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Gene Dmel\l(2)37Cc

General Information
Symbol	Dmel\l(2)37Cc	Species	D. melanogaster
Name	lethal (2) 37Cc	Annotation symbol	CG10691
Feature type	protein_coding_gene	FlyBase ID	FBgn0002031
Gene Model Status	Current	Stock availability	14 publicly available
Also Known As	Cc
Genomic Location
Chromosome (arm)	2L	Recombination map	2-53.9+
Cytogenetic map	37C1-37C1	Sequence location	2L:19,122,040..19,123,869 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene lethal (2) 37Cc is referred to in FlyBase by the symbol Dmel\l(2)37Cc (CG10691, FBgn0002031). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: cellular response to hypoxia. 43 alleles are reported. The phenotypes of these alleles are annotated with: yolk; cystocyte; trichogen cell; egg; macrochaeta; mesothoracic tergum; wing; egg chamber. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Band 7 protein; Prohibitin. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, during late pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult brain, larval Malpighian tubules, larval fat body. Comments on Affy2 ProbeSet: ProbeSet 1630771_s_at completely aligns to an exonic region common to each of the 3 FlyBase-annotated transcript isoforms of l(2)37Cc. Gene sequence location is 2L:19122040..19123869.
User Contributed Data
	Beta version, feedback welcome
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	l(2)37Cc Many different complementing heteroallelic genotypes exhibit opaque wings, often incompletely expanded, moderate Minute-like bristles, and a lighter tan body color.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 37C1-37C1   Limits computationally determined from genome sequence between P{lacW}Ddck02104 and P{lacW}bratk06028&P{lacW}l(2)k09613k09613
Experimentally Determined Cytological Location
Cytogenetic map Notes References 37C-37C   (determined by in situ hybridisation)   (Eveleth and Marsh, 1986)
Experimentally Determined Recombination Data
Location	2-53.9+
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\l(2)37Cc for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) l(2)37Cc-RA FBtr0081165  NM_165281   1311   276 l(2)37Cc-RB FBtr0081164  NM_057259   1327   276
Additional Transcript Data & Comments
Reported size (kB)	1.6 (northern blot) (Eveleth and Marsh, 1986)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein l(2)37Cc-PA   FBpp0080708   30.4   276   5.44     NP_724165   AAN11026 l(2)37Cc-PB   FBpp0080707   30.4   276   5.44     NP_476607   AAF53765
Additional Polypeptide Data & Comments
Reported size (kDa)	203 (aa) (Eveleth and Marsh, 1986)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Prohibitin (IPR000163) Band 7 protein (IPR001107)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA263314   AA392650   AA694954   AA695082   AA695254   AA695558   AA695860   AA735838   AA736099   AA803969   AE014134 AAF53765   AE014134 AAN11026   AC005440   AC007176   AI134881   AI454958   AI531203   AI543997   AI546694   AI945443   AI945771   AW940465   AY122111 AAM52623   BE662203   BE976646   BE977300   BF486295   BF487825   BF488087   BF495098   BF499851   BF501787   BF502191   BG632650   BG635747   BG636303   BG641188   BI163781   BI164792   BI231080   BI232133   BI234884   BI235405   BI238139   BI242263   BI352190   BI353073   BI355268   BI355740   BI369213   BI484716   BI565085   BI578615   BI580177   BI606093   BI618822   BI630438   BP554060   BP554061   BQ102949   BQ103021   CK131195   CK659677   CO176892   CO178942   CO186074   CO267333   CO270178   CO294771   CO302500   CO306995   CO318136   DQ440281   EC077476   EC080192   EC087023   EC195873   EC205869   EC220129   EC226160   EC250056   EL880846   EL880957   EV580259   EV582947   EV584329   EV586717   EV591001   EV596320   EV598189   FE863515   FE863590   FE863645   FE863670   FE863721   FE863775   FE863834   FE863901   GH745543   GH746436   GH747035   GH766676   X04227 CAA27807   X04228 CAA27810
UniProtKB/Swiss-Prot	P24156
UniProtKB/TrEMBL	E1JHL5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 7 -- 8   organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) somatic muscle primordium   (Fisher et al., 2012) Comment:reported as muscle system primordium visceral muscle primordium   (Fisher et al., 2012) Comment:reported as muscle system primordium trunk mesoderm   (Fisher et al., 2012) embryonic stage 13 -- 16   dorsal pharyngeal muscle   (Fisher et al., 2012) embryonic anal pad   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012) embryonic/larval somatic muscle   (Fisher et al., 2012) embryonic/larval visceral muscle   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage & larval stage & adult stage     (Eveleth and Marsh, 1986)
Additional Descriptive Data
	l(2)37Cc transcripts are observed on northern blots in RNA from early and late embryos, third instar larvae, and adults. They are most abundant at the late embryo stage. (Eveleth and Marsh, 1986)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cytoplasm inferred from direct assay (Beller et al., 2006) lipid particle inferred from direct assay (Beller et al., 2006, Beller et al., 2006, Cermelli et al., 2006) microtubule associated complex inferred from direct assay (Hughes et al., 2008) mitochondrion inferred from direct assay (Konrad and Marsh, 1991, Alonso et al., 2005)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult brain, larval Malpighian tubules, larval fat body. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    778.525 Larval Midgut    568 Larval Hindgut    980.8 Larval Malpighian Tubules    444.5 Larval Fat Body    494.8 Larval Salivary Gland    784.1 Larval Trachea    688.55 Larval Carcass    775.225 Adult Head    394.5 Adult Eye    458.875 Adult Brain    411.2 Adult Thoracic-Abdominal Ganglion    555 Adult Crop    669.3 Adult Midgut    712.8 Adult Hindgut    800.9 Adult Malpighian Tubules    1116.8 Adult Fat Body    863.2 Adult Salivary Gland    536.9 Adult Heart    524.05 Adult VirginFemale Spermatheca    1183.1 Adult InseminatedFemale Spermatheca    1331.8 Adult Ovary    1062.2 Adult Testis    670.1 Adult Male Accessory Gland    667.6 Adult Carcass    576.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (778.525) Larval Midgut  (568) Larval Hindgut  (980.8) Larval Malpighian Tubules    444.5 Larval Fat Body    494.8 Larval Salivary Gland  (784.1) Larval Trachea  (688.55) Larval Carcass  (775.225) Adult Head    394.5 Adult Eye    458.875 Adult Brain    411.2 Adult Thoracic-Abdominal Ganglion  (555) Adult Crop  (669.3) Adult Midgut  (712.8) Adult Hindgut  (800.9) Adult Malpighian Tubules  (1116.8) Adult Fat Body  (863.2) Adult Salivary Gland  536.9 Adult Heart  524.05 Adult VirginFemale Spermatheca  (1183.1) Adult InseminatedFemale Spermatheca  (1331.8) Adult Ovary  (1062.2) Adult Testis  (670.1) Adult Male Accessory Gland  (667.6) Adult Carcass  (576.8) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    778.525 Larval Midgut    568 Larval Hindgut    980.8 Larval Malpighian Tubules    444.5 Larval Fat Body    494.8 Larval Salivary Gland    784.1 Larval Trachea    688.55 Larval Carcass    775.225 Adult Head    394.5 Adult Eye    458.875 Adult Brain    411.2 Adult Thoracic-Abdominal Ganglion    555 Adult Crop    669.3 Adult Midgut    712.8 Adult Hindgut    800.9 Adult Malpighian Tubules  (1116.8) Adult Fat Body    863.2 Adult Salivary Gland    536.9 Adult Heart    524.05 Adult VirginFemale Spermatheca  (1183.1) Adult InseminatedFemale Spermatheca  (1331.8) Adult Ovary  1062.2 Adult Testis    670.1 Adult Male Accessory Gland    667.6 Adult Carcass    576.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    778.525 Larval Midgut    568 Larval Hindgut    980.8 Larval Malpighian Tubules    444.5 Larval Fat Body    494.8 Larval Salivary Gland    784.1 Larval Trachea    688.55 Larval Carcass    775.225 Adult Head    394.5 Adult Eye    458.875 Adult Brain    411.2 Adult Thoracic-Abdominal Ganglion    555 Adult Crop    669.3 Adult Midgut    712.8 Adult Hindgut    800.9 Adult Malpighian Tubules    1116.8 Adult Fat Body    863.2 Adult Salivary Gland    536.9 Adult Heart    524.05 Adult VirginFemale Spermatheca    1183.1 Adult InseminatedFemale Spermatheca    1331.8 Adult Ovary    1062.2 Adult Testis    670.1 Adult Male Accessory Gland    667.6 Adult Carcass    576.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    778.525 Larval Midgut    568 Larval Hindgut    980.8 Larval Malpighian Tubules    444.5 Larval Fat Body    494.8 Larval Salivary Gland    784.1 Larval Trachea    688.55 Larval Carcass    775.225 Adult Head    394.5 Adult Eye    458.875 Adult Brain    411.2 Adult Thoracic-Abdominal Ganglion    555 Adult Crop    669.3 Adult Midgut    712.8 Adult Hindgut    800.9 Adult Malpighian Tubules    1116.8 Adult Fat Body    863.2 Adult Salivary Gland    536.9 Adult Heart    524.05 Adult VirginFemale Spermatheca    1183.1 Adult InseminatedFemale Spermatheca    1331.8 Adult Ovary    1062.2 Adult Testis    670.1 Adult Male Accessory Gland    667.6 Adult Carcass    576.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  778.525 Larval Midgut  568 Larval Hindgut  (980.8) Larval Malpighian Tubules    444.5 Larval Fat Body    494.8 Larval Salivary Gland  784.1 Larval Trachea  688.55 Larval Carcass  775.225 Adult Head    394.5 Adult Eye    458.875 Adult Brain    411.2 Adult Thoracic-Abdominal Ganglion  555 Adult Crop  669.3 Adult Midgut  712.8 Adult Hindgut  800.9 Adult Malpighian Tubules  (1116.8) Adult Fat Body  (863.2) Adult Salivary Gland  536.9 Adult Heart  524.05 Adult VirginFemale Spermatheca  (1183.1) Adult InseminatedFemale Spermatheca  (1331.8) Adult Ovary  (1062.2) Adult Testis  670.1 Adult Male Accessory Gland  667.6 Adult Carcass  576.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    778.525 Larval Midgut    568 Larval Hindgut    980.8 Larval Malpighian Tubules    444.5 Larval Fat Body    494.8 Larval Salivary Gland    784.1 Larval Trachea    688.55 Larval Carcass    775.225 Adult Head    394.5 Adult Eye    458.875 Adult Brain    411.2 Adult Thoracic-Abdominal Ganglion    555 Adult Crop    669.3 Adult Midgut    712.8 Adult Hindgut    800.9 Adult Malpighian Tubules  1116.8 Adult Fat Body    863.2 Adult Salivary Gland    536.9 Adult Heart    524.05 Adult VirginFemale Spermatheca  1183.1 Adult InseminatedFemale Spermatheca  1331.8 Adult Ovary  1062.2 Adult Testis    670.1 Adult Male Accessory Gland    667.6 Adult Carcass    576.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    778.525 Larval Midgut    568 Larval Hindgut    980.8 Larval Malpighian Tubules    444.5 Larval Fat Body    494.8 Larval Salivary Gland    784.1 Larval Trachea    688.55 Larval Carcass    775.225 Adult Head    394.5 Adult Eye    458.875 Adult Brain    411.2 Adult Thoracic-Abdominal Ganglion    555 Adult Crop    669.3 Adult Midgut    712.8 Adult Hindgut    800.9 Adult Malpighian Tubules    1116.8 Adult Fat Body    863.2 Adult Salivary Gland    536.9 Adult Heart    524.05 Adult VirginFemale Spermatheca    1183.1 Adult InseminatedFemale Spermatheca    1331.8 Adult Ovary    1062.2 Adult Testis    670.1 Adult Male Accessory Gland    667.6 Adult Carcass    576.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    394.5   NA  Eye    458.875   NA  Brain    411.2   778.525  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    555   NA  Crop    669.3   568  Midgut    712.8   980.8  Hindgut    800.9   444.5  Malpighian Tubules    1116.8   494.8  Fat Body    863.2   784.1  Salivary Gland    536.9   NA  Heart    524.05   688.55  Trachea    NA   NA  VirginFemale Spermatheca    1183.1   NA  InseminatedFemale Spermatheca    1331.8   NA  Ovary    1062.2   NA  Testis    670.1   NA  Male Accessory Gland    667.6   775.225  Carcass    576.8 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    73 central nervous system, larvae L3    30 central nervous system, pupae P8    30 head, virgin 1-day female    18 head, virgin 4-day female    18 head, virgin 20-day female    26 head, mated 1-day female    17 head, mated 4-day female    21 head, mated 20-day female    19 head, mated 1-day male    22 head, mated 4-day male    24 head, mated 20-day male    21 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    26 digestive system, 1-day adult    36 digestive system, 4-day adult    35 digestive system, 20-day adult    31 fat body, larvae L3 wandering    11 fat body, white prepupae    16 fat body, pupae P8    43 carcass, larvae L3 wandering    29 carcass, 1-day adult    18 carcass, 4-day adult    25 carcass, 20-day adult    24 ovary, virgin 4-day female    91 ovary, mated 4-day female    73 testis, mated 4-day male    65 accessory gland, mated 4-day male    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (73) central nervous system, larvae L3  (30) central nervous system, pupae P8  (30) head, virgin 1-day female    18 head, virgin 4-day female    18 head, virgin 20-day female  26 head, mated 1-day female    17 head, mated 4-day female    21 head, mated 20-day female    19 head, mated 1-day male    22 head, mated 4-day male    24 head, mated 20-day male    21 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    5 digestive system, larvae L3 wandering  26 digestive system, 1-day adult  (36) digestive system, 4-day adult  (35) digestive system, 20-day adult  (31) fat body, larvae L3 wandering    11 fat body, white prepupae    16 fat body, pupae P8  (43) carcass, larvae L3 wandering  (29) carcass, 1-day adult    18 carcass, 4-day adult    25 carcass, 20-day adult    24 ovary, virgin 4-day female  (91) ovary, mated 4-day female  (73) testis, mated 4-day male  (65) accessory gland, mated 4-day male    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    73 central nervous system, larvae L3    30 central nervous system, pupae P8    30 head, virgin 1-day female    18 head, virgin 4-day female    18 head, virgin 20-day female    26 head, mated 1-day female    17 head, mated 4-day female    21 head, mated 20-day female    19 head, mated 1-day male    22 head, mated 4-day male    24 head, mated 20-day male    21 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    26 digestive system, 1-day adult    36 digestive system, 4-day adult    35 digestive system, 20-day adult    31 fat body, larvae L3 wandering    11 fat body, white prepupae    16 fat body, pupae P8    43 carcass, larvae L3 wandering    29 carcass, 1-day adult    18 carcass, 4-day adult    25 carcass, 20-day adult    24 ovary, virgin 4-day female    91 ovary, mated 4-day female    73 testis, mated 4-day male    65 accessory gland, mated 4-day male    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    73 central nervous system, larvae L3    30 central nervous system, pupae P8    30 head, virgin 1-day female    18 head, virgin 4-day female    18 head, virgin 20-day female    26 head, mated 1-day female    17 head, mated 4-day female    21 head, mated 20-day female    19 head, mated 1-day male    22 head, mated 4-day male    24 head, mated 20-day male    21 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    26 digestive system, 1-day adult    36 digestive system, 4-day adult    35 digestive system, 20-day adult    31 fat body, larvae L3 wandering    11 fat body, white prepupae    16 fat body, pupae P8    43 carcass, larvae L3 wandering    29 carcass, 1-day adult    18 carcass, 4-day adult    25 carcass, 20-day adult    24 ovary, virgin 4-day female    91 ovary, mated 4-day female    73 testis, mated 4-day male    65 accessory gland, mated 4-day male    24 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    73 central nervous system, larvae L3    30 central nervous system, pupae P8    30 head, virgin 1-day female    18 head, virgin 4-day female    18 head, virgin 20-day female    26 head, mated 1-day female    17 head, mated 4-day female    21 head, mated 20-day female    19 head, mated 1-day male    22 head, mated 4-day male    24 head, mated 20-day male    21 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    26 digestive system, 1-day adult    36 digestive system, 4-day adult    35 digestive system, 20-day adult    31 fat body, larvae L3 wandering    11 fat body, white prepupae    16 fat body, pupae P8    43 carcass, larvae L3 wandering    29 carcass, 1-day adult    18 carcass, 4-day adult    25 carcass, 20-day adult    24 ovary, virgin 4-day female    91 ovary, mated 4-day female    73 testis, mated 4-day male    65 accessory gland, mated 4-day male    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (73) central nervous system, larvae L3  30 central nervous system, pupae P8  30 head, virgin 1-day female    18 head, virgin 4-day female    18 head, virgin 20-day female  26 head, mated 1-day female    17 head, mated 4-day female    21 head, mated 20-day female    19 head, mated 1-day male    22 head, mated 4-day male    24 head, mated 20-day male    21 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    5 digestive system, larvae L3 wandering  26 digestive system, 1-day adult  (36) digestive system, 4-day adult  (35) digestive system, 20-day adult  31 fat body, larvae L3 wandering    11 fat body, white prepupae    16 fat body, pupae P8  (43) carcass, larvae L3 wandering  29 carcass, 1-day adult    18 carcass, 4-day adult    25 carcass, 20-day adult    24 ovary, virgin 4-day female  (91) ovary, mated 4-day female  (73) testis, mated 4-day male  (65) accessory gland, mated 4-day male    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    73 central nervous system, larvae L3    30 central nervous system, pupae P8    30 head, virgin 1-day female    18 head, virgin 4-day female    18 head, virgin 20-day female    26 head, mated 1-day female    17 head, mated 4-day female    21 head, mated 20-day female    19 head, mated 1-day male    22 head, mated 4-day male    24 head, mated 20-day male    21 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    26 digestive system, 1-day adult    36 digestive system, 4-day adult    35 digestive system, 20-day adult    31 fat body, larvae L3 wandering    11 fat body, white prepupae    16 fat body, pupae P8    43 carcass, larvae L3 wandering    29 carcass, 1-day adult    18 carcass, 4-day adult    25 carcass, 20-day adult    24 ovary, virgin 4-day female    91 ovary, mated 4-day female    73 testis, mated 4-day male    65 accessory gland, mated 4-day male    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    73 central nervous system, larvae L3    30 central nervous system, pupae P8    30 head, virgin 1-day female    18 head, virgin 4-day female    18 head, virgin 20-day female    26 head, mated 1-day female    17 head, mated 4-day female    21 head, mated 20-day female    19 head, mated 1-day male    22 head, mated 4-day male    24 head, mated 20-day male    21 salivary gland, larvae L3 wandering    3 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    26 digestive system, 1-day adult    36 digestive system, 4-day adult    35 digestive system, 20-day adult    31 fat body, larvae L3 wandering    11 fat body, white prepupae    16 fat body, pupae P8    43 carcass, larvae L3 wandering    29 carcass, 1-day adult    18 carcass, 4-day adult    25 carcass, 20-day adult    24 ovary, virgin 4-day female    91 ovary, mated 4-day female    73 testis, mated 4-day male    65 accessory gland, mated 4-day male    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, during late pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    231 embryo 02-04hr    68 embryo 04-06hr    42 embryo 06-08hr    83 embryo 08-10hr    114 embryo 10-12hr    193 embryo 12-14hr    137 embryo 14-16hr    227 embryo 16-18hr    200 embryo 18-20hr    165 embryo 20-22hr    158 embryo 22-24hr    128 larva L1    301 larva L2    261 larva L3 12hr old    201 larva L3 puffstage 1-2    80 larva L3 puffstage 3-6    78 larva L3 puffstage 7-9    84 white prepupae new    71 white prepupae 12hr    68 white prepupae 24hr    87 pupae 2d postWPP    152 pupae 3d postWPP    139 pupae 4d postWPP    99 adult male 01day    98 adult male 05day    113 adult male 30day    121 adult female 01day    190 adult female 05day    203 adult female 30day    207 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (231) embryo 02-04hr  (68) embryo 04-06hr  (42) embryo 06-08hr  (83) embryo 08-10hr  (114) embryo 10-12hr  (193) embryo 12-14hr  (137) embryo 14-16hr  (227) embryo 16-18hr  (200) embryo 18-20hr  (165) embryo 20-22hr  (158) embryo 22-24hr  (128) larva L1  (301) larva L2  (261) larva L3 12hr old  (201) larva L3 puffstage 1-2  (80) larva L3 puffstage 3-6  (78) larva L3 puffstage 7-9  (84) white prepupae new  (71) white prepupae 12hr  (68) white prepupae 24hr  (87) pupae 2d postWPP  (152) pupae 3d postWPP  (139) pupae 4d postWPP  (99) adult male 01day  (98) adult male 05day  (113) adult male 30day  (121) adult female 01day  (190) adult female 05day  (203) adult female 30day  (207) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (231) embryo 02-04hr    68 embryo 04-06hr    42 embryo 06-08hr    83 embryo 08-10hr  (114) embryo 10-12hr  (193) embryo 12-14hr  (137) embryo 14-16hr  (227) embryo 16-18hr  (200) embryo 18-20hr  (165) embryo 20-22hr  (158) embryo 22-24hr  (128) larva L1  (301) larva L2  (261) larva L3 12hr old  (201) larva L3 puffstage 1-2    80 larva L3 puffstage 3-6    78 larva L3 puffstage 7-9    84 white prepupae new    71 white prepupae 12hr    68 white prepupae 24hr    87 pupae 2d postWPP  (152) pupae 3d postWPP  (139) pupae 4d postWPP    99 adult male 01day    98 adult male 05day  (113) adult male 30day  (121) adult female 01day  (190) adult female 05day  (203) adult female 30day  (207) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    231 embryo 02-04hr    68 embryo 04-06hr    42 embryo 06-08hr    83 embryo 08-10hr    114 embryo 10-12hr    193 embryo 12-14hr    137 embryo 14-16hr    227 embryo 16-18hr    200 embryo 18-20hr    165 embryo 20-22hr    158 embryo 22-24hr    128 larva L1    301 larva L2    261 larva L3 12hr old    201 larva L3 puffstage 1-2    80 larva L3 puffstage 3-6    78 larva L3 puffstage 7-9    84 white prepupae new    71 white prepupae 12hr    68 white prepupae 24hr    87 pupae 2d postWPP    152 pupae 3d postWPP    139 pupae 4d postWPP    99 adult male 01day    98 adult male 05day    113 adult male 30day    121 adult female 01day    190 adult female 05day    203 adult female 30day    207 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    231 embryo 02-04hr    68 embryo 04-06hr    42 embryo 06-08hr    83 embryo 08-10hr    114 embryo 10-12hr    193 embryo 12-14hr    137 embryo 14-16hr    227 embryo 16-18hr    200 embryo 18-20hr    165 embryo 20-22hr    158 embryo 22-24hr    128 larva L1    301 larva L2    261 larva L3 12hr old    201 larva L3 puffstage 1-2    80 larva L3 puffstage 3-6    78 larva L3 puffstage 7-9    84 white prepupae new    71 white prepupae 12hr    68 white prepupae 24hr    87 pupae 2d postWPP    152 pupae 3d postWPP    139 pupae 4d postWPP    99 adult male 01day    98 adult male 05day    113 adult male 30day    121 adult female 01day    190 adult female 05day    203 adult female 30day    207 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (231) embryo 02-04hr  (68) embryo 04-06hr  (42) embryo 06-08hr  (83) embryo 08-10hr  (114) embryo 10-12hr  (193) embryo 12-14hr  (137) embryo 14-16hr  (227) embryo 16-18hr  (200) embryo 18-20hr  (165) embryo 20-22hr  (158) embryo 22-24hr  (128) larva L1  (301) larva L2  (261) larva L3 12hr old  (201) larva L3 puffstage 1-2  (80) larva L3 puffstage 3-6  (78) larva L3 puffstage 7-9  (84) white prepupae new  (71) white prepupae 12hr  (68) white prepupae 24hr  (87) pupae 2d postWPP  (152) pupae 3d postWPP  (139) pupae 4d postWPP  (99) adult male 01day  (98) adult male 05day  (113) adult male 30day  (121) adult female 01day  (190) adult female 05day  (203) adult female 30day  (207) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (231) embryo 02-04hr    68 embryo 04-06hr    42 embryo 06-08hr    83 embryo 08-10hr  114 embryo 10-12hr  (193) embryo 12-14hr  137 embryo 14-16hr  (227) embryo 16-18hr  (200) embryo 18-20hr  (165) embryo 20-22hr  (158) embryo 22-24hr  128 larva L1  (301) larva L2  (261) larva L3 12hr old  (201) larva L3 puffstage 1-2    80 larva L3 puffstage 3-6    78 larva L3 puffstage 7-9    84 white prepupae new    71 white prepupae 12hr    68 white prepupae 24hr    87 pupae 2d postWPP  (152) pupae 3d postWPP  139 pupae 4d postWPP    99 adult male 01day    98 adult male 05day  113 adult male 30day  121 adult female 01day  (190) adult female 05day  (203) adult female 30day  (207) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    231 embryo 02-04hr    68 embryo 04-06hr    42 embryo 06-08hr    83 embryo 08-10hr    114 embryo 10-12hr    193 embryo 12-14hr    137 embryo 14-16hr    227 embryo 16-18hr    200 embryo 18-20hr    165 embryo 20-22hr    158 embryo 22-24hr    128 larva L1    301 larva L2    261 larva L3 12hr old    201 larva L3 puffstage 1-2    80 larva L3 puffstage 3-6    78 larva L3 puffstage 7-9    84 white prepupae new    71 white prepupae 12hr    68 white prepupae 24hr    87 pupae 2d postWPP    152 pupae 3d postWPP    139 pupae 4d postWPP    99 adult male 01day    98 adult male 05day    113 adult male 30day    121 adult female 01day    190 adult female 05day    203 adult female 30day    207 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    95 Schneider line 2 Sg4    109 embryonic 1182-4H    147 embryonic GM2    149 embryonic Kc167    308 embryonic S1    210 embryonic S3    116 leg disc CME L1    106 wing disc CME-W2    148 wing disc ML-DmD8    122 wing disc ML-DmD9    200 wing disc ML-DmD16-c3    143 wing disc ML-DmD21    169 wing disc ML-DmD32    108 haltere disc ML-DmD17-c3    138 eye-antennal disc ML-DmD11    205 antennal disc ML-DmD20-c5    188 mixed discs ML-DmD4-c1    113 CNS ML-DmBG1-c1    188 CNS ML-DmBG2-c2    326 tumorous blood cells mbn2    159 ovary fGS/OSS    46 ovary OSC    115 ovary OSS    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (95) Schneider line 2 Sg4  (109) embryonic 1182-4H  (147) embryonic GM2  (149) embryonic Kc167  (308) embryonic S1  (210) embryonic S3  (116) leg disc CME L1  (106) wing disc CME-W2  (148) wing disc ML-DmD8  (122) wing disc ML-DmD9  (200) wing disc ML-DmD16-c3  (143) wing disc ML-DmD21  (169) wing disc ML-DmD32  (108) haltere disc ML-DmD17-c3  (138) eye-antennal disc ML-DmD11  (205) antennal disc ML-DmD20-c5  (188) mixed discs ML-DmD4-c1  (113) CNS ML-DmBG1-c1  (188) CNS ML-DmBG2-c2  (326) tumorous blood cells mbn2  (159) ovary fGS/OSS  (46) ovary OSC  (115) ovary OSS  (31) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    95 Schneider line 2 Sg4  (109) embryonic 1182-4H  (147) embryonic GM2  (149) embryonic Kc167  (308) embryonic S1  (210) embryonic S3  (116) leg disc CME L1  106 wing disc CME-W2  (148) wing disc ML-DmD8  (122) wing disc ML-DmD9  (200) wing disc ML-DmD16-c3  (143) wing disc ML-DmD21  (169) wing disc ML-DmD32  (108) haltere disc ML-DmD17-c3  (138) eye-antennal disc ML-DmD11  (205) antennal disc ML-DmD20-c5  (188) mixed discs ML-DmD4-c1  (113) CNS ML-DmBG1-c1  (188) CNS ML-DmBG2-c2  (326) tumorous blood cells mbn2  (159) ovary fGS/OSS    46 ovary OSC  (115) ovary OSS    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    95 Schneider line 2 Sg4    109 embryonic 1182-4H    147 embryonic GM2    149 embryonic Kc167    308 embryonic S1    210 embryonic S3    116 leg disc CME L1    106 wing disc CME-W2    148 wing disc ML-DmD8    122 wing disc ML-DmD9    200 wing disc ML-DmD16-c3    143 wing disc ML-DmD21    169 wing disc ML-DmD32    108 haltere disc ML-DmD17-c3    138 eye-antennal disc ML-DmD11    205 antennal disc ML-DmD20-c5    188 mixed discs ML-DmD4-c1    113 CNS ML-DmBG1-c1    188 CNS ML-DmBG2-c2    326 tumorous blood cells mbn2    159 ovary fGS/OSS    46 ovary OSC    115 ovary OSS    31 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    95 Schneider line 2 Sg4    109 embryonic 1182-4H    147 embryonic GM2    149 embryonic Kc167    308 embryonic S1    210 embryonic S3    116 leg disc CME L1    106 wing disc CME-W2    148 wing disc ML-DmD8    122 wing disc ML-DmD9    200 wing disc ML-DmD16-c3    143 wing disc ML-DmD21    169 wing disc ML-DmD32    108 haltere disc ML-DmD17-c3    138 eye-antennal disc ML-DmD11    205 antennal disc ML-DmD20-c5    188 mixed discs ML-DmD4-c1    113 CNS ML-DmBG1-c1    188 CNS ML-DmBG2-c2    326 tumorous blood cells mbn2    159 ovary fGS/OSS    46 ovary OSC    115 ovary OSS    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (95) Schneider line 2 Sg4  (109) embryonic 1182-4H  (147) embryonic GM2  (149) embryonic Kc167  (308) embryonic S1  (210) embryonic S3  (116) leg disc CME L1  (106) wing disc CME-W2  (148) wing disc ML-DmD8  (122) wing disc ML-DmD9  (200) wing disc ML-DmD16-c3  (143) wing disc ML-DmD21  (169) wing disc ML-DmD32  (108) haltere disc ML-DmD17-c3  (138) eye-antennal disc ML-DmD11  (205) antennal disc ML-DmD20-c5  (188) mixed discs ML-DmD4-c1  (113) CNS ML-DmBG1-c1  (188) CNS ML-DmBG2-c2  (326) tumorous blood cells mbn2  (159) ovary fGS/OSS  (46) ovary OSC  (115) ovary OSS  31 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    95 Schneider line 2 Sg4  109 embryonic 1182-4H  (147) embryonic GM2  (149) embryonic Kc167  (308) embryonic S1  (210) embryonic S3  116 leg disc CME L1  106 wing disc CME-W2  (148) wing disc ML-DmD8  122 wing disc ML-DmD9  (200) wing disc ML-DmD16-c3  143 wing disc ML-DmD21  (169) wing disc ML-DmD32  108 haltere disc ML-DmD17-c3  138 eye-antennal disc ML-DmD11  (205) antennal disc ML-DmD20-c5  (188) mixed discs ML-DmD4-c1  113 CNS ML-DmBG1-c1  (188) CNS ML-DmBG2-c2  (326) tumorous blood cells mbn2  (159) ovary fGS/OSS    46 ovary OSC  115 ovary OSS    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    95 Schneider line 2 Sg4    109 embryonic 1182-4H    147 embryonic GM2    149 embryonic Kc167    308 embryonic S1    210 embryonic S3    116 leg disc CME L1    106 wing disc CME-W2    148 wing disc ML-DmD8    122 wing disc ML-DmD9    200 wing disc ML-DmD16-c3    143 wing disc ML-DmD21    169 wing disc ML-DmD32    108 haltere disc ML-DmD17-c3    138 eye-antennal disc ML-DmD11    205 antennal disc ML-DmD20-c5    188 mixed discs ML-DmD4-c1    113 CNS ML-DmBG1-c1    188 CNS ML-DmBG2-c2    326 tumorous blood cells mbn2    159 ovary fGS/OSS    46 ovary OSC    115 ovary OSS    31 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    25 cold shock, 4-day adult    24 heat shock, 4-day adult    69 Cadmium 50 mM 6 hrs, larvae L3    60 Cadmium 50 mM 12 hrs, larvae L3    44 Cadmium 50 mM 48 hrs, 4-day adult    67 Cadmium 100 mM 48 hrs, 4-day adult    74 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    85 Zinc 5 mM 12 hrs, larvae L3    26 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    106 Ethanol 5% 3 hrs, larvae L3    51 Ethanol 10% 3 hrs, larvae L3    54 Caffeine 1.5 mg/ml 4 hrs, larvae L3    42 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    76 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    77 Paraquat 10 mM 48 hrs, 4-day adult    102 Rotenone 2 μg 12 hrs, larvae L3    59 Rotenone 8 μg 12 hrs, larvae L3    105 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    25 cold shock, 4-day adult    24 heat shock, 4-day adult  (69) Cadmium 50 mM 6 hrs, larvae L3  (60) Cadmium 50 mM 12 hrs, larvae L3  (44) Cadmium 50 mM 48 hrs, 4-day adult  (67) Cadmium 100 mM 48 hrs, 4-day adult  (74) Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult  (85) Zinc 5 mM 12 hrs, larvae L3  26 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3  (106) Ethanol 5% 3 hrs, larvae L3  (51) Ethanol 10% 3 hrs, larvae L3  (54) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (42) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (76) Caffeine 25 mg/ml 48 hrs, 4-day adult  (33) Paraquat 5 mM 48 hrs, 4-day adult  (77) Paraquat 10 mM 48 hrs, 4-day adult  (102) Rotenone 2 μg 12 hrs, larvae L3  (59) Rotenone 8 μg 12 hrs, larvae L3  (105) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    25 cold shock, 4-day adult    24 heat shock, 4-day adult    69 Cadmium 50 mM 6 hrs, larvae L3    60 Cadmium 50 mM 12 hrs, larvae L3    44 Cadmium 50 mM 48 hrs, 4-day adult    67 Cadmium 100 mM 48 hrs, 4-day adult    74 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    85 Zinc 5 mM 12 hrs, larvae L3    26 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3  106 Ethanol 5% 3 hrs, larvae L3    51 Ethanol 10% 3 hrs, larvae L3    54 Caffeine 1.5 mg/ml 4 hrs, larvae L3    42 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    76 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    77 Paraquat 10 mM 48 hrs, 4-day adult  102 Rotenone 2 μg 12 hrs, larvae L3    59 Rotenone 8 μg 12 hrs, larvae L3  105 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    25 cold shock, 4-day adult    24 heat shock, 4-day adult    69 Cadmium 50 mM 6 hrs, larvae L3    60 Cadmium 50 mM 12 hrs, larvae L3    44 Cadmium 50 mM 48 hrs, 4-day adult    67 Cadmium 100 mM 48 hrs, 4-day adult    74 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    85 Zinc 5 mM 12 hrs, larvae L3    26 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    106 Ethanol 5% 3 hrs, larvae L3    51 Ethanol 10% 3 hrs, larvae L3    54 Caffeine 1.5 mg/ml 4 hrs, larvae L3    42 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    76 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    77 Paraquat 10 mM 48 hrs, 4-day adult    102 Rotenone 2 μg 12 hrs, larvae L3    59 Rotenone 8 μg 12 hrs, larvae L3    105 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    25 cold shock, 4-day adult    24 heat shock, 4-day adult    69 Cadmium 50 mM 6 hrs, larvae L3    60 Cadmium 50 mM 12 hrs, larvae L3    44 Cadmium 50 mM 48 hrs, 4-day adult    67 Cadmium 100 mM 48 hrs, 4-day adult    74 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    85 Zinc 5 mM 12 hrs, larvae L3    26 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    106 Ethanol 5% 3 hrs, larvae L3    51 Ethanol 10% 3 hrs, larvae L3    54 Caffeine 1.5 mg/ml 4 hrs, larvae L3    42 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    76 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    77 Paraquat 10 mM 48 hrs, 4-day adult    102 Rotenone 2 μg 12 hrs, larvae L3    59 Rotenone 8 μg 12 hrs, larvae L3    105 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    25 cold shock, 4-day adult    24 heat shock, 4-day adult  (69) Cadmium 50 mM 6 hrs, larvae L3  (60) Cadmium 50 mM 12 hrs, larvae L3  (44) Cadmium 50 mM 48 hrs, 4-day adult  (67) Cadmium 100 mM 48 hrs, 4-day adult  (74) Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult  (85) Zinc 5 mM 12 hrs, larvae L3  26 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3  (106) Ethanol 5% 3 hrs, larvae L3  (51) Ethanol 10% 3 hrs, larvae L3  (54) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (42) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (76) Caffeine 25 mg/ml 48 hrs, 4-day adult  (33) Paraquat 5 mM 48 hrs, 4-day adult  (77) Paraquat 10 mM 48 hrs, 4-day adult  (102) Rotenone 2 μg 12 hrs, larvae L3  (59) Rotenone 8 μg 12 hrs, larvae L3  (105) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    25 cold shock, 4-day adult    24 heat shock, 4-day adult    69 Cadmium 50 mM 6 hrs, larvae L3    60 Cadmium 50 mM 12 hrs, larvae L3    44 Cadmium 50 mM 48 hrs, 4-day adult    67 Cadmium 100 mM 48 hrs, 4-day adult    74 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    85 Zinc 5 mM 12 hrs, larvae L3    26 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3  106 Ethanol 5% 3 hrs, larvae L3    51 Ethanol 10% 3 hrs, larvae L3    54 Caffeine 1.5 mg/ml 4 hrs, larvae L3    42 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    76 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    77 Paraquat 10 mM 48 hrs, 4-day adult  102 Rotenone 2 μg 12 hrs, larvae L3    59 Rotenone 8 μg 12 hrs, larvae L3  105 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    25 cold shock, 4-day adult    24 heat shock, 4-day adult    69 Cadmium 50 mM 6 hrs, larvae L3    60 Cadmium 50 mM 12 hrs, larvae L3    44 Cadmium 50 mM 48 hrs, 4-day adult    67 Cadmium 100 mM 48 hrs, 4-day adult    74 Copper 0.5 mM 12 hrs, larvae L3    23 Copper 15 mM 48 hrs, 4-day adult    85 Zinc 5 mM 12 hrs, larvae L3    26 Zinc 4.5 mM 48 hrs, 4-day adult    25 Ethanol 2.5% 3 hrs, larvae L3    106 Ethanol 5% 3 hrs, larvae L3    51 Ethanol 10% 3 hrs, larvae L3    54 Caffeine 1.5 mg/ml 4 hrs, larvae L3    42 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    76 Caffeine 25 mg/ml 48 hrs, 4-day adult    33 Paraquat 5 mM 48 hrs, 4-day adult    77 Paraquat 10 mM 48 hrs, 4-day adult    102 Rotenone 2 μg 12 hrs, larvae L3    59 Rotenone 8 μg 12 hrs, larvae L3    105 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_19 mE1_20_mRNA_expression_cluster_10
External Data & Images
Linkouts	BDGP expression data • GH12454 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002031 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10691-RB FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for l(2)37Cc Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal l(2)37Cc10 l(2)37Cc15 lethal | heat sensitive l(2)37Cc6 l(2)37Ccts1 l(2)37Ccts2 lethal | larval stage l(2)37Cc7 l(2)37Cc14 lethal | larval stage | recessive l(2)37Cc7 l(2)37Cc10 l(2)37Cc14 lethal | recessive l(2)37Cc13 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 l(2)37CcGD5328 partially lethal - majority die | recessive | cold sensitive l(2)37Ccfs1 Sterility Allele female sterile l(2)37Cc6 l(2)37Cc15 l(2)37CcZ2-4450 l(2)37CcZ2-5051 female sterile | dominant l(2)37Cc13 female sterile | recessive l(2)37Ccfs1 male sterile l(2)37Cc6 l(2)37Cc15 Other Phenotypes Allele body color defective l(2)37Cc6 visible l(2)37Cc6 visible, with Scer\GAL4pnr-MD237 l(2)37CcGD5328 wild-type l(2)37Cc+t5.3 l(2)37Cc+t6.6 Phenotype manifest in Allele cystocyte l(2)37Cc13 egg l(2)37Cc13 l(2)37Ccfs1 egg chamber l(2)37Cc13 macrochaeta l(2)37Cc15 l(2)37Cc6 melanotic mass & adult abdomen l(2)37Cc23 mesothoracic tergum, with Scer\GAL4pnr-MD237 l(2)37CcGD5328 trichogen cell, with Scer\GAL4pnr-MD237 l(2)37CcGD5328 wing l(2)37Cc6 yolk l(2)37Cc13
Classical Alleles ( 31 )
For All Classical Alleles Show
Allele of l(2)37Cc Class Mutagen Stocks Known lesion l(2)37Cc20 diepoxybutane 2 Yes l(2)37Cc23 2 -- l(2)37Cc4 ethyl methanesulfonate 2 -- l(2)37Ccts1 ethyl methanesulfonate formaldehyde 2 -- l(2)37CcC283 1 -- l(2)37Ccfs1 ethyl methanesulfonate 1 -- l(2)37Cc10 ethyl methanesulfonate gamma ray 0 -- l(2)37Cc11 ethyl methanesulfonate gamma ray 0 -- l(2)37Cc12 ethyl methanesulfonate gamma ray 0 -- l(2)37Cc13 ethyl methanesulfonate gamma ray 0 -- l(2)37Cc14 ethyl methanesulfonate 0 -- l(2)37Cc15 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- l(2)37Cc16 ethyl methanesulfonate 0 -- l(2)37Cc17 ethyl methanesulfonate 0 -- l(2)37Cc18 ethyl methanesulfonate 0 -- l(2)37Cc19 ethyl methanesulfonate 0 -- l(2)37Cc1 ethyl methanesulfonate 0 -- l(2)37Cc21 0 -- l(2)37Cc22 0 -- l(2)37Cc2 ethyl methanesulfonate 0 -- l(2)37Cc3 ethyl methanesulfonate 0 -- l(2)37Cc5 ethyl methanesulfonate 0 -- l(2)37Cc6 ethyl methanesulfonate formaldehyde 0 -- l(2)37Cc7 ethyl methanesulfonate 0 -- l(2)37Cc8 ethyl methanesulfonate 0 -- l(2)37Cc9 ethyl methanesulfonate 0 -- l(2)37Ccts2 ethyl methanesulfonate formaldehyde 0 -- l(2)37Ccts3 0 -- l(2)37CcVA18 0 Yes l(2)37CcZ2-4450 ethyl methanesulfonate 0 -- l(2)37CcZ2-5051 ethyl methanesulfonate 0 --
Alleles Carried on Transgenic Constructs ( 12 )
For All Alleles Carried on Transgenic Constructs Show
Allele of l(2)37Cc Class Mutagen Stocks Known lesion l(2)37CcGD5328 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes l(2)37CcHMS00399 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes l(2)37CcHMS00702 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes l(2)37Cc+t5.3 in vitro construct - genomic fragment 0 Yes l(2)37Cc+t6.6 in vitro construct - genomic fragment 0 Yes l(2)37CcC2 in vitro construct - genomic fragment 0 Yes l(2)37CcC4 in vitro construct - genomic fragment 0 Yes l(2)37CcC5 in vitro construct - genomic fragment 0 Yes l(2)37CcC6 in vitro construct - genomic fragment 0 Yes l(2)37CcNIG.10691R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes l(2)37CcScer\UAS.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes l(2)37CcUbi-p63E.T:Avic\GFP-EGFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)E71 (Wright et al., 1981) Df(2L)Exel6042 (Ryder, 2004.4.26) Df(2L)Exel8040 (Ryder, 2004.4.26) Df(2L)hk-UC2 (Stathakis et al., 1995, Wright, 1996) Df(2L)NST (Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) Df(2L)TW130 (Wright et al., 1981, Gilbert et al., 1984, Black et al., 1987, Stathakis et al., 1995, Wright, 1996) Df(2L)VA17 (Wright et al., 1981, Gilbert et al., 1984, Pentz et al., 1986, Black et al., 1987, Stathakis et al., 1995, Wright, 1996) Df(2L)VA18 (Black et al., 1987, Stathakis et al., 1995) Df(2L)VA21 (Stathakis et al., 1995, Wright, 1996) Df(2L)VA23 (Stathakis et al., 1995)
Not disrupted in	Df(2L)E55 (Stathakis et al., 1995) Df(2L)hk18 (Gilbert et al., 1984, Pentz et al., 1986, Wright, 1996) Df(2L)hk-UC1 (Stathakis et al., 1995, Wright, 1996) Df(2L)OD15 (Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) Df(2L)Sd37 (Stathakis et al., 1995, Wright, 1996) Df(2L)Sd57 (Stathakis et al., 1995, Wright, 1996) Df(2L)Sd77 (Stathakis et al., 1995, Wright, 1996) Df(2L)TE37C-1 (Wright et al., 1981, Wright, 1996) Df(2L)TE37C-7 (Stathakis et al., 1995, Wright, 1996) Df(2L)TW137 (Stathakis et al., 1995) Df(2L)TW203 (Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) Df(2L)VA12 (Wright et al., 1981, Pentz et al., 1986, Stathakis et al., 1995, Wright, 1996) Df(2L)VA13 (Wright et al., 1981, Wright, 1996) Df(2L)VA18 (Pentz et al., 1986) Df(2L)VA19 (Stathakis et al., 1995, Wright, 1996)
Duplicated in	Dp(2;2)M(2)m+ (Wright, 1995.12.1)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5328} NA P{NIG.10691R} NA P{TRiP.HMS00399} NA P{TRiP.HMS00702} NA P{UAS-CG10691.EGFP} NA characterization construct P{pC2} NA P{pC3} NA P{pC4} NA P{pC5} NA P{pC6} NA P{pC7} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{3HPy+}l(2)37CcC283 NA
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cellular response to hypoxia inferred from mutant phenotype (Lee et al., 2008)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Beller et al., 2006) lipid particle inferred from direct assay (Beller et al., 2006, Beller et al., 2006, Cermelli et al., 2006) microtubule associated complex inferred from direct assay (Hughes et al., 2008) mitochondrion inferred from direct assay (Konrad and Marsh, 1991, Alonso et al., 2005)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
instar larval or pupal development non-traceable author statement (Swiss-Prot Project Members, 1992.3.1)
Cellular Component
CV term Evidence References
membrane inferred from electronic annotation with InterPro:IPR000163 (FlyBase Curators et al., 2004-) mitochondrial envelope non-traceable author statement (Konrad and Marsh, 1991) mitochondrion inferred from sequence or structural similarity with Saccharomyces PHB1 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
l(2)37Cc - Ada anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cc - AnxB10 experimental knowledge based (Guruharsha et al., 2011) l(2)37Cc - Arp2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cc - CG10638 experimental knowledge based (Guruharsha et al., 2011) l(2)37Cc - CG1105 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cc - CG12171 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cc - CG12200 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cc - CG13021 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cc - CG13385 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cc - CG1354 experimental knowledge based (Guruharsha et al., 2011) l(2)37Cc - CG13887 experimental knowledge based (Guruharsha et al., 2011) l(2)37Cc - CG14005 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) l(2)37Cc - CG14762 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cc - CG1561 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cc - CG15643 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cc - CG2931 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cc - CG2938 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cc - CG33095 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cc - CG33145 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cc - CG3887 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cc - CG4991 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cc - CG5174 experimental knowledge based (Guruharsha et al., 2011) l(2)37Cc - CG5382 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cc - CG5885 experimental knowledge based (Guruharsha et al., 2011) l(2)37Cc - CG7049 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cc - CG7288 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cc - CG7881 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cc - CG7979 experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) l(2)37Cc - CG8311 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cc - Ccp84Ac anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cc - Cct2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cc - CoIV experimental knowledge based (Guruharsha et al., 2011) l(2)37Cc - HPS1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cc - Men anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cc - Ost48 experimental knowledge based (Guruharsha et al., 2011) l(2)37Cc - PHGPx anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cc - Pdi experimental knowledge based (Guruharsha et al., 2011) l(2)37Cc - Pis anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cc - Pli anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) l(2)37Cc - RhoGEF4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cc - Rpp30 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cc - Snap anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cc - Socs44A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cc - Syb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cc - Tgt anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cc - Tsp29Fb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cc - aur anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cc - l(2)03709 experimental knowledge based (Guruharsha et al., 2011) l(2)37Cc - mRpL19 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cc - mus209 experimental knowledge based (Guruharsha et al., 2011) l(2)37Cc - p130CAS anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) l(2)37Cc - porin experimental knowledge based (Guruharsha et al., 2011)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions l(2)37Cc allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 72039 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0002031 DroID - A comprehensive database of gene and protein interactions. • FBgn0002031 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 49168
Orthologs
OrthoDB Orthologs (57) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6FTWKW Dipteran inclusive ortholog search EOG608NJ1 Insect inclusive ortholog search EOG6FFBXT Arthropod inclusive ortholog search EOG62Z365 Metazoa inclusive ortholog search EOG6JHR8W
Orthologs in Drosophila Species (EOG6FTWKW)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\l(2)37Cc     Drosophila simulans   Dsim\GD21777 Y   Drosophila sechellia   Dsec\GM17028 Y   Drosophila erecta   Dere\GG21649 Y   Drosophila yakuba   Dyak\GE12669 Y   Drosophila ananassae   Dana\GF15209 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA10498 Y   Drosophila persimilis   Dper\GL21128 Y   Drosophila willistoni   Dwil\GK24235 Y   Drosophila virilis   Dvir\GJ17994 Y   Drosophila mojavensis   Dmoj\GI17234 Y   Drosophila grimshawi   Dgri\GH13482 Y
Orthologs in non-Drosophila Dipterans (EOG608NJ1)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL009345   Anopheles gambiae Malaria mosquito  Agam\AGAP009323   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ801571   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ801575
Orthologs in non-Dipteran Insects (EOG6FFBXT)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC408412   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG001595   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17587   Atta cephalotes Leafcutter ant  Acep\ACEP21450   Camponotus floridanus Florida carpenter ant  Cflo\CFLO15092   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14453   Linepithema humile Argentine ant  Lhum\LH16560   Pogonomyrmex barbatus Red harvester ant  Pbar\PB24767   Solenopsis invicta Red fire ant  Sinv\SINV26081   Acyrthosiphon pisum Pea aphid  Apim\ACYPI000080   Bombyx mori Silkmoth  Bmor\BGIBMGA006158   Pediculus humanus Human body louse  Phum\PHUM507380   Tribolium castaneum Red flour beetle  Tcas\TC013727
Orthologs in non-Insect Arthropods (EOG62Z365)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Rhobtb2   Ixodes scapularis Deer tick  Isca\ISCW001788
Orthologs in non-Arthropod Metazoa (EOG6JHR8W)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\phb-2 Y Caenorhabditis elegans Nematode  Cele\phb-1 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004938gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_011671gn Y Danio rerio Zebrafish  Drer\zgc:86841 Y Danio rerio Zebrafish  Drer\phb2 Y Danio rerio Zebrafish  Drer\phb Y Xenopus tropicalis Western clawed frog  Xtro\phb Y Xenopus tropicalis Western clawed frog  Xtro\phb2 Y Gallus gallus Domestic chicken  Ggal\PHB Y Gallus gallus Domestic chicken  Ggal\PHB2 Y Mus musculus House mouse  Mmus\Phb2 Y Mus musculus House mouse  Mmus\Phb Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000030810 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000015823 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000006625 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000021785 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000026193 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000027568 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000040030 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000021699 Y Rattus norvegicus Norway rat  Rnor\RGD1566197 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000028692 Y Rattus norvegicus Norway rat  Rnor\Phb2 Y Homo sapiens Human  Hsap\PHB2 Y Homo sapiens Human  Hsap\PHB Y
Human Orthologs (2)
Gene OMIM HGNC Hsap\PHB2     Hsap\PHB
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD21777 Drosophila sechellia Dsec\GM17028 Drosophila erecta Dere\GG21649 Drosophila yakuba Dyak\GE12669 Drosophila ananassae Dana\GF15209 Drosophila pseudoobscura pseudoobscura Dpse\GA10498 Drosophila persimilis Dper\GL21128 Drosophila willistoni Dwil\GK24235 Drosophila virilis Dvir\GJ17994 Drosophila mojavensis Dmoj\GI17234 Drosophila grimshawi Dgri\GH13482
Stocks & Reagents
Stocks Listed in FlyBase ( 14 )
Bloomington	3395 l(2)37Cc4 pr1/CyO 5389 l(2)37Cc20 pr1/CyO 5390 l(2)37Cc23 or49h/CyO 32912 y1 sc* v1; P{TRiP.HMS00702}attP2 5391 l(2)37Ccts1/CyO, dpov1 pr1 cn1 16326 y1 w1118; PBac{3HPy+}l(2)37CcC283/CyO
Kyoto	107029 l(2)37Cc4 pr1/CyO 108199 l(2)37Cc20 pr1/CyO 108200 l(2)37Cc23 or49h/CyO 108201 l(2)37Ccts1/CyO, dpov1 pr1 cn1
VDRC	v12360 w1118; P{GD5328}v12360 v12358 w1118; P{GD5328}v12358/TM3
	More stocks available...
Genomic Clones ( 2 )
	BACR04C20 BACR48O01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 95 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH12454
Other clones	DPiM_GH12454
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT03926 AT14618 AT17341 AT17843 AT20556 AT22884 AT23171 GH11802 GH14510 GM01842 GM02108 GM02482 GM03028 GM04636 GM09947 GM12114 GM12405 GM18250 GM22113 GM30159 GM32148 LD01347 LD06450 LD12885 LD46012 LP17606 RE03281 RE04539 RE17968 RE28150 RE30653 RE31246 RE34527 RE39551 RE55332 RE67858 RE72506 RE74322 RH49744 RH59480 RH62753 RH72186 SD02144 SD10428 SD12464 SD13232 SD13941
Other clones	78466 124284 147743 165874 bs12h11 bs16f10 bs31a08 bs54b12 bs62b03 CK01.3D.D7 CK01.15C.C1 CK01.73D.F9 CK01.127C.F7 Dmel_dig_016642_0708_2744 Dmel_dig_018614_0598_3319 Dmel_dig_019782_0699_2952 Dmel_neb_003377_0825_3648 Dmel_neb_008898_0925_3266 Dmel_neb_009191_0077_2670 Dmel_neb_011001_0316_2674 EK015609 EK051512 EK058023 EK097816 EK149507 EK184306 EK207630 EK252962 EK270431 FGM227G07 IP10674 IP10774 RM07442 RM07542 RM07642 RM07742 RM07842 RM07942 RM08042 RM08142 RP001009747 RP001016488 RP001039579 RP001052254 UUGC0343 UUGC0417
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0002031 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 49168
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: l(2)37Cc CG10691 (Bayraktaroglu, 2000.4.12)
Additional comments
Other Comments
	Located between coordinates +5.8 and +7.4. (Stathakis et al., 1995) Biochemical characterization of the l(2)37Cc gene product suggest the protein is associated with a mitochondrial membrane. (Konrad and Marsh, 1991) l(2)37Cc has a role in cuticle formation. (Black et al., 1987) Dot matrix analysis demonstrates there is very little sequence homology between Ddc or amd, and l(2)37Cc or CG10561 transcripts, nor is there any relationship between l(2)37Cc or CG10561 transcripts. (Eveleth and Marsh, 1986) Complementation analysis of the 7.6kb PstI fragment demonstrates this fragment carries the Ddc gene alone. (Marsh et al., 1985) Many different complementing heteroallelic genotypes exhibit opaque wings, often incompletely expanded, moderate Minute-like bristles and a lighter tan body color.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057259 NM_165281 RefSeq (Proteins) • NP_476607 NP_724165 DDBJ / EMBL / GenBank • AA694954 AAF53765 AAM52623 AAN11026 AC005440 AC007176 ACZ94298 AI134881 AI531203 AI945443 AI945771 AW940465 AY122111 BE662203 CAA27807 CAA27810 X04227 X04228 Entrez Gene - A searchable database of RefSeq genes. • 49168 UniProtKB/Swiss-Prot • P24156 UniProtKB/TrEMBL • E1JHL5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Prohibitin (IPR000163) Band 7 protein (IPR001107) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH12454
Linkouts
	BioGRID - A database of protein and genetic interactions • 72039 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0002031 DroID - A comprehensive database of gene and protein interactions. • FBgn0002031 DRSC - Results from RNAi screens. • FBgn0002031 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002031 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10691-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0002031 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 49168 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 49168 modMine - Data generated by the modENCODE project. • FBgn0002031
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	Cc (Wright, 1996, McCrady and Tolin, 1994) CG10691 (Beller et al., 2006, Cermelli et al., 2006, Toledano-Katchalski et al., 2007, Lee et al., 2008, Hughes et al., 2008, Ni et al., 2010.12.1, Cammarato et al., 2011) fs(2)HH32   l(2)37Cc (Beller et al., 2006, McCrady and Tolin, 1994, Pilot et al., 2006, Cermelli et al., 2006, Gallach et al., 2010, Lee et al., 2008, Levine et al., 2007, Wright, 1987, Fujiyama-Nakamura et al., 2009, Zhou et al., 2008, Wasbrough et al., 2010, Japanese National Institute of Genetics, 2012.5.21) l (2) 37Cc (Alonso et al., 2005) l(2)Cc (Konrad and Marsh, 1991)
Name Synonym	lethal (2) 37Cc (Cammarato et al., 2011) transcription unit No. 4 (Black et al., 1987)
Secondary FlyBase IDs
	FBgn0032758
References ( 53 )
Generate a list of	All references relating to this gene ( 53 )
List References by type	Research paper  ( 24 ) Supplementary material  ( 9 ) Review  ( 1 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 1 ) FlyBase analysis  ( 3 ) Stock list  ( 1 ) Protein sequence record  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 1 ) Book  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2011 Show research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...