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Gene Dmel\hyd

General Information
Symbol	Dmel\hyd	Species	D. melanogaster
Name	hyperplastic discs	Annotation symbol	CG9484
Feature type	protein_coding_gene	FlyBase ID	FBgn0002431
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	l(3)c43, c43
Genomic Location
Chromosome (arm)	3R	Recombination map	3-49.0
Cytogenetic map	85E5-85E5	Sequence location	3R:5,540,345..5,551,337 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene hyperplastic discs is referred to in FlyBase by the symbol Dmel\hyd (CG9484, FBgn0002431). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: ubiquitin-protein ligase activity. There is experimental evidence that it is involved in the biological process: male meiosis cytokinesis; spermatid nucleus differentiation; female gonad development; imaginal disc development; eye-antennal disc morphogenesis; imaginal disc growth; spermatogenesis. 44 alleles are reported. The phenotypes of these alleles are annotated with: organ system; multicellular structure; anatomical structure; organelle; imaginal precursor; thoracic segment; embryonic/larval imaginal precursor; intracellular organelle part; centrosome; organ system subdivision; elongation stage spermatid; nucleus. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: E3 ubiquitin ligase EDD, ubiquitin-associated domain; HECT; Polyadenylate-binding protein/Hyperplastic disc protein; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote; Zinc finger, N-recognin; Zinc finger, N-recognin, metazoa. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, adult Malpighian tubules, larval/adult salivary gland, larval trachea, adult ovary, adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, adult spermathecae, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1641297_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of hyd. Gene sequence location is 3R:5540345..5551337.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	l(3)85Ea l(3)85Ea1 is a heat-sensitive allele. At 20 about half the expected number of homozygotes eclose, the remainder dying as pharate adults; those that emerge are sterile, ovaries failing to mature, testes appearing morphologically normal; they also exhibit other slight abnormalities such as extra sex-comb teeth and defective wing margins. At 22 all flies die as pharate adults with greatly reduced heads, often with duplicated antennal and palpal structures. No metamorphosis accompanies development at 25; the eye disc is virtually missing, whereas the wing and haltere discs are severely hyperplastic; disc effects autonomous in transplants. Temperature-shift experiments demonstrate a temperature-sensitive period lasting from the beginning of the second instar until the end of pupation. The 24-hr pulses of 27 during development reveal that the various phenotypic consequences of homozygosity for this allele have different TSP's. l(3)85Ea1 wing discs used to demonstrate that extra cellular proliferation is insufficient to induce transdetermination (Shearn, Martin, Davis, and Hersperger, 1984, Dev. Biol. 106: 135-46). Density of gap junctions in hyperplastic imaginal wing discs markedly reduced (Ryerse and Nagel, 1984, Dev. Biol. 105: 396-403); in shift-up experiments, reduction in gap junctions precedes the onset of tissue hyperplasia (Ryerse and Nagel, 1985, Wilhelm Roux's Arch. Dev. Biol. 194: 480-86). Cell death also observed in wing discs as early as twelve hours following application of restrictive temperature (Sedlak, 1986, Dev. Genet 6: 199-212). Mitosis normal (Gatti and Baker, 1989, Genes Dev. 3: 438-53).
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02	Controlled Vocabulary Terms protein ubiquitination involved in ubiquitin-dependent protein catabolic process
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 85E5-85E5   Limits computationally determined from genome sequence between P{EP}CrcEP3006 and P{lacW}s2681
Experimentally Determined Cytological Location
Cytogenetic map Notes References 85E-85E   (determined by in situ hybridisation)   (Mansfield and Shearn, 1990)
Experimentally Determined Recombination Data
Location	3-49.0 (Gatti and Baker, 1989) 3-49.0 +/- 0.5 (Martin et al., 1977)
Left of (cM)	Sb red (Martin et al., 1977)
Right of (cM)	Gl (Martin et al., 1977) l(3)85Ed l(3)85Eb l(3)85Ee (Lindsley and Zimm, 1992)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\hyd for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.39 Gene model reviewed during 5.49 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) hyd-RA FBtr0082090  NM_079572   9077   2885 hyd-RB FBtr0339599     9083   2887
Additional Transcript Data & Comments
Reported size (kB)	9.5 (northern blot) (Mansfield et al., 1994)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein hyd-PA   FBpp0081568   318.9   2885   5.73     NP_524296   AAF54431 hyd-PB   FBpp0308671   319.1   2887   5.77
Additional Polypeptide Data & Comments
Reported size (kDa)	2897 (aa); 280 (kD observed) (Mansfield et al., 1994)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote (IPR015940) HECT (IPR000569) Polyadenylate-binding protein/Hyperplastic disc protein (IPR002004) Zinc finger, N-recognin (IPR003126) Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II (IPR009091) Zinc finger, N-recognin, metazoa (IPR013993) E3 ubiquitin ligase EDD, ubiquitin-associated domain (IPR024725)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202826   AA246686   AA439987   AA536249   AA698519   AE014297 AAF54431   AI387060   AI534071   AI946290   BF495015   BI171326   BI633931   BI641567   BT044480   CK133004   CK658249   CO154480   CO178937   CO184829   CO196335   CO261974   CO262281   CO264314   CO265828   CO266102   CO276758   CO280618   CO282638   CO286340   CO291304   CO299221   CO299357   CO299446   CO301165   CO301739   CO301767   CO304711   CO323807   CO325738   CO326855   CO327144   CO328139   CO332940   CO342920   EC065136   EC068244   EC073569   EC074933   EC077165   EC084354   EC085146   EC085492   EC194959   EC196065   EC196608   EC199010   EC200293   EC207965   EC210457   EC218655   EC223710   EC232947   EC252816   EC256920   EC256960   EC258608   EC258808   EC259506   EC264649   ES693243   ES695658   ES695752   ES696447   EV585970   GH783289   GH787910   GH790020   GH790205   GH794462   GH795936   GH802737   GH803483   GH810544   GH811396   GH814608   GH822155   GH843293   GH844834   GH848371   GH848875   GH849034   GH857174   GH857713   GH859938   GH882867   GH888568   GH892186   GH893680   GH893733   GH894504   GH897523   GH904335   GH918731   GH920408   GH931160   GH934200   GH935722   L14644 AAB88625
UniProtKB/Swiss-Prot	P51592
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | ubiquitous   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Mansfield et al., 1994)
Additional Descriptive Data
	hyd transcripts are detected throughout development but accumulate to the highest levels in pupae. (Mansfield et al., 1994)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Mansfield et al., 1994)
Additional Descriptive Data
	Cell fractionation studies localize hyd protein to the nucleus and cytoplasm. (Mansfield et al., 1994)
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
cytoplasm inferred from direct assay (Mansfield et al., 1994) nucleus inferred from direct assay (Mansfield et al., 1994)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, adult Malpighian tubules, larval/adult salivary gland, larval trachea, adult ovary, adult testis. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, larval/adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, adult spermathecae, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    606.925 Larval Midgut    255 Larval Hindgut    374.2 Larval Malpighian Tubules    473.4 Larval Fat Body    267.5 Larval Salivary Gland    595.6 Larval Trachea    518.125 Larval Carcass    338.85 Adult Head    341.2 Adult Eye    303.675 Adult Brain    473.5 Adult Thoracic-Abdominal Ganglion    344.4 Adult Crop    523.8 Adult Midgut    306.2 Adult Hindgut    416.3 Adult Malpighian Tubules    604.4 Adult Fat Body    487.6 Adult Salivary Gland    726 Adult Heart    434.1 Adult VirginFemale Spermatheca    260.3 Adult InseminatedFemale Spermatheca    283.5 Adult Ovary    756.2 Adult Testis    570.9 Adult Male Accessory Gland    467.5 Adult Carcass    312.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (606.925) Larval Midgut    255 Larval Hindgut    374.2 Larval Malpighian Tubules    473.4 Larval Fat Body    267.5 Larval Salivary Gland  (595.6) Larval Trachea  518.125 Larval Carcass    338.85 Adult Head    341.2 Adult Eye    303.675 Adult Brain    473.5 Adult Thoracic-Abdominal Ganglion    344.4 Adult Crop  523.8 Adult Midgut    306.2 Adult Hindgut    416.3 Adult Malpighian Tubules  (604.4) Adult Fat Body    487.6 Adult Salivary Gland  (726) Adult Heart    434.1 Adult VirginFemale Spermatheca    260.3 Adult InseminatedFemale Spermatheca    283.5 Adult Ovary  (756.2) Adult Testis  (570.9) Adult Male Accessory Gland    467.5 Adult Carcass    312.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    606.925 Larval Midgut    255 Larval Hindgut    374.2 Larval Malpighian Tubules    473.4 Larval Fat Body    267.5 Larval Salivary Gland    595.6 Larval Trachea    518.125 Larval Carcass    338.85 Adult Head    341.2 Adult Eye    303.675 Adult Brain    473.5 Adult Thoracic-Abdominal Ganglion    344.4 Adult Crop    523.8 Adult Midgut    306.2 Adult Hindgut    416.3 Adult Malpighian Tubules    604.4 Adult Fat Body    487.6 Adult Salivary Gland    726 Adult Heart    434.1 Adult VirginFemale Spermatheca    260.3 Adult InseminatedFemale Spermatheca    283.5 Adult Ovary    756.2 Adult Testis    570.9 Adult Male Accessory Gland    467.5 Adult Carcass    312.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    606.925 Larval Midgut    255 Larval Hindgut    374.2 Larval Malpighian Tubules    473.4 Larval Fat Body    267.5 Larval Salivary Gland    595.6 Larval Trachea    518.125 Larval Carcass    338.85 Adult Head    341.2 Adult Eye    303.675 Adult Brain    473.5 Adult Thoracic-Abdominal Ganglion    344.4 Adult Crop    523.8 Adult Midgut    306.2 Adult Hindgut    416.3 Adult Malpighian Tubules    604.4 Adult Fat Body    487.6 Adult Salivary Gland    726 Adult Heart    434.1 Adult VirginFemale Spermatheca    260.3 Adult InseminatedFemale Spermatheca    283.5 Adult Ovary    756.2 Adult Testis    570.9 Adult Male Accessory Gland    467.5 Adult Carcass    312.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    606.925 Larval Midgut    255 Larval Hindgut    374.2 Larval Malpighian Tubules    473.4 Larval Fat Body    267.5 Larval Salivary Gland    595.6 Larval Trachea    518.125 Larval Carcass    338.85 Adult Head    341.2 Adult Eye    303.675 Adult Brain    473.5 Adult Thoracic-Abdominal Ganglion    344.4 Adult Crop    523.8 Adult Midgut    306.2 Adult Hindgut    416.3 Adult Malpighian Tubules    604.4 Adult Fat Body    487.6 Adult Salivary Gland    726 Adult Heart    434.1 Adult VirginFemale Spermatheca    260.3 Adult InseminatedFemale Spermatheca    283.5 Adult Ovary    756.2 Adult Testis    570.9 Adult Male Accessory Gland    467.5 Adult Carcass    312.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  606.925 Larval Midgut    255 Larval Hindgut    374.2 Larval Malpighian Tubules    473.4 Larval Fat Body    267.5 Larval Salivary Gland  595.6 Larval Trachea  518.125 Larval Carcass    338.85 Adult Head    341.2 Adult Eye    303.675 Adult Brain    473.5 Adult Thoracic-Abdominal Ganglion    344.4 Adult Crop  523.8 Adult Midgut    306.2 Adult Hindgut    416.3 Adult Malpighian Tubules  604.4 Adult Fat Body    487.6 Adult Salivary Gland  726 Adult Heart    434.1 Adult VirginFemale Spermatheca    260.3 Adult InseminatedFemale Spermatheca    283.5 Adult Ovary  756.2 Adult Testis  570.9 Adult Male Accessory Gland    467.5 Adult Carcass    312.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    606.925 Larval Midgut    255 Larval Hindgut    374.2 Larval Malpighian Tubules    473.4 Larval Fat Body    267.5 Larval Salivary Gland    595.6 Larval Trachea    518.125 Larval Carcass    338.85 Adult Head    341.2 Adult Eye    303.675 Adult Brain    473.5 Adult Thoracic-Abdominal Ganglion    344.4 Adult Crop    523.8 Adult Midgut    306.2 Adult Hindgut    416.3 Adult Malpighian Tubules    604.4 Adult Fat Body    487.6 Adult Salivary Gland    726 Adult Heart    434.1 Adult VirginFemale Spermatheca    260.3 Adult InseminatedFemale Spermatheca    283.5 Adult Ovary    756.2 Adult Testis    570.9 Adult Male Accessory Gland    467.5 Adult Carcass    312.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    606.925 Larval Midgut    255 Larval Hindgut    374.2 Larval Malpighian Tubules    473.4 Larval Fat Body    267.5 Larval Salivary Gland    595.6 Larval Trachea    518.125 Larval Carcass    338.85 Adult Head    341.2 Adult Eye    303.675 Adult Brain    473.5 Adult Thoracic-Abdominal Ganglion    344.4 Adult Crop    523.8 Adult Midgut    306.2 Adult Hindgut    416.3 Adult Malpighian Tubules    604.4 Adult Fat Body    487.6 Adult Salivary Gland    726 Adult Heart    434.1 Adult VirginFemale Spermatheca    260.3 Adult InseminatedFemale Spermatheca    283.5 Adult Ovary    756.2 Adult Testis    570.9 Adult Male Accessory Gland    467.5 Adult Carcass    312.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    341.2   NA  Eye    303.675   NA  Brain    473.5   606.925  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    344.4   NA  Crop    523.8   255  Midgut    306.2   374.2  Hindgut    416.3   473.4  Malpighian Tubules    604.4   267.5  Fat Body    487.6   595.6  Salivary Gland    726   NA  Heart    434.1   518.125  Trachea    NA   NA  VirginFemale Spermatheca    260.3   NA  InseminatedFemale Spermatheca    283.5   NA  Ovary    756.2   NA  Testis    570.9   NA  Male Accessory Gland    467.5   338.85  Carcass    312.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    37 central nervous system, larvae L3    27 central nervous system, pupae P8    24 head, virgin 1-day female    13 head, virgin 4-day female    10 head, virgin 20-day female    14 head, mated 1-day female    9 head, mated 4-day female    12 head, mated 20-day female    13 head, mated 1-day male    14 head, mated 4-day male    17 head, mated 20-day male    20 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    12 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    15 fat body, pupae P8    6 carcass, larvae L3 wandering    19 carcass, 1-day adult    10 carcass, 4-day adult    12 carcass, 20-day adult    11 ovary, virgin 4-day female    59 ovary, mated 4-day female    44 testis, mated 4-day male    15 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (37) central nervous system, larvae L3  (27) central nervous system, pupae P8    24 head, virgin 1-day female    13 head, virgin 4-day female    10 head, virgin 20-day female    14 head, mated 1-day female    9 head, mated 4-day female    12 head, mated 20-day female    13 head, mated 1-day male    14 head, mated 4-day male    17 head, mated 20-day male    20 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    12 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    15 fat body, pupae P8    6 carcass, larvae L3 wandering    19 carcass, 1-day adult    10 carcass, 4-day adult    12 carcass, 20-day adult    11 ovary, virgin 4-day female  (59) ovary, mated 4-day female  (44) testis, mated 4-day male    15 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    37 central nervous system, larvae L3    27 central nervous system, pupae P8    24 head, virgin 1-day female    13 head, virgin 4-day female    10 head, virgin 20-day female    14 head, mated 1-day female    9 head, mated 4-day female    12 head, mated 20-day female    13 head, mated 1-day male    14 head, mated 4-day male    17 head, mated 20-day male    20 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    12 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    15 fat body, pupae P8    6 carcass, larvae L3 wandering    19 carcass, 1-day adult    10 carcass, 4-day adult    12 carcass, 20-day adult    11 ovary, virgin 4-day female    59 ovary, mated 4-day female    44 testis, mated 4-day male    15 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    37 central nervous system, larvae L3    27 central nervous system, pupae P8    24 head, virgin 1-day female    13 head, virgin 4-day female    10 head, virgin 20-day female    14 head, mated 1-day female    9 head, mated 4-day female    12 head, mated 20-day female    13 head, mated 1-day male    14 head, mated 4-day male    17 head, mated 20-day male    20 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    12 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    15 fat body, pupae P8    6 carcass, larvae L3 wandering    19 carcass, 1-day adult    10 carcass, 4-day adult    12 carcass, 20-day adult    11 ovary, virgin 4-day female    59 ovary, mated 4-day female    44 testis, mated 4-day male    15 accessory gland, mated 4-day male    7 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    37 central nervous system, larvae L3    27 central nervous system, pupae P8    24 head, virgin 1-day female    13 head, virgin 4-day female    10 head, virgin 20-day female    14 head, mated 1-day female    9 head, mated 4-day female    12 head, mated 20-day female    13 head, mated 1-day male    14 head, mated 4-day male    17 head, mated 20-day male    20 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    12 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    15 fat body, pupae P8    6 carcass, larvae L3 wandering    19 carcass, 1-day adult    10 carcass, 4-day adult    12 carcass, 20-day adult    11 ovary, virgin 4-day female    59 ovary, mated 4-day female    44 testis, mated 4-day male    15 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (37) central nervous system, larvae L3  27 central nervous system, pupae P8    24 head, virgin 1-day female    13 head, virgin 4-day female    10 head, virgin 20-day female    14 head, mated 1-day female    9 head, mated 4-day female    12 head, mated 20-day female    13 head, mated 1-day male    14 head, mated 4-day male    17 head, mated 20-day male    20 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    12 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    15 fat body, pupae P8    6 carcass, larvae L3 wandering    19 carcass, 1-day adult    10 carcass, 4-day adult    12 carcass, 20-day adult    11 ovary, virgin 4-day female  (59) ovary, mated 4-day female  (44) testis, mated 4-day male    15 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    37 central nervous system, larvae L3    27 central nervous system, pupae P8    24 head, virgin 1-day female    13 head, virgin 4-day female    10 head, virgin 20-day female    14 head, mated 1-day female    9 head, mated 4-day female    12 head, mated 20-day female    13 head, mated 1-day male    14 head, mated 4-day male    17 head, mated 20-day male    20 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    12 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    15 fat body, pupae P8    6 carcass, larvae L3 wandering    19 carcass, 1-day adult    10 carcass, 4-day adult    12 carcass, 20-day adult    11 ovary, virgin 4-day female    59 ovary, mated 4-day female    44 testis, mated 4-day male    15 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    37 central nervous system, larvae L3    27 central nervous system, pupae P8    24 head, virgin 1-day female    13 head, virgin 4-day female    10 head, virgin 20-day female    14 head, mated 1-day female    9 head, mated 4-day female    12 head, mated 20-day female    13 head, mated 1-day male    14 head, mated 4-day male    17 head, mated 20-day male    20 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    9 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    7 digestive system, 4-day adult    12 digestive system, 20-day adult    11 fat body, larvae L3 wandering    5 fat body, white prepupae    15 fat body, pupae P8    6 carcass, larvae L3 wandering    19 carcass, 1-day adult    10 carcass, 4-day adult    12 carcass, 20-day adult    11 ovary, virgin 4-day female    59 ovary, mated 4-day female    44 testis, mated 4-day male    15 accessory gland, mated 4-day male    7 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr    64 embryo 04-06hr    67 embryo 06-08hr    52 embryo 08-10hr    49 embryo 10-12hr    23 embryo 12-14hr    40 embryo 14-16hr    30 embryo 16-18hr    28 embryo 18-20hr    16 embryo 20-22hr    36 embryo 22-24hr    36 larva L1    22 larva L2    18 larva L3 12hr old    17 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    24 white prepupae new    25 white prepupae 12hr    25 white prepupae 24hr    32 pupae 2d postWPP    26 pupae 3d postWPP    18 pupae 4d postWPP    11 adult male 01day    21 adult male 05day    22 adult male 30day    20 adult female 01day    22 adult female 05day    39 adult female 30day    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (45) embryo 02-04hr  (64) embryo 04-06hr  (67) embryo 06-08hr  (52) embryo 08-10hr  (49) embryo 10-12hr    23 embryo 12-14hr  (40) embryo 14-16hr  (30) embryo 16-18hr  (28) embryo 18-20hr    16 embryo 20-22hr  (36) embryo 22-24hr  (36) larva L1    22 larva L2    18 larva L3 12hr old    17 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    24 white prepupae new    25 white prepupae 12hr    25 white prepupae 24hr  (32) pupae 2d postWPP  26 pupae 3d postWPP    18 pupae 4d postWPP    11 adult male 01day    21 adult male 05day    22 adult male 30day    20 adult female 01day    22 adult female 05day  (39) adult female 30day  (38) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr    64 embryo 04-06hr    67 embryo 06-08hr    52 embryo 08-10hr    49 embryo 10-12hr    23 embryo 12-14hr    40 embryo 14-16hr    30 embryo 16-18hr    28 embryo 18-20hr    16 embryo 20-22hr    36 embryo 22-24hr    36 larva L1    22 larva L2    18 larva L3 12hr old    17 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    24 white prepupae new    25 white prepupae 12hr    25 white prepupae 24hr    32 pupae 2d postWPP    26 pupae 3d postWPP    18 pupae 4d postWPP    11 adult male 01day    21 adult male 05day    22 adult male 30day    20 adult female 01day    22 adult female 05day    39 adult female 30day    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr    64 embryo 04-06hr    67 embryo 06-08hr    52 embryo 08-10hr    49 embryo 10-12hr    23 embryo 12-14hr    40 embryo 14-16hr    30 embryo 16-18hr    28 embryo 18-20hr    16 embryo 20-22hr    36 embryo 22-24hr    36 larva L1    22 larva L2    18 larva L3 12hr old    17 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    24 white prepupae new    25 white prepupae 12hr    25 white prepupae 24hr    32 pupae 2d postWPP    26 pupae 3d postWPP    18 pupae 4d postWPP    11 adult male 01day    21 adult male 05day    22 adult male 30day    20 adult female 01day    22 adult female 05day    39 adult female 30day    38 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr    64 embryo 04-06hr    67 embryo 06-08hr    52 embryo 08-10hr    49 embryo 10-12hr    23 embryo 12-14hr    40 embryo 14-16hr    30 embryo 16-18hr    28 embryo 18-20hr    16 embryo 20-22hr    36 embryo 22-24hr    36 larva L1    22 larva L2    18 larva L3 12hr old    17 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    24 white prepupae new    25 white prepupae 12hr    25 white prepupae 24hr    32 pupae 2d postWPP    26 pupae 3d postWPP    18 pupae 4d postWPP    11 adult male 01day    21 adult male 05day    22 adult male 30day    20 adult female 01day    22 adult female 05day    39 adult female 30day    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (45) embryo 02-04hr  (64) embryo 04-06hr  (67) embryo 06-08hr  (52) embryo 08-10hr  (49) embryo 10-12hr    23 embryo 12-14hr  (40) embryo 14-16hr  30 embryo 16-18hr  28 embryo 18-20hr    16 embryo 20-22hr  (36) embryo 22-24hr  (36) larva L1    22 larva L2    18 larva L3 12hr old    17 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    24 white prepupae new    25 white prepupae 12hr    25 white prepupae 24hr  32 pupae 2d postWPP  26 pupae 3d postWPP    18 pupae 4d postWPP    11 adult male 01day    21 adult male 05day    22 adult male 30day    20 adult female 01day    22 adult female 05day  (39) adult female 30day  (38) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr    64 embryo 04-06hr    67 embryo 06-08hr    52 embryo 08-10hr    49 embryo 10-12hr    23 embryo 12-14hr    40 embryo 14-16hr    30 embryo 16-18hr    28 embryo 18-20hr    16 embryo 20-22hr    36 embryo 22-24hr    36 larva L1    22 larva L2    18 larva L3 12hr old    17 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    24 white prepupae new    25 white prepupae 12hr    25 white prepupae 24hr    32 pupae 2d postWPP    26 pupae 3d postWPP    18 pupae 4d postWPP    11 adult male 01day    21 adult male 05day    22 adult male 30day    20 adult female 01day    22 adult female 05day    39 adult female 30day    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    45 embryo 02-04hr    64 embryo 04-06hr    67 embryo 06-08hr    52 embryo 08-10hr    49 embryo 10-12hr    23 embryo 12-14hr    40 embryo 14-16hr    30 embryo 16-18hr    28 embryo 18-20hr    16 embryo 20-22hr    36 embryo 22-24hr    36 larva L1    22 larva L2    18 larva L3 12hr old    17 larva L3 puffstage 1-2    10 larva L3 puffstage 3-6    20 larva L3 puffstage 7-9    24 white prepupae new    25 white prepupae 12hr    25 white prepupae 24hr    32 pupae 2d postWPP    26 pupae 3d postWPP    18 pupae 4d postWPP    11 adult male 01day    21 adult male 05day    22 adult male 30day    20 adult female 01day    22 adult female 05day    39 adult female 30day    38 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    56 Schneider line 2 Sg4    18 embryonic 1182-4H    26 embryonic GM2    45 embryonic Kc167    17 embryonic S1    29 embryonic S3    43 leg disc CME L1    20 wing disc CME-W2    38 wing disc ML-DmD8    27 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    28 wing disc ML-DmD21    4 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    32 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    31 CNS ML-DmBG2-c2    37 tumorous blood cells mbn2    31 ovary fGS/OSS    32 ovary OSC    44 ovary OSS    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (56) Schneider line 2 Sg4    18 embryonic 1182-4H  26 embryonic GM2  (45) embryonic Kc167    17 embryonic S1  (29) embryonic S3  (43) leg disc CME L1    20 wing disc CME-W2  (38) wing disc ML-DmD8  (27) wing disc ML-DmD9    21 wing disc ML-DmD16-c3  (28) wing disc ML-DmD21    4 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3  (47) eye-antennal disc ML-DmD11  (32) antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1  (31) CNS ML-DmBG2-c2  (37) tumorous blood cells mbn2  (31) ovary fGS/OSS  (32) ovary OSC  (44) ovary OSS    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    56 Schneider line 2 Sg4    18 embryonic 1182-4H    26 embryonic GM2    45 embryonic Kc167    17 embryonic S1    29 embryonic S3    43 leg disc CME L1    20 wing disc CME-W2    38 wing disc ML-DmD8    27 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    28 wing disc ML-DmD21    4 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    32 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    31 CNS ML-DmBG2-c2    37 tumorous blood cells mbn2    31 ovary fGS/OSS    32 ovary OSC    44 ovary OSS    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    56 Schneider line 2 Sg4    18 embryonic 1182-4H    26 embryonic GM2    45 embryonic Kc167    17 embryonic S1    29 embryonic S3    43 leg disc CME L1    20 wing disc CME-W2    38 wing disc ML-DmD8    27 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    28 wing disc ML-DmD21    4 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    32 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    31 CNS ML-DmBG2-c2    37 tumorous blood cells mbn2    31 ovary fGS/OSS    32 ovary OSC    44 ovary OSS    24 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    56 Schneider line 2 Sg4    18 embryonic 1182-4H    26 embryonic GM2    45 embryonic Kc167    17 embryonic S1    29 embryonic S3    43 leg disc CME L1    20 wing disc CME-W2    38 wing disc ML-DmD8    27 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    28 wing disc ML-DmD21    4 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    32 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    31 CNS ML-DmBG2-c2    37 tumorous blood cells mbn2    31 ovary fGS/OSS    32 ovary OSC    44 ovary OSS    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (56) Schneider line 2 Sg4    18 embryonic 1182-4H  26 embryonic GM2  (45) embryonic Kc167    17 embryonic S1  29 embryonic S3  (43) leg disc CME L1    20 wing disc CME-W2  (38) wing disc ML-DmD8  27 wing disc ML-DmD9    21 wing disc ML-DmD16-c3  28 wing disc ML-DmD21    4 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3  (47) eye-antennal disc ML-DmD11  32 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1  31 CNS ML-DmBG2-c2  (37) tumorous blood cells mbn2  31 ovary fGS/OSS  32 ovary OSC  (44) ovary OSS    24 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    56 Schneider line 2 Sg4    18 embryonic 1182-4H    26 embryonic GM2    45 embryonic Kc167    17 embryonic S1    29 embryonic S3    43 leg disc CME L1    20 wing disc CME-W2    38 wing disc ML-DmD8    27 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    28 wing disc ML-DmD21    4 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    32 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    31 CNS ML-DmBG2-c2    37 tumorous blood cells mbn2    31 ovary fGS/OSS    32 ovary OSC    44 ovary OSS    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    56 Schneider line 2 Sg4    18 embryonic 1182-4H    26 embryonic GM2    45 embryonic Kc167    17 embryonic S1    29 embryonic S3    43 leg disc CME L1    20 wing disc CME-W2    38 wing disc ML-DmD8    27 wing disc ML-DmD9    21 wing disc ML-DmD16-c3    28 wing disc ML-DmD21    4 wing disc ML-DmD32    18 haltere disc ML-DmD17-c3    47 eye-antennal disc ML-DmD11    32 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    16 CNS ML-DmBG1-c1    31 CNS ML-DmBG2-c2    37 tumorous blood cells mbn2    31 ovary fGS/OSS    32 ovary OSC    44 ovary OSS    24 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    7 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    36 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    39 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    7 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult  (36) Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3  (39) Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (29) Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult  (27) Paraquat 10 mM 48 hrs, 4-day adult  (29) Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    7 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    36 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    39 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    7 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    36 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    39 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    7 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    36 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    39 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    7 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult  (36) Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3  (39) Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  29 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult  27 Paraquat 10 mM 48 hrs, 4-day adult  29 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    7 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    36 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    39 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    10 cold shock, 4-day adult    7 heat shock, 4-day adult    21 Cadmium 50 mM 6 hrs, larvae L3    6 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    18 Cadmium 100 mM 48 hrs, 4-day adult    36 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    4 Zinc 4.5 mM 48 hrs, 4-day adult    14 Ethanol 2.5% 3 hrs, larvae L3    39 Ethanol 5% 3 hrs, larvae L3    9 Ethanol 10% 3 hrs, larvae L3    7 Caffeine 1.5 mg/ml 4 hrs, larvae L3    10 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    29 Caffeine 25 mg/ml 48 hrs, 4-day adult    10 Paraquat 5 mM 48 hrs, 4-day adult    27 Paraquat 10 mM 48 hrs, 4-day adult    29 Rotenone 2 μg 12 hrs, larvae L3    7 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • RE13070 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002431 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9484-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal hyd8 lethal | larval stage hyd14 lethal | larval stage | heat sensitive hyd36 lethal | larval stage | recessive hyd1 lethal | larval stage | recessive | heat sensitive hyd1 lethal | pharate adult stage | heat sensitive hyd1 lethal | pharate adult stage | recessive | heat sensitive hydhs1 lethal | pupal stage hyd35 lethal | pupal stage, with Scer\GAL4pnr-MD237 hydGD14227 lethal | pupal stage | heat sensitive hyd37 lethal | pupal stage | recessive hyd34 lethal | recessive hyd1 lethal | recessive | heat sensitive hyd1 partially lethal - majority die, with Scer\GAL4pnr-MD237 hydGD14227 viable hydC017 viable (with hyd15) hydC017 viable (with hydC017) hyd15 hydhs1 viable (with hydhs1) hydC017 Sterility Allele female sterile hyd1 female sterile | recessive hyd1 male sterile hyd1 hyd37 male sterile | recessive hyd1 Other Phenotypes Allele cytokinesis defective (with hyd15) hydC017 cytokinesis defective (with hydC017) hyd15 hyperplasia | recessive hyd1 hyd37 hyperplasia | recessive | heat sensitive hydhs1 increased cell death | somatic clone hydK3.5 visible, with Scer\GAL4pnr-MD237 hydGD14227 visible | somatic clone hydK3.5 Phenotype manifest in Allele antenna | heat sensitive hyd1 centrosome (with hyd15) hydC017 centrosome (with hydC017) hyd15 egg | germline clone hyd1 elongation stage spermatid (with hyd15) hydC017 elongation stage spermatid (with hydC017) hyd15 eye | cell non-autonomous | somatic clone hydK3.5 eye-antennal disc | heat sensitive hyd1 eye disc | cell non-autonomous | somatic clone hydK3.5 haltere | heat sensitive hyd1 haltere disc hyd13 haltere disc | heat sensitive hyd1 imaginal disc hyd1 hyd34 leg | heat sensitive hyd1 meiotic primary spermatocyte (with hyd15) hydC017 meiotic primary spermatocyte (with hydC017) hyd15 mesothoracic tergum, with Scer\GAL4pnr-MD237 hydGD14227 nucleus (with hyd15) hydC017 nucleus (with hydC017) hyd15 ovary hyd1 photoreceptor cell | ectopic | somatic clone hydK3.5 photoreceptor cell | somatic clone hydK3.5 primary spermatocyte cyst (with hyd15) hydC017 primary spermatocyte cyst (with hydC017) hyd15 hydhs1 primary spermatocyte cyst (with hydhs1) hydC017 spermatogonium hydC017 spindle (with hyd15) hydC017 spindle (with hydC017) hyd15 testis hyd1 wing | heat sensitive hyd1 wing disc hyd13 wing disc | heat sensitive hyd1 wing disc | posterior compartment | somatic clone hydK7.19 wing disc | somatic clone hydK3.5
Classical Alleles ( 41 )
For All Classical Alleles Show
Allele of hyd Class Mutagen Stocks Known lesion hyd15 ethyl methanesulfonate 2 -- hydC017 1 -- hyd14 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes hyd8 amorphic allele - genetic evidence ethyl methanesulfonate 0 -- hyd10 ethyl methanesulfonate 0 -- hyd11 ethyl methanesulfonate 0 -- hyd12 ethyl methanesulfonate 0 -- hyd13 loss of function allele ethyl methanesulfonate 0 -- hyd16 ethyl methanesulfonate 0 -- hyd17 ethyl methanesulfonate 0 -- hyd18 ethyl methanesulfonate 0 -- hyd19 ethyl methanesulfonate 0 -- hyd1 ethyl methanesulfonate 0 -- hyd20 ethyl methanesulfonate 0 -- hyd21 ethyl methanesulfonate 0 -- hyd22 X ray 0 -- hyd23 X ray 0 -- hyd24 X ray 0 -- hyd25 ethyl methanesulfonate 0 -- hyd26 ethyl methanesulfonate 0 -- hyd28 ethyl methanesulfonate 0 -- hyd29 ethyl methanesulfonate 0 -- hyd2 ethyl methanesulfonate 0 -- hyd30 ethyl methanesulfonate 0 -- hyd31 diepoxybutane 0 -- hyd32 diepoxybutane 0 -- hyd33 diepoxybutane 0 -- hyd34 PM hybrid dysgenesis 0 Yes hyd35 PM hybrid dysgenesis 0 Yes hyd36 PM hybrid dysgenesis 0 Yes hyd37 gamma ray 0 -- hyd3 ethyl methanesulfonate 0 -- hyd4 ethyl methanesulfonate 0 -- hyd5 ethyl methanesulfonate 0 -- hyd6 ethyl methanesulfonate 0 -- hyd7 ethyl methanesulfonate 0 -- hyd9 ethyl methanesulfonate 0 -- hydhs1 0 -- hydK3.5 0 -- hydK7.19 0 -- hydunspecified 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of hyd Class Mutagen Stocks Known lesion hydGD14227 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes hydHMS00343 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes hydNIG.9484R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)by10 (Seshaiah et al., 2001, Mansfield et al., 1994) Df(3R)by62 (Mansfield et al., 1994) Df(3R)GB104 (Seshaiah et al., 2001, Mansfield et al., 1994) Tp(3;2)by62 (Seshaiah et al., 2001)
Not disrupted in	Df(3R)by416 (Mansfield et al., 1994)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD14227} NA P{NIG.9484R} NA P{TRiP.HMS00343} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{}hyd34 NA P{}hyd35 NA PBac{3HPy+}hydC017 NA
Gene Ontology: Function, Process & Cellular Component ( 19 unique terms )
Terms Based on Experimental Evidence ( 9 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
eye-antennal disc morphogenesis inferred from mutant phenotype (Lee et al., 2002) female gonad development inferred from mutant phenotype (Martin et al., 1977) imaginal disc development inferred from mutant phenotype (Martin et al., 1977) imaginal disc growth inferred from mutant phenotype (Mansfield et al., 1994) male meiosis cytokinesis inferred from mutant phenotype (Pertceva et al., 2010) spermatid nucleus differentiation inferred from mutant phenotype (Pertceva et al., 2010) spermatogenesis inferred from mutant phenotype (Mansfield et al., 1994, Pertceva et al., 2010)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Mansfield et al., 1994) nucleus inferred from direct assay (Mansfield et al., 1994)
Terms Based on Predictions or Assertions ( 12 terms )
Molecular Function
CV term Evidence References
RNA binding inferred from electronic annotation with InterPro:IPR002004 (FlyBase Curators et al., 2004-) ubiquitin binding inferred from electronic annotation with InterPro:IPR024725 (FlyBase Curators et al., 2004-) ubiquitin-protein ligase activity inferred from biological aspect of ancestor with PANTHER:PTN000134256 (assigned by RefGenome) (Gaudet et al., 2010) inferred from sequence or structural similarity (Amanai and Shearn, 1996) inferred from sequence or structural similarity with mouse Nedd4 (FlyBase, 1992-) non-traceable author statement (Swiss-Prot Project Members, 1996.10.1) zinc ion binding inferred from electronic annotation with InterPro:IPR003126 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
compound eye development non-traceable author statement (Ou et al., 2003) germ cell development non-traceable author statement (Swiss-Prot Project Members, 1996.10.1) imaginal disc development non-traceable author statement (Swiss-Prot Project Members, 1996.10.1) negative regulation of smoothened signaling pathway non-traceable author statement (Ou et al., 2003) protein ubiquitination involved in ubiquitin-dependent protein catabolic process inferred from biological aspect of ancestor with PANTHER:PTN000134256 (assigned by RefGenome) (Gaudet et al., 2010) regulation of cell proliferation non-traceable author statement (Swiss-Prot Project Members, 1996.10.1) regulation of proteolysis non-traceable author statement (Ou et al., 2003)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (Swiss-Prot Project Members, 1996.10.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
hyd - Arp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - Arr2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - Art2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - Brf anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - CG10496 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - CG11190 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - CG11652 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - CG12123 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - CG14262 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - CG14695 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - CG14826 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - CG1561 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - CG15800 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - CG30195 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - CG30350 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - CG30412 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - CG30496 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - CG31835 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - CG32295 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - CG32698 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - CG33523 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - CG3358 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - CG3526 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - CG4004 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - CG4164 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - CG4901 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - CG5027 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - CG5190 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - CG5541 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - CG5961 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - CG6034 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - CG7053 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - CG7609 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - CG8368 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - CG9062 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - CG9547 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - CG9596 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - CR18854 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - CanA1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - CkIIβ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - Corp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - Gad1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - Gmd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - Gs1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - Hph anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - Hsp22 experimental knowledge based (Guruharsha et al., 2011) hyd - Hsp70Aa experimental knowledge based (Guruharsha et al., 2011) hyd - Jon44E anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - Mkp3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - Nle anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - O-fut2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - Pdk1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - Pk17E anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - Pp2B-14D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - Prosβ2R2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - Rad9 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - RagC-D anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - RasGAP1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - Rpb4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - Rpt1 experimental knowledge based (Guruharsha et al., 2011) hyd - Rpt6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - Ssl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - Trf anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - Uvrag anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - Vha36-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - Vhl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - atms anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - dimm anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - fd59A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - flw anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - fzr2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - kay anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - lectin-46Ca anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - mib2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - mts anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - puc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - thoc7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) hyd - wee anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions hyd allele Gene References hydK3.5 hh (Lee et al., 2002)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 66340 DroID - A comprehensive database of gene and protein interactions. • FBgn0002431 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41181 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P51592
Orthologs
OrthoDB Orthologs (40) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6G4H8P Dipteran inclusive ortholog search EOG6R242Q, EOG61G3CH Insect inclusive ortholog search EOG61ZD5N Arthropod inclusive ortholog search EOG6JM64F Metazoa inclusive ortholog search EOG6S260S
Orthologs in Drosophila Species (EOG6G4H8P)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\hyd     Drosophila simulans   Dsim\hyd     Drosophila erecta   Dere\GG17340 Y   Drosophila yakuba   Dyak\hyd Y   Drosophila ananassae   Dana\GF11551 Y   Drosophila pseudoobscura pseudoobscura   Dpse\hyd Y   Drosophila persimilis   Dper\GL21951     Drosophila persimilis   Dper\GL21949     Drosophila willistoni   Dwil\GK12903 Y   Drosophila virilis   Dvir\GJ11179 Y   Drosophila mojavensis   Dmoj\GI23976 Y   Drosophila grimshawi   Dgri\GH22338 Y
Orthologs in non-Drosophila Dipterans (EOG6R242Q, EOG61G3CH)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL005930   Anopheles gambiae Malaria mosquito  Agam\AGAP001780   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ011645
Orthologs in non-Dipteran Insects (EOG61ZD5N)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB45281   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG005902   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH10525   Atta cephalotes Leafcutter ant  Acep\ACEP23276   Camponotus floridanus Florida carpenter ant  Cflo\CFLO12666   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL15675   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL27023   Linepithema humile Argentine ant  Lhum\LH13447   Pogonomyrmex barbatus Red harvester ant  Pbar\PB15524   Acyrthosiphon pisum Pea aphid  Apim\ACYPI007692   Bombyx mori Silkmoth  Bmor\BGIBMGA007519   Pediculus humanus Human body louse  Phum\PHUM303880   Tribolium castaneum Red flour beetle  Tcas\TC014081
Orthologs in non-Insect Arthropods (EOG6JM64F)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\HYD   Daphnia pulex Water flea  Dpux\JGI_V11_98546   Ixodes scapularis Deer tick  Isca\ISCW015566
Orthologs in non-Arthropod Metazoa (EOG6S260S)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\F36A2.13   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_011574gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_008256gn   Danio rerio Zebrafish  Drer\ubr5   Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000031995   Gallus gallus Domestic chicken  Ggal\LOC771634   Mus musculus House mouse  Mmus\Ubr5   Rattus norvegicus Norway rat  Rnor\Ubr5   Homo sapiens Human  Hsap\UBR5
Human Orthologs (1)
Gene OMIM HGNC Hsap\UBR5
AAA Orthologs (8) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila erecta Dere\GG17340 Drosophila yakuba Dyak\hyd Drosophila ananassae Dana\GF11551 Drosophila pseudoobscura pseudoobscura Dpse\hyd Drosophila willistoni Dwil\GK12903 Drosophila virilis Dvir\GJ11179 Drosophila mojavensis Dmoj\GI23976 Drosophila grimshawi Dgri\GH22338
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	32352 y1 sc* v1; P{TRiP.HMS00343}attP2 3718 kniri-1 hyd15 e1/TM3, Sb1 16256 y1 w1118; PBac{3HPy+}hydC017/TM3, Sb1 Ser1
Kyoto	107197 kniri-1 hyd15 e1/TM3, Sb1
VDRC	v44675 w1118; P{GD14227}v44675 v44676 w1118; P{GD14227}v44676
Genomic Clones ( 2 )
	BACR23O04 BACR30F01 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 77 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD13942
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT03823 GH17485 HL04850 LD03140 LD05603 LD15050 LD16741 LP15044 SD06571 SD24955 SD28135
Other clones	bs23b05 Dmel_dig_011582_0620_2782 EC28645 EK003125 EK058012 EK062527 EK077430 EK083206 EK084930 EK122005 EK138453 EK143827 EK144937 EK154501 EK160864 EK174823 EK175145 EK175454 EK180259 EK182036 EK182123 EK191535 EK197348 EK245835 EK305209 EN04219 EP04747 EP05934 EP08633 EP15739 RC0-DP0006-150700-011-A09 RE13070 RP003082521 RP003093655 RP003099170 RP003100105 RP003105733 RP003124582 RP003158421 RP003254027 RP003272504 RP003292749 RP003410792 RP003440207 RP003464972 RP003466480 RP003479551 RP003484861 RP003509717 RP003538580 RP003540605 RP003543345 RP003568522 RP003577556 RP003598628 RP003601311 RP003620857 RP003620960 RP003633220 RP003654329 RP003655417 RP003661671 RP003667253 RP003674677 RP003676315
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0002431 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41181
Antibody Information
	polyclonal (Mansfield et al., 1994)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: hyd l(3)SG33 (Shearn, 1995.5.3)
Source for database merge of
Additional comments	Also a series of P-element induced alleles recovered by Cheney.
Other Comments
	dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Cells in the eye disc that are mutant for hyd ectopically express dpp and hh in anterior regions of the disc, leading to premature photoreceptor differentiation and overgrowth of surrounding tissue. (Lee et al., 2002) Mutants display hyperplastic phenotype, with imaginal disc overgrowth. (Mechler, 1994) Endocrine mechanisms responsible for the prolongation of larval life in hyd mutants were investigated: results suggest that delayed pupariation is caused by the overgrown imaginal discs inhibiting the production or release of ecdysteroids from the endocrine system. (Sehnal and Bryant, 1993)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079572 RefSeq (Proteins) • NP_524296 DDBJ / EMBL / GenBank • AAB88625 AAF54431 AI946290 BI171326 L14644 Entrez Gene - A searchable database of RefSeq genes. • 41181 UniProtKB/Swiss-Prot • P51592
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote (IPR015940) HECT (IPR000569) Polyadenylate-binding protein/Hyperplastic disc protein (IPR002004) Zinc finger, N-recognin (IPR003126) Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II (IPR009091) Zinc finger, N-recognin, metazoa (IPR013993) E3 ubiquitin ligase EDD, ubiquitin-associated domain (IPR024725) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE13070
Linkouts
	BioGRID - A database of protein and genetic interactions • 66340 DroID - A comprehensive database of gene and protein interactions. • FBgn0002431 DRSC - Results from RNAi screens. • FBgn0002431 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0002431 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9484-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0002431 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 41181 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /dbzhnsky/hperpdc1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 41181 modMine - Data generated by the modENCODE project. • FBgn0002431 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • P51592
Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	c43 (Sehnal and Bryant, 1993, Szabad et al., 1991, Bryant and Schmidt, 1990) CG5119 (Pertceva et al., 2010) CG9484 (Ditzel et al., 2008, Ni et al., 2010.12.1) HYD (Lewis et al., 2004) hyd (Bartolome and Charlesworth, 2006, Grifoni et al., 2004, Robertson et al., 2000, Zhou et al., 2008, Pospisilik et al., 2010, Pertceva et al., 2010, Grusche et al., 2011, Davis et al., 2011, Japanese National Institute of Genetics, 2012.5.21, Justiniano et al., 2012) Hyd (Omelyanchuk et al., 2009, Martin et al., 2007, Jia et al., 2010) l(3)85Ea   l(3)c43 (Mechler, 1994, Skaer, 1993, Jursnich et al., 1990, Mechler, 1990, Gateff and Mechler, 1989, ) l(3)C43 (Martin et al., 1977, ) l(3)C43-3 (Gatti and Baker, 1989) l(3)SG33   l3c43 (Ryerse and Nagel, 1984) UBE 3A (Robertson et al., 2000)
Name Synonym	hyperplastic discs (Shearn, 1993.6.9, Pertceva et al., 2010, Grusche et al., 2011, Davis et al., 2011, Justiniano et al., 2012)
Secondary FlyBase IDs
	FBgn0002317
References ( 87 )
Generate a list of	All references relating to this gene ( 87 )
List References by type	Research paper  ( 41 ) Supplementary material  ( 5 ) Review  ( 13 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 6 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 3 ) Stock list  ( 1 ) Protein sequence record  ( 1 ) Website  ( 2 ) Book  ( 1 ) Curated genome annotation  ( 1 ) Thesis  ( 1 )
Recent research papers ( 5 )
	Adamson and Lajeunesse, 2012, ScientificWorldJournal 2012: 347597 A Study of Epstein-Barr Virus BRLF1 Activity in a Drosophila Model System. [FBrf0218446] Justiniano et al., 2012, PLoS ONE 7(2): e31417 Loss of the Tumor Suppressor Pten Promotes Proliferation of Drosophila melanogaster Cells In Vitro and Gives Rise to Continuous Cell Lines. [FBrf0217611] Weber et al., 2012, PLoS ONE 7(4): e34745 Genome-Wide Association Analysis of Oxidative Stress Resistance in Drosophila melanogaster. [FBrf0218073] Davis et al., 2011, BMC Dev. Biol. 11: 66 Identification of common and cell type specific LXXLL motif EcR cofactors using a bioinformatics refined candidate RNAi screen in Drosophila melanogaster cell lines. [FBrf0216830] Grusche et al., 2011, Dev. Biol. 350(2): 255--266 The Salvador/Warts/Hippo pathway controls regenerative tissue growth in Drosophila melanogaster. [FBrf0212888] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...