FB2021_01, released Feb 18, 2021

Gene: Dmel\Catsup

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General Information
Symbol
Dmel\Catsup
Species
D. melanogaster
Name
Catecholamines up
Annotation Symbol
CG10449
Feature Type
protein_coding_gene
FlyBase ID
FBgn0002022
Gene Model Status
Current
Stock Availability
14 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Also Known As

l(2)37Bc, Bc, dZIP7, l(2)E13, l(2)k05424

Key Links
Genomic Location
Cytogenetic map
37B11-37B11
Sequence location
2L:19,041,862..19,043,614 [+]
Recombination map

2-54

RefSeq locus
NT_033779 REGION:19041862..19043614
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (15 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables enzyme regulator activity
inferred from mutant phenotype
(Stathakis et al., 1999)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables zinc ion transmembrane transporter activity
inferred from biological aspect of ancestor with PANTHER:PTN000424313
(assigned by GO_Central )
(Gaudet et al., 2011)
inferred by curator from GO:0010312
(Lye et al., 2013)
Biological Process (7 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in detoxification of zinc ion
inferred from mutant phenotype
(Lye et al., 2013)
involved_in ovarian nurse cell to oocyte transport
inferred from high throughput mutant phenotype
(Schupbach and Wieschaus, 1991)
involved_in positive regulation of border follicle cell migration
inferred from mutant phenotype
(Wang et al., 2006)
involved_in regulation of catecholamine metabolic process
inferred from mutant phenotype
(Stathakis et al., 1999)
involved_in regulation of epithelial cell migration, open tracheal system
inferred from mutant phenotype
(Hsouna et al., 2007)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in cellular zinc ion homeostasis
inferred from biological aspect of ancestor with PANTHER:PTN000424313
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in zinc ion transmembrane transport
inferred from biological aspect of ancestor with PANTHER:PTN000424313
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (6 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
located_in axon
inferred from direct assay
(Wang et al., 2011)
located_in neuronal cell body
inferred from direct assay
(Wang et al., 2011)
located_in perinuclear endoplasmic reticulum
inferred from direct assay
(Groth et al., 2013)
located_in synapse
inferred from direct assay
(Wang et al., 2011)
located_in synaptic vesicle
inferred from direct assay
(Wang et al., 2011)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in membrane
inferred from electronic annotation with InterPro:IPR003689
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the ZIP transporter (TC 2.A.5) family. KE4/Catsup subfamily. (Q9V3A4)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
SLC39 FAMILY OF ZINC ION TRANSPORTERS -
Solute carrier family 39 (SLC39) or Zinc-Iron Permeases (ZIP) transport Zn2+ across the membrane into the cytosol, either from the extracellular space or from the lumen of intracellular organelles. (Adapted from FBrf0220942).
Protein Function (UniProtKB)
Negatively regulates tyrosine hydroxylase activity.
(UniProt, Q9V3A4)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
l(2)37Bc
Larval lethal. l(2)37Bc1 produces many dead collapsed larvae at 48 h; l(2)37Bc20 displays small, still-living larvae at 144 h; l(2)37Bc11 pupal lethal with melanized puparia and pharate adults, with incomplete head and thoracic cuticle, no abdominal cuticle, and no eyes or bristles. Melanotic tumors in l(2)37Bc9/l(2)37Bc20 and l(2)37Bc9/l(2)37Bcfs1 adults.
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Catsup for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.48

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Catsup-RA
FBtr0081143
NM_080192
1698
449
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Catsup-PA
FBpp0080687
48.7
449
6.87
NP_524931
AAF53744
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Catsup using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult brain | restricted
(Wang et al., 2011)
dopaminergic neuron | subset of adult brain
(Wang et al., 2011)
dopaminergic neuron | subset of adult brain
(Wang et al., 2011)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data

Catsup protein is present in a punctate pattern in the cell body, axonal and dendritic synapses of neurons in the central brain. Colocalisation of Catsup protein with ple protein, or Scer\GAL4ple.PF indicates that many of these neurons are dopaminergic. Expression of Catsup protein in the synapses is indicated by coexpression with Vmat protein.

(Wang et al., 2011)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in axon
inferred from direct assay
(Wang et al., 2011)
located_in neuronal cell body
inferred from direct assay
(Wang et al., 2011)
located_in perinuclear endoplasmic reticulum
inferred from direct assay
(Groth et al., 2013)
located_in synapse
inferred from direct assay
(Wang et al., 2011)
located_in synaptic vesicle
inferred from direct assay
(Wang et al., 2011)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Catsup in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 59 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 17 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Catsup
Transgenic constructs containing regulatory region of Catsup
Aberrations (Deficiencies and Duplications) ( 33 )
Inferred from experimentation
Gene disrupted in
Df(2L)BSC257
(Christensen and Cook, 2007.3.22)
Df(2L)BSC341
(Christensen and Cook, 2007.10.29)
Df(2L)Catsup44
(Stathakis et al., 1999)
Df(2L)Catsup45
(Stathakis et al., 1999)
Df(2L)Catsup46
(Stathakis et al., 1999)
Df(2L)E71
(Wright et al., 1981)
Df(2L)Exel6042
(Ryder, 2004.4.26)
Df(2L)Exel8039
(Ryder, 2004.4.26)
Df(2L)hk18
(Wright, 1996, Pentz et al., 1986)
Df(2L)hk-UC1
(Wright, 1996, Stathakis et al., 1995, BDGP Project Members, 1994-1999)
Df(2L)hk-UC2
(Wright, 1996, Stathakis et al., 1995)
Df(2L)OD15
(Stathakis et al., 1999, Thor and Thomas, 1997, Wright, 1996, Stathakis et al., 1995, BDGP Project Members, 1994-1999, Pentz et al., 1986)
Df(2L)TW50
(Spradling et al., 1999, BDGP Project Members, 1994-1999, Wright et al., 1976)
Df(2L)TW130
(Stathakis et al., 1999, Wright, 1996, Stathakis et al., 1995, Wright et al., 1981, Wright et al., 1976)
Df(2L)VA18
(Wright, 1996, Stathakis et al., 1995, Pentz et al., 1986, Gilbert et al., 1984)
Df(2L)VA21
(Wright, 1996, Stathakis et al., 1995)
Df(2L)VA23
(Stathakis et al., 1995)
Gene not disrupted in
Df(2L)E55
(Stathakis et al., 1995)
Df(2L)M36F-S5
(BDGP Project Members, 1994-1999)
Df(2L)NST
(Wright, 1996, Stathakis et al., 1995, Pentz et al., 1986)
Df(2L)Sd37
(Wright, 1996, Stathakis et al., 1995)
Df(2L)Sd57
(Wright, 1996, Stathakis et al., 1995)
Df(2L)Sd77
(Wright, 1996, Stathakis et al., 1995)
Df(2L)TE37C-1
(Wright, 1996, Gilbert et al., 1984, Wright et al., 1981)
Df(2L)TE37C-7
(Wright, 1996, Stathakis et al., 1995)
Df(2L)TW3
(Thor and Thomas, 1997, BDGP Project Members, 1994-1999)
Df(2L)TW65
(BDGP Project Members, 1994-1999)
Df(2L)TW137
(Stathakis et al., 1995, BDGP Project Members, 1994-1999)
Df(2L)TW203
(Wright, 1996, Stathakis et al., 1995, BDGP Project Members, 1994-1999, Pentz et al., 1986)
Df(2L)VA12
(Wright, 1996, Stathakis et al., 1995, Pentz et al., 1986, Gilbert et al., 1984, Wright et al., 1981)
Df(2L)VA13
(Wright, 1996, Gilbert et al., 1984, Wright et al., 1981)
Df(2L)VA17
(Wright, 1996, Stathakis et al., 1995, BDGP Project Members, 1994-1999, Pentz et al., 1986, Gilbert et al., 1984, Wright et al., 1981)
Df(2L)VA19
(Wright, 1996, Stathakis et al., 1995)
Inferred from location
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4Act5C.PU
lethal, with Scer\GAL4GMR.PF, Scer\GAL4ey.PH
lethal, with Scer\GAL4Mef2.PR
lethal, with Scer\GAL4pnr-MD237
lethal (with Catsup26)
lethal (with Catsup47)
lethal (with Catsup48)
lethal | male, with Scer\GAL4Bx-MS1096
lethal | recessive
lethal | recessive | cold sensitive
lethal | recessive | heat sensitive
lethal - all die before end of larval stage
lethal - all die before end of larval stage | recessive
lethal - all die before end of pupal stage | recessive
lethal - all die during first instar larval stage
lethal - all die during larval stage, with Scer\GAL4Tub.PU
partially lethal, with Scer\GAL4tin.CΔ4
partially lethal - majority die | female, with Scer\GAL4Bx-MS1096
partially lethal - majority die | recessive
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Tub.PU
Sterility
Allele
female fertile
female sterile
female sterile | recessive
Other Phenotypes
Allele
abnormal body color, with Scer\GAL4pnr-MD237
abnormal grooming behavior | adult stage | dominant
chemical resistant | adult stage | dominant
hyperactive | adult stage | dominant
melanotic mass phenotype
melanotic mass phenotype | dominant
some die during larval stage
some die during larval stage | recessive
some die during pupal stage, with Scer\GAL4pnr-MD237
some die during pupal stage | recessive
visible, with Scer\GAL4pnr-MD237
visible | recessive | somatic clone
wild-type
Phenotype manifest in
Allele
adult cuticle
adult cuticle & abdomen
adult cuticle & adult abdomen
adult thorax, with Scer\GAL4pnr-MD237
border follicle cell | somatic clone
crystal cell
dorsal appendage
dorsal appendage | germline clone
egg | germline clone
embryonic/larval dorsal trunk
embryonic/larval fat body | third instar larval stage, with Scer\GAL4SPARC-MI00329-GAL4
embryonic/larval salivary gland | embryonic stage
embryonic/larval tracheal system
epidermis | pharate adult stage
extracellular matrix | third instar larval stage, with Scer\GAL4SPARC-MI00329-GAL4
eye
hemolymph
macrochaeta
macrochaeta & adult abdomen
melanotic mass
pupal cuticle
tergite
wing, with Scer\GAL4Bx-MS1096
wing blade | somatic clone
wing margin | somatic clone
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (10)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\SLC39A7
14 of 15
Yes
Yes
2  
Hsap\SLC39A13
4 of 15
No
No
1  
Hsap\SLC39A4
2 of 15
No
No
1  
Hsap\SLC39A5
2 of 15
No
No
1  
Hsap\SLC39A6
2 of 15
No
No
2  
Hsap\SLC39A8
2 of 15
No
No
1  
Hsap\SLC39A10
2 of 15
No
No
Hsap\SLC39A12
2 of 15
No
No
1  
Hsap\SLC39A14
2 of 15
No
No
Hsap\SLC39A11
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (10)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Slc39a7
14 of 15
Yes
Yes
Mmus\Slc39a13
4 of 15
No
No
Mmus\Slc39a4
2 of 15
No
No
Mmus\Slc39a5
2 of 15
No
No
Mmus\Slc39a6
2 of 15
No
No
Mmus\Slc39a8
2 of 15
No
No
Mmus\Slc39a12
2 of 15
No
No
Mmus\Slc39a14
2 of 15
No
No
Mmus\Slc39a10
1 of 15
No
No
Mmus\Slc39a11
1 of 15
No
No
Rattus norvegicus (Norway rat) (10)
Rnor\Slc39a7
12 of 13
Yes
Yes
Rnor\Slc39a13
3 of 13
No
No
Rnor\Slc39a4
2 of 13
No
No
Rnor\Slc39a5
2 of 13
No
No
Rnor\Slc39a6
2 of 13
No
No
Rnor\Slc39a8
2 of 13
No
No
Rnor\Slc39a10
2 of 13
No
No
Rnor\Slc39a12
2 of 13
No
No
Rnor\Slc39a14
2 of 13
No
No
Rnor\Slc39a11
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (10)
Xtro\slc39a7
7 of 12
Yes
Yes
Xtro\slc39a13
3 of 12
No
No
Xtro\slc39a4
2 of 12
No
No
Xtro\slc39a5
2 of 12
No
No
Xtro\slc39a6
2 of 12
No
No
Xtro\slc39a8
2 of 12
No
Yes
Xtro\slc39a10
2 of 12
No
No
Xtro\slc39a12
2 of 12
No
Yes
Xtro\slc39a14
2 of 12
No
No
Xtro\slc39a11
1 of 12
No
No
Danio rerio (Zebrafish) (9)
Drer\slc39a7
13 of 15
Yes
Yes
Drer\slc39a13
3 of 15
No
No
Drer\slc39a4
2 of 15
No
No
Drer\slc39a5
2 of 15
No
No
Drer\slc39a6
2 of 15
No
No
Drer\slc39a8
2 of 15
No
No
Drer\slc39a10
2 of 15
No
No
Drer\LOC103908772
1 of 15
No
Yes
Drer\slc39a14
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (7)
Cele\zipt-7.2
13 of 15
Yes
Yes
Cele\zipt-7.1
9 of 15
No
Yes
Cele\zipt-13
4 of 15
No
No
Cele\zipt-17
3 of 15
No
No
Cele\zipt-15
2 of 15
No
No
Cele\zipt-16
2 of 15
No
No
Cele\zipt-11
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (1)
Atha\IAR1
8 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\YKE4
11 of 15
Yes
Yes
Scer\ZRT3
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\SPAP8A3.03
10 of 12
Yes
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190E3I )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00001243
Drosophila simulans
Dsim\Catsup
Drosophila sechellia
Dsec\GM17316
Drosophila erecta
Dere\GG21151
Drosophila yakuba
Dyak\GE13224
Drosophila ananassae
Dana\GF14692
Drosophila pseudoobscura pseudoobscura
Dpse\GA10324
Drosophila persimilis
Dper\GL18911
Drosophila willistoni
Dwil\GK24165
Drosophila virilis
Dvir\GJ11603
Drosophila mojavensis
Dmoj\GI13064
Drosophila grimshawi
Dgri\GH10891
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150AQ0 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17008644
Glossina morsitans
Tsetse fly
Gmor\GMOY007302
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_08986
Mayetiola destructor
Hessian fly
Mdes\Mdes007661
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL001968
Anopheles darlingi
American malaria mosquito
Adar\ADAC003460
Anopheles gambiae
Malaria mosquito
Agam\AGAP008034
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ008087
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0CZI )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA002971
Danaus plexippus
Monarch butterfly
Dple\DPOGS211091-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL012482
Apis florea
Little honeybee
Aflo\2435952868
Apis mellifera
Western honey bee
Amel\GB48408
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP10796
Bombus terrestris
Buff-tailed bumblebee
Bter\15213516
Linepithema humile
Argentine ant
Lhum\LH22473
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:002577
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003725
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06052
Tribolium castaneum
Red flour beetle
Tcas\TC013479
Pediculus humanus
Human body louse
Phum\PHUM463380
Rhodnius prolixus
Kissing bug
Rpro\ZIP13
Cimex lectularius
Bed bug
Clec\CLEC005158
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004908
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_07646
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0CXF )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR013598
Ixodes scapularis
Black-legged tick
Isca\ISCW017090
Stegodyphus mimosarum
African social velvet spider
Smim\KFM81791.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g01790
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_220710
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0GD1 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc39a13
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Slc39a7
Ciona intestinalis
Vase tunicate
Cint\LOC100177251
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000023228
Gallus gallus
Domestic chicken
Ggal\SLC39A13
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (4)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Zip99C
7 of 10
foi
3 of 10
Zip71B
3 of 10
Zip48C
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SLC39A7; solute carrier family 39 member 7
    14 of 15
    601416
         
        SLC39A13; solute carrier family 39 member 13
        4 of 15
        608735
         
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        Catsup - Pu
        anti bait coimmunoprecipitation, western blot, two hybrid
        (Wang et al., 2011)
        Catsup - ple
        two hybrid, anti bait coimmunoprecipitation, western blot
        (Wang et al., 2011)
        Summary of Genetic Interactions
        esyN Network Diagram
        esyN Network Key:
        Suppression
        Enhancement
        View in Interactions Browser
        Please look at the allele data for full details of the genetic interactions
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Catsup
        suppressible
        awd
        (Hsouna et al., 2007)
        Catsup
        enhanceable
        btl
        (Hsouna et al., 2007)
        Catsup
        suppressible
        Pu
        (Hsouna et al., 2007)
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        awd
        suppressible
        Catsup
        (Hsouna et al., 2007)
        N
        enhanceable
        Catsup
        (Groth et al., 2013)
        Pu
        suppressible
        Catsup
        (Hsouna et al., 2007)
        Zip42C.1|ZnT63C
        enhanceable
        Catsup
        (Lye et al., 2013)
        Zip42C.1|ZnT63C
        suppressible
        Catsup
        (Lye et al., 2013)
        Zip71B
        suppressible
        Catsup
        (Dechen et al., 2015)
        Zip71B
        enhanceable
        Catsup
        (Dechen et al., 2015)
        ZnT86D
        enhanceable
        Catsup
        (Dechen et al., 2015)
        ZnT86D
        suppressible
        Catsup
        (Dechen et al., 2015)
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2L
        Recombination map

        2-54

        Cytogenetic map
        37B11-37B11
        Sequence location
        2L:19,041,862..19,043,614 [+]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        37B11-37B11
        Limits computationally determined from genome sequence between P{lacW}l(2)37Dbk16106&P{lacW}Catsupk05424 and P{lacW}Ddck02104
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        37B7-37B10
        (determined by in situ hybridisation)
        (Spradling et al., 1999)
        37B10-37B10
        (determined by in situ hybridisation)
        (Wright, 1991)
        37B8-37B12
        37B7--10
        (BDGP Project Members, 1994-1999)
        Experimentally Determined Recombination Data
        Location

        2-54

        (FlyBase, 2016)

        2-53.6

        (Comeron et al., 2012)

        2-53.9

        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (14)
        Genomic Clones (24)
        cDNA Clones (56)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of
          Source for database merge of

          Source for merge of: Catsup CG10449

          (Bayraktaroglu, 2000.8.7)

          Source for merge of: Catsup l(2)k05424

          (FlyBase, 1996-)
          Additional comments

          Source for merge of Catsup l(2)k05424 was a shared cDNA ( date:030206 ).

          (FlyBase, 1996-)
          Other Comments

          Loss of function of Catsup results in abnormal accumulation of membrane proteins (including N, Egfr and Appl) in he secretory compartment of wing imaginal disc cells.

          (Groth et al., 2013)

          Catsup is a pleiotropic quantitative trait gene affecting lifespan and locomotor behaviour.

          (Carbone et al., 2006)

          Catsup mutants have significantly elevated ple enzyme activity that may arise from a post-translational modification of the ple enzyme. The hyperactivation of ple enzyme results in abnormally high levels of catecholamines, which can account for the lethality, visible phenotypes and female sterility observed in the mutants.

          (Stathakis et al., 1999)

          Mutations in Catsup exhibit morphological defects of the cuticle. Catsup is essential for catecholamine metabolism in cuticle formation. Null and weak alleles of Catsup are semidominant larval lethal that produce variable and pleiotropic phenotypes including promiscuous melanisation of the salivary and lymph glands, extensive regions of incomplete epicuticle development and formation of large melanotic tumours.

          (Stathakis et al., 1995)

          Located between coordinates -74.5 and -72.4.

          (Stathakis et al., 1995)

          Mutations at the l(2)37Bc locus cause defects in midoogenesis.

          (Schupbach and Wieschaus, 1991)
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 424 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
          Other crossreferences
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          modMine - A data warehouse for the modENCODE project
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          FlyMine - An integrated database for Drosophila genomics
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          Synonyms and Secondary IDs (18)
          Reported As
          Symbol Synonym
          Bc
          (Thor and Thomas, 1997, Wright, 1996, McCrady and Tolin, 1994)
          CATSUP
          (Richards and Burke, 2016)
          CG10449
          (Yin et al., 2017, Richards and Burke, 2016, Xiao and Zhou, 2016, Hosono et al., 2015, Ni et al., 2010.12.1, Keleman et al., 2009.8.5)
          Catecholamines up
          (Edwards et al., 2006)
          Catsup
          (Billmann et al., 2018, Carrasco-Rando et al., 2016, Sarov et al., 2016, Morozova et al., 2015, Ryoo, 2015, Groth et al., 2013, Lye et al., 2013, Qin et al., 2013, Inamdar et al., 2012, Loeschcke et al., 2011, Wang et al., 2011, Gutiérrez et al., 2010, Harbison et al., 2009, Carrasco-Rando and Ruiz-Gómez, 2008, Ferdousy et al., 2008, Wicker-Thomas and Hamann, 2008, Wright and O'Donnell, 2008, Chaudhuri et al., 2007, Christensen and Cook, 2007.3.22, Christensen and Cook, 2007.10.29, Dietzl et al., 2007, Ferdousy et al., 2007, Hsouna et al., 2007, Inamdar et al., 2007, Roshina and Pasyukova, 2007, Carbone et al., 2006, Jordan et al., 2006, McCrady and Tolin, 1994)
          ZipCatsup
          (Richards et al., 2017)
          catsup
          (Calap-Quintana et al., 2017, Yin et al., 2017, Xiao and Zhou, 2016, Riveron et al., 2013, Lye et al., 2012, Lye et al., 2012, Muñoz-Soriano and Paricio, 2011, Norry et al., 2009, Wang et al., 2006)
          cg10449
          (Lye et al., 2012)
          dCATSUP
          (Mathews et al., 2005)
          dZIP7
          (Zhao and Zhou, 2020, Xu et al., 2019)
          dZipCATSUP
          (Dechen et al., 2015)
          dZipCatsup
          (Dechen et al., 2015)
          fs(2)ltoQT50
          l(2)37Bc
          (Thor et al., 1999, Lemaitre et al., 1995, Stathakis et al., 1995, Wright, 1987, Pentz et al., 1986, Gilbert et al., 1984, Wright et al., 1981)
          l(2)E13
          (Wright et al., 1976)
          l(2)k05402
          (Mesilaty-Gross et al., 1999)
          l(2)k05424
          (Spradling et al., 1999)
          Name Synonyms
          Catecholamines up
          (Groth et al., 2013, Inamdar et al., 2012, Gutiérrez et al., 2010, Harbison et al., 2009, Ferdousy et al., 2008, Wright and O'Donnell, 2008, Hsouna et al., 2007, Carbone et al., 2006, Edwards et al., 2006, Jordan et al., 2006)
          catecholamines up
          (Richards and Burke, 2016)
          catsup
          (Edwards and Mackay, 2004)
          Secondary FlyBase IDs
          • FBgn0022172
          • FBgn0032743
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (119)