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Gene Dmel\Catsup

General Information
Symbol	Dmel\Catsup	Species	D. melanogaster
Name	Catecholamines up	Annotation symbol	CG10449
Feature type	protein_coding_gene	FlyBase ID	FBgn0002022
Gene Model Status	Current	Stock availability	10 publicly available
Also Known As	l(2)37Bc, Bc
Genomic Location
Chromosome (arm)	2L	Recombination map	2-53.9
Cytogenetic map	37B11-37B11	Sequence location	2L:19,041,714..19,043,614 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Catecholamines up is referred to in FlyBase by the symbol Dmel\Catsup (CG10449, FBgn0002022). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: enzyme regulator activity. There is experimental evidence that it is involved in the biological process: regulation of catecholamine metabolic process; ovarian nurse cell to oocyte transport; regulation of epithelial cell migration, open tracheal system. 63 alleles are reported. The phenotypes of these alleles are annotated with: hemolymph; eye; macrochaeta; adult cuticle; wing; tergite; dorsal appendage; melanotic mass; crystal cell; pupal cuticle. It has one annotated transcript and one annotated polypeptide. Protein features are: Zinc/iron permease. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult midgut, larval/adult Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval midgut, larval/adult hindgut, adult heart, adult fat body, adult ovary, adult testis, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1627458_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Catsup. Gene sequence location is 2L:19041714..19043614.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	l(2)37Bc Larval lethal. l(2)37Bc1 produces many dead collapsed larvae at 48 h; l(2)37Bc20 displays small, still-living larvae at 144 h; l(2)37Bc11 pupal lethal with melanized puparia and pharate adults, with incomplete head and thoracic cuticle, no abdominal cuticle, and no eyes or bristles. Melanotic tumors in l(2)37Bc9/l(2)37Bc20 and l(2)37Bc9/l(2)37Bcfs1 adults.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features BKN23822 HFA03288
FB2011_10	References Loeschcke et al., 2011, J. Insect Physiol. 57(9): 1227--1231
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 37B11-37B11   Limits computationally determined from genome sequence between P{lacW}l(2)37Dbk16106&P{lacW}Catsupk05424 and P{lacW}Ddck02104
Experimentally Determined Cytological Location
Cytogenetic map Notes References 37B7-37B10   (determined by in situ hybridisation)   (Spradling et al., 1999) 37B10-37B10   (determined by in situ hybridisation)   (Wright, 1991) 37B8-37B12   37B7--10   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	2-53.9
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Catsup for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Catsup-RA FBtr0081143  NM_080192   1846   449
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Catsup-PA   FBpp0080687   48.7   449   6.87     NP_524931   AAF53744
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc/iron permease (IPR003689)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA536281   AA816541   AA817564   AA940755   AA950040   AA950153   AA950354   AE014134 AAF53744   AF216584 AAF37226   AI108788   AI108794   AI108975   AI455330   AI455732   AQ025760   AY058528 AAL13757   BF494698   BG637374   BG641380   BI170684   BI212344   BI212959   BI228092   BI231437   BI236022   BI240441   BI356201   BI361637   BI362215   BI362339   BI362560   BI362561   BI362948   BI368890   BI374085   BI639757   BP541863   CA804332   CK658279   CO182625   CO185151   CO189824   CO303996   CO311946   CO322789   CO328507   CO331646   CO336503   CO338118   CZ475990   DQ375815 ABD37706   DQ375816 ABD37707   DQ375817 ABD37708   DQ375818 ABD37709   DQ375819 ABD37710   DQ375820 ABD37711   DQ375821 ABD37712   DQ375822 ABD37713   DQ375823 ABD37714   DQ375824 ABD37715   DQ375825 ABD37716   DQ375826 ABD37717   DQ375827 ABD37718   DQ375828 ABD37719   DQ375829 ABD37720   DQ375830 ABD37721   DQ375831 ABD37722   DQ375832 ABD37723   DQ375833 ABD37724   DQ375834 ABD37725   DQ375835 ABD37726   DQ375836 ABD37727   DQ375837 ABD37728   DQ375838 ABD37729   DQ375839 ABD37730   DQ375840 ABD37731   DQ375841 ABD37732   DQ375842 ABD37733   DQ375843 ABD37734   DQ375844 ABD37735   DQ375845 ABD37736   DQ375846 ABD37737   DQ375847 ABD37738   DQ375848 ABD37739   DQ375849 ABD37740   DQ375850 ABD37741   DQ375851 ABD37742   DQ375852 ABD37743   DQ375853 ABD37744   DQ375854 ABD37745   DQ375855 ABD37746   DQ375856 ABD37747   DQ375857 ABD37748   DQ375858 ABD37749   DQ375859 ABD37750   DQ375860 ABD37751   DQ375861 ABD37752   DQ375862 ABD37753   DQ375863 ABD37754   DQ375864 ABD37755   DQ375865 ABD37756   DQ375866 ABD37757   DQ375867 ABD37758   DQ375868 ABD37759   DQ375869 ABD37760   DQ375870 ABD37761   DQ375871 ABD37762   DQ375872 ABD37763   DQ375873 ABD37764   DQ375874 ABD37765   DQ375875 ABD37766   DQ375876 ABD37767   DQ375877 ABD37768   DQ375878 ABD37769   DQ375879 ABD37770   DQ375880 ABD37771   DQ375881 ABD37772   DQ375882 ABD37773   DQ375883 ABD37774   DQ375884 ABD37775   DQ375885 ABD37776   DQ375886 ABD37777   DQ375887 ABD37778   DQ375888 ABD37779   DQ375889 ABD37780   DQ375890 ABD37781   DQ375891 ABD37782   DQ375892 ABD37783   DQ375893 ABD37784   DQ375894 ABD37785   DQ375895 ABD37786   DQ375896 ABD37787   DQ375897 ABD37788   DQ375898 ABD37789   DQ375899 ABD37790   DQ375900 ABD37791   DQ375901 ABD37792   DQ375902 ABD37793   DQ375903 ABD37794   DQ375904 ABD37795   DQ375905 ABD37796   DQ375906 ABD37797   DQ375907 ABD37798   DQ375908 ABD37799   DQ375909 ABD37800   DQ375910 ABD37801   DQ375911 ABD37802   DQ375912 ABD37803   DQ375913 ABD37804   DQ375914 ABD37805   DQ375915 ABD37806   DQ375916 ABD37807   DQ375917 ABD37808   DQ375918 ABD37809   DQ375919 ABD37810   DQ375920 ABD37811   DQ375921 ABD37812   DQ375922 ABD37813   DQ375923 ABD37814   DQ375924 ABD37815   DQ375925 ABD37816   DQ375926 ABD37817   DQ375927 ABD37818   DQ375928 ABD37819   DQ375929 ABD37820   DQ375930 ABD37821   DQ375931 ABD37822   DQ375932 ABD37823   DQ375933 ABD37824   DQ375934 ABD37825   DQ375935 ABD37826   DQ375936 ABD37827   DQ375937 ABD37828   DQ375938 ABD37829   DQ375939 ABD37830   DQ375940 ABD37831   DQ375941 ABD37832   DQ375942 ABD37833   DQ375943 ABD37834   DQ375944 ABD37835   DQ375945 ABD37836   DQ375946 ABD37837   DQ375947 ABD37838   DQ375948 ABD37839   DQ375949 ABD37840   DQ375950 ABD37841   DQ375951 ABD37842   DQ375952 ABD37843   DQ375953 ABD37844   DQ375954 ABD37845   DQ375955 ABD37846   DQ375956 ABD37847   DQ375957 ABD37848   DQ375958 ABD37849   DQ375959 ABD37850   DQ375960 ABD37851   DQ375961 ABD37852   DQ375962 ABD37853   DQ375963 ABD37854   DQ375964 ABD37855   DQ375965 ABD37856   DQ375966 ABD37857   DQ375967 ABD37858   DQ375968 ABD37859   DQ375969 ABD37860   DQ375970 ABD37861   DQ375971 ABD37862   DQ375972 ABD37863   DQ375973 ABD37864   DQ375974 ABD37865   DQ375975 ABD37866   DQ375976 ABD37867   DQ375977 ABD37868   DQ375978 ABD37869   DQ375979 ABD37870   DQ375980 ABD37871   DQ375981 ABD37872   DQ375982 ABD37873   DQ375983 ABD37874   DQ375984 ABD37875   DQ375985 ABD37876   EC051737   EC052221   EC052769   EC056070   EC064994   EC216512   EC246531   EC248327   EC251638   EC267780   EL870401   EV596117   EV599430   FE863080
UniProtKB/Swiss-Prot	Q9V3A4
UniProtKB/TrEMBL	Q2EJA5 Q2EJB1 Q2EJB6 Q2EJB7 Q2EJC0 Q2EJD1 Q2EJD4 Q2EJD6 Q2EJD8 Q2EJE1 Q2EJE2 Q2EJE6 Q2EJE9 Q2EJF2 Q2EJF3 Q2EJF5 Q2EJG6 Q2EJH2 Q2EJI9 Q2EJJ6 Q2EJJ7 Q2EJK8 Q2EJK9 Q2EJL0 Q2EJL5 Q2EJL9 Q2EJM0 Q2EJM1 Q2EJM5 Q2EJM6 Q2EJN0 Q2EJN2 Q2EJP0 Q2EJP2 Q2EJP5 Q2EJQ0 Q2EJQ2 Q2EJQ4 Q2EJQ6 Q2EJQ7 Q2EJQ8 Q2EJQ9 Q2EJR0 Q2EJR1 Q2EJR3 Q2EJR5 Q2EJR6 Q2EJR7 Q2EJS1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0002022    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0002022 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed within 00-18 hour embryonic stages, during late larval stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0002022 expression level Developmental Stage   Expression Level embryo 00-02hr    3974 embryo 02-04hr    5851 embryo 04-06hr    5217 embryo 06-08hr    4227 embryo 08-10hr    5300 embryo 10-12hr    6848 embryo 12-14hr    5710 embryo 14-16hr    5640 embryo 16-18hr    4386 embryo 18-20hr    2613 embryo 20-22hr    2462 embryo 22-24hr    2268 larva L1    2084 larva L2    3906 larva L3 12hr old    3404 larva L3 puffstage 1-2    3855 larva L3 puffstage 3-6    4240 larva L3 puffstage 7-9    3770 white prepupae new    3804 white prepupae 12hr    2617 white prepupae 24hr    2995 pupae 2d postWPP    2770 pupae 3d postWPP    1813 pupae 4d postWPP    1602 adult male 01day    2712 adult male 05day    3371 adult male 30day    3266 adult female 01day    2462 adult female 05day    3117 adult female 30day    3162 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3974) embryo 02-04hr  (5851) embryo 04-06hr  (5217) embryo 06-08hr  (4227) embryo 08-10hr  (5300) embryo 10-12hr  (6848) embryo 12-14hr  (5710) embryo 14-16hr  (5640) embryo 16-18hr  (4386) embryo 18-20hr  (2613) embryo 20-22hr  (2462) embryo 22-24hr  (2268) larva L1  (2084) larva L2  (3906) larva L3 12hr old  (3404) larva L3 puffstage 1-2  (3855) larva L3 puffstage 3-6  (4240) larva L3 puffstage 7-9  (3770) white prepupae new  (3804) white prepupae 12hr  (2617) white prepupae 24hr  (2995) pupae 2d postWPP  (2770) pupae 3d postWPP  (1813) pupae 4d postWPP  (1602) adult male 01day  (2712) adult male 05day  (3371) adult male 30day  (3266) adult female 01day  (2462) adult female 05day  (3117) adult female 30day  (3162) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3974) embryo 02-04hr  (5851) embryo 04-06hr  (5217) embryo 06-08hr  (4227) embryo 08-10hr  (5300) embryo 10-12hr  (6848) embryo 12-14hr  (5710) embryo 14-16hr  (5640) embryo 16-18hr  (4386) embryo 18-20hr  (2613) embryo 20-22hr  (2462) embryo 22-24hr  (2268) larva L1  (2084) larva L2  (3906) larva L3 12hr old  (3404) larva L3 puffstage 1-2  (3855) larva L3 puffstage 3-6  (4240) larva L3 puffstage 7-9  (3770) white prepupae new  (3804) white prepupae 12hr  (2617) white prepupae 24hr  (2995) pupae 2d postWPP  (2770) pupae 3d postWPP  (1813) pupae 4d postWPP  (1602) adult male 01day  (2712) adult male 05day  (3371) adult male 30day  (3266) adult female 01day  (2462) adult female 05day  (3117) adult female 30day  (3162) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3974 embryo 02-04hr    5851 embryo 04-06hr    5217 embryo 06-08hr    4227 embryo 08-10hr    5300 embryo 10-12hr    6848 embryo 12-14hr    5710 embryo 14-16hr    5640 embryo 16-18hr    4386 embryo 18-20hr    2613 embryo 20-22hr    2462 embryo 22-24hr    2268 larva L1    2084 larva L2    3906 larva L3 12hr old    3404 larva L3 puffstage 1-2    3855 larva L3 puffstage 3-6    4240 larva L3 puffstage 7-9    3770 white prepupae new    3804 white prepupae 12hr    2617 white prepupae 24hr    2995 pupae 2d postWPP    2770 pupae 3d postWPP    1813 pupae 4d postWPP    1602 adult male 01day    2712 adult male 05day    3371 adult male 30day    3266 adult female 01day    2462 adult female 05day    3117 adult female 30day    3162 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3974 embryo 02-04hr    5851 embryo 04-06hr    5217 embryo 06-08hr    4227 embryo 08-10hr    5300 embryo 10-12hr    6848 embryo 12-14hr    5710 embryo 14-16hr    5640 embryo 16-18hr    4386 embryo 18-20hr    2613 embryo 20-22hr    2462 embryo 22-24hr    2268 larva L1    2084 larva L2    3906 larva L3 12hr old    3404 larva L3 puffstage 1-2    3855 larva L3 puffstage 3-6    4240 larva L3 puffstage 7-9    3770 white prepupae new    3804 white prepupae 12hr    2617 white prepupae 24hr    2995 pupae 2d postWPP    2770 pupae 3d postWPP    1813 pupae 4d postWPP    1602 adult male 01day    2712 adult male 05day    3371 adult male 30day    3266 adult female 01day    2462 adult female 05day    3117 adult female 30day    3162 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0002022 expression level Developmental Stage   Expression Level embryo 00-02hr    3974 embryo 02-04hr    5851 embryo 04-06hr    5217 embryo 06-08hr    4227 embryo 08-10hr    5300 embryo 10-12hr    6848 embryo 12-14hr    5710 embryo 14-16hr    5640 embryo 16-18hr    4386 embryo 18-20hr    2613 embryo 20-22hr    2462 embryo 22-24hr    2268 larva L1    2084 larva L2    3906 larva L3 12hr old    3404 larva L3 puffstage 1-2    3855 larva L3 puffstage 3-6    4240 larva L3 puffstage 7-9    3770 white prepupae new    3804 white prepupae 12hr    2617 white prepupae 24hr    2995 pupae 2d postWPP    2770 pupae 3d postWPP    1813 pupae 4d postWPP    1602 adult male 01day    2712 adult male 05day    3371 adult male 30day    3266 adult female 01day    2462 adult female 05day    3117 adult female 30day    3162 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3974) embryo 02-04hr  (5851) embryo 04-06hr  (5217) embryo 06-08hr  (4227) embryo 08-10hr  (5300) embryo 10-12hr  (6848) embryo 12-14hr  (5710) embryo 14-16hr  (5640) embryo 16-18hr  (4386) embryo 18-20hr  (2613) embryo 20-22hr  (2462) embryo 22-24hr  (2268) larva L1  (2084) larva L2  (3906) larva L3 12hr old  (3404) larva L3 puffstage 1-2  (3855) larva L3 puffstage 3-6  (4240) larva L3 puffstage 7-9  (3770) white prepupae new  (3804) white prepupae 12hr  (2617) white prepupae 24hr  (2995) pupae 2d postWPP  (2770) pupae 3d postWPP  (1813) pupae 4d postWPP  (1602) adult male 01day  (2712) adult male 05day  (3371) adult male 30day  (3266) adult female 01day  (2462) adult female 05day  (3117) adult female 30day  (3162) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3974) embryo 02-04hr  (5851) embryo 04-06hr  (5217) embryo 06-08hr  (4227) embryo 08-10hr  (5300) embryo 10-12hr  (6848) embryo 12-14hr  (5710) embryo 14-16hr  (5640) embryo 16-18hr  (4386) embryo 18-20hr  (2613) embryo 20-22hr  2462 embryo 22-24hr  2268 larva L1  2084 larva L2  (3906) larva L3 12hr old  (3404) larva L3 puffstage 1-2  (3855) larva L3 puffstage 3-6  (4240) larva L3 puffstage 7-9  (3770) white prepupae new  (3804) white prepupae 12hr  (2617) white prepupae 24hr  (2995) pupae 2d postWPP  (2770) pupae 3d postWPP  1813 pupae 4d postWPP  1602 adult male 01day  (2712) adult male 05day  (3371) adult male 30day  (3266) adult female 01day  2462 adult female 05day  (3117) adult female 30day  (3162) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3974 embryo 02-04hr    5851 embryo 04-06hr    5217 embryo 06-08hr    4227 embryo 08-10hr    5300 embryo 10-12hr    6848 embryo 12-14hr    5710 embryo 14-16hr    5640 embryo 16-18hr    4386 embryo 18-20hr    2613 embryo 20-22hr    2462 embryo 22-24hr    2268 larva L1    2084 larva L2    3906 larva L3 12hr old    3404 larva L3 puffstage 1-2    3855 larva L3 puffstage 3-6    4240 larva L3 puffstage 7-9    3770 white prepupae new    3804 white prepupae 12hr    2617 white prepupae 24hr    2995 pupae 2d postWPP    2770 pupae 3d postWPP    1813 pupae 4d postWPP    1602 adult male 01day    2712 adult male 05day    3371 adult male 30day    3266 adult female 01day    2462 adult female 05day    3117 adult female 30day    3162 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3974 embryo 02-04hr    5851 embryo 04-06hr    5217 embryo 06-08hr    4227 embryo 08-10hr    5300 embryo 10-12hr    6848 embryo 12-14hr    5710 embryo 14-16hr    5640 embryo 16-18hr    4386 embryo 18-20hr    2613 embryo 20-22hr    2462 embryo 22-24hr    2268 larva L1    2084 larva L2    3906 larva L3 12hr old    3404 larva L3 puffstage 1-2    3855 larva L3 puffstage 3-6    4240 larva L3 puffstage 7-9    3770 white prepupae new    3804 white prepupae 12hr    2617 white prepupae 24hr    2995 pupae 2d postWPP    2770 pupae 3d postWPP    1813 pupae 4d postWPP    1602 adult male 01day    2712 adult male 05day    3371 adult male 30day    3266 adult female 01day    2462 adult female 05day    3117 adult female 30day    3162 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0002022    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0002022 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult midgut, larval/adult Malpighian tubules, larval fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval midgut, larval/adult hindgut, adult heart, adult fat body, adult ovary, adult testis, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0002022 expression level Tissue   Expression Level Larval Central Nervous System    306.875 Larval Midgut    386.8 Larval Hindgut    406.5 Larval Malpighian Tubules    805.6 Larval Fat Body    1097.9 Larval Salivary Gland    2077.6 Larval Trachea    629.575 Larval Carcass    497.325 Adult Head    385.6 Adult Eye    424 Adult Brain    177.5 Adult Thoracic-Abdominal Ganglion    218.2 Adult Crop    418.1 Adult Midgut    587.4 Adult Hindgut    454.3 Adult Malpighian Tubules    677.3 Adult Fat Body    429.6 Adult Salivary Gland    1424 Adult Heart    434.225 Adult VirginFemale Spermatheca    662.9 Adult InseminatedFemale Spermatheca    736.9 Adult Ovary    288.9 Adult Testis    293.5 Adult Male Accessory Gland    1576.9 Adult Carcass    400.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    306.875 Larval Midgut    386.8 Larval Hindgut    406.5 Larval Malpighian Tubules  (805.6) Larval Fat Body  (1097.9) Larval Salivary Gland  (2077.6) Larval Trachea  (629.575) Larval Carcass    497.325 Adult Head    385.6 Adult Eye    424 Adult Brain    177.5 Adult Thoracic-Abdominal Ganglion    218.2 Adult Crop    418.1 Adult Midgut  (587.4) Adult Hindgut    454.3 Adult Malpighian Tubules  (677.3) Adult Fat Body    429.6 Adult Salivary Gland  (1424) Adult Heart    434.225 Adult VirginFemale Spermatheca  (662.9) Adult InseminatedFemale Spermatheca  (736.9) Adult Ovary    288.9 Adult Testis    293.5 Adult Male Accessory Gland  (1576.9) Adult Carcass    400.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    306.875 Larval Midgut    386.8 Larval Hindgut    406.5 Larval Malpighian Tubules    805.6 Larval Fat Body  (1097.9) Larval Salivary Gland  (2077.6) Larval Trachea    629.575 Larval Carcass    497.325 Adult Head    385.6 Adult Eye    424 Adult Brain    177.5 Adult Thoracic-Abdominal Ganglion    218.2 Adult Crop    418.1 Adult Midgut    587.4 Adult Hindgut    454.3 Adult Malpighian Tubules    677.3 Adult Fat Body    429.6 Adult Salivary Gland  (1424) Adult Heart    434.225 Adult VirginFemale Spermatheca    662.9 Adult InseminatedFemale Spermatheca    736.9 Adult Ovary    288.9 Adult Testis    293.5 Adult Male Accessory Gland  (1576.9) Adult Carcass    400.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    306.875 Larval Midgut    386.8 Larval Hindgut    406.5 Larval Malpighian Tubules    805.6 Larval Fat Body    1097.9 Larval Salivary Gland    2077.6 Larval Trachea    629.575 Larval Carcass    497.325 Adult Head    385.6 Adult Eye    424 Adult Brain    177.5 Adult Thoracic-Abdominal Ganglion    218.2 Adult Crop    418.1 Adult Midgut    587.4 Adult Hindgut    454.3 Adult Malpighian Tubules    677.3 Adult Fat Body    429.6 Adult Salivary Gland    1424 Adult Heart    434.225 Adult VirginFemale Spermatheca    662.9 Adult InseminatedFemale Spermatheca    736.9 Adult Ovary    288.9 Adult Testis    293.5 Adult Male Accessory Gland    1576.9 Adult Carcass    400.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0002022 expression level Tissue   Expression Level Larval Central Nervous System    306.875 Larval Midgut    386.8 Larval Hindgut    406.5 Larval Malpighian Tubules    805.6 Larval Fat Body    1097.9 Larval Salivary Gland    2077.6 Larval Trachea    629.575 Larval Carcass    497.325 Adult Head    385.6 Adult Eye    424 Adult Brain    177.5 Adult Thoracic-Abdominal Ganglion    218.2 Adult Crop    418.1 Adult Midgut    587.4 Adult Hindgut    454.3 Adult Malpighian Tubules    677.3 Adult Fat Body    429.6 Adult Salivary Gland    1424 Adult Heart    434.225 Adult VirginFemale Spermatheca    662.9 Adult InseminatedFemale Spermatheca    736.9 Adult Ovary    288.9 Adult Testis    293.5 Adult Male Accessory Gland    1576.9 Adult Carcass    400.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    306.875 Larval Midgut    386.8 Larval Hindgut    406.5 Larval Malpighian Tubules  805.6 Larval Fat Body  (1097.9) Larval Salivary Gland  (2077.6) Larval Trachea  629.575 Larval Carcass    497.325 Adult Head    385.6 Adult Eye    424 Adult Brain    177.5 Adult Thoracic-Abdominal Ganglion    218.2 Adult Crop    418.1 Adult Midgut  587.4 Adult Hindgut    454.3 Adult Malpighian Tubules  677.3 Adult Fat Body    429.6 Adult Salivary Gland  (1424) Adult Heart    434.225 Adult VirginFemale Spermatheca  662.9 Adult InseminatedFemale Spermatheca  736.9 Adult Ovary    288.9 Adult Testis    293.5 Adult Male Accessory Gland  (1576.9) Adult Carcass    400.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    306.875 Larval Midgut    386.8 Larval Hindgut    406.5 Larval Malpighian Tubules    805.6 Larval Fat Body  1097.9 Larval Salivary Gland  (2077.6) Larval Trachea    629.575 Larval Carcass    497.325 Adult Head    385.6 Adult Eye    424 Adult Brain    177.5 Adult Thoracic-Abdominal Ganglion    218.2 Adult Crop    418.1 Adult Midgut    587.4 Adult Hindgut    454.3 Adult Malpighian Tubules    677.3 Adult Fat Body    429.6 Adult Salivary Gland  1424 Adult Heart    434.225 Adult VirginFemale Spermatheca    662.9 Adult InseminatedFemale Spermatheca    736.9 Adult Ovary    288.9 Adult Testis    293.5 Adult Male Accessory Gland  1576.9 Adult Carcass    400.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    306.875 Larval Midgut    386.8 Larval Hindgut    406.5 Larval Malpighian Tubules    805.6 Larval Fat Body    1097.9 Larval Salivary Gland    2077.6 Larval Trachea    629.575 Larval Carcass    497.325 Adult Head    385.6 Adult Eye    424 Adult Brain    177.5 Adult Thoracic-Abdominal Ganglion    218.2 Adult Crop    418.1 Adult Midgut    587.4 Adult Hindgut    454.3 Adult Malpighian Tubules    677.3 Adult Fat Body    429.6 Adult Salivary Gland    1424 Adult Heart    434.225 Adult VirginFemale Spermatheca    662.9 Adult InseminatedFemale Spermatheca    736.9 Adult Ovary    288.9 Adult Testis    293.5 Adult Male Accessory Gland    1576.9 Adult Carcass    400.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    385.6   NA  Eye    424   NA  Brain    177.5   306.875  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    218.2   NA  Crop    418.1   386.8  Midgut    587.4   406.5  Hindgut    454.3   805.6  Malpighian Tubules    677.3   1097.9  Fat Body    429.6   2077.6  Salivary Gland    1424   NA  Heart    434.225   629.575  Trachea    NA   NA  VirginFemale Spermatheca    662.9   NA  InseminatedFemale Spermatheca    736.9   NA  Ovary    288.9   NA  Testis    293.5   NA  Male Accessory Gland    1576.9   497.325  Carcass    400.6 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_03
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002022 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10449-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Catsup Stages(s) 1-3 Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4Act5C.PU CatsupGD1635 lethal, with Scer\GAL4GMR.PF, Scer\GAL4ey.PH CatsupGD1635 lethal, with Scer\GAL4pnr-MD237 CatsupGD1635 lethal | larval stage Catsup9 lethal | larval stage | recessive Catsup1 lethal | male, with Scer\GAL4Bx-MS1096 CatsupGD1635 lethal | pupal stage | recessive Catsup11 lethal | recessive Catsup1 Catsup2 Catsup3 Catsup4 Catsup5 Catsup6 Catsup7 Catsup8 Catsup9 Catsup10 Catsup12 Catsup13 Catsup14 Catsup15 Catsup16 Catsup17 Catsup18 Catsup19 Catsup20 Catsup21 Catsup22 Catsup23 Catsup24 Catsup25 Catsupk05402 Catsupk05424 Catsupk05438 lethal | recessive | cold sensitive Catsupcs1 Catsupcs2 lethal | recessive | heat sensitive Catsupts1 semi-lethal | female, with Scer\GAL4Bx-MS1096 CatsupGD1635 semi-lethal | recessive Catsup11 Catsup19 viable Catsupfs1 Sterility Allele female fertile Catsupts1 female sterile Catsupcs1 Catsupcs2 Catsupfs1 female sterile | recessive Catsup11 Catsup14 Catsup17 Catsup19 Catsupcs1 Catsupcs2 Catsupfs1 Other Phenotypes Allele melanotic mass phenotype Catsup9 Catsup20 Catsupfs1 melanotic mass phenotype | dominant Catsup3 Catsup5 Catsup6 Catsup8 Catsup11 Catsup13 Catsup22 Catsupcs1 Catsupcs2 Catsupfs1 wild-type Catsup+t6.9 Catsup+t9.1 Phenotype manifest in Allele adult cuticle Catsup11 adult cuticle & abdomen Catsup11 adult cuticle & adult abdomen Catsup11 crystal cell Catsup1 Catsupk05424 dorsal appendage Catsupfs1 dorsal appendage | germline clone Catsup1 egg | germline clone Catsup1 embryonic/larval salivary gland | embryonic stage Catsup11 epidermis | pharate adult stage Catsup11 eye Catsup11 hemolymph Catsup11 macrochaeta Catsup11 macrochaeta & adult abdomen Catsup11 melanotic mass Catsup11 Catsup13 Catsup22 Catsup3 Catsup5 Catsup6 Catsup8 Catsupcs1 Catsupcs2 Catsupfs1 pupal cuticle Catsup11 tergite Catsup11 wing, with Scer\GAL4Bx-MS1096 CatsupGD1635
Classical Alleles ( 56 )
For All Classical Alleles Show
Allele of Catsup Class Mutagen Stocks Known lesion Catsup1 ethyl methanesulfonate 2 -- Catsupk05424 P-element activity 2 -- Catsupcs1 ethyl methanesulfonate gamma ray 1 -- Catsupcs2 ethyl methanesulfonate 1 -- Catsupd07915 P-element activity 1 -- CatsupNP7008 1 -- Catsup12 amorphic allele - genetic evidence ethyl methanesulfonate formaldehyde 0 Yes Catsup10 spontaneous 0 -- Catsup11 hypomorphic allele - genetic evidence ethyl methanesulfonate formaldehyde 0 -- Catsup13 ethyl methanesulfonate formaldehyde 0 -- Catsup14 ethyl methanesulfonate formaldehyde 0 -- Catsup15 ethyl methanesulfonate 0 -- Catsup16 ethyl methanesulfonate 0 -- Catsup17 ethyl methanesulfonate 0 -- Catsup18 ethyl methanesulfonate 0 -- Catsup19 ethyl methanesulfonate 0 -- Catsup20 ethyl methanesulfonate gamma ray 0 -- Catsup21 ethyl methanesulfonate gamma ray 0 -- Catsup22 ethyl methanesulfonate 0 -- Catsup23 ethyl methanesulfonate gamma ray 0 -- Catsup24 ethyl methanesulfonate gamma ray 0 -- Catsup25 ethyl methanesulfonate gamma ray 0 -- Catsup26 Delta2-3 0 Yes Catsup27 Delta2-3 0 Yes Catsup28 Delta2-3 0 Yes Catsup29 Delta2-3 0 Yes Catsup2 ethyl methanesulfonate 0 -- Catsup30 Delta2-3 0 Yes Catsup31 Delta2-3 0 Yes Catsup32 Delta2-3 0 Yes Catsup33 Delta2-3 0 Yes Catsup34 Delta2-3 0 Yes Catsup35 Delta2-3 0 Yes Catsup36 Delta2-3 0 Yes Catsup37 Delta2-3 0 Yes Catsup38 Delta2-3 0 Yes Catsup39 Delta2-3 0 Yes Catsup3 ethyl methanesulfonate 0 -- Catsup40 Delta2-3 0 Yes Catsup41 Delta2-3 0 Yes Catsup42 Delta2-3 0 Yes Catsup43 Delta2-3 0 Yes Catsup44 Delta2-3 0 Yes Catsup45 Delta2-3 0 Yes Catsup46 Delta2-3 0 Yes Catsup4 ethyl methanesulfonate 0 -- Catsup5 ethyl methanesulfonate 0 -- Catsup6 ethyl methanesulfonate 0 -- Catsup7 ethyl methanesulfonate 0 -- Catsup8 ethyl methanesulfonate 0 -- Catsup9 ethyl methanesulfonate 0 -- Catsupfs1 ethyl methanesulfonate gamma ray 0 -- Catsupk05402 P-element activity 0 Yes Catsupk05438 P-element activity 0 -- Catsupts1 ethyl methanesulfonate 0 -- Catsupunspecified 0 --
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Catsup Class Mutagen Stocks Known lesion CatsupGD1635 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes CatsupKK103630 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Catsup+t6.9 in vitro construct - genomic fragment 0 Yes Catsup+t9.1 in vitro construct - genomic fragment 0 Yes CatsupB3 in vitro construct - genomic fragment 0 Yes CatsupB4 in vitro construct - genomic fragment 0 Yes CatsupB5 in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)BSC257 (Christensen and Cook, 2007.3.22) Df(2L)BSC341 (Christensen and Cook, 2007.10.29) Df(2L)Catsup44 (Stathakis et al., 1999) Df(2L)Catsup45 (Stathakis et al., 1999) Df(2L)Catsup46 (Stathakis et al., 1999) Df(2L)E71 (Wright et al., 1981) Df(2L)Exel6042 (Ryder, 2004.4.26) Df(2L)Exel8039 (Ryder, 2004.4.26) Df(2L)hk18 (Pentz et al., 1986, Wright, 1996) Df(2L)hk-UC1 (BDGP Project Members, 1994-1999, Stathakis et al., 1995, Wright, 1996) Df(2L)hk-UC2 (Stathakis et al., 1995, Wright, 1996) Df(2L)OD15 (Stathakis et al., 1999, Pentz et al., 1986, BDGP Project Members, 1994-1999, Stathakis et al., 1995, Wright, 1996, Thor and Thomas, 1997) Df(2L)TW50 (Spradling et al., 1999, Wright et al., 1976, BDGP Project Members, 1994-1999) Df(2L)TW130 (Stathakis et al., 1999, Wright et al., 1976, Wright et al., 1981, Stathakis et al., 1995, Wright, 1996) Df(2L)VA18 (Gilbert et al., 1984, Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) Df(2L)VA21 (Stathakis et al., 1995, Wright, 1996) Df(2L)VA23 (Stathakis et al., 1995)
Not disrupted in	Df(2L)E55 (Stathakis et al., 1995) Df(2L)M36F-S5 (BDGP Project Members, 1994-1999) Df(2L)NST (Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) Df(2L)Sd37 (Stathakis et al., 1995, Wright, 1996) Df(2L)Sd57 (Stathakis et al., 1995, Wright, 1996) Df(2L)Sd77 (Stathakis et al., 1995, Wright, 1996) Df(2L)TE37C-1 (Wright et al., 1981, Gilbert et al., 1984, Wright, 1996) Df(2L)TE37C-7 (Stathakis et al., 1995, Wright, 1996) Df(2L)TW3 (BDGP Project Members, 1994-1999, Thor and Thomas, 1997) Df(2L)TW65 (BDGP Project Members, 1994-1999) Df(2L)TW137 (BDGP Project Members, 1994-1999, Stathakis et al., 1995) Df(2L)TW203 (Pentz et al., 1986, BDGP Project Members, 1994-1999, Stathakis et al., 1995, Wright, 1996) Df(2L)VA12 (Wright et al., 1981, Gilbert et al., 1984, Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) Df(2L)VA13 (Wright et al., 1981, Gilbert et al., 1984, Wright, 1996) Df(2L)VA17 (Wright et al., 1981, Gilbert et al., 1984, Pentz et al., 1986, BDGP Project Members, 1994-1999, Stathakis et al., 1995, Wright, 1996) Df(2L)VA19 (Stathakis et al., 1995, Wright, 1996)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD1635} NA P{KK103630} NA characterization construct P{pB1} NA P{pB2} NA P{pB3} NA P{pB4} NA P{pB5} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}Catsupk05402 No P{lacW}Catsupk05424 No P{lacW}Catsupk05438 No P{lacW}l(2)SH1139SH1139 No insertion of mobile activating element P{XP}Catsupd07915 NA insertion of enhancer trap binary system P{GawB}CatsupNP7008 No miscellaneous insertions P{?lacW}Catsup28 NA P{?lacW}Catsup29 NA P{?lacW}Catsup30 NA P{?lacW}Catsup31 NA P{?lacW}Catsup32 NA P{?lacW}Catsup33 NA P{?lacW}Catsup34 NA P{?lacW}Catsup35 NA P{?lacW}Catsup36 NA P{?lacW}Catsup37 NA P{?lacW}Catsup38 NA P{?lacW}Catsup39 NA P{?lacW}Catsup40 NA P{?lacW}Catsup41 NA P{?lacW}Catsup42 NA P{?lacW}Catsup43 NA
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function
CV term Evidence References
enzyme regulator activity inferred from mutant phenotype (Stathakis et al., 1999)
Biological Process
CV term Evidence References
ovarian nurse cell to oocyte transport inferred from mutant phenotype (Schupbach and Wieschaus, 1991) regulation of catecholamine metabolic process inferred from mutant phenotype (Stathakis et al., 1999) regulation of epithelial cell migration, open tracheal system inferred from mutant phenotype (Hsouna et al., 2007)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
metal ion transmembrane transporter activity inferred from electronic annotation with InterPro:IPR003689 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
metal ion transport inferred from electronic annotation with InterPro:IPR003689 (FlyBase Curators et al., 2004-) transmembrane transport inferred from electronic annotation with InterPro:IPR003689 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
integral to plasma membrane non-traceable author statement (Swiss-Prot Project Members, 2000.10.1) membrane inferred from electronic annotation with InterPro:IPR003689 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Catsup allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 71703 DroID - A comprehensive database of gene and protein interactions. • FBgn0002022 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 48805
Orthologs
Genome-wide drosophilid orthologs	Dana\GF14692 Dere\GG21151 Dgri\GH10891 Dmoj\GI13064 Dper\GL18911 Dpse\GA10324 Dsec\GM17316 Dsim\Catsup Dvir\GJ11603 Dwil\GK24165 Dyak\GE13224
Curated drosophilid orthologs	Dpse\GA10324   Dsim\Catsup (Carbone et al., 2006.1.25)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL001968-PA Aedes aegypti (mosquito) AGAP008034-PA Anopheles gambiae (mosquito) XP_395560.2 Apis mellifera (honey bee) XP_001949272.1 Acyrthosiphon pisum (pea aphid) At1g68100.1 Arabidopsis thaliana (wall cress) 124484 Branchiostoma floridae (lancelet) XP_001894219.1 Brugia malayi (roundworm nematode) BGIBMGA002971-PA Bombyx mori (silk worm) ENSBTAP00000050674 Bos taurus (bovine) CN09907 Caenorhabditis brenneri (small nematode) CBP26486 Caenorhabditis briggsae (nematode) CE38718 Caenorhabditis elegans (worm) ENSCAFP00000001312 Canis familiaris (dog) CAGL0I05280g Candida glabrata (haploid yeast) ENSCINP00000017027 Ciona intestinalis (sea squirt) JA10634 Caenorhabditis japonica (nematode) CMP282C Cyanidioschyzon merolae (red alga) cn03120 Cryptococcus neoformans (yeast-like fungus) CPIJ008087 Culex pipens (mosquito) ENSCPOP00000017364 Cavia porcellus (guinea pig) RP22705 Caenorhabditis remanei (nematode) 24325 Capitella spl (polychaete worm) 220710 Daphnia pulex (daphnia) ENSDARP00000052863 Danio rerio (zebra fish) ENSECAP00000003850 Equus caballus (horse) 185976 Hypsipyla robusta (cedar shoot borer) ENSP00000363809 Homo sapiens (human) ENSP00000372560 Homo sapiens (human) ENSP00000372701 Homo sapiens (human) ISCW017090-PA Ixodes scapularis (deer tick) KLLA0F17886g Kluyveromyces lactis (yeast) 94834 Lottia gigantea (owl limpet) ENSMODP00000017798 Monodelphis domestica (gray opossum) ENSMMUP00000005149 Macaca mulatta (rhesus monkey) ENSMUSP00000025186 Mus musculus (house mouse) 241132 Nematostella vectensis (starlet anemone) XP_001605825.1 Nasonia vitripennis (wasp) ENSORLP00000007374 Oryzias latipes (japanese killifish) LOC_Os08g36420.1 Oryza sativa (asian rice) PHUM001836-PA Pediculus humanus (human body louse) PP06118 Pristionchus pacificus (nematode) 98954 Physcomitrella patens (moss) ENSPPYP00000019325 Pongo pygmaeus (orangutan) 82538 Phytophthora ramorum (sudden oak death pathogen) 720768 Populus trichocarpa (black cottonwood) ENSPTRP00000030803 Pan troglodytes (chimpanzee) ENSRNOP00000000541 Rattus norvegicus (norway rat) 5058832 Sorghum bicolor (sorghum) Smp_139720 Schistosoma mansoni (trematode parasite) SPAP8A3.03 Schizosaccharomyces pombe (fission yeast) XP_787748.1 Strongylocentrotus purpuratus (purple sea urchin) 20426 Trichoplax adhaerens (metazoa) XP_974198.1 Tribolium castaneum (red flour beetle) ENSTNIP00000021341 Tetraodon nigroviridis (green spotted pufferfish) 260850 Thalassiosira pseudonana (marine diatom) ENSTRUP00000007706 Takifugu rubripes (pufferfish Takifugu) 220.m00041 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000043930 Xenopus tropicalis (frog) YALI0F04312g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14914 NV11665 LH22473 ISCW017090 FBgn0230918 FBgn0226127 FBgn0198860 FBgn0084332 FBgn0172226 JGI_V11_220710 FBgn0070382 FBgn0156512 FBgn0135821 FBgn0118372 FBgn0113334 FBgn0091719 CPIJ008087 BGIBMGA002971 ACYPI004908 GB12946 AGAP008034 AAEL001968 PHUM463380 GLEAN_13479
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	3987 Catsup1 rdo1 hk1 pr1/CyO 10572 y1 w67c23; P{lacW}Catsupk05424/CyO
Harvard	- P{XP}Catsupd07915
Kyoto	107543 Catsup1 rdo1 hk1 pr1/CyO 105327 y* w*; P{GawB}CatsupNP7008 / CyO, P{UAS-lacZ.UW14}UW14 101392 CyO, Cy1 dplv1 pr1 cn2 / Catsupcs1 pr1 101397 CyO, Cy1 dplv1 pr1 cn2 / Catsupcs2 cn1 bw1 114343 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{lacW}Catsupk05424 P{neoFRT}40A/CyO y+
VDRC	v100095 P{KK103630}VIE-260B v7183 w1118; P{GD1635}v7183/TM3
Genomic Clones ( 2 )
	BACR04C20 BACR17A06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 56 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD23513
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT03420 GH07460 GH08046 GH08058 LD02041 LD16795 LD22964 LD28882 LD29989 LD30077 LD35391 LP15104 RE12223 RE17421 RE18242 RE21906 RE25524 RE32008 RE37285 RE42292 RE45948 RE46723 RE46874 RE47155 RE47156 RE47644 RE54948 RE61602 SD12707 SD15361 SD22426
Other clones	63292 104112 214535.30 557925 Dmel_neb_013144_0904_0754 Dmel_neb_015086_0605_2389 EC23432 EC29732 EC051737 EC052221 EC052769 EC056070 EK045243 EK188910 EK227264 EK243347 EK300760 EN12650 EN16004 EP09324 ESG0113a.B21_G01 FGC006C05 IP02496 RM07167
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0002022 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 48805
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Catsup CG10449 (Bayraktaroglu, 2000.8.7) Source for merge of: Catsup l(2)k05424 (FlyBase, 1996-)
Additional comments	Source for merge of Catsup l(2)k05424 was a shared cDNA (date:030206). (FlyBase, 1996-)
Other Comments
	Catsup is a pleiotropic quantitative trait gene affecting lifespan and locomotor behaviour. (Carbone et al., 2006) Catsup mutants have significantly elevated ple enzyme activity that may arise from a post-translational modification of the ple enzyme. The hyperactivation of ple enzyme results in abnormally high levels of catecholamines, which can account for the lethality, visible phenotypes and female sterility observed in the mutants. (Stathakis et al., 1999) Mutations in Catsup exhibit morphological defects of the cuticle. Catsup is essential for catecholamine metabolism in cuticle formation. Null and weak alleles of Catsup are semidominant larval lethal that produce variable and pleiotropic phenotypes including promiscuous melanisation of the salivary and lymph glands, extensive regions of incomplete epicuticle development and formation of large melanotic tumours. (Stathakis et al., 1995) Located between coordinates -74.5 and -72.4. (Stathakis et al., 1995) Mutations at the l(2)37Bc locus cause defects in midoogenesis. (Schupbach and Wieschaus, 1991)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080192 RefSeq (Proteins) • NP_524931 DDBJ / EMBL / GenBank • AA817564 AAF37226 AAF53744 AAL13757 ABD37706 ABD37707 ABD37708 ABD37709 ABD37710 ABD37711 ABD37712 ABD37713 ABD37714 ABD37715 ABD37716 ABD37717 ABD37718 ABD37719 ABD37720 ABD37721 ABD37722 ABD37723 ABD37724 ABD37725 ABD37726 ABD37727 ABD37728 ABD37729 ABD37730 ABD37731 ABD37732 ABD37733 ABD37734 ABD37735 ABD37736 ABD37737 ABD37738 ABD37739 ABD37740 ABD37741 ABD37742 ABD37743 ABD37744 ABD37745 ABD37746 ABD37747 ABD37748 ABD37749 ABD37750 ABD37751 ABD37752 ABD37753 ABD37754 ABD37755 ABD37756 ABD37757 ABD37758 ABD37759 ABD37760 ABD37761 ABD37762 ABD37763 ABD37764 ABD37765 ABD37766 ABD37767 ABD37768 ABD37769 ABD37770 ABD37771 ABD37772 ABD37773 ABD37774 ABD37775 ABD37776 ABD37777 ABD37778 ABD37779 ABD37780 ABD37781 ABD37782 ABD37783 ABD37784 ABD37785 ABD37786 ABD37787 ABD37788 ABD37789 ABD37790 ABD37791 ABD37792 ABD37793 ABD37794 ABD37795 ABD37796 ABD37797 ABD37798 ABD37799 ABD37800 ABD37801 ABD37802 ABD37803 ABD37804 ABD37805 ABD37806 ABD37807 ABD37808 ABD37809 ABD37810 ABD37811 ABD37812 ABD37813 ABD37814 ABD37815 ABD37816 ABD37817 ABD37818 ABD37819 ABD37820 ABD37821 ABD37822 ABD37823 ABD37824 ABD37825 ABD37826 ABD37827 ABD37828 ABD37829 ABD37830 ABD37831 ABD37832 ABD37833 ABD37834 ABD37835 ABD37836 ABD37837 ABD37838 ABD37839 ABD37840 ABD37841 ABD37842 ABD37843 ABD37844 ABD37845 ABD37846 ABD37847 ABD37848 ABD37849 ABD37850 ABD37851 ABD37852 ABD37853 ABD37854 ABD37855 ABD37856 ABD37857 ABD37858 ABD37859 ABD37860 ABD37861 ABD37862 ABD37863 ABD37864 ABD37865 ABD37866 ABD37867 ABD37868 ABD37869 ABD37870 ABD37871 ABD37872 ABD37873 ABD37874 ABD37875 ABD37876 AF216584 AI455330 AQ025760 AY058528 CZ475990 DQ375815 DQ375816 DQ375817 DQ375818 DQ375819 DQ375820 DQ375821 DQ375822 DQ375823 DQ375824 DQ375825 DQ375826 DQ375827 DQ375828 DQ375829 DQ375830 DQ375831 DQ375832 DQ375833 DQ375834 DQ375835 DQ375836 DQ375837 DQ375838 DQ375839 DQ375840 DQ375841 DQ375842 DQ375843 DQ375844 DQ375845 DQ375846 DQ375847 DQ375848 DQ375849 DQ375850 DQ375851 DQ375852 DQ375853 DQ375854 DQ375855 DQ375856 DQ375857 DQ375858 DQ375859 DQ375860 DQ375861 DQ375862 DQ375863 DQ375864 DQ375865 DQ375866 DQ375867 DQ375868 DQ375869 DQ375870 DQ375871 DQ375872 DQ375873 DQ375874 DQ375875 DQ375876 DQ375877 DQ375878 DQ375879 DQ375880 DQ375881 DQ375882 DQ375883 DQ375884 DQ375885 DQ375886 DQ375887 DQ375888 DQ375889 DQ375890 DQ375891 DQ375892 DQ375893 DQ375894 DQ375895 DQ375896 DQ375897 DQ375898 DQ375899 DQ375900 DQ375901 DQ375902 DQ375903 DQ375904 DQ375905 DQ375906 DQ375907 DQ375908 DQ375909 DQ375910 DQ375911 DQ375912 DQ375913 DQ375914 DQ375915 DQ375916 DQ375917 DQ375918 DQ375919 DQ375920 DQ375921 DQ375922 DQ375923 DQ375924 DQ375925 DQ375926 DQ375927 DQ375928 DQ375929 DQ375930 DQ375931 DQ375932 DQ375933 DQ375934 DQ375935 DQ375936 DQ375937 DQ375938 DQ375939 DQ375940 DQ375941 DQ375942 DQ375943 DQ375944 DQ375945 DQ375946 DQ375947 DQ375948 DQ375949 DQ375950 DQ375951 DQ375952 DQ375953 DQ375954 DQ375955 DQ375956 DQ375957 DQ375958 DQ375959 DQ375960 DQ375961 DQ375962 DQ375963 DQ375964 DQ375965 DQ375966 DQ375967 DQ375968 DQ375969 DQ375970 DQ375971 DQ375972 DQ375973 DQ375974 DQ375975 DQ375976 DQ375977 DQ375978 DQ375979 DQ375980 DQ375981 DQ375982 DQ375983 DQ375984 DQ375985 Entrez Gene - A searchable database of RefSeq genes. • 48805 UniProtKB/Swiss-Prot • Q9V3A4 UniProtKB/TrEMBL • Q2EJA5 Q2EJB1 Q2EJB6 Q2EJB7 Q2EJC0 Q2EJD1 Q2EJD4 Q2EJD6 Q2EJD8 Q2EJE1 Q2EJE2 Q2EJE6 Q2EJE9 Q2EJF2 Q2EJF3 Q2EJF5 Q2EJG6 Q2EJH2 Q2EJI9 Q2EJJ6 Q2EJJ7 Q2EJK8 Q2EJK9 Q2EJL0 Q2EJL5 Q2EJL9 Q2EJM0 Q2EJM1 Q2EJM5 Q2EJM6 Q2EJN0 Q2EJN2 Q2EJP0 Q2EJP2 Q2EJP5 Q2EJQ0 Q2EJQ2 Q2EJQ4 Q2EJQ6 Q2EJQ7 Q2EJQ8 Q2EJQ9 Q2EJR0 Q2EJR1 Q2EJR3 Q2EJR5 Q2EJR6 Q2EJR7 Q2EJS1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc/iron permease (IPR003689)
Linkouts
	BioGRID - A database of protein and genetic interactions • 71703 DroID - A comprehensive database of gene and protein interactions. • FBgn0002022 DRSC - Results from RNAi screens. • FBgn0002022 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002022 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10449-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0002022 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 48805 InParanoid A subset of ortholog calls from InParanoid. • AAEL001968-PA Aedes aegypti (mosquito) AGAP008034-PA Anopheles gambiae (mosquito) XP_395560.2 Apis mellifera (honey bee) XP_001949272.1 Acyrthosiphon pisum (pea aphid) At1g68100.1 Arabidopsis thaliana (wall cress) 124484 Branchiostoma floridae (lancelet) XP_001894219.1 Brugia malayi (roundworm nematode) BGIBMGA002971-PA Bombyx mori (silk worm) ENSBTAP00000050674 Bos taurus (bovine) CN09907 Caenorhabditis brenneri (small nematode) CBP26486 Caenorhabditis briggsae (nematode) CE38718 Caenorhabditis elegans (worm) ENSCAFP00000001312 Canis familiaris (dog) CAGL0I05280g Candida glabrata (haploid yeast) ENSCINP00000017027 Ciona intestinalis (sea squirt) JA10634 Caenorhabditis japonica (nematode) CMP282C Cyanidioschyzon merolae (red alga) cn03120 Cryptococcus neoformans (yeast-like fungus) CPIJ008087 Culex pipens (mosquito) ENSCPOP00000017364 Cavia porcellus (guinea pig) RP22705 Caenorhabditis remanei (nematode) 24325 Capitella spl (polychaete worm) 220710 Daphnia pulex (daphnia) ENSDARP00000052863 Danio rerio (zebra fish) ENSECAP00000003850 Equus caballus (horse) 185976 Hypsipyla robusta (cedar shoot borer) ENSP00000363809 Homo sapiens (human) ENSP00000372560 Homo sapiens (human) ENSP00000372701 Homo sapiens (human) ISCW017090-PA Ixodes scapularis (deer tick) KLLA0F17886g Kluyveromyces lactis (yeast) 94834 Lottia gigantea (owl limpet) ENSMODP00000017798 Monodelphis domestica (gray opossum) ENSMMUP00000005149 Macaca mulatta (rhesus monkey) ENSMUSP00000025186 Mus musculus (house mouse) 241132 Nematostella vectensis (starlet anemone) XP_001605825.1 Nasonia vitripennis (wasp) ENSORLP00000007374 Oryzias latipes (japanese killifish) LOC_Os08g36420.1 Oryza sativa (asian rice) PHUM001836-PA Pediculus humanus (human body louse) PP06118 Pristionchus pacificus (nematode) 98954 Physcomitrella patens (moss) ENSPPYP00000019325 Pongo pygmaeus (orangutan) 82538 Phytophthora ramorum (sudden oak death pathogen) 720768 Populus trichocarpa (black cottonwood) ENSPTRP00000030803 Pan troglodytes (chimpanzee) ENSRNOP00000000541 Rattus norvegicus (norway rat) 5058832 Sorghum bicolor (sorghum) Smp_139720 Schistosoma mansoni (trematode parasite) SPAP8A3.03 Schizosaccharomyces pombe (fission yeast) XP_787748.1 Strongylocentrotus purpuratus (purple sea urchin) 20426 Trichoplax adhaerens (metazoa) XP_974198.1 Tribolium castaneum (red flour beetle) ENSTNIP00000021341 Tetraodon nigroviridis (green spotted pufferfish) 260850 Thalassiosira pseudonana (marine diatom) ENSTRUP00000007706 Takifugu rubripes (pufferfish Takifugu) 220.m00041 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000043930 Xenopus tropicalis (frog) YALI0F04312g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 48805 modMine - Data generated by the modENCODE project. • FBgn0002022 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14914 NV11665 LH22473 ISCW017090 FBgn0230918 FBgn0226127 FBgn0198860 FBgn0084332 FBgn0172226 JGI_V11_220710 FBgn0070382 FBgn0156512 FBgn0135821 FBgn0118372 FBgn0113334 FBgn0091719 CPIJ008087 BGIBMGA002971 ACYPI004908 GB12946 AGAP008034 AAEL001968 PHUM463380 GLEAN_13479
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	Bc (Thor and Thomas, 1997, Wright, 1996, McCrady and Tolin, 1994) Catecholamines up (Edwards et al., 2006) Catsup (Jordan et al., 2006, Ferdousy et al., 2007, Inamdar et al., 2007, Carbone et al., 2006, McCrady and Tolin, 1994, Christensen and Cook, 2007.3.22, Christensen and Cook, 2007.10.29, Wright and O'Donnell, 2008, Ferdousy et al., 2008, Dietzl et al., 2007, Carrasco-Rando and Ruiz-Gómez, 2008, Chaudhuri et al., 2007, Harbison et al., 2009, Wicker-Thomas and Hamann, 2008, Hsouna et al., 2007, Roshina and Pasyukova, 2007, Gutiérrez et al., 2010, Loeschcke et al., 2011) catsup (Wang et al., 2006) CG10449 (Keleman et al., 2009.8.5) dCATSUP (Mathews et al., 2005) fs(2)ltoQT50   l(2)37Bc (Thor et al., 1999, Stathakis et al., 1995, Lemaitre et al., 1995, Pentz et al., 1986, Gilbert et al., 1984, Wright et al., 1981, Wright, 1987) l(2)E13 (Wright et al., 1976, ) l(2)k05402 (Mesilaty-Gross et al., 1999) l(2)k05424 (Spradling et al., 1999, )
Name Synonym	Catecholamines up (Edwards et al., 2006, Jordan et al., 2006, Carbone et al., 2006, Wright and O'Donnell, 2008, Ferdousy et al., 2008, Harbison et al., 2009, Hsouna et al., 2007, Gutiérrez et al., 2010) catsup (Edwards and Mackay, 2004)
Secondary FlyBase IDs
	FBgn0022172 FBgn0032743
References ( 80 )
Generate a list of	All references relating to this gene ( 80 )
List References by type	Research paper  ( 30 ) Supplementary material  ( 4 ) Review  ( 2 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 26 ) FlyBase analysis  ( 2 ) Computer file  ( 4 ) Protein sequence record  ( 1 ) DNA/RNA sequence record  ( 1 ) Automatic genome annotation  ( 1 ) Book  ( 1 )
Recent research papers ( 2 )
	Loeschcke et al., 2011, J. Insect Physiol. 57(9): 1227--1231 Consistent effects of a major QTL for thermal resistance in field-released Drosophila melanogaster. [FBrf0215035] Gutiérrez et al., 2010, FEBS Lett. 584(13): 2942--2946 Zinc accumulation in heterozygous mutants of fumble, the pantothenate kinase homologue of Drosophila. [FBrf0211028] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...