FlyBase Gene Report: Dmel\CG10561

General Information

Symbol

Dmel\CG10561

Species

D. melanogaster

Name

Annotation Symbol

CG10561

Feature Type

protein_coding_gene

FlyBase ID

FBgn0002036

Gene Model Status

Current

Stock Availability

5 publicly available

Gene Summary

Has a non-vital function. (UniProt, P18487)

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

TU37C2, l(2)37Cs, anon-37Cs, Cs

Key Links

Genomic Location

Cytogenetic map

37C1-37C1

Sequence location

2L:19,114,401..19,116,570 [+]

Recombination map

2-54

RefSeq locus

NT_033779 REGION:19114401..19116570

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (3 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables oxidoreductase activity

inferred from electronic annotation with InterPro:IPR002937

(InterPro Project Members, 2004-)

enables polyamine oxidase activity

inferred from biological aspect of ancestor with PANTHER:PTN000077987

(GO Reference Genome Project, 2011-)

Biological Process (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Spencer et al., 1986)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in cytoplasm

inferred from biological aspect of ancestor with PANTHER:PTN000077987

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

CH-NH OXIDOREDUCTASES, OXYGEN AS ACCEPTOR

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

CH-NH OXIDOREDUCTASES, OXYGEN AS ACCEPTOR -: CH-NH oxidoreductases, oxygen as acceptor catalyze an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces oxygen.

Protein Function (UniProtKB)

Has a non-vital function.

(UniProt, P18487)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CG10561 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P18487)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.52

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CG10561-RA

FBtr0081155

NM_057260

2052

504

Additional Transcript Data and Comments

Reported size (kB)

2.0 (northern blot)

(Marsh et al., 1986, Spencer et al., 1986)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

CG10561-PA

FBpp0080699

56.2

504

8.45

P18487

NP_476608

AAF53761

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

504 (aa)

(Tatarenkov et al., 1999)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

P18487

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG10561 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG10561_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

5.15

Transcript Expression

dot blot

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage | male

adult head

(Spencer et al., 1986)

adult thorax

(Spencer et al., 1986)

adult stage | female

adult head

(Spencer et al., 1986)

adult thorax

(Spencer et al., 1986)

adult abdomen

(Spencer et al., 1986)

adult stage

ovary

(Spencer et al., 1986)

testis

(Spencer et al., 1986)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 13 -- 16

organism | faint | ubiquitous

(Fisher et al., 2012)

ventral sensory complex primordium

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Spencer et al., 1986)

third instar larval stage

(Spencer et al., 1986)

adult stage

(Spencer et al., 1986)

Additional Descriptive Data

CG10561 transcripts are detected at very high levels in 1 hr embryos, at high levels in 2 and 8 hr embryos, and at lower levels in 14 hr embryos and in mature larvae. Expression is also detected in adults.

(Spencer et al., 1986)

CG10561 transcripts are detected at low levels in maleand female heads and thoraces, and in female abdomens and ovaries, but at high levels in testes.

(Spencer et al., 1986)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Spencer et al., 1986)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CG10561 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CG10561

View exonic expression by tissue for Dmel\CG10561

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0002036

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35189/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0002036

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0002036

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0002036

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10561

Flygut - An atlas of the Drosophila adult midgut

FBgn0002036

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\CG10561

Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 3 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CG10561

Transgenic constructs containing regulatory region of CG10561

Aberrations (Deficiencies and Duplications) ( 5 )

Inferred from experimentation ( 5 )

Gene disrupted in

Df(2L)Exel6042

(Ryder, 2004.4.26)

Df(2L)Exel8040

(Ryder, 2004.4.26)

Df(2L)TW130

(Black et al., 1987)

Df(2L)VA18

(Black et al., 1987)

Gene not disrupted in

Df(2L)VA17

(Wright, 1996, Black et al., 1987)

Inferred from location ( 11 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

CG10561^f06260

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CG10561^GD7017

viable, with Scer\GAL4^Mef2.PR

CG10561^GD7017

viable, with Scer\GAL4^pnr-MD237

CG10561^GD7017

Sterility

Allele

fertile

CG10561^f06260

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (8)

Hsap\PAOX

7 of 14

Yes

6 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (10)

Rnor\Paox

7 of 14

Yes

6 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (11)

Mmus\Paox

7 of 14

Yes

5 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Yes

Mmus\Ppox

1 of 14

Xenopus tropicalis (Western clawed frog) (14)

Xtro\smox

4 of 13

Yes

Xtro\XB5760632

4 of 13

Yes

Xtro\il21

2 of 13

Yes

2 of 13

2 of 13

1 of 13

1 of 13

Yes

Xtro\kdm1b

1 of 13

Xtro\LOC100495198

1 of 13

Xtro\LOC101734074

1 of 13

Yes

Xtro\maoa

1 of 13

Xtro\mettl3

1 of 13

Xtro\pygo1

1 of 13

Yes

Xtro\slc12a6

1 of 13

Danio rerio (Zebrafish) (11)

Drer\paox

7 of 14

Yes

Drer\zgc:66484

7 of 14

Yes

Drer\smox

6 of 14

Drer\paox1

5 of 14

Drer\il4i1

2 of 14

Yes

Drer\kdm1a

2 of 14

Drer\LOC110440136

2 of 14

Yes

Drer\mao

2 of 14

Drer\si:ch211-127i16.2

2 of 14

Drer\cc2d1b

1 of 14

Drer\ppox

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (6)

Cele\hpo-15

7 of 14

Yes

5 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (9)

Agam\AgaP_AGAP002616

5 of 12

Yes

Agam\AgaP_AGAP007014

5 of 12

Yes

Agam\AgaP_AGAP007015

5 of 12

Yes

Agam\AgaP_AGAP007016

5 of 12

Yes

Agam\AgaP_AGAP007017

5 of 12

Yes

Agam\AgaP_AGAP011206

5 of 12

Yes

Agam\AgaP_AGAP011207

5 of 12

Yes

Agam\AgaP_AGAP003704

1 of 12

Agam\AgaP_AGAP011661

1 of 12

Arabidopsis thaliana (thale-cress) (12)

Atha\PAO5

5 of 13

Yes

Atha\PAO1

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\FMS1

4 of 13

Yes

Scer\HEM14

1 of 13

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\hem14

1 of 12

Yes

Spom\lsd1

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CG10561. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (8)

8 of 13

8 of 13

7 of 13

7 of 13

7 of 13

4 of 13

2 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

CG10561^f06260

ameliorates childhood spinal muscular atrophy

modeled by Smn^73Ao

(Chang et al., 2008)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PAOX; polyamine oxidase

7 of 14

615853

SMOX; spermine oxidase

6 of 14

615854

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Other Interaction Browsers

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Smn

suppressible

CG10561

(Chang et al., 2008)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

61174

DroID - A comprehensive database of gene and protein interactions.

FBgn0002036

MIST (protein-protein) - An integrated Molecular Interaction Database

35189

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-54

Cytogenetic map

37C1-37C1

Sequence location

2L:19,114,401..19,116,570 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

37C1-37C1

Limits computationally determined from genome sequence between P{lacW}l(2)37Db^k16106&P{lacW}Catsup^k05424 and P{lacW}Ddc^k02104

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-54

(FlyBase, 2016)

2-53.6

(Comeron et al., 2012)

2-53.9

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (5)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

18954

w¹¹¹⁸; PBac{WH}CG10561^f06260

NIG-Fly

M2L-2578

y¹ w¹¹¹⁸; CG10561^SK2 P{neoFRT}40A/CyO-Tb

M2L-2579

y¹ w¹¹¹⁸; CG10561^SK7 P{neoFRT}40A/CyO-Tb

2LG-2045

y² VhaAC39-1^cho-1 v¹; P{U6-CG10561.NIG.sgRNA}attP40/CyO

VDRC

v16963

w¹¹¹⁸; P{GD7017}v16963

Genomic Clones (12)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (20)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

GH22841

Other clones

FI03691

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0002036

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0002036

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Located between coordinates -1.7 and +0.2.

(Stathakis et al., 1995)

CG10561 has been cloned and sequenced. The 3' end of the CG10561 gene overlaps with the 3' end of the Ddc gene.

(Eveleth and Marsh, 1987)

Dot matrix analysis demonstrates there is very little sequence homology between Ddc or amd, and l(2)37Cc or CG10561 transcripts, nor is there any relationship between l(2)37Cc or CG10561 transcripts.

(Eveleth and Marsh, 1986)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG10561 anon-37Cb anon-37Cc

(FlyBase, 1996-)

Source for merge of: CG10561 anon-37Cd

(FlyBase, 1996-)

Additional comments

Source for merge of CG10561 anon-37Cb anon-37Cc was sequence comparison ( date:031111 ).

(FlyBase, 1996-)

Source for merge of CG10561 anon-37Cd was sequence comparison ( date:050113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (19)

Reported As

Symbol Synonym

Anon-37Cs

(Katz et al., 2003)

(McCrady and Tolin, 1994)

CG10561

(National Institute of Genetics Fly Stocks, 2022-, Hosono et al., 2015, Sen et al., 2013, Pan and Zhang, 2009, Chang et al., 2008, Katz et al., 2003, McCrady and Tolin, 1994)

(Whitfield and Tatarenkov, 1999.4.12, Black et al., 1987)

ORF1

(Eveleth, 1999.2.24)

ORF2

(Eveleth, 1999.2.24)

ORF3

(Eveleth, 1999.2.24)

TU37C1

TU37C2

(Wright, 1996, Stathakis et al., 1995)

TuC1

(Thor et al., 1999)

anon-37Cb

anon-37Cc

anon-37Cd

anon-37Cs

(FlyBase Curators, 2002-)

(Tatarenkov, 1998.9.13)

l(2)37Cs

(Whitfield and Tatarenkov, 1999.4.12)

Name Synonyms

lethal(2)37Cs

transcription unit 37C2

(Stathakis et al., 1995)

transcription unit No. 2

(Black et al., 1987)

Secondary FlyBase IDs

FBgn0026744
FBgn0026745
FBgn0043051

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 46 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

35189

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P18487

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P18487

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P18487

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0002036

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35189/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0002036

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0002036

FlyMine - An integrated database for Drosophila genomics

FBgn0002036

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG10561

MARRVEL_MODEL - MARRVEL (model organism gene)

35189

Linkouts

BioGRID - A database of protein and genetic interactions.

61174

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0002036

DroID - A comprehensive database of gene and protein interactions.

FBgn0002036

DRSC - Results frm RNAi screens

FBgn0002036

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CG10561_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0002036

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0002036

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10561

Flygut - An atlas of the Drosophila adult midgut

FBgn0002036

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC014317

MIST (protein-protein) - An integrated Molecular Interaction Database

35189

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.

References (46)

The following external sites may use different assemblies or annotations than FlyBase.

5.15

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