakuba Dyak\GE21343 Drosophila pseudoobscura pseudoobscura Dpse\GA18508 Drosophila persimilis Dper\GL21044 Drosophila virilis Dvir\GJ18055 Drosophila grimshawi Dgri\GH10399
Stocks & Reagents
Stocks Listed in FlyBase ( 11 )
Bloomington	25830 y1 v1; P{TRiP.JF01848}attP2 25527 w1118; Mi{ET1}Ca-α1DMB06807/SM6a 33413 y1 sc* v1; P{TRiP.HMS00294}attP2 13282 y1; P{SUPor-P}Ca-α1DKG04231/CyO; ry506 4275 b1 Ca-α1DX7 pr1 cn1 wxwxt bw1/CyO 25141 b1 Ca-α1DX10 pr1 cn1 wxwxt bw1/CyO
Kyoto	107664 b1 Ca-α1DX7 pr1 cn1 wxwxt bw1/CyO 114373 yd2 w1118 P{ey-FLP.N}2; P{SUPor-P}Ca-α1DKG04231 P{neoFRT}40A/CyO y+
VDRC	v51491 w1118; P{GD1737}v51491 v51490 w1118; P{GD1737}v51490/CyO v52644 w1118; P{GD1737}v52644/TM3
Genomic Clones ( 2 )
	BACR21C10 BACR39L06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 44 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH02029
Other clones	MIP09644
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH02129 GH04974 GH15274 GH28536 HL01607
Other clones	18950 28093 37334 46005 52941 60037 79108 79382 103094 120121 214405.32 214439.34 214479.28 214501.17 CK01.13A.E10 CK01.17A.A2 CK01.69A.H11 CK01.87B.G4 DMG3-chr2L.1883.pred.a EK055330 EK069058 EK104605 EK164460 EK168224 EK169951 EK173849 EK208958 EK251548 EK290509 EK291641 EP00950 EP02617 EP03227 EP03632 EP11503 EP11637 FE527595
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0001991 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34950
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Ca-α1D CG4894 (Kodira, 1999.11)
Source for database merge of	Source for merge of: Ca-α1 l(2)35Fa (Eberl et al., 1998)
Additional comments
Other Comments
	The Ca-α1D gene product, an α1-subunit of the L-type calcium channel, plays a role in epithelial fluid transport, in a distinct calcium entry mechanism mediated by CAP2b, cGMP and thapsigargin. (MacPherson et al., 2001) Ca-α1D plays a nonredundant, vital role in larvae and adults. (Eberl et al., 1998) Ca-α1D is responsible for the dihyropyridine-sensitive channel in larval muscle but plays no role in the amiloride-sensitive current. (Ren et al., 1998) Identified in a screen for modifiers of the Dfd13/Dfd3 mutant phenotype. Shows no interaction with the Pc mutant phenotype. (Gellon et al., 1997) Identification: Isolated from a Drosophila adult head cDNA library. (Zheng et al., 1995) 14 alleles are discussed but are not named. (Ashburner et al., 1990)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080365 NM_134429 NM_165146 NM_165147 NM_001273551 NM_001273552 NM_001273553 NM_001273554 NM_001273555 NM_001273556 RefSeq (Proteins) • NP_525104 NP_602305 NP_723952 NP_723953 NP_001260480 NP_001260481 NP_001260482 NP_001260483 NP_001260484 NP_001260485 DDBJ / EMBL / GenBank • AA567666 AAA81883 AAF44986 AAF53504 AAL13497 AAN10929 AAN10930 AAN10931 AE003415 AGB93015 AGB93016 AGB93017 AGB93018 AGB93019 AGB93020 AI062722 AI062792 AW940078 AY058268 BH615004 U00690 Entrez Gene - A searchable database of RefSeq genes. • 34950 UniProtKB/Swiss-Prot • Q24270
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Voltage-dependent calcium channel, alpha-1 subunit (IPR002077) Voltage-dependent calcium channel, L-type, alpha-1 subunit (IPR005446) Ion transport domain (IPR005821) Voltage-dependent calcium channel, alpha-1 subunit, IQ domain (IPR014873) Voltage-dependent potassium channel, four helix bundle domain (IPR027359)
Linkouts
	BioGRID - A database of protein and genetic interactions • 60962 DroID - A comprehensive database of gene and protein interactions. • FBgn0001991 DRSC - Results from RNAi screens. • FBgn0001991 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0001991 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4894-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0001991 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34950 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34950 modMine - Data generated by the modENCODE project. • FBgn0001991
Synonyms & Secondary IDs ( 25 )
Reported As
Symbol Synonym	alpha1D (Sénatore et al., 2010) BG:DS02795.1 (Ashburner et al., 1999.10.12, Ashburner et al., 1999) Ca-_1D (Ashburner et al., 1999) Ca-a1D (Ashburner et al., 1999) Ca-alpha1 (Gellon et al., 1997) Ca-alpha1D (Keegan et al., 2005, Scherzer et al., 2003, Pessa et al., 2010, Wasbrough et al., 2010, Meadows et al., 2010) cad (Savva et al., 2012) Ca-α1 (Ashraf et al., 1999, ) Ca-α1D (Tsubouchi et al., 2012, Abruzzi et al., 2011) Caα1D (Bhogal et al., 2011, Jepson and Reenan, 2009, Keegan et al., 2011, Jepson et al., 2011) CG4894 (Schneider et al., 2004, Lin et al., 2010, Perkins et al., 1.15.2009, Pessa et al., 2010, Ni et al., 2010.12.1, Tsubouchi et al., 2012, Praveen et al., 2012) Dmca1D (Rieckhof et al., 2003, MacPherson et al., 2001, Rubin et al., 2000, Littleton and Ganetzky, 2000, Ren et al., 1998, Eberl et al., 1998, Hall et al., 1998, Vecchione et al., 1997, Ren et al., 1997, Chopra et al., 1997, Peixoto et al., 1997, Zheng et al., 1995, Romero et al., 2008, Ryglewski et al., 2012, Worrell and Levine, 2008, Kurshan et al., 2009, Lee and Wu, 2010) DmCa1D (Hoopengardner et al., 2003) DmCa1α1 (Hall et al., 1996) DroCa1 (Eberl et al., 1993) l35Fa (Fossett et al., 1994) l(2)35Fa (Ashburner et al., 1999, Roote, 1996.1.11, Spradling et al., 1995, Mahone et al., 1995, Eberl et al., 1993, Ashburner et al., 1990, ) α1 (Hall et al., 1993) α1D (Jeziorski et al., 2000)
Name Synonym	Ca2+-channel protein alpha1 subunit D (Dimitri et al., 2003) Ca2+-channel protein α1 subunit D (Tsubouchi et al., 2012) Ca2+-channel protein α1 subunit D   Ca2+-channel α1 subunit (Gellon et al., 1997) calcium channel alpha-1 subunit (Hall, 1993.5.25) Drosophila melanogaster calcium channel α1 subunit DHP-sensitive (Eberl et al., 1998)
Secondary FlyBase IDs
	FBgn0004881
References ( 94 )
Generate a list of	All references relating to this gene ( 94 )
List References by type	Research paper  ( 44 ) Supplementary material  ( 7 ) Review  ( 7 ) Personal communication to FlyBase  ( 13 ) Abstract  ( 15 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 3 ) Protein sequence record  ( 1 ) Letter  ( 1 )
Recent research papers ( 7 )
	Praveen et al., 2012, Cell Rep. 1(6): 624--631 A Drosophila Model of Spinal Muscular Atrophy Uncouples snRNP Biogenesis Functions of Survival Motor Neuron from Locomotion and Viability Defects. [FBrf0218971] Ryglewski et al., 2012, J. Physiol. 590(4): 809--825 Cav2 channels mediate low and high voltage-activated calcium currents in Drosophila motoneurons. [FBrf0217496] Savva et al., 2012, Nat. Commun. 3: 790 Auto-regulatory RNA editing fine-tunes mRNA re-coding and complex behaviour in Drosophila. [FBrf0218141] Abruzzi et al., 2011, Genes Dev. 25(22): 2374--2386 Drosophila CLOCK target gene characterization: implications for circadian tissue-specific gene expression. [FBrf0216798] Bhogal et al., 2011, Nat. Neurosci. 14(12): 1517--1524 Modulation of dADAR-dependent RNA editing by the Drosophila fragile X mental retardation protein. [FBrf0216747] Jepson et al., 2011, J. Biol. Chem. 286(10): 8325--8337 Engineered Alterations in RNA Editing Modulate Complex Behavior in Drosophila: REGULATORY DIVERSITY OF ADENOSINE DEAMINASE ACTING ON RNA (ADAR) TARGETS. [FBrf0213236] Keegan et al., 2011, Nucleic Acids Res. 39(16): 7249--7262 Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: loss of ADAR1 in insects. [FBrf0215032] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...