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Gene Dmel\dre4

General Information
Symbol	Dmel\dre4	Species	D. melanogaster
Name	dre4	Annotation symbol	CG1828
Feature type	protein_coding_gene	FlyBase ID	FBgn0002183
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	Spt16, dSPT16, l(3)dre4
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	62B7-62B7	Sequence location	3L:1,871,574..1,876,336 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene dre4 is referred to in FlyBase by the symbol Dmel\dre4 (CG1828, FBgn0002183). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: chromatin binding. There is experimental evidence that it is involved in the biological process: regulation of chromatin assembly or disassembly; positive regulation of transcription elongation from RNA polymerase II promoter; neurogenesis. 83 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Domain of unknown function DUF1747, eukaryote; FACT complex subunit Spt16p/Cdc68p; Peptidase M24, structural domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult brain, larval hindgut, larval salivary gland, larval trachea, adult ovary, adult male reproductive system, larval carcass. Gene sequence location is 3L:1871574..1876336.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	l(3)62Bg Locus displays ca 80 times the mutation rate of most of the other loci in the region, and it is relatively more sensitive to γ irradiation than to EMS mutagenesis than other loci (by a factor of six); in addition, none of the alleles is associated with a gross chromosome rearrangement. Hemizygotes are arrested in the first larval instar, where they remain robust and active. One allele temperature sensitive; developmental arrest takes place shortly after shift up in temperature at several stages.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	References Dalton et al., 2010, BMC Genomics 11: 541 Controlled Vocabulary Terms nucleus positive regulation of transcription elongation from RNA polymerase II promoter chromatin binding Sequence features BKN20883 HFA08714
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 62B7-62B7   Limits computationally determined from genome sequence between P{PZ}dlt04276 and P{PZ}slsrL182
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\dre4 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) dre4-RA FBtr0072864  NM_057262   3714   1122 dre4-RB FBtr0072865  NM_167922   3597   1083
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein dre4-PA   FBpp0072743   127.8   1122   6.66     NP_476610   AAF47587 dre4-PB   FBpp0072744   123.6   1083   6.21     NP_728686   AAN11502
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidase M24, structural domain (IPR000994) Domain of unknown function DUF1747, eukaryote (IPR013719) FACT complex subunit Spt16p/Cdc68p (IPR013953)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA263481   AA697111   AA978633   AE014296 AAF47587   AE014296 AAN11502   AB083008 BAC54898   AC004713   AF023269 AAB80935   AF023270 AAB80936   AI512751   AI530918   AI530947   AI531152   AI531475   BE976792   BF491003   BF492212   BF498918   BF505896   BG635513   BT010116 AAQ22585   BT024965   CO179522   CO262570   CO287563   CO291380   CO309237   CO322570   CO332746   CO344999   CZ476816   EC052453   EC053933   EC057509   EC063095   EC067862   EC078154   EC226706   EC227395   EC241859   EC241935   EC242375   EC242376   EC255975   EC256396   EL875357   EL884083   EL884202   EV581493
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IRG6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0002183    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0002183 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0002183 expression level Developmental Stage   Expression Level embryo 00-02hr    8818 embryo 02-04hr    3006 embryo 04-06hr    8966 embryo 06-08hr    6121 embryo 08-10hr    4494 embryo 10-12hr    2053 embryo 12-14hr    1198 embryo 14-16hr    919 embryo 16-18hr    602 embryo 18-20hr    434 embryo 20-22hr    464 embryo 22-24hr    510 larva L1    2074 larva L2    1756 larva L3 12hr old    1404 larva L3 puffstage 1-2    1767 larva L3 puffstage 3-6    2481 larva L3 puffstage 7-9    2643 white prepupae new    2508 white prepupae 12hr    3710 white prepupae 24hr    3545 pupae 2d postWPP    1337 pupae 3d postWPP    642 pupae 4d postWPP    881 adult male 01day    992 adult male 05day    1334 adult male 30day    1283 adult female 01day    3890 adult female 05day    6313 adult female 30day    6128 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (8818) embryo 02-04hr  (3006) embryo 04-06hr  (8966) embryo 06-08hr  (6121) embryo 08-10hr  (4494) embryo 10-12hr  (2053) embryo 12-14hr  (1198) embryo 14-16hr  (919) embryo 16-18hr  (602) embryo 18-20hr  (434) embryo 20-22hr  (464) embryo 22-24hr  (510) larva L1  (2074) larva L2  (1756) larva L3 12hr old  (1404) larva L3 puffstage 1-2  (1767) larva L3 puffstage 3-6  (2481) larva L3 puffstage 7-9  (2643) white prepupae new  (2508) white prepupae 12hr  (3710) white prepupae 24hr  (3545) pupae 2d postWPP  (1337) pupae 3d postWPP  (642) pupae 4d postWPP  (881) adult male 01day  (992) adult male 05day  (1334) adult male 30day  (1283) adult female 01day  (3890) adult female 05day  (6313) adult female 30day  (6128) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (8818) embryo 02-04hr  (3006) embryo 04-06hr  (8966) embryo 06-08hr  (6121) embryo 08-10hr  (4494) embryo 10-12hr  (2053) embryo 12-14hr    1198 embryo 14-16hr    919 embryo 16-18hr    602 embryo 18-20hr    434 embryo 20-22hr    464 embryo 22-24hr    510 larva L1  (2074) larva L2  (1756) larva L3 12hr old  1404 larva L3 puffstage 1-2  (1767) larva L3 puffstage 3-6  (2481) larva L3 puffstage 7-9  (2643) white prepupae new  (2508) white prepupae 12hr  (3710) white prepupae 24hr  (3545) pupae 2d postWPP    1337 pupae 3d postWPP    642 pupae 4d postWPP    881 adult male 01day    992 adult male 05day    1334 adult male 30day    1283 adult female 01day  (3890) adult female 05day  (6313) adult female 30day  (6128) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    8818 embryo 02-04hr    3006 embryo 04-06hr    8966 embryo 06-08hr    6121 embryo 08-10hr    4494 embryo 10-12hr    2053 embryo 12-14hr    1198 embryo 14-16hr    919 embryo 16-18hr    602 embryo 18-20hr    434 embryo 20-22hr    464 embryo 22-24hr    510 larva L1    2074 larva L2    1756 larva L3 12hr old    1404 larva L3 puffstage 1-2    1767 larva L3 puffstage 3-6    2481 larva L3 puffstage 7-9    2643 white prepupae new    2508 white prepupae 12hr    3710 white prepupae 24hr    3545 pupae 2d postWPP    1337 pupae 3d postWPP    642 pupae 4d postWPP    881 adult male 01day    992 adult male 05day    1334 adult male 30day    1283 adult female 01day    3890 adult female 05day    6313 adult female 30day    6128 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    8818 embryo 02-04hr    3006 embryo 04-06hr    8966 embryo 06-08hr    6121 embryo 08-10hr    4494 embryo 10-12hr    2053 embryo 12-14hr    1198 embryo 14-16hr    919 embryo 16-18hr    602 embryo 18-20hr    434 embryo 20-22hr    464 embryo 22-24hr    510 larva L1    2074 larva L2    1756 larva L3 12hr old    1404 larva L3 puffstage 1-2    1767 larva L3 puffstage 3-6    2481 larva L3 puffstage 7-9    2643 white prepupae new    2508 white prepupae 12hr    3710 white prepupae 24hr    3545 pupae 2d postWPP    1337 pupae 3d postWPP    642 pupae 4d postWPP    881 adult male 01day    992 adult male 05day    1334 adult male 30day    1283 adult female 01day    3890 adult female 05day    6313 adult female 30day    6128 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0002183 expression level Developmental Stage   Expression Level embryo 00-02hr    8818 embryo 02-04hr    3006 embryo 04-06hr    8966 embryo 06-08hr    6121 embryo 08-10hr    4494 embryo 10-12hr    2053 embryo 12-14hr    1198 embryo 14-16hr    919 embryo 16-18hr    602 embryo 18-20hr    434 embryo 20-22hr    464 embryo 22-24hr    510 larva L1    2074 larva L2    1756 larva L3 12hr old    1404 larva L3 puffstage 1-2    1767 larva L3 puffstage 3-6    2481 larva L3 puffstage 7-9    2643 white prepupae new    2508 white prepupae 12hr    3710 white prepupae 24hr    3545 pupae 2d postWPP    1337 pupae 3d postWPP    642 pupae 4d postWPP    881 adult male 01day    992 adult male 05day    1334 adult male 30day    1283 adult female 01day    3890 adult female 05day    6313 adult female 30day    6128 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (8818) embryo 02-04hr  (3006) embryo 04-06hr  (8966) embryo 06-08hr  (6121) embryo 08-10hr  (4494) embryo 10-12hr  (2053) embryo 12-14hr  (1198) embryo 14-16hr  (919) embryo 16-18hr  (602) embryo 18-20hr  (434) embryo 20-22hr  (464) embryo 22-24hr  (510) larva L1  (2074) larva L2  (1756) larva L3 12hr old  (1404) larva L3 puffstage 1-2  (1767) larva L3 puffstage 3-6  (2481) larva L3 puffstage 7-9  (2643) white prepupae new  (2508) white prepupae 12hr  (3710) white prepupae 24hr  (3545) pupae 2d postWPP  (1337) pupae 3d postWPP  (642) pupae 4d postWPP  (881) adult male 01day  (992) adult male 05day  (1334) adult male 30day  (1283) adult female 01day  (3890) adult female 05day  (6313) adult female 30day  (6128) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (8818) embryo 02-04hr  (3006) embryo 04-06hr  (8966) embryo 06-08hr  (6121) embryo 08-10hr  (4494) embryo 10-12hr  2053 embryo 12-14hr    1198 embryo 14-16hr    919 embryo 16-18hr    602 embryo 18-20hr    434 embryo 20-22hr    464 embryo 22-24hr    510 larva L1  2074 larva L2  1756 larva L3 12hr old  1404 larva L3 puffstage 1-2  1767 larva L3 puffstage 3-6  (2481) larva L3 puffstage 7-9  (2643) white prepupae new  (2508) white prepupae 12hr  (3710) white prepupae 24hr  (3545) pupae 2d postWPP    1337 pupae 3d postWPP    642 pupae 4d postWPP    881 adult male 01day    992 adult male 05day    1334 adult male 30day    1283 adult female 01day  (3890) adult female 05day  (6313) adult female 30day  (6128) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    8818 embryo 02-04hr    3006 embryo 04-06hr    8966 embryo 06-08hr    6121 embryo 08-10hr    4494 embryo 10-12hr    2053 embryo 12-14hr    1198 embryo 14-16hr    919 embryo 16-18hr    602 embryo 18-20hr    434 embryo 20-22hr    464 embryo 22-24hr    510 larva L1    2074 larva L2    1756 larva L3 12hr old    1404 larva L3 puffstage 1-2    1767 larva L3 puffstage 3-6    2481 larva L3 puffstage 7-9    2643 white prepupae new    2508 white prepupae 12hr    3710 white prepupae 24hr    3545 pupae 2d postWPP    1337 pupae 3d postWPP    642 pupae 4d postWPP    881 adult male 01day    992 adult male 05day    1334 adult male 30day    1283 adult female 01day    3890 adult female 05day    6313 adult female 30day    6128 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    8818 embryo 02-04hr    3006 embryo 04-06hr    8966 embryo 06-08hr    6121 embryo 08-10hr    4494 embryo 10-12hr    2053 embryo 12-14hr    1198 embryo 14-16hr    919 embryo 16-18hr    602 embryo 18-20hr    434 embryo 20-22hr    464 embryo 22-24hr    510 larva L1    2074 larva L2    1756 larva L3 12hr old    1404 larva L3 puffstage 1-2    1767 larva L3 puffstage 3-6    2481 larva L3 puffstage 7-9    2643 white prepupae new    2508 white prepupae 12hr    3710 white prepupae 24hr    3545 pupae 2d postWPP    1337 pupae 3d postWPP    642 pupae 4d postWPP    881 adult male 01day    992 adult male 05day    1334 adult male 30day    1283 adult female 01day    3890 adult female 05day    6313 adult female 30day    6128 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0002183    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0002183 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system. Expression at moderate levels in the following post-embryonic organs or tissues: adult brain, larval hindgut, larval salivary gland, larval trachea, adult ovary, adult male reproductive system, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Heatmap Tissue   Expression Level Larval Central Nervous System no informative data Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland no informative data Larval Trachea no informative data Larval Carcass no informative data Adult Head no informative data Adult Eye no informative data Adult Brain no informative data Adult Thoracic-Abdominal Ganglion no informative data Adult Crop no informative data Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart no informative data Adult VirginFemale Spermatheca no informative data Adult InseminatedFemale Spermatheca no informative data Adult Ovary no informative data Adult Testis no informative data Adult Male Accessory Gland no informative data Adult Carcass no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002183 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1828-RA;CG1828-RB
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 dre4GD4446 lethal | heat sensitive dre4e55ts lethal | larval stage | recessive dre41 dre419 lethal | pupal stage, with Scer\GAL4pnr-MD237 dre4GD4446 lethal | pupal stage | heat sensitive dre4e55ts lethal | recessive | heat sensitive dre4e55ts Other Phenotypes Allele neuroanatomy defective | larval stage, with Scer\GAL41407 dre4GD4446 Phenotype manifest in Allele embryonic/larval neuroblast | larval stage, with Scer\GAL41407 dre4GD4446 ganglion mother cell | larval stage, with Scer\GAL41407 dre4GD4446
Classical Alleles ( 77 )
For All Classical Alleles Show
Allele of dre4 Class Mutagen Stocks Known lesion dre410 ethyl methanesulfonate 0 -- dre411 ethyl methanesulfonate 0 -- dre412 ethyl methanesulfonate 0 -- dre413 ethyl methanesulfonate 0 -- dre414 ethyl methanesulfonate 0 -- dre415 ethyl methanesulfonate 0 -- dre416 ethyl methanesulfonate 0 -- dre417 ethyl methanesulfonate 0 -- dre418 ethyl methanesulfonate 0 -- dre419 gamma ray 0 -- dre41 ethyl methanesulfonate 0 -- dre420 gamma ray 0 -- dre421 gamma ray 0 -- dre422 gamma ray 0 -- dre423 gamma ray 0 -- dre424 gamma ray 0 -- dre425 gamma ray 0 -- dre426 gamma ray 0 -- dre427 gamma ray 0 -- dre428 gamma ray 0 -- dre429 gamma ray 0 -- dre42 ethyl methanesulfonate 0 -- dre430 gamma ray 0 -- dre431 gamma ray 0 -- dre432 gamma ray 0 -- dre433 gamma ray 0 -- dre434 gamma ray 0 -- dre435 gamma ray 0 -- dre436 gamma ray 0 -- dre437 gamma ray 0 -- dre438 gamma ray 0 -- dre439 gamma ray 0 -- dre43 ethyl methanesulfonate 0 -- dre440 gamma ray 0 -- dre441 gamma ray 0 -- dre442 gamma ray 0 -- dre443 gamma ray 0 -- dre444 gamma ray 0 -- dre445 gamma ray 0 -- dre446 gamma ray 0 -- dre447 gamma ray 0 -- dre448 gamma ray 0 -- dre449 gamma ray 0 -- dre44 ethyl methanesulfonate 0 -- dre450 gamma ray 0 -- dre451 gamma ray 0 -- dre452 gamma ray 0 -- dre453 gamma ray 0 -- dre454 gamma ray 0 -- dre455 gamma ray 0 -- dre456 gamma ray 0 -- dre457 gamma ray 0 -- dre458 gamma ray 0 -- dre459 gamma ray 0 -- dre45 ethyl methanesulfonate 0 -- dre460 gamma ray 0 -- dre461 gamma ray 0 -- dre462 gamma ray 0 -- dre463 gamma ray 0 -- dre464 gamma ray 0 -- dre465 gamma ray 0 -- dre466 gamma ray 0 -- dre467 gamma ray 0 -- dre468 gamma ray 0 -- dre469 gamma ray 0 -- dre46 ethyl methanesulfonate 0 -- dre470 gamma ray 0 -- dre471 gamma ray 0 -- dre472 gamma ray 0 -- dre473 gamma ray 0 -- dre474 gamma ray 0 -- dre47 ethyl methanesulfonate 0 -- dre48 ethyl methanesulfonate 0 -- dre49 ethyl methanesulfonate 0 -- dre4d09576 P-element activity 0 -- dre4e55ts ethyl methanesulfonate 0 -- dre4unspecified 0 --
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of dre4 Class Mutagen Stocks Known lesion dre4GD4446 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dre4GL00017 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dre4HMS01332 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dre4KK100787 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dre4Hsp83.PN in vitro construct - regulatory fusion 0 Yes dre4Hsp83.T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Aprt-1 (Wang et al., 1994) Df(3L)Aprt-3 (Wang et al., 1994) Df(3L)Aprt-9 (Wang et al., 1994) Df(3L)Aprt-10 (Wang et al., 1994) Df(3L)Aprt-12 (Wang et al., 1994) Df(3L)Aprt-13 (Wang et al., 1994) Df(3L)Aprt-14 (Wang et al., 1994) Df(3L)Aprt-15 (Wang et al., 1994) Df(3L)Aprt-16 (Wang et al., 1994) Df(3L)Aprt-18 (Machado and Andrew, 2000, Wang et al., 1994) Df(3L)Aprt-19 (Wang et al., 1994) Df(3L)Aprt-21 (Shimojima et al., 2003) Df(3L)Aprt-24 (Machado and Andrew, 2000, Wang et al., 1994) Df(3L)Aprt-26 (Wang et al., 1994) Df(3L)Aprt-27 (Wang et al., 1994) Df(3L)Aprt-29 (Wang et al., 1994) Df(3L)Aprt-31 (Wang et al., 1994) Df(3L)Aprt-32 (Wang et al., 1994) Df(3L)Aprt-36 (Wang et al., 1994) Df(3L)Aprt-42 (Wang et al., 1994) Df(3L)Aprt-46 (Wang et al., 1994) Df(3L)Aprt-47 (Wang et al., 1994) Df(3L)Aprt-48 (Wang et al., 1994) Df(3L)Aprt-53 (Wang et al., 1994) Df(3L)Aprt-54 (Wang et al., 1994) Df(3L)Aprt-56 (Wang et al., 1994) Df(3L)Aprt-61 (Wang et al., 1994) Df(3L)Aprt-65 (Wang et al., 1994) Df(3L)Aprt-66 (Wang et al., 1994) Df(3L)Aprt-71 (Wang et al., 1994) Df(3L)Aprt-72 (Wang et al., 1994) Df(3L)Aprt-73 (Wang et al., 1994) Df(3L)Aprt-74 (Wang et al., 1994) Df(3L)Aprt-77 (Wang et al., 1994) Df(3L)Aprt-79 (Wang et al., 1994) Df(3L)Aprt-84 (Wang et al., 1994) Df(3L)Aprt-87 (Wang et al., 1994) Df(3L)Aprt-88 (Wang et al., 1994) Df(3L)Aprt-89 (Wang et al., 1994) Df(3L)Aprt-90 (Wang et al., 1994) Df(3L)Aprt-91 (Wang et al., 1994) Df(3L)Aprt-92 (Wang et al., 1994) Df(3L)Aprt-93 (Wang et al., 1994) Df(3L)Aprt-94 (Wang et al., 1994) Df(3L)Aprt-95 (Wang et al., 1994) Df(3L)Aprt-96 (Wang et al., 1994) Df(3L)Aprt-97 (Wang et al., 1994) Df(3L)Aprt-98 (Wang et al., 1994) Df(3L)Aprt-99 (Wang et al., 1994) Df(3L)Aprt-100 (Wang et al., 1994) Df(3L)Aprt-101 (Wang et al., 1994) Df(3L)Aprt-102 (Wang et al., 1994) Df(3L)Aprt-103 (Wang et al., 1994) Df(3L)Aprt-104 (Wang et al., 1994) Df(3L)Aprt-105 (Wang et al., 1994) Df(3L)Aprt-106 (Wang et al., 1994) Df(3L)Aprt-107 (Wang et al., 1994) Df(3L)Aprt-108 (Wang et al., 1994) Df(3L)Aprt-109 (Wang et al., 1994) Df(3L)Aprt-110 (Wang et al., 1994) Df(3L)Aprt-111 (Wang et al., 1994) Df(3L)Aprt-112 (Wang et al., 1994) Df(3L)Aprt-113 (Wang et al., 1994) Df(3L)Aprt-115 (Wang et al., 1994) Df(3L)Aprt-116 (Wang et al., 1994) Df(3L)Aprt-117 (Wang et al., 1994) Df(3L)Aprt-118 (Wang et al., 1994) Df(3L)Aprt-119 (Wang et al., 1994) Df(3L)Aprt-120 (Wang et al., 1994) Df(3L)Aprt-121 (Wang et al., 1994) Df(3L)Aprt-122 (Wang et al., 1994) Df(3L)Aprt-124 (Wang et al., 1994) Df(3L)Aprt-125 (Wang et al., 1994) Df(3L)Aprt-126 (Machado and Andrew, 2000, Wang et al., 1994) Df(3L)Aprt-127 (Wang et al., 1994) Df(3L)Aprt-128 (Wang et al., 1994) Df(3L)Aprt-129 (Wang et al., 1994) Df(3L)Aprt-130 (Wang et al., 1994) Df(3L)Aprt-132 (Wang et al., 1994) Df(3L)Aprt-133 (Wang et al., 1994) Df(3L)Aprt-134 (Wang et al., 1994) Df(3L)Aprt-135 (Wang et al., 1994) Df(3L)Aprt-136 (Wang et al., 1994) Df(3L)Aprt-137 (Wang et al., 1994) Df(3L)Aprt-138 (Wang et al., 1994) Df(3L)Aprt-139 (Wang et al., 1994) Df(3L)Aprt-140 (Wang et al., 1994) Df(3L)Aprt-141 (Wang et al., 1994) Df(3L)Aprt-143 (Machado and Andrew, 2000, Wang et al., 1994) Df(3L)Aprt-144 (Wang et al., 1994) Df(3L)Aprt-145 (Wang et al., 1994) Df(3L)Aprt-146 (Wang et al., 1994) Df(3L)Aprt-147 (Wang et al., 1994) Df(3L)Aprt-148 (Wang et al., 1994) Df(3L)Aprt-151 (Wang et al., 1994) Df(3L)Aprt-152 (Wang et al., 1994) Df(3L)Aprt-153 (Wang et al., 1994) Df(3L)Aprt-154 (Wang et al., 1994) Df(3L)Aprt-156 (Wang et al., 1994) Df(3L)Aprt-157 (Wang et al., 1994) Df(3L)Aprt-158 (Wang et al., 1994) Df(3L)Aprt-159 (Wang et al., 1994) Df(3L)Aprt-160 (Wang et al., 1994) Df(3L)Aprt-161 (Wang et al., 1994) Df(3L)Aprt-162 (Wang et al., 1994) Df(3L)Aprt-163 (Wang et al., 1994) Df(3L)Aprt-164 (Wang et al., 1994) Df(3L)Aprt-165 (Wang et al., 1994) Df(3L)Aprt-166 (Wang et al., 1994) Df(3L)Aprt-167 (Wang et al., 1994) Df(3L)Aprt-168 (Wang et al., 1994) Df(3L)Aprt-169 (Wang et al., 1994) Df(3L)Aprt-170 (Wang et al., 1994) Df(3L)Aprt-171 (Wang et al., 1994) Df(3L)Aprt-173 (Wang et al., 1994) Df(3L)Aprt-174 (Wang et al., 1994) Df(3L)Aprt-175 (Wang et al., 1994) Df(3L)Aprt-176 (Wang et al., 1994) Df(3L)Aprt-177 (Wang et al., 1994) Df(3L)Aprt-178 (Wang et al., 1994) Df(3L)Aprt-179 (Wang et al., 1994) Df(3L)Aprt-180 (Wang et al., 1994) Df(3L)Aprt-181 (Wang et al., 1994) Df(3L)Aprt-182 (Wang et al., 1994) Df(3L)Aprt-183 (Wang et al., 1994) Df(3L)Aprt-184 (Wang et al., 1994) Df(3L)Aprt-186 (Wang et al., 1994) Df(3L)Aprt-187 (Wang et al., 1994) Df(3L)Aprt-188 (Wang et al., 1994) Df(3L)Aprt-189 (Wang et al., 1994) Df(3L)Aprt-190 (Wang et al., 1994) Df(3L)Aprt-191 (Wang et al., 1994) Df(3L)Aprt-192 (Wang et al., 1994) Df(3L)Aprt-193 (Wang et al., 1994) Df(3L)Aprt-194 (Wang et al., 1994) Df(3L)Aprt-195 (Wang et al., 1994) Df(3L)Aprt-196 (Wang et al., 1994) Df(3L)Aprt-199 (Wang et al., 1994) Df(3L)Aprt-201 (Wang et al., 1994) Df(3L)R-E (Sliter and Gilbert, 1992) Ts(2Rt;3Rt)Aprt-185 (Wang et al., 1994)
Not disrupted in	Df(3L)Aprt-21 (Wang et al., 1994) Df(3L)Aprt-57 (Wang et al., 1994) Df(3L)Aprt-114 (Wang et al., 1994) Df(3L)Aprt-123 (Machado and Andrew, 2000, Wang et al., 1994) Df(3L)Aprt-131 (Wang et al., 1994) Df(3L)Aprt-142 (Wang et al., 1994) Df(3L)Aprt-149 (Wang et al., 1994) Df(3L)Aprt-150 (Wang et al., 1994) Df(3L)Aprt-172 (Wang et al., 1994) Df(3L)Aprt-198 (Wang et al., 1994)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4446} NA P{KK100787} NA P{TRiP.GL00017} NA P{TRiP.HMS01332} NA heat-shock construct P{Act5C-EGFP,Hsp83-spt16} NA P{Hsp83-spt16.His} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}EY01604 NA P{XP}dre4d09576 NA
Gene Ontology: Function, Process & Cellular Component ( 8 unique terms )
Terms Based on Experimental Evidence ( 6 terms )
Molecular Function
CV term Evidence References
chromatin binding inferred from direct assay (Petruk et al., 2006)
Biological Process
CV term Evidence References
neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) positive regulation of transcription elongation from RNA polymerase II promoter inferred from mutant phenotype (Petruk et al., 2006) regulation of chromatin assembly or disassembly inferred from mutant phenotype (Shimojima et al., 2003)
Cellular Component
CV term Evidence References
FACT complex inferred from direct assay (Tsunaka et al., 2009) nucleus inferred from direct assay (Petruk et al., 2006)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
DNA binding inferred from sequence or structural similarity with EMBL:AB004794 (FlyBase, 1992-)
Biological Process
CV term Evidence References
DNA unwinding involved in replication inferred from sequence or structural similarity with EMBL:AB004794 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
FACT complex traceable author statement (Lehmann, 2004)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions dre4 allele Gene References unspecified Trl (Shimojima et al., 2003) Ubx (Shimojima et al., 2003)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 63776 DroID - A comprehensive database of gene and protein interactions. • FBgn0002183 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38248
Orthologs
Genome-wide drosophilid orthologs	Dana\GF24952 Dere\GG14551 Dgri\GH15037 Dmoj\GI16689 Dper\GL24818 Dpse\GA23520 Dsec\GM14159 Dsim\GD13429 Dvir\GJ12941 Dwil\GK10599 Dyak\GE20905
Curated drosophilid orthologs	Dpse\GA14872
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL011876-PA Aedes aegypti (mosquito) AGAP006817-PA Anopheles gambiae (mosquito) XP_624006.2 Apis mellifera (honey bee) XP_001943501.1 Acyrthosiphon pisum (pea aphid) At4g10710.1 Arabidopsis thaliana (wall cress) 19138 Batrachochytrium dendrobatidis (chytrid fungus) 130325 Branchiostoma floridae (lancelet) BGIBMGA002779-PA Bombyx mori (silk worm) ENSBTAP00000027214 Bos taurus (bovine) CAL0005222 Candida albicans (a form of yeast) CBP29783 Caenorhabditis briggsae (nematode) CE17113 Caenorhabditis elegans (worm) ENSCAFP00000008366 Canis familiaris (dog) CAGL0C03047g Candida glabrata (haploid yeast) Chro.70222 Cryptosporidium hominis (obligate parasite) ENSCINP00000006443 Ciona intestinalis (sea squirt) JA04949 Caenorhabditis japonica (nematode) CMS358C Cyanidioschyzon merolae (red alga) cn03499 Cryptococcus neoformans (yeast-like fungus) cgd7_1930 Cryptosporidium parvum (protozoan parasite) CPIJ014416 Culex pipens (mosquito) ENSCPOP00000002306 Cavia porcellus (guinea pig) 133193 Chlamidomonas reinhardtii (green alga) RP40988 Caenorhabditis remanei (nematode) ENSCSAVP00000019210 Ciona savignyi (sedentary tunicate) 155000 Capitella spl (polychaete worm) DDB0231753 Dictyostelium discoideum (amoeba) DEHA2B03718g Debaryomyces Hansenii (yeast) 220868 Daphnia pulex (daphnia) ENSECAP00000019387 Equus caballus (horse) XP_652208 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000024986 Gymnopilus aculeatus (mushroom) GL50803_17430 Giardia lamblia (flagellated protozoan) 193835 Hypsipyla robusta (cedar shoot borer) ENSP00000216297 Homo sapiens (human) ISCW004234-PA Ixodes scapularis (deer tick) KLLA0F09889g Kluyveromyces lactis (yeast) 124718 Lottia gigantea (owl limpet) LmjF29.0020 Leishmania major (virus) 24618 Monocosta brevicollis (choanoflagellate) ENSMODP00000008120 Monodelphis domestica (gray opossum) ENSMMUP00000019664 Macaca mulatta (rhesus monkey) ENSMUSP00000042283 Mus musculus (house mouse) 247576 Nematostella vectensis (starlet anemone) XP_001606750.1 Nasonia vitripennis (wasp) ENSOANP00000018650 Ornithorynchus anatinus (platypus) ENSORLP00000011001 Oryzias latipes (japanese killifish) LOC_Os04g25550.1 Oryza sativa (asian rice) 20592 Ostreococcus tauri (green alga) PFE0870w Plasmodium falciparum (protozoal parasite) PHUM005312-PA Pediculus humanus (human body louse) PP27116 Pristionchus pacificus (nematode) 152713 Physcomitrella patens (moss) ENSPPYP00000006363 Pongo pygmaeus (orangutan) 74054 Phytophthora ramorum (sudden oak death pathogen) 139583 Phytophthora sojae (root rot pathogen) 811158 Populus trichocarpa (black cottonwood) ENSPTRP00000010390 Pan troglodytes (chimpanzee) PVX_080380 Plasmodium vivax (protozoal parasite) ENSRNOP00000016288 Rattus norvegicus (norway rat) 4867091 Sorghum bicolor (sorghum) YGL207W Saccharomyces cerevisiae (budding yeast) Smp_088280 Schistosoma mansoni (trematode parasite) SPBP8B7.19 Schizosaccharomyces pombe (fission yeast) XP_001203176.1 Strongylocentrotus purpuratus (purple sea urchin) 18255 Trichoplax adhaerens (metazoa) TA07800 Theileria annulata (apicomplexan parasite) XP_972477.1 Tribolium castaneum (red flour beetle) Tc00.1047053509761.10 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000006289 Tetraodon nigroviridis (green spotted pufferfish) TP04_0311 Theileria parva (parasitic protozoan) 28217 Thalassiosira pseudonana (marine diatom) ENSTRUP00000004506 Takifugu rubripes (pufferfish Takifugu) 3694.m00119 Tetrahymena thermophila (ciliate protozoa) 87363.m00173 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000037495 Xenopus tropicalis (frog) YALI0D14652g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV11253 LH20591 ISCW004234 FBgn0240066 FBgn0238194 FBgn0212614 FBgn0200175 FBgn0185142 FBgn0169085 JGI_V11_220868 FBgn0244921 FBgn0162406 FBgn0139437 FBgn0122512 FBgn0106809 FBgn0101944 CPIJ014416 BGIBMGA002779 ACYPI000295 GB13130 AGAP006817 AAEL015182 AAEL011876 PB21833 PHUM054470 GLEAN_14294
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	35149 y1 sc* v1; P{TRiP.GL00017}attP2 34344 y1 sc* v1; P{TRiP.HMS01332}attP2
VDRC	v106049 P{KK100787}VIE-260B v10916 w1118; P{GD4446}v10916
Genomic Clones ( 2 )
	BACR10D15 BACR16A03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 40 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT29108 IP15245
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT08135 AT13334 AT27651 GM09102 LD06538 LD32153 LD44749 SD01691 SD01746 SD02072 SD02532 SD12946
Other clones	62685 158191 164598 174808 214213.23 214213.24 277478 bs55h08 CK01.29D.F12 CK01.76B.E3 CK01.82D.H6 CK01.101D.D3 Dmel_dig_001091_0667_2042 EC052453 EC053933 EK059618 EK066163 EK078214 EK085814 EK188415 EK260810 EK304427 EP21117 IP15345 IP15445 IP15545
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0002183 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38248
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: dre4 CG1828 (Deng, 1999.11)
Source for database merge of
Additional comments
Other Comments
	The FACT complex (FAcilitates Chromatin Transcription) containing dre4 and Ssrp has a crucial role in the modulation of chromatin structure for the regulation of gene expression. (Shimojima et al., 2003) Recessive lethal mutations in this complementation group were identified by failure to complement the recessive lethality of Df(3L)R-R2. This locus is disproportionately mutable: 18 ethyl methanesulfonate and 56 γ ray alleles were isolated. (Sliter et al., 1989) Locus displays ca 80 times the mutation rate of most of the other loci in the region and it is relatively more sensitive to γ irradiation than to EMS mutagenesis than other loci (by a factor of six); in addition, none of the alleles is associated with a gross chromosome rearrangement. Hemizygotes are arrested in the first larval instar, where they remain robust and active. One allele temperature-sensitive; developmental arrest takes place shortly after shift up in temperature at several stages.
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057262 NM_167922 RefSeq (Proteins) • NP_476610 NP_728686 DDBJ / EMBL / GenBank • AAB80935 AAB80936 AAF47587 AAF47587.1 AAF47587.2 AAN11502 AAN11502.1 AAN11502.2 AAQ22585 AB083008 AC004713 AF023269 AF023270 BAC54898 BF492212 BT010116 CZ476816 Entrez Gene - A searchable database of RefSeq genes. • 38248 UniProtKB/TrEMBL • Q8IRG6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peptidase M24, structural domain (IPR000994) Domain of unknown function DUF1747, eukaryote (IPR013719) FACT complex subunit Spt16p/Cdc68p (IPR013953)
Linkouts
	BioGRID - A database of protein and genetic interactions • 63776 DroID - A comprehensive database of gene and protein interactions. • FBgn0002183 DRSC - Results from RNAi screens. • FBgn0002183 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002183 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG1828-RA;CG1828-RB FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0002183 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38248 InParanoid A subset of ortholog calls from InParanoid. • AAEL011876-PA Aedes aegypti (mosquito) AGAP006817-PA Anopheles gambiae (mosquito) XP_624006.2 Apis mellifera (honey bee) XP_001943501.1 Acyrthosiphon pisum (pea aphid) At4g10710.1 Arabidopsis thaliana (wall cress) 19138 Batrachochytrium dendrobatidis (chytrid fungus) 130325 Branchiostoma floridae (lancelet) BGIBMGA002779-PA Bombyx mori (silk worm) ENSBTAP00000027214 Bos taurus (bovine) CAL0005222 Candida albicans (a form of yeast) CBP29783 Caenorhabditis briggsae (nematode) CE17113 Caenorhabditis elegans (worm) ENSCAFP00000008366 Canis familiaris (dog) CAGL0C03047g Candida glabrata (haploid yeast) Chro.70222 Cryptosporidium hominis (obligate parasite) ENSCINP00000006443 Ciona intestinalis (sea squirt) JA04949 Caenorhabditis japonica (nematode) CMS358C Cyanidioschyzon merolae (red alga) cn03499 Cryptococcus neoformans (yeast-like fungus) cgd7_1930 Cryptosporidium parvum (protozoan parasite) CPIJ014416 Culex pipens (mosquito) ENSCPOP00000002306 Cavia porcellus (guinea pig) 133193 Chlamidomonas reinhardtii (green alga) RP40988 Caenorhabditis remanei (nematode) ENSCSAVP00000019210 Ciona savignyi (sedentary tunicate) 155000 Capitella spl (polychaete worm) DDB0231753 Dictyostelium discoideum (amoeba) DEHA2B03718g Debaryomyces Hansenii (yeast) 220868 Daphnia pulex (daphnia) ENSECAP00000019387 Equus caballus (horse) XP_652208 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000024986 Gymnopilus aculeatus (mushroom) GL50803_17430 Giardia lamblia (flagellated protozoan) 193835 Hypsipyla robusta (cedar shoot borer) ENSP00000216297 Homo sapiens (human) ISCW004234-PA Ixodes scapularis (deer tick) KLLA0F09889g Kluyveromyces lactis (yeast) 124718 Lottia gigantea (owl limpet) LmjF29.0020 Leishmania major (virus) 24618 Monocosta brevicollis (choanoflagellate) ENSMODP00000008120 Monodelphis domestica (gray opossum) ENSMMUP00000019664 Macaca mulatta (rhesus monkey) ENSMUSP00000042283 Mus musculus (house mouse) 247576 Nematostella vectensis (starlet anemone) XP_001606750.1 Nasonia vitripennis (wasp) ENSOANP00000018650 Ornithorynchus anatinus (platypus) ENSORLP00000011001 Oryzias latipes (japanese killifish) LOC_Os04g25550.1 Oryza sativa (asian rice) 20592 Ostreococcus tauri (green alga) PFE0870w Plasmodium falciparum (protozoal parasite) PHUM005312-PA Pediculus humanus (human body louse) PP27116 Pristionchus pacificus (nematode) 152713 Physcomitrella patens (moss) ENSPPYP00000006363 Pongo pygmaeus (orangutan) 74054 Phytophthora ramorum (sudden oak death pathogen) 139583 Phytophthora sojae (root rot pathogen) 811158 Populus trichocarpa (black cottonwood) ENSPTRP00000010390 Pan troglodytes (chimpanzee) PVX_080380 Plasmodium vivax (protozoal parasite) ENSRNOP00000016288 Rattus norvegicus (norway rat) 4867091 Sorghum bicolor (sorghum) YGL207W Saccharomyces cerevisiae (budding yeast) Smp_088280 Schistosoma mansoni (trematode parasite) SPBP8B7.19 Schizosaccharomyces pombe (fission yeast) XP_001203176.1 Strongylocentrotus purpuratus (purple sea urchin) 18255 Trichoplax adhaerens (metazoa) TA07800 Theileria annulata (apicomplexan parasite) XP_972477.1 Tribolium castaneum (red flour beetle) Tc00.1047053509761.10 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000006289 Tetraodon nigroviridis (green spotted pufferfish) TP04_0311 Theileria parva (parasitic protozoan) 28217 Thalassiosira pseudonana (marine diatom) ENSTRUP00000004506 Takifugu rubripes (pufferfish Takifugu) 3694.m00119 Tetrahymena thermophila (ciliate protozoa) 87363.m00173 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000037495 Xenopus tropicalis (frog) YALI0D14652g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/fact.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38248 modMine - Data generated by the modENCODE project. • FBgn0002183 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV11253 LH20591 ISCW004234 FBgn0240066 FBgn0238194 FBgn0212614 FBgn0200175 FBgn0185142 FBgn0169085 JGI_V11_220868 FBgn0244921 FBgn0162406 FBgn0139437 FBgn0122512 FBgn0106809 FBgn0101944 CPIJ014416 BGIBMGA002779 ACYPI000295 GB13130 AGAP006817 AAEL015182 AAEL011876 PB21833 PHUM054470 GLEAN_14294
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	CG1828 (Keleman et al., 2009.8.5, Ni et al., 2010.12.1, Ni et al., 2011.7.19) dre4 (Wasbrough et al., 2010, Brooks et al., 2011, Dalton et al., 2010) DRE4/dSPT16 (Saurin et al., 2001) dSPT16 (Lehmann, 2004, Shimojima et al., 2003, Tsunaka et al., 2009) dspt16 (Shimojima, 2002.3.28) dSpt16 (Yokoyama et al., 2007) l(3)62Bg (Lindsley and Zimm, 1992, ) l(3)dre4 (Sliter et al., 1989, Lindsley and Zimm, 1992, ) Spt16 (Polo, 2006, Workman and Abmayr, 2004, Saunders et al., 2003, Kwon et al., 2010) spt16 (Shimojima et al., 2003, Petruk et al., 2006, Petruk et al., 2006, Nakayama et al., 2007)
Name Synonym	dre4   lethal(3)62Bg   supressor of Ty element 16 (Shimojima, 2002.3.28)
Secondary FlyBase IDs
	FBgn0002182
References ( 39 )
Generate a list of	All references relating to this gene ( 39 )
List References by type	Research paper  ( 17 ) Supplementary material  ( 5 ) Review  ( 3 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 1 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 1 ) Book  ( 1 ) Curated genome annotation  ( 1 ) Computer file  ( 3 )
Recent research papers ( 3 )
	Brooks et al., 2011, Genome Res. 21(2): 193--202 Conservation of an RNA regulatory map between Drosophila and mammals. [FBrf0213079] Dalton et al., 2010, BMC Genomics 11: 541 Dynamic, mating-induced gene expression changes in female head and brain tissues of Drosophila melanogaster. [FBrf0212122] Kwon et al., 2010, Genes Dev. 24(19): 2133--2145 Heterochromatin protein 1 (HP1) connects the FACT histone chaperone complex to the phosphorylated CTD of RNA polymerase II. [FBrf0212000] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...