FlyBase Gene Report: Dmel\sas

General Information

Symbol

Dmel\sas

Species

D. melanogaster

Name

stranded at second

Annotation Symbol

CG2507

Feature Type

protein_coding_gene

FlyBase ID

FBgn0002306

Gene Model Status

Current

Stock Availability

14 publicly available

Gene Summary

stranded at second (sas) encodes a single-pass transmembrane protein that localizes to the apical cell surface in polarized epithelia, such as the embryonic/larval salivary gland (SG). Overexpression of sas in the developing SG leads to all membrane domains taking on apical membrane character, with the exception of the region where septate junctions form. [Date last reviewed: 2018-09-13] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
UniProtKB
Red Book
Interactive Fly

Also Known As

rfd, l(3)84Cd

Key Links

Genomic Location

Cytogenetic map

84C8-84D1

Sequence location

3R:7,162,808..7,183,702 [+]

Recombination map

3-48

RefSeq locus

NT_033777 REGION:7162808..7183702

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables heparin binding

inferred from biological aspect of ancestor with PANTHER:PTN000142748

(assigned by GO_Central )

(Gaudet et al., 2011)

enables integrin binding

inferred from biological aspect of ancestor with PANTHER:PTN000142748

(assigned by GO_Central )

(Gaudet et al., 2011)

enables signaling receptor activity

non-traceable author statement

(assigned by UniProt )

(Schonbaum et al., 1992)

Biological Process (5 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in axon guidance

inferred from mutant phenotype

(Lee et al., 2013)

involved_in instar larval development

inferred from mutant phenotype

(assigned by UniProt )

(Schonbaum et al., 1992)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in cell adhesion

inferred from biological aspect of ancestor with PANTHER:PTN000142748

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in negative regulation of cell death

inferred from biological aspect of ancestor with PANTHER:PTN000142748

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in signal transduction

inferred from biological aspect of ancestor with PANTHER:PTN000142748

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in apical plasma membrane

inferred from direct assay

(Firmino et al., 2013)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

located_in apical plasma membrane

non-traceable author statement

(Bachmann et al., 2001)

is_active_in extracellular matrix

inferred from biological aspect of ancestor with PANTHER:PTN000142748

(assigned by GO_Central )

(Gaudet et al., 2011)

located_in integral component of plasma membrane

non-traceable author statement

(assigned by UniProt )

(Schonbaum et al., 1992)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Protein Function (UniProtKB)

Vital for larval development (PubMed:1339334). During salivary tube elongation, possibly modulates cellular adhesion between the apical surface and apical extracellular matrix, and acts as an apical membrane determinant that functions in apical membrane expansion independently of crb and Cad99C (PubMed:24718992).

(UniProt, Q04164)

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

sas: stranded-at-second (D. R. Cavener)

Homozygous lethal; homozygotes die at the first to second instar molt or at second instar. Larvae do not grow and exhibit a segmentally repeated pattern of tanned spots on the ventral cuticle between the fourth and fifth row of setae and sometimes between the first and second row of setae. Trachae are convoluted.

Summary (Interactive Fly)

Sas and the receptor-type tyrosine phosphatase PTP10D function as the cell-surface ligand-receptor system that drives tumour-suppressive cell competition - trans-activation of Sas-PTP10D signalling in loser cells restrains EGFR signalling cell elimination and thereby enables elevated JNK signalling in loser cells, triggering cell elimination - expression of Sas in neurons and glia and Ptp10D expressed on longitudinal axons are required to prevent axons from abnormally crossing the midline

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\sas for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure New Section

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q04164)

If you don't see the viewer to the right, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.47

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 6.02

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

sas-RA

FBtr0081571

NM_057263

5115

1348

sas-RB

FBtr0081570

NM_169177

5916

1693

sas-RC

FBtr0334884

NM_001275407

4763

1348

sas-RD

FBtr0334885

NM_001275408

6236

1693

Additional Transcript Data and Comments

Reported size (kB)

5.9, 4.9, 4.0 (northern blot)

(Schonbaum et al., 1992)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

sas-PA

FBpp0081090

147.3

1348

4.36

NP_476611

AAN13346

sas-PB

FBpp0081089

185.3

1693

4.64

NP_731141

AAF54052

sas-PC

FBpp0306905

147.3

1348

4.36

NP_001262336

AGB95719

sas-PD

FBpp0306906

185.3

1693

4.64

NP_001262337

AGB95720

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1693 aa isoforms: sas-PB, sas-PD

1348 aa isoforms: sas-PA, sas-PC

Additional Polypeptide Data and Comments

Reported size (kDa)

1348 (aa)

(Schonbaum et al., 1992)

Comments

External Data

Domain

The extracellular domain is sufficent for conferring apical characteristics on the salivary gland membrane.

(UniProt, Q04164)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\sas using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

sas_1
sas_2

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

dissected tissue

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

epidermis

(Schonbaum et al., 1992)

imaginal disc

(Schonbaum et al., 1992)

third instar larval stage

imaginal disc

(Schonbaum et al., 1992)

expression microarray

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult fat body

Comment: cyclical, peak ZT5-8

(Xu et al., 2011)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 12 -- 16

epidermis

(Schonbaum et al., 1992)

embryonic/larval foregut

(Schonbaum et al., 1992)

embryonic/larval hindgut

(Schonbaum et al., 1992)

embryonic stage 15 -- 16

tracheal section

(Schonbaum et al., 1992)

embryonic/larval esophagus

(Schonbaum et al., 1992)

embryonic/larval proventriculus

(Schonbaum et al., 1992)

embryonic/larval pharynx

(Schonbaum et al., 1992)

third instar larval stage

imaginal disc

(Schonbaum et al., 1992)

adult stage

reproductive system

(Schonbaum et al., 1992)

mouthpart

(Schonbaum et al., 1992)

eye

(Schonbaum et al., 1992)

leg

(Schonbaum et al., 1992)

wing

(Schonbaum et al., 1992)

Additional Descriptive Data

Expressed cyclically in the adult fat body.

(Xu et al., 2011)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16

intersegmental nerve root

(Lee et al., 2013)

segmental nerve root

(Lee et al., 2013)

embryonic/larval central nervous system | faint | restricted

(Lee et al., 2013)

embryonic/larval tracheal dorsal trunk

(Lee et al., 2013)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 13

tracheal pit

• apical plasma membrane

(Klebes and Knust, 2000)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in apical plasma membrane

inferred from direct assay

(Firmino et al., 2013)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\sas in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\sas

View exonic expression by tissue for Dmel\sas

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0002306

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40861/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0002306

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0002306

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0002306

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG2507

Flygut - An atlas of the Drosophila adult midgut

FBgn0002306

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 24 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 13 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of sas

Transgenic constructs containing regulatory region of sas

Aberrations (Deficiencies and Duplications) ( 19 )

Inferred from experimentation ( 19 )

Gene disrupted in

Df(3R)Antp1

(Lewis et al., 1980)

Df(3R)Antp17

(Lewis et al., 1980)

Df(3R)Antp-A41

(Cavener et al., 1986)

Df(3R)Antp-X1

(Cavener et al., 1986)

Df(3R)BSC221

(Gresens and Cook, 2006.12.5)

Df(3R)dsx2M

(Cavener et al., 1986)

Df(3R)Exel6146

(Ryder, 2004.4.26)

Df(3R)Scx4

(Cavener et al., 1986)

In(3R)Antp^73b

(Cavener et al., 1986)

Gene not disrupted in

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^pnr-MD237

sas^GD14430

lethal | pupal stage, with Scer\GAL4^pnr-MD237

sas^GD14430

lethal | recessive

lethal - all die before end of larval stage

lethal - all die before end of larval stage | cold sensitive

lethal - all die before end of larval stage | recessive

sas¹¹

partially lethal - majority die

sas^CB03307

partially lethal - majority die, with Scer\GAL4^pnr-MD237

sas^GD14869

viable

sas^d01006

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Sterility

Allele

fertile

sas^d01006

Other Phenotypes

Allele

abnormal cell adhesion, with Scer\GAL4^fkh.PH

sas^UAS.cCa

abnormal neuroanatomy | embryonic stage 16

sas¹⁵

abnormal neuroanatomy | embryonic stage 16, with Scer\GAL4^elav.PU

sas^UAS.cLa

abnormal neuroanatomy | embryonic stage 16, with Scer\GAL4^repo.PU

sas^UAS.cLa

abnormal neuroanatomy | embryonic stage 16 (with Df(3R)ED5221)

sas¹⁵

flightless, with Scer\GAL4^Mef2.PR

some die during larval stage

some die during larval stage | cold sensitive

some die during larval stage | recessive

sas¹¹

Phenotype manifest in

Allele

embryonic/larval cuticle

embryonic/larval salivary gland, with Scer\GAL4^fkh.PH

sas^UAS.cCa

embryonic/larval tracheal section

sas^unspecified

embryonic/larval tracheal system

sas¹¹

larval anterior commissure | embryonic stage 16

sas¹⁵

larval anterior commissure | embryonic stage 16 (with Df(3R)ED5221)

sas¹⁵

larval longitudinal connective | embryonic stage 16

sas¹⁵

larval longitudinal connective | embryonic stage 16, with Scer\GAL4^elav.PU

sas^UAS.cLa

larval longitudinal connective | embryonic stage 16, with Scer\GAL4^repo.PU

sas^UAS.cLa

larval longitudinal connective | embryonic stage 16 (with Df(3R)ED5221)

sas¹⁵

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (6)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\CCN1

1 of 15

Yes

Hsap\CCN2

1 of 15

Yes

Hsap\CCN3

1 of 15

Yes

Hsap\CCN4

1 of 15

Yes

Hsap\CCN5

1 of 15

Yes

Hsap\CCN6

1 of 15

Yes

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (6)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Ccn1

1 of 15

Yes

Mmus\Ccn2

1 of 15

Yes

Mmus\Ccn3

1 of 15

Yes

Mmus\Ccn4

1 of 15

Yes

Mmus\Ccn5

1 of 15

Yes

Mmus\Ccn6

1 of 15

Yes

Rattus norvegicus (Norway rat) (6)

Rnor\Ccn1

1 of 13

Yes

Rnor\Ccn2

1 of 13

Yes

Rnor\Ccn3

1 of 13

Yes

Rnor\Ccn4

1 of 13

Yes

Rnor\Ccn5

1 of 13

Yes

Rnor\Ccn6

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (5)

Xtro\ctgf

1 of 12

Yes

Xtro\cyr61

1 of 12

Yes

Xtro\nov

1 of 12

Yes

Xtro\wisp1

1 of 12

Yes

Xtro\wisp2

1 of 12

Yes

Danio rerio (Zebrafish) (10)

Drer\ccn1

1 of 15

Yes

Drer\ccn1l1

1 of 15

Yes

Drer\ccn1l2

1 of 15

Yes

Drer\ccn2a

1 of 15

Yes

Drer\ccn2b

1 of 15

Yes

Drer\ccn4a

1 of 15

Yes

Drer\ccn4b

1 of 15

Yes

Drer\ccn5

1 of 15

Yes

Drer\ccn6

1 of 15

Yes

Drer\si:ch211-106h11.3

1 of 15

Yes

Caenorhabditis elegans (Nematode, roundworm) (0)

No records found.

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (0)

No records found.

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (1)

Gene Symbol

Score

Source

Alignment

Ccn

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

sas^d07239

ameliorates amyotrophic lateral sclerosis type 6

modeled by Hsap\FUS^{R521C.UAS.Tag:HA}

(Kankel et al., 2020)

exacerbates amyotrophic lateral sclerosis type 10

modeled by Hsap\TARDBP^{M337V.UAS.Tag:MYC}

(Kankel et al., 2020)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

sas - Ptp10D

pull down, enzyme linked immunosorbent assay, bead aggregation assay, fluorescence microscopy, inferred by author, affinity technology, tag visualisation

(Lee et al., 2013)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Lee et al., 2013)

enhanceable

(Lee et al., 2013)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Cad99C

suppressible

sas

(Chung and Andrew, 2014)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

66056

DroID - A comprehensive database of gene and protein interactions.

FBgn0002306

MIST (protein-protein) - An integrated Molecular Interaction Database

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-48

Cytogenetic map

84C8-84D1

Sequence location

3R:7,162,808..7,183,702 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

84C8-84D1

Limits computationally determined from genome sequence between P{lacW}l(3)L2100^L2100 and P{EP}EP3060^EP3060

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-48

(FlyBase, 2016)

3-44.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (14)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

19157

w¹¹¹⁸; P{XP}sas^d01006

23567

w¹¹¹⁸; Mi{ET1}sas^MB02437

85482

w¹¹¹⁸; P{XP}d07239/TM6B, Tb¹

2098

sas¹⁵ p^p cu¹/TM3, Sb¹ Ser¹

36413

y¹ w^*; Mi{MIC}sas^MI03270/TM3, Sb¹ Ser¹

65326

y¹ w^*; Mi{PT-GFSTF.1}sas^{MI03270-GFSTF.1}/TM3, Sb¹ Ser¹

2259

In(3R)Antp^73b, Antp^73b sas^Antp73b red¹ e¹/TM3, Ser¹

Kyoto

106663

sas¹⁵ p^p cu¹/TM3, Sb¹

106758

In(3R)Antp^73b, Antp^73b sas^Antp73b red¹ e¹/TM3, Sb¹

VDRC

v100901

P{KK106177}VIE-260B

v30067

w¹¹¹⁸; P{GD14430}v30067

v318129

PBac{fTRG00495.sfGFP-TVPTBF}VK00033

More stocks available...

Genomic Clones (27)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (16)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD44801

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0002306

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0002306

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

40861

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: sas CG2507

(Milshina, 1999.11)

Source for database merge of

Additional comments

Other Comments

sas has been cloned and sequenced. RNA expression during development has been determined, and the mutant phenotype analysed.

(Schonbaum et al., 1992)

sas gene function is unknown.

(Cavener et al., 1986)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 55 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40861

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q04164

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q04164

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q04164

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0002306

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0002306

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

40861/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0002306

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

sas_1
sas_2

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0002306

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0002306

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG2507

Flygut - An atlas of the Drosophila adult midgut

FBgn0002306

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

40861

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC010099

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG2507

MARRVEL_MODEL - MARRVEL (model organism gene)

40861

modMine - A data warehouse for the modENCODE project

FBgn0002306

Linkouts

BioGRID - A database of protein and genetic interactions.

66056

DroID - A comprehensive database of gene and protein interactions.

FBgn0002306

DRSC - Results frm RNAi screens

FBgn0002306

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0002306

FlyMine - An integrated database for Drosophila genomics

FBgn0002306

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

Synonyms and Secondary IDs (13)

Reported As

Symbol Synonym

CG2507

(Hosono et al., 2015, Keleman et al., 2009.8.5)

SAS

(Chung and Andrew, 2014, Ismat et al., 2013, Forster et al., 2010, Swaminathan et al., 2010, Chung et al., 2009, Andrew and Baker, 2008, Kerman et al., 2008)

l(3)84Cd

(Cavener et al., 1986, Cavener et al., 1986)

rfd

(Hajirnis and Mishra, 2021, Lim and Simmons, 1994, Schneuwly et al., 1987)

sas

(Kankel et al., 2020, Morata and Calleja, 2020, Coelho and Moreno, 2019, Fahey-Lozano et al., 2019, Ohsawa, 2019, Sarov et al., 2016, Gene Disruption Project members, 2015-, Ashwal-Fluss et al., 2014, Lee et al., 2013, Ozkan et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Davis et al., 2011, Xu et al., 2011, Swaminathan et al., 2010, Christensen et al., 2008.6.11, Buszczak et al., 2007, Gresens and Cook, 2006.12.5, Lindsley and Zimm, 1992)

Name Synonyms

Stranded at Second

(Chung and Andrew, 2014, Chung et al., 2009, Hamaratoglu et al., 2009, Andrew and Baker, 2008, Kerman et al., 2008)

Stranded at second

(Lin et al., 2015, Lee et al., 2013, Forster et al., 2010, Swaminathan et al., 2010, Lovegrove et al., 2006, Williams et al., 2004)

Stranded-at-second

(Shaye et al., 2008)

responsible for dominant phenotype

(Schneuwly et al., 1987)

stranded at Second

(Jeon and Zinn, 2009)

stranded at second

(Campbell et al., 2019, Davis et al., 2011)

stranded-at-second

(Lindsley and Zimm, 1992)

Secondary FlyBase IDs

Datasets (6)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (6)

Result

Result Type

Title

scRNAseq_2020_Cho_NI72LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 72 h after egg-laying

scRNAseq_2020_Cho_NI96LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI120LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from non-infested larvae at 120 h after egg-laying

scRNAseq_2020_Cho_WI96LG_seq_clustering

cell clustering analysis

Clustering analysis of lymph gland cells from wasp-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI96HL_seq_clustering

cell clustering analysis

Clustering analysis of circulating hemocytes from non-infested larvae at 96 h after egg-laying

scRNAseq_2020_Cho_NI120HL_seq_clustering

cell clustering analysis

Clustering analysis of circulating hemocytes from non-infested larvae at 120 h after egg-laying

References (99)

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