l(2)37Bc, Bc, dZIP7, l(2)E13, l(2)k05424
Gene model reviewed during 5.48
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Catsup using the Feature Mapper tool.
Catsup protein is present in a punctate pattern in the cell body, axonal and dendritic synapses of neurons in the central brain. Colocalisation of Catsup protein with ple protein, or Scer\GAL4ple.PF indicates that many of these neurons are dopaminergic. Expression of Catsup protein in the synapses is indicated by coexpression with Vmat protein.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Catsup in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Catsup is a pleiotropic quantitative trait gene affecting lifespan and locomotor behaviour.
Catsup mutants have significantly elevated ple enzyme activity that may arise from a post-translational modification of the ple enzyme. The hyperactivation of ple enzyme results in abnormally high levels of catecholamines, which can account for the lethality, visible phenotypes and female sterility observed in the mutants.
Mutations in Catsup exhibit morphological defects of the cuticle. Catsup is essential for catecholamine metabolism in cuticle formation. Null and weak alleles of Catsup are semidominant larval lethal that produce variable and pleiotropic phenotypes including promiscuous melanisation of the salivary and lymph glands, extensive regions of incomplete epicuticle development and formation of large melanotic tumours.
Located between coordinates -74.5 and -72.4.
Mutations at the l(2)37Bc locus cause defects in midoogenesis.