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Gene Dmel\hyd

General Information
Symbol	Dmel\hyd	Species	D. melanogaster
Name	hyperplastic discs	Annotation symbol	CG9484
Feature type	protein_coding_gene	FlyBase ID	FBgn0002431
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	l(3)c43, c43
Genomic Location
Chromosome (arm)	3R	Recombination map	3-49.0
Cytogenetic map	85E5-85E5	Sequence location	3R:5,540,345..5,551,333 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene hyperplastic discs is referred to in FlyBase by the symbol Dmel\hyd (CG9484, FBgn0002431). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ubiquitin-protein ligase activity. There is experimental evidence that it is involved in the biological process: male meiosis cytokinesis; spermatid nucleus differentiation; female gonad development; imaginal disc development; eye-antennal disc morphogenesis; imaginal disc growth; spermatogenesis. 43 alleles are reported. The phenotypes of these alleles are annotated with: organ system; multicellular structure; organelle; dorsal thoracic disc; imaginal precursor; thoracic segment; anatomical structure; larval thorax; organ system subdivision; spermatocyte; elongation stage spermatid; cytoplasmic part; nucleus. It has one annotated transcript and one annotated polypeptide. Protein features are: E3 ubiquitin ligase EDD, ubiquitin-associated domain; HECT; Polyadenylate-binding protein/Hyperplastic disc protein; Regulator of chromosome condensation/beta-lactamase-inhibitor protein II; Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote; Zinc finger, N-recognin; Zinc finger, N-recognin, metazoa. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, adult Malpighian tubules, larval/adult salivary gland, larval trachea, adult ovary, adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, adult spermathecae, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1641297_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of hyd. Gene sequence location is 3R:5540345..5551333.
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	l(3)85Ea l(3)85Ea1 is a heat-sensitive allele. At 20 about half the expected number of homozygotes eclose, the remainder dying as pharate adults; those that emerge are sterile, ovaries failing to mature, testes appearing morphologically normal; they also exhibit other slight abnormalities such as extra sex-comb teeth and defective wing margins. At 22 all flies die as pharate adults with greatly reduced heads, often with duplicated antennal and palpal structures. No metamorphosis accompanies development at 25; the eye disc is virtually missing, whereas the wing and haltere discs are severely hyperplastic; disc effects autonomous in transplants. Temperature-shift experiments demonstrate a temperature-sensitive period lasting from the beginning of the second instar until the end of pupation. The 24-hr pulses of 27 during development reveal that the various phenotypic consequences of homozygosity for this allele have different TSP's. l(3)85Ea1 wing discs used to demonstrate that extra cellular proliferation is insufficient to induce transdetermination (Shearn, Martin, Davis, and Hersperger, 1984, Dev. Biol. 106: 135-46). Density of gap junctions in hyperplastic imaginal wing discs markedly reduced (Ryerse and Nagel, 1984, Dev. Biol. 105: 396-403); in shift-up experiments, reduction in gap junctions precedes the onset of tissue hyperplasia (Ryerse and Nagel, 1985, Wilhelm Roux's Arch. Dev. Biol. 194: 480-86). Cell death also observed in wing discs as early as twelve hours following application of restrictive temperature (Sedlak, 1986, Dev. Genet 6: 199-212). Mitosis normal (Gatti and Baker, 1989, Genes Dev. 3: 438-53).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Controlled Vocabulary Terms ubiquitin binding References Jia et al., 2010, J. Biol. Chem. 285(48): 37218--37226
FB2012_01	Sequence features BKN20108 HFA16971
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 85E5-85E5   Limits computationally determined from genome sequence between P{EP}CrcEP3006 and P{lacW}s2681
Experimentally Determined Cytological Location
Cytogenetic map Notes References 85E-85E   (determined by in situ hybridisation)   (Mansfield and Shearn, 1990)
Experimentally Determined Recombination Data
Location	3-49.0 (Gatti and Baker, 1989) 3-49.0 +/- 0.5 (Martin et al., 1977)
Left of (cM)	Sb red (Martin et al., 1977)
Right of (cM)	Gl (Martin et al., 1977) l(3)85Ed l(3)85Eb l(3)85Ee (Lindsley and Zimm, 1992)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\hyd for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.39
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) hyd-RA FBtr0082090  NM_079572   9073   2885
Additional Transcript Data & Comments
Reported size (kB)	9.5 (northern blot) (Mansfield et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein hyd-PA   FBpp0081568   318.9   2885   5.73     NP_524296   AAF54431
Additional Polypeptide Data & Comments
Reported size (kDa)	2897 (aa); 280 (kD observed) (Mansfield et al., 1994)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote (IPR015940) HECT (IPR000569) Polyadenylate-binding protein/Hyperplastic disc protein (IPR002004) Zinc finger, N-recognin (IPR003126) Regulator of chromosome condensation/beta-lactamase-inhibitor protein II (IPR009091) Zinc finger, N-recognin, metazoa (IPR013993) E3 ubiquitin ligase EDD, ubiquitin-associated domain (IPR024725)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202826   AA246686   AA439987   AA536249   AA698519   AE014297 AAF54431   AI387060   AI534071   AI946290   BF495015   BI171326   BI633931   BI641567   BT044480   CK133004   CK658249   CO154480   CO178937   CO184829   CO196335   CO261974   CO262281   CO264314   CO265828   CO266102   CO276758   CO280618   CO282638   CO286340   CO291304   CO299221   CO299357   CO299446   CO301165   CO301739   CO301767   CO304711   CO323807   CO325738   CO326855   CO327144   CO328139   CO332940   CO342920   EC065136   EC068244   EC073569   EC074933   EC077165   EC084354   EC085146   EC085492   EC194959   EC196065   EC196608   EC199010   EC200293   EC207965   EC210457   EC218655   EC223710   EC232947   EC252816   EC256920   EC256960   EC258608   EC258808   EC259506   EC264649   ES693243   ES695658   ES695752   ES696447   EV585970   GH783289   GH787910   GH790020   GH790205   GH794462   GH795936   GH802737   GH803483   GH810544   GH811396   GH814608   GH822155   GH843293   GH844834   GH848371   GH848875   GH849034   GH857174   GH857713   GH859938   GH882867   GH888568   GH892186   GH893680   GH893733   GH894504   GH897523   GH904335   GH918731   GH920408   GH931160   GH934200   GH935722   L14644 AAB88625
UniProtKB/Swiss-Prot	P51592
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Mansfield et al., 1994)
Additional Descriptive Data
	hyd transcripts are detected throughout development but accumulate to the highest levels in pupae. (Mansfield et al., 1994)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Mansfield et al., 1994)
Additional Descriptive Data
	Cell fractionation studies localize hyd protein to the nucleus and cytoplasm. (Mansfield et al., 1994)
Marker for
Subcellular Localization
CV Term	nucleus cytoplasm (Mansfield et al., 1994)
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0002431    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0002431 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0002431 expression level Developmental Stage   Expression Level embryo 00-02hr    3448 embryo 02-04hr    4882 embryo 04-06hr    5109 embryo 06-08hr    3943 embryo 08-10hr    3706 embryo 10-12hr    1742 embryo 12-14hr    3022 embryo 14-16hr    2250 embryo 16-18hr    2131 embryo 18-20hr    1250 embryo 20-22hr    2702 embryo 22-24hr    2720 larva L1    1664 larva L2    1394 larva L3 12hr old    1306 larva L3 puffstage 1-2    795 larva L3 puffstage 3-6    1506 larva L3 puffstage 7-9    1816 white prepupae new    1925 white prepupae 12hr    1874 white prepupae 24hr    2451 pupae 2d postWPP    1999 pupae 3d postWPP    1361 pupae 4d postWPP    828 adult male 01day    1584 adult male 05day    1706 adult male 30day    1522 adult female 01day    1682 adult female 05day    2950 adult female 30day    2877 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3448) embryo 02-04hr  (4882) embryo 04-06hr  (5109) embryo 06-08hr  (3943) embryo 08-10hr  (3706) embryo 10-12hr  (1742) embryo 12-14hr  (3022) embryo 14-16hr  (2250) embryo 16-18hr  (2131) embryo 18-20hr  (1250) embryo 20-22hr  (2702) embryo 22-24hr  (2720) larva L1  (1664) larva L2  (1394) larva L3 12hr old  (1306) larva L3 puffstage 1-2  (795) larva L3 puffstage 3-6  (1506) larva L3 puffstage 7-9  (1816) white prepupae new  (1925) white prepupae 12hr  (1874) white prepupae 24hr  (2451) pupae 2d postWPP  (1999) pupae 3d postWPP  (1361) pupae 4d postWPP  (828) adult male 01day  (1584) adult male 05day  (1706) adult male 30day  (1522) adult female 01day  (1682) adult female 05day  (2950) adult female 30day  (2877) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3448) embryo 02-04hr  (4882) embryo 04-06hr  (5109) embryo 06-08hr  (3943) embryo 08-10hr  (3706) embryo 10-12hr  (1742) embryo 12-14hr  (3022) embryo 14-16hr  (2250) embryo 16-18hr  (2131) embryo 18-20hr    1250 embryo 20-22hr  (2702) embryo 22-24hr  (2720) larva L1  (1664) larva L2    1394 larva L3 12hr old    1306 larva L3 puffstage 1-2    795 larva L3 puffstage 3-6  1506 larva L3 puffstage 7-9  (1816) white prepupae new  (1925) white prepupae 12hr  (1874) white prepupae 24hr  (2451) pupae 2d postWPP  (1999) pupae 3d postWPP    1361 pupae 4d postWPP    828 adult male 01day  (1584) adult male 05day  (1706) adult male 30day  (1522) adult female 01day  (1682) adult female 05day  (2950) adult female 30day  (2877) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3448 embryo 02-04hr    4882 embryo 04-06hr    5109 embryo 06-08hr    3943 embryo 08-10hr    3706 embryo 10-12hr    1742 embryo 12-14hr    3022 embryo 14-16hr    2250 embryo 16-18hr    2131 embryo 18-20hr    1250 embryo 20-22hr    2702 embryo 22-24hr    2720 larva L1    1664 larva L2    1394 larva L3 12hr old    1306 larva L3 puffstage 1-2    795 larva L3 puffstage 3-6    1506 larva L3 puffstage 7-9    1816 white prepupae new    1925 white prepupae 12hr    1874 white prepupae 24hr    2451 pupae 2d postWPP    1999 pupae 3d postWPP    1361 pupae 4d postWPP    828 adult male 01day    1584 adult male 05day    1706 adult male 30day    1522 adult female 01day    1682 adult female 05day    2950 adult female 30day    2877 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3448 embryo 02-04hr    4882 embryo 04-06hr    5109 embryo 06-08hr    3943 embryo 08-10hr    3706 embryo 10-12hr    1742 embryo 12-14hr    3022 embryo 14-16hr    2250 embryo 16-18hr    2131 embryo 18-20hr    1250 embryo 20-22hr    2702 embryo 22-24hr    2720 larva L1    1664 larva L2    1394 larva L3 12hr old    1306 larva L3 puffstage 1-2    795 larva L3 puffstage 3-6    1506 larva L3 puffstage 7-9    1816 white prepupae new    1925 white prepupae 12hr    1874 white prepupae 24hr    2451 pupae 2d postWPP    1999 pupae 3d postWPP    1361 pupae 4d postWPP    828 adult male 01day    1584 adult male 05day    1706 adult male 30day    1522 adult female 01day    1682 adult female 05day    2950 adult female 30day    2877 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0002431 expression level Developmental Stage   Expression Level embryo 00-02hr    3448 embryo 02-04hr    4882 embryo 04-06hr    5109 embryo 06-08hr    3943 embryo 08-10hr    3706 embryo 10-12hr    1742 embryo 12-14hr    3022 embryo 14-16hr    2250 embryo 16-18hr    2131 embryo 18-20hr    1250 embryo 20-22hr    2702 embryo 22-24hr    2720 larva L1    1664 larva L2    1394 larva L3 12hr old    1306 larva L3 puffstage 1-2    795 larva L3 puffstage 3-6    1506 larva L3 puffstage 7-9    1816 white prepupae new    1925 white prepupae 12hr    1874 white prepupae 24hr    2451 pupae 2d postWPP    1999 pupae 3d postWPP    1361 pupae 4d postWPP    828 adult male 01day    1584 adult male 05day    1706 adult male 30day    1522 adult female 01day    1682 adult female 05day    2950 adult female 30day    2877 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3448) embryo 02-04hr  (4882) embryo 04-06hr  (5109) embryo 06-08hr  (3943) embryo 08-10hr  (3706) embryo 10-12hr  (1742) embryo 12-14hr  (3022) embryo 14-16hr  (2250) embryo 16-18hr  (2131) embryo 18-20hr  (1250) embryo 20-22hr  (2702) embryo 22-24hr  (2720) larva L1  (1664) larva L2  (1394) larva L3 12hr old  (1306) larva L3 puffstage 1-2  (795) larva L3 puffstage 3-6  (1506) larva L3 puffstage 7-9  (1816) white prepupae new  (1925) white prepupae 12hr  (1874) white prepupae 24hr  (2451) pupae 2d postWPP  (1999) pupae 3d postWPP  (1361) pupae 4d postWPP  (828) adult male 01day  (1584) adult male 05day  (1706) adult male 30day  (1522) adult female 01day  (1682) adult female 05day  (2950) adult female 30day  (2877) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3448) embryo 02-04hr  (4882) embryo 04-06hr  (5109) embryo 06-08hr  (3943) embryo 08-10hr  (3706) embryo 10-12hr  1742 embryo 12-14hr  (3022) embryo 14-16hr  2250 embryo 16-18hr  2131 embryo 18-20hr    1250 embryo 20-22hr  (2702) embryo 22-24hr  (2720) larva L1  1664 larva L2    1394 larva L3 12hr old    1306 larva L3 puffstage 1-2    795 larva L3 puffstage 3-6  1506 larva L3 puffstage 7-9  1816 white prepupae new  1925 white prepupae 12hr  1874 white prepupae 24hr  2451 pupae 2d postWPP  1999 pupae 3d postWPP    1361 pupae 4d postWPP    828 adult male 01day  1584 adult male 05day  1706 adult male 30day  1522 adult female 01day  1682 adult female 05day  (2950) adult female 30day  (2877) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3448 embryo 02-04hr    4882 embryo 04-06hr    5109 embryo 06-08hr    3943 embryo 08-10hr    3706 embryo 10-12hr    1742 embryo 12-14hr    3022 embryo 14-16hr    2250 embryo 16-18hr    2131 embryo 18-20hr    1250 embryo 20-22hr    2702 embryo 22-24hr    2720 larva L1    1664 larva L2    1394 larva L3 12hr old    1306 larva L3 puffstage 1-2    795 larva L3 puffstage 3-6    1506 larva L3 puffstage 7-9    1816 white prepupae new    1925 white prepupae 12hr    1874 white prepupae 24hr    2451 pupae 2d postWPP    1999 pupae 3d postWPP    1361 pupae 4d postWPP    828 adult male 01day    1584 adult male 05day    1706 adult male 30day    1522 adult female 01day    1682 adult female 05day    2950 adult female 30day    2877 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3448 embryo 02-04hr    4882 embryo 04-06hr    5109 embryo 06-08hr    3943 embryo 08-10hr    3706 embryo 10-12hr    1742 embryo 12-14hr    3022 embryo 14-16hr    2250 embryo 16-18hr    2131 embryo 18-20hr    1250 embryo 20-22hr    2702 embryo 22-24hr    2720 larva L1    1664 larva L2    1394 larva L3 12hr old    1306 larva L3 puffstage 1-2    795 larva L3 puffstage 3-6    1506 larva L3 puffstage 7-9    1816 white prepupae new    1925 white prepupae 12hr    1874 white prepupae 24hr    2451 pupae 2d postWPP    1999 pupae 3d postWPP    1361 pupae 4d postWPP    828 adult male 01day    1584 adult male 05day    1706 adult male 30day    1522 adult female 01day    1682 adult female 05day    2950 adult female 30day    2877 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0002431    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0002431 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, adult Malpighian tubules, larval/adult salivary gland, larval trachea, adult ovary, adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, adult spermathecae, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0002431 expression level Tissue   Expression Level Larval Central Nervous System    606.925 Larval Midgut    255 Larval Hindgut    374.2 Larval Malpighian Tubules    473.4 Larval Fat Body    267.5 Larval Salivary Gland    595.6 Larval Trachea    518.125 Larval Carcass    338.85 Adult Head    341.2 Adult Eye    303.675 Adult Brain    473.5 Adult Thoracic-Abdominal Ganglion    344.4 Adult Crop    523.8 Adult Midgut    306.2 Adult Hindgut    416.3 Adult Malpighian Tubules    604.4 Adult Fat Body    487.6 Adult Salivary Gland    726 Adult Heart    434.1 Adult VirginFemale Spermatheca    260.3 Adult InseminatedFemale Spermatheca    283.5 Adult Ovary    756.2 Adult Testis    570.9 Adult Male Accessory Gland    467.5 Adult Carcass    312.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (606.925) Larval Midgut    255 Larval Hindgut    374.2 Larval Malpighian Tubules    473.4 Larval Fat Body    267.5 Larval Salivary Gland  (595.6) Larval Trachea  518.125 Larval Carcass    338.85 Adult Head    341.2 Adult Eye    303.675 Adult Brain    473.5 Adult Thoracic-Abdominal Ganglion    344.4 Adult Crop  523.8 Adult Midgut    306.2 Adult Hindgut    416.3 Adult Malpighian Tubules  (604.4) Adult Fat Body    487.6 Adult Salivary Gland  (726) Adult Heart    434.1 Adult VirginFemale Spermatheca    260.3 Adult InseminatedFemale Spermatheca    283.5 Adult Ovary  (756.2) Adult Testis  (570.9) Adult Male Accessory Gland    467.5 Adult Carcass    312.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    606.925 Larval Midgut    255 Larval Hindgut    374.2 Larval Malpighian Tubules    473.4 Larval Fat Body    267.5 Larval Salivary Gland    595.6 Larval Trachea    518.125 Larval Carcass    338.85 Adult Head    341.2 Adult Eye    303.675 Adult Brain    473.5 Adult Thoracic-Abdominal Ganglion    344.4 Adult Crop    523.8 Adult Midgut    306.2 Adult Hindgut    416.3 Adult Malpighian Tubules    604.4 Adult Fat Body    487.6 Adult Salivary Gland    726 Adult Heart    434.1 Adult VirginFemale Spermatheca    260.3 Adult InseminatedFemale Spermatheca    283.5 Adult Ovary    756.2 Adult Testis    570.9 Adult Male Accessory Gland    467.5 Adult Carcass    312.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    606.925 Larval Midgut    255 Larval Hindgut    374.2 Larval Malpighian Tubules    473.4 Larval Fat Body    267.5 Larval Salivary Gland    595.6 Larval Trachea    518.125 Larval Carcass    338.85 Adult Head    341.2 Adult Eye    303.675 Adult Brain    473.5 Adult Thoracic-Abdominal Ganglion    344.4 Adult Crop    523.8 Adult Midgut    306.2 Adult Hindgut    416.3 Adult Malpighian Tubules    604.4 Adult Fat Body    487.6 Adult Salivary Gland    726 Adult Heart    434.1 Adult VirginFemale Spermatheca    260.3 Adult InseminatedFemale Spermatheca    283.5 Adult Ovary    756.2 Adult Testis    570.9 Adult Male Accessory Gland    467.5 Adult Carcass    312.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0002431 expression level Tissue   Expression Level Larval Central Nervous System    606.925 Larval Midgut    255 Larval Hindgut    374.2 Larval Malpighian Tubules    473.4 Larval Fat Body    267.5 Larval Salivary Gland    595.6 Larval Trachea    518.125 Larval Carcass    338.85 Adult Head    341.2 Adult Eye    303.675 Adult Brain    473.5 Adult Thoracic-Abdominal Ganglion    344.4 Adult Crop    523.8 Adult Midgut    306.2 Adult Hindgut    416.3 Adult Malpighian Tubules    604.4 Adult Fat Body    487.6 Adult Salivary Gland    726 Adult Heart    434.1 Adult VirginFemale Spermatheca    260.3 Adult InseminatedFemale Spermatheca    283.5 Adult Ovary    756.2 Adult Testis    570.9 Adult Male Accessory Gland    467.5 Adult Carcass    312.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  606.925 Larval Midgut    255 Larval Hindgut    374.2 Larval Malpighian Tubules    473.4 Larval Fat Body    267.5 Larval Salivary Gland  595.6 Larval Trachea  518.125 Larval Carcass    338.85 Adult Head    341.2 Adult Eye    303.675 Adult Brain    473.5 Adult Thoracic-Abdominal Ganglion    344.4 Adult Crop  523.8 Adult Midgut    306.2 Adult Hindgut    416.3 Adult Malpighian Tubules  604.4 Adult Fat Body    487.6 Adult Salivary Gland  726 Adult Heart    434.1 Adult VirginFemale Spermatheca    260.3 Adult InseminatedFemale Spermatheca    283.5 Adult Ovary  756.2 Adult Testis  570.9 Adult Male Accessory Gland    467.5 Adult Carcass    312.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    606.925 Larval Midgut    255 Larval Hindgut    374.2 Larval Malpighian Tubules    473.4 Larval Fat Body    267.5 Larval Salivary Gland    595.6 Larval Trachea    518.125 Larval Carcass    338.85 Adult Head    341.2 Adult Eye    303.675 Adult Brain    473.5 Adult Thoracic-Abdominal Ganglion    344.4 Adult Crop    523.8 Adult Midgut    306.2 Adult Hindgut    416.3 Adult Malpighian Tubules    604.4 Adult Fat Body    487.6 Adult Salivary Gland    726 Adult Heart    434.1 Adult VirginFemale Spermatheca    260.3 Adult InseminatedFemale Spermatheca    283.5 Adult Ovary    756.2 Adult Testis    570.9 Adult Male Accessory Gland    467.5 Adult Carcass    312.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    606.925 Larval Midgut    255 Larval Hindgut    374.2 Larval Malpighian Tubules    473.4 Larval Fat Body    267.5 Larval Salivary Gland    595.6 Larval Trachea    518.125 Larval Carcass    338.85 Adult Head    341.2 Adult Eye    303.675 Adult Brain    473.5 Adult Thoracic-Abdominal Ganglion    344.4 Adult Crop    523.8 Adult Midgut    306.2 Adult Hindgut    416.3 Adult Malpighian Tubules    604.4 Adult Fat Body    487.6 Adult Salivary Gland    726 Adult Heart    434.1 Adult VirginFemale Spermatheca    260.3 Adult InseminatedFemale Spermatheca    283.5 Adult Ovary    756.2 Adult Testis    570.9 Adult Male Accessory Gland    467.5 Adult Carcass    312.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    341.2   NA  Eye    303.675   NA  Brain    473.5   606.925  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    344.4   NA  Crop    523.8   255  Midgut    306.2   374.2  Hindgut    416.3   473.4  Malpighian Tubules    604.4   267.5  Fat Body    487.6   595.6  Salivary Gland    726   NA  Heart    434.1   518.125  Trachea    NA   NA  VirginFemale Spermatheca    260.3   NA  InseminatedFemale Spermatheca    283.5   NA  Ovary    756.2   NA  Testis    570.9   NA  Male Accessory Gland    467.5   338.85  Carcass    312.7 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002431 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9484-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal hyd8 lethal | larval stage hyd14 lethal | larval stage | heat sensitive hyd36 lethal | larval stage | recessive hyd1 lethal | larval stage | recessive | heat sensitive hyd1 lethal | pharate adult stage | heat sensitive hyd1 lethal | pharate adult stage | recessive | heat sensitive hydhs1 lethal | pupal stage hyd35 lethal | pupal stage, with Scer\GAL4pnr-MD237 hydGD14227 lethal | pupal stage | heat sensitive hyd37 lethal | pupal stage | recessive hyd34 lethal | recessive hyd1 lethal | recessive | heat sensitive hyd1 semi-lethal, with Scer\GAL4pnr-MD237 hydGD14227 viable hydC017 viable (with hyd15) hydC017 viable (with hydC017) hyd15 hydhs1 viable (with hydhs1) hydC017 Sterility Allele female sterile hyd1 female sterile | recessive hyd1 male sterile hyd1 hyd37 male sterile | recessive hyd1 Other Phenotypes Allele cytokinesis defective (with hyd15) hydC017 cytokinesis defective (with hydC017) hyd15 hyperplasia | recessive hyd1 hyd37 hyperplasia | recessive | heat sensitive hydhs1 increased cell death | somatic clone hydK3.5 visible, with Scer\GAL4pnr-MD237 hydGD14227 visible | somatic clone hydK3.5 Phenotype manifest in Allele antenna | heat sensitive hyd1 centrosome (with hyd15) hydC017 centrosome (with hydC017) hyd15 egg | germline clone hyd1 elongation stage spermatid (with hyd15) hydC017 elongation stage spermatid (with hydC017) hyd15 eye | cell non-autonomous | somatic clone hydK3.5 eye-antennal disc | heat sensitive hyd1 eye disc | cell non-autonomous | somatic clone hydK3.5 haltere | heat sensitive hyd1 haltere disc hyd13 haltere disc | heat sensitive hyd1 imaginal disc hyd1 hyd34 leg | heat sensitive hyd1 meiotic primary spermatocyte (with hyd15) hydC017 meiotic primary spermatocyte (with hydC017) hyd15 mesothoracic tergum, with Scer\GAL4pnr-MD237 hydGD14227 nucleus (with hyd15) hydC017 nucleus (with hydC017) hyd15 ovary hyd1 photoreceptor cell | ectopic | somatic clone hydK3.5 photoreceptor cell | somatic clone hydK3.5 primary spermatocyte cyst (with hyd15) hydC017 primary spermatocyte cyst (with hydC017) hyd15 hydhs1 primary spermatocyte cyst (with hydhs1) hydC017 spermatogonium hydC017 spindle (with hyd15) hydC017 spindle (with hydC017) hyd15 testis hyd1 wing | heat sensitive hyd1 wing disc hyd13 wing disc | heat sensitive hyd1 wing disc | posterior compartment | somatic clone hydK7.19 wing disc | somatic clone hydK3.5
Classical Alleles ( 41 )
For All Classical Alleles Show
Allele of hyd Class Mutagen Stocks Known lesion hyd15 ethyl methanesulfonate 2 -- hydC017 1 -- hyd14 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes hyd8 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- hyd10 ethyl methanesulfonate 0 -- hyd11 ethyl methanesulfonate 0 -- hyd12 ethyl methanesulfonate 0 -- hyd13 loss of function allele ethyl methanesulfonate 0 -- hyd16 ethyl methanesulfonate 0 -- hyd17 ethyl methanesulfonate 0 -- hyd18 ethyl methanesulfonate 0 -- hyd19 ethyl methanesulfonate 0 -- hyd1 ethyl methanesulfonate 0 -- hyd20 ethyl methanesulfonate 0 -- hyd21 ethyl methanesulfonate 0 -- hyd22 X ray 0 -- hyd23 X ray 0 -- hyd24 X ray 0 -- hyd25 ethyl methanesulfonate 0 -- hyd26 ethyl methanesulfonate 0 -- hyd28 ethyl methanesulfonate 0 -- hyd29 ethyl methanesulfonate 0 -- hyd2 ethyl methanesulfonate 0 -- hyd30 ethyl methanesulfonate 0 -- hyd31 diepoxybutane 0 -- hyd32 diepoxybutane 0 -- hyd33 diepoxybutane 0 -- hyd34 PM hybrid dysgenesis 0 Yes hyd35 PM hybrid dysgenesis 0 Yes hyd36 PM hybrid dysgenesis 0 Yes hyd37 gamma ray 0 -- hyd3 ethyl methanesulfonate 0 -- hyd4 ethyl methanesulfonate 0 -- hyd5 ethyl methanesulfonate 0 -- hyd6 ethyl methanesulfonate 0 -- hyd7 ethyl methanesulfonate 0 -- hyd9 ethyl methanesulfonate 0 -- hydhs1 0 -- hydK3.5 0 -- hydK7.19 0 -- hydunspecified 0 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of hyd Class Mutagen Stocks Known lesion hydGD14227 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes hydHMS00343 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)by10 (Seshaiah et al., 2001, Mansfield et al., 1994) Df(3R)by62 (Mansfield et al., 1994) Df(3R)GB104 (Seshaiah et al., 2001, Mansfield et al., 1994) Tp(3;2)by62 (Seshaiah et al., 2001)
Not disrupted in	Df(3R)by416 (Mansfield et al., 1994)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD14227} NA P{TRiP.HMS00343} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{}hyd34 NA P{}hyd35 NA PBac{3HPy+}hydC017 NA
Gene Ontology: Function, Process & Cellular Component ( 19 unique terms )
Terms Based on Experimental Evidence ( 9 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
eye-antennal disc morphogenesis inferred from mutant phenotype (Lee et al., 2002) female gonad development inferred from mutant phenotype (Martin et al., 1977) imaginal disc development inferred from mutant phenotype (Martin et al., 1977) imaginal disc growth inferred from mutant phenotype (Mansfield et al., 1994) male meiosis cytokinesis inferred from mutant phenotype (Pertceva et al., 2010) spermatid nucleus differentiation inferred from mutant phenotype (Pertceva et al., 2010) spermatogenesis inferred from mutant phenotype (Mansfield et al., 1994, Pertceva et al., 2010)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Mansfield et al., 1994) nucleus inferred from direct assay (Mansfield et al., 1994)
Terms Based on Predictions or Assertions ( 12 terms )
Molecular Function
CV term Evidence References
RNA binding inferred from electronic annotation with InterPro:IPR002004 (FlyBase Curators et al., 2004-) ubiquitin binding inferred from electronic annotation with InterPro:IPR024725 (FlyBase Curators et al., 2004-) ubiquitin-protein ligase activity inferred from sequence or structural similarity (Amanai and Shearn, 1996) inferred from sequence or structural similarity with mouse Nedd4 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1996.10.1) zinc ion binding inferred from electronic annotation with InterPro:IPR003126 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
compound eye development non-traceable author statement (Ou et al., 2003) germ cell development non-traceable author statement (Swiss-Prot Project Members, 1996.10.1) imaginal disc development non-traceable author statement (Swiss-Prot Project Members, 1996.10.1) negative regulation of smoothened signaling pathway non-traceable author statement (Ou et al., 2003) protein modification process inferred from electronic annotation with InterPro:IPR000569 (FlyBase Curators et al., 2004-) regulation of cell proliferation non-traceable author statement (Swiss-Prot Project Members, 1996.10.1) regulation of proteolysis non-traceable author statement (Ou et al., 2003)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (Swiss-Prot Project Members, 1996.10.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions hyd allele Gene References hydK3.5 hh (Lee et al., 2002)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66340 DroID - A comprehensive database of gene and protein interactions. • FBgn0002431 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41181
Orthologs
Genome-wide drosophilid orthologs	Dana\GF11551 Dere\GG17340 Dgri\GH22338 Dmoj\GI23976 Dpse\hyd Dvir\GJ11179 Dwil\GK12903 Dyak\hyd
Curated drosophilid orthologs	Dafs\hyd (Bartolome, 2005) Dmir\hyd (Bartolome, 2005) Dpse\hyd (Bartolome, 2005) Dsim\hyd (Begun, 2000.4.5) Dyak\hyd (Begun, 2000.4.7)
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL005930-PA Aedes aegypti (mosquito) AGAP001780-PA Anopheles gambiae (mosquito) XP_392625.3 Apis mellifera (honey bee) XP_001947833.1 Acyrthosiphon pisum (pea aphid) 101562 Branchiostoma floridae (lancelet) BGIBMGA007519-PA Bombyx mori (silk worm) ENSBTAP00000028262 Bos taurus (bovine) CN23192 Caenorhabditis brenneri (small nematode) CBP26453 Caenorhabditis briggsae (nematode) CE24948 Caenorhabditis elegans (worm) ENSCAFP00000000890 Canis familiaris (dog) JA04848 Caenorhabditis japonica (nematode) CPIJ011645 Culex pipens (mosquito) RP48561 Caenorhabditis remanei (nematode) 219094 Capitella spl (polychaete worm) 49748 Daphnia pulex (daphnia) ENSDARP00000033510 Danio rerio (zebra fish) ENSECAP00000014041 Equus caballus (horse) ENSGACP00000006187 Gymnopilus aculeatus (mushroom) ENSGALP00000025803 Gallus gallus (chicken) 71154 Hypsipyla robusta (cedar shoot borer) ENSP00000220959 Homo sapiens (human) ISCW015566-PA Ixodes scapularis (deer tick) 129991 Lottia gigantea (owl limpet) ENSMODP00000007389 Monodelphis domestica (gray opossum) ENSMMUP00000027328 Macaca mulatta (rhesus monkey) ENSMUSP00000105965 Mus musculus (house mouse) 10414 Nematostella vectensis (starlet anemone) XP_001605335.1 Nasonia vitripennis (wasp) ENSOANP00000021058 Ornithorynchus anatinus (platypus) ENSORLP00000003766 Oryzias latipes (japanese killifish) PHUM001503-PA Pediculus humanus (human body louse) PP00088 Pristionchus pacificus (nematode) ENSPPYP00000021085 Pongo pygmaeus (orangutan) ENSPTRP00000035026 Pan troglodytes (chimpanzee) ENSRNOP00000009115 Rattus norvegicus (norway rat) Smp_150360 Schistosoma mansoni (trematode parasite) 58408 Trichoplax adhaerens (metazoa) XP_967079.2 Tribolium castaneum (red flour beetle) ENSTNIP00000016282 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000026187 Takifugu rubripes (pufferfish Takifugu) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15524 NV12709 LH13447 ISCW015566 FBgn0041642 FBgn0214912 FBgn0198440 FBgn0186786 FBgn0041664 JGI_V11_49748 FBgn0083515 FBgn0159544 FBgn0159542 FBgn0146700 FBgn0129796 FBgn0109567 FBgn0088591 CPIJ011645 CPIJ011644 BGIBMGA007519 ACYPI007692 GB17802 AGAP001780 AAEL005930 PHUM303880 GLEAN_14081
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	32352 y1 sc* v1; P{TRiP.HMS00343}attP2 3718 kniri-1 hyd15 e1/TM3, Sb1 16256 y1 w1118; PBac{3HPy+}hydC017/TM3, Sb1 Ser1
Kyoto	107197 kniri-1 hyd15 e1/TM3, Sb1
VDRC	v44675 w1118; P{GD14227}v44675 v44676 w1118; P{GD14227}v44676
Genomic Clones ( 2 )
	BACR23O04 BACR30F01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 77 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD13942
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT03823 GH17485 HL04850 LD03140 LD05603 LD15050 LD16741 LP15044 SD06571 SD24955 SD28135
Other clones	bs23b05 Dmel_dig_011582_0620_2782 EC28645 EK003125 EK058012 EK062527 EK077430 EK083206 EK084930 EK122005 EK138453 EK143827 EK144937 EK154501 EK160864 EK174823 EK175145 EK175454 EK180259 EK182036 EK182123 EK191535 EK197348 EK245835 EK305209 EN04219 EP04747 EP05934 EP08633 EP15739 RC0-DP0006-150700-011-A09 RE13070 RP003082521 RP003093655 RP003099170 RP003100105 RP003105733 RP003124582 RP003158421 RP003254027 RP003272504 RP003292749 RP003410792 RP003440207 RP003464972 RP003466480 RP003479551 RP003484861 RP003509717 RP003538580 RP003540605 RP003543345 RP003568522 RP003577556 RP003598628 RP003601311 RP003620857 RP003620960 RP003633220 RP003654329 RP003655417 RP003661671 RP003667253 RP003674677 RP003676315
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0002431 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41181
Antibody Information
	polyclonal (Mansfield et al., 1994)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: hyd l(3)SG33 (Shearn, 1995.5.3)
Source for database merge of
Additional comments	Also a series of P-element induced alleles recovered by Cheney.
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Cells in the eye disc that are mutant for hyd ectopically express dpp and hh in anterior regions of the disc, leading to premature photoreceptor differentiation and overgrowth of surrounding tissue. (Lee et al., 2002) Mutants display hyperplastic phenotype, with imaginal disc overgrowth. (Mechler, 1994) Endocrine mechanisms responsible for the prolongation of larval life in hyd mutants were investigated: results suggest that delayed pupariation is caused by the overgrown imaginal discs inhibiting the production or release of ecdysteroids from the endocrine system. (Sehnal and Bryant, 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079572 RefSeq (Proteins) • NP_524296 DDBJ / EMBL / GenBank • AAB88625 AAF54431 AI946290 BI171326 L14644 Entrez Gene - A searchable database of RefSeq genes. • 41181 UniProtKB/Swiss-Prot • P51592
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote (IPR015940) HECT (IPR000569) Polyadenylate-binding protein/Hyperplastic disc protein (IPR002004) Zinc finger, N-recognin (IPR003126) Regulator of chromosome condensation/beta-lactamase-inhibitor protein II (IPR009091) Zinc finger, N-recognin, metazoa (IPR013993) E3 ubiquitin ligase EDD, ubiquitin-associated domain (IPR024725)
Linkouts
	BioGRID - A database of protein and genetic interactions • 66340 DroID - A comprehensive database of gene and protein interactions. • FBgn0002431 DRSC - Results from RNAi screens. • FBgn0002431 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002431 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9484-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0002431 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41181 InParanoid A subset of ortholog calls from InParanoid. • AAEL005930-PA Aedes aegypti (mosquito) AGAP001780-PA Anopheles gambiae (mosquito) XP_392625.3 Apis mellifera (honey bee) XP_001947833.1 Acyrthosiphon pisum (pea aphid) 101562 Branchiostoma floridae (lancelet) BGIBMGA007519-PA Bombyx mori (silk worm) ENSBTAP00000028262 Bos taurus (bovine) CN23192 Caenorhabditis brenneri (small nematode) CBP26453 Caenorhabditis briggsae (nematode) CE24948 Caenorhabditis elegans (worm) ENSCAFP00000000890 Canis familiaris (dog) JA04848 Caenorhabditis japonica (nematode) CPIJ011645 Culex pipens (mosquito) RP48561 Caenorhabditis remanei (nematode) 219094 Capitella spl (polychaete worm) 49748 Daphnia pulex (daphnia) ENSDARP00000033510 Danio rerio (zebra fish) ENSECAP00000014041 Equus caballus (horse) ENSGACP00000006187 Gymnopilus aculeatus (mushroom) ENSGALP00000025803 Gallus gallus (chicken) 71154 Hypsipyla robusta (cedar shoot borer) ENSP00000220959 Homo sapiens (human) ISCW015566-PA Ixodes scapularis (deer tick) 129991 Lottia gigantea (owl limpet) ENSMODP00000007389 Monodelphis domestica (gray opossum) ENSMMUP00000027328 Macaca mulatta (rhesus monkey) ENSMUSP00000105965 Mus musculus (house mouse) 10414 Nematostella vectensis (starlet anemone) XP_001605335.1 Nasonia vitripennis (wasp) ENSOANP00000021058 Ornithorynchus anatinus (platypus) ENSORLP00000003766 Oryzias latipes (japanese killifish) PHUM001503-PA Pediculus humanus (human body louse) PP00088 Pristionchus pacificus (nematode) ENSPPYP00000021085 Pongo pygmaeus (orangutan) ENSPTRP00000035026 Pan troglodytes (chimpanzee) ENSRNOP00000009115 Rattus norvegicus (norway rat) Smp_150360 Schistosoma mansoni (trematode parasite) 58408 Trichoplax adhaerens (metazoa) XP_967079.2 Tribolium castaneum (red flour beetle) ENSTNIP00000016282 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000026187 Takifugu rubripes (pufferfish Takifugu) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /dbzhnsky/hperpdc1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41181 modMine - Data generated by the modENCODE project. • FBgn0002431 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15524 NV12709 LH13447 ISCW015566 FBgn0041642 FBgn0214912 FBgn0198440 FBgn0186786 FBgn0041664 JGI_V11_49748 FBgn0083515 FBgn0159544 FBgn0159542 FBgn0146700 FBgn0129796 FBgn0109567 FBgn0088591 CPIJ011645 CPIJ011644 BGIBMGA007519 ACYPI007692 GB17802 AGAP001780 AAEL005930 PHUM303880 GLEAN_14081
Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	c43 (Sehnal and Bryant, 1993, Szabad et al., 1991, Bryant and Schmidt, 1990) CG5119 (Pertceva et al., 2010) CG9484 (Ditzel et al., 2008, Ni et al., 2010.12.1) HYD (Lewis et al., 2004) hyd (Bartolome and Charlesworth, 2006, Grifoni et al., 2004, Robertson et al., 2000, Zhou et al., 2008, Pospisilik et al., 2010, Pertceva et al., 2010, Grusche et al., 2011) Hyd (Martin et al., 2007, Jia et al., 2010) l(3)85Ea   l(3)c43 (Mechler, 1994, Skaer, 1993, Jursnich et al., 1990, Mechler, 1990, Gateff and Mechler, 1989, ) l(3)C43 (Martin et al., 1977, ) l(3)C43-3 (Gatti and Baker, 1989) l(3)SG33   l3c43 (Ryerse and Nagel, 1984) UBE 3A (Robertson et al., 2000)
Name Synonym	hyperplastic discs (Shearn, 1993.6.9, Pertceva et al., 2010, Grusche et al., 2011)
Secondary FlyBase IDs
	FBgn0002317
References ( 76 )
Generate a list of	All references relating to this gene ( 76 )
List References by type	Research paper  ( 36 ) Supplementary material  ( 3 ) Review  ( 13 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 6 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 3 ) Protein sequence record  ( 1 ) Book  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Thesis  ( 1 )
Recent research papers ( 4 )
	Grusche et al., 2011, Dev. Biol. 350(2): 255--266 The Salvador/Warts/Hippo pathway controls regenerative tissue growth in Drosophila melanogaster. [FBrf0212888] Jia et al., 2010, J. Biol. Chem. 285(48): 37218--37226 Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus. [FBrf0214177] Pertceva et al., 2010, Cell Biol. Int. 34(10): 991--996 The role of Drosophila hyperplastic discs gene in spermatogenesis. [FBrf0211767] Pospisilik et al., 2010, Cell 140(1): 148--160 Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. [FBrf0212676] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...