dbt, double-time, doubletime, CKIε, CK1ε
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.47
Gene model reviewed during 6.19
3.2 (northern blot)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\dco using the Feature Mapper tool.
Comment: reported as dorsal/lateral sensory complexes
dco transcripts are expressed in photoreceptor cells in the eye. They are also expressed in a wide region between the optic lobe and the central brain which includes the lateral neurons. They are expressed in the same pattern as per transcripts. No evidence of circadian cycling was observed for dco transcripts.
dco is expressed at similar levels in both larval and pupal stages of eye development.
dco is present in nurse cells at all stages of oogenesis with the most intense signal seen in early stages (S1-4). It is expressed in the oocyte at later stages and continues to be expressed in nurse cells. It is first expressed in follicle cells at later stages (S8,9) and is not present in all follicle cells which results in a patchy expression pattern.
GBrowse - Visual display of RNA-Seq signalsView Dmel\dco in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Sensitization to repeated cocaine exposures, a phenomenon also seen in humans and animal models and associated with enhanced drug craving, is eliminated in flies mutant for per, dco, Clk, and cyc but not tim.
dco loss of function mutants show strong effects on cell survival and growth control in imaginal discs.
The dco protein is a crucial component in the mechanism that links cell survival during proliferation to growth arrest in imaginal discs.
The gene product of the dco locus regulates per protein accumulation. The function of dco may be to reduce the stability and thus the level of accumulation of monomeric per proteins, promoting the delay between per/tim transcription and the function of the per/tim protein complex, which is essential for molecular rhythmicity.
Some of the proteins of apico-lateral junctions are required both for apico-basal cell polarity and for the signalling mechanisms controlling cell proliferation, whereas others are required more specifically in cell-cell signalling.
Mutants display hyperplastic phenotype, imaginal disc overgrowth.
Endocrine mechanisms responsible for the prolongation of larval life in dco mutants have been investigated: results suggest that delayed pupariation is caused by the overgrown imaginal discs inhibiting the production or release of ecdysteroids from the endocrine system.
Reduced ecdysteroid titer and delayed or blocked metamorphosis in mutants may be a result of altered neuropeptide production, which is probably secondary to the imaginal disc overgrowth.